| 1 |
NCT03042598 |
Recruiting |
Biphasic Ventilation Airway Management Clinical Trial |
|
- Device: Biphasic Cuirass Ventilation
|
Interventional |
Not Applicable |
- University Medical Center of Southern Nevada
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Composite Primary Endpoint is the composite prevalence of any desaturation defined as SPO2 < 95% or Bradycardia, HR <60 beats per minute sustained for at least 30 seconds
- Prevalence of post-paralytic Bag valve mask use
- Waveform capnography pattern
- (and 3 more...)
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03042598 |
EM 2016.05 |
BVAM |
January 14, 2017 |
April 2017 |
April 2017 |
February 3, 2017 |
February 3, 2017 |
|
- University Medical Center of Southern Nevada
Las Vegas, Nevada, United States
|
| 2 |
NCT03114384 |
Recruiting |
Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography |
|
- Other: Creation and detection of patient-respirator asynchronies
|
Interventional |
Not Applicable |
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Asynchronies detection with diaphragm ultrasonography
|
15 |
All |
18 Years and older (Adult, Senior) |
NCT03114384 |
2017-A00346-47 |
ADULT |
April 14, 2017 |
July 30, 2017 |
July 30, 2017 |
April 14, 2017 |
April 14, 2017 |
|
- Groupe Hospitalier Henri Mondor
Creteil, France
|
| 3 |
NCT03464071 |
Not yet recruiting |
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation |
|
- Device: Hyperinflation with mechanical ventilator
- Device: Manual hyperinflation
|
Interventional |
Not Applicable |
- Hospital de Clinicas de Porto Alegre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Diagnostic
|
- Interleukin 8 (IL-8)
- Receptor for advanced glycation end products (RAGE)
- Systolic blood pressure
- (and 9 more...)
|
40 |
All |
Child, Adult, Senior |
NCT03464071 |
170580 |
|
March 12, 2018 |
July 1, 2019 |
December 20, 2019 |
March 13, 2018 |
March 13, 2018 |
|
|
| 4 |
NCT03169452 |
Recruiting |
Clinical Application and Outcome of Non-invasive Ventilation in Different Chest Diseases |
|
- Device: Non-invasive mechanical ventilator
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- percentage of patients need mechanical ventilation
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT03169452 |
NIV |
|
June 1, 2017 |
January 2018 |
April 2018 |
May 30, 2017 |
July 11, 2017 |
|
- Assiut University
Assiut, Egypt
|
| 5 |
NCT02751047 |
Recruiting |
Manual Ventilation Versus Pressure Controlled Mechanical Ventilation in Children |
|
- Other: manual ventilation
- Other: Pressure controlled mechanical ventilation
|
Interventional |
Not Applicable |
- Seoul National University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of gastric insufflation
- The number of patients with adequate tidal volume
|
154 |
All |
1 Month to 5 Years (Child) |
NCT02751047 |
H1602-094-741 |
|
May 2016 |
October 2017 |
|
April 26, 2016 |
June 20, 2016 |
|
- Seoul National University Hospital
Seoul, Korea, Republic of
|
| 6 |
NCT02247700 |
Recruiting |
Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography |
- Respiratory Failure
- Acute Respiratory Distress Syndrome
- Acute Lung Injury
|
|
Observational |
|
- Boston Children’s Hospital
- Draeger Medical, Inc
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Distribution of Ventilation
- Distribution of Ventilation Changes Over Time
|
50 |
All |
up to 17 Years (Child) |
NCT02247700 |
IRB-P00013295 |
EIT |
October 1, 2014 |
November 1, 2018 |
March 1, 2019 |
September 25, 2014 |
October 27, 2017 |
|
- Boston Children's Hospital
Boston, Massachusetts, United States
|
| 7 |
NCT02961920 |
Recruiting |
The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients |
|
- Device: IE ratio 1:1
- Device: IE ratio 1:2
|
Observational |
|
- Gachon University Gil Medical Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
50 |
All |
20 Years to 65 Years (Adult) |
NCT02961920 |
PrIspSp |
|
November 2016 |
September 2018 |
October 2018 |
November 11, 2016 |
December 6, 2017 |
|
- Kyung Cheon Lee
Incheon, Korea, Republic of
|
| 8 |
NCT03473171 |
Recruiting
New |
Implementation of Nasal Non-Invasive Ventilation With a RAM Cannula in the Inpatient /Outpatient Setting |
- Chronic Respiratory Failure
|
- Device: Nasal non-invasive ventilation with RAM cannula
|
Interventional |
Not Applicable |
- The University of Texas Health Science Center, Houston
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Feasibility as assessed by number of participants who had complications
|
50 |
All |
up to 21 Years (Child, Adult) |
NCT03473171 |
HSC-MS-17-0708 |
|
March 31, 2018 |
March 31, 2019 |
March 31, 2019 |
March 22, 2018 |
March 23, 2018 |
|
- The University of Texas Health Science Center at Houston
Houston, Texas, United States
|
| 9 |
NCT03243539 |
Recruiting |
Implementation of Neuro Lung Protective Ventilation |
- Acute Brain Injury
- Traumatic Brain Injury
- Intracerebral Hemorrhage
- (and 3 more...)
|
- Procedure: Lung Protective Ventilation
|
Interventional |
Not Applicable |
- Colin Grissom
- Intermountain Health Care, Inc.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient-Level Proportion of time on Mechanical Ventilation with a Tidal Volume <= 6.5 ml/kg PBW
- Proportion of time with a target PaCO2 of 35 to 45 mm Hg
- Average number of protocol deviations for all subjects (protocol compliance)
- (and 8 more...)
|
728 |
All |
18 Years and older (Adult, Senior) |
NCT03243539 |
1050582 |
NEUROVENT |
August 31, 2017 |
August 15, 2018 |
December 31, 2018 |
August 9, 2017 |
August 30, 2017 |
|
- Intermountain Medical Center
Murray, Utah, United States
|
| 10 |
NCT03141216 |
Recruiting |
Effects of Mechanical Ventilation on Pulmonary Electrical Impedance, Diaphragmatic Mobility and Patient-ventilator Synchrony |
|
- Device: VCV+PSV
- Device: PCV+PSV
|
Interventional |
Not Applicable |
- Universidade Federal de Pernambuco
- Real Hospital Português de Beneficência em Pernambuco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- electrical impedance measures
- gas blood analysis data
- diaphragmatic mobility
- patient-ventilator synchrony
|
50 |
All |
18 Years to 65 Years (Adult) |
NCT03141216 |
03021991 |
|
March 9, 2017 |
December 31, 2017 |
June 2018 |
May 5, 2017 |
March 20, 2018 |
|
- Hospital Real Português de Beneficência em Pernambuco
Recife, Pernambuco, Brazil
|
| 11 |
NCT03288558 |
Recruiting |
Protective Mechanical VENTilation Strategy in Patients Undergoing CARDiac Surgery |
- Pulmonary Complications
- Cardiac Surgery
|
- Other: A comprehensive perioperative mechanical ventilation strategy
|
Interventional |
Not Applicable |
- University Health Network, Toronto
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Post-operative pulmonary complications
- Ventilator free days
- Intensive care length of stay
- (and 8 more...)
|
310 |
All |
18 Years and older (Adult, Senior) |
NCT03288558 |
17-5171 |
|
July 7, 2017 |
October 30, 2019 |
June 1, 2020 |
September 20, 2017 |
September 21, 2017 |
|
- Toronto General Hospital, University Health Network
Toronto, Ontario, Canada
|
| 12 |
NCT03231735 |
Recruiting |
Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome |
- Ventilator-Induced Lung Injury
- Respiratory Distress Syndrome
- Bronchopulmonary Dysplasia
- Preterm Infant
|
- Device: Mid frequency ventilation
- Device: Standard frequency ventilation
|
Interventional |
Phase 2
Phase 3 |
- University of Alabama at Birmingham
- University of South Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Alive ventilator free days
- Alive at day 28 after birth
- Ventilator free
- (and 13 more...)
|
130 |
All |
up to 3 Days (Child) |
NCT03231735 |
F160701002 |
MIDAS |
August 2, 2017 |
July 31, 2019 |
July 31, 2019 |
July 27, 2017 |
August 3, 2017 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - University of South Alabama
Mobile, Alabama, United States
|
| 13 |
NCT02932189 |
Recruiting |
Use of a New Isokinetic Device for Inspiratory Muscle Training |
|
- Device: Inspiratory muscle training
|
Interventional |
Not Applicable |
- Universidade Federal Fluminense
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Supportive Care
|
- Successful weaning
- Change in maximal inspiratory strength in cm H2O as measured by the digital manovacuometer MVD300 for 60 seconds
- Change in the timed inspiratory effort index in cm H2O/sec as calculated by the ratio of the maximal inspiratory pressure and time demanded to reach it as measured by the digital manovacuometer MVD300 for 60 seconds
- Time off the ventilator in the ICU in days.
|
70 |
All |
18 Years to 86 Years (Adult, Senior) |
NCT02932189 |
isokinetic device |
|
January 2016 |
January 2018 |
January 2018 |
October 13, 2016 |
May 30, 2017 |
|
- Hospital Naval Marcilio Dias
Rio de Janeiro, RJ, Brazil
|
| 14 |
NCT03226925 |
Recruiting |
Mechanically-assisted Ventilation in the Treatment of Moving Tumours With Photon and Proton Therapies |
- Thoracic Neoplasm
- Liver Cancer
- Ventilator Lung
- Radiotherapy; Complications
|
- Diagnostic Test: Non-invasive mechanically-assisted ventilation
- Diagnostic Test: Dynamic MRI acquisition
- Diagnostic Test: Planning 4D-CT
|
Interventional |
Not Applicable |
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Measure in millimeters of the internal motion during non-invasive mechanically assisted ventilation, based on MRI images
- Tolerance assessment
- Internal motion reproducibility with non-invasive mechanically assisted ventilation.
- Dosimetric comparison
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03226925 |
2017/23MAI/294 |
|
June 30, 2017 |
April 30, 2018 |
April 30, 2018 |
July 24, 2017 |
July 24, 2017 |
|
- Cliniques Universitaires Saint-Luc
Brussels, Belgium
|
| 15 |
NCT03230617 |
Not yet recruiting |
Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients |
- Pulmonary Disease, Chronic Obstructive
|
- Device: Mechanical ventilator
|
Observational |
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- The duration of mechanical ventilation
|
100 |
All |
Child, Adult, Senior |
NCT03230617 |
EDHMVCP |
|
September 1, 2017 |
September 1, 2018 |
December 31, 2018 |
July 26, 2017 |
July 27, 2017 |
|
- Assiut University
Assiut, Egypt
|
| 16 |
NCT03479047 |
Recruiting
New |
Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI) |
- Mechanical Ventilation
- Mechanical Ventilator Weaning
- Extubation
- Diaphragm Ultrasound
|
- Diagnostic Test: assess diaphragmatic displacement (DD) using ultrasonography
|
Interventional |
Not Applicable |
- Centre Hospitalier Régional d'Orléans
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Difference between the RSBI area and the RSDI AUC
- Find a cut-off value for RSDI
- Compare traditional RSBI values recorded with scientific publications
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT03479047 |
CHRO-2018-02 |
CODEX |
March 23, 2018 |
March 22, 2019 |
March 22, 2019 |
March 27, 2018 |
April 9, 2018 |
|
- CHR d'Orléans
Orléans, France
|
| 17 |
NCT02883465 |
Recruiting |
Ultrasound Diagnostic for Diaphragmatic Dysfunction in Reanimation |
- Mechanical Ventilation Weaning
|
- Procedure: Diaphragmatic ultrasound
|
Interventional |
Not Applicable |
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
- Poitiers University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Extubation success rate
- Length of stay in reanimation unit (days)
- Length of mechanical ventilation
- (and 11 more...)
|
180 |
All |
18 Years and older (Adult, Senior) |
NCT02883465 |
SJSL12014 |
ECHODIAPH II |
March 2015 |
September 2016 |
December 2016 |
August 30, 2016 |
August 30, 2016 |
|
- Centre Hospitalier Saint Joseph Saint Luc
Lyon, France - Centre Hospitalier Annecy Genevois
Metz-Tessy, France - Centre Hospitalier Universitaire de Poitiers
Poitiers, France
|
| 18 |
NCT03303040 |
Recruiting |
Effect of Diaphragm Stimulation During Surgery |
- Mechanical Ventilation Complication
- Diaphragm Injury
|
- Other: Electrical stimulation of hemidiaphragm
|
Interventional |
Not Applicable |
- University of Florida
- National Institutes of Health (NIH)
- University of Arizona
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Mitochondrial respiration
- Mitochondrial reactive oxygen species production
- Mitochondrial DNA mutation frequency
- (and 25 more...)
|
54 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT03303040 |
IRB201602186-N
1R01AR072328-01 |
|
February 14, 2018 |
June 2021 |
June 2021 |
October 5, 2017 |
April 5, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
| 19 |
NCT02630784 |
Recruiting |
Efficacy and Safety of Non-invasive Ventilation by Calibrated Leak in the Treatment of Respiratory Acidosis in ICU |
- Respiratory Acidosis in ICU Patients
|
- Procedure: Non-Invasive Ventilation with Homecare ventilator
- Procedure: Non-Invasive Ventilation with ICU ventilator
|
Interventional |
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Carbon dioxide arterial pressure (PaCO2)
- Arterial blood acidity (pH) after 2 hours of NIV
- Transcutaneous PCO2
- (and 4 more...)
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02630784 |
2014-A00844-43 |
VNI Versus |
April 2015 |
October 2017 |
October 2017 |
December 15, 2015 |
November 17, 2016 |
|
- CHU de Michallon
Grenoble, France
|
| 20 |
NCT03180203 |
Recruiting |
Postoperative INTELLiVENT-ASV Ventilation. |
- Ventilators, Mechanical
- Intensive Care Units
- Postoperative Care
|
- Device: INTELLiVENT-ASV
- Device: Conventional modes
|
Interventional |
Not Applicable |
- Catharina Ziekenhuis Eindhoven
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage (%) of mechanical ventilation time in an optimal, acceptable or unacceptable ventilation zone.
- The percentage (%) of successful extubations.
- Postoperative weaning time
- (and 9 more...)
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT03180203 |
NL58975.100.16 |
POSITiVE |
May 22, 2017 |
December 31, 2017 |
June 30, 2018 |
June 8, 2017 |
June 8, 2017 |
|
- Catharina Hospital
Eindhoven, Noord-Brabant, Netherlands
|
| 21 |
NCT02680704 |
Recruiting |
Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure |
- Intracranial Hypertension
- Critical Illness
- Brain Injuries
- (and 3 more...)
|
- Other: PEEP titrated mechanical ventilation
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Association between PEEP and ICP
- Association between transpulmonary pressure and ICP
- Association between PEEP and cerebral hemodynamics
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02680704 |
2015P000089 |
|
February 2016 |
January 2019 |
January 2019 |
February 11, 2016 |
March 7, 2018 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
| 22 |
NCT03372252 |
Recruiting |
Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation |
- Respiration Disorder
- Respiratory Failure
- Weaning Failure
- (and 2 more...)
|
- Device: Electroencephalography
|
Interventional |
Not Applicable |
- Poitiers University Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Magnitude of inspiratory premotor potentials
|
70 |
All |
18 Years and older (Adult, Senior) |
NCT03372252 |
BRAIN-WEAN |
|
February 21, 2017 |
May 1, 2018 |
November 1, 2018 |
December 13, 2017 |
December 13, 2017 |
|
- university hospital center of Poitiers
Poitiers, Vienne, France
|
| 23 |
NCT02871102 |
Recruiting |
Stress Index to Individualize Mechanical Ventilation in ARDS |
- Acute Respiratory Distress Syndrome
|
- Procedure: Recruitment Maneuver with PEEP and Tidal Volume Optimization
|
Interventional |
Not Applicable |
- Vanderbilt University
- Vanderbilt University Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Comparison of ARDSnet-optimized and protocol-optimized tidal volume
- Comparison of ARDSnet-optimized and protocol-optimized driving pressure
- Comparison of ARDSnet-optimized and protocol-optimized PEEP
- Comparison of ARDSnet-optimized and protocol-optimized elastance
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT02871102 |
160770 |
|
August 2016 |
June 2018 |
|
August 18, 2016 |
September 21, 2017 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
| 24 |
NCT03250793 |
Not yet recruiting |
Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation. |
- Hernia, DIaphragmatic, Congenital
|
- Device: Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Work of breathing averaged over 100 consecutive cycles in NAVA ventilation and conventional ventilation
- Patient-ventilator synchronization in NAVA
- Patient-ventilator synchronization in conventional ventilation
- (and 28 more...)
|
12 |
All |
1 Year and older (Child, Adult, Senior) |
NCT03250793 |
69HCL17_0429 |
NAVA-DIAPH |
November 1, 2017 |
November 1, 2018 |
November 1, 2018 |
August 16, 2017 |
August 16, 2017 |
|
- Service de Réanimation Néonatale- Hôpital Femme Mère Enfant- Hospices Civils de Lyon
Bron, France
|
| 25 |
NCT02998294 |
Recruiting |
Respiratory Volume Measure Using ExSpiron 1Xi |
- ICU(Intensive Care Unit) Patients
- Mechanical Ventilation After Surgery
|
- Device: Respiratory Volume Monitor(RVM)
- Device: artificial respirator
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Respiratory volume measure using ExSpiron 1Xi
|
65 |
All |
19 Years and older (Adult, Senior) |
NCT02998294 |
1-2016-0008 |
|
March 2016 |
December 2017 |
December 2017 |
December 20, 2016 |
December 20, 2016 |
|
- Department of Anesthesiology and Pain Medicine, Anesthesia and Pain Research Institute, Yonsei University College of Medicine
Seoul, Korea, Republic of
|
| 26 |
NCT03498807 |
Recruiting
New |
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients |
- ARDS
- Acute Respiratory Distress Syndrome
|
- Device: Ventiltor P/V Loop
- Device: Electrical Impedance Tomography
|
Interventional |
Not Applicable |
- Hui-Ju Hsu
- Far Eastern Memorial Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Mortality rate in the hospital
|
80 |
All |
20 Years to 99 Years (Adult, Senior) |
NCT03498807 |
106094-E |
|
August 28, 2017 |
July 31, 2018 |
July 31, 2018 |
April 17, 2018 |
April 17, 2018 |
|
- Far Eastern Memorial Hospital
Taipei county, Banqiao Dist, Taiwan
|
| 27 |
NCT02915458 |
Recruiting |
Predictive Analysis Software for Successful Weaning From Ventilator of Patients |
|
|
Observational |
|
- Chang Gung Memorial Hospital
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Successful weaning from mechanical ventilation
|
188 |
All |
18 Years and older (Adult, Senior) |
NCT02915458 |
104-6531B |
|
January 2016 |
December 2017 |
December 2017 |
September 27, 2016 |
September 27, 2016 |
|
- Department of Thoracic Medicine, Chang Gung Memorial Hospital
Taoyuan, Taiwan
|
| 28 |
NCT03300648 |
Not yet recruiting |
Treating Brain Swelling in Pediatric Cerebral Malaria |
|
- Other: Mechanical ventilation
- Other: Hypertonic saline
|
Interventional |
Phase 3 |
- Michigan State University
- Washington University School of Medicine
- University of Maryland
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mortality
- Neurodevelopmental disability
|
261 |
All |
6 Months to 12 Years (Child) |
NCT03300648 |
TBS
U01AI126610 |
TBS |
January 8, 2018 |
November 30, 2023 |
November 30, 2023 |
October 3, 2017 |
October 3, 2017 |
|
- Queen Elizabeth Central Hospital
Blantyre, Malawi
|
| 29 |
NCT02779998 |
Recruiting |
Prophylactic Non-invasive Ventilation During Surgical Procedure in Rhythmology |
- Cardiac Electrophysiology
- Anesthesia
- Acute Respiratory Failure
|
- Other: non invasive ventilation
- Other: Standard oxygen therapy with facial mask
|
Interventional |
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Respiratory event
- Occurence of hemodynamic instability
- Respiratory rate
- (and 11 more...)
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT02779998 |
38RC15.163 |
VNI-RYTHMO |
January 2017 |
May 2018 |
May 2018 |
May 23, 2016 |
January 12, 2017 |
|
- Grenoble University Hospital
La Tronche, France
|
| 30 |
NCT02896673 |
Recruiting |
Evaluation of the Diagnostic Performance of Electrical Impedance Tomography to Detect Situations at Risk of Lesions Induced by Conventional Mechanical Ventilation in ARDS |
- Respiratory Distress Syndrome
|
- Procedure: ventilatory conditions and measures with scanner and EIT
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- mean values of optimal PEP obtained by EIT
- mean values of optimal TV obtained by EIT
- mean values of optimal PEP obtained by scan
- mean values of optimal TV obtained by scan
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT02896673 |
2010-642 |
|
June 2011 |
July 2018 |
July 2018 |
September 12, 2016 |
September 12, 2016 |
|
- Hôpital de la Croix Rousse
Lyon, France
|
| 31 |
NCT03491332 |
Not yet recruiting
New |
Effect of Heated Breathing Circuit on Intraoperative Core Temperature and Systemic Inflammation After Brain Surgery: a Prospective Randomized Study |
- Patients Scheduled for Brain Surgery
|
- Device: conventional circuit
- Device: conventional humidification circuit
- Device: new humidifaction heat circuit
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- core temperature
- upper airway temperature
- upper airway humidity
- (and 5 more...)
|
117 |
All |
19 Years and older (Adult, Senior) |
NCT03491332 |
1-2017-0087 |
|
April 2018 |
February 2019 |
February 2019 |
April 9, 2018 |
April 9, 2018 |
|
|
| 32 |
NCT02545803 |
Recruiting |
The Effect of High Frequency Percussive Ventilation on Cerebral Tissue Oxygenation |
- Patients at the Intensive Care Unit (ICU)
|
- Device: Near-Infrared Spectroscopy (NIRS)
|
Interventional |
Not Applicable |
- Hasselt University
- Ziekenhuis Oost-Limburg
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- The association between HFPV and cerebral oxygen saturation
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT02545803 |
VDR4_ZOL1 |
|
May 2015 |
May 2018 |
May 2018 |
September 10, 2015 |
March 27, 2018 |
|
- Ziekenhuis Oost-Limburg
Genk, Belgium
|
| 33 |
NCT03120793 |
Recruiting |
ARDS Esophageal Balloon Pressure Changes With Positioning Study |
|
- Device: Esophageal balloon catheter
|
Observational |
|
- University of North Carolina, Chapel Hill
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Esophageal pressure measurements from upright to prone position
- Change in Esophageal pressure measurements from upright to supine position
- Change in Transmural pressure measurements from upright to prone position
- (and 3 more...)
|
10 |
All |
18 Years and older (Adult, Senior) |
NCT03120793 |
17-0135 |
|
May 11, 2017 |
September 20, 2018 |
September 20, 2018 |
April 19, 2017 |
October 26, 2017 |
|
- University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States
|
| 34 |
NCT03079102 |
Recruiting |
Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest |
- Heart Arrest, Out-Of-Hospital
|
- Drug: Nitric Oxide
- Drug: Nitrogen
|
Interventional |
Phase 2 |
- Cameron Dezfulian
- Mallinckrodt
- University of Pittsburgh
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Death or significant neurological or cardiac impairment
- Death
- Cerebral performance category (CPC)
- (and 11 more...)
|
130 |
All |
18 Years and older (Adult, Senior) |
NCT03079102 |
PRO16100408 |
iNOOHCA |
August 21, 2017 |
August 20, 2020 |
November 17, 2020 |
March 14, 2017 |
March 29, 2018 |
|
- UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States - UPMC Mercy Hospital
Pittsburgh, Pennsylvania, United States
|
| 35 |
NCT03279458 |
Recruiting |
Non-invasive Tidal Volume Monitoring Using the Linshom Respiratory Monitoring Device |
- Pulmonary Ventilation
- Capnography
|
- Device: Linshom Respiratory Monitoring Device
|
Interventional |
Not Applicable |
- University of Mississippi Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Tidal volume of each breath
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03279458 |
2017-0063 |
|
September 2017 |
September 2017 |
December 2017 |
September 12, 2017 |
September 12, 2017 |
|
- University of Mississippi Medical Center
Jackson, Mississippi, United States
|
| 36 |
NCT02782871 |
Not yet recruiting |
A RCT to Compare the Pneupac VR1 Portable Ventilator and Manual Ventilation Via a Mapleson C- Circuit During the Intra-hospital Transfers of Intubated Patients |
|
|
Interventional |
Not Applicable |
- Brighton and Sussex University Hospitals NHS Trust
- St Thomas' Hospital, London
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
|
- Pre- and post transfer partial pressure carbon dioxide measurements, from blood samples, taken from in-situ arterial line
|
63 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02782871 |
GSTT 2016 |
|
June 2016 |
June 2017 |
June 2017 |
May 25, 2016 |
May 25, 2016 |
|
|
| 37 |
NCT02566512 |
Recruiting |
Assessment of Cough Strength in Patients With Tracheostomies |
- Mechanical Ventilator Weaning
|
- Other: Tracheostomy cuff inflation.
- Other: Tracheostomy cuff deflation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Peak expiratory flow rate
|
20 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02566512 |
B2015:068 |
|
September 2015 |
December 2017 |
December 2017 |
October 2, 2015 |
October 27, 2017 |
|
- Health Sciences Centre
Winnipeg, Manitoba, Canada
|
| 38 |
NCT02354365 |
Recruiting |
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation |
- Transpulmonary Pressure
- Pressure.Rate Product
- Guide to Mechanical Ventilator Management
- Extubation Readiness
|
- Device: Transpulmonary Pressure measurement
|
Observational |
|
- Children's Hospital Los Angeles
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Transpulmonary pressure and Pressure rate product
|
60 |
All |
up to 18 Years (Child, Adult) |
NCT02354365 |
13-00370 |
|
February 2014 |
December 2020 |
December 2021 |
February 3, 2015 |
January 25, 2018 |
|
- Children's Hospital Los Angeles
Los Angeles, California, United States
|
| 39 |
NCT02894879 |
Recruiting |
Effectiveness Of Modified Chest PT Technidue In Pre And Post-Operative Program In Patients Open Heart Surgery |
|
- Device: BreatheMAX®
- Other: Routine treatment
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Incidence of PPCs,
- The duration of breathing with a mode of mechanical ventilator and duration of intubation time
- length of ICU and hospital stay
- Pulmonary function test
|
48 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT02894879 |
Effect of modify chest PT |
|
September 2016 |
April 2017 |
April 2017 |
September 9, 2016 |
October 14, 2016 |
|
- Khon Kaen hospital
Maung Khon Kaen, KhonKaen, Thailand
|
| 40 |
NCT02284178 |
Recruiting |
Oral Suction Intervention to Reduce Aspiration and Ventilator Events: NO-ASPIRATE |
|
- Other: Enhanced oropharyngeal suction
- Other: Usual Care
|
Interventional |
Not Applicable |
- University of Central Florida
- Orlando Regional Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Microaspiration as measured by tracheal amylase
|
520 |
All |
18 Years and older (Adult, Senior) |
NCT02284178 |
1R01NR014508-01A1 |
NO-ASPIRATE |
August 2014 |
August 2017 |
January 31, 2018 |
November 5, 2014 |
October 26, 2017 |
|
- Orlando Regional Medical Center
Orlando, Florida, United States
|
| 41 |
NCT02598492 |
Recruiting |
Imputation of PaO2 From SaO2 |
- Acute Respiratory Failure
|
- Other: arterial blood gas
|
Observational |
|
- Brigham and Women's Hospital
- Chinese PLA General Hospital
- Tianjin Nankai Hospital
- (and 13 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To evaluate the relationship between PaO2 and SaO2 among mechanically ventilated patients
- To utilize SF ratios to impute the PF ratios in assessing the respiratory parameter of the SOFA score
|
1000 |
All |
18 Years and older (Adult, Senior) |
NCT02598492 |
2015P001945 |
|
September 2015 |
September 2017 |
September 2017 |
November 6, 2015 |
July 17, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - Gansu Provinical Hospital
Lanzhou, Gansu, China - Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China - (and 22 more...)
|
| 42 |
NCT03415529 |
Not yet recruiting |
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS |
- Acute Severe Respiratory Failure
- Acute Respiratory Distress Syndrome
|
|
Observational |
|
- European Society of Intensive Care Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Incidence
- Severity
- Hypercapnia
- pH ((potential of hydrogen)
|
4500 |
All |
18 Years and older (Adult, Senior) |
NCT03415529 |
CO2LUNGSAFE |
CO2 LUNG SAFE |
March 1, 2018 |
September 30, 2018 |
December 30, 2018 |
January 30, 2018 |
January 31, 2018 |
|
|
| 43 |
NCT02687802 |
Recruiting |
Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation |
- Respiratory Insufficiency
|
- Other: mechanical ventilation
|
Observational |
|
- University of Sao Paulo General Hospital
- Fundação de Amparo à Pesquisa do Estado de São Paulo
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- asynchrony index
- Clinical signs of patient-ventilator asynchrony
- ventilation free-days
- (and 2 more...)
|
110 |
All |
18 Years and older (Adult, Senior) |
NCT02687802 |
2015/19122-4 |
EpiSync |
August 2016 |
December 2017 |
July 2018 |
February 22, 2016 |
April 4, 2017 |
|
- Hospital das Clínicas -HCFMUSP
Sao Paulo, SP, Brazil
|
| 44 |
NCT02025127 |
Recruiting |
A Randomized Controlled Study of Enteral Nutrition in Septic Shock |
|
|
Interventional |
Not Applicable |
- Medical College of Wisconsin
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Intensive care unit free days
- Ventilator free days
- Mortality
- (and 2 more...)
|
64 |
All |
18 Years and older (Adult, Senior) |
NCT02025127 |
19966 |
|
January 2014 |
April 2018 |
April 2018 |
December 31, 2013 |
August 18, 2017 |
|
- Froedtert Hospital
Milwaukee, Wisconsin, United States
|
| 45 |
NCT02819141 |
Recruiting |
Self-management of Sedative Therapy by Ventilated Patients |
- Critical Illness
- Anxiety
- Respiratory Failure
|
|
Interventional |
Phase 2
Phase 3 |
- Mayo Clinic
- University of Minnesota, MN
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in duration of days receiving mechanical ventilation after study enrollment
- Changes in delirium using the CAM-ICU tool
- Changes in anxiety using the 100mm vertical visual analog scale
- (and 2 more...)
|
228 |
All |
18 Years and older (Adult, Senior) |
NCT02819141 |
16-000417
R01HL030881 |
|
November 2016 |
April 2021 |
November 2021 |
June 30, 2016 |
April 13, 2017 |
|
- School of Medicine, University of Minnesota
Minneapolis, Minnesota, United States - Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 46 |
NCT03326414 |
Not yet recruiting |
Influence of Different PEEP Levels and Tidal Volumes on Regional Lung Function |
- Pulmonary Ventilation; Newborn, Abnormal
|
- Procedure: Constant PEEP - low tidal volume
- Procedure: Constant PEEP - high tidal volume
- Procedure: constant tidal volume - low PEEP
- Procedure: constant tidal volume - high PEEP
|
Interventional |
Not Applicable |
- Universitätsklinikum Hamburg-Eppendorf
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change of "dependent silent spaces" (DSS) and "non-dependent silent spaces" (NSS)
- Oxygenation index
- complinace of the respiratory system
|
40 |
Male |
18 Years and older (Adult, Senior) |
NCT03326414 |
ANA-UKE-PV5538 |
|
January 2018 |
April 2018 |
June 2018 |
October 31, 2017 |
October 31, 2017 |
|
- Department of Anaesthesiology Center of Anaesthesiology and Intensive Care Medicine University Medical Center Hamburg-Eppendorf University of Hamburg
Hamburg, Germany
|
| 47 |
NCT02836899 |
Recruiting |
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. |
|
- Drug: Nitric Oxide
- Other: Placebo
|
Interventional |
Phase 3 |
- Massachusetts General Hospital
- Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital
- Kenneth, Shelton, M.D., Massachusetts General Hospital
- (and 11 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Acute kidney injury
- AKI severity
- Renal replacement therapy
- (and 7 more...)
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT02836899 |
MGH K23
K23HL128882-01 |
MGHK23 |
February 8, 2017 |
December 31, 2020 |
December 31, 2021 |
July 19, 2016 |
March 22, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
| 48 |
NCT02796430 |
Recruiting |
The ICALIC International Multicentric Study |
|
- Other: Time needed to start indirect calorimetry measurement
- Other: Indirect calorimetry measurement
|
Observational |
|
- University Hospital, Geneva
- European Society of Intensive Care Medicine
- The European Society for Clinical Nutrition and Metabolism
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Time needed to start indirect calorimetry (IC) measurement in Q-NRG compared to currently used calorimeters
- Comparison of energy expenditure(EE) from Q-NRG and currently used calorimeters
- Coefficient of variation (CV) of EE for different mechanical ventilators
- (and 4 more...)
|
343 |
All |
18 Years and older (Adult, Senior) |
NCT02796430 |
15-137 |
ICALIC |
September 10, 2017 |
March 31, 2018 |
September 30, 2018 |
June 10, 2016 |
September 12, 2017 |
|
- Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine
Vienna, Austria - Department of Intensive Care, Vrije Universiteit Brussel
Brussels, Belgium - Critical Care Medicine, Institute for Nutrition Research, Rabin Medical Center, Beilison Hospital
Petah Tikva, Israel - (and 4 more...)
|
| 49 |
NCT02643381 |
Recruiting |
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial |
- Cardiopulmonary Arrest
- Respiratory Arrest
|
- Drug: Etomidate
- Drug: Ketamine
- Procedure: Emergency Endotracheal Intubation
- Device: Mechanical Ventilation
|
Interventional |
Phase 4 |
- University of Texas Southwestern Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Survival
- Sequential Organ Failure Assessment (SOFA) scores
- Immediate outcomes of endotracheal intubation.
- (and 4 more...)
|
825 |
All |
18 Years and older (Adult, Senior) |
NCT02643381 |
022015-023 |
EvK |
June 2016 |
April 2019 |
April 2021 |
December 31, 2015 |
October 30, 2017 |
|
- Parkland Hospital
Dallas, Texas, United States
|
| 50 |
NCT03436225 |
Not yet recruiting |
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy. |
- Bronchiolitis; Respiratory Syncytial Virus
|
- Drug: Dexamethasone orally.
- Drug: Dexamethasone parenteral.
- Drug: Inhaled nebulized Budesonide.
- Drug: Inhaled nebulized salbutamol.
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Resolution of respiratory distress.
- Reduction of mean duration of symptoms.
- Reduction of duration of oxygen therapy.
- Reduction of average Length of hospital stay.
|
80 |
All |
3 Months to 2 Years (Child) |
NCT03436225 |
Steroid in bronchiolitis. |
|
February 2018 |
February 2019 |
March 2019 |
February 16, 2018 |
February 20, 2018 |
|
|
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