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49 studies found for:    phenylbutyrate
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Rank Status Study
1 Active, not recruiting Phenylbutyrate Therapy for Maple Syrup Urine Disease
Condition: Maple Syrup Urine Disease
Interventions: Drug: Phenylbutyrate;   Drug: Placebo powder
2 Withdrawn Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3
Condition: Spinocerebellar Ataxia Type 3
Interventions: Drug: Placebo;   Drug: Sodium Phenylbutyrate
3 Completed Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders
Condition: UCDs (The Data May be Helpful in the Treatment of UCDs.)
Interventions: Drug: Sodium Benzoate;   Drug: Sodium Phenylbutyrate;   Drug: Phenylbutyrate and Benzoate
4 Completed Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: sodium phenylbutyrate
5 Active, not recruiting Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
Condition: Parkinson's Disease
Intervention: Drug: Glycerol Phenylbutyrate
6 Completed
Has Results
Dose-Escalation Safety Study of HPN-100 to Treat Urea Cycle Disorders
Condition: Urea Cycle Disorders
Interventions: Drug: HPN-100;   Drug: BUPHENYL®
7 Completed
Has Results
Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy
Condition: Spinal Muscular Atrophy
Intervention: Drug: Sodium phenylbutyrate (NaPB)
8 Completed Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)
Condition: Huntington's Disease
Intervention: Drug: sodium phenylbutyrate
9 Terminated Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Conditions: Mucinous Adenocarcinoma of the Colon;   Mucinous Adenocarcinoma of the Rectum;   Recurrent Colon Cancer;   Recurrent Rectal Cancer;   Signet Ring Adenocarcinoma of the Colon;   Signet Ring Adenocarcinoma of the Rectum;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
Interventions: Drug: fluorouracil;   Drug: sodium phenylbutyrate;   Drug: indomethacin;   Biological: recombinant interferon gamma
10 Completed
Has Results
Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder
Conditions: Argininosuccinic Aciduria;   Amino Acid Metabolism, Inborn Errors;   Urea Cycle Disorders
Interventions: Drug: Sodium Phenylbutyrate;   Drug: Arginine
11 Completed Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors
Condition: Brain Tumor
Intervention: Drug: Phenylbutyrate
12 Completed Phenylbutyrate in Treating Patients With Refractory Solid Tumors or Lymphoma
Conditions: Lymphoma;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: chemotherapy;   Drug: oral sodium phenylbutyrate
13 Terminated
Has Results
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
Condition: Spinal Muscular Atrophy Type I
Intervention: Drug: sodium phenylbutyrate
14 Terminated
Has Results
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
Conditions: Spinal Muscular Atrophy Type II;   Spinal Muscular Atrophy Type III
Intervention: Drug: sodium phenylbutyrate
15 Completed
Has Results
Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders
Condition: Urea Cycle Disorders
Interventions: Drug: HPN-100;   Drug: NaPBA
16 Completed Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Condition: Pulmonary Tuberculosis
Interventions: Drug: Active Sodium Phenylbutyrate and active cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus active cholecalciferol;   Drug: Active Sodium Phenylbutyrate and placebo cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
17 Terminated
Has Results
Phenylbutyrate/Genistein Duotherapy in Delta F508-Heterozygotes (for Cystic Fibrosis)
Condition: Cystic Fibrosis
Interventions: Drug: Sodium 4-Phenylbutyrate;   Drug: Genistein (Unconjugated Isoflavones 100);   Drug: Placebo
18 Completed Phase I and Pharmacokinetic Trial of Phenylbutyrate Given as a Continuous Infusion in Pediatric Patients With Refractory Malignancy
Conditions: Brain Neoplasms;   Neuroblastoma
Intervention: Drug: phenylbutyrate
19 Completed Phenylbutyrate/Genistein Duotherapy in Delta F508-Homozygous(for Cystic Fibrosis)
Condition: Cystic Fibrosis
Interventions: Drug: Sodium 4-Phenylbutyrate (4PBA);   Drug: Unconjugated Isoflavones 100 (PTI G-4660, 87% Genistein);   Drug: Placebo
20 Completed Immune Reconstitution in Tuberculosis Disease
Condition: Pulmonary Tuberculosis (TB)
Interventions: Drug: vitamin D (cholecalciferol) and PBA (sodium phenylbutyrate);   Drug: Placebo tablets

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Study has passed its completion date and status has not been verified in more than two years.