| 1 |
NCT01899339 |
Unknown † |
Long Term Study Looking at the Effects of Treating Submassive Pulmonary Embolism With Ultra-sound Accelerated Thrombolysis |
- Treatment of Submassive Pulmonary Embolism
|
- Other: Ultra sound energy along with tPA to treat submassive pulmonary embolism
|
Observational
|
|
- Spectrum Health Hospitals
- EKOS Corporation
- Advanced Radiology Services
|
Other / Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Change in Right Ventricular:Left Ventricular ratio
- recurrent pulmonary embolism
|
25 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01899339 |
2013-069
Ekos |
SPEAR |
May 2013 |
May 2014 |
May 2014 |
July 15, 2013 |
July 15, 2013 |
|
- Spectrum Health Hospitals
Grand Rapids, Michigan, United States
|
|
| 2 |
NCT02709174 |
Completed |
Pulmonary Embolism in Pregnancy: Biomarkers and Clinical Predictive Models |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Serum D-dimer levels (ug/ml)
- Modified Well's Criteria- a risk scoring system for likelihood of pulmonary embolism
|
59 |
Female |
18 Years to 50 Years (Adult) |
NCT02709174 |
IRB 5699 |
|
February 2014 |
August 2015 |
August 2015 |
March 15, 2016 |
March 15, 2016 |
|
|
|
| 3 |
NCT03525535 |
Recruiting |
Prevalence Rate of Pulmonary Embolism Among Not Anticoagulated Patients |
|
|
Observational
|
|
- Centre Hospitalier Intercommunal de Toulon La Seyne sur Mer
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Pulmonary embolism prevalence
- Assess the impact of the Prandoni's recommendations on the paraclinical evaluations
|
110 |
All |
75 Years and older (Older Adult) |
NCT03525535 |
2017-CHITS-04
2017-A01197-46 |
MAXIME |
June 14, 2018 |
June 14, 2020 |
December 2020 |
May 15, 2018 |
July 17, 2018 |
|
- Centre Hospitalier Intercommunal Toulon La Seyne sur Mer
La Seyne-sur-Mer, Var, France
|
|
| 4 |
NCT02890706 |
Completed |
Iodine Mapping Using Subtraction in Pulmonary Embolism CT Versus Dual-Energy CT |
|
- Device: Iodine Mapping using Subtraction in Pulmonary Embolism Computed Tomography versus Dual Energy Computed Tomography
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Presence of perfusion defects as reference standard
- Radiation dose
- Clinical diagnosis of Pulmonary embolism: after 6 months follow-up
- (and 2 more...)
|
295 |
All |
35 Years and older (Adult, Older Adult) |
NCT02890706 |
NL56542.091.16 |
InSPECT-DECT |
July 7, 2016 |
October 30, 2017 |
October 30, 2017 |
September 7, 2016 |
November 7, 2017 |
|
- Radboudumc
Nijmegen, Gelderland, Netherlands
|
|
| 5 |
NCT02977013 |
Completed |
Anti-Xa Assay Correlation to the Efficacy and Safety of Enoxaparin in the Treatment of Pulmonary Embolism |
- Anti-Xa Assay in Pulmonary Embolism
|
- Diagnostic Test: Anti-Xa assay
|
Observational
|
|
- Mohamed Sayed Mohamed Abbas
- Al Mouwasat Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Recurrent pulmonary embolism
- Platelet count
- Bleeding
- Death
|
42 |
All |
18 Years and older (Adult, Older Adult) |
NCT02977013 |
MSAT-5 |
|
August 2013 |
September 2016 |
September 2016 |
November 30, 2016 |
April 4, 2017 |
|
|
|
| 6 |
NCT01635257 |
Completed |
Accuracy of Multi-organ Ultrasound for the Diagnosis of Pulmonary Embolism |
|
|
Observational
|
|
- Azienda Ospedaliero-Universitaria Careggi
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Accuracy of ultrasound for the diagnosis of pulmonary embolism
|
357 |
All |
18 Years and older (Adult, Older Adult) |
NCT01635257 |
080974 |
SPES |
June 2012 |
December 2012 |
December 2012 |
July 9, 2012 |
March 18, 2013 |
|
- Emergency Department Azienda Ospedaliera Universitaria Careggi
Firenze, Tuscany, Italy - Department of Emergency Medicine, Pierantoni Morgagni Hospital
Forlì, Italy - Department of Emergency Medicine, San Luigi Gonzaga University Hospital
Torino, Italy
|
|
| 7 |
NCT03601676 |
Completed |
Electronic Support for Pulmonary Embolism Emergency Disposition |
|
- Other: Integration of electronic clinical decision support
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Rate of home discharge from the emergency department following treatment for pulmonary embolism
- Number of participants with major hemorrhage, recurrent venous thromboembolism, and all-cause mortality
- Number of participants with return visits for pulmonary embolism-related signs, symptoms, or interventions
|
1703 |
All |
18 Years and older (Adult, Older Adult) |
NCT03601676 |
CN-13-1738-H |
eSPEED |
January 1, 2015 |
April 30, 2016 |
May 30, 2016 |
July 26, 2018 |
July 26, 2018 |
|
- Kaiser Permanente Fremont Emergency Department
Fremont, California, United States - Kaiser Permanente Oakland Emergency Department
Oakland, California, United States - Kaiser Permanente Redwood City Emergency Department
Redwood City, California, United States - (and 11 more...)
|
|
| 8 |
NCT03218566 |
Recruiting |
Evaluating the Safety and Efficacy of the Indigo Aspiration System in Acute Pulmonary Embolism |
|
- Device: Indigo Aspiration System
|
Interventional
|
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- RV/LV ratio
- Major adverse events
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT03218566 |
11373 |
EXTRACT-PE |
November 22, 2017 |
September 2019 |
December 2019 |
July 14, 2017 |
August 24, 2018 |
|
- Baptist Hospital of Miami
Miami, Florida, United States
|
|
| 9 |
NCT01752673 |
Completed |
The Visualization of Uncertainty in Clinical Diagnostic Reasoning for Pulmonary Embolism |
- Pulmonary Embolism
- Diagnostic Uncertainty
- Clinical Reasoning
- (and 2 more...)
|
- Other: Visualized pulmonary embolism computer task model
- Other: Didactic review lecture
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Concordance with medical diagnostic reasoning pathway for pulmonary embolism.
- Time.
|
30 |
All |
24 Years to 65 Years (Adult, Older Adult) |
NCT01752673 |
23231 |
|
March 2011 |
October 2011 |
October 2011 |
December 19, 2012 |
December 19, 2012 |
|
- University of Calgary
Calgary, Alberta, Canada
|
|
| 10 |
NCT02388841 |
Completed |
Thrombus Localization and Accompaying Disorders and Risk Factors |
|
- Radiation: Pulmonary embolism
|
Observational
|
|
- Aysel Sünnetçioğlu
- Yuzuncu Yıl University
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- association between thrombus localization and risk factors, accompanying disorders, D-dimer and red blood cell distribution width (RDW) in patients with pulmonary embolism.
|
148 |
All |
18 Years to 81 Years (Adult, Older Adult) |
NCT02388841 |
YYU-015
YYU-2015-65 |
|
January 2012 |
August 2014 |
August 2014 |
March 17, 2015 |
March 17, 2015 |
|
- Yuzuncu Yil University Hospital
VAN, Tuşba, Turkey
|
|
| 11 |
NCT03754673 |
Not yet recruiting |
Role of MRI in Diagnosis of Pulmonary Embolism |
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- detection of pulmonary embolism by MRI without contrast administration
|
73 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03754673 |
Plumonary MRI |
|
December 1, 2018 |
December 1, 2020 |
December 30, 2020 |
November 27, 2018 |
December 3, 2018 |
|
|
|
| 12 |
NCT03631810 |
Recruiting |
Contemporary Clinical Management Of Acute Pulmonary Embolism |
|
|
Observational
|
|
- Heart Care Foundation
- University Of Perugia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- In-hospital death
- All cause Mortality and clinical worsening
- Pulmonary embolism related mortality for and clinical worsening
- Adherence to guidelines
|
5000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03631810 |
CRU_UniPg_2017 |
COPE |
March 15, 2018 |
December 2020 |
February 2021 |
August 15, 2018 |
August 29, 2018 |
|
- Ospedale San Giovanni Di Dio - Uo Cardiologia E Utic
Agrigento, AG, Italy - Ospedali Riuniti - Sod Ps E Medicina D'Urgenza
Ancona, AN, Italy - Istituto Scientifico Inrca - Uo Cardiologia/Utic/Telecardiologia
Ancona, AN, Italy - (and 204 more...)
|
|
| 13 |
NCT02476721 |
Completed |
Characteristics of Patients With Missed Pulmonary Embolism in the ED: A Three Year Experience |
- Missed Pulmonary Embolism at the Emergency Department
|
- Other: detection of pulmonary embolism
|
Observational
|
|
- University Hospital, Basel, Switzerland
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- in hospital mortality
- initial ED diagnosis
- characteristics of patients with missed PE
|
1251 |
All |
18 Years and older (Adult, Older Adult) |
NCT02476721 |
EKNZ 2014-183 |
|
March 2014 |
March 2015 |
|
June 19, 2015 |
June 19, 2015 |
|
|
|
| 14 |
NCT02355548 |
Completed |
Outpatient Treatment of Low-risk Pulmonary Embolism |
|
- Other: Outpatient Treatment of Pulmonary Embolism
|
Observational
|
|
- Intermountain Health Care, Inc.
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- 90-day all-cause mortality, recurrent VTE, and Major Bleeding during outpatient treatment of Low-risk PE
- Reduction of medical costs due to outpatient treatment.
- Level of patient satisfaction as measured by survey.
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT02355548 |
1018558 |
Low Risk PE |
December 2012 |
December 2017 |
December 2017 |
February 4, 2015 |
November 29, 2018 |
|
- Intermountain Medical Center
Murray, Utah, United States
|
|
| 15 |
NCT01898637 |
Enrolling by invitation |
A Simple Clinical Tool to Help Diagnose Pulmonary Embolism: Phase 1 |
|
- Other: Augmented pulse oximetry using incentive spirometer.
- Device: Incentive spirometer.
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Diagnostic
|
- Change in oxygen saturation using augmented pulse oximetry for patients with and without pulmonary embolism.
- Vital capacity (the maximal amount of air that can be inhaled, measured in milliliters) during augmented pulse oximetry.
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT01898637 |
12-009527 |
|
June 2013 |
June 30, 2019 |
June 30, 2019 |
July 12, 2013 |
December 19, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
|
| 16 |
NCT03579849 |
Recruiting |
Pulmonary Perfusion by Iodine Subtraction Mapping CT Angiography in Acute Pulmonary Embolism |
|
- Diagnostic Test: Pulmonary tomoscintigraphy
|
Interventional
|
Not Applicable |
- University Hospital, Brest
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- The sensitivity of iodine mapping by subtraction technique.
- The specificity of iodine mapping by subtraction technique
- Pulmonary vascular obstruction index
- (and 3 more...)
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03579849 |
29BRC18.0083 (PASEP) |
PASEP |
June 25, 2018 |
April 26, 2019 |
April 26, 2019 |
July 9, 2018 |
October 15, 2018 |
|
|
|
| 17 |
NCT02483442 |
Active, not recruiting |
D-dimer Testing Tailored to Clinical Pretest Probability in Suspected Pulmonary Embolism |
|
|
Observational
|
|
- McMaster University
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of patients with confirmed symptomatic proximal Deep Vein Thrombosis or Pulmonary Embolism
- Number of patients with bleeding
- Number of patient Deaths
- Number of patients with Venous Thromboembolism
|
2038 |
All |
18 Years and older (Adult, Older Adult) |
NCT02483442 |
OCOG-2014-PEGeD |
PEGeD |
December 11, 2015 |
August 2018 |
January 2019 |
June 29, 2015 |
May 11, 2018 |
|
- University of Alberta Hospital
Edmonton, Alberta, Canada - HHS- Hamilton General Hospital
Hamilton, Ontario, Canada - St Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada - (and 6 more...)
|
|
| 18 |
NCT02604238 |
Not yet recruiting |
Efficacy and Safety of Half Dose Alteplase Added to Heparine, in Patients With Moderate Pulmonary Embolism |
|
|
Interventional
|
Phase 3 |
- Azienda U.S.L. 1 di Massa e Carrara
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pulmonary hypertension reduction (systolic pulmonary pressure greater or equal to 30 mm Hg)
- Incidence of recurrent pulmonary embolism fatal or non fatal
- Incidence of hemodynamic shock
- Incidence of hospital death from all causes
|
130 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02604238 |
Azienda USL1 Massa e Carrara |
MONALYSE |
March 2016 |
March 2020 |
March 2021 |
November 13, 2015 |
November 16, 2015 |
|
|
|
| 19 |
NCT03719027 |
Recruiting |
Prevalence of Chronic Thromboembolic Pulmonary Hypertension After Acute Pulmonary Embolism : (Preva-CTEPH) |
- Chronic Thromboembolic Pulmonary Hypertension (CTEPH)
- Pulmonary Embolism
|
- Diagnostic Test: Study population
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
- Merck Sharp & Dohme Corp.
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Cumulated incidence of CTEPH
- Cumulated incidence of CTEPH in patients without previous signs of CTEPH at the time of index PE diagnosis
- Cumulated incidence of CTEPH in patients with previous signs of CTEPH at the time of index PE diagnosis
- (and 3 more...)
|
2200 |
All |
18 Years and older (Adult, Older Adult) |
NCT03719027 |
K161203J
2017-A02047-46 |
Preva-CTEPH |
October 30, 2018 |
December 31, 2020 |
December 31, 2020 |
October 25, 2018 |
February 15, 2019 |
|
- CHU Jean Minjoz
Besançon, France - La Cavale Blanche
Brest, France - Hôpital européen Georges-Pompidou
Paris, France - Hôpital Nord
Saint-Étienne, France
|
|
| 20 |
NCT03023605 |
Completed |
Analysis of a Training Intervention for Pulmonary Embolism Diagnosis in Emergency Department (APEED) |
|
- Behavioral: Training Intervention for PE Diagnosis
|
Interventional
|
Not Applicable |
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Number of cases where clinical guidelines have been followed for suspected Pulmonary Embolism in the Emergency Department (adherence)
- Number of cases where clinical guidelines have been followed for suspected Pulmonary Embolism in the Emergency Department (adherence) after training measures among staff in Emergency Department
- Prevalence of different clinical characteristics of Pulmonary Embolism (presentation, clinical features, treatment, clinical evolution)
- (and 3 more...)
|
440 |
All |
18 Years and older (Adult, Older Adult) |
NCT03023605 |
IIBSP-EPU-2016-61 |
APEED |
November 2016 |
November 2017 |
March 2018 |
January 18, 2017 |
July 2, 2018 |
|
- Hospital de la Santa Creu i Sant Pau
Barcelona, Spain
|
|
| 21 |
NCT00805246 |
Unknown † |
Assessing the Prognosis of Pulmonary Embolism Using Clinical and Imaging Biomarkers (Retrospective & Prospective ) |
|
|
Observational
|
|
- University of Pittsburgh
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
|
- The clinical and Imaging Biomarkers associated with Pulmonary Embolism (PE).
- Pulmonary Embolism (PE) risk prediction rule.
|
910 |
All |
18 Years and older (Adult, Older Adult) |
NCT00805246 |
HL095115 |
|
December 2008 |
July 2013 |
July 2017 |
December 9, 2008 |
October 27, 2016 |
|
- Washington University in St. Louis
St. Louis, Missouri, United States - University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
|
| 22 |
NCT02883491 |
Recruiting |
Pulmonary Embolism Short-term Clinical Outcomes Registry |
|
|
Observational
|
|
- Carolinas Healthcare System
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Clinical Deterioration
- Right ventricular dysfunction (RVD)
- Functional Outcome
- Pulmonary Embolism Complications
|
880 |
All |
18 Years and older (Adult, Older Adult) |
NCT02883491 |
07-16-06E |
PE-SCOR |
August 2016 |
March 2020 |
March 2020 |
August 30, 2016 |
July 19, 2018 |
|
- Banner University Medical Center
Tucson, Arizona, United States - San Diego Medical Center
San Diego, California, United States - Christiana Care Health System
Newark, Delaware, United States - (and 4 more...)
|
|
| 23 |
NCT02430207 |
Unknown † |
Incidence of Pulmonary Embolism During Temporary Pacing Via Femoral Versus Subclavian Vein |
|
- Procedure: temporary pacing femoral vein
- Procedure: temporary pacing subclavian vein
|
Interventional
|
Not Applicable |
- The First Affiliated Hospital with Nanjing Medical University
- Suqian People's Hospital
- The First people's Hospital of Kunshan
- (and 13 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage of participants suffering from pulmonary embolism
- Percentage of participants suffering from deep vein thrombosis
|
360 |
All |
18 Years and older (Adult, Older Adult) |
NCT02430207 |
KFSN201407 |
|
May 2015 |
May 2016 |
|
April 30, 2015 |
February 19, 2016 |
|
|
|
| 24 |
NCT02758574 |
Recruiting |
Standard vs. Ultrasound-assisted Catheter Thrombolysis for Submassive Pulmonary Embolism |
|
- Procedure: CDT without ultrasound acceleration
- Procedure: CDT with ultrasound acceleration
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- PE thrombus load reduction (CT obstruction index) from baseline to the termination of lysis
- Mortality
- Stroke
- (and 8 more...)
|
80 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02758574 |
PRO15090058 |
SUNSET sPE |
May 2016 |
April 2019 |
April 2019 |
May 2, 2016 |
May 8, 2018 |
|
- UPMC Presbyterian
Pittsburgh, Pennsylvania, United States - UPMC Mercy
Pittsburgh, Pennsylvania, United States - UPMC Shadyside
Pittsburgh, Pennsylvania, United States - UPMC Passavant
Pittsburgh, Pennsylvania, United States
|
|
| 25 |
NCT01727427 |
Completed |
Prospective Study on the Treatment of Unsuspected Pulmonary Embolism in Cancer Patients |
- Unsuspected Pulmonary Embolism
|
- Drug: Heparin, fondaparinux, vitamin-K antagonists, aspirin
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Recurrent (symptomatic) vein thromboembolism, including pulmonary embolism and deep vein thrombosis
- Major, clinically relevant non-major bleeding, and minor bleeding
|
695 |
All |
18 Years and older (Adult, Older Adult) |
NCT01727427 |
215/2012 |
|
November 2012 |
December 2017 |
December 2017 |
November 16, 2012 |
May 9, 2018 |
|
- D.C. Veterans Affairs Medical Center
Washington, District of Columbia, United States - Clinical Division of Haematology, Department of Medicine I
Vienna, Austria - Division of Hematology, University of Ottawa
Ottawa, Canada - (and 43 more...)
|
|
| 26 |
NCT02190110 |
Completed |
Pulmonary Embolism Diagnosis: Ultrasound Wells Score vs Traditional Wells Score |
|
|
Observational
|
|
- Azienda Ospedaliero-Universitaria Careggi
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- ultrasound Wells score vs traditional Wells score diagnostic performance.
- Failure rate and efficiency of traditional and US Wells
|
444 |
All |
18 Years and older (Adult, Older Adult) |
NCT02190110 |
1001 |
|
August 2014 |
July 2015 |
July 2015 |
July 15, 2014 |
February 9, 2016 |
|
- Azienda Ospedaliera Universitaria Careggi
Firenze, Italy - Ospedale San Paolo, Università degli studi di Milano
Milano, Italy - Department of Internal Medicine, Università degli studi di Perugia
Perugia, Italy - Azienda Ospedaliera Universitaria San Luigi Gonzaga
Torino, Italy
|
|
| 27 |
NCT03316729 |
Withdrawn |
DS-9231 in Intermediate-risk (Sub-massive) Acute Pulmonary Embolism (PE) |
|
- Drug: DS-9231
- Drug: Placebo
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Percent change from baseline in total thrombus volume
- Percentage of participants with various gradations of decrease in total thrombus volume
- Number of participants with major or clinically relevant nonmajor bleeding
- (and 12 more...)
|
0 |
All |
18 Years and older (Adult, Older Adult) |
NCT03316729 |
DS9231-A-U201
2017-000552-25 |
|
January 2018 |
February 2020 |
February 2020 |
October 20, 2017 |
December 24, 2018 |
|
|
|
| 28 |
NCT01097928 |
Recruiting |
Pulmonary Embolism Response to Fragmentation, Embolectomy, & Catheter Thrombolysis: PERFECT |
|
- Procedure: Catheter directed debulking of Pulmonary Embolus
|
Observational
|
|
- Stanford University
- Adventist Midwest Health
- Weill Medical College of Cornell University
- (and 3 more...)
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Resolution of hypoxia
- Survival from acute PE
- Stabilization of hemodynamics
- Clinical practice patterns across centers
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT01097928 |
SU-03292010-5502
eProtocol ID 14793 |
|
January 2010 |
January 2020 |
January 2020 |
April 2, 2010 |
April 18, 2018 |
|
- Stanford University School of Medicine
Stanford, California, United States
|
|
| 29 |
NCT01939301 |
Completed
Has Results |
Nitric Oxide to Treat Pulmonary Embolism |
|
- Drug: Inhaled Nitric Oxide
- Drug: Sham
|
Interventional
|
Phase 2 |
- Indiana University School of Medicine
- Mallinckrodt
- National Institutes of Health (NIH)
- (and 4 more...)
|
Other / Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Number of Participants With Normal Right Ventricular (RV) Function and Viability
|
78 |
All |
18 Years and older (Adult, Older Adult) |
NCT01939301 |
Kline-1UM NO for PE
1UM1HL113203-01A1 |
|
October 2013 |
October 31, 2016 |
October 31, 2016 |
September 11, 2013 |
October 3, 2018 |
March 29, 2018 |
- Eskenazi Hospital
Indianapolis, Indiana, United States - Indiana University Hospital
Indianapolis, Indiana, United States - Methodist Hospital
Indianapolis, Indiana, United States - University of Mississippi
Jackson, Mississippi, United States
|
|
| 30 |
NCT00455819 |
Completed |
Home Treatment of Patients With Pulmonary Embolism Based on Pro-Brain Natriuretic Peptide (BNP) Levels |
|
- Procedure: home treatment
|
Interventional
|
Not Applicable |
- St. Antonius Hospital
- Diakonessenhuis, Utrecht
- Groene Hart Ziekenhuis
- Reinier de Graaf Hospital, Delft
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mortality rate due to pulmonary embolism or its treatment during a period of ten days in the outpatient group
- Rate of re-admission due to pulmonary embolism or its treatment in the outpatient group: hemodynamic instability, major bleeding, recurrence of venous thromboembolism
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT00455819 |
LTME/VL-06.12
HOME |
|
December 2006 |
March 2009 |
March 2009 |
April 4, 2007 |
March 31, 2009 |
|
- St Antonius Hospital
Nieuwegein, Netherlands - Mesos Medical Centre
Utrecht, Netherlands
|
|
| 31 |
NCT01458639 |
Terminated
Has Results |
Compare Technegas Ventilation-Perfusion SPECT and Xenon Ventilation-Perfusion Planar Imaging for Pulmonary Embolism |
|
- Drug: Technegas V SPECT imaging
- Drug: Xenon-133 Ventilation Planar imaging
|
Interventional
|
Phase 3 |
- Cyclomedica Australia PTY Limited
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Sensitivity of Technegas V/Q SPECT for the Diagnosis of PE
- Specificity of Technegas V/Q SPECT for the Diagnosis of PE.
- Accuracy of Technegas V/Q SPECT and Xenon V/Q Planar Imaging for Diagnosis of PE
- (and 4 more...)
|
18 |
All |
18 Years and older (Adult, Older Adult) |
NCT01458639 |
CYC-008 |
|
August 2012 |
June 2015 |
June 2015 |
October 25, 2011 |
November 10, 2015 |
November 10, 2015 |
- Barnes-Jewish Hospital, Washington University
St. Louis, Missouri, United States - Columbia University Medical Center
New York, New York, United States
|
|
| 32 |
NCT03595085 |
Not yet recruiting |
Catheter Directed Interventions in Pulmonary Embolism |
|
- Procedure: catheter directed fragmentation and thrombolysis
- Drug: Streptokinase
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 30-day mortality
- Changes in blood pressure
- oxygen saturation
- changes in right ventricular dysfunction
|
60 |
All |
Child, Adult, Older Adult |
NCT03595085 |
CTPE |
|
September 1, 2018 |
October 1, 2020 |
March 1, 2021 |
July 23, 2018 |
July 24, 2018 |
|
|
|
| 33 |
NCT02132689 |
Completed |
Comparison of Thrombgolytic and Anticoagulation Therapy in Submassive Pulmonary Embolism |
|
- Drug: Actilyse (Thrombolytic therapy)
- Drug: Heparine (Standard anticoagulation therapy)
|
Interventional
|
Phase 4 |
- University Hospital Ostrava
- Municipal Hospital Ostrava Fifejdy
- Silesian Hospital Opava
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical manifestations of right ventricular failure and pulmonary hypertension and cardiovascular-related death
- Pulmonary hypertension
- Cardiovascular-related deaths
- Echocardiographic manifestations of right ventricular failure and pulmonary hypertension.
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT02132689 |
FNO-KVO-3 |
CONTACT-SPE |
March 2011 |
May 2015 |
December 2015 |
May 7, 2014 |
March 19, 2018 |
|
- Silesian Hospital Opava
Opava, Czechia - University Hospital Ostrava
Ostrava-Poruba, Czechia
|
|
| 34 |
NCT01318174 |
Completed |
Pulmonary Embolism in Exacerbations of Chronic Obstructive Pulmonary Disease |
- Pulmonary Embolism
- Chronic Obstructive Pulmonary Disease
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Prevalence of pulmonary embolism in exacerbations of COPD
|
38 |
All |
18 Years and older (Adult, Older Adult) |
NCT01318174 |
LE-KE |
|
April 2011 |
April 2012 |
April 2013 |
March 18, 2011 |
July 8, 2014 |
|
- Sykehuset Innlandet
Lillehammer, Oppland, Norway
|
|
| 35 |
NCT03487237 |
Completed |
Prevalence of PE in ED Patients With Isolated Syncope |
|
- Biological: Ddimer testing
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- diagnosis of Pulmonary embolism within 72 hrs after ED visit Safety
- Validation of usual clinical decision rules-Wells
- Validation of usual clinical decision rules-Revised Geneva Score
- (and 3 more...)
|
459 |
All |
18 Years and older (Adult, Older Adult) |
NCT03487237 |
K171102J |
PEEPS |
May 23, 2018 |
December 18, 2018 |
December 18, 2018 |
April 3, 2018 |
December 27, 2018 |
|
- Hôpital Saint Antoine
Paris, France
|
|
| 36 |
NCT01604538 |
Completed |
Italian Pulmonary Embolism Registry - IPER |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
1700 |
All |
18 Years and older (Adult, Older Adult) |
NCT01604538 |
protocol_364 |
IPER |
March 2006 |
|
|
May 23, 2012 |
May 23, 2012 |
|
|
|
| 37 |
NCT01908231 |
Completed |
Prognostic Value of Plasma Lactate Levels Among Patients With Acute Pulmonary Embolism |
|
|
Observational
|
|
- Azienda Ospedaliero-Universitaria Careggi
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The composite of PE related death or hemodynamic collapse
- all cause death
- PE recurrence
|
330 |
All |
18 Years and older (Adult, Older Adult) |
NCT01908231 |
0313 |
TELOS |
December 2012 |
January 2014 |
February 2014 |
July 25, 2013 |
February 19, 2014 |
|
- Azienda Ospedaliero Universitaria Careggi, Emergency Department
Florence, Italy - Presidio Ospedaliero Livorno
Livorno, Italy - Azienda ospedaliera universitaria San Giovanni Battista (Molinette)
Torino, Italy - Respiratory Department and Medicine Department, Ramón y Cajal Hospital and Alcalá de Henares University
Madrid, Spain
|
|
| 38 |
NCT01633671 |
Completed |
NT-proBNP as a Tool for the Detection of Acute Pulmonary Artery Embolism (APE) |
- Pulmonary Embolism
- Pulmonary Embolism Without Mention of Acute Cor Pulmonale
|
|
Observational
|
|
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Acute pulmonary embolism: CT-proof yes vs. no
|
44 |
All |
Child, Adult, Older Adult |
NCT01633671 |
ana-ulm-ntprobnp-288/11 |
|
November 2008 |
December 2011 |
December 2011 |
July 4, 2012 |
July 6, 2012 |
|
- University of Ulm, Michelsberg anaesthesiologic ICU
Ulm, Baden-Wuerttemberg, Germany
|
|
| 39 |
NCT03274401 |
Recruiting |
Screening for Atrial Fibrillation in Pulmonary Embolism Study -SAFE-PE Study |
- Atrial Fibrillation
- Pulmonary Embolism
|
- Device: Zenicor intermittent ECG device
|
Interventional
|
Not Applicable |
- Danderyd Hospital
- Karolinska Institutet
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Mortality
- Mortality and thromboembolic events
|
800 |
All |
Child, Adult, Older Adult |
NCT03274401 |
SAFE-PE |
SAFE-PE |
September 13, 2017 |
September 11, 2022 |
September 2027 |
September 7, 2017 |
February 7, 2019 |
|
- Danderyd Hospital
Stockholm, Sweden
|
|
| 40 |
NCT03101384 |
Recruiting |
Influence of Diagnostic Errors on the Prognosis of Acute Pulmonary Embolism |
- Pulmonary Embolism
- Pulmonary Embolism and Thrombosis
- Diagnostic Errors
- (and 2 more...)
|
|
Observational
|
|
- European Georges Pompidou Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Severity of pulmonary embolism at the time of diagnosis
- Complication of pulmonary embolism
- Frequency of diagnostic errors
- Characteristic of patient with diagnosis errors
|
302 |
All |
18 Years and older (Adult, Older Adult) |
NCT03101384 |
N° ID RCB : 2017-A00433-50 |
IDEA-PE |
April 11, 2017 |
October 2018 |
April 2019 |
April 5, 2017 |
June 2, 2017 |
|
- Hôpital européen Georges Pompidou
Paris, Ile de France, France
|
|
| 41 |
NCT03426124 |
Recruiting |
An International Pulmonary Embolism Registry Using EKOS |
- Pulmonary Embolism and Thrombosis
|
- Device: EkoSonic Endovascular System with thrombolytic
|
Observational
|
|
- EKOS Corporation
- BTG International Inc.
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Change in the ratio of the measurement of the right ventricular to left ventricular diameters (RV/LV) as measured by echocardiogram
- Persistence of pulmonary hypertension defined as mean pulmonary artery pressure greater than 25mm Hg by echocardiogram
- Other urgent interventions for index PE
- (and 8 more...)
|
1500 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03426124 |
BTG-001653-01 |
KNOCOUT PE |
March 1, 2018 |
March 10, 2020 |
March 1, 2021 |
February 8, 2018 |
May 30, 2018 |
|
- Inova Alexandria Hospital
Springfield, Virginia, United States
|
|
| 42 |
NCT00615147 |
Completed |
Accuracy of the D-Dimer Assay for the Exclusion of Pulmonary Embolism in a High Risk Oncologic Population |
|
- Procedure: CT pulmonary angiogram and d-dimer draw
|
Observational
|
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The negative predictive value of the d-dimer assay relative to CT pulmonary angiogram will be the primary measure of accuracy used for this purpose.
- To estimate the positive predictive value, sensitivity, and specificity of the d-dimer assay relative to CT pulmonary angiogram.
- To explore the association between the accuracy of the d-dimer assay and clinical symptoms indicating pulmonary embolism.
|
213 |
All |
21 Years and older (Adult, Older Adult) |
NCT00615147 |
05-040 |
|
May 2005 |
June 2008 |
June 2008 |
February 14, 2008 |
January 9, 2012 |
|
- Memorial Sloan-Kettering Cancer Center
New York, New York, United States
|
|
| 43 |
NCT02946944 |
Recruiting |
Sidlenafil in Combination With Oral Anticoagulants in Patients With Intermediate-high Risk of Pulmonary Embolism |
- Pulmonary Embolism
- Intermediate-high Risk
- Combination of Oral Anticoagulation Therapy and Sildenafil
|
- Drug: Sildenafil/apixaban
- Drug: apixaban
|
Interventional
|
Phase 1 |
- Meshalkin Research Institute of Pathology of Circulation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- MSCT RV \ LV Index
- Echocardiogram RV \ LV Index
- Echocardiogram pressure in the pulmonary artery
- (and 5 more...)
|
100 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02946944 |
NRICP-45734 |
PSCAT |
October 2016 |
October 2020 |
October 2020 |
October 27, 2016 |
November 1, 2016 |
|
- Federal State Institution Academician E.N.Meshalkin Novosibirsk State Research Institute Of Circulation Pathology Rusmedtechnology
Novosibirsk, Russian Federation
|
|
| 44 |
NCT03275610 |
Enrolling by invitation |
Genetic Markers of Patients With History of Pulmonary Embolism Post Total Joint Arthroplasty |
|
|
Observational
|
|
- University of Southern California
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Identification of Genetic Mutations
|
100 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03275610 |
ORTHO-01 |
|
April 24, 2017 |
April 23, 2018 |
April 23, 2018 |
September 7, 2017 |
September 7, 2017 |
|
- University of Southern California
Los Angeles, California, United States
|
|
| 45 |
NCT02584660 |
Completed
Has Results |
A Study of Rivaroxaban for Early Discharge of Low Risk Pulmonary Embolism From the Emergency Department |
|
- Drug: Rivaroxaban
- Drug: Standard-of-care
|
Interventional
|
Phase 4 |
- Janssen Scientific Affairs, LLC
- Bayer
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean Duration of Hospitalization
- Percentage of Participants With Reoccurrence of Symptomatic Venous Thromboembolism Event (VTE) (Composite of Recurrent PE, New or Recurrent DVT) or VTE-related Death
- Percentage of Participants With Number of Unplanned Hospital Visits or Physician Office for VTE Symptoms and/or Bleeding
- (and 3 more...)
|
114 |
All |
18 Years and older (Adult, Older Adult) |
NCT02584660 |
CR107694
39039039APE4001 |
MERCURY PE |
October 15, 2015 |
March 22, 2017 |
March 22, 2017 |
October 22, 2015 |
June 1, 2018 |
April 20, 2018 |
- Montgomery, Alabama, United States
- Chandler, Arizona, United States
- Phoenix, Arizona, United States
- (and 47 more...)
|
|
| 46 |
NCT02652689 |
Terminated |
Diagnosis of Pulmonary Embolism by Doppler Signals |
|
- Radiation: Diagnostic ultrasound radiation
|
Interventional
|
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Identify lack of Lung Doppler signals in specific lung sections that were diagnosed obstructed by CT
|
25 |
All |
18 Years and older (Adult, Older Adult) |
NCT02652689 |
DOP023 |
|
April 2016 |
December 2018 |
January 2019 |
January 12, 2016 |
February 8, 2019 |
|
|
|
| 47 |
NCT00425542 |
Completed |
Safety Study of Outpatient Treatment for Pulmonary Embolism |
|
- Other: Outpatient care (vs traditional inpatient care)
|
Interventional
|
Phase 3 |
- University of Lausanne Hospitals
- Swiss National Science Foundation
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Recurrent, symptomatic venous thromboembolism (deep vein thrombosis or pulmonary embolism)
- Major bleeding
- All-cause mortality
- (and 2 more...)
|
343 |
All |
18 Years and older (Adult, Older Adult) |
NCT00425542 |
3200B0-112165
1R01HL085565-01A2 |
OTPE |
January 2007 |
June 2010 |
June 2010 |
January 23, 2007 |
June 11, 2010 |
|
- Northwestern Memorial Hospital
Chicago, Illinois, United States - Carolinas Medical Center
Charlotte, North Carolina, United States - UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States - (and 16 more...)
|
|
| 48 |
NCT02460952 |
Unknown † |
The Clinic Study to Prevent Pulmonary Embolism in Patients With General Anesthesia Operation in Perioperative Period |
|
|
Observational
|
|
- Beijing Chao Yang Hospital
|
Other |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- The changes of patients'Lower extremity vein in perioperative period of general anesthesia operation
|
500 |
All |
45 Years to 85 Years (Adult, Older Adult) |
NCT02460952 |
22704102 |
|
August 2014 |
January 2016 |
August 2016 |
June 3, 2015 |
June 3, 2015 |
|
- Liu Sijie
Beijing, Beijing, China
|
|
| 49 |
NCT02811237 |
Recruiting |
Hospitalization or Out-treatment ManagEment of Patients With Pulmonary Embolism: a Randomized Controlled Trial |
|
- Other: HESTIA
- Other: sPESI
|
Interventional
|
Not Applicable |
- University Hospital, Angers
- European Georges Pompidou Hospital
- Hospital Universitario Ramon y Cajal
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- The rate of the composite of recurrent VTE, major bleeding and all cause death at 30 days
- The rate of patients actually managed as outpatients (meaning patients discharged home within 24 hours after the inclusion in the study (first major secondary objective))
- The rate of "low-risk" patients in theory eligible for outpatient care (second major secondary objective)
- (and 11 more...)
|
1975 |
All |
18 Years and older (Adult, Older Adult) |
NCT02811237 |
PHRC 2015-04 |
HOME-PE |
January 2017 |
April 2019 |
June 2019 |
June 23, 2016 |
August 15, 2018 |
|
- Cliniques Universitaires Saint-Luc
Brussels, Belgium - Hôpital Erasme
Bruxelles, Belgium - Hôpital Saint-Pierre
Bruxelles, Belgium - (and 25 more...)
|
|
| 50 |
NCT00711308 |
Completed |
Tinzaparin in the Treatment of the Acute Pulmonary Embolism |
|
- Drug: tinzaparin
- Drug: acenocoumarol
|
Interventional
|
Phase 4 |
- Complejo Hospitalario Xeral-Calde
- LEO Pharma
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility of the secondary prophylaxis of pulmonary embolism with tinzaparin
- direct and indirect cost of each treatment regimen
- Major haemorrhagic events
|
102 |
All |
18 Years and older (Adult, Older Adult) |
NCT00711308 |
EX0401ES
eudract-no. 2004-002019-97 |
|
April 2005 |
January 2009 |
February 2009 |
July 8, 2008 |
February 13, 2009 |
|
- Pneumology Service. Hospital Clínico
Santiago de Compostela, A Coruña, Spain - Pneumology Service. Hospital Xeral Cies
Vigo, Pontevedra, Spain - Pneumology Service. Hospital do Meixoeiro
Vigo, Pontevedra, Spain - Pneumology Service
Lugo, Spain
|
|
| 51 |
NCT01516814 |
Completed |
Venous Thromboembolism (VTE) Treatment Study in Japanese Pulmonary Embolism (PE) Patients |
|
- Drug: Rivaroxaban (Xarelto, BAY59-7939)
- Drug: Unfractionated heparin
- Drug: Warfarin
|
Interventional
|
Phase 3 |
- Bayer
- Janssen Research & Development, LLC
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with newly onset of symptomatic venous thromboembolism (VTE)
- Number of clinically relevant bleedings
- Number of participants with improvement in thrombotic burden
- (and 2 more...)
|
40 |
All |
20 Years and older (Adult, Older Adult) |
NCT01516814 |
15960 |
|
February 2012 |
October 2013 |
November 2013 |
January 25, 2012 |
January 23, 2017 |
|
- Nagoya, Aichi, Japan
- Toyoake, Aichi, Japan
- Sakura, Chiba, Japan
- (and 28 more...)
|
|
| 52 |
NCT02261610 |
Recruiting |
Pulmonary Embolism and PCT. PE-PCT Study |
- Pulmonary Embolism With Fever
|
- Procedure: Procalcitonin algorithm
|
Interventional
|
Not Applicable |
- University Hospital, Clermont-Ferrand
- Thermo Fisher Scientific
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Percentage of patient treated by antibiotics in each group
- Percentage of death
- Percentage of antibiotics stop
- Rate of new hospitalization during the following month
|
62 |
All |
18 Years and older (Adult, Older Adult) |
NCT02261610 |
CHU-0203
2014-A00046-41 |
|
November 26, 2014 |
December 2019 |
December 2019 |
October 10, 2014 |
February 9, 2018 |
|
- CHU Clermont-Ferrand
Clermont-Ferrand, France
|
|
| 53 |
NCT03405480 |
Recruiting |
Pulmonary Rehabilitation to Improve Physical Capacity After Pulmonary Embolism |
|
|
Interventional
|
Not Applicable |
- Ostfold Hospital Trust
- University Hospital, Akershus
- Ullevaal University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- ISWT
- mMRC
- Sensewear
- (and 6 more...)
|
190 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03405480 |
2017/1940 (REK) |
|
January 20, 2018 |
June 1, 2019 |
December 31, 2020 |
January 23, 2018 |
March 15, 2018 |
|
- The hospital of Østfold, Kalnes
Grålum, Norway
|
|
| 54 |
NCT00378027 |
Withdrawn |
Arixtra PE Study- Outpatient Management of Stable Acute Pulmonary Embolism: Once Daily Subcutaneous Fondaparinux |
|
|
Observational
|
|
- The Cleveland Clinic
- GlaxoSmithKline
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
0 |
All |
18 Years and older (Adult, Older Adult) |
NCT00378027 |
05-202 |
|
August 2006 |
April 2007 |
April 2007 |
September 19, 2006 |
January 27, 2017 |
|
- Cleveland Clinic 9500 Euclid Ave.
Cleveland, Ohio, United States
|
|
| 55 |
NCT02684721 |
Completed |
Does a Home-based Exercise Programme Affect Physical Capacity and Quality of Life in Patients With Pulmonary Embolism? |
|
- Other: 8-week home-based exercise programme
|
Interventional
|
Not Applicable |
- Central Jutland Regional Hospital
- Aalborg Universitetshospital
- Horsens Hospital
- Regional Hospital West Jutland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Incremental Shuttle Walk test from baseline to 6 months after baseline
- Change in Pulmonary Embolism Quality of Life from baseline to 6 months
- Change in EuroQol 5 Dimensions (EQ-5D) from baseline to 6 months
- (and 2 more...)
|
140 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02684721 |
6300001 |
|
April 1, 2016 |
September 1, 2018 |
September 1, 2018 |
February 18, 2016 |
December 21, 2018 |
|
- Aalborg University Hospital
Aalborg, Denmark - Regional hospital Herning
Herning, Denmark - Diagnostic Centre, Regional Hospital Silkeborg
Silkeborg, Denmark
|
|
| 56 |
NCT03091621 |
Recruiting |
Japanese Registry of Rivaroxaban Effectiveness & Safety for the Prevention of Recurrence in Patients With Deep Vein Thrombosis and Pulmonary Embolism |
- Deep Vein Thrombosis
- Pulmonary Embolism
|
|
Observational
|
|
- Nihon University
- Mebix Inc
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Recurrence/exacerbation of symptomatic venous thromboembolism (VTE)
- Onset/exacerbation of symptomatic pulmonary embolism (PE)
- Onset/exacerbation of symptomatic deep vein thrombosis (DVT)
- (and 12 more...)
|
1000 |
All |
Child, Adult, Older Adult |
NCT03091621 |
J'xactly |
|
December 2016 |
November 2019 |
November 2019 |
March 27, 2017 |
March 29, 2017 |
|
- Nihon University School of Medicine
Tokyo, Itabashi-ku, Japan
|
|
| 57 |
NCT02238639 |
Recruiting |
Pulmonary Embolism as a Cause of COPD Exacerbations |
- Pulmonary Embolism
- Chronic Obstructive Pulmonary Disease
|
- Procedure: Diagnostic and therapeutic strategy: Highly sensitive D-dimer testing and, if positive, multidetector computed tomographic pulmonary angiography (MDCT).
|
Interventional
|
Phase 3 |
- Ministry of Health, Spain
- American College of Chest Physicians
- Sociedad Española de Neumología y Cirugía Torácica
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- All-cause mortality, symptomatic venous thromboembolism recurrence, or need for readmission.
- All-cause mortality
- Symptomatic recurrent venous thromboembolism
- (and 4 more...)
|
900 |
All |
18 Years and older (Adult, Older Adult) |
NCT02238639 |
SLICE 1 |
SLICE |
October 2014 |
October 2018 |
December 2018 |
September 12, 2014 |
September 6, 2017 |
|
- Hospital Germans Trias i Pujol
Badalona, Barcelona, Spain - Hospital Galdakao
Baracaldo, Spain - Clinica Nostra Senyora del Remei
Barcelona, Spain - (and 16 more...)
|
|
| 58 |
NCT01113775 |
Unknown † |
Pulmonary Embolism: Multifunctional Assessment of Prognosis |
|
|
Observational
|
|
- University Of Perugia
- Clinical Research Unit
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
400 |
All |
18 Years and older (Adult, Older Adult) |
NCT01113775 |
CRU Unipg 02-06 |
PE-MAP |
January 2007 |
|
|
April 30, 2010 |
May 17, 2010 |
|
- Internal and Cardiovascular Medicine Department
Perugia, Italy
|
|
| 59 |
NCT03672123 |
Not yet recruiting |
GDF-15 Levels in Risk Stratification in Acute Pulmonary Embolism |
|
|
Observational
|
|
- Medical University of Warsaw
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- hemodynamic deterioration
- Hemorrhagic complications
|
270 |
All |
18 Years and older (Adult, Older Adult) |
NCT03672123 |
GDF-15 APE |
|
October 1, 2018 |
January 1, 2021 |
June 1, 2021 |
September 14, 2018 |
September 14, 2018 |
|
|
|
| 60 |
NCT02035293 |
Completed |
Frequency of Diagnostic Symptomatic Pulmonary Embolism's in Patients Hospitalized for Clinical Exacerbation of Chronic Obstructive Pulmonary Disease (COPD) |
- Chronic Obstructive Pulmonary Disease
- Patients Hospitalized for a COPD Exacerbation
|
|
Interventional
|
Not Applicable |
- University Hospital, Brest
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Frequency of pulmonary embolism in patients hospitalized for a clinical exacerbation of COPD.
- The rate of pulmonary embolism diagnosed during the 3 month follow-up in patients whom pulmonary embolism was initially excluded when they've been included in the study
|
750 |
All |
18 Years and older (Adult, Older Adult) |
NCT02035293 |
PEP
RB 13-087 [CHRU Brest] |
PEP |
January 8, 2014 |
October 13, 2017 |
October 13, 2017 |
January 14, 2014 |
December 29, 2017 |
|
- CHU
Angers, France - CHRU de Brest
Brest, France - HIA
Brest, France - (and 4 more...)
|
|
| 61 |
NCT03108833 |
Recruiting |
A Trial in Recombinant Human Prourokinase to Treat Acute Pulmonary Embolism |
|
- Drug: Recombinant Human Prourokinase
- Drug: Alteplase
|
Interventional
|
Phase 2 |
- Tasly Pharmaceuticals, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Qanadli CT Score
- Average pulmonary artery pressure
- Three tricuspid regurgitation velocity
- (and 7 more...)
|
108 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03108833 |
TASLY-B1448 |
ERUPTE |
May 9, 2017 |
July 2018 |
February 2019 |
April 11, 2017 |
February 5, 2018 |
|
- Fuwai Hospital
Beijing, Beijing, China - Anzhen Hospital, Capital Medical University
Beijing, Beijing, China - Beijing Shijitan Hospital,Capital Medical University
Beijing, Beijing, China - (and 16 more...)
|
|
| 62 |
NCT01457963 |
Completed |
Prevalence of Pulmonary Embolism in ICU |
- Pulmonary Embolism
- Deep Venous Thrombosis
|
|
Observational
|
|
- University Hospital, Grenoble
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Find a pulmonary embolism on the CT scan
- To find thrombus on compression ultrasound (CUS) of the four limbs
|
176 |
All |
18 Years and older (Adult, Older Adult) |
NCT01457963 |
5891 |
PEICU |
December 2009 |
April 2011 |
April 2011 |
October 24, 2011 |
October 24, 2011 |
|
- University hospital of grenoble
Grenoble, France
|
|
| 63 |
NCT00565253 |
Completed |
Inhaled Nitric Oxide in Pulmonary Embolism |
|
- Drug: Inhaled nitric oxide (NO)
|
Interventional
|
Phase 2 |
- Medical University of Vienna
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- right ventricular size and arterial oxygenation
- blood pressure, central venous pressure, right ventricular function, pulmonary artery pressure
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT00565253 |
3052001 |
|
March 2005 |
July 2009 |
December 2009 |
November 29, 2007 |
June 23, 2010 |
|
- University of Emergency Medicine, Medical University of Vienna
Vienna, Austria
|
|
| 64 |
NCT01781858 |
Completed |
Study on the Clinical Course Of Pulmonary Embolism |
- Cardiovascular Diseases
- Venous Thromboembolism
- Pulmonary Hypertension
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of chronic thromboembolic pulmonary hypertension
- Incidence of recurrent venous thromboembolic events
|
700 |
All |
18 Years and older (Adult, Older Adult) |
NCT01781858 |
Scope-001 |
SCOPE |
January 2008 |
May 2014 |
July 2014 |
February 1, 2013 |
June 14, 2016 |
|
|
|
| 65 |
NCT01326507 |
Completed |
Prognostic Value of Heart-type Fatty Acid-Binding Protein (h-FABP) in Acute Pulmonary Embolism |
|
- Biological: Dosage de l'h-FABP
|
Interventional
|
Not Applicable |
- University Hospital, Toulouse
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- number of death by pulmonary embolism
- life-threatening pulmonary embolism (cardiopulmonary arrest, shock, mechanical ventilation)
- recurrent episode of pulmonary embolism
- prognostic value of a clinical score (PESI), BNP and troponin in acute pulmonary embolism
|
165 |
All |
18 Years and older (Adult, Older Adult) |
NCT01326507 |
0900303
2009-A00441-56 |
|
September 2009 |
June 2011 |
December 2011 |
March 31, 2011 |
May 12, 2017 |
|
- Hôpital Rangueil Service des urgences
Toulouse, France
|
|
| 66 |
NCT02059551 |
Active, not recruiting |
Magnetic Resonance Imaging Combined With Venous Ultrasonography of the Legs for Pulmonary Embolism |
|
- Procedure: MRI combined with venous ultrasonography of the legs
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- To assess diagnostic performances of MRI combined with venous ultrasonography of the legs in reference to Multi-Detector Computed Tomography and 3 months clinical follow-up
- To assess the diagnostic accuracy of a strategy combining clinical probability, D-dimer measurement, MRI and venous ultrasonography of the legs for PE
- To assess diagnostic performances of each MRI sequence combined or not to venous ultrasonography of the legs in reference to Multi-Detector Computed Tomography and 3 months clinical follow-up
- inter-reader agreement for MRI
|
1058 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT02059551 |
P120133 |
IRM-EP2 |
August 2013 |
November 28, 2018 |
November 28, 2018 |
February 11, 2014 |
October 2, 2018 |
|
- Hôpital Européen Georges Pompidou
Paris, France
|
|
| 67 |
NCT02438462 |
Recruiting |
Soluble Fibrin for Diagnosing Pulmonary Embolism |
|
|
Observational
|
|
- Diagnostica Stago R&D
- European Georges Pompidou Hospital
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Area under the ROC curve of the Soluble Fibrin for the diagnosis of PE
- Threshold of the Soluble Fibrin assays for the diagnosis of PE
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02438462 |
SOFIE 2015-A00094-45 |
SOFIE |
June 2015 |
October 2017 |
October 2017 |
May 8, 2015 |
March 28, 2017 |
|
- Georges Pompidou European Hospital
Paris, France
|
|
| 68 |
NCT02268903 |
Recruiting |
Diuretic Versus Placebo in Pulmonary Embolism |
- Pulmonary Embolism With Right Ventricle Enlargement
|
- Drug: Diuretics : Furosemide
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Primary end point will be a combined clinical criterion, to reach the primary endpoint, patients have to meet all the following criteria: - Urine output> 0.5ml/kg/h - Normalization of clinical parameters of simplified PESI score
- patients have to meet all the four following criteria: - Urine output> 0.5ml/kg/h over 24 hours - Normalization of clinical parameters of simplified PESI score - Urine output
- - Composite criteria including death, need for catecholamine, cardiac arrest and mechanical ventilation during hospitalization and at 1 month from inclusion - NYHA score
- (and 2 more...)
|
270 |
All |
18 Years and older (Adult, Older Adult) |
NCT02268903 |
AOM 130519 |
DiPER |
April 13, 2015 |
April 2018 |
May 2018 |
October 20, 2014 |
October 19, 2017 |
|
- Henri Mondor Hospital
Creteil, France
|
|
| 69 |
NCT02596555 |
Recruiting |
Low Molecular Weight Heparin for 72 Hours Followed by Dabigatran for Acute Intermediate-Risk Pulmonary Embolism. |
|
|
Interventional
|
Phase 4 |
- Prof. Stavros Konstantinides, MD
- European Georges Pompidou Hospital
- Johannes Gutenberg University Mainz
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Occurrence of symptomatic venous thromboembolism (VTE) or pulmonary embolism (PE) related death (yes/no)
- Recovery of right ventricle (RV) function
- Temporal pattern of changes in NT-proBNP (N-terminal prohormone of brain natriuretic peptide) levels
- (and 6 more...)
|
700 |
All |
18 Years and older (Adult, Older Adult) |
NCT02596555 |
PEITHO-2 |
PEITHO-2 |
January 2016 |
January 2019 |
August 2019 |
November 4, 2015 |
April 27, 2016 |
|
- Center for Thrombosis and Hemostasis, University Medical Center Mainz
Mainz, Germany
|
|
| 70 |
NCT00670540 |
Completed
Has Results |
Epidemiology of Thromboembolism Disease: A Cohort Study |
- Vascular Diseases
- Embolism and Thrombosis
- Phlebitis
- (and 2 more...)
|
- Other: procedure of Deep Vein Thrombosis (DVT) and PE (Pulmonary Embolism) diagnosis
|
Observational
|
|
- University Hospital, Grenoble
- Sanofi
- Ministry of Health, France
- SFMV (Société Française de Médecine Vasculaire)
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Percentage of Participants Who Developed a New or Recurrence of Venous Thromboembolism (VTE)
- Percentage of Participants Who Developed Major Bleeding Events
- Percentage of Participants With Treatment Anticoagulant Prescribed
- (and 4 more...)
|
8256 |
All |
18 Years and older (Adult, Older Adult) |
NCT00670540 |
DCIC-04-02 |
OPTIMEV |
November 2004 |
January 2009 |
February 2010 |
May 2, 2008 |
May 8, 2012 |
May 3, 2012 |
- University Hospital ND des Bruyeres Liege
Chenee, Belgium - General Hospital
Abbeville, France - Office-based Specialist in vascular medecine
Albertville, France - (and 228 more...)
|
|
| 71 |
NCT01174628 |
Unknown † |
Prospective Evaluation of Long-term Outcomes After Pulmonary Embolism |
|
|
Observational
|
|
- Sir Mortimer B. Davis - Jewish General Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Exercise Limitation
- Quality of Life
- Respiratory Disease-Specific Measures
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT01174628 |
MOP-93627 |
ELOPE |
June 2010 |
December 2014 |
February 2015 |
August 3, 2010 |
November 26, 2014 |
|
- QEII Health Sciences Centre
Halifax, Nova Scotia, Canada - The Ottawa Hospital
Ottawa, Ontario, Canada - Toronto General Hospital
Toronto, Ontario, Canada - (and 2 more...)
|
|
| 72 |
NCT00368836 |
Completed |
Breath Analysis Technique to Diagnose Pulmonary Embolism |
|
|
Interventional
|
Phase 2
Phase 3 |
- National Heart, Lung, and Blood Institute (NHLBI)
- WFD Ventures Incorporated
- National Heart, Lung, and Blood Institute (NHLBI)
|
NIH / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Evaluating the safety and effectiveness of the BreathScreen PE as an adjunct to the use of the D-dimer in evaluating patients clinically suspected of having pulmonary embolism
|
475 |
All |
18 Years and older (Adult, Older Adult) |
NCT00368836 |
433
R42HL086316-01 |
|
March 2006 |
April 2008 |
June 2008 |
August 29, 2006 |
September 30, 2008 |
|
- Carolinas Medical Center
Charlotte, North Carolina, United States
|
|
| 73 |
NCT00439777 |
Completed
Has Results |
Oral Direct Factor Xa Inhibitor Rivaroxaban in Patients With Acute Symptomatic Pulmonary Embolism - The EINSTEIN PE Study |
|
- Drug: Rivaroxaban (Xarelto, BAY59-7939)
- Drug: Enoxaparin overlapping with and followed by VKA
|
Interventional
|
Phase 3 |
- Bayer
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percentage of Participants With Symptomatic Recurrent Venous Thromboembolism [VTE] (i.e. the Composite of Recurrent Deep Vein Thrombosis [DVT] or Fatal or Non-fatal Pulmonary Embolism [PE]) Until the Intended End of Study Treatment
- Percentage of Participants With the Composite Variable Comprising Recurrent DVT, Non-fatal PE and All Cause Mortality Until the Intended End of Study Treatment
- Percentage of Participants With an Event for Net Clinical Benefit 1 Until the Intended End of Study Treatment
- (and 5 more...)
|
4833 |
All |
18 Years and older (Adult, Older Adult) |
NCT00439777 |
11702b
2006-004495-13 |
|
March 2007 |
September 2011 |
December 2011 |
February 26, 2007 |
February 27, 2014 |
January 24, 2013 |
- Little Rock, Arkansas, United States
- Redlands, California, United States
- Bay Pines, Florida, United States
- (and 302 more...)
|
|
| 74 |
NCT01106937 |
Unknown † |
Factor XIII and Pulmonary Embolism in Neurosurgical Patients |
- Brain Tumor
- Vascular Lesion
- Factor XIII Deficiency
- Pulmonary Embolism
|
|
Observational
|
|
- Ludwig-Maximilians - University of Munich
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of pulmonary embolisms following Factor XIII substitution
|
130 |
All |
Child, Adult, Older Adult |
NCT01106937 |
SG-1 |
|
October 2007 |
December 2010 |
December 2010 |
April 20, 2010 |
April 20, 2010 |
|
- Department of Neurosurgery, LMU
Munich, Bavaria, Germany
|
|
| 75 |
NCT01134068 |
Completed |
Age-adjusted D-dimer Cut-off Levels to Rule Out Pulmonary Embolism |
|
- Other: Evaluation of a modified DD cut-off to rule out PE
|
Interventional
|
Phase 4 |
- Marc Righini
- University Hospital, Brest
- University Hospital, Angers
- (and 2 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- The main outcome is the rate of thromboembolic events during a formal 3-month follow-up in patients not anticoagulated on the basis of a PE ruled out by the association mentioned here above.
- Prospective validation of the simplified revised Geneva score.
|
3306 |
All |
18 Years and older (Adult, Older Adult) |
NCT01134068 |
ADJUST |
ADJUST |
October 2010 |
July 2013 |
December 2013 |
May 31, 2010 |
May 28, 2015 |
|
- Angers University Hospital
Angers, France - Grégoire Le Gal
Brest, France - Amsterdam University hospital
Amsterdam, Netherlands - Geneva University Hospital
Geneva, Switzerland
|
|
| 76 |
NCT02733198 |
Unknown † |
Prognostication in Acute Pulmonary Embolism |
|
- Other: Prognosis-guided therapy
|
Interventional
|
Not Applicable |
- Ministry of Health, Spain
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02733198 |
PI15/00207 |
IPEP |
April 2016 |
April 2018 |
September 2018 |
April 11, 2016 |
January 30, 2017 |
|
- Hospital Ramon y Cajal, IRYCIS, Alcala de Henares University
Madrid, Spain
|
|
| 77 |
NCT00314002 |
Terminated |
Catheter Thrombectomy in Patients With Massive Pulmonary Embolism |
|
- Device: Mechanical Thrombectomy
|
Interventional
|
Phase 1
Phase 2 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Immediate decrease in mean pulmonary artery pressure
- Technical success
- Improved flow in the treated main and lobar pulmonary arteries
- In-hospital mortality will not exceed 20%
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT00314002 |
APE1 |
|
October 2005 |
|
April 2007 |
April 12, 2006 |
August 7, 2009 |
|
- Herz-Gefässklinik Bad Neustadt
Bad Neustadt, Germany - Klinik für Diagnostische Radiologie Christian-Albrechts-Universität Kiel
Kiel, Germany - Universität Leipzig Herzzentrum
Leipzig, Germany - (and 2 more...)
|
|
| 78 |
NCT02923115 |
Recruiting |
Randomized Study to Assess the Safety, Pharmacokinetics/Dynamics of DS-1040b in Subjects With Acute Submassive Pulmonary Embolism |
- Pulmonary Embolism
- Thrombotic Disease
|
- Drug: DS-1040b
- Drug: placebo
|
Interventional
|
Phase 1
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of participants with clinically relevant bleeding
- Change from baseline in pulmonary embolism PE thrombus volume
- Number of serious adverse events
- (and 7 more...)
|
137 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02923115 |
DS1040-B-U107
2015-005211-32 |
|
June 23, 2016 |
August 31, 2019 |
November 30, 2019 |
October 4, 2016 |
February 19, 2019 |
|
- Pulmonary Associates of Mobile
Mobile, Alabama, United States - Cedars-Sinai Medical Center
Beverly Hills, California, United States - University of California, San Diego (UCSD) Medical Center
San Diego, California, United States - (and 44 more...)
|
|
| 79 |
NCT02214043 |
Completed |
Clinical Characteristics of Acute Pulmonary Embolism in Chinese Population |
|
|
Observational
|
|
- Chinese Pulmonary Vascular Disease Research Group
- Chinese Pulmonary Vascular Disease Research Group
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The primary end point of the present study was symptomatic, objectively confirmed recurrent fatal or nonfatal VTE.
- The second end point was death (all cause death and PE-related death).
|
600 |
All |
15 Years to 85 Years (Child, Adult, Older Adult) |
NCT02214043 |
APEINCP |
|
January 2012 |
December 2017 |
December 2017 |
August 12, 2014 |
January 30, 2018 |
|
- Center of pumonary vascular diseases
Beijing, China
|
|
| 80 |
NCT01216423 |
Completed |
Pulmonary Embolism and Stroke in Patient With Patent Foramen Ovale |
- Recent Stroke
- Pulmonary Embolism
- Patent Foramen Ovale
|
|
Observational
|
|
- University Hospital, Brest
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of recent ischemic stroke in patients hospitalized for a recent pulmonary embolism with comparison in two groups with and without PFO
|
374 |
All |
18 Years and older (Adult, Older Adult) |
NCT01216423 |
EPIC-FOP |
EPIC-FOP |
November 2009 |
December 2015 |
January 2017 |
October 7, 2010 |
January 12, 2017 |
|
- Brest University Hospital
Brest, France - Army Hospital
Brest, France - CHU Dijon de Bocage
Dijon, France - Centre Hospitalier de Cornouaille
Quimper, France
|
|
| 81 |
NCT00442234 |
Completed |
Post-marketing Study of Monteplase ("Cleactor") in Patients With Acute Pulmonary Embolism |
|
|
Interventional
|
Phase 4 |
- Eisai Inc.
- Eisai Co., Ltd.
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Monteplase antigen levels in plasma; Monteplase activity in plasma; parameters of coagulating and fibrinolytic system (Plasminogen activity, a2-PI, PIC, fibrinogen, D-dimer).
- Symptoms and signs of acute pulmonary embolism; pulmonary thrombosis; echocardiography; pulmonary arterial pressure; blood gas; vital signs; laboratory tests (e.g., hematology and blood chemistry); adverse events; concomitant therapies; dosing regimen.
|
5 |
All |
20 Years to 75 Years (Adult, Older Adult) |
NCT00442234 |
E6010-J081-591 |
|
May 1, 2007 |
April 1, 2008 |
April 1, 2008 |
March 1, 2007 |
October 18, 2018 |
|
- Yokohama, Kanagawa, Japan
- Bunkyo-ku, Tokyo, Japan
|
|
| 82 |
NCT01486511 |
Unknown † |
Pulmonary Embolism After Liver Resection |
- Liver Disease
- Pulmonary Embolism
- Thrombophilia
- Death
|
- Procedure: Liver resection
- Radiation: Computed Tomography
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Pulmonary embolism
- Complications
- Length of hospital stay
- Mortality
|
500 |
All |
18 Years and older (Adult, Older Adult) |
NCT01486511 |
Beaujon |
|
January 2007 |
January 2012 |
January 2012 |
December 6, 2011 |
December 6, 2011 |
|
- Prof. Jacques Belghiti
Paris, Clichy, France
|
|
| 83 |
NCT00117169 |
Completed |
Multi-Detector Spiral Computed Tomography Alone Versus Combined Strategy With Lower Limb Compression Ultrasonography in Outpatients Suspected of Pulmonary Embolism |
|
- Procedure: multi-detector helical computed tomography
|
Interventional
|
Not Applicable |
- University Hospital, Geneva
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
|
- The primary outcome variable will be the number of thromboembolic events in the 3-month follow-up period in each group.
- Costs incurred in each study arm. (Costs will be directly measured and will represent direct costs, not charges. Measurements will include all costs due to diagnosis of PE, including the costs associated with the length of stay in the emergency ward)
- Classification performances of the revised Geneva standardised clinical score, as assessed by its capacity to distinguish patients having low, intermediate and high probability of PE
- (and 2 more...)
|
1500 |
All |
18 Years and older (Adult, Older Adult) |
NCT00117169 |
CT-EP4
FNRS, Grant No 3200B0-105988 |
|
January 2005 |
|
October 2006 |
July 4, 2005 |
October 15, 2012 |
|
- Geneva University Hospital
Geneva, Switzerland
|
|
| 84 |
NCT03375723 |
Recruiting |
Effects of Information and Breathing Technique - for Patients With Respiratory Pain in Acute Pulmonary Embolism. |
|
- Other: Information on anatomy and physiology, and breathing technique
- Other: Usual care treatment
|
Interventional
|
Not Applicable |
- Göteborg University
- The Renée Eander Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Respiratory associated pain estimated with Visual Analogue Scale (VAS).
- Analgesic consumption
- Frequency use of breathing technique.
- (and 3 more...)
|
160 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03375723 |
FoU in VGR 235991 |
|
October 1, 2018 |
December 31, 2020 |
January 14, 2021 |
December 18, 2017 |
November 6, 2018 |
|
- Sahlgrenska University Hospital
Göteborg, Västra Götaland, Sweden
|
|
| 85 |
NCT00680628 |
Terminated
Has Results |
Clot Dissolving Treatment for Blood Clots in the Lungs |
|
- Drug: Tenecteplase + Enoxaparin
- Drug: 0.9% Saline + Enoxaparin
|
Interventional
|
Phase 3 |
- Jeffrey Kline
- Carolinas Healthcare System
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of Patients With Cardiogenic Shock or Respiratory Failure From Pulmonary Embolism and Number of Patietnts With Major Hemorrhage
- Number With Functional Cardiopulmonary Limitations Assessed With a Composite Measurement (Six Minute Walk Distance, Right Ventricular Function and Quality of Life Score on the SF-36)
- Number With Recurrent Venous Thromboembolism and/or Severe Post-phlebitic Syndrome
|
83 |
All |
18 Years and older (Adult, Older Adult) |
NCT00680628 |
01-08-01A |
|
May 2008 |
May 2012 |
October 2012 |
May 20, 2008 |
August 11, 2014 |
August 11, 2014 |
- University of California, Davis Medical Center
Sacramento, California, United States - University of Colorado Hospital
Aurora, Colorado, United States - Northwestern Memorial Hospital
Chicago, Illinois, United States - (and 4 more...)
|
|
| 86 |
NCT02601846 |
Recruiting |
Age-adjusted D-dimer Cut-off to Rule Out Pulmonary Embolism in the Emergency Department : A Real Life Impact Study |
|
|
Observational
|
|
- University Hospital, Geneva
- University Hospital, Brest
- The Ottawa Hospital
- (and 4 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The incidence of symptomatic thromboembolic events (objectively confirmed pulmonary embolism and/or deep vein thrombosis) during follow-up in patients with D-dimer levels below age-adjusted cutoff
- Proportion of patients with a non-high clinical probability and a D-dimer result between 500µg/L and their age-adjusted cut-off value
|
1100 |
All |
18 Years and older (Adult, Older Adult) |
NCT02601846 |
Geneva 15-010 |
RELAX-PE |
November 2015 |
December 2018 |
March 2019 |
November 10, 2015 |
November 14, 2018 |
|
- Cliniques Universitaires Saint-Luc
Brussels, Belgium - CHU de Liège
Liege, Belgium - Albert Trinh-Duc
Agen, France - (and 8 more...)
|
|
| 87 |
NCT02979561 |
Unknown † |
Pradaxa or Warfarin for Prevention of Recurrent VTE in Patients With Angiographically Confirmed Acute Massive Pulmonary Embolism undergoIng Endovascular Mechanical Fragmentation and Thrombolytic Therapy |
- Angiographically Confirmed Acute Massive Pulmonary Embolism Treated With Endovascular Mechanical Fragmentation and Thrombolytic Therapy
|
- Drug: Dabigatran Etexilate
- Drug: Warfarin
|
Interventional
|
Phase 4 |
- Meshalkin Research Institute of Pathology of Circulation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- recurrent PE
- death
- hemorrhagic complications
- (and 2 more...)
|
200 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02979561 |
RE-SPIRE study |
Re-Spire |
October 2016 |
June 2018 |
June 2018 |
December 1, 2016 |
December 20, 2016 |
|
- Federal State Institution Academician E.N.Meshalkin Novosibirsk State Research Institute Of Circulation Pathology Rusmedtechnology
Novosibirsk, Russian Federation
|
|
| 88 |
NCT03389971 |
Recruiting |
ULTRAsound-assisted Catheter vs. STAndaRd Catheter Thrombolysis for Submassive Pulmonary Embolism |
- Submassive Pulmonary Embolism
|
- Procedure: catheter-directed thrombolysis
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- thrombus load reduction
- cardiopulmonary and clinical outcomes - echocardiographic
- cardiopulmonary and clinical outcomes - hemodynamic
- (and 10 more...)
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03389971 |
UltraStar sPE |
UltraStar sPE |
December 6, 2017 |
February 1, 2020 |
February 1, 2020 |
January 4, 2018 |
January 5, 2018 |
|
- Piedmont Healthcare
Atlanta, Georgia, United States
|
|
| 89 |
NCT02843243 |
Unknown † |
Validation of Different Risk Assessment Strategies in Normotensive Pulmonary Embolism |
|
|
Observational
|
|
- Azienda Ospedaliera Cosenza
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adverse events PE-related
|
500 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT02843243 |
bova 1 protocol |
|
December 2016 |
December 2017 |
March 2018 |
July 25, 2016 |
January 24, 2017 |
|
- Azienda ospedaliera Cosenza
Cosenza, Italy
|
|
| 90 |
NCT03218410 |
Recruiting |
Surgical Pulmonary Embolectomy Versus Catheter-directed Thrombolysis in the Treatment of Pulmonary Embolism: A Non-inferiority Study |
- Acute Pulmonary Embolism (PE)
|
- Procedure: surgical pulmonary embolectomy
- Combination Product: catheter-directed thrombolysis
|
Interventional
|
Not Applicable |
- University Hospital Inselspital, Berne
- University of Bern
- Schweizerische Herzstiftung
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Difference in RV/LV ratio by contrast-enhanced chest computed tomography
- Difference in pulmonary occlusion score by contrast-enhanced chest computed tomography
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03218410 |
183/15 |
Lungembolism |
October 1, 2015 |
June 30, 2020 |
December 2020 |
July 14, 2017 |
January 16, 2019 |
|
- University Hospital Bern
Bern, Switzerland
|
|
| 91 |
NCT00062803 |
Completed |
SR34006 Compared to Vitamin K Antagonist (VKA) in the Treatment of Pulmonary Embolism |
|
- Drug: SR34006
- Drug: (LMW)heparin
- Drug: Warfarin VKA
- Drug: Acenocoumarol VKA
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- symptomatic recurrent pulmonary embolism or deep vein thrombosis within 3 months.
- symptomatic recurrent PE/DVT within 6 months.
|
|
All |
18 Years and older (Adult, Older Adult) |
NCT00062803 |
EFC3484 |
|
June 2003 |
October 2005 |
October 2005 |
June 17, 2003 |
April 29, 2009 |
|
- Jerry L. Pettic VA Medical Center
Loma Linda, California, United States - University of California, San Diego Medical Center
San Diego, California, United States - Anschutz Cancer Pavilion
Aurora, Colorado, United States - (and 90 more...)
|
|
| 92 |
NCT03366519 |
Recruiting |
Clinical Echography in Emergency Prognostic Evaluation of Pulmonary Embolism: ECU -EP Study. |
|
- Procedure: clinical echography (CE)
|
Observational
|
|
- Centre Hospitalier Universitaire de Saint Etienne
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Patients with a measure RV/LV ratio ≥ 0.9 on clinical echography (CE) and CT Scan
- Patients with a measure RV/LV ratio < 0.9 on clinical echography (CE) and CT Scan
- Patients with abnormal inferior vena cava.
- death
|
210 |
All |
18 Years and older (Adult, Older Adult) |
NCT03366519 |
1608163
2016-A01721-50 |
ECU-EP |
November 2018 |
December 2018 |
January 2019 |
December 8, 2017 |
October 22, 2018 |
|
- Hôpital le Corbusier à Firminy
Firminy, France - CH du Forez
Montbrison, France - CH Roanne
Roanne, France - Chu Saint-Etienne
Saint Etienne, France
|
|
| 93 |
NCT01166997 |
Completed
Has Results |
ULTrasound Accelerated ThrombolysIs of PulMonAry Embolism |
- Submassive Pulmonary Embolism
|
- Device: EkoSonic Endovascular System
- Drug: Unfractionated heparin
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction of RV/LV Ratio
- Major Bleeding and Intracranial Bleeding at 30 Days.
|
59 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01166997 |
EKOS Protocol Number 08 |
ULTIMA |
July 2010 |
April 2013 |
May 2013 |
July 21, 2010 |
October 18, 2016 |
October 18, 2016 |
- Klinikum Lippe-Detmold
Detmold, Germany - Klinikum Dortmund gGmbH
Dortmund, Germany - Universitätsklinikum Carl Gustav Carus an der TU Dresden
Dresden, Germany - (and 7 more...)
|
|
| 94 |
NCT02360943 |
Recruiting |
Pharmacoepidemiology Treatment of Symptomatic Pulmonary Embolism in Hospitalized Patients Aged 75 Years or More: PEAGE |
- Elderly
- Pulmonary Embolism
- Anticoagulants
|
|
Observational
|
|
- Centre Hospitalier Universitaire de Saint Etienne
- Ministry of Health, France
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Major bleeding defined by the International Society of Thrombosis & Haemostasis
- Clinically relevant non-major bleeding
- Recurrent pulmonary embolism
- (and 3 more...)
|
1500 |
All |
75 Years and older (Older Adult) |
NCT02360943 |
1208182
2013-000315-24 |
PEAGE |
July 9, 2014 |
December 2019 |
June 2020 |
February 11, 2015 |
November 20, 2018 |
|
- CHU d'Angers
Angers, France - Hôpital Universitaire Jean Minjoz
Besancon, France - CHU de Brest
Brest, France - (and 17 more...)
|
|
| 95 |
NCT00214929 |
Unknown † |
Home Treatment of Pulmonary Embolism |
|
- Behavioral: treatment at home
|
Interventional
|
Phase 4 |
- Carlos III Health Institute
- Spanish Society of Pneumology and Thoracic Surgery
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- -Thromboembolic recurrences
- -Bleeding Complications
- -Deaths
- -Quality of life
|
|
All |
18 Years and older (Adult, Older Adult) |
NCT00214929 |
PIO30192 |
|
December 2004 |
|
August 2005 |
September 22, 2005 |
December 9, 2005 |
|
- Pneumology Service of HVR
Seville, Spain
|
|
| 96 |
NCT00381511 |
Completed |
Deferment of Imaging for Pulmonary Embolism |
|
- Drug: low molecular weight heparin
|
Interventional
|
Phase 4 |
- Azienda Ospedaliera Universitaria Policlinico
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Recurrent venous thromboembolism
- major bleeding
- death
|
300 |
All |
18 Years and older (Adult, Older Adult) |
NCT00381511 |
3090A-101657 |
|
January 1999 |
|
April 2004 |
September 28, 2006 |
October 17, 2006 |
|
|
|
| 97 |
NCT00241826 |
Completed |
Prospective Investigation of Pulmonary Embolism Diagnosis III |
- Lung Diseases
- Pulmonary Embolism
|
- Procedure: Magnetic Resonance Angiography
- Procedure: Magnetic Resonance Venography
|
Observational
|
|
- George Washington University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diagnosis or exclusion of pulmonary embolism in agreement with a reference standard
|
1256 |
All |
18 Years and older (Adult, Older Adult) |
NCT00241826 |
329
U01HL077155
U01HL077149
U01HL077150
U01HL077151
U01HL077153
U01HL077154
U01HL077358
U01HL081593
U01HL081594 |
|
April 2006 |
September 2008 |
April 2009 |
October 19, 2005 |
August 20, 2013 |
|
- Emory University
Atlanta, Georgia, United States - Divison of Lung Diseases, NHLBI
Bethesda, Maryland, United States - Data Coordinating Center
Rockville, Maryland, United States - (and 6 more...)
|
|
| 98 |
NCT01183026 |
Completed |
V/Q SPECT for Diagnosis of Pulmonary Embolism |
|
|
Observational
|
|
- University Hospital, Brest
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
300 |
All |
18 Years and older (Adult, Older Adult) |
NCT01183026 |
SPECT |
|
January 2004 |
|
December 2006 |
August 17, 2010 |
August 17, 2010 |
|
|
|
| 99 |
NCT01797289 |
Completed |
Prevalence of Pulmonary Embolism in Patients With Syncope |
- Syncope
- Pulmonary Embolism
|
- Other: Lung CT or V/Q scanning in patients with a high pre-test clinical probability of PE and/or a positive D-dimer
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- To assess the prevalence of PE in a large series of consecutive patients presenting with the first episode of syncope
- To assess the prevalence of pulmonary embolism in patients with apparently unexplained syncope
|
600 |
All |
18 Years and older (Adult, Older Adult) |
NCT01797289 |
52823P |
PESY |
February 2012 |
October 2014 |
October 2014 |
February 22, 2013 |
January 26, 2015 |
|
- Clinica Medica 2 University of Padua
Padua, Italy
|
|
| 100 |
NCT02375919 |
Completed |
PERC Rule to Exclude Pulmonary Embolism in the Emergency Deparment |
|
- Other: PERC based Strategy
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Failure percentage of the diagnostic strategy (diagnosed deep venous thrombosis or pulmonary embolism) at 3 month follow up
- Rate of Computed Tomography Pulmonary Angiogram (CTPA) and related adverse event
- Length of stay in the Emergency Department
- (and 4 more...)
|
1922 |
All |
18 Years and older (Adult, Older Adult) |
NCT02375919 |
IDRCB 2015-A00215-44
P1409 |
PROPER |
August 2015 |
April 2017 |
April 2017 |
March 3, 2015 |
July 25, 2017 |
|
- Hospital Pitié-Salpêtrière
Paris, France
|
|
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