| 1 |
NCT00735384 |
Recruiting |
Muscle Force Assessment in the Intensive Care Unit and in Primary Myopathies |
|
|
Observational |
|
- University Hospital, Basel, Switzerland
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Skeletal Muscle Force in ICU Patients and Patients with Primary Myopathies
- Muscle forces pending on the Malignant Hyperthermia (MH) status of a patient (susceptible to MH or not susceptible to MH)
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT00735384 |
134/02
P21/08//A05/08 |
|
September 2006 |
December 2018 |
December 2018 |
August 14, 2008 |
January 16, 2018 |
|
- University of Basel Hospital
Basel, Switzerland
|
| 2 |
NCT01166854 |
Recruiting |
Characterization of Familial Myopathy and Paget Disease of Bone |
- Muscle Disorder
- Bone Disorder
|
- Device: Diffuse Optical Spectroscopy
|
Observational |
|
- University of California, Irvine
- Beckman Laser Institute University of California Irvine
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
|
25 |
All |
18 Years and older (Adult, Senior) |
NCT01166854 |
NIH/LAMMP-2007-5832 |
|
June 2010 |
June 2018 |
June 2018 |
July 21, 2010 |
February 13, 2018 |
|
- Beckman Laser Institute Medical clinic
Irvine, California, United States
|
| 3 |
NCT01417533 |
Recruiting |
A Natural History Study of Patients With GNE Myopathy |
- Hereditary Inclusion Body Myopathy
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- Therapeutics for Rare and Neglected Diseases (TRND)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- The baseline rate of progression of complications and its correlation with age of onset of the disease.
- The functional outcome measures (potential endpoints) to be used to test future therapeutic interventions.
- The identification of potential serum biomarkers (sialylated as disease markers and the correlation between muscle magnetic resonance imaging (MRI) findings with progression of the disease
- The rates of progression for individual subjects.
|
100 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01417533 |
110218
11-HG-0218 |
|
August 13, 2011 |
|
|
August 16, 2011 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 4 |
NCT03083652 |
Recruiting |
Effects of Neuromuscular Electrical Stimulation on Exercise Capacity in Respiratory Critically Ill Patients |
- Critical Illness Myopathy
|
- Device: Neuromuscular electrical stimulation
- Other: Sham
|
Interventional |
Not Applicable |
- Hospital Clinic of Barcelona
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Exercise capacity
- Muscle strength
- Body composition (fat free mass)
- Functional Capacity
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03083652 |
UVIR |
|
February 1, 2017 |
March 1, 2018 |
March 1, 2018 |
March 20, 2017 |
August 10, 2017 |
|
- Unidad de Vigilancia Intensiva Respiratoria (UVIR)
Barcelona, Spain
|
| 5 |
NCT01171573 |
Recruiting |
Investigating Genes in Patients With Polymyositis and Dermatomyositis |
|
|
Observational |
|
- Salford Royal NHS Foundation Trust
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- To identify any disease susceptibility genes associated with development and clinical characteristics of primary inflammatory muscle diseases, PM, DM and IBM.
|
1000 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01171573 |
Ollier-002 |
AOMIC |
January 2001 |
January 2019 |
January 2020 |
July 28, 2010 |
October 17, 2016 |
|
- Salford Royal NHS Foundation Trust
Manchester, United Kingdom
|
| 6 |
NCT03496389 |
Not yet recruiting
New |
Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction? |
- Muscle Weakness
- Anterior Cruciate Ligament Rupture
|
- Drug: Gabapentin
- Drug: Tramadol
- Drug: Panadol
|
Interventional |
Phase 2
Phase 3 |
- Hospital Authority, Hong Kong
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in from baseline quadriceps muscle strength
- Anterior-posterior knee stability
- Rotational laxity
- Functional outcome
|
30 |
All |
18 Years to 50 Years (Adult) |
NCT03496389 |
Gabapentin ACLR |
|
July 1, 2018 |
July 1, 2019 |
August 1, 2019 |
April 12, 2018 |
April 12, 2018 |
|
|
| 7 |
NCT03270163 |
Not yet recruiting |
Evaluation of Muscle Strength by Transcutaneous Electrical Stimulation |
|
- Diagnostic Test: Transcutaneous electrical stimulation
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire de Saint Etienne
- Laboratoire de Physiologie de l’Exercice
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Reproducibility
- Intensive care unit acquired muscle weakness (ICUAW)
|
15 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT03270163 |
1708055
2017-A00919-44 |
STRENGHT-ICU |
May 1, 2018 |
November 30, 2018 |
November 30, 2018 |
September 1, 2017 |
March 15, 2018 |
|
- Chu Saint-Etienne
Saint-etienne, France
|
| 8 |
NCT02833168 |
Recruiting |
Screening Questionnaire for Respiratory Muscle Weakness and Sleep-disordered Breathing in Neuromuscular Disorders |
|
- Other: patient-filled questionnaires
- Device: spiromanometry
|
Observational |
|
- Westfälische Wilhelms-Universität Münster
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Nocturnal hypercapnia tcCO2
|
90 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02833168 |
KSN_2016_1_MB |
|
April 2016 |
December 2016 |
December 2016 |
July 14, 2016 |
July 14, 2016 |
|
- University Hospital Münster, Department of Sleep Medicine and Neuromuscular Disorders
Münster, Germany - Bethanien Hospital
Solingen, Germany
|
| 9 |
NCT02746718 |
Recruiting |
Frequency of Pompe's Disease and Neuromuscular Etiologies in Patients With Restrictive Respiratory Failure Associated With Signs of Muscle Weakness |
|
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire de Nice
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Number of new cases of Pompe disease diagnosed by a positive DBS
- Number of new cases and etiologies of neuromuscular diseases diagnosed in patients with unexplained restriction of lung volumes
- Frequency and description of neurological symptoms associated with neuromuscular diseases to respiratory revelation
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT02746718 |
14-PP-13 |
POPS3 |
December 11, 2015 |
December 11, 2019 |
December 11, 2019 |
April 21, 2016 |
March 19, 2018 |
|
- CHU d'Angers
Angers, France - Centre hospitalier d'Argenteuil
Argenteuil, France - CHU de Brest
Brest, France - (and 18 more...)
|
| 10 |
NCT02893228 |
Recruiting |
Does Saline Injection Around Phrenic Nerve Reduce Incidence of Diaphragmatic Paresis Following Interscalene Block? |
|
- Procedure: Saline
- Drug: Levobupivacaine
|
Interventional |
Phase 4 |
- The Adelaide and Meath Hospital, incorporating The National Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Rate of diaphragmatic paresis recorded in the post-operative period identified by ultrasound assessment
- FEV1
- FVC
- (and 2 more...)
|
36 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02893228 |
AMNCH-A-SIPPIB |
|
October 2016 |
September 2018 |
November 2018 |
September 8, 2016 |
January 12, 2018 |
|
- Adelaide and Meath Hospital, Incorporating National Children Hospital
Tallagh, Dublin 24, Ireland
|
| 11 |
NCT00082108 |
Recruiting |
Myotonic Dystrophy and Facioscapulohumeral Muscular Dystrophy Registry |
- Myotonic Dystrophy
- Facioscapulohumeral Muscular Dystrophy
- Muscular Dystrophy
- (and 6 more...)
|
|
Observational |
|
- University of Rochester
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Patient reported outcomes
|
3000 |
All |
Child, Adult, Senior |
NCT00082108 |
NIAMS-104
U54NS048843 |
|
September 2000 |
June 2018 |
June 2018 |
April 30, 2004 |
August 15, 2017 |
|
- University of Rochester Medical Center, Department of Neurology
Rochester, New York, United States
|
| 12 |
NCT01933841 |
Recruiting |
The Impact of Quantitative Neuromuscular Monitoring in the PACU on Residual Blockade and Postoperative Recovery |
|
- Device: TOF-Watch SX
- Procedure: Notify the provider
|
Observational |
|
- Vanderbilt University Medical Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Decrease in incidence of postoperative residual curarization
- Decrease in the incidence of hemoglobin desaturation
- Decrease in need for reintubation
- (and 3 more...)
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT01933841 |
131282 |
|
August 2013 |
September 2018 |
September 2018 |
September 2, 2013 |
July 11, 2017 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
| 13 |
NCT03359473 |
Recruiting |
Study to Evaluate the Safety and Efficacy of 13 Weeks of the Selective Androgen Receptor Modulator (SARM) GSK2881078 in Chronic Obstructive Pulmonary Disease (COPD) |
|
- Drug: GSK2881078
- Drug: Matching Placebo
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in blood pressure from Baseline
- Change in heart rate from Baseline
- Change in electrocardiogram (ECG) from Baseline
- (and 25 more...)
|
100 |
All |
50 Years to 75 Years (Adult, Senior) |
NCT03359473 |
200182 |
|
February 28, 2018 |
July 1, 2019 |
July 1, 2019 |
December 2, 2017 |
March 26, 2018 |
|
- GSK Investigational Site
Jacksonville, Florida, United States - GSK Investigational Site
High Point, North Carolina, United States - GSK Investigational Site
Spartanburg, South Carolina, United States
|
| 14 |
NCT02960425 |
Recruiting |
Delivra Topical Creatine for Improving Muscular Power |
|
- Dietary Supplement: Delivra TM Livsport preworkout cream
- Dietary Supplement: Placebo
|
Interventional |
Phase 3 |
- University of Saskatchewan
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
|
- Change in average power across 5 set of 15 repetitions separated by 60s rest on an isokinetic dynamometer
- Adverse events recorded on adverse event forms
- Change in peak power across 5 set of 15 repetitions separated by 60s rest on an isokinetic dynamometer
|
132 |
All |
18 Years to 45 Years (Adult) |
NCT02960425 |
16-145a |
|
October 2016 |
November 2017 |
November 2017 |
November 9, 2016 |
December 29, 2016 |
|
- University of Guelph
Guelph, Ontario, Canada - University of Prince Edward Island
Charlottetown, Prince Edward Island, Canada - University of Saskatchewan
Saskatoon, Saskatchewan, Canada
|
| 15 |
NCT02847988 |
Recruiting |
Facilitating Functional Independence in Patients Receiving Prolonged Mechanical Ventilation |
|
- Device: Neuromuscular electrical Stimulation (NMES)
- Device: Sham Stimulation
|
Interventional |
Not Applicable |
- RML Specialty Hospital
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Time to reach independence in performing functional activity
- The percentage of patients who can perform functional activities independently
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02847988 |
AXJ014
R01NR016055 |
|
July 2016 |
June 2021 |
February 2022 |
July 28, 2016 |
May 2, 2017 |
|
- RML Specialty Hospital
Hinsdale, Illinois, United States
|
| 16 |
NCT02873559 |
Recruiting |
Effect of PROGRESSive Training and Teststerone in Older Frail Men |
|
- Drug: testosterone
- Other: Progressive muscle training
|
Interventional |
Phase 2
Phase 3 |
- University Hospital, Gentofte, Copenhagen
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Stand-up-and Sit-test
- Frequency and severity of falls via questionaire
- Balance ability,
- (and 33 more...)
|
196 |
Male |
70 Years and older (Senior) |
NCT02873559 |
Ethical protocol H-16020521 |
PROGRESS |
November 2016 |
August 2018 |
January 2019 |
August 19, 2016 |
August 29, 2017 |
|
- Karsten Overgaard
Hellerup, Danmark, Denmark - Medical Dept. O, Geriatric Section
Herlev, Denmark
|
| 17 |
NCT03301116 |
Recruiting |
Promoting Seniors' Health With Home Care Aides |
|
- Behavioral: Healthy Moves for Aging Well (Healthy Moves)
- Behavioral: Active Mind for Aging Well (Active Mind)
|
Interventional |
Phase 2 |
- University of Illinois at Chicago
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change from Baseline Function (Daily activity difficulties and dependency in older home care clients) at Month 4
- Short Physical Performance Battery (SPPB)
- Exercise-related social support from home care aides
- (and 3 more...)
|
300 |
All |
60 Years to 110 Years (Adult, Senior) |
NCT03301116 |
2016-0689
R01AG053675 |
|
September 1, 2017 |
May 31, 2020 |
April 30, 2021 |
October 4, 2017 |
October 6, 2017 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States
|
| 18 |
NCT03240640 |
Recruiting |
Effects of Inspiratory Muscle Training on Shortness of Breath (Dyspnea) and Postural Control in Patients With COPD |
- Copd
- Inspiratory Muscle Weakness
|
- Procedure: Inspiratory Muscle Strength Training
- Procedure: Inspiratory Muscle Endurance Training
|
Interventional |
Not Applicable |
- Katholieke Universiteit Leuven
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Dyspnea (Borg CR-10 scale)
- Center of pressure displacement
- Maximal inspiratory pressure (Pi,max)
- (and 15 more...)
|
24 |
All |
40 Years to 90 Years (Adult, Senior) |
NCT03240640 |
S58513 |
|
February 1, 2017 |
December 31, 2017 |
January 31, 2018 |
August 7, 2017 |
August 8, 2017 |
|
- University Hospital Leuven
Leuven, Belgium
|
| 19 |
NCT01270516 |
Recruiting |
Effect of EPA and HMB on Strength in ICU Patients |
|
- Drug: HMB, hydroxymethylbutyrate
- Drug: EPA, eicosapentaenoic acid
- Drug: Saline
|
Interventional |
Not Applicable |
- Gerald Supinski
- University of Kentucky
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement of skeletal muscle strength for one of the drugs compared to placebo
- duration of mechanical ventilation
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT01270516 |
Diaphragm EPA HMB |
|
January 2014 |
October 2017 |
October 2017 |
January 5, 2011 |
April 27, 2017 |
|
- Chandler Hospital
Lexington, Kentucky, United States
|
| 20 |
NCT03400540 |
Recruiting |
What is the Best Verbal Instruction for Contraction the Pelvic Floor Muscles? |
- Pelvic Floor Muscle Weakness
|
- Diagnostic Test: verbal instruction
|
Interventional |
Not Applicable |
- University of Haifa
- Ariel University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- urinary bladder displacement in millimeters during first verbal instruction
- urinary bladder displacement in millimeters during second verbal instruction
- urinary bladder displacement in millimeters during third verbal instruction
- (and 6 more...)
|
80 |
All |
18 Years to 40 Years (Adult) |
NCT03400540 |
AU-NBA-20171221 |
|
January 22, 2018 |
April 2018 |
June 2018 |
January 17, 2018 |
January 23, 2018 |
|
- Ariel University, Department of Physical Therapy
Ariel, Israel
|
| 21 |
NCT02508311 |
Recruiting |
Albuterol to Improve Respiratory Strength in SCI |
- Spinal Cord Injury
- Respiratory Muscle Weakness
|
- Drug: Oral Albuterol Extended Release
- Drug: Placebo
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Respiratory Muscle Strength
|
24 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02508311 |
B1910-P
SCH-15-011 |
|
June 1, 2016 |
December 31, 2018 |
June 28, 2019 |
July 24, 2015 |
April 17, 2018 |
|
- James J. Peters VA Medical Center, Bronx, NY
Bronx, New York, United States
|
| 22 |
NCT02889146 |
Recruiting |
Progressive Mobility Program and Technology to Improve the Level of Physical Activity and Functionality of ICU Patients |
- Critical Illness
- Muscle Weakness
|
- Other: Conventional Physical Therapy
- Other: Early and progressive mobilization program
- Other: Respiratory therapy
|
Interventional |
Not Applicable |
- University of Sao Paulo General Hospital
- Fundação de Amparo à Pesquisa do Estado de São Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Functional status
- Level of physical activity during the whole intensive care unit stay
- Pulmonary function
- (and 9 more...)
|
98 |
All |
18 Years and older (Adult, Senior) |
NCT02889146 |
deborass |
|
February 1, 2017 |
August 2018 |
November 2018 |
September 5, 2016 |
March 19, 2018 |
|
- Department of Physiotherapy, Communication Science & Disorders, Occupational Therapy - Medical School of University of Sao Paulo
Sao Paulo, SP, Brazil
|
| 23 |
NCT01570816 |
Recruiting |
Improving Ambulatory Community Access After Paralysis |
- Stroke
- Partial Paralysis
- Spinal Cord Injury
- (and 2 more...)
|
- Device: IRS-8 (8 channel implanted receiver stimulator)
|
Interventional |
Phase 1 |
- Louis Stokes VA Medical Center
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The effect of functional electrical stimulation of the hip, knee and ankle muscles to improve walking in people with partial paralysis
- Feasibility of initiating a step with a trigger from an accelerometer incorporated in the external control unit to adjust to environmental circumstances and situations encountered in community ambulation
|
6 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT01570816 |
12004-H02
1I01RX000528-01A2 |
|
April 2012 |
July 2021 |
July 2021 |
April 4, 2012 |
March 14, 2018 |
|
- Louis Stokes Cleveland Dept. of Veterans Affairs Medical Center
Cleveland, Ohio, United States
|
| 24 |
NCT03453944 |
Recruiting |
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients |
- Mechanical Ventilation Complication
- Neuromuscular Electrical Stimulation
- Muscle Weakness
|
- Device: VentFree prototype (VF03-K) active stimulation
- Device: VentFree prototype (VF03-K) sham stimulation
|
Interventional |
Not Applicable |
- University Medical Center Nijmegen
- Liberate Medical
- VU University Medical Center
- Canisius-Wilhelmina Hospital
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Thickness of the abdominal wall muscles
- Thickness of the diaphragm
- Thickness of the rectus abdominis muscle
- (and 7 more...)
|
20 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT03453944 |
LM-RB-01 |
|
March 9, 2017 |
July 1, 2018 |
December 31, 2018 |
March 5, 2018 |
March 5, 2018 |
|
- UMC Nijmegen
Nijmegen, Gelderland, Netherlands - Canisius Wilhelmina Hospital
Nijmegen, Gelderland, Netherlands - VU University Medical Center
Amsterdam, Noord-Holland, Netherlands
|
| 25 |
NCT03473106 |
Not yet recruiting
New |
Effect of Tourniquet Use on Muscle Thigh Function. |
- Pneumatic Tourniquet
- Muscle Weakness
|
- Device: Pneumatic tourniquet use
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Postoperative muscle dysfunction
- Basal upper and lower extremity blood pressures
- Upper and lower extremity blood pressures after spinal anesthesia
- (and 8 more...)
|
30 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03473106 |
OAIC 919/17 |
|
March 2018 |
March 2019 |
March 2019 |
March 22, 2018 |
March 23, 2018 |
|
- Hospital Clínico Universidad de Chile
Santiago, Metropolitana, Chile
|
| 26 |
NCT02919085 |
Recruiting |
Effect of Critical Patients Mobilization on Respiratory and Peripheral Muscle Strength and Functional Capacity. |
- Intensive Care Unit Syndrome
- Muscle Weakness
|
- Procedure: Early ambulation
|
Interventional |
Not Applicable |
- Universidade Federal de Pernambuco
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Respiratory muscle strength
- Peripheral muscle strength
- Functional capacity
|
40 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02919085 |
01110031483 |
|
December 2016 |
October 2017 |
December 2017 |
September 29, 2016 |
June 6, 2017 |
|
- Real Hospital Português de Beneficência
Recife, Pernambuco, Brazil
|
| 27 |
NCT03200678 |
Not yet recruiting |
WEakness and Atrophy: isoKinetic With Surface Electromyography Assessment in ACL Surgery |
- Anterior Cruciate Ligament Injury
- Muscle Weakness
|
- Other: isokinetic assessment
|
Interventional |
Not Applicable |
- Direction Centrale du Service de Santé des Armées
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
80 |
All |
18 Years to 45 Years (Adult) |
NCT03200678 |
2017-A00301-52
2017RC01 |
WEAKNESS |
September 2017 |
September 2019 |
September 2019 |
June 27, 2017 |
July 11, 2017 |
|
- Hôpital d'Instruction des Armées Clermont-Tonnerre
Brest, France
|
| 28 |
NCT02839018 |
Recruiting |
Nutrient Pattern Analysis in Critically Ill Patients (NAChO) |
- Intensive Care Unit (ICU) Acquired Weakness (ICU - AW)
- Muscle Weakness
|
|
Observational |
|
- University Hospital Inselspital, Berne
- Nestec Ltd.
|
Other / Industry |
- Observational Model: Other
- Time Perspective: Prospective
|
- Differences in blood nutrient levels over time in patients with/without ICU-AW (i.e. "ICU-AW group" vs. "no-ICU-AW group". Primary comparison of interest is between day 14 vs. day 6.
- Differences in blood nutrient levels over time in patients in "sepsis group" vs. "CNS group". Primary comparison of interest is between day 14 vs. day 6.
- Differences in urine nutrient levels over time in patients with/ without ICU-AW (i.e. "ICU-AW group" vs. "no-ICU-AW group". Primary comparison of interest is between day 14 vs. day 6.
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02839018 |
NAChO |
NAChO |
January 2017 |
December 2018 |
February 2019 |
July 20, 2016 |
March 12, 2018 |
|
- Inselspital, Dept of Intensive Care Medicine
Bern, Switzerland
|
| 29 |
NCT02530723 |
Recruiting |
Functional Changes and Power Training in Older Women. |
- Sarcopenia
- Muscle Weakness
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Stair-climb power
- Change in 400-meter walk test
- Change in Short Physical Performance Battery
- Change in 30-second chair stand test
|
50 |
Female |
70 Years and older (Senior) |
NCT02530723 |
27773 |
F-POW |
August 2015 |
December 2017 |
December 2017 |
August 21, 2015 |
October 26, 2017 |
|
- Athletic Centre; 55 Harbord Street
Toronto, Ontario, Canada
|
| 30 |
NCT03292159 |
Not yet recruiting |
Transcutaneous Vagus Nerve Stimulation for Motor Recovery After Stroke |
- Stroke
- Upper Extremity Paresis
|
- Device: Active RAVANS concurrent with arm motor training
- Device: Inactive RAVANS concurrent with arm motor training
|
Interventional |
Phase 1
Phase 2 |
- Massachusetts General Hospital
- Dana Foundation, Spaulding Rehabilitation Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Upper extremity motor impairment
- Upper extremity motor function
- Grip force control
- (and 2 more...)
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03292159 |
2017P000129 |
|
April 15, 2018 |
January 2020 |
January 2020 |
September 25, 2017 |
March 21, 2018 |
|
|
| 31 |
NCT02208219 |
Recruiting |
Music Therapy to Restore Motor Deficits After Stroke |
|
- Behavioral: Music-supported Therapy
- Behavioral: home-based Music-supported Therapy
- Behavioral: Conventional treatment
|
Interventional |
Not Applicable |
- University of Barcelona
- Institució Catalana de Recerca i Estudis Avançats
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in the performance of movements with the paretic upper extremity assessed by the Action Research Arm Test (Carroll, 1965; Lyle, 1981).
- Motor function: Change in the functional use of the paretic upper extremity using the Arm Paresis Score Test (Wade et al., 1983)
- Motor function: Change in motor performance in the paretic upper extremity assessed by in the Box and Block Test (Mathiowetz et al., 1985)
- (and 19 more...)
|
120 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT02208219 |
CUB011995 |
NEUROMUSIC |
November 2013 |
May 2017 |
July 2017 |
August 5, 2014 |
October 28, 2016 |
|
- University of Barcelona; Hospitals del Mar i l'Esperança
Barcelona, Spain
|
| 32 |
NCT02348762 |
Recruiting |
Energetics and Function in Older Humans |
- Aging
- Erythrocyte Glutathione Deficiency
- Muscle Weakness
|
- Dietary Supplement: Cysteine (as n-acetylcysteine) and Glycine
|
Interventional |
Phase 1 |
- Baylor College of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Red blood cell concentrations of Glutathione measured by HPLC
|
20 |
All |
21 Years to 80 Years (Adult, Senior) |
NCT02348762 |
H-34686 Glutathione and Aging |
|
November 2014 |
December 2018 |
December 2018 |
January 28, 2015 |
January 26, 2018 |
|
- Baylor Metabolic Research Unit (MRU)
Houston, Texas, United States
|
| 33 |
NCT02174770 |
Recruiting |
Blood Flow Restriction Training in Rehabilitation Patients |
- Anterior Cruciate Ligament Reconstruction
- Volumetric Muscle Loss
- Chronic Thigh Muscle Weakness
- Knee Arthroscopy
|
- Other: Blood Flow Restriction (BFR) Training
- Other: Standard ACSM-guided strength training
|
Interventional |
Not Applicable |
- Brooke Army Medical Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
160 |
All |
18 Years to 65 Years (Adult) |
NCT02174770 |
395166
397709 |
|
July 2014 |
December 2017 |
December 2018 |
June 26, 2014 |
May 3, 2016 |
|
- Brooke Army Medical Center
Fort Sam Houston, Texas, United States - Center for the Intrepid
Fort Sam Houston, Texas, United States
|
| 34 |
NCT03252132 |
Recruiting |
Resistance Training in Patients With Diabetic Neuropathy |
- Diabetes Mellitus, Type 2
- Polyneuropathy Diabetes
- Diabetes Complications
- (and 3 more...)
|
- Other: 12-week resistance training
|
Interventional |
Not Applicable |
- Danish Pain Research Center
- Odense University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Intraepidermal nerve fiber density (IENFD)
- Muscle strength (isokinetic strength)
|
180 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT03252132 |
IDNC-DD2-MUSCLE |
|
August 10, 2017 |
December 31, 2018 |
June 1, 2019 |
August 17, 2017 |
August 17, 2017 |
|
- Danish Pain Research Center, Aarhus University Hospital
Aarhus, Denmark
|
| 35 |
NCT03062735 |
Recruiting |
Efficacy of Inspiratory Muscle Training on Elite Swimmers |
- Reactive Airways Dysfunction Syndrome (Disorder)
- Muscle Weakness
- Dyspnea
|
- Other: Inspiratory Muscle Training
- Other: Sham Inspiratory Muscle Training
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Swimming time trials performance
|
40 |
All |
14 Years to 40 Years (Child, Adult) |
NCT03062735 |
PEAKNORTE-01-0145-FEDER-000010 |
PEAK |
February 6, 2017 |
April 2017 |
May 2017 |
February 23, 2017 |
February 23, 2017 |
|
- Faculty of Medicine of Porto University
Porto, Portugal
|
| 36 |
NCT03457740 |
Recruiting |
Supplement Study: Strength, Testosterone, Sexual Function, Quality of Life |
- Muscular Weakness
- Sexual Behavior
- Quality of Life
|
- Dietary Supplement: Formula 1
- Dietary Supplement: Formula 2
- Dietary Supplement: Placebo
|
Interventional |
Not Applicable |
- Appalachian State University
- Purity Products
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Change in leg/back muscle strength
- Change in serum testosterone
- Change in sexual function
- (and 4 more...)
|
120 |
Male |
40 Years to 70 Years (Adult, Senior) |
NCT03457740 |
18-0038 |
|
February 5, 2018 |
March 23, 2018 |
March 30, 2018 |
March 8, 2018 |
March 8, 2018 |
|
- Appalachian State University Human Performance Lab, North Carolina Research Campus
Kannapolis, North Carolina, United States
|
| 37 |
NCT02778945 |
Recruiting |
Neuromuscular Blockade for Optimising Surgical Conditions During Spinal Surgery |
- Neuromuscular Block
- Orthopedic Disorder of Spine
- Muscle Weakness
|
- Drug: Rocuronium 0.9 mg/kg
- Drug: Rocuronium 0.6 mg/kg
|
Interventional |
Not Applicable |
- The Catholic University of Korea
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Diagnostic
|
- the operation time
- back muscle stiffness ( 1. Shear Wave Ultrasound Elastography(SWE) )
- back muscle stiffness (2.Mechanical Tension Weighing Scale (MTWS) of mechanical dynamometer)
|
66 |
All |
19 Years and older (Adult, Senior) |
NCT02778945 |
ANESTHA-NMB1 |
|
September 2016 |
September 2018 |
December 2018 |
May 20, 2016 |
March 6, 2018 |
|
- Yeouido St. Mary's Hospital
Seoul, Korea, Republic of
|
| 38 |
NCT02527551 |
Recruiting |
Efficacy of Deep Haptic Massage in Fibromyalgia : Preliminary Study |
|
|
Interventional |
Not Applicable |
- Centre Hospitalier Universitaire de Nice
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effectiveness measured by QIF (Questionnary Impact Fibromyalgia) score
- Effectiveness on pain measured by items 4 to 10 of QIF score
- Effectiveness on fatigue measured by items 4 to 10 of QIF score
- (and 3 more...)
|
20 |
Female |
18 Years to 65 Years (Adult) |
NCT02527551 |
15-AOI-06 |
FEM |
November 2015 |
April 2017 |
November 2017 |
August 19, 2015 |
May 4, 2016 |
|
|
| 39 |
NCT02509520 |
Recruiting |
Assessing The Effects of Exercise, Protein, and Electric Stimulation On Intensive Care Unit Patients Outcomes |
- Muscle Weakness
- Critical Illness
- Sarcopenia
|
- Dietary Supplement: MPR and High Protein Supplement (HPRO)
- Device: MPR and Neuromusc Electric Stimulation (NMES)
- Other: MPR and NMES and HPRO
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Muscle mass
- Global body strength
- Mobility status
- (and 5 more...)
|
60 |
All |
45 Years and older (Adult, Senior) |
NCT02509520 |
00056749 |
ExPrEs |
May 2015 |
July 2018 |
July 2018 |
July 28, 2015 |
December 6, 2017 |
|
- U of Maryland, Baltimore, Professional Schools IRB
Baltimore, Maryland, United States
|
| 40 |
NCT03049956 |
Recruiting |
OVEMP in Myasthenia |
- Myasthenia Gravis, Ocular
|
- Diagnostic Test: Ocular vestibular evoced myogenic potentials
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Primary Purpose: Diagnostic
|
- Decrement (as quantified in %) of repetitive 20 Hz ocular vestibular-evoked myogenic potentials (oVEMP)
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03049956 |
2016-01109 |
|
November 1, 2016 |
December 31, 2019 |
December 31, 2019 |
February 10, 2017 |
February 10, 2017 |
|
- University Hospital Zurich, Ophthalmology/Neurology Department
Zurich, Switzerland
|
| 41 |
NCT03196960 |
Recruiting |
Effects of Mobility Dose in Surgical Intensive Care Unit Patients |
- Sarcopenia
- Muscle Weakness
- Critical Illness
|
|
Observational |
|
- Massachusetts General Hospital
- Technische Universität München
- Università degli Studi di Brescia
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adverse Hospital Discharge Disposition
- Rectus Femoris Muscle Cross Sectional Area
- Mobility Dose as measured by the Mobilization Quantification Score (MQS)
- (and 13 more...)
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT03196960 |
2016P002045 |
MQS |
May 22, 2017 |
December 2018 |
December 2018 |
June 23, 2017 |
June 23, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Klinikum Rechts der Isar
Munich, Bavaria, Germany - Università degli Studi di Brescia
Brescia, Lombardy, Italy
|
| 42 |
NCT00390104 |
Recruiting |
Molecular Analysis of Patients With Neuromuscular Disease |
- Limb-girdle Muscular Dystrophy
- Duchenne Muscular Dystrophy
- Becker Muscular Dystrophy
- Facioscapulohumeral Muscular Dystrophy
|
|
Observational |
|
- Boston Children’s Hospital
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Family-Based
- Time Perspective: Prospective
|
|
1000 |
All |
up to 100 Years (Child, Adult, Senior) |
NCT00390104 |
03-12-205
5R01NS080929 |
|
January 2002 |
December 31, 2020 |
December 31, 2021 |
October 19, 2006 |
July 11, 2017 |
|
- Children's Hospital Boston
Boston, Massachusetts, United States
|
| 43 |
NCT03102294 |
Not yet recruiting |
Inspiratory Muscle Training in Chronic Thromboembolic Pulmonary Hypertension |
- Chronic Thromboembolic Pulmonary Hypertension
- Inspiratory Muscle Training
- Inspiratory Muscle Weakness
|
- Other: inspiratory muscle training
- Other: Placebo "training"
|
Interventional |
Not Applicable |
- Federal University of São Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- exercise capacity¨- cardiopulmonary exercise testing
- exercise capacity - 6-min walk test
- ventilatory responses
- peripheral oxygenation
|
32 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03102294 |
FUSaoPaulo2017 |
|
September 1, 2017 |
November 30, 2018 |
April 30, 2019 |
April 5, 2017 |
August 7, 2017 |
|
- SEFICE - Setor de Função Pulmonar e Fisiologia Clínica do Exercício
Sao Paulo, São Paul, Brazil
|
| 44 |
NCT02880735 |
Recruiting |
Ventilatory Response After Non Invasive Ventilation in Type 1 Myotonic Dystrophy |
- Myotonic Dystrophy 1
- Steinert Disease
|
- Device: Non Invasive Ventilation.
|
Interventional |
Not Applicable |
- National Institute of Respiratory Diseases, Mexico
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilatory Response to Chemical Stimuli
- Health Related Quality of Life Measured by Short Form 36 (SF-36)
- Dyspnoea evaluated by the modified scale of the Medical Research Council (mMRC)
- Sleep Quality assessed by The Pittsburgh Sleep Quality Index (PSQI)
|
27 |
All |
18 Years and older (Adult, Senior) |
NCT02880735 |
C46-15 |
|
September 2016 |
April 2018 |
June 2018 |
August 26, 2016 |
September 14, 2016 |
|
- National Institute Of Respiratory Diseases
Mexico, Mexico
|
| 45 |
NCT01769846 |
Recruiting |
The Impact of Early Mobilization Protocol in Patients in the ICU |
- Muscle Weakness
- Quality of Life
- Weaning Acceleration
- (and 2 more...)
|
- Other: Early mobilization protocol
|
Interventional |
Not Applicable |
- Universidade Federal de Santa Maria
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Muscle thickness (MT) of the quadriceps femoris.
- Muscle thickness (MT) of the diaphragm.
- Rectus femoris cross-sectional area
- (and 11 more...)
|
28 |
All |
18 Years and older (Adult, Senior) |
NCT01769846 |
07201712.8.0000.5346 |
|
March 2015 |
September 2018 |
September 2018 |
January 17, 2013 |
March 12, 2018 |
|
- University Hospital of Santa Maria
Santa Maria, Rio Grande Do Sul, Brazil
|
| 46 |
NCT03055182 |
Recruiting |
Oxygenation of Paravertebral Muscles During Exercise in Chronic Low Back Pain Patients |
- Low Back Pain
- Rehabilitation Program
- Muscular Weakness
|
- Other: Physical rehabilitation program
|
Interventional |
Not Applicable |
- University Hospital, Lille
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Deoxyhemoglobin
- Oxygen consumption
- Work rate
- (and 4 more...)
|
36 |
All |
20 Years to 60 Years (Adult) |
NCT03055182 |
2015_58
2016-A01151-50 |
OXYLOM |
January 2017 |
December 2019 |
December 2019 |
February 16, 2017 |
November 9, 2017 |
|
- Hôpital Swyngedhauw, CHRU
Lille, France
|
| 47 |
NCT02012933 |
Available |
3,4-Diaminopyridine for Lambert-Eaton Myasthenic Syndrome (LEMS) and Congenital Myasthenia (CM) |
- Lambert-Eaton Myasthenic Syndrome (LEMS)
- Congenital Myasthenia (CM)
|
- Drug: 3,4-diaminopyridine
|
Expanded Access |
|
- Tessa L Marburger
- Jacobus Pharmaceutical
- Oregon Health and Science University
|
Other / Industry |
|
|
|
All |
2 Years and older (Child, Adult, Senior) |
NCT02012933 |
Jacobus compassionate program |
|
|
|
|
December 17, 2013 |
April 21, 2015 |
|
- Oregon Health & Science University
Portland, Oregon, United States
|
| 48 |
NCT03452254 |
Not yet recruiting |
NIBS With mCIMT for Motor and Functional Upper Limb Recovery in Stroke Patients. |
- Stroke
- Upper Extremity Paresis
- Electric Stimulation
- Occupational Therapy
|
- Device: Active Bihemispheric Transcranial direct current Stimulation
- Device: Sham Bihemispheric Transcranial direct current Stimulation
- Other: Modified Constraint Induced Movement Therapy
|
Interventional |
Not Applicable |
- University of Chile
- Comisión Nacional de Investigación Científica y Tecnológica
- Hospital Clínico Universidad de Chile
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Upper Limb Motor Recovery.
- Upper Limb Functional Recovery.
- Independence in basic activities of daily living.
- Brain activation patterns.
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT03452254 |
849/16 |
|
April 2, 2018 |
March 30, 2020 |
June 30, 2020 |
March 2, 2018 |
March 12, 2018 |
|
|
| 49 |
NCT02739464 |
Recruiting |
Effect of In-Patient Exercise Training on Length of Hospitalization in Burned Patients |
- Muscle Weakness
- Late Effect of Burn
- Muscle; Fatigue, Heart
- Burn Rehabilitation
|
- Other: Exercise + SOC PT/OT
- Other: Standard of Care PT/OT
|
Interventional |
Not Applicable |
- The University of Texas Medical Branch, Galveston
- United States Army Institute of Surgical Research
- University of Texas Southwestern Medical Center
- California State University, Sacramento
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Dual X-ray Absorptiometry (DEXA)
- Peak VO2 treadmill test
- Six minute Walk test
|
96 |
All |
7 Years to 60 Years (Child, Adult) |
NCT02739464 |
SHC; IRB #14-0432 |
MP-10 |
July 2015 |
December 2018 |
December 2019 |
April 15, 2016 |
July 2, 2017 |
|
- University of California-Davis/Shriners Hospitals for Children-Sacramento
Davis, California, United States - University of Texas Southwestern Medical Center
Dallas, Texas, United States - University of Texas Medical Branch/Shriners Hospitals for Children-Galveston (lead site)
Galveston, Texas, United States - United States Army Institute of Surgical Research
San Antonio, Texas, United States
|
| 50 |
NCT01734369 |
Recruiting |
Environmental Risk Factors for Myositis in Military Personnel |
- Dermatomyositis
- Adult Polymyositis
- Inclusion Body Myositis
- Myositis
|
|
Observational |
|
- National Institute of Environmental Health Sciences (NIEHS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Other
|
- Military Myositis Questionnaire
|
300 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT01734369 |
130015
13-E-0015 |
|
November 22, 2012 |
September 30, 2018 |
September 30, 2019 |
November 27, 2012 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
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