1 |
NCT02153983 |
Recruiting |
Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome |
|
- Drug: Colchicine 0.6 mg given
- Drug: Placebo capsules given
|
Interventional |
Phase 1 Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in insulin sensitivity
- Change in metabolic parameters
- Changes in other inflammatory markers
|
250 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02153983 |
140119 14-CH-0119 |
|
May 31, 2014 |
June 29, 2018 |
December 31, 2018 |
June 3, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
2 |
NCT02633891 |
Recruiting |
Metabolic Syndrome and Fall Risk |
- Metabolic Syndrome
- Autonomic Neuropathy
|
- Behavioral: Balance exercise
- Behavioral: Standard care
|
Interventional |
Not Applicable |
- VA Office of Research and Development
- University of Maryland
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Four Square Step Test (FSST)
- Dynamic Gait Index (DGI)
|
55 |
All |
50 Years to 70 Years (Adult, Senior) |
NCT02633891 |
F1651-W 1IK2RX001651-01A2 |
|
January 2, 2017 |
July 1, 2020 |
December 31, 2020 |
December 17, 2015 |
February 5, 2018 |
|
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States
|
3 |
NCT03489109 |
Recruiting New |
2-5 Intermittent Caloric Restriction for Weight Loss and Insulin Resistance in HIV-Infected Adults With Features of the Metabolic Syndrome |
- Human Immunodeficiency Virus
- Metabolic Syndrome
|
- Behavioral: Intermittent fasting
- Behavioral: Standard of Care
|
Interventional |
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in weight and insulin sensitivity as measured by HOMA-IR
- Tolerability of ICR
- Change in lipid levels, metabolic biomarkers, biomarkers of inflammation and immune activation, and mood.
- Change in body composition, including visceral adiposity abd hepatic steatosis.
|
100 |
All |
18 Years to 65 Years (Adult) |
NCT03489109 |
180075 18-I-0075 |
|
April 26, 2018 |
January 31, 2022 |
January 31, 2022 |
April 5, 2018 |
April 23, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
4 |
NCT03170375 |
Not yet recruiting |
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome |
|
- Behavioral: Performance of WHEELS-I in promoting DASH/SRD adoption
- Behavioral: Effects of a 2-week DASH/SRD intervention vs. control diet on HFpEF functional cardiovascular risk factors
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Carotid-femoral pulse wave velocity
- Left ventricular mass index
- Ventricular stiffness
- (and 3 more...)
|
130 |
All |
45 Years and older (Adult, Senior) |
NCT03170375 |
CARA-009-16F 9050 |
|
June 4, 2018 |
December 30, 2022 |
December 30, 2022 |
May 31, 2017 |
February 26, 2018 |
|
- VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States
|
5 |
NCT03355469 |
Recruiting |
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome |
|
- Combination Product: LoEx+Metformin
- Combination Product: HiEx+Metformin
- Combination Product: LoEx+Placebo
- Combination Product: HiEx+Placebo
|
Interventional |
Phase 4 |
- University of Virginia
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Flow Mediated Dilation of brachial artery
- Change in Metabolic Insulin Sensitivity by the Euglycemic Clamp
- Change in Post Ischemic Flow Velocity in brachial artery
- (and 4 more...)
|
80 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT03355469 |
19364 1R01HL130296-01A1 |
|
August 7, 2017 |
June 30, 2021 |
January 31, 2022 |
November 28, 2017 |
November 28, 2017 |
|
- University of Virginia
Charlottesville, Virginia, United States
|
6 |
NCT02204709 |
Recruiting |
Disease Risk Reduction and Omega-3 Rich Rainbow Trout (Fish for Health) |
|
- Other: 2N Trout
- Other: 3N Trout
- Other: Tilapia
|
Interventional |
Not Applicable |
- USDA Grand Forks Human Nutrition Research Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Change from baseline in platelet activation at week 6 of each treatment
- Change from baseline in plasma interleukin-6 (IL-6) at week 6 of each treatment
- Change from baseline in plasma tumor necrosis factor alpha (TNFa) at week 6 of each treatment
- (and 6 more...)
|
43 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT02204709 |
GFHNRC029 |
|
June 2015 |
September 2018 |
December 2019 |
July 30, 2014 |
March 19, 2018 |
|
- USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States
|
7 |
NCT02124512 |
Recruiting |
Blood Lipopolysaccharide (LPS) Rifaximin Study |
- Obese
- Insulin Resistance
- Metabolic Syndrome
|
- Drug: Rifaximin SSD
- Other: Placebo
|
Interventional |
Phase 2 |
- Philip Kern
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Decrease in circulating LPS
- Decrease in tissue inflammation
|
40 |
All |
35 Years to 65 Years (Adult) |
NCT02124512 |
14-0136-F1V UL1TR000117 1R21DK100258-01A1 |
|
March 2015 |
May 31, 2018 |
June 2018 |
April 28, 2014 |
January 19, 2018 |
|
- University of Kentucky Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
8 |
NCT03418857 |
Not yet recruiting |
Probiotics and Gut Health |
|
- Drug: Yogurt smoothie with BB-12
- Drug: Yogurt smoothie
|
Interventional |
Phase 1 Phase 2 |
- Penn State University
- United States Department of Agriculture (USDA)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Change from baseline in inflammatory markers
- Change in number and activation of leukocytes
- Change in gut permeability
- (and 2 more...)
|
40 |
All |
55 Years to 75 Years (Adult, Senior) |
NCT03418857 |
STUDY0006843 |
PRO |
May 2018 |
December 2018 |
December 2019 |
February 1, 2018 |
April 19, 2018 |
|
- The Pennsylvania State University
University Park, Pennsylvania, United States
|
9 |
NCT00815854 |
Recruiting |
Examining Risk Factors for Atypical Antipsychotic Metabolic Side Effects |
|
- Dietary Supplement: Folic Acid
- Other: Placebo
|
Interventional |
Not Applicable |
- University of Michigan
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Other
|
- Endothelial functioning
- metabolic syndrome
|
150 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT00815854 |
R01MH082784 R01MH082784-01 DATR A5-ETSE |
|
October 2008 |
September 2018 |
September 2018 |
December 31, 2008 |
April 28, 2017 |
|
- University of Michigan
Ann Arbor, Michigan, United States
|
10 |
NCT02252081 |
Recruiting |
Metformin in Kidney Disease |
- Chronic Kidney Disease
- Cardiovascular Disease
- Metabolic Syndrome
|
- Drug: metformin
- Drug: Placebo
|
Interventional |
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- leptin to adiponectin ratio (LAR)
- estimated glomerular filtration rate (eGFR)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02252081 |
ENDA-014-13F 1I01CX000982-01A1 |
|
October 1, 2014 |
December 31, 2019 |
December 31, 2019 |
September 29, 2014 |
January 19, 2018 |
|
- Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States
|
11 |
NCT02919176 |
Recruiting |
Brown Fat Activation Study |
|
- Drug: Mirabegron
- Drug: Pioglitazone
- Drug: Mirabegron and Pioglitazone
|
Interventional |
Early Phase 1 |
- Philip Kern
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in beige adipose tissue
- Change in brown adipose tissue
- Change in insulin sensitivity
- (and 2 more...)
|
75 |
All |
35 Years to 65 Years (Adult) |
NCT02919176 |
16-0642-F1V |
|
September 1, 2016 |
December 1, 2019 |
December 1, 2020 |
September 29, 2016 |
May 25, 2017 |
|
- Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
12 |
NCT02470260 |
Recruiting |
Northern Manhattan Study of Metabolism and Mind |
- Diabetes
- Pre-diabetes
- Cognition - Other
- (and 2 more...)
|
|
Observational |
|
- Columbia University
- National Institute on Minority Health and Health Disparities (NIMHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Cognition
- Transitions in diabetes status
- Metabolic syndrome
- Depressive symptoms
|
1000 |
All |
50 Years to 64 Years (Adult) |
NCT02470260 |
AAAI5156 P60MD000206 |
NOMEM |
January 2012 |
December 2020 |
December 2020 |
June 12, 2015 |
September 15, 2015 |
|
- Columbia University Medical Center
New York, New York, United States
|
13 |
NCT03229057 |
Recruiting |
Comparing the Effects of Oral Contraceptive Pills Versus Metformin |
|
- Drug: OCP + Metformin
- Drug: OCP + Placebo
- Drug: Metformin + Placebo
|
Interventional |
Phase 3 |
- University of Pennsylvania
- Milton S. Hershey Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Prevalence of metabolic syndrome after randomizing to low dose OCP, metformin or OCP+metformin for 6 months.
- Change in HDL-C function
- Changes in serum apoliproteins
- (and 5 more...)
|
240 |
Female |
18 Years to 40 Years (Adult) |
NCT03229057 |
827819 |
COMET-PCOS |
January 1, 2018 |
April 30, 2021 |
April 30, 2022 |
July 25, 2017 |
January 30, 2018 |
|
- University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
14 |
NCT01797302 |
Recruiting |
Vitamin D and Vascular Health in Children |
- Obesity
- Vitamin D Deficiency
|
- Dietary Supplement: Vitamin D3
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Heart, Lung, and Blood Institute (NHLBI)
- Office of Dietary Supplements (ODS)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- brachial artery flow-mediated dilation (FMD)
- pulse-wave velocity (PWV)
- fasting glucose/fasting insulin ratio
|
252 |
All |
10 Years to 18 Years (Child, Adult) |
NCT01797302 |
PRO12100034 R01HL112985 5R01HL112985-05 |
|
August 2013 |
January 31, 2019 |
January 31, 2019 |
February 22, 2013 |
February 5, 2018 |
|
- Primary Care Center, Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, United States
|
15 |
NCT02596776 |
Recruiting |
Cold Induced Changes in White Adipose |
- Obese
- Normal Body Weight
- Prediabetes
- Metabolic Syndrome
|
- Procedure: Fat biopsy
- Drug: Propranolol and fat biopsy
- Other: heavy water and fat biopsy
|
Interventional |
Early Phase 1 |
- Philip Kern
- National Institutes of Health (NIH)
- University of Kentucky
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- WAT changes during repeated exposure to cold temperatures
- WAT changes following Propranolol dosing
- In vivo measurement of adipose lipolysis and triglyceride (TG) turnover
|
90 |
Female |
35 Years to 60 Years (Adult) |
NCT02596776 |
15-0663 |
|
March 2016 |
December 2019 |
December 2019 |
November 4, 2015 |
May 8, 2017 |
|
- University of Kentucky Medical Center Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
16 |
NCT00085982 |
Recruiting |
Effect of Leptin Therapy in the Treatment of Severe Insulin Resistance |
|
|
Interventional |
Phase 2 |
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
- Improvements in HbA1c, fasting blood glucose, and fasting insulin levels, as well as the glucose and insulin responses to glucose tolerance tests and insulin tolerance tests.
|
20 |
All |
5 Years and older (Child, Adult, Senior) |
NCT00085982 |
030257 03-DK-0257 |
|
July 28, 2003 |
January 1, 2030 |
January 1, 2030 |
June 21, 2004 |
April 6, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
17 |
NCT02520609 |
Recruiting |
Dynamic Post-Prandial Metabolism in Patients With Non-Alcoholic Fatty Liver Disease |
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Change in metabolomics readout from baseline
|
74 |
All |
18 Years and older (Adult, Senior) |
NCT02520609 |
150174 15-DK-0174 |
|
August 8, 2015 |
December 31, 2018 |
December 31, 2018 |
August 13, 2015 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
18 |
NCT02363309 |
Recruiting |
Palmitate Breath Test to Assess Fatty Acid Oxidation in Non Alcoholic Fatty Liver Disease (NAFLD) |
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Apply PBT (with ABT correction) to measure rates of fatty acid oxidation in patients with non alcoholic fatty liver disease
- Compare rates of fatty acid oxidation between healthy controls and patients with fatty liver disease
- Determine the effect of NAFLD interventions on rates of fatty acid oxidation and asses association of findings with disease severity and metabolic features
|
120 |
All |
21 Years and older (Adult, Senior) |
NCT02363309 |
150080 15-DK-0080 |
|
February 13, 2015 |
January 31, 2019 |
January 31, 2020 |
February 16, 2015 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
19 |
NCT02244814 |
Recruiting |
Trial of Diet in Gestational Diabetes Mellitus: Metabolic Consequences to Mother and Offspring |
- Gestational Diabetes Mellitus
|
- Behavioral: Low Carbohydrate/Conventional
- Behavioral: Choosing Healthy Options in Carbohydrate Energy
|
Interventional |
Not Applicable |
- University of Colorado, Denver
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Neonatal adiposity
- Maternal Insulin Resistance
- Placental fatty acid transporter protein-2 expression
|
148 |
All |
up to 36 Years (Child, Adult) |
NCT02244814 |
14-1358 |
CHOICE |
April 2015 |
June 2019 |
December 2019 |
September 19, 2014 |
December 7, 2016 |
|
- University of Colorado/Anschutz Medical Campus
Aurora, Colorado, United States
|
20 |
NCT02537548 |
Recruiting |
Retroperitoneal Lymph Node Dissection in Treating Patients With Testicular Seminoma |
- Lymphadenopathy
- Stage I Testicular Seminoma
- Stage II Testicular Seminoma
|
- Other: Laboratory Biomarker Analysis
- Procedure: Retroperitoneal Lymph Node Dissection
|
Interventional |
Not Applicable |
- University of Southern California
- National Cancer Institute (NCI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- RFS
- Long-term RPLND complication rates
- Short-term RPLND complication rates
|
46 |
Male |
16 Years and older (Child, Adult, Senior) |
NCT02537548 |
4T-14-1 NCI-2015-01177 HS-15-00246 P30CA014089 |
|
August 28, 2015 |
August 28, 2019 |
August 28, 2020 |
September 1, 2015 |
December 12, 2017 |
|
- Loma Linda University Medical Center
Loma Linda, California, United States - USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States - University of California, San Francisco
San Francisco, California, United States - (and 8 more...)
|
21 |
NCT02133885 |
Recruiting |
Study 2: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients |
|
- Drug: Minocycline Group
- Other: Placebo Group
|
Interventional |
Phase 1 Phase 2 |
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Reduction of ambulatory blood pressure
|
101 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02133885 |
IRB201500594-N RO1HL3361028 2013-00102 Study 2 R01HL132448-01 |
|
December 2016 |
May 2018 |
May 2018 |
May 8, 2014 |
April 5, 2018 |
|
- UF Health Cardiovascular Clinic
Gainesville, Florida, United States
|
22 |
NCT02622295 |
Recruiting |
Musculoskeletal Plasticity After Spinal Cord Injury |
|
- Behavioral: Single-session high-frequency active-resisted stance
- Behavioral: Single-session low-frequency active-resisted stance
- Behavioral: High-frequency active-resisted stance training
- Behavioral: Low-frequency active-resisted stance training
|
Interventional |
Not Applicable |
- Richard K Shields
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- University of Iowa
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Acute gene regulation: MSTN
- Acute gene regulation: PGC1-alpha
- Acute gene regulation: PDK4
- (and 10 more...)
|
80 |
All |
21 Years to 60 Years (Adult) |
NCT02622295 |
200412709 R01HD084645 |
|
May 2015 |
January 2020 |
January 2020 |
December 4, 2015 |
November 29, 2017 |
|
- University of Iowa
Iowa City, Iowa, United States
|
23 |
NCT02133872 |
Recruiting |
Study 1: Effect of Minocycline Treatment on Drug-Resistant Hypertensive Patients |
|
- Drug: Minocycline 100mg Group
- Drug: Minocycline 200mg Group
|
Interventional |
Phase 1 |
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in High Blood Pressure
- Renal function changes
|
175 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02133872 |
2013-00102 Study 1-N RO1HL3361028 |
|
October 2014 |
August 2018 |
August 2018 |
May 8, 2014 |
April 5, 2018 |
|
- UF Health Cardiovascular Clinic
Gainesville, Florida, United States
|
24 |
NCT03139344 |
Recruiting |
Long Duration Activity and Metabolic Control After Spinal Cord Injury |
|
- Other: Low-frequency Exercise
- Other: High-frequency Exercise
|
Interventional |
Not Applicable |
- University of Iowa
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Acute gene regulation: NR4A3
- Acute gene regulation: PGC1-alpha
- Acute gene regulation: ABRA
- (and 9 more...)
|
96 |
All |
18 Years and older (Adult, Senior) |
NCT03139344 |
201503732 R01HD082109 |
|
August 1, 2015 |
April 2020 |
April 2020 |
May 3, 2017 |
May 3, 2017 |
|
- University of Iowa
Iowa City, Iowa, United States
|
25 |
NCT03495986 |
Not yet recruiting New |
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement |
- Spinal Cord Injuries
- Metabolic Syndrome
- Dietary Modification
- (and 2 more...)
|
- Device: Functional Electrical Stimulation Leg Cycle Ergometry
- Behavioral: Diet
|
Interventional |
Not Applicable |
- Milton S. Hershey Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percent Body fat
- Fat Mass and Fat-Free Mass
- Insulin Sensitivity (Si)
- (and 5 more...)
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT03495986 |
6996 R01HD091278-01 |
SCIENCE |
April 2018 |
April 2022 |
July 2022 |
April 12, 2018 |
April 12, 2018 |
|
- Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
26 |
NCT03414385 |
Not yet recruiting |
Effect of Exercise on Genes That Control Muscle Function |
|
|
Interventional |
Not Applicable |
- Baylor College of Medicine
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- Veterans Affairs
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in JunD/AP-1 signaling in human skeletal muscle
|
30 |
All |
20 Years to 40 Years (Adult) |
NCT03414385 |
H-40366 1R01DK111436-01A1 |
|
February 1, 2018 |
December 31, 2022 |
December 31, 2022 |
January 29, 2018 |
January 29, 2018 |
|
- Baylor College of Medicine/Michael E DeBakey VA Medical Center
Houston, Texas, United States
|
27 |
NCT02878798 |
Recruiting |
Topiramate for Cryptogenic Sensory Peripheral Neuropathy |
- Cryptogenic Sensory Peripheral Neuropathy
|
- Drug: topiramate
- Other: Placebo
|
Interventional |
Phase 2 |
- University of Utah
- National Institute of Neurological Disorders and Stroke (NINDS)
- NeuroNEXT Network
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Intraepidermal nerve fiber density (IENFD)
- Norfolk Quality of Life - Diabetic Neuropathy
- Nerve conduction studies
- (and 5 more...)
|
125 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02878798 |
URNN001 |
TopCSPN |
February 12, 2018 |
March 2019 |
December 2021 |
August 25, 2016 |
April 10, 2018 |
|
- University of Alabama Birmingham
Birmingham, Alabama, United States - University of Colorado Denver
Aurora, Colorado, United States - University of Miami
Miami, Florida, United States - (and 12 more...)
|
28 |
NCT03440229 |
Recruiting |
Functional Research of Emulsifiers in Humans |
|
- Other: Emulsifier-containing diet
|
Interventional |
Not Applicable |
- University of Pennsylvania
- Georgia State University
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Distance of nearest bacteria to the epithelium
- Change in weight
- Area under glucose concentration curve
- (and 3 more...)
|
16 |
All |
18 Years to 60 Years (Adult) |
NCT03440229 |
828422 R21DK115180 |
FRESH |
April 6, 2018 |
September 2019 |
September 2019 |
February 21, 2018 |
April 17, 2018 |
|
- Hospital of the University of Pennsylvania
Philadelphia, Pennsylvania, United States
|
29 |
NCT03284346 |
Recruiting |
Exercise in Targeting Metabolic Dysregulation in Stage I-III Breast or Prostate Cancer Survivors |
- Cancer Survivor
- No Evidence of Disease
- Obesity
- (and 13 more...)
|
- Behavioral: Exercise Intervention
- Other: Laboratory Biomarker Analysis
- Device: Monitoring Device
- (and 2 more...)
|
Interventional |
Not Applicable |
- University of Southern California
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in insulin resistance
- Change in metabolic syndrome (Blood Pressure)
- Change in metabolic syndrome (Waist Circumference)
- (and 3 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03284346 |
0S-17-5 NCI-2017-01426 P30CA014089 |
|
August 17, 2017 |
August 17, 2020 |
August 17, 2021 |
September 15, 2017 |
September 15, 2017 |
|
- USC / Norris Comprehensive Cancer Center
Los Angeles, California, United States
|
30 |
NCT02367105 |
Recruiting |
Lifestyle Intervention and Testosterone Replacement in Obese Seniors |
|
- Drug: Testosterone
- Other: Lifestyle Therapy
- Drug: Placebo
|
Interventional |
Phase 3 |
- VA Office of Research and Development
- Biomedical Research Institute of New Mexico
- Washington University School of Medicine
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Objective physical performance test
- Fat free mass
- Fat mass
- (and 38 more...)
|
72 |
Male |
65 Years to 85 Years (Adult, Senior) |
NCT02367105 |
ENDA-034-12F CX000906 |
LITROS |
February 1, 2015 |
December 31, 2018 |
December 31, 2018 |
February 20, 2015 |
February 5, 2018 |
|
- Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States
|
31 |
NCT02750826 |
Recruiting |
Breast Cancer WEight Loss Study (BWEL Study) |
|
- Other: Health Education Program
- Other: Weight Loss Intervention
|
Interventional |
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
- Division of Cancer Control
- NIH Biomarker, Imaging and Quality of Life Studies Funding Program (BIQSFP)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Invasive disease-free survival
- Overall survival
- Distant disease-free survival
- (and 20 more...)
|
3136 |
Female |
18 Years and older (Adult, Senior) |
NCT02750826 |
A011401 NCI-2015-01918 |
|
August 2016 |
May 2030 |
|
April 26, 2016 |
April 9, 2018 |
|
- Anchorage Associates in Radiation Medicine
Anchorage, Alaska, United States - Anchorage Radiation Therapy Center
Anchorage, Alaska, United States - Alaska Breast Care and Surgery LLC
Anchorage, Alaska, United States - (and 1259 more...)
|
32 |
NCT00406445 |
Recruiting |
Role of p53 Gene in Metabolism Regulation in Patients With Li-Fraumeni Syndrome |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Non-invasively measure aerobic exercise capacity and metabolism
- Non-invasively measure markers of mitochondrial function by magnetic resonance spectroscopy (MRS) in response to transient ischemic stress
- Measure oxygen consumption, protein and RNA levels of p53-regulated mitochondrial genes using blood cells and other tissue samples if available.
|
226 |
All |
18 Years and older (Adult, Senior) |
NCT00406445 |
070030 07-H-0030 |
|
November 24, 2006 |
|
|
December 4, 2006 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
33 |
NCT03229408 |
Not yet recruiting |
Treating Inflammation in Polycystic Ovary Syndrome to Ameliorate Ovarian Dysfunction |
- Polycystic Ovary Syndrome
|
- Drug: Salsalate
- Other: Placebo
|
Interventional |
Phase 2 |
- University of Illinois at Chicago
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Aim 1: Area under the curve (AUC) for circulating testosterone from serial measurements during HCG stimulation test
- Aim 2: Maximum lipid-stimulated mononuclear cell nuclear factor ĸB activation during cream challenge test
- Aim1: Whole body glucose disposal during euglycemic first phase of pancreatic clamp
- (and 2 more...)
|
90 |
Female |
18 Years to 40 Years (Adult) |
NCT03229408 |
UIC-PCOS-0617 R01DK107605-01 |
TIN-PCOS-AOD |
January 2018 |
August 31, 2021 |
August 31, 2021 |
July 25, 2017 |
October 31, 2017 |
|
|
34 |
NCT02842281 |
Recruiting |
Microbiome Fructan Metabolism and Symptoms in Childhood IBS |
- Irritable Bowel Syndrome (IBS)
|
- Other: Fructan
- Other: Maltodextrin
|
Interventional |
Not Applicable |
- Baylor College of Medicine
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Other
|
- Operational Taxonomic Units (microbiome composition derived from 16s rRNA sequencing)
- Microbiome metabolic signatures related to fructan metabolism
- Metabolic products of fructan metabolism
- (and 4 more...)
|
80 |
All |
7 Years to 17 Years (Child) |
NCT02842281 |
H-34372 K23DK101688 |
|
September 2014 |
March 2019 |
December 2019 |
July 22, 2016 |
August 2, 2017 |
|
- Children's Nutrition Research Center
Houston, Texas, United States - Texas Children's Hospital
Houston, Texas, United States
|
35 |
NCT02896452 |
Recruiting |
Astronaut Vision Issues in a Ground Analog Population: Polycystic Ovary Syndrome |
- Polycystic Ovarian Syndrome
- Idiopathic Intracranial Hypertension
|
|
Observational |
|
- National Aeronautics and Space Administration (NASA)
- University of Texas
- Mayo Clinic
- (and 3 more...)
|
U.S. Fed / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Single Nucleotide Polymorphism (SNP) Genetic Testing related to 1-Carbon Metabolism Pathway for 523 SNPs
- Ophthalmologic exam -OCT
- Ophthalmologic exam -Fundus
- (and 12 more...)
|
80 |
Female |
18 Years to 50 Years (Adult) |
NCT02896452 |
NASA |
PCOS |
October 1, 2016 |
April 2018 |
November 2019 |
September 12, 2016 |
April 11, 2017 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
36 |
NCT00001721 |
Recruiting |
Study of Smith-Lemli-Opitz Syndrome |
- Abnormalities
- Inborn Errors of Metabolism
- Mental Retardation
- (and 2 more...)
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
200 |
All |
Child, Adult, Senior |
NCT00001721 |
980081 98-CH-0081 |
|
March 23, 1998 |
|
|
November 4, 1999 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
37 |
NCT02919956 |
Recruiting |
Cerebral Anatomy, Hemodynamics and Metabolism |
- Hypoplastic Left Heart Syndrome
|
- Other: Magnetic Resonance Imaging
- Other: Neurodevelopmental Testing
|
Observational |
|
- Children's Hospital of Philadelphia
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Relationship of CBF and Brain Abnormalities to ND Outcomes
- Relationship of CMRO2 to ND outcome
|
150 |
All |
Child, Adult, Senior |
NCT02919956 |
15-012291 5R01HL090615-07 |
|
April 2016 |
June 2019 |
June 2019 |
September 30, 2016 |
October 3, 2017 |
|
- Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
|
38 |
NCT02769949 |
Recruiting |
Pediatric Patients With Metabolic or Other Genetic Disorders |
- Genetic Disorder
- Asperger Disorder
- Autism Spectrum Disorder
- (and 2 more...)
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Other
|
- Recruit Patients with Suspected or Siagnosed genetic diseases
|
5000 |
All |
Child, Adult, Senior |
NCT02769949 |
160103 16-CH-0103 |
|
May 11, 2016 |
December 31, 2036 |
December 31, 2036 |
May 12, 2016 |
April 11, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
39 |
NCT02841553 |
Recruiting |
Wolfram Syndrome International Registry and Clinical Study |
- Wolfram Syndrome
- Diabetes Mellitus
- Optic Nerve Atrophy
- (and 3 more...)
|
|
Observational |
|
- Washington University School of Medicine
- American Diabetes Association
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Changes in C-peptide levels in participants
- Changes in best-corrected visual acuity in participants measured by Snellen optotype
|
200 |
All |
1 Year to 80 Years (Child, Adult, Senior) |
NCT02841553 |
201107067 UL1TR000448 |
|
July 2011 |
December 2020 |
December 2020 |
July 22, 2016 |
November 6, 2017 |
|
- Washington University School of Medicine
Saint Louis, Missouri, United States
|