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215 studies found for:    prodrugs
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Rank Status Study
1 Withdrawn Efficacy Study of Aminoflavone Prodrug to Treat Breast Cancer
Condition: Breast Neoplasm
Intervention: Drug: Aminoflavone Prodrug
2 Completed Bioavailability Study of Prodrug of GLPG0187 in Healthy Volunteers
Condition: Healthy
Intervention: Drug: GLPG0187 prodrug
3 Completed Study to Evaluate the Pharmacokinetics of 14C-labeled Isavuconazole Following a Single Oral Dose of 14C-labeled Prodrug Isavuconazonium Sulfate (BAL8557) in Healthy Male Subjects
Conditions: Pharmacokinetics of 14C-labeled Isavuconazole;   Healthy Subjects
Intervention: Drug: 14C-labeled prodrug isavuconazonium sulfate
4 Not yet recruiting A Study of the Relative Bioavailability of BMS-626529 Administered as BMS-663068 (Prodrug) From 150mg Low-dose Extended-release Tablets Compared to 600mg Reference Extended-release Tablets in Healthy Subjects
Condition: HIV (Human Immuno-Deficiency Virus)
Interventions: Drug: BMS-663068 (1 tablet at 600 mg);   Drug: BMS-663068 (4 tablets at 150 mg each tablet)
5 Completed Safety and Effectiveness of Adding PMPA Prodrug to an Anti-HIV Drug Combination to Treat HIV-Infected Patients
Condition: HIV Infections
Intervention: Drug: Tenofovir disoproxil fumarate
6 Active, not recruiting A Phase I Study of AdV-tk + Prodrug Therapy in Combination With Radiation Therapy for Pediatric Brain Tumors
Conditions: Malignant Glioma;   Recurrent Ependymoma
Interventions: Biological: AdV-tk;   Drug: valacyclovir;   Radiation: Radiation
7 Completed A Study of BCI-838 and Several BCI-632 Prodrugs in Healthy Volunteers
Condition: Healthy
Interventions: Drug: BCI-838;   Drug: BCI-1038, BCI-1206 & BCI-1283
8 Recruiting Genetic Determinants of ACEI Prodrug Activation
Condition: Healthy Volunteers
Intervention: Drug: Enalapril
9 Recruiting Intravenously Administered Pegylated Liposomal Mitomycin-C Lipid-based Prodrug (PROMITIL) in Cancer Patients With Solid Tumors.
Conditions: Cancer;   Solid Tumor;   Metastatic Colorectal Cancer (mCRC)
Interventions: Drug: Promitil;   Drug: Capecitabine
10 Unknown  The Safety and Effectiveness of PMPA Prodrug in HIV-Infected Patients
Condition: HIV Infections
Intervention: Drug: Tenofovir disoproxil fumarate
11 Completed A Study of Hepatitis C Virus (HCV) Polymerase Inhibitor Pro-Drug in Combination With PEGASYS Plus COPEGUS Compared With PEGASYS Plus COPEGUS in Patients With Chronic Hepatitis C Genotype 1 Infection.
Condition: Hepatitis C, Chronic
Interventions: Drug: Copegus;   Drug: Pegasys;   Drug: RO4588161
12 Completed A Study of Hepatitis C Virus (HCV) Polymerase Inhibitor Pro-Drug in Combination With PEGASYS With or Without COPEGUS in Patients With Chronic Hepatitis C (CHC) Genotype 1 Infection.
Condition: Hepatitis C, Chronic
Interventions: Drug: Copegus;   Drug: PEGASYS;   Drug: RO5024048 1500mg;   Drug: RO5024048 3000mg
13 Suspended Sorafenib Tosylate and Hypoxia-Activated Prodrug TH-302 in Treating Patients With Advanced Kidney Cancer or Liver Cancer That Cannot Be Removed By Surgery
Conditions: Kidney Cancer;   Liver Cancer
Interventions: Drug: hypoxia-activated prodrug TH-302;   Drug: sorafenib tosylate
14 Completed Study of Hypoxia-Activated Prodrug TH-302 to Treat Advanced Leukemias
Conditions: Acute Myelogenous Leukemia;   Acute Lymphoblastic Leukemia;   Chronic Myelogenous Leukemia;   High-risk Myelodysplastic Syndrome;   Chronic Lymphocytic Leukemia;   Advanced Myelofibrosis
Intervention: Drug: TH-302
15 Completed A Study on the Effect of Renal Function on the Pharmacakokinetics of RO5024048 (Parent of Prodrug RO5024048) Following Multiple Oral Dose Administration of RO5024048
Condition: Healthy Volunteer
Intervention: Drug: RO5024048
16 Completed Bioavailability of BIBR 953 ZW After BIBR 1048 (Oral Pro-drug of BIBR 953 ZW) Administered as Hydroxypropyl Methylcellulose (HPMC) Polymorph II Capsule Relative to HPMC Polymorph I Capsule in Healthy Subjects.
Condition: Healthy
Interventions: Drug: BIBR 1048 MS polymorph II;   Drug: BIBR 1048 MS polymorph I
17 Completed A Study of the Pharmacokinetics and Safety of BMS-663068 Administered in Subjects With Normal Renal Function and With Mild, Moderate, Severe and End Stage Renal Dysfunction
Condition: Infection, Human Immunodeficiency Virus
Intervention: Drug: Oral BMS-663068 (pro-drug)
18 Unknown  A Phase I Gene Therapy Study of FP253/Fludarabine for Prostate Cancer
Condition: Prostate Cancer
Intervention: Biological: Gene Directed Enzyme Prodrug Therapy, FP253/Fludarabine
19 Completed Safety Study to Evaluate BMS-830216 in Healthy Subjects
Condition: Obesity
Interventions: Drug: BMS-830216;   Drug: Placebo
20 Completed
Has Results
A Relative Bioavailability Study of Valcyte (Valganciclovir) in Lung Transplant Recipients With or Without Cystic Fibrosis.
Condition: Cytomegalovirus Infections
Intervention: Drug: valganciclovir [Valcyte]

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Study has passed its completion date and status has not been verified in more than two years.