48 studies found for:    sickle cell anemia OR sickle cell disease OR hemoglobin S disease OR hemoglobin SS disease | Open Studies | NIH, U.S. Fed
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Rank Status Study
1 Recruiting Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Conditions: Sickle Cell Disease;   Thalassemia;   Stem Cell Transplantation;   Graft vs Host Disease
Interventions: Drug: Alemtuzumab;   Drug: Sirolimus;   Drug: Cyclophosphamide;   Drug: Pentostatin;   Drug: Radiotherapy
2 Recruiting Blood Flow and Pain Crises in People With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
3 Recruiting Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
Conditions: Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:
4 Recruiting Genetics and Pain Severity in Sickle Cell Disease
Conditions: Genotype;   Pain;   Sickle Cell Anemia;   Vaso-Occlusive Pain Crisis
Intervention:
5 Recruiting Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease
Conditions: Sickle Cell Disease;   Sickle Cell Trait
Intervention:
6 Recruiting Natural History of Sickle Cell Disease and Other Hemolytic Disorders
Conditions: Hemoglobin SC Disease;   Hematologic Diseases;   Sickle Cell Anemia;   Hemolytic Anemia
Intervention:
7 Recruiting Comparing Acute Pain Management Protocols for Patients With Sickle Cell Disease
Condition: Sickle Cell Disease
Interventions: Drug: Hydromorphone (Standardized, weight-based dosing);   Drug: Morphine Sulfate (Standardized, weight-based dosing);   Drug: Hydromorphone (Patient Specific dosing);   Drug: Morphine Sulfate (Patient Specific dosing)
8 Recruiting Assessment of Algorithm-Based Hydroxyurea Dosing on Fetal Hemoglobin Response, Acute Complications, and Organ Function in People With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: Hydroxyurea
9 Unknown  The Link Between Anemia and Deficits in Memory and Attention in Individuals With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention:
10 Recruiting Insights Into Microbiome and Environmental Contributions to Sickle Cell Disease and Leg Ulcers Study (INSIGHTS Study)
Conditions: Genetic Disease;   Genomics
Intervention:
11 Recruiting Evaluation of Sickle Cell Liver Disease
Condition: Sickle Cell Disease
Intervention:
12 Recruiting Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
Conditions: Congenital Hemolytic Anemia;   Diamond-Blackfan Anemia
Interventions: Procedure: Radiotherapy;   Drug: Alemtuzumab (Campath );   Drug: Sirolimus (Rapamune )
13 Recruiting Screening for Subjects to Participate in Studies of Blood Disorders
Conditions: Bone Marrow Transplant;   Sickle Cell Disease;   G-CSF
Intervention:
14 Recruiting MBSR for Pain Catastrophizing in SCD
Condition: Anemia, Sickle Cell
Intervention: Behavioral: Mindfulness-based Stress Reduction
15 Recruiting Longitudinal Changes in Exercise Capacity in Children and Young Adults With Sickle Cell Anemia
Condition: Sickle Cell Anemia
Intervention:
16 Recruiting Enhancing Use of Hydroxyurea In Sickle Cell Disease Using Patient Navigators
Condition: Sickle Cell Disease
Interventions: Behavioral: Patient Navigator;   Behavioral: HU Offer and Dosing to MTD
17 Recruiting Hydroxyurea to Prevent Brain Injury in Sickle Cell Disease
Conditions: Sickle Cell Disease;   Stroke
Interventions: Drug: Hydroxyurea;   Drug: Placebo
18 Recruiting Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed By Donor Bone Marrow Transplant in Treating Patients With Sickle Cell Anemia and Other Blood Disorders
Condition: Sickle Cell Disease
Interventions: Drug: cyclophosphamide;   Drug: fludarabine phosphate;   Drug: mycophenolate mofetil;   Drug: Sirolimus;   Procedure: Allogeneic bone marrow transplantation;   Radiation: total-body irradiation;   Drug: Levetiracetam
19 Recruiting A New Reagent Assay Examining Natural Parvovirus B19 Infection in Sickle Cell Disease
Condition: Sickle Cell Disease
Interventions: Other: Blood draw;   Other: Nasopharyngeal wash
20 Recruiting A Phase II Trial of Regadenoson in Sickle Cell Anemia
Condition: Sickle Cell Anemia
Interventions: Drug: Regadenoson;   Drug: Placebo

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