| 1 |
NCT03212703 |
Recruiting |
Mindfulness for Parents of OCD-affected Children |
- Obsessive-Compulsive Disorder
|
- Behavioral: Mindfulness-Based Skills Training (MBST)
- Other: Waitlist control (WLC)
|
Interventional
|
Not Applicable |
- University of British Columbia
- Michael Smith Foundation for Health Research
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in parental stress levels compared to waiting list control (WLC).
- Change in ability to tolerate OCD-related distress compared to waiting list control (WLC).
- Change in ability to resist family accommodation of the child's OCD symptoms compared to waiting list control (WLC).
- (and 3 more...)
|
45 |
All |
18 Years and older (Adult, Older Adult) |
NCT03212703 |
H14-02099 |
MBST |
July 2015 |
September 2019 |
October 2019 |
July 11, 2017 |
October 11, 2018 |
|
- BC Children's Hospital Research Institute
Vancouver, British Columbia, Canada
|
|
| 2 |
NCT02884674 |
Recruiting |
Repetitive Transcranial Magnetic Stimulation in Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Device: Active Repetitive Transcranial Magnetic Stimulation
- Device: Placebo Repetitive Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline of the score at the Yale - Brown Obsessive and Compulsive Scale
- Score of Montgomery and Asberg Depression Rating Scale, as a Measure of effects on Mood (depression)
- Score of Young Mania Rating Scale, as a Measure of effects on Mood (hyperthymia)
- (and 9 more...)
|
56 |
All |
18 Years and older (Adult, Older Adult) |
NCT02884674 |
38RC14.156
2014-A00668-39 |
MAGTOC |
May 2015 |
November 2017 |
May 2020 |
August 31, 2016 |
May 15, 2018 |
|
- CHU de Grenoble - Pavillon Dominique Villars
Grenoble, Rhone Alpes, France
|
|
| 3 |
NCT01343732 |
Recruiting |
Tolerability, Safety and Efficacy of the HAC-Coil Deep Transcranial Magnetic Stimulation in Medication Resistance Obsessive Compulsive Disorder (OCD) Subjects |
- Obsessive Compulsive Disorder
|
|
Interventional
|
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Y-BOCS Scale (Yale-Brown Obsessive Compulsive Disorder)
|
40 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01343732 |
OCD-DTMS-1 |
|
June 2011 |
November 2018 |
November 2018 |
April 28, 2011 |
January 25, 2018 |
|
- Sheba Medical Center
Ramat Gan, Israel
|
|
| 4 |
NCT03172728 |
Not yet recruiting |
Psycho-education Intervention for Postpartum OCD and it's Influence on Symptom Severity and Treatment Self Referral Rates |
- Obsessive-Compulsive Disorder
|
- Behavioral: psycho-education pamphlet
|
Interventional
|
Not Applicable |
- Tel-Aviv Sourasky Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Obsessive Compulsive Inventory-Revised questionnaire
|
100 |
Female |
18 Years to 45 Years (Adult) |
NCT03172728 |
TASMC-16-GA-0658-CTIL |
|
June 2017 |
June 2019 |
June 2020 |
June 1, 2017 |
June 1, 2017 |
|
|
|
| 5 |
NCT02739061 |
Recruiting |
The Study of the Pathogenesis and Cognitive Behavioral Group Therapy in Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Behavioral: cognitive behavioral group therapy
- Drug: sertraline, fluvoxamine
- Other: cognitive behavioral group therapy and drug therapy
|
Interventional
|
Not Applicable |
- Shanghai Mental Health Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Y-BOCS (The Yale-Brown Obsessive Compulsive Scale)
|
240 |
All |
18 Years to 54 Years (Adult) |
NCT02739061 |
HYZhang |
|
April 2016 |
July 2017 |
July 2017 |
April 14, 2016 |
May 5, 2017 |
|
- Clinical psychiatrist
Shanghai, Shanghai, China
|
|
| 6 |
NCT02850393 |
Not yet recruiting |
Inhibitory Control of the Mind : Neural Bases and Impact for Obsessive-compulsive Disorders |
- Obsessive Compulsive Disorder
- Healthy
|
- Other: Functional magnetic resonance imaging
- Behavioral: behavioral measures
- Other: physiological measurements
|
Interventional
|
Not Applicable |
- University Hospital, Caen
- Institut National de la Santé Et de la Recherche Médicale, France
- Centre National de la Recherche Scientifique, France
- Université de Caen Normandie
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Blood Oxigen Level Dependent (BOLD) response as measured with fMRI
|
48 |
All |
18 Years to 55 Years (Adult) |
NCT02850393 |
2015-A01609-40
160028B-31 |
SUPTOC |
July 2016 |
March 2019 |
December 2019 |
August 1, 2016 |
August 1, 2016 |
|
- GIP Cyceron
Caen, Calvados, France
|
|
| 7 |
NCT02704117 |
Recruiting |
Neurocircuitry of Obsessive-Compulsive Disorder: Modulation by Transcranial Direct Current Stimulation |
- Obsessive-Compulsive Disorder
|
- Device: Transcranial direct current stimulation (tDCS)
|
Interventional
|
Phase 1 |
- Butler Hospital
- University of Rochester
- Harvard University
- (and 2 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in activation of pre-supplementary motor area/dorsal anterior cingulate cortex (pSMA/dACC) on functional magnetic resonance imaging (fMRI) during the Multi-Source Interference task (MSIT)
- Change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02704117 |
P50MH106435 |
|
June 2015 |
May 2020 |
May 2020 |
March 9, 2016 |
January 4, 2018 |
|
- Butler Hospital
Providence, Rhode Island, United States
|
|
| 8 |
NCT02206945 |
Recruiting |
Neurofeedback for Obsessive-Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
- Behavioral: neurofeedback
- Behavioral: control feedback
|
Interventional
|
Not Applicable |
- Yale University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- A modified version of the Yale-Brown Obsessive-Compulsive Symptom scale (Y-BOCS) will be used, that queries subjects regarding symptoms
- Control over target brain area
- Control over the target brain area.
|
54 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02206945 |
0206017435-2
R01MH100068 |
|
July 2015 |
May 2019 |
July 2019 |
August 1, 2014 |
February 6, 2018 |
|
- Yale University School of Medicine
New Haven, Connecticut, United States
|
|
| 9 |
NCT03511534 |
Recruiting |
Open/Aftercare Treatment for Participants Diagnosed With Obsessive Compulsive Disorder |
|
- Behavioral: Psychotherapy
- Other: Pharmacotherapy
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT03511534 |
41165 |
|
June 23, 2017 |
June 2025 |
June 2026 |
April 30, 2018 |
May 1, 2018 |
|
- Stanford University
Stanford, California, United States
|
|
| 10 |
NCT03667807 |
Not yet recruiting |
TMS-induced Plasticity Improving Cognitive Control in OCD |
- Obsessive-Compulsive Disorder
|
- Device: Repetitive transcranial magnetic stimulation
|
Interventional
|
Not Applicable |
- VU University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- task based functional magnetic resonance imaging (fMRI) blood oxygen level dependent (BOLD) response
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
|
75 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03667807 |
91717306 |
TIPICCO |
November 2018 |
January 2022 |
November 2022 |
September 12, 2018 |
September 12, 2018 |
|
|
|
| 11 |
NCT03241056 |
Recruiting |
Cognitive Checking Intervention for Maladaptive Beliefs About Memory |
- Obsessive-Compulsive Disorder
|
- Behavioral: CBT for Maladaptive Beliefs about Memory
- Other: Treatment as Usual
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Vancouver Obsessional Compulsive Inventory - checking subscale (change)
- Average time spent checking per week (change)
- Vancouver Obsessional Compulsive Inventory - checking subscale
- (and 4 more...)
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT03241056 |
H2017:142 |
|
January 4, 2018 |
September 2019 |
September 2019 |
August 7, 2017 |
September 7, 2018 |
|
- St. Boniface Hospital
Winnipeg, Manitoba, Canada
|
|
| 12 |
NCT03313622 |
Not yet recruiting |
Locating Biomarkers in OCD Through Behavioral Tasks |
- OCD
- Obsessive-Compulsive Disorder
|
- Behavioral: Beads Task
- Behavioral: PROVOC Tasks
|
Observational
|
|
- Baylor College of Medicine
- Brown University
- University of Pittsburgh
- Butler Hospital
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - Beads task
- Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - PROVOC Task 1
- Investigate for biomarkers of obsessive compulsive disorder pathophysiology through the use of behavioral tasks - PROVOC Task 2
- (and 4 more...)
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03313622 |
H42237 |
|
November 2019 |
March 2020 |
March 2020 |
October 18, 2017 |
January 15, 2019 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States - Brown University
Providence, Rhode Island, United States - Baylor College of Medicine
Houston, Texas, United States
|
|
| 13 |
NCT02500888 |
Recruiting |
Evaluation of Capsulotomy by Linear Accelerator Radiosurgery in Severe and Refractory Obsessive-compulsive Disorder |
|
|
Interventional
|
Not Applicable |
- Hospital de Clinicas de Porto Alegre
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in OCD symptoms
- Change in quality of life.
- Change in brain-derived neurotrophic factor (BDNF) blood dosing
- (and 7 more...)
|
10 |
All |
18 Years to 55 Years (Adult) |
NCT02500888 |
14-0341 |
|
June 30, 2015 |
June 30, 2019 |
June 30, 2019 |
July 17, 2015 |
March 13, 2018 |
|
- Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande Do Sul, Brazil
|
|
| 14 |
NCT02433886 |
Recruiting |
Efficacy and Adverse Events of Bilateral Single-shot VC/VS Gamma Capsulotomy for OCD: a Pilot Study |
- Obsessive-compulsive Disorder
|
- Procedure: Gamma Ventral Capsulotomy
|
Interventional
|
Phase 2 |
- University of Sao Paulo General Hospital
- Hospital do Coracao
- Brown University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
|
5 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02433886 |
GammaOCD_IPq_HCor |
|
December 2014 |
December 2018 |
December 2020 |
May 5, 2015 |
May 5, 2015 |
|
- OCD Clinics (PROTOC), Department of Psychiatry, University of Sao Paulo General Hospital
Sao Paulo, SP, Brazil
|
|
| 15 |
NCT03677947 |
Recruiting |
Inference-Based Cognitive Therapy Versus Exposure and Response Prevention for Obsessive-Compulsive Disorder |
- Obsessive-compulsive Disorders and Symptoms
- Obsessive-Compulsive Disorder
|
- Behavioral: Exposure and response prevention
- Other: Inference-based cognitive therapy
|
Interventional
|
Not Applicable |
- Centre de Recherche de l'Institut Universitaire en santé Mentale de Montréal
- Canadian Institutes of Health Research (CIHR)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- assessment of change in obsessive and compulsive symptoms and severity
- establishing baseline level of overvalued ideation
- assess change in level of overvalued ideation
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03677947 |
2018-1463 |
RCT_TOC_16 |
September 1, 2018 |
March 31, 2022 |
March 31, 2023 |
September 19, 2018 |
September 19, 2018 |
|
- Centre de recherche de l'Institut universitaire en santé mentale de Montréal
Montréal-Est, Quebec, Canada
|
|
| 16 |
NCT03182075 |
Recruiting |
Computerized Training for Individuals Diagnosed With Obsessive-Compulsive and Related Disorders |
- Obsessive Compulsive Disorder
|
- Behavioral: Computerized Training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- Yale-Brown Obsessive Compulsive Scale (for participants diagnosed with OCD)
- Savings Inventory Revised Scale (for participants diagnosed with hoarding disorder)
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03182075 |
40185 |
EmRT |
April 30, 2018 |
July 1, 2020 |
October 1, 2020 |
June 9, 2017 |
May 7, 2018 |
|
- Stanford University
Stanford, California, United States
|
|
| 17 |
NCT03068429 |
Recruiting |
Fear Conditioned Response in Healthy Subjects and in OCD Patients Pre and Post Treatment With Sertraline. |
- Obsessive-Compulsive Disorder
|
- Drug: Sertraline Hydrochloride
|
Interventional
|
Phase 4 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Main behavioral measure (extinction retention index)
- Main functional neuroimaging measure
- Main treatment outcome measure
- (and 10 more...)
|
48 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03068429 |
0182/11 |
FEARCON |
December 1, 2016 |
February 20, 2019 |
June 30, 2019 |
March 1, 2017 |
October 27, 2017 |
|
- Institute of Psychiatry, Hospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo
Sao Paulo, Brazil
|
|
| 18 |
NCT03393078 |
Recruiting |
Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment for Obsessive Compulsive Disease |
- Obsessive-Compulsive Disorder
- Transcranial Magnetic Stimulation
- Functional Magnetic Resonance Imaging
- Event-Related Potentials
|
- Device: transcranial magnetic stimulation with real coil
- Device: transcranial magnetic stimulation with sham coil
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Symptom improvement assessed by the Yale-Brown Obsessive Compulsive Scale
- Symptom improvement assessed by the Padua Inventory-Washington State University Revision
- Stop-Signal Task
- (and 3 more...)
|
60 |
All |
18 Years to 50 Years (Adult) |
NCT03393078 |
AnhuiMU |
|
August 1, 2017 |
January 1, 2019 |
December 31, 2019 |
January 8, 2018 |
January 8, 2018 |
|
- Anhui Medical University
Hefei, Anhui, China
|
|
| 19 |
NCT03263546 |
Recruiting |
Internet-delivered CBT for Paediatric OCD |
- Obsessive-Compulsive Disorder
|
- Behavioral: Internet-delivered cognitive behavioral therapy (ICBT)
- Behavioral: Cognitive behavioral therapy (CBT)
|
Interventional
|
Not Applicable |
- Karolinska Institutet
- Stockholm County Council, Sweden
- Vastra Gotaland Region
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Children's Yale Brown Obsessive-Compulsive Scale (CY-BOCS)
- Clinical global impression severity (CGI-S)
- Clinical global impression improvement (CGI-I)
- (and 9 more...)
|
152 |
All |
7 Years to 17 Years (Child) |
NCT03263546 |
REPN 2017/1070-31/1 |
|
October 6, 2017 |
June 30, 2020 |
December 31, 2025 |
August 28, 2017 |
November 17, 2017 |
|
- BUP Specialmottagning
Göteborg, Sweden - Child and Adolescent Psychiatry (CAP) research center
Stockholm, Sweden
|
|
| 20 |
NCT03356483 |
Recruiting |
Efficacy of Psilocybin in OCD: a Double-Blind, Placebo-Controlled Study. |
- Obsessive-Compulsive Disorder
|
- Drug: Psilocybin (0.25mg/kg)
- Drug: Niacin (250mg)
|
Interventional
|
Phase 1 |
- Yale University
- Heffter Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in severity of OCD symptoms, which will be measured by The Yale-Brown Obsessive-Compulsive Scale (Y-BOCS). The Primary Outcome Measure will be collected at baseline and 48 hours, assessing change from baseline at 48 hours.
- Acute Yale-Brown Obsessive-Compulsive Scale (A-YBOCS)
- Changes in brain connectivity, which will be measured with functional Magnetic Imaging Resonance (fMRI).
- (and 21 more...)
|
30 |
All |
21 Years to 55 Years (Adult) |
NCT03356483 |
2000020355 |
|
November 13, 2018 |
January 2022 |
July 2022 |
November 29, 2017 |
November 15, 2018 |
|
- Connecticut Mental Health Center
New Haven, Connecticut, United States
|
|
| 21 |
NCT02407288 |
Recruiting |
tDCS as an add-on Treatment in SSRI-resistant OCD |
- Obsessive-Compulsive Disorder
|
- Device: transcranial dirrect current stimulation
- Device: Sham tDCS
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- score improvement on the Yale Brown Obsessive and Compulsive Scale after one month
- Number of responders on the YBOCS
- score improvement on the Yale Brown Obsessive and Compulsive Scale after 3 months
|
46 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02407288 |
CSR G01 |
TDCSTOC |
March 12, 2015 |
June 2018 |
June 2018 |
April 2, 2015 |
May 8, 2017 |
|
- Centre Hospitalier Le Vinatier
Bron, France
|
|
| 22 |
NCT03128749 |
Recruiting |
Mindfulness-Based Cognitive Therapy: Efficacy and fMRI-based Response Predictors in a Group of OCD Patients |
- Obsessive-Compulsive Disorder
|
- Behavioral: Mindfulness Based Intervention
- Drug: Treatment as Usual
|
Interventional
|
Not Applicable |
- Corporacion Parc Tauli
- Hospital Universitari de Bellvitge
- Children's Hospital Medical Center, Cincinnati
- University of Arizona
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Y-BOCS:
- Change in OCI-R:
- Change in OBQ-44:
- (and 17 more...)
|
60 |
All |
18 Years to 50 Years (Adult) |
NCT03128749 |
CorporacionPT CIR2016/030 |
|
January 11, 2018 |
December 2018 |
December 2018 |
April 25, 2017 |
January 17, 2018 |
|
- Corporacion Sanitaria Parc Taulí
Sabadell, Barcelona, Spain
|
|
| 23 |
NCT03457675 |
Recruiting |
Development of Adaptive Deep Brain Stimulation for OCD |
- Obsessive-Compulsive Disorder
|
- Device: Activa PC+S DBS implant for OCD
- Other: One Month Blinded Discontinuation Period
|
Interventional
|
Not Applicable |
- Baylor College of Medicine
- University of Pittsburgh
- Brown University
- (and 3 more...)
|
Other / NIH / Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percent of subjects that display biomarkers of OCD-related distress
- Percent of subjects that display biomarkers of DBS-induced hypomania
- Change in Yale-Brown Obsessive Compulsive Scale (Y-BOCS) Rating OCD Symptom Severity
|
2 |
All |
21 Years to 70 Years (Adult, Older Adult) |
NCT03457675 |
H40255
1UH3NS100549
49340 |
|
July 11, 2018 |
June 2022 |
June 2023 |
March 7, 2018 |
January 17, 2019 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States - Brown University
Providence, Rhode Island, United States - Baylor College of Medicine
Houston, Texas, United States
|
|
| 24 |
NCT03420495 |
Recruiting |
Decision-making Impairments in OCD: An Integrated Behavioral Economics Model |
- Obsessive-Compulsive Disorder
|
- Behavioral: Decision-Making Tasks
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
- Obsessive Compulsive Foundation
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Ambiguity aversion score on the Risk and Ambiguity Task
- Average adjusted pump scores on the Balloon Analogue Risk Task (BART)
- Money spent on draws to decision (DTD) in the Beads Task
- Intolerance of Uncertainty Scale (IUS-12)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03420495 |
2017P002668 |
|
May 3, 2018 |
August 30, 2019 |
August 30, 2019 |
February 2, 2018 |
May 7, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 25 |
NCT02624596 |
Recruiting |
Understanding How Ketamine Brings About Rapid Improvement in OCD |
- Obsessive-Compulsive Disorder
|
- Drug: Ketamine
- Drug: Midazolam
|
Interventional
|
Phase 2 |
- Stanford University
- University of Connecticut
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)
- Regional gamma-aminobutyric acid, glutamate/glutamine levels derived from 3T Magnetic Resonance Spectroscopy
|
120 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02624596 |
IRB-34622 |
MKET |
June 2016 |
June 2020 |
June 2021 |
December 8, 2015 |
May 7, 2018 |
|
- Stanford University
Stanford, California, United States
|
|
| 26 |
NCT02431845 |
Recruiting |
Pharmaco(Epi)Genetic Study of Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from baseline in the Yale-Brown Obsessive-Compulsive Scale
- Change from the baseline Montgomery-Asberg Depression Rating Scale
- Occurrence of any side effects during the SSRIs treatment
|
200 |
All |
19 Years to 60 Years (Adult) |
NCT02431845 |
4-2010-0577 |
|
January 2013 |
December 2023 |
December 2023 |
May 1, 2015 |
September 7, 2018 |
|
- Yonsei Univ. Health System Severance Hospital
Seoul, Korea, Republic of
|
|
| 27 |
NCT03463590 |
Recruiting |
Deep Brain Stimulation of the Bilateral Habenula for Treatment-Refractory Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Device: Bilateral surgical implantation of DBS system to habenula
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Y-BOCSII Score
- Change in OCI-R Score
- changes in the Hamilton Depression Scale(HAMD-17)
- (and 5 more...)
|
6 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03463590 |
Habenula DBS for OCD |
|
March 1, 2018 |
February 28, 2020 |
February 28, 2020 |
March 13, 2018 |
March 29, 2018 |
|
- Shanghai Ruijin Hospital Functional Neurosurgery
Shanghai, Shanghai, China
|
|
| 28 |
NCT03661905 |
Not yet recruiting |
Enhancing the Acceptability of Psychological Treatments for Obsessive-compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Other: Cognitive therapy
- Behavioral: Exposure and Response Prevention
|
Interventional
|
Not Applicable |
- Concordia University
- Université de Montréal
- McGill University
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Incidents of participants that drop-out of treatment
- Incidents of participants that refuse treatment
- Treatment and Acceptability Adherence Scale (TAAS; Milosevic, Levy, Alcolado & Radomsky, 2015)
- (and 3 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03661905 |
30006258 |
|
September 2018 |
January 2022 |
March 31, 2022 |
September 7, 2018 |
September 10, 2018 |
|
- Concordia University
Montréal, Quebec, Canada
|
|
| 29 |
NCT03601312 |
Not yet recruiting |
Randomized Controlled Trial of Standard ERP and OC-Go |
- Obsessive-Compulsive Disorder
|
- Behavioral: Exposure and Response Prevention
- Behavioral: OC-Go
|
Interventional
|
Not Applicable |
- University of California, Los Angeles
- Virtually Better, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Homework compliance
- Clinical Global Impression - Improvement Scale (acute)
- Clinical Global Impression - Improvement Scale (crossover)
|
32 |
All |
9 Years to 17 Years (Child) |
NCT03601312 |
R42MH111277-02 |
OC-GoPhaseII |
November 2018 |
April 2020 |
April 2020 |
July 26, 2018 |
October 12, 2018 |
|
- Univ. of California / Los Angeles / Semel Inst.
Los Angeles, California, United States
|
|
| 30 |
NCT03595098 |
Recruiting |
Treatment Effects of Family Based Cognitive Therapy in Children and Adolescents With Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder in Children
- Obsessive-Compulsive Disorder in Adolescence
|
- Behavioral: Family Based Cognitive Behavioural Therapy
- Behavioral: Family Based Psychoeducation/Relaxation Training
|
Interventional
|
Not Applicable |
- Anne Katrine Pagsberg
- Danish Research Centre for Magnetic Resonance
- Copenhagen Trial Unit, Center for Clinical Intervention Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) score
- health-related quality of life assesses with KIDSCREEN-52
- Occurrence of negative adverse events
|
128 |
All |
8 Years to 17 Years (Child) |
NCT03595098 |
TECTO-Trial-DP-395 |
TECTO |
August 28, 2018 |
September 2021 |
September 2021 |
July 23, 2018 |
September 10, 2018 |
|
- Child and Adolescent Mental Health Centre, Bispebjerg
Copenhagen, Denmark
|
|
| 31 |
NCT02844049 |
Recruiting |
European Study of Quality of Life in Resistant OCD Patients Treated by STN DBS |
- Obsessive-Compulsive Disorder
|
- Device: Deep Brain Stimulation
|
Interventional
|
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Assessment of the impact of DBS+BMT versus BMT alone on a measure of Quality of life in resistant OCD patients at 1-year follow-up
- Psychiatric assessment n°1
- Psychiatric assessment n°2
- (and 20 more...)
|
60 |
All |
18 Years to 69 Years (Adult, Older Adult) |
NCT02844049 |
38RC15.344 |
EQOLOC |
September 2016 |
December 2019 |
December 2021 |
July 26, 2016 |
April 2, 2018 |
|
- CHU Henri Mondor
Creteil, France - University Hospital of Grenoble Michallon
Grenoble, France - APHP La Pitié Salpêtrière
Paris, France - (and 6 more...)
|
|
| 32 |
NCT03767491 |
Not yet recruiting |
Waitlist-Control Trial of Smartphone CBT for Obsessive-Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
- Device: Smartphone-delivered CBT for OCD
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
- Telefónica S.A.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in scores on Yale-Brown Obsessive Compulsive Scale. This measure will be used to assess change from baseline to endpoint in OCD severity.
- Client Satisfaction Questionnaire (CSQ) at endpoint. This measure will be used to assess participant satisfaction with treatment at endpoint.
- Treatment completion rates
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03767491 |
2018P001669 |
|
April 1, 2019 |
June 1, 2020 |
September 1, 2020 |
December 6, 2018 |
December 6, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 33 |
NCT02437773 |
Recruiting |
Neurocircuit Mechanisms of OCD Across the Lifespan |
- Obsessive-Compulsive Disorder
|
- Behavioral: Cognitive Behavioral Therapy - Adolescents
- Behavioral: Stress Management Therapy - Adolescents
- Behavioral: Optional CBT - Adolescents
- (and 5 more...)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Brain activity as assessed by Magnetic Resonance Imaging (fMRI) scans
- OCD symptom severity measured by the Yale Brown Obsessive Compulsive Scale for adults or the Child Yale Brown Obsessive Compulsive Scale for adolescents.
|
220 |
All |
13 Years to 45 Years (Child, Adult) |
NCT02437773 |
HUM00091368 |
|
September 2014 |
July 2019 |
July 2019 |
May 8, 2015 |
January 15, 2019 |
|
- University of Michigan
Ann Arbor, Michigan, United States
|
|
| 34 |
NCT03299166 |
Recruiting |
BHV-4157 in Adult Subjects With Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Drug: BHV-4157
- Drug: Placebo
|
Interventional
|
Phase 2
Phase 3 |
- Biohaven Pharmaceuticals, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in the Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score
- Safety and tolerability assessed using the frequency of subjects with serious adverse events, adverse events leading to discontinuation, and adverse events judged to be related to study medication.
- Improvement in functional disability assessed using the Sheehan Disability Scale (SDS) total score.
- (and 2 more...)
|
226 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03299166 |
BHV4157-202 |
|
December 19, 2017 |
November 18, 2019 |
November 18, 2020 |
October 2, 2017 |
February 12, 2019 |
|
- Metropolitan Neuro Behavioral Institute
Chandler, Arizona, United States - Preferred Research Partners, Inc.
Little Rock, Arkansas, United States - Collaborative Neuroscience Network, LLC
Garden Grove, California, United States - (and 57 more...)
|
|
| 35 |
NCT01635569 |
Recruiting |
Clinical Outcomes in Pediatric Obsessive-Compulsive Disorder |
- Obsessive-compulsive Disorder
|
- Behavioral: Group-based family cognitive-behavioural therapy
- Other: Waitlist
|
Interventional
|
Not Applicable |
- University of British Columbia
- Michael Smith Foundation for Health Research
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Children's Yale Brown Obsessive-Compulsive Scale (CY-BOCS)
|
180 |
All |
5 Years to 18 Years (Child, Adult) |
NCT01635569 |
H12-01656 |
|
October 2012 |
June 2019 |
June 2019 |
July 9, 2012 |
September 13, 2018 |
|
- BC Children's Hospital Research Institute
Vancouver, British Columbia, Canada
|
|
| 36 |
NCT03244852 |
Not yet recruiting |
Patient-specific, Effective, and Rational Functional Connectivity Targeting for DBS in OCD |
- Obsessive-Compulsive Disorder
|
|
Observational
|
|
- Massachusetts General Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Yale-Brown Obsessive-Compulsive Scale (YBOCS)
- Yale-Brown Obsessive-Compulsive Scale (YBOCS) and Neural Correlates (1)
- Yale-Brown Obsessive-Compulsive Scale (YBOCS) and Neural Correlates (2)
- Yale-Brown Obsessive-Compulsive Scale (YBOCS) and Neural Correlates (3)
|
11 |
All |
21 Years to 64 Years (Adult) |
NCT03244852 |
2017P000882 |
PERFECT DBS |
September 2017 |
July 2018 |
June 2020 |
August 10, 2017 |
August 10, 2017 |
|
- Massachusetts General Hospital
Charlestown, Massachusetts, United States
|
|
| 37 |
NCT03300947 |
Recruiting |
Psilocybin for Treatment of Obsessive Compulsive Disorder |
- Obsessive-compulsive Disorder (OCD)
|
- Drug: Psilocybin 100 mcg/kg
- Drug: Psilocybin 300 mcg/kg
- Drug: Lorazepam 1 mg
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Acute effects on Obsessive-Compulsive symptom severity
- Acute Incidence of Treatment Emergent Adverse Events
- Repeated administration effects on Obsessive-Compulsive symptom severity
- (and 4 more...)
|
15 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03300947 |
1707613822 |
PSILOCD |
January 2, 2019 |
December 2020 |
July 2021 |
October 4, 2017 |
February 7, 2019 |
|
- University of Arizona
Tucson, Arizona, United States
|
|
| 38 |
NCT03304600 |
Recruiting |
tDCS for Treatment Resistant Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Device: Active stimulation
- Device: Sham stimulation
|
Interventional
|
Not Applicable |
- Centre Hospitalier Henri Laborit
- Ministry of Health, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Yale Brown Obsessive Compulsive Scale (YBOCS) score
- Yale Brown Obsessive Compulsive Scale (YBOCS)
- Yale Brown Obsessive Compulsive Scale (YBOCS),
- (and 6 more...)
|
100 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03304600 |
2016-A01983-48 |
tDCS-TOC |
November 3, 2017 |
November 2019 |
March 2020 |
October 9, 2017 |
December 8, 2017 |
|
- CHU de Nantes
Nantes, France - Centre Hospitalier Henri Laborit
Poitiers, France - C.H. Guillaume Regnier
Rennes, France - Clinique Psychiatrique Universitaire Tours-Nord, CHRU de Tours
Tours, France
|
|
| 39 |
NCT03649685 |
Not yet recruiting |
Repetitive Transcranial Magnetic Stimulation (rTMS) in the Treatment of Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Device: Continuous theta burst stimulation (cTBS)
- Device: shame rTMS
|
Interventional
|
Not Applicable |
- Shanghai Mental Health Center
- RenJi Hospital
- Shanghai 10th People's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Symptom improvement assessed by the Yale-Brown Obsessive Compulsive Scale
- The Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS)
- The Barratt Impulsiveness Scale-11 (BIS-11)
- (and 5 more...)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03649685 |
SMHC-OCD-003 |
|
February 20, 2019 |
October 31, 2021 |
October 31, 2021 |
August 28, 2018 |
January 17, 2019 |
|
- Shanghai Mental Health Center
Shanghai, Shanghai, China
|
|
| 40 |
NCT02773082 |
Recruiting |
Reclaim™ Deep Brain Stimulation (DBS) Therapy for Obsessive-Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder (OCD)
|
- Device: Reclaim™ DBS Therapy
|
Interventional
|
Not Applicable |
- The University of Texas Health Science Center, Houston
- Medtronic
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Efficacy as indicated by a decrease in obsessive compulsive symptoms as assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
- Safety as indicated by the number of Adverse Events
|
50 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02773082 |
HSC-MS-09-0520 |
DBS |
November 2018 |
April 2020 |
April 2020 |
May 16, 2016 |
October 19, 2018 |
|
- UT Health Science Center at Houston
Houston, Texas, United States
|
|
| 41 |
NCT02818088 |
Recruiting |
Cognitive Training in Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Behavioral: n-Back (Cognitive Training)
|
Interventional
|
Not Applicable |
- University of Stellenbosch
- University of Cape Town
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive Compulsive Scale (YBOCS)
- Cambridge neuropsychological test automated battery (CANTAB)
|
40 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02818088 |
S14/05/113 |
CTOCD |
February 2016 |
December 2019 |
December 2020 |
June 29, 2016 |
October 12, 2018 |
|
- Stellenbosch University
Cape Town, Western Cape, South Africa
|
|
| 42 |
NCT02955654 |
Not yet recruiting |
Acceptance and Commitment Therapy in SSRI-Resistant Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Behavioral: Acceptance and commitment therapy
- Drug: Aripiprazole
- Behavioral: Stress management training
|
Interventional
|
Not Applicable |
- Shanghai Mental Health Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale Brown Obsessive Compulsive Scale
- Beck Depression Inventory-II
- Acceptance and Action Questionnaire
- (and 4 more...)
|
135 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02955654 |
SMHC-OCD-002 |
|
September 1, 2017 |
December 2018 |
December 2018 |
November 4, 2016 |
May 1, 2017 |
|
|
|
| 43 |
NCT01949753 |
Recruiting |
Influence of Pregnenolone on Exposure Therapy in Obsessive-compulsive Disorder |
- Obsessive-compulsive Disorder (OCD)
|
- Behavioral: Exposure therapy with pharmacological facilitation
- Behavioral: Exposure therapy
|
Interventional
|
Phase 2 |
- Universitätsklinikum Hamburg-Eppendorf
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Subjective units of distress (SUD)
- Low/high frequency index of heart rate variability (L/HFI)
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01949753 |
PV4398 |
P-EX |
September 2013 |
December 2017 |
December 2018 |
September 24, 2013 |
August 3, 2017 |
|
- University Hospital Hamburg-Eppendorf
Hamburg, Germany
|
|
| 44 |
NCT03451409 |
Not yet recruiting |
Neurobiology of Sensory Phenomena in Obsessive-Compulsive Disorder |
- Obsessive Compulsive Disorder
|
- Diagnostic Test: Tasked based functional MRI (fMRI)
- Diagnostic Test: Eye Tracking Device
|
Interventional
|
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Brain activation in relation to sensory phenomena severity in patients with OCD
|
100 |
All |
18 Years to 60 Years (Adult) |
NCT03451409 |
17-01606 |
|
July 2018 |
January 2021 |
January 2022 |
March 1, 2018 |
May 10, 2018 |
|
|
|
| 45 |
NCT02867449 |
Recruiting |
Metacognitive Therapy for Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder (OCD)
|
- Behavioral: Metacognitive Therapy
- Behavioral: Exposure and Response Prevention
|
Interventional
|
Not Applicable |
- University of Leipzig
- Philipps University Marburg Medical Center
- German Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Symptom Severity (Yale Brown Obsessive-Compulsive Scale; Y-BOCS)
- Change in Symptom Severity (Padua Inventory; PI)
- Change in general psychopathology (Symptom Checklist-90-Revised, SCL-90-R)
- (and 12 more...)
|
70 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02867449 |
MCT_OCD |
|
June 2016 |
November 2018 |
April 2019 |
August 16, 2016 |
June 26, 2018 |
|
- Leipzig University
Leipzig, Germany - Philipps University Marburg
Marburg, Germany
|
|
| 46 |
NCT03672565 |
Recruiting |
SMART ERP for the Behavioral Treatment of Youth With Obsessive Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
- Behavioral: Phase One: Standardized Brief Intensive ERP
- Behavioral: Phase Two: Flexible Patient Driven Intensive ERP
- Behavioral: Follow-Up Phase: Booster Calls
|
Interventional
|
Not Applicable |
- University of British Columbia
- Michael Smith Foundation for Health Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in OCD symptom severity (i.e., percentage of youth achieving remission) following Treatment Phase One both within and between treatment settings (hospital vs. community)
- Change in OCD symptom severity between pre- and post-treatment for both treatment phases both within and between treatment settings
- Number of sessions utilized by families used within treatment phase two both within and between treatment settings
- (and 2 more...)
|
100 |
All |
7 Years to 19 Years (Child, Adult) |
NCT03672565 |
H18-01654 |
|
October 1, 2018 |
August 27, 2021 |
August 27, 2021 |
September 14, 2018 |
February 15, 2019 |
|
- BC Children's Hospital Research Institute
Vancouver, British Columbia, Canada
|
|
| 47 |
NCT02334644 |
Recruiting |
Probiotic Treatment in Adult Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Dietary Supplement: Probiotic Formula (Lactobacillus helveticus R0052 and Bifidobacterium longum R0175)
- Dietary Supplement: Placebo
|
Interventional
|
Phase 4 |
- McMaster University
- Hamilton Health Sciences Corporation
- Lallemand Health Solutions
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale Brown Obsessive-Compulsive Scale [YBOCS]
- Clinical Global Impression - Improvement ≤ 2 [CGI-I]
- Mean change from baseline on the following scales: Quality of Life and Employment Satisfaction Questionnaire
- (and 5 more...)
|
64 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02334644 |
15-049 |
|
April 2015 |
April 2019 |
August 2019 |
January 8, 2015 |
April 11, 2018 |
|
- MacAnxiety Research Centre
Hamilton, Ontario, Canada
|
|
| 48 |
NCT03273699 |
Recruiting |
Mindfulness Meditation Utilizing an EEG Biofeedback Device for the Treatment for Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Not Applicable |
- Sunnybrook Health Sciences Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive Compulsive Scale (YBOCS)
- Obsessive Compulsive Inventory
- Obsessive Beliefs Questionnaire
- (and 5 more...)
|
100 |
All |
18 Years to 60 Years (Adult) |
NCT03273699 |
196-2016 |
|
April 10, 2017 |
December 31, 2018 |
June 30, 2019 |
September 6, 2017 |
September 6, 2017 |
|
- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
|
|
| 49 |
NCT02285699 |
Recruiting |
The Gut Microbiota in Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Not Applicable |
- McMaster University
- Hamilton Health Sciences Corporation
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Yale Brown Obsessive Compulsive Scale
- Clinical Global Impression - Improvement
- Obsessive-Compulsive Inventory - Revised (OCI-R)
- (and 3 more...)
|
25 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02285699 |
14-722 |
|
November 2014 |
December 2019 |
March 2020 |
November 7, 2014 |
April 11, 2018 |
|
- MacAnxiety Research Centre
Hamilton, Ontario, Canada
|
|
| 50 |
NCT02355002 |
Recruiting |
Transcranial Magnetic Stimulation (TMS) in Obsessive Compulsive Disorder (OCD): Mechanisms and Biomarkers |
- Obsessive Compulsive Disorder
|
- Device: Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Obsessive compulsive symptoms as measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
- Obsessive compulsive beliefs as measured by Obsessive-Compulsive Beliefs Questionnaire (OBQ)
- Total number of obsessive symptoms is reduced as measured by Obsessive-Compulsive Inventory Questionnaire (OCI)
|
58 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02355002 |
2014P002560 |
TMSOCD |
May 2015 |
January 2020 |
January 2020 |
February 4, 2015 |
February 15, 2019 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 51 |
NCT02467374 |
Recruiting |
Fear Extinction and Mechanisms of Change in Obsessive Compulsive Disorder |
- Obsessive Compulsive Disorder
|
- Behavioral: Behavior Therapy
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Obsessive compulsive symptoms as measured by Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
|
40 |
All |
18 Years to 60 Years (Adult) |
NCT02467374 |
2014P002325 |
|
December 2014 |
September 2019 |
September 2019 |
June 10, 2015 |
February 15, 2019 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 52 |
NCT02541968 |
Recruiting |
Internet-based vs Face-to-face Cognitive Behavioural Therapy for Obsessive-compulsive Disorder |
- Obsessive-compulsive Disorder
|
- Behavioral: Cognitive-behavioral therapy (face-to-face)
- Behavioral: Internet-based Cognitive-behavioral therapy
- Behavioral: Internet-based Cognitive-behavioral therapy without therapist support
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive-Compulsive Scale (Y-BOCS)
- Clinical Global Impression - Severity (CGI-S)
- Global Assessment of Functioning (GAF)
- (and 14 more...)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT02541968 |
OCD F2F vs ICBT |
|
August 2015 |
December 2018 |
March 2019 |
September 4, 2015 |
August 9, 2018 |
|
- Mottagningen för Tvångssyndrom
Huddinge, Sweden
|
|
| 53 |
NCT03184454 |
Recruiting |
Combined Cortical/Subcortical Recording and Stimulation as a Circuit-Oriented Treatment for Obsessive-Compulsive Disorder |
- Obsessive Compulsive Disorder
|
- Device: Medtronic PC+S Deep Brain Stimulation
|
Interventional
|
Phase 2 |
- Massachusetts General Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive-Compulsive Scale (YBOCS)
- Montgomery-Asberg Depression Rating Scale (MADRS)
- Clinical Global Impressions (CGI) Severity and Change scale
- Patient Global Impressions (PGI) scale
|
5 |
All |
21 Years to 64 Years (Adult) |
NCT03184454 |
2015P000456 |
|
October 2016 |
October 2021 |
October 2021 |
June 12, 2017 |
June 12, 2017 |
|
- Massachusetts General Hospital
Charlestown, Massachusetts, United States
|
|
| 54 |
NCT03638791 |
Recruiting |
Microbiome in Obsessive-compulsive Disorder |
- Obsessive-Compulsive Disorder
- Microbiota
|
- Behavioral: Exposure and response inhibition
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Alpha diversity
- Beta diversity
- Correlation between microbiota diversity and symptom severity
- Change in microtioba diversity before and after ERP treatment
|
90 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03638791 |
Microbiome in OCD |
MIO |
December 5, 2018 |
January 1, 2020 |
January 1, 2021 |
August 20, 2018 |
December 5, 2018 |
|
- M46: Karolinska Universitetssjukhuset, Psykiatri Sydväst
Stockholm, Huddinge, Sweden
|
|
| 55 |
NCT02018185 |
Recruiting |
Study of Magnetic Brain Stimulation in Treatment of Obsessive Compulsive Disorder |
- Obsessive Compulsive Disorder
|
- Device: Transcranial Magnetic Stimulation
- Device: Sham Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
- University of Manitoba
- Manitoba Medical Service Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in obsessive and compulsive symptom severity (Yale-Brown Obsessive Compulsive Scale)
|
30 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02018185 |
B2013:144 |
rTMS |
January 2014 |
July 2019 |
October 2019 |
December 23, 2013 |
December 4, 2018 |
|
- St. Boniface Hospital
Winnipeg, Manitoba, Canada
|
|
| 56 |
NCT03476902 |
Recruiting |
Feasibility, Acceptability, and Preliminary Efficacy of a Mobile App (nOCD) for OCD |
- Obsessive Compulsive Disorder (OCD)
|
- Behavioral: Therapist assisted mobile intervention
|
Interventional
|
Not Applicable |
- New York State Psychiatric Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility and acceptability of using a therapist assisted mobile app using the System Usability Scale (SUS).
- Effect of therapist assisted mobile app on OCD symptoms as assessed by the Yale-Brown Obsessive Compulsive Scale (Y-BOCS).
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03476902 |
7572 |
nOCD |
October 27, 2017 |
October 27, 2019 |
December 27, 2019 |
March 26, 2018 |
December 5, 2018 |
|
- New York State Psychiatric Institute
New York, New York, United States
|
|
| 57 |
NCT03348930 |
Recruiting |
Tolcapone in Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale Brown Obsessive Compulsive Scale (Y-BOCS)
- Clinical Global Impression- Severity and Improvement (CGI)
- Sheehan Disability Scale (SDS)
- (and 2 more...)
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03348930 |
17-1379 |
|
March 20, 2018 |
January 2020 |
January 2020 |
November 21, 2017 |
January 21, 2019 |
|
- University of Chicago
Chicago, Illinois, United States
|
|
| 58 |
NCT02620085 |
Recruiting |
Thyroid Disease and Personality Study |
|
- Procedure: blood sampling
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Psychological distress in scores measured using the Brief Symptom Rating Scale
|
500 |
All |
20 Years to 85 Years (Adult, Older Adult) |
NCT02620085 |
201107013RC |
TPS |
July 2011 |
July 2021 |
July 2021 |
December 2, 2015 |
December 2, 2015 |
|
- Shyang-Rong Shih
Taipei, Taiwan
|
|
| 59 |
NCT00182520 |
Recruiting |
Efficacy of Adding Topiramate to Current Treatment in Refractory Obsessive Compulsive Disorder (OCD) |
- Obsessive Compulsive Disorder
|
- Drug: Topiramate
- Drug: placebo
|
Interventional
|
Phase 4 |
- McMaster University
- Janssen-Ortho Inc., Canada
- Hamilton Health Sciences Corporation
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS)
- Clinical Global Impression - Improvement ≤ 2
- Montgomery Asberg Depression Rating Scale
- (and 4 more...)
|
48 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00182520 |
01-133 |
|
January 2002 |
February 2019 |
April 2019 |
September 16, 2005 |
April 10, 2018 |
|
- MacAnxiety Research Centre
Hamilton, Ontario, Canada
|
|
| 60 |
NCT03179839 |
Recruiting |
The Study of Mindfulness Based Cognitive Therapy and Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Behavioral: Mindfulness-based Cognitive Therapy
- Behavioral: Psycho-education Program
- Drug: sertraline, fluvoxamine
|
Interventional
|
Not Applicable |
- Shanghai Mental Health Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive-Compulsive Scale
- Hamilton Anxiety Scale
- Hamilton Depression Scale-24
|
120 |
All |
18 Years to 54 Years (Adult) |
NCT03179839 |
MBCT2017 |
|
January 20, 2017 |
December 1, 2018 |
February 20, 2019 |
June 7, 2017 |
July 2, 2017 |
|
- Clinical psychiatrist
Shanghai, Shanghai, China
|
|
| 61 |
NCT03211221 |
Recruiting |
rTMS Over the Supplementary Motor Area for Treatment-resistant Obsessive-compulsive Disorder. |
- Obsessive-Compulsive Disorder
|
- Device: rTMS (repetitive transcranial magnetic stimulation)
|
Interventional
|
Phase 2 |
- CNS Onlus
- University of Florence
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- rTMS effects on OC symptoms
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03211221 |
Pallanti |
rTMSOCD |
March 1, 2017 |
March 1, 2019 |
December 1, 2019 |
July 7, 2017 |
July 7, 2017 |
|
- Stefano Pallanti
Florence, I, Italy
|
|
| 62 |
NCT02450695 |
Recruiting |
rTMS in Treatment Refractory Obsessive-Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Not Applicable |
- McMaster University
- St. Joseph's Healthcare Hamilton
- Hamilton Health Sciences Corporation
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale Brown Obsessive Compulsive Scale
- Barratt Impulsiveness Scale
- Hamilton Anxiety rating Scale
- (and 2 more...)
|
25 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02450695 |
0190 |
|
July 2016 |
December 2018 |
|
May 21, 2015 |
April 11, 2018 |
|
- MacAnxiety Research Center
Hamilton, Ontario, Canada
|
|
| 63 |
NCT03156335 |
Recruiting |
Trial of MR-guided Focused Ultrasound (MRgFUS) Bilateral Capsulotomy for the Treatment of Refractory Obsessive-compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
- Device: Focused Ultrasound
|
Interventional
|
Not Applicable |
- Sunnybrook Health Sciences Centre
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Device Feasibility
|
- Incidence of Treatment-Emergent Adverse Events [Safety]
- Clinically meaningful reduction in symptoms [Efficacy]
|
10 |
All |
20 Years to 80 Years (Adult, Older Adult) |
NCT03156335 |
002-2017 |
|
April 20, 2017 |
April 2019 |
April 2019 |
May 17, 2017 |
August 3, 2018 |
|
- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada
|
|
| 64 |
NCT00994786 |
Recruiting |
A Study of Pregabalin (Lyrica) Augmentation in Serotonin Reuptake Inhibitor-Refractory Obsessive Compulsive Disorder |
- Obsessive-Compulsive Disorder
|
- Drug: pregabalin
- Drug: Placebo
|
Interventional
|
Phase 4 |
- McMaster University
- Pfizer
- Hamilton Health Sciences Corporation
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale-Brown-Obsessive-Compulsive-Scale
- Clinical Global Impression - Improvement
- Montgomery Asberg Depression Rating Scale
- (and 6 more...)
|
66 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00994786 |
06-273 |
|
January 2009 |
January 2019 |
March 2019 |
October 14, 2009 |
April 10, 2018 |
|
- MacAnxiety Research Centre
Hamilton, Ontario, Canada
|
|
| 65 |
NCT02377375 |
Recruiting |
Deep Brain Stimulation (DBS) for Obsessive Compulsive Disorder (OCD): Improving Targeting Precision |
- Obsessive-Compulsive Disorder
|
- Procedure: Micro-assisted technique
- Procedure: Standard technique
|
Interventional
|
Not Applicable |
- Universitaire Ziekenhuizen Leuven
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Millimeter difference in position between planned and actual target
|
10 |
All |
20 Years to 65 Years (Adult, Older Adult) |
NCT02377375 |
S57471 |
|
January 2015 |
December 2019 |
|
March 3, 2015 |
January 27, 2016 |
|
- UZ Leuven
Leuven, Vlaams-Brabant, Belgium
|
|
| 66 |
NCT03459456 |
Recruiting |
Measuring Automated Behavioral Observations & Vocal Expressions (ABOVE) |
- OCD
- Obsessive-Compulsive Disorder
|
- Behavioral: Provocation OC task (Provoc)
- Behavioral: Trier Social Stress Test (TSST)
- Behavioral: Exposure provocation task
|
Observational
|
|
- Baylor College of Medicine
- Brown University
- University of Pittsburgh
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Change in brain activity
- Change in Heart Rate
|
27 |
All |
21 Years to 70 Years (Adult, Older Adult) |
NCT03459456 |
H41632 |
ABOVE |
December 11, 2018 |
February 2019 |
May 2019 |
March 9, 2018 |
January 15, 2019 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States - Brown University
Providence, Rhode Island, United States - Baylor College of Medicine
Houston, Texas, United States
|
|
| 67 |
NCT03651869 |
Not yet recruiting |
Effects of Nicotine in Tobacco Smokers |
- Obsessive-compulsive Disorders and Symptoms
- Smoking, Tobacco
- Smoking (Tobacco) Addiction
- Withdrawal Nicotine
|
- Drug: Cigarette
- Drug: Reduced Nicotine Cigarette
- Drug: Nicotine patch
- Drug: Placebos
|
Interventional
|
Phase 1 |
- University of Southern California
- Illinois Institute of Technology
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Health Services Research
|
- Positive and Negative Affect Schedule state version
- Smoking Reinstatement Task
- The emotional Stroop task optimized for OCD
- (and 3 more...)
|
220 |
All |
21 Years and older (Adult, Older Adult) |
NCT03651869 |
28IR-0063 |
|
February 4, 2019 |
July 2023 |
July 2023 |
August 29, 2018 |
February 5, 2019 |
|
- University of Southern California
Los Angeles, California, United States
|
|
| 68 |
NCT03826693 |
Not yet recruiting
New |
Efficacy of Nitrous Oxide in OCD: Pilot Study |
- Obsessive-Compulsive Disorder
|
- Drug: Nitrous Oxide
- Drug: Nitrogen
|
Interventional
|
Phase 2 |
- Stanford University
- Brain & Behavior Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement in the severity of OCD symptoms as measured by the Yale-Brown Obsessive Compulsive Scale (YBOCS)
|
45 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03826693 |
48077 |
|
April 2019 |
April 2021 |
April 2022 |
February 1, 2019 |
February 1, 2019 |
|
- Stanford University
Stanford, California, United States
|
|
| 69 |
NCT03584945 |
Not yet recruiting |
Task Control Circuit Targets for Obsessive Compulsive Behaviors in Children |
- Obsessive-compulsive Disorders and Symptoms in Children
|
- Behavioral: Cognitive Behavioral Therapy
- Other: Community Referral as appropriate
|
Interventional
|
Not Applicable |
- University of Michigan
- Columbia University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Blood oxygen-level dependent (BOLD) functional MRI signal during a cognitive conflict task
- Child Yale-Brown Obsessive Compulsive Scale
- Blood oxygen-level dependent (BOLD) functional connectivity MRI of task control circuits
- Diffusion tensor imaging (fractional anisotropy, FA) in task control circuit regions
|
180 |
All |
7 Years to 12 Years (Child) |
NCT03584945 |
HUM00144074 |
|
March 1, 2019 |
September 2022 |
September 2022 |
July 12, 2018 |
February 1, 2019 |
|
|
|
| 70 |
NCT02421315 |
Recruiting |
Overlapping Neural Circuits in Pediatric OCD |
- Obsessive Compulsive Disorder
|
- Behavioral: Exposure & Response Prevention (EX/RP) and when indicated medication treatment
|
Interventional
|
Not Applicable |
- New York State Psychiatric Institute
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change from baseline in brain activation (fMRI) after therapy
- Change from baseline in fractional anisotropy (Diffusion tensor imaging) after therapy
- Probabilistic Go/No-go reinforcement learning task
- (and 2 more...)
|
80 |
All |
5 Years to 17 Years (Child) |
NCT02421315 |
7006
R21MH101441 |
|
October 2014 |
May 2018 |
May 2018 |
April 20, 2015 |
February 14, 2018 |
|
- NY State Psychiatric Institute
New York, New York, United States
|
|
| 71 |
NCT03182101 |
Recruiting |
Quality Assessment in Exposure Therapy |
- Obsessive-Compulsive Disorder in Children
|
- Behavioral: Exposure Therapy
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical Global Impression Scales
|
300 |
All |
5 Years to 25 Years (Child, Adult) |
NCT03182101 |
1039342 |
|
September 13, 2017 |
September 2020 |
April 2021 |
June 9, 2017 |
May 18, 2018 |
|
- Emma Pendleton Bradley Hospital
Riverside, Rhode Island, United States
|
|
| 72 |
NCT03274440 |
Recruiting |
Effects of Marijuana on Symptoms of OCD |
- Obsessive-Compulsive Disorder
|
- Drug: Marijuana
- Other: Placebo
|
Interventional
|
Phase 1
Phase 2 |
- New York State Psychiatric Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Yale-Brown Obsessive-Compulsive Challenge Scale
|
20 |
All |
21 Years to 55 Years (Adult) |
NCT03274440 |
# 7405 |
ECOS |
October 1, 2017 |
January 2019 |
March 2019 |
September 7, 2017 |
November 9, 2018 |
|
- New York State Psychiatric Institute
New York, New York, United States
|
|
| 73 |
NCT03636022 |
Not yet recruiting |
Low-Cost, Virtual Reality System |
- Anxiety Disorder of Childhood
- Obsessive-Compulsive Disorder in Children
|
- Device: Virtual Reality
- Behavioral: Traditional Therapy
|
Interventional
|
Phase 2 |
- Minnesota HealthSolutions
- Mayo Clinic
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Spence Child Anxiety Scale
- Child Sheehan Disability Scale
- Exposure number
- (and 2 more...)
|
65 |
All |
7 Years to 17 Years (Child) |
NCT03636022 |
MinnesotaHealthSolutions |
|
March 1, 2020 |
May 30, 2020 |
May 30, 2020 |
August 17, 2018 |
January 25, 2019 |
|
|
|
| 74 |
NCT03799419 |
Not yet recruiting |
Cognitive Bias Modification for OCD |
- Obsessive-Compulsive Disorder
- Obsessive-compulsive Disorders and Symptoms
|
- Behavioral: Cognitive bias modification for interpretation bias
- Behavioral: Psychoeducation
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Change in Average Score on Obsessive Beliefs Questionnaire
- Change in Average Score on Yale-Brown Obsessive Compulsive Scale
- Change in Event-related potentials during interpretation bias task
- (and 5 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03799419 |
2017P002864 |
|
March 2019 |
March 2020 |
September 2020 |
January 10, 2019 |
January 11, 2019 |
|
|
|
| 75 |
NCT03528109 |
Not yet recruiting |
Improving Access to Child Anxiety Treatment |
- Obsessive-Compulsive Disorder
- Anxiety Disorders
- Pediatric Disorder
- Cognitive Behavior Therapy
|
- Behavioral: Exposure Therapy
|
Interventional
|
Not Applicable |
- Bradley Hospital
- Brown University
- Patient-Centered Outcomes Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Children's Yale-Brown Obsessive-Compulsive Scale
- Pediatric Anxiety Rating Scale
- Client Satisfaction Questionnaire-8
- (and 4 more...)
|
333 |
All |
5 Years to 18 Years (Child, Adult) |
NCT03528109 |
IHS-2017C1-6400 |
IMPACT |
July 1, 2018 |
April 1, 2023 |
May 1, 2024 |
May 17, 2018 |
May 23, 2018 |
|
|
|
| 76 |
NCT02022709 |
Recruiting |
Efficacy of Exposure and Response Prevention(ERP) and SSRIs in Chinese OCD Patients |
- Obsessive-Compulsive Disorder
- Anxiety Disorders
- Mental Disorders
|
- Drug: Fluoxetine
- Drug: Sertraline
- Drug: Paroxetine
- (and 3 more...)
|
Interventional
|
Phase 4 |
- Shanghai Mental Health Center
- Shanghai Municipal Science and Technology Commission
- Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- The change of Yale-Brown Obsessive-Compulsive Scale score
- The change of Beck Depression Inventory(BDI-II) score
- The change of Beck Anxiety Inventory(BAI) score
- (and 6 more...)
|
60 |
All |
16 Years to 65 Years (Child, Adult, Older Adult) |
NCT02022709 |
124119a8601
YG2013MS65 |
|
January 2014 |
October 2017 |
December 2017 |
December 30, 2013 |
April 27, 2017 |
|
- Shanghai Mental Health Center
Shanghai, Shanghai, China
|
|
| 77 |
NCT03473080 |
Recruiting |
An eHealth Intervention for Obsessive Compulsive Disorder in Youth With Autism Spectrum Disorder |
- Obsessive-Compulsive Disorder
|
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Children's Yale-Brown Obsessive Compulsive Scale
- Obsessive-compulsive inventory - child version
- Autism spectrum quotient (AQ-10)
- (and 15 more...)
|
18 |
All |
7 Years to 17 Years (Child) |
NCT03473080 |
BIP ASD/OCD pilot |
|
March 9, 2018 |
June 2020 |
June 2020 |
March 22, 2018 |
March 22, 2018 |
|
- BUP OCD and Related Disorders
Stockholm, Sweden
|
|
| 78 |
NCT03265015 |
Recruiting |
Theta Burst Stimulation for Compulsive Behavior Non-invasive Brain Stimulation Study |
- Compulsive Behavior
- Obsessive-Compulsive Disorder
|
- Behavioral: Habit Override Practice
- Other: Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- functional Magnetic Resonance Imaging (fMRI)
- Quantity of compulsive behaviors in response to laboratory triggers
- Duration of compulsive behaviors in response to laboratory triggers
- (and 6 more...)
|
70 |
All |
18 Years to 55 Years (Adult) |
NCT03265015 |
R21MH112770 |
|
September 15, 2017 |
January 2020 |
March 2020 |
August 29, 2017 |
February 4, 2019 |
|
- Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States
|
|
| 79 |
NCT03232502 |
Not yet recruiting |
Pharmacogenetics in Primary Care Psychotropics |
- Depression
- Obsessive-Compulsive Disorder
- Generalized Anxiety Disorder
|
- Diagnostic Test: Pharmacogenetic testing
|
Interventional
|
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient oriented outcome1- Clinical Improvement
- Patient oriented outcome2- Adverse effects
- Patient oriented outcome3- Time to Improvement
- Patient oriented outcome5- Visits
|
130 |
All |
18 Years and older (Adult, Older Adult) |
NCT03232502 |
Pending1 |
|
August 15, 2017 |
January 15, 2018 |
December 31, 2018 |
July 28, 2017 |
July 28, 2017 |
|
|
|
| 80 |
NCT01596608 |
Recruiting |
Magnetic Seizure Therapy (MST) for Treatment Resistant Depression, Schizophrenia, and Obsessive Compulsive Disorder |
- Depressive Disorder
- Schizophrenia
- Schizoaffective Disorder
- Obsessive-Compulsive Disorder
|
- Device: Magnetic Seizure Therapy (MagPro MST)
|
Interventional
|
Not Applicable |
- Centre for Addiction and Mental Health
- University Health Network, Toronto
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Score on rating scale that corresponds to diagnosis: i) Hamilton Rating Scale for Depression, 24-item (HRSD-24); or ii) Yale-Brown Obsessive Compulsive Scale (Y-BOCS); or iii) Brief Psychiatric Rating Scale (BPRS)
- Score on rating scale that corresponds to diagnosis: i) HRSD-24; or ii) Y-BOCS; or iii) BPRS
- Cognitive Functioning
- Neuroimaging (brain structure and activity)
|
250 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT01596608 |
145-2010 |
|
February 2012 |
November 2019 |
August 2020 |
May 11, 2012 |
January 9, 2019 |
|
- Centre for Addiction and Mental Health
Toronto, Ontario, Canada
|
|
| 81 |
NCT02320266 |
Recruiting |
Sensory Gating Measured With Microelectrode Recording (MER) During Deep Brain Stimulation (DBS) Surgery |
- Parkinson's Disease
- Essential Tremor
- Dystonia
- Obsessive Compulsive Disorder
|
|
Observational
|
|
- University of Colorado, Denver
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Changes in EEG (Measurement in response to paired auditory clicks.)
- Evaluation of SUA (Single unit analysis of brain response.)
- Evaluation of LFP (Local field potential of brain response.)
|
150 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02320266 |
14-0358 |
|
December 2014 |
December 2018 |
March 2019 |
December 19, 2014 |
October 2, 2018 |
|
- University of Colorado
Aurora, Colorado, United States
|
|
| 82 |
NCT03414619 |
Recruiting |
The Role of Cognitive Control in the Transdiagnostic Conceptualization of "Intrusive Thoughts" |
- Obsessive-Compulsive Disorder
- Generalized Anxiety Disorder
- Major Depressive Disorder
|
- Behavioral: Cognitive Control Tasks and Script Driven Imagery
|
Interventional
|
Not Applicable |
- Massachusetts General Hospital
- Health Resources in Action (HRiA)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Commission Errors on the Go/No Go Task
- Response time on the Stroop Color Word Test
- Perseverative Errors on the Wisconsin Card Sort Test
- (and 3 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03414619 |
2017P002114 |
|
May 18, 2018 |
September 30, 2019 |
September 30, 2019 |
January 30, 2018 |
September 18, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 83 |
NCT03239210 |
Recruiting |
Effects of Ondansetron in Obsessive-compulsive and Tic Disorders |
- Obsessive-Compulsive Disorder
- Tic Disorders
- Tourette Syndrome
|
- Drug: Ondansetron
- Drug: Placebo
|
Interventional
|
Phase 4 |
- New York University School of Medicine
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Sensory phenomena severity from baseline to 4 weeks
- Percent BOLD signal change
- Patient-Related Inventory of Side effects
|
60 |
All |
18 Years to 60 Years (Adult) |
NCT03239210 |
17-01608 |
|
June 16, 2017 |
April 2020 |
April 2020 |
August 3, 2017 |
August 1, 2018 |
|
- New York University School of Medicine
New York, New York, United States - The Nathan S. Kline Institute for Psychiatric Research
New York, New York, United States
|
|
| 84 |
NCT01210534 |
Recruiting |
Physiological Brain Atlas Development |
- Parkinson Disease
- Dystonia
- Tremors
- (and 2 more...)
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- optimal DBS target location
|
500 |
All |
7 Years to 90 Years (Child, Adult, Older Adult) |
NCT01210534 |
2010H0036 |
|
August 2010 |
August 2020 |
August 2025 |
September 28, 2010 |
January 10, 2019 |
|
- The Ohio Sate University
Columbus, Ohio, United States - The Ohio State University
Columbus, Ohio, United States
|
|
| 85 |
NCT02573246 |
Recruiting |
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study |
- Anxiety
- Depression
- Personality Disorders
- (and 5 more...)
|
- Behavioral: Cognitive Restructuring
- Device: rTMS
- Device: Sham rTMS
|
Interventional
|
Not Applicable |
- Duke University
- Brain & Behavior Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to return to heart rate baseline during the regulation period during training
- Time to return to heart rate baseline during the regulation period at follow up
- Acceptability, as measured by qualitative exit interview
- (and 4 more...)
|
105 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02573246 |
Pro00066383 |
|
March 2016 |
July 2019 |
July 2019 |
October 9, 2015 |
May 28, 2018 |
|
- Duke University Medical Center-Civitan Bldg
Durham, North Carolina, United States
|
|
| 86 |
NCT00575081 |
Recruiting |
Physiological Brain Atlas Development |
- Parkinson's Disease
- Obsessive Compulsive Disorder
- Dystonia
- (and 2 more...)
|
- Device: Stereotactic brain procedures
|
Observational
|
|
- Vanderbilt University Medical Center
- National Institute for Biomedical Imaging and Bioengineering (NIBIB)
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- To create an atlas that will allow physiological information to be assigned to anatomical locations in MRI space, utilizing non-rigid MRI normalization algorithms.
- To collate and analyze the physiological atlas in a statistical manner that allows doctors to understand and treat brain disease more precisely and based on population data.
|
5000 |
All |
1 Year to 90 Years (Child, Adult, Older Adult) |
NCT00575081 |
060232
1R01EB006136-01
2R01EB006136
1R41NS063705-01A1
9R42MH100007-03 |
Brain Atlas |
August 2006 |
July 2020 |
July 2020 |
December 17, 2007 |
November 13, 2017 |
|
- Vanderbilt Univeristy
Nashville, Tennessee, United States
|
|
| 87 |
NCT02305537 |
Recruiting |
Building an Outcomes Assessment Infrastructure to Assess Anxiety Treatment |
- Social Anxiety Disorder
- Specific Phobia
- Separation Anxiety Disorder
- (and 3 more...)
|
- Behavioral: McLean Anxiety Mastery Program
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Score in Spence Children's Anxiety Scale (SCAS; Spence 1997).
- Change in Score in Center for Epidemiolgic Studies Depression Scale (CES-D; Radloff 1977).
|
45 |
All |
9 Years to 18 Years (Child, Adult) |
NCT02305537 |
2014P000353 |
|
October 2014 |
October 2024 |
October 2030 |
December 2, 2014 |
March 21, 2018 |
|
- McLean Hospital
Cambridge, Massachusetts, United States
|
|
| 88 |
NCT03753737 |
Not yet recruiting |
Personality Disorders and Substance Use Disorders in a Sexual Context in the Man Having Sex With Other Men Population |
|
- Other: Questionnaires and semi-structured interview
|
Observational
|
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
|
74 |
Male |
18 Years and older (Adult, Older Adult) |
NCT03753737 |
69HCL18_0509 |
PSYCHEMS |
December 2018 |
September 2019 |
September 2019 |
November 27, 2018 |
January 1, 2019 |
|
- CSAPA - Service Hépato-gastroentérologie
Lyon, France
|
|
| 89 |
NCT03720795 |
Recruiting |
Stepped-Care Cognitive-Behavioral Treatment for Youth With ASD and Anxiety |
- Cognitive Behavioral Therapy
- Autism Spectrum Disorder
- Anxiety Disorders
- (and 4 more...)
|
- Behavioral: Stepped Care CBT
|
Interventional
|
Not Applicable |
- Baylor College of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 6-item Pediatric Anxiety Rating Scale
- Clinical Global Impression-Improvement
- Clinical Global Impression-Severity
|
200 |
All |
4 Years to 14 Years (Child) |
NCT03720795 |
BCM SC-CBT001 |
|
February 1, 2019 |
November 30, 2020 |
December 31, 2020 |
October 25, 2018 |
January 23, 2019 |
|
- Baylor College of Medicine
Houston, Texas, United States
|
|
| 90 |
NCT02998502 |
Recruiting |
The Use of a FDA Cleared, Drug-free, Breathing System for Anxiety and Panic Disorders in Children and Teens |
|
- Device: Freespira Breathing System
|
Interventional
|
Not Applicable |
- Johns Hopkins University
- Palo Alto Health Sciences, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Primary outcome is a score of Screen for Child Anxiety Related Disorders (SCARED) scale, the anxiety measuring scale.
- SCARED anxiety scale score
- End-tidal carbon dioxide (CO2)
- (and 5 more...)
|
60 |
All |
9 Years to 17 Years (Child) |
NCT02998502 |
IRB00097094 |
|
September 2016 |
June 2018 |
March 2019 |
December 20, 2016 |
July 13, 2018 |
|
- Johns Hopkins University
Baltimore, Maryland, United States
|
|
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