| 1 |
NCT03522493 |
Recruiting |
The Effect of Age and Inspiratory Resistance on the Inspiratory Gas Levels While Wearing Air Purifying Respirator " |
|
|
Interventional
|
Not Applicable |
- Medical Corps, Israel Defense Force
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Average CO2 (%)
- Respiratory discomfort (borg scale 1-10)
- Average O2 (%)
|
40 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03522493 |
1552-2015 |
|
July 2016 |
August 2018 |
August 2018 |
May 11, 2018 |
May 11, 2018 |
|
- Israel Naval Medical Institute
Haifa, Israel
|
|
| 2 |
NCT03169452 |
Recruiting |
Clinical Application and Outcome of Non-invasive Ventilation in Different Chest Diseases |
|
- Device: Non-invasive mechanical ventilator
|
Observational
|
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- percentage of patients need mechanical ventilation
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT03169452 |
NIV |
|
June 1, 2017 |
August 2018 |
November 2018 |
May 30, 2017 |
July 3, 2018 |
|
- Assiut University
Assiut, Egypt
|
|
| 3 |
NCT03042598 |
Recruiting |
Biphasic Ventilation Airway Management Clinical Trial |
|
- Device: Biphasic Cuirass Ventilation
|
Interventional
|
Not Applicable |
- University Medical Center of Southern Nevada
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Composite Primary Endpoint is the composite prevalence of any desaturation defined as SPO2 < 95% or Bradycardia, HR <60 beats per minute sustained for at least 30 seconds
- Prevalence of post-paralytic Bag valve mask use
- Waveform capnography pattern
- (and 3 more...)
|
15 |
All |
18 Years and older (Adult, Older Adult) |
NCT03042598 |
EM 2016.05 |
BVAM |
January 14, 2017 |
April 2017 |
April 2017 |
February 3, 2017 |
February 3, 2017 |
|
- University Medical Center of Southern Nevada
Las Vegas, Nevada, United States
|
|
| 4 |
NCT03114384 |
Recruiting |
Patient-ventilator Asynchrony During Noninvasive Ventilation Assessed Using Diaphragm Ultrasonography |
|
- Other: Creation and detection of patient-respirator asynchronies
|
Interventional
|
Not Applicable |
- Centre Hospitalier Saint Joseph Saint Luc de Lyon
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Asynchronies detection with diaphragm ultrasonography
|
15 |
All |
18 Years and older (Adult, Older Adult) |
NCT03114384 |
2017-A00346-47 |
ADULT |
April 14, 2017 |
July 30, 2017 |
July 30, 2017 |
April 14, 2017 |
April 14, 2017 |
|
- Groupe Hospitalier Henri Mondor
Creteil, France
|
|
| 5 |
NCT03464071 |
Recruiting |
Biomarkers of Lung Injury in Hyperinflation in the Mechanical Ventilator Versus Manual Hyperinflation |
|
- Device: Hyperinflation with mechanical ventilator
- Device: Manual hyperinflation
|
Interventional
|
Not Applicable |
- Hospital de Clinicas de Porto Alegre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Diagnostic
|
- Interleukin 8 (IL-8)
- Receptor for advanced glycation end products (RAGE)
- Systolic blood pressure
- (and 9 more...)
|
40 |
All |
Child, Adult, Older Adult |
NCT03464071 |
170580 |
|
March 23, 2018 |
July 1, 2019 |
December 20, 2019 |
March 13, 2018 |
July 3, 2018 |
|
- Hospital de Clínicas de Porto Alegre
Porto Alegre, Rio Grande Do Sul, Brazil
|
|
| 6 |
NCT02247700 |
Recruiting |
Observational Cohort Study of Distribution of Ventilation in Pediatrics Requiring Mechanical Ventilation by Electrical Impedance Tomography |
- Respiratory Failure
- Acute Respiratory Distress Syndrome
- Acute Lung Injury
|
|
Observational
|
|
- Boston Children’s Hospital
- Draeger Medical, Inc
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Distribution of Ventilation
- Distribution of Ventilation Changes Over Time
|
50 |
All |
up to 17 Years (Child) |
NCT02247700 |
IRB-P00013295 |
EIT |
October 1, 2014 |
November 1, 2018 |
March 1, 2019 |
September 25, 2014 |
October 27, 2017 |
|
- Boston Children's Hospital
Boston, Massachusetts, United States
|
|
| 7 |
NCT03512067 |
Not yet recruiting |
Entrainment-Based Mechanical Ventilation |
- Respiratory Insufficiency
- Respiratory Failure
- Mechanical Ventilation Complication
|
- Device: Patients given EMV Ventilation
|
Interventional
|
Not Applicable |
- Brigham and Women's Hospital
- Massachusetts Institute of Technology
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Feasibility Evaluation
- Assess for Frequency of Complications Related to the Use of EMV
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT03512067 |
2013P001506
5R34HL125859-02 |
|
August 1, 2018 |
February 1, 2020 |
April 1, 2020 |
April 30, 2018 |
July 10, 2018 |
|
|
|
| 8 |
NCT02961920 |
Recruiting |
The Effect of Prolonged Inspiratory Time on Pulmonary Mechanics in Obese Patients |
|
- Device: IE ratio 1:1
- Device: IE ratio 1:2
|
Observational
|
|
- Gachon University Gil Medical Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
50 |
All |
20 Years to 65 Years (Adult, Older Adult) |
NCT02961920 |
PrIspSp |
|
July 2016 |
March 2019 |
May 2019 |
November 11, 2016 |
August 7, 2018 |
|
- Kyung Cheon Lee
Incheon, Korea, Republic of
|
|
| 9 |
NCT03473171 |
Recruiting |
Implementation of Nasal Non-Invasive Ventilation With a RAM Cannula in the Inpatient /Outpatient Setting |
- Chronic Respiratory Failure
|
- Device: Nasal non-invasive ventilation with RAM cannula
|
Interventional
|
Not Applicable |
- The University of Texas Health Science Center, Houston
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Feasibility as assessed by number of participants who had complications
|
50 |
All |
up to 21 Years (Child, Adult) |
NCT03473171 |
HSC-MS-17-0708 |
|
April 1, 2018 |
March 31, 2019 |
March 31, 2019 |
March 22, 2018 |
May 2, 2018 |
|
- The University of Texas Health Science Center at Houston
Houston, Texas, United States
|
|
| 10 |
NCT03243539 |
Recruiting |
Implementation of Neuro Lung Protective Ventilation |
- Acute Brain Injury
- Traumatic Brain Injury
- Intracerebral Hemorrhage
- (and 3 more...)
|
- Procedure: Lung Protective Ventilation
|
Interventional
|
Not Applicable |
- Colin Grissom
- Intermountain Health Care, Inc.
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient-Level Proportion of time on Mechanical Ventilation with a Tidal Volume <= 6.5 ml/kg PBW
- Proportion of time with a target PaCO2 of 35 to 45 mm Hg
- Average number of protocol deviations for all subjects (protocol compliance)
- (and 8 more...)
|
728 |
All |
18 Years and older (Adult, Older Adult) |
NCT03243539 |
1050582 |
NEUROVENT |
August 31, 2017 |
August 15, 2018 |
December 31, 2018 |
August 9, 2017 |
April 27, 2018 |
|
- Intermountain Medical Center
Murray, Utah, United States
|
|
| 11 |
NCT03141216 |
Recruiting |
Effects of Mechanical Ventilation on Pulmonary Electrical Impedance, Diaphragmatic Mobility and Patient-ventilator Synchrony |
|
- Device: VCV+PSV
- Device: PCV+PSV
|
Interventional
|
Not Applicable |
- Universidade Federal de Pernambuco
- Real Hospital Português de Beneficência em Pernambuco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- electrical impedance measures
- gas blood analysis data
- diaphragmatic mobility
- patient-ventilator synchrony
|
50 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03141216 |
03021991 |
|
March 9, 2017 |
December 31, 2017 |
June 2018 |
May 5, 2017 |
March 20, 2018 |
|
- Hospital Real Português de Beneficência em Pernambuco
Recife, Pernambuco, Brazil
|
|
| 12 |
NCT03288558 |
Recruiting |
Protective Mechanical VENTilation Strategy in Patients Undergoing CARDiac Surgery |
- Pulmonary Complications
- Cardiac Surgery
|
- Other: A comprehensive perioperative mechanical ventilation strategy
|
Interventional
|
Not Applicable |
- University Health Network, Toronto
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Post-operative pulmonary complications
- Ventilator free days
- Intensive care length of stay
- (and 8 more...)
|
310 |
All |
18 Years and older (Adult, Older Adult) |
NCT03288558 |
17-5171 |
|
July 7, 2017 |
October 30, 2019 |
June 1, 2020 |
September 20, 2017 |
September 21, 2017 |
|
- Toronto General Hospital, University Health Network
Toronto, Ontario, Canada
|
|
| 13 |
NCT03231735 |
Recruiting |
Mid and Standard Frequency Ventilation in Infants With Respiratory Distress Syndrome |
- Ventilator-Induced Lung Injury
- Respiratory Distress Syndrome
- Bronchopulmonary Dysplasia
- Preterm Infant
|
- Device: Mid frequency ventilation
- Device: Standard frequency ventilation
|
Interventional
|
Phase 2
Phase 3 |
- University of Alabama at Birmingham
- University of South Alabama
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Alive ventilator free days
- Alive at day 28 after birth
- Ventilator free
- (and 13 more...)
|
130 |
All |
up to 3 Days (Child) |
NCT03231735 |
F160701002 |
MIDAS |
August 2, 2017 |
July 31, 2019 |
July 31, 2019 |
July 27, 2017 |
August 9, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - University of South Alabama
Mobile, Alabama, United States
|
|
| 14 |
NCT03226925 |
Recruiting |
Mechanically-assisted Ventilation in the Treatment of Moving Tumours With Photon and Proton Therapies |
- Thoracic Neoplasm
- Liver Cancer
- Ventilator Lung
- Radiotherapy; Complications
|
- Diagnostic Test: Non-invasive mechanically-assisted ventilation
- Diagnostic Test: Dynamic MRI acquisition
- Diagnostic Test: Planning 4D-CT
|
Interventional
|
Not Applicable |
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Measure in millimeters of the internal motion during non-invasive mechanically assisted ventilation, based on MRI images
- Tolerance assessment
- Internal motion reproducibility with non-invasive mechanically assisted ventilation.
- Dosimetric comparison
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03226925 |
2017/23MAI/294 |
|
June 30, 2017 |
April 30, 2018 |
April 30, 2018 |
July 24, 2017 |
July 24, 2017 |
|
- Cliniques Universitaires Saint-Luc
Brussels, Belgium
|
|
| 15 |
NCT03479047 |
Recruiting |
Diaphragmatic Ultrasound Associated With RSBI Predict Weaning Issue: the Rapid Shallow Diaphragmatic Index (RSDI) |
- Mechanical Ventilation
- Mechanical Ventilator Weaning
- Extubation
- Diaphragm Ultrasound
|
- Diagnostic Test: assess diaphragmatic displacement (DD) using ultrasonography
|
Interventional
|
Not Applicable |
- Centre Hospitalier Régional d'Orléans
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Difference between the RSBI area and the RSDI AUC
- Find a cut-off value for RSDI
- Compare traditional RSBI values recorded with scientific publications
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03479047 |
CHRO-2018-02 |
CODEX |
March 23, 2018 |
March 22, 2019 |
March 22, 2019 |
March 27, 2018 |
April 9, 2018 |
|
- CHR d'Orléans
Orléans, France
|
|
| 16 |
NCT03230617 |
Not yet recruiting |
Dynamic Hyperinflation In Mechanically Ventilated Chronic Obstructive Pulmonary Disease Patients |
- Pulmonary Disease, Chronic Obstructive
|
- Device: Mechanical ventilator
|
Observational
|
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- The duration of mechanical ventilation
|
100 |
All |
Child, Adult, Older Adult |
NCT03230617 |
EDHMVCP |
|
September 1, 2017 |
September 1, 2018 |
December 31, 2018 |
July 26, 2017 |
July 27, 2017 |
|
- Assiut University
Assiut, Egypt
|
|
| 17 |
NCT03303040 |
Recruiting |
Effect of Diaphragm Stimulation During Surgery |
- Mechanical Ventilation Complication
- Diaphragm Injury
|
- Other: Electrical stimulation of hemidiaphragm
|
Interventional
|
Not Applicable |
- University of Florida
- National Institutes of Health (NIH)
- University of Arizona
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Mitochondrial respiration
- Mitochondrial reactive oxygen species production
- Mitochondrial DNA mutation frequency
- (and 25 more...)
|
54 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT03303040 |
IRB201602186-N
1R01AR072328-01 |
|
February 14, 2018 |
June 2021 |
June 2021 |
October 5, 2017 |
September 13, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 18 |
NCT02894879 |
Recruiting |
Effectiveness Of Modified Chest PT Technidue In Pre And Post-Operative Program In Patients Open Heart Surgery |
|
- Device: BreatheMAX®
- Other: Routine treatment
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Incidence of PPCs,
- The duration of breathing with a mode of mechanical ventilator and duration of intubation time
- length of ICU and hospital stay
- Pulmonary function test
|
48 |
All |
20 Years to 80 Years (Adult, Older Adult) |
NCT02894879 |
Effect of modify chest PT |
|
September 2016 |
April 2017 |
April 2017 |
September 9, 2016 |
October 14, 2016 |
|
- Khon Kaen hospital
Maung Khon Kaen, KhonKaen, Thailand
|
|
| 19 |
NCT02680704 |
Recruiting |
Mechanical Ventilation in Severe Brain Injury: The Effect of Positive End Expiratory Pressure on Intracranial Pressure |
- Intracranial Hypertension
- Critical Illness
- Brain Injuries
- (and 3 more...)
|
- Other: PEEP titrated mechanical ventilation
|
Interventional
|
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Association between PEEP and ICP
- Association between transpulmonary pressure and ICP
- Association between PEEP and cerebral hemodynamics
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT02680704 |
2015P000089 |
|
February 2016 |
January 2019 |
January 2019 |
February 11, 2016 |
March 7, 2018 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
|
| 20 |
NCT03372252 |
Recruiting |
Impact of the Inspiratory Cortical Control on the Outcome of the Ventilatory Weaning Test in Patients Intubated in Resuscitation |
- Respiration Disorder
- Respiratory Failure
- Weaning Failure
- (and 2 more...)
|
- Device: Electroencephalography
|
Interventional
|
Not Applicable |
- Poitiers University Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Magnitude of inspiratory premotor potentials
|
70 |
All |
18 Years and older (Adult, Older Adult) |
NCT03372252 |
BRAIN-WEAN |
|
February 21, 2017 |
July 1, 2019 |
January 30, 2020 |
December 13, 2017 |
June 25, 2018 |
|
- university hospital center of Poitiers
Poitiers, Vienne, France
|
|
| 21 |
NCT03574233 |
Recruiting |
Ultrasonography Guided Weaning Protocol Development to Predict Successful Weaning |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Investigation of ultrasound indices associated with the success or failure of mechanical ventilation weaning
- A) In-ICU mortality
- B) In-hospital mortality
- (and 2 more...)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT03574233 |
4-2018-0357 |
|
July 31, 2018 |
May 30, 2019 |
May 30, 2019 |
June 29, 2018 |
June 29, 2018 |
|
- Yonsei University College of Medicine
Seoul, Korea, Republic of
|
|
| 22 |
NCT03120793 |
Recruiting |
ARDS Esophageal Balloon Pressure Changes With Positioning Study |
|
- Device: Esophageal balloon catheter
|
Observational
|
|
- University of North Carolina, Chapel Hill
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Esophageal pressure measurements from upright to prone position
- Change in Esophageal pressure measurements from upright to supine position
- Change in Transmural pressure measurements from upright to prone position
- (and 3 more...)
|
10 |
All |
18 Years and older (Adult, Older Adult) |
NCT03120793 |
17-0135 |
|
May 11, 2017 |
September 20, 2018 |
September 20, 2018 |
April 19, 2017 |
October 26, 2017 |
|
- University of North Carolina, Chapel Hill
Chapel Hill, North Carolina, United States
|
|
| 23 |
NCT03250793 |
Recruiting |
Work of Breathing Description in Neonates With Congenital Diaphragmatic Hernia in NAVA and in Conventional Ventilation. |
- Hernia, DIaphragmatic, Congenital
|
- Device: Physiologic study measuring work of breathing which can be estimated by the esophageal and trans-diaphragmatic pressure-time product obtained by an esophageal transducer
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Work of breathing averaged over 100 consecutive cycles in NAVA ventilation and conventional ventilation
- Patient-ventilator synchronization in NAVA
- Patient-ventilator synchronization in conventional ventilation
- (and 28 more...)
|
12 |
All |
1 Year and older (Child, Adult, Older Adult) |
NCT03250793 |
69HCL17_0429
2017-A02270-53 |
NAVA-DIAPH |
August 1, 2018 |
August 1, 2019 |
August 1, 2019 |
August 16, 2017 |
July 31, 2018 |
|
- Service de Réanimation Néonatale- Hôpital Femme Mère Enfant- Hospices Civils de Lyon
Bron, France
|
|
| 24 |
NCT03167580 |
Recruiting |
REstricted Versus Liberal Positive End-Expiratory Pressure in Patients Without ARDS |
|
- Procedure: restricted PEEP
- Procedure: liberal PEEP
|
Interventional
|
Not Applicable |
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- ZonMw: The Netherlands Organisation for Health Research and Development
- Amphia Hospital
- (and 11 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilation-free days and alive at day 28
- Length of stay
- Mortality
- (and 5 more...)
|
980 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03167580 |
RELAx |
RELAx |
October 26, 2017 |
December 31, 2019 |
March 1, 2020 |
May 30, 2017 |
August 10, 2018 |
|
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Amsterdam, Netherlands - Onze Lieve Vrouwe Gasthuis
Amsterdam, Netherlands - VU Medical Center
Amsterdam, Netherlands - (and 10 more...)
|
|
| 25 |
NCT02354651 |
Recruiting |
Response to Diaphragmatic Pacing in Subjects With Pompe Disease |
|
- Other: Pulmonary function testing
- Other: Resting breathing pattern
- Other: Respiratory muscle endurance test
- (and 4 more...)
|
Observational
|
|
- University of Florida
- Acid Maltase Deficiency Association
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in off-ventilator spontaneous breathing (SB) at Baseline, Day 3, 14, and 180
- Change in Pulmonary Function Test at Day 3, 14, and 180
- Change in Forced expiratory tests at Screening, Baseline, Day 14, and 180
- (and 5 more...)
|
12 |
All |
2 Years to 65 Years (Child, Adult, Older Adult) |
NCT02354651 |
IRB201600161-N
003-2013
1R21HD090752-01 |
|
May 2013 |
February 2019 |
February 2019 |
February 3, 2015 |
April 27, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 26 |
NCT03498807 |
Recruiting |
A Comparison of Optimal PEEP Determination Guided by EIT and Conventional Protective Ventilation Tool in ARDS Patients |
- ARDS
- Acute Respiratory Distress Syndrome
|
- Device: Ventiltor P/V Loop
- Device: Electrical Impedance Tomography
|
Interventional
|
Not Applicable |
- Hui-Ju Hsu
- Far Eastern Memorial Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Mortality rate in the hospital
|
80 |
All |
20 Years to 99 Years (Adult, Older Adult) |
NCT03498807 |
106094-E |
|
August 28, 2017 |
July 31, 2018 |
July 31, 2018 |
April 17, 2018 |
April 17, 2018 |
|
- Far Eastern Memorial Hospital
Taipei county, Banqiao Dist, Taiwan
|
|
| 27 |
NCT02915458 |
Recruiting |
Predictive Analysis Software for Successful Weaning From Ventilator of Patients |
|
|
Observational
|
|
- Chang Gung Memorial Hospital
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Successful weaning from mechanical ventilation
|
188 |
All |
18 Years and older (Adult, Older Adult) |
NCT02915458 |
104-6531B |
|
January 2016 |
December 2018 |
December 2018 |
September 27, 2016 |
July 24, 2018 |
|
- Department of Thoracic Medicine, Chang Gung Memorial Hospital
Taoyuan, Taiwan
|
|
| 28 |
NCT02779998 |
Recruiting |
Prophylactic Non-invasive Ventilation During Surgical Procedure in Rhythmology |
- Cardiac Electrophysiology
- Anesthesia
- Acute Respiratory Failure
|
- Other: non invasive ventilation
- Other: Standard oxygen therapy with facial mask
|
Interventional
|
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Respiratory event
- Occurence of hemodynamic instability
- Respiratory rate
- (and 11 more...)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT02779998 |
38RC15.163 |
VNI-RYTHMO |
January 2017 |
May 2019 |
September 2019 |
May 23, 2016 |
June 4, 2018 |
|
- Grenoble University Hospital
La Tronche, France
|
|
| 29 |
NCT03300648 |
Recruiting |
Treating Brain Swelling in Pediatric Cerebral Malaria |
|
- Other: Mechanical ventilation
- Other: Hypertonic saline
|
Interventional
|
Phase 3 |
- Michigan State University
- Washington University School of Medicine
- University of Maryland
- Children's Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mortality
- Neurodevelopmental disability
|
261 |
All |
6 Months to 12 Years (Child) |
NCT03300648 |
TBS
U01AI126610 |
TBS |
January 8, 2018 |
November 30, 2023 |
November 30, 2023 |
October 3, 2017 |
August 16, 2018 |
|
- Queen Elizabeth Central Hospital
Blantyre, Malawi
|
|
| 30 |
NCT02545803 |
Recruiting |
The Effect of High Frequency Percussive Ventilation on Cerebral Tissue Oxygenation |
- Patients at the Intensive Care Unit (ICU)
|
- Device: Near-Infrared Spectroscopy (NIRS)
|
Interventional
|
Not Applicable |
- Hasselt University
- Ziekenhuis Oost-Limburg
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- The association between HFPV and cerebral oxygen saturation
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT02545803 |
VDR4_ZOL1 |
|
May 2015 |
May 2018 |
May 2018 |
September 10, 2015 |
March 27, 2018 |
|
- Ziekenhuis Oost-Limburg
Genk, Belgium
|
|
| 31 |
NCT03491332 |
Not yet recruiting |
Effect of Heated Breathing Circuit on Intraoperative Core Temperature and Systemic Inflammation After Brain Surgery: a Prospective Randomized Study |
- Patients Scheduled for Brain Surgery
|
- Device: conventional circuit
- Device: conventional humidification circuit
- Device: new humidifaction heat circuit
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- core temperature
- upper airway temperature
- upper airway humidity
- (and 5 more...)
|
117 |
All |
19 Years and older (Adult, Older Adult) |
NCT03491332 |
1-2017-0087 |
|
April 2018 |
February 2019 |
February 2019 |
April 9, 2018 |
April 9, 2018 |
|
|
|
| 32 |
NCT03326414 |
Not yet recruiting |
Influence of Different PEEP Levels and Tidal Volumes on Regional Lung Function |
- Pulmonary Ventilation; Newborn, Abnormal
|
- Procedure: Constant PEEP - low tidal volume
- Procedure: Constant PEEP - high tidal volume
- Procedure: constant tidal volume - low PEEP
- Procedure: constant tidal volume - high PEEP
|
Interventional
|
Not Applicable |
- Universitätsklinikum Hamburg-Eppendorf
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change of "dependent silent spaces" (DSS) and "non-dependent silent spaces" (NSS)
- Oxygenation index
- complinace of the respiratory system
|
40 |
Male |
18 Years and older (Adult, Older Adult) |
NCT03326414 |
ANA-UKE-PV5538 |
|
January 2018 |
April 2018 |
June 2018 |
October 31, 2017 |
October 31, 2017 |
|
- Department of Anaesthesiology Center of Anaesthesiology and Intensive Care Medicine University Medical Center Hamburg-Eppendorf University of Hamburg
Hamburg, Germany
|
|
| 33 |
NCT03079102 |
Recruiting |
Inhaled Nitric Oxide After Out-of-Hospital Cardiac Arrest |
- Heart Arrest, Out-Of-Hospital
|
- Drug: Nitric Oxide
- Drug: Nitrogen
|
Interventional
|
Phase 2 |
- Cameron Dezfulian
- Mallinckrodt
- University of Pittsburgh
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Death or significant neurological or cardiac impairment
- Death
- Cerebral performance category (CPC)
- (and 11 more...)
|
130 |
All |
18 Years and older (Adult, Older Adult) |
NCT03079102 |
PRO16100408 |
iNOOHCA |
August 21, 2017 |
August 20, 2020 |
November 17, 2020 |
March 14, 2017 |
March 29, 2018 |
|
- UPMC Presbyterian Hospital
Pittsburgh, Pennsylvania, United States - UPMC Mercy Hospital
Pittsburgh, Pennsylvania, United States
|
|
| 34 |
NCT03041740 |
Recruiting |
Fluid Filled Lung Oxygenation Assistance Trial |
- Bronchopulmonary Dysplasia
|
- Drug: Perfluorooctylbromide(PFOB)
|
Interventional
|
Early Phase 1 |
- Children's Hospital of Philadelphia
- ADAGP Charitable Foundation dba Auto Dealers CARing for Kids Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of PFOB participants with no treatment-related adverse events as assessed by CTCAE v4.03 toxicity Scale.
- Pulmonary Artery Pressure Response to PFOB
|
20 |
All |
up to 6 Months (Child) |
NCT03041740 |
12-008686 |
FFLOAT |
June 27, 2017 |
July 2019 |
January 2021 |
February 3, 2017 |
August 22, 2017 |
|
- Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
|
|
| 35 |
NCT02566512 |
Recruiting |
Assessment of Cough Strength in Patients With Tracheostomies |
- Mechanical Ventilator Weaning
|
- Other: Tracheostomy cuff inflation.
- Other: Tracheostomy cuff deflation
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Peak expiratory flow rate
|
20 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02566512 |
B2015:068 |
|
September 2015 |
December 2017 |
December 2017 |
October 2, 2015 |
October 27, 2017 |
|
- Health Sciences Centre
Winnipeg, Manitoba, Canada
|
|
| 36 |
NCT03440593 |
Not yet recruiting |
Indirect Calorimetry Usage and Effect in Ventilator-free Days and Muscle Thickness in Septic Ventilated Patients |
- Sepsis
- Critical Illness
- Respiratory Failure
- (and 4 more...)
|
- Other: Caloric delivery will target results of IC measurement.
|
Interventional
|
Not Applicable |
- Baylor Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilator free days (VFD)
- Calorie and protein adequacy
- Change in quadricep muscle thickness
- Change in diaphragm muscle thickness
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03440593 |
Baylor IRB#017-362 |
|
September 2018 |
December 2020 |
December 2020 |
February 21, 2018 |
July 18, 2018 |
|
- Baylor University Medical Center
Dallas, Texas, United States
|
|
| 37 |
NCT02354365 |
Recruiting |
Measuring Lung Pressures in Critically Ill Children Who Are on Mechanical Ventilation |
- Transpulmonary Pressure
- Pressure.Rate Product
- Guide to Mechanical Ventilator Management
- Extubation Readiness
|
- Device: Transpulmonary Pressure measurement
|
Observational
|
|
- Children's Hospital Los Angeles
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Transpulmonary pressure and Pressure rate product
|
60 |
All |
up to 18 Years (Child, Adult) |
NCT02354365 |
13-00370 |
|
February 2014 |
December 2020 |
December 2021 |
February 3, 2015 |
January 25, 2018 |
|
- Children's Hospital Los Angeles
Los Angeles, California, United States
|
|
| 38 |
NCT02598492 |
Recruiting |
Imputation of PaO2 From SaO2 |
- Acute Respiratory Failure
|
- Other: arterial blood gas
|
Observational
|
|
- Brigham and Women's Hospital
- Chinese PLA General Hospital
- Tianjin Nankai Hospital
- (and 13 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To evaluate the relationship between PaO2 and SaO2 among mechanically ventilated patients
- To utilize SF ratios to impute the PF ratios in assessing the respiratory parameter of the SOFA score
|
1000 |
All |
18 Years and older (Adult, Older Adult) |
NCT02598492 |
2015P001945 |
|
September 2015 |
September 2017 |
September 2017 |
November 6, 2015 |
July 17, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - Gansu Provinical Hospital
Lanzhou, Gansu, China - Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China - (and 22 more...)
|
|
| 39 |
NCT02796430 |
Recruiting |
The ICALIC International Multicentric Study |
|
- Other: Time needed to start indirect calorimetry measurement
- Other: Indirect calorimetry measurement
|
Observational
|
|
- University Hospital, Geneva
- European Society of Intensive Care Medicine
- The European Society for Clinical Nutrition and Metabolism
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Time needed to start indirect calorimetry (IC) measurement in Q-NRG compared to currently used calorimeters
- Comparison of energy expenditure(EE) from Q-NRG and currently used calorimeters
- Coefficient of variation (CV) of EE for different mechanical ventilators
- (and 4 more...)
|
343 |
All |
18 Years and older (Adult, Older Adult) |
NCT02796430 |
15-137 |
ICALIC |
September 10, 2017 |
March 31, 2018 |
September 30, 2018 |
June 10, 2016 |
September 12, 2017 |
|
- Division of Cardiac Thoracic Vascular Anesthesia and Intensive Care Medicine
Vienna, Austria - Department of Intensive Care, Vrije Universiteit Brussel
Brussels, Belgium - Critical Care Medicine, Institute for Nutrition Research, Rabin Medical Center, Beilison Hospital
Petah Tikva, Israel - (and 4 more...)
|
|
| 40 |
NCT02687802 |
Recruiting |
Respiratory Mechanics and Patient-ventilator Asynchrony Index in Patients With Invasive Mechanical Ventilation |
- Respiratory Insufficiency
|
- Other: mechanical ventilation
|
Observational
|
|
- University of Sao Paulo General Hospital
- Fundação de Amparo à Pesquisa do Estado de São Paulo
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- asynchrony index
- Clinical signs of patient-ventilator asynchrony
- ventilation free-days
- (and 2 more...)
|
110 |
All |
18 Years and older (Adult, Older Adult) |
NCT02687802 |
2015/19122-4 |
EpiSync |
August 2016 |
October 2018 |
December 2018 |
February 22, 2016 |
May 8, 2018 |
|
- Hospital das Clínicas -HCFMUSP
Sao Paulo, SP, Brazil
|
|
| 41 |
NCT02819141 |
Recruiting |
Self-management of Sedative Therapy by Ventilated Patients |
- Critical Illness
- Anxiety
- Respiratory Failure
|
|
Interventional
|
Phase 2
Phase 3 |
- Mayo Clinic
- University of Minnesota, MN
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in anxiety using the 100mm vertical visual analog scale
- Changes in duration of days receiving mechanical ventilation after study enrollment
- Changes in delirium using the CAM-ICU tool
- (and 2 more...)
|
228 |
All |
18 Years and older (Adult, Older Adult) |
NCT02819141 |
16-000417
R01HL030881 |
|
November 2016 |
April 2021 |
April 2022 |
June 30, 2016 |
May 22, 2018 |
|
- School of Medicine, University of Minnesota
Minneapolis, Minnesota, United States - Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
|
| 42 |
NCT03415529 |
Not yet recruiting |
Impact of Arterial CO2 Tension on Management and Outcome in Patients With Acute Hypoxemic Respirator Failure and ARDS |
- Acute Severe Respiratory Failure
- Acute Respiratory Distress Syndrome
|
|
Observational
|
|
- European Society of Intensive Care Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Incidence
- Severity
- Hypercapnia
- pH ((potential of hydrogen)
|
4500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03415529 |
CO2LUNGSAFE |
CO2 LUNG SAFE |
March 1, 2018 |
September 30, 2018 |
December 30, 2018 |
January 30, 2018 |
January 31, 2018 |
|
|
|
| 43 |
NCT02836899 |
Recruiting |
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction. |
|
- Drug: Nitric Oxide
- Other: Placebo
|
Interventional
|
Phase 3 |
- Massachusetts General Hospital
- Ichinose, Fumito, M.D., Ph.D., Massachusetts General Hospital
- Kenneth, Shelton, M.D., Massachusetts General Hospital
- (and 11 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Acute kidney injury
- AKI severity
- Renal replacement therapy
- (and 7 more...)
|
250 |
All |
18 Years and older (Adult, Older Adult) |
NCT02836899 |
MGH K23
K23HL128882-01 |
MGHK23 |
February 8, 2017 |
December 31, 2020 |
December 31, 2021 |
July 19, 2016 |
March 22, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States
|
|
| 44 |
NCT02025127 |
Recruiting |
A Randomized Controlled Study of Enteral Nutrition in Septic Shock |
|
|
Interventional
|
Not Applicable |
- Medical College of Wisconsin
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Intensive care unit free days
- Ventilator free days
- Mortality
- (and 2 more...)
|
64 |
All |
18 Years and older (Adult, Older Adult) |
NCT02025127 |
19966 |
|
January 2014 |
April 2018 |
April 2018 |
December 31, 2013 |
August 18, 2017 |
|
- Froedtert Hospital
Milwaukee, Wisconsin, United States
|
|
| 45 |
NCT01367951 |
Recruiting |
Treatment of Acute, Unstable Chest Wall Injuries |
- Blunt Injury of Thorax
- Flail Chest
- Chest Wall Injury Trauma
- Rib Fracture
|
- Procedure: Surgical fixation
|
Interventional
|
Not Applicable |
- St. Michael's Hospital, Toronto
- Sunnybrook Health Sciences Centre
- Hamilton Health Sciences Corporation
- (and 4 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilator-free days (VFD)
- Number of days in the Intensive Care Unit (ICU)
- Amount of pain medication administration, converted to oral morphine equivalence
- (and 4 more...)
|
206 |
All |
16 Years to 85 Years (Child, Adult, Older Adult) |
NCT01367951 |
Unstable chest wall injuries |
|
July 2011 |
October 2018 |
December 2020 |
June 7, 2011 |
September 12, 2018 |
|
- St. Michael's Hospital
Toronto, Ontario, Canada
|
|
| 46 |
NCT02643381 |
Recruiting |
Etomidate Versus Ketamine for Emergency Endotracheal Intubation: a Prospective Randomized Clinical Trial |
- Cardiopulmonary Arrest
- Respiratory Arrest
|
- Drug: Etomidate
- Drug: Ketamine
- Procedure: Emergency Endotracheal Intubation
- Device: Mechanical Ventilation
|
Interventional
|
Phase 4 |
- University of Texas Southwestern Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Survival
- Sequential Organ Failure Assessment (SOFA) scores
- Immediate outcomes of endotracheal intubation.
- (and 4 more...)
|
825 |
All |
18 Years and older (Adult, Older Adult) |
NCT02643381 |
022015-023 |
EvK |
June 2016 |
April 2019 |
April 2021 |
December 31, 2015 |
October 30, 2017 |
|
- Parkland Hospital
Dallas, Texas, United States
|
|
| 47 |
NCT03676998 |
Not yet recruiting
New |
Diaphragm Dysfunction During Prolonged Mechanical Ventilation |
- Prolonged Mechanical Ventilation
|
- Device: Measurement of diaphragm function
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Proportion of patients successfully liberated from the ventilator
- Diaphragm function
- Partial liberation from mechanical ventilation
- Proportion of patients with diaphragm dysfunction upon admission and upon discharge
|
90 |
All |
18 Years and older (Adult, Older Adult) |
NCT03676998 |
K171101J
2017-A03091-52 |
DD-SRPR |
September 15, 2018 |
September 15, 2020 |
December 15, 2020 |
September 19, 2018 |
September 19, 2018 |
|
- Pitié-Salpêtrière Hospital
Paris, France
|
|
| 48 |
NCT03436225 |
Not yet recruiting |
Steroid Therapy in Acute Bronchiolitis A New Old Line of Therapy. |
- Bronchiolitis; Respiratory Syncytial Virus
|
- Drug: Dexamethasone orally.
- Drug: Dexamethasone parenteral.
- Drug: Inhaled nebulized Budesonide.
- Drug: Inhaled nebulized salbutamol.
|
Interventional
|
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Resolution of respiratory distress.
- Reduction of mean duration of symptoms.
- Reduction of duration of oxygen therapy.
- Reduction of average Length of hospital stay.
|
80 |
All |
3 Months to 2 Years (Child) |
NCT03436225 |
Steroid in bronchiolitis. |
|
February 2018 |
February 2019 |
March 2019 |
February 16, 2018 |
February 20, 2018 |
|
|
|
| 49 |
NCT03098524 |
Recruiting |
Low Tidal MEChanical Ventilation Against NO Ventilation During Cardiopulmonary Bypass Heart Surgery |
- Respiratory Failure
- Atelectasis
- Pneumonia
- (and 4 more...)
|
- Procedure: Low tidal volume ventilation (LTV arm)
- Procedure: No ventilation (noV arm)
- Procedure: Lung recruitment manoeuver
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- All-cause mortality or early respiratory failure or Late respiratory failure or Ventilator acquired pneumonia and early pneumonia
- All-cause in-hospital mortality
- Early respiratory failure
- (and 5 more...)
|
1500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03098524 |
2016/03 |
MECANO |
May 1, 2017 |
April 15, 2020 |
April 15, 2020 |
March 31, 2017 |
July 6, 2017 |
|
- CMC Ambroise Paré
Neuilly-sur-Seine, Ile-de-France, France
|
|
| 50 |
NCT03506906 |
Not yet recruiting |
The Debated Role of Sleep Studies in Patients Under Established Home Mechanical Ventilation |
- Hypoventilation Syndrome
- Chronic Obstructive Pulmonary Disease
- Obesity Hypoventilation Syndrome
- (and 2 more...)
|
- Diagnostic Test: Sleep studies under noninvasive ventilation therapy
|
Observational
|
|
- Wissenschaftliches Institut Bethanien e.V
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adjustment of non-invasive ventilation
- Non-invasive ventilation compliance
- Health-related quality of life
|
97 |
All |
18 Years and older (Adult, Older Adult) |
NCT03506906 |
WI_18-023 |
|
April 30, 2018 |
May 31, 2019 |
November 30, 2019 |
April 24, 2018 |
April 26, 2018 |
|
|
|
| 51 |
NCT03673683 |
Recruiting
New |
Sedation and Weaning in Children Requiring Invasive Mechanical Ventilation |
|
- Behavioral: SANDWICH protocol
- Behavioral: Usual care
|
Interventional
|
Not Applicable |
- Queen's University, Belfast
- Birmingham Women's and Children's NHS Foundation Trust
- Royal Brompton & Harefield NHS Foundation Trust
- (and 6 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Duration of Invasive Mechanical Ventilation
- Successful Extubation
- Number of unplanned extubations
- (and 12 more...)
|
14310 |
All |
up to 16 Years (Child) |
NCT03673683 |
B17/13
15/04/01 |
SANDWICH |
February 5, 2018 |
October 14, 2019 |
November 11, 2019 |
September 17, 2018 |
September 17, 2018 |
|
- Belfast Health and Social Care Trust
Belfast, Co. Antrim, United Kingdom - Alder Hey Children's NHS Foundation Trust
Liverpool, Merseyside, United Kingdom - University Hospitals of North Midlands NHS Trust
Stoke, Staffordshire, United Kingdom - (and 14 more...)
|
|
| 52 |
NCT02332187 |
Recruiting |
Effect of All-Stim 2 Quadriceps Treatments on Limb Muscle Strength In Mechanically Ventilated Patients |
|
- Device: Active electrical stimulation using an All Stim stimulator
- Device: Sham electrical stimulation using an All Stim stimulator
|
Interventional
|
Not Applicable |
- Gerald Supinski
- University of Kentucky
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Quadriceps Muscle Strength
- Duration of hospitilization
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT02332187 |
Protocol 12-0807-F6A |
|
December 2014 |
September 2018 |
September 2018 |
January 6, 2015 |
May 11, 2018 |
|
- Chandler Hospital
Lexington, Kentucky, United States
|
|
| 53 |
NCT03149640 |
Recruiting |
Study Comparing Inhaled Amikacin Versus Placebo to Prevent Ventilator Associated Pneumonia |
- Pneumonia, Ventilator-Associated
|
- Drug: Inhaled amikacin
- Drug: Inhaled placebo
|
Interventional
|
Phase 3 |
- University Hospital, Tours
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of a first VAP episode from randomization to day 28
- Incidence of a first VAP episode in the subgroups of patients with tracheobronchial colonization or tracheobronchitis
- Incidence of VAP due to Gram negative amikacin sensitive bacteria
- (and 16 more...)
|
850 |
All |
18 Years and older (Adult, Older Adult) |
NCT03149640 |
PHRN15-SE / AMIKINHAL |
AMIKINHAL |
July 19, 2017 |
June 2020 |
June 2020 |
May 11, 2017 |
May 10, 2018 |
|
- Service de Réanimation Chirurgicale
Angers, France - Service de Réanimation Médicale - CH d'Angoulême
Angoulême, France - Service de Réanimation - CH Beauvais
Beauvais, France - (and 17 more...)
|
|
| 54 |
NCT03249623 |
Recruiting |
Individualised Weaning From Mechanical Ventilation in General ICU |
|
- Device: Beacon Caresystem
|
Interventional
|
Not Applicable |
- Chelsea and Westminster NHS Foundation Trust
- Aalborg University
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Length of mechanical ventilation
- Time to spontaneous ventilation
- Time to extubation
|
274 |
All |
18 Years and older (Adult, Older Adult) |
NCT03249623 |
226610
2017-002627-25 |
iCareWean_CW |
December 11, 2017 |
December 30, 2018 |
August 30, 2019 |
August 15, 2017 |
December 13, 2017 |
|
- The Magill Department of Anaesthesia, Chelsea and Westminster Hospital
London, United Kingdom
|
|
| 55 |
NCT03105414 |
Recruiting |
INCIPAVE Study: Incidence of Ventilator Acquired Pneumonia in Children |
- Pneumonia, Ventilator-Associated
|
- Device: Mechanical ventilation
|
Observational
|
|
- Sylvie Chevret
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of ventilator acquired pneumonia
- Bacteria prevalence of ventilator acquired pneumonia
- prevalence of diagnostic devices used to identify ventilator acquired pneumonia
|
2100 |
All |
up to 18 Years (Child, Adult) |
NCT03105414 |
11-362 |
INCIPAVE |
April 3, 2017 |
May 15, 2018 |
May 15, 2019 |
April 10, 2017 |
May 9, 2017 |
|
- Robert Debré Hospital
Paris, France
|
|
| 56 |
NCT02582957 |
Recruiting |
Sigh Ventilation to Increase Ventilator-Free Days in Victims of Trauma at Risk for Acute Respiratory Distress Syndrome |
- Acute Respiratory Distress Syndrome
|
|
Interventional
|
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
- United States Department of Defense
- University of Colorado, Denver
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Ventilator-free days (VFDs)
- All-cause mortality
- ICU-free days
- (and 3 more...)
|
916 |
All |
18 Years to 89 Years (Adult, Older Adult) |
NCT02582957 |
W81XWH-15-1-0504 |
SiVent |
April 2016 |
January 2020 |
January 2020 |
October 21, 2015 |
August 16, 2018 |
|
- UCSF Fresno Community Regional Medical Center
Fresno, California, United States - University of Southern California (LA County)
Los Angeles, California, United States - Stanford University
Palo Alto, California, United States - (and 7 more...)
|
|
| 57 |
NCT02447692 |
Recruiting |
Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study |
- Critically Ill
- Acute Respiratory Failure
|
- Other: PSV ventilation strategy
- Other: PAV+ ventilation strategy
|
Interventional
|
Not Applicable |
- Lawson Health Research Institute
- Canadian Institutes of Health Research (CIHR)
- Medtronic
- Canadian Critical Care Trials Group
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Ventilator Free Days (VFDs) at 21 days post randomization
- Ventilator-free days at 14 and 28 days post randomization
- Time from randomization to successful extubation
- (and 11 more...)
|
512 |
All |
18 Years and older (Adult, Older Adult) |
NCT02447692 |
IPR-327433, ISR-2014-10481 |
PROMIZING |
September 14, 2016 |
September 2019 |
December 2019 |
May 19, 2015 |
April 5, 2018 |
|
- Royal Columbian Hospital
New Westminster, British Columbia, Canada - London Health Sciences Centre - University Hospital
London, Ontario, Canada - Victoria Hospital
London, Ontario, Canada - (and 12 more...)
|
|
| 58 |
NCT03581760 |
Recruiting |
Cycling Exercise in Mechanical Ventilation |
- Muscle Weakness
- Mechanical Ventilation Complication
|
- Other: Cycling Exercise
- Other: Conventional Physiotherapy
|
Interventional
|
Not Applicable |
- University Hospital Ostrava
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of ventilator days
- Muscle strength
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03581760 |
KARIM-08-Motomed
MH CZ - DRO-FNOs/2017 |
|
May 2, 2017 |
November 2020 |
December 2020 |
July 10, 2018 |
July 10, 2018 |
|
- University Hospital Ostrava
Ostrava, Moravian-Silesian Region, Czechia
|
|
| 59 |
NCT03504514 |
Not yet recruiting |
Evaluation of the Effect of a Speech Detection Tool on the Improvement of Phonation in Neuromuscular Patients Dependent on Mechanical Ventilation |
- Neuromuscular Diseases
- Mechanical Ventilation
- Speech
|
- Device: speech trials during different ventilation conditions
- Other: speech trial
|
Interventional
|
Not Applicable |
- Centre d'Investigation Clinique et Technologique 805
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- reading duration
- Vocal flow
- vocal range
- (and 9 more...)
|
28 |
All |
18 Years and older (Adult, Older Adult) |
NCT03504514 |
2017-A00109-44 |
Ventiphono |
August 2018 |
March 2019 |
July 2019 |
April 20, 2018 |
July 17, 2018 |
|
|
|
| 60 |
NCT03245684 |
Not yet recruiting |
Assisted or Controlled Ventilation in Ards (Ascovent) |
- ARDS
- Ventilator-Induced Lung Injury
- Mechanical Ventilation Complication
- Inflammatory Response
|
- Diagnostic Test: assessment of inflammatory response during PSV
|
Interventional
|
Not Applicable |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pulmonary concentration of inflammation mediators (broncho-alveolar lavage: BAL)
- Systemic concentration of inflammation mediators (plasma)
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03245684 |
ASCOVENT |
ASCOVENT |
September 1, 2017 |
September 1, 2019 |
September 1, 2019 |
August 10, 2017 |
August 10, 2017 |
|
|
|
| 61 |
NCT03557645 |
Not yet recruiting |
Ventilator Hyperinflation and Hemodynamics |
- Respiratory Failure
- Respiratory Disorders
|
- Device: Baseline Mechanical Ventilation
- Device: VHI With Inspiratory Pause
- Device: VHI Without Inspiratory Pause
|
Interventional
|
Not Applicable |
- Centro Universitário Augusto Motta
- Universidade Federal do Rio de Janeiro
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Cardiac Output
- Change in Cardiac Index
- Change in Vascular pulmonary resistance
- (and 7 more...)
|
24 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT03557645 |
VHI Hemodynamics |
VHI-HD |
June 4, 2018 |
July 20, 2018 |
July 30, 2018 |
June 15, 2018 |
June 15, 2018 |
|
- Hospital Santa Martha
Niterói, Rio De Janeiro, Brazil
|
|
| 62 |
NCT02390024 |
Recruiting |
Influence of Patient/Ventilador Decoupling in Neurocognitive and Psychopathological Sequelae in ICU Patients |
|
- Device: Invasive Mechanical Ventilation
|
Observational
|
|
- Corporacion Parc Tauli
- Althaia Xarxa Assistencial Universitària de Manresa
- Hospital Mutua de Terrassa
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Short-term neurocognitive alterations
- Long-term neurocognitive alterations
- Short-term anxiety and depression symptoms
- (and 3 more...)
|
150 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02390024 |
PI13/02204 |
PVI-NCOG |
June 2015 |
March 2018 |
September 2018 |
March 17, 2015 |
January 24, 2018 |
|
- Corporación Sanitaria Parc Taulí
Sabadell, Barcelon, Spain
|
|
| 63 |
NCT01769846 |
Recruiting |
The Impact of Early Mobilization Protocol in Patients in the ICU |
- Muscle Weakness
- Quality of Life
- Weaning Acceleration
- (and 2 more...)
|
- Other: Early mobilization protocol
|
Interventional
|
Not Applicable |
- Universidade Federal de Santa Maria
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Muscle thickness (MT) of the quadriceps femoris.
- Muscle thickness (MT) of the diaphragm.
- Rectus femoris cross-sectional area
- (and 11 more...)
|
28 |
All |
18 Years and older (Adult, Older Adult) |
NCT01769846 |
07201712.8.0000.5346 |
|
March 2015 |
September 2018 |
September 2018 |
January 17, 2013 |
March 12, 2018 |
|
- University Hospital of Santa Maria
Santa Maria, Rio Grande Do Sul, Brazil
|
|
| 64 |
NCT03255057 |
Recruiting |
Extracorporeal CO2 Removal With the Hemolung RAS for Mechanical Ventilation Avoidance During Acute Exacerbation of COPD |
- Acute Exacerbation of COPD
|
- Device: Hemolung Respiratory Assist System
- Device: Invasive mechanical ventilation
|
Interventional
|
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- VFD-60
- All-cause in-hospital mortality
- Total and individual incidence of pre-identified critical care safety endpoints (representing primary complication risks of the investigational treatment, the active control treatment, and the severity of illness)
- (and 18 more...)
|
500 |
All |
22 Years and older (Adult, Older Adult) |
NCT03255057 |
HL-CA-5000 |
VENT-AVOID |
February 18, 2018 |
December 2019 |
December 2020 |
August 21, 2017 |
April 20, 2018 |
|
- Abbott Northwestern Hospital
Minneapolis, Minnesota, United States - Albany Medical Center
Albany, New York, United States - Columbia University Medical Center
New York, New York, United States
|
|
| 65 |
NCT03433105 |
Recruiting |
Oxygen Uptake in Weaning of Patients From Prolonged Mechanical Ventilation |
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Measurement of oxygen uptake (V̇O2)
|
200 |
All |
20 Years to 100 Years (Adult, Older Adult) |
NCT03433105 |
201710003RINB |
|
January 23, 2018 |
December 31, 2018 |
December 31, 2018 |
February 14, 2018 |
September 13, 2018 |
|
- National Taiwan University Hospital
Taipei, Taiwan
|
|
| 66 |
NCT03246425 |
Recruiting |
Influence of Mechanical Ventilation Mode on Arterial Pressure Variations- a Pilot Study |
- Blood Pressure
- Critical Illness
- Hypovolemia
|
- Other: Ventilator mode change
- Device: Monitoring of blood pressure variation
|
Interventional
|
Not Applicable |
- State University of New York - Upstate Medical University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- The study is to compare the effects of different modes of mechanical ventilation on arterial pressure variations. The arterial pressure variations will be measured as changes in the Stroke Volume Variation.
- The study is to compare the effects of different modes of mechanical ventilation on arterial pressure variations. The arterial pressure variations will be measured as changes in the Pulse Pressure Variation
- Secondary outcome measured will be the influence of Airway Pressure Release Ventialtion (APRV) on arterial pressure measured using Pulse Pressure Variation
- Secondary outcome measured will be the influence of Airway Pressure Release Ventialtion (APRV) on arterial pressure measured using Stroke Volume variation.
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03246425 |
909804-2 |
|
September 12, 2016 |
September 11, 2017 |
December 31, 2017 |
August 11, 2017 |
August 11, 2017 |
|
- SUNY Upstate Medical University
Syracuse, New York, United States
|
|
| 67 |
NCT03486249 |
Recruiting |
Interaction Diaphragm and Cardiac Function During Ventilator Weaning |
|
- Other: Repetition of medical examinations performed as part of the care
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Failure at the spontaneous breathing trial
- Rate of patients with diaphragm dysfunction
- Rate of patients with weaning induced pulmonary edema
- Rate of patients with diaphragm dysfunction and weaning induced pulmonary edema
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03486249 |
K180103J |
I-DISCO |
April 27, 2018 |
October 30, 2019 |
October 30, 2019 |
April 3, 2018 |
September 6, 2018 |
|
- Groupe Hospitalier Pitié-Salpétrière
Paris, France
|
|
| 68 |
NCT02732041 |
Recruiting |
Asynchrony During Mechanical Ventilation in Patients With Acute Respiratory Distress Syndrome |
- Respiratory Distress Syndrome, Adult
- Ventilator-Induced Lung Injury
|
|
Observational
|
|
- Centro de Educación Medica e Investigaciones Clínicas Norberto Quirno
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Asynchrony index
- Length of mechanical ventilation
- ICU mortality
|
100 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT02732041 |
CEMIC1008 |
|
May 2016 |
October 2018 |
October 2018 |
April 8, 2016 |
June 4, 2018 |
|
- Complejo Medico Churruca Visca
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina - Hospital Italiano de Buenos Aires
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina - Sanatorio Anchorena
Ciudad Autonoma Buenos Aires, Buenos Aires, Argentina - (and 2 more...)
|
|
| 69 |
NCT03108118 |
Recruiting |
Diaphragm Injury and Dysfunction During Mechanical Ventilation |
- Respiratory Insufficiency
- Diaphragm Injury
- Mechanical Ventilation Complication
|
|
Observational
|
|
- University Health Network, Toronto
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diaphragm dysfunction
- Diaphragm thickness
- Diaphragm neuromuscular coupling
- (and 2 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03108118 |
12-5582-B |
MYOTRAUMA |
June 25, 2013 |
December 2018 |
December 2018 |
April 11, 2017 |
July 6, 2018 |
|
- Mount Sinai Hospital
Toronto, Ontario, Canada - University Health Network
Toronto, Ontario, Canada
|
|
| 70 |
NCT03271671 |
Recruiting |
Pressure Support Ventilation (PSV) Versus Neurally Adjusted Ventilator Assist (NAVA) During Acute Respiratory Failure (ARF) |
|
- Other: NAVA during Non invasive ventilation
- Other: PSV during Non invasive ventilation
|
Interventional
|
Not Applicable |
- Postgraduate Institute of Medical Education and Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Rates of NIV failures
- 28-day mortality
- Time to successful weaning
- (and 5 more...)
|
75 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03271671 |
TRB2447/1/7/17 |
|
October 1, 2017 |
October 31, 2018 |
December 31, 2018 |
September 5, 2017 |
December 5, 2017 |
|
- Respiratory ICU, Post Graduate Institue of Medical Education and Research
Chandigarh, India
|
|
| 71 |
NCT03012360 |
Recruiting |
Antimicrobial Treatment in Patients With Ventilator-associated Tracheobronchitis |
- Mechanical Ventilation Complication
- Critical Illness
|
- Drug: ceftriaxone
- Drug: ciprofloxacin
- Drug: imipenem
- (and 2 more...)
|
Interventional
|
Phase 4 |
- University Hospital, Lille
- Ministry of Health, France
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- The percentage of patients with a transition from VAT to VAP,
- duration of mechanical ventilation-free days
- duration of antibiotic free-days
- (and 5 more...)
|
315 |
All |
18 Years and older (Adult, Older Adult) |
NCT03012360 |
2015_66
2016-000735-41 |
TAVeM2 |
February 8, 2018 |
February 2020 |
September 2020 |
January 6, 2017 |
February 14, 2018 |
|
- Hôpital Roger Salengro, CHRU
Lille, France
|
|
| 72 |
NCT03451461 |
Recruiting |
Asynchronies During Mechanical Ventilation |
- Mechanical Ventilation Complication
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence of asynchronies during mechanical ventilation
- Influence of sedation and analgesia in the incidence of asynchronies
- Influence of respiratory mechanics in the incidence of asynchronies
|
1000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03451461 |
Asynchronies |
|
January 2011 |
December 2018 |
December 2018 |
March 1, 2018 |
March 1, 2018 |
|
- candelaria De Haro
Sabadell, Barcelona, Spain
|
|
| 73 |
NCT02330432 |
Recruiting |
Mycobacterium w in Patients With Severe Sepsis |
|
- Biological: Mycobacterium w
- Other: Best standard care
|
Interventional
|
Phase 2
Phase 3 |
- Postgraduate Institute of Medical Education and Research
- Pandit Bhagwat Dayal Sharma, PGIMS, Rohtak
- St.John's National Academy of Health Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Mortality
- New onset organ dysfunction measured by delta SOFA (maximum minus baseline SOFA)
- Ventilator-free days
- (and 4 more...)
|
150 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02330432 |
Pulm/Mw/002 |
MISS |
May 2015 |
January 2019 |
January 2019 |
January 5, 2015 |
August 23, 2018 |
|
- Department of Pulmonary Medicine
Chandigarh, UT, India
|
|
| 74 |
NCT02855619 |
Recruiting |
Comparison of the Impact of Three Programs of Inspiratory Muscles. |
- Weaning From Mechanical Ventilation
|
- Procedure: Martin
- Procedure: Cader
- Procedure: EDRIC
|
Interventional
|
Not Applicable |
- University Hospital, Bordeaux
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Maximal Inspiratory Pressure score (inspiratory muscle strength index) performed by an external electronic device connected with a unidirectional valve.
- Peak Pressure (inspiratory muscle endurance index) performed by an incremental threshold test.
- Duration of the weaning period
- (and 3 more...)
|
88 |
All |
18 Years and older (Adult, Older Adult) |
NCT02855619 |
CHUBX2015/25 |
PREDRIC |
October 15, 2016 |
August 2018 |
September 2018 |
August 4, 2016 |
November 14, 2017 |
|
- Réanimation Médicale
Bordeaux, France - Réanimation Médicale
Lyon, France
|
|
| 75 |
NCT03558737 |
Not yet recruiting |
Nasal High-frequency Jet Ventilation (nHFJV) Following Extubation in Preterm Infants |
- Infant,Premature
- Respiratory Failure
- Respiratory Insufficiency
- Respiratory Distress Syndrome in Premature Infant
|
- Other: Nasal high-frequency jet ventilation (nHFJV)
- Other: Nasal intermittent positive pressure ventilation (NIPPV)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- 72 hour rate of reintubation to invasive mechanical ventilation
- 7 day rate of reintubation to invasive mechanical ventilation
- Total number of days of invasive mechanical ventilation
- Rates of moderate to severe bronchopulmonary dysplasia (BPD)
|
40 |
All |
up to 72 Hours (Child) |
NCT03558737 |
109858 |
|
July 1, 2018 |
May 31, 2019 |
May 31, 2020 |
June 15, 2018 |
June 15, 2018 |
|
- University of Utah
Salt Lake City, Utah, United States - Primary Children's Hospital
Salt Lake City, Utah, United States
|
|
| 76 |
NCT03428737 |
Recruiting |
Impact of a Nocturnal Pressure Controlled Ventilation on Mechanical Ventilation Weaning Duration in Patients With Chronic Obstructive Respiratory Diseases |
- Noctural Ventilatory Mode and Weaning Duration
|
- Procedure: Nocturnal controlled pressure control ventilation
- Procedure: Pressure support ventilation
|
Interventional
|
Not Applicable |
- Centre Hospitalier Universitaire, Amiens
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The percentage of ventilation weaning at Day 4
|
46 |
All |
18 Years and older (Adult, Older Adult) |
NCT03428737 |
PI2017_843_0016 |
REVENTIL 2 |
December 1, 2018 |
January 1, 2021 |
January 1, 2021 |
February 12, 2018 |
September 6, 2018 |
|
|
|
| 77 |
NCT02219659 |
Recruiting |
Pilot Study on Pairing Sedation Strategies and Weaning |
- Acute Respiratory Failure
|
- Drug: Sedation Protocol with Daily Interruption
- Drug: Sedation Protocol Without Daily Interruption
- Drug: Fentanyl Push First
|
Interventional
|
Not Applicable |
- MemorialCare Health System
- Memorial Medical Center Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mechanical ventilation free days
- Duration of weaning
- ICU length of stay
|
90 |
All |
18 Years and older (Adult, Older Adult) |
NCT02219659 |
25613 |
|
April 2014 |
April 2018 |
April 2018 |
August 19, 2014 |
March 29, 2018 |
|
- Long Beach Memorial Medical Center
Long Beach, California, United States
|
|
| 78 |
NCT03613987 |
Recruiting |
Randomized Control Trial: Synchronized Non-invasive Positive Pressure Ventilation Versus Non Synchronized Non Invasive Positive Pressure Ventilation in Extremely Low Birth Weight Infants |
- BPD - Bronchopulmonary Dysplasia
|
- Device: NAVA technology to synchronize NIPPV
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The need for Mechanical Ventilation via ET tube ( MVET) at 7 days of life
- The need for Mechanical Ventilation via ET tube ( MVET) at 28 days of life
- Incidence of BPD or need for supplemental O2 at 36 weeks corrected age
|
60 |
All |
24 Weeks to 30 Weeks (Child) |
NCT03613987 |
L12,175 |
|
April 26, 2018 |
April 26, 2019 |
April 26, 2019 |
August 3, 2018 |
August 15, 2018 |
|
- Westchester Medical Center
Valhalla, New York, United States
|
|
| 79 |
NCT02386683 |
Recruiting |
Intraoperative Lung-Protective Ventilation in Neurosurgery |
- Ventilator-induced Lung Injury
|
- Other: lung-protective ventilation
|
Interventional
|
Not Applicable |
- Capital Medical University
- Beijing Tiantan Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Postoperative pulmonary complications
- Intraoperative brain relaxation.
- The postoperative complications within 30 days
- (and 7 more...)
|
360 |
All |
40 Years to 80 Years (Adult, Older Adult) |
NCT02386683 |
kY2014-031-02 |
|
October 2015 |
March 2018 |
November 2018 |
March 12, 2015 |
October 3, 2017 |
|
- Department of Anesthesiology,Beijing Tiantan Hospital, Capital Medical University
Beijing, Beijing, China
|
|
| 80 |
NCT03360968 |
Recruiting |
Heartrate Variability During Conventional and Variable Pressure Support Mechanical Ventilation |
- Mechanical Ventilation Complication
|
- Procedure: Variable-PS
- Procedure: SPN-CPAP/PS
|
Interventional
|
Not Applicable |
- Medical University of Vienna
- Vienna University of Technology
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- HF components
- SDNN
- HF-LF-ratio
- Tidal volumes
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03360968 |
EK Nr: 1827/2017 |
|
February 6, 2018 |
December 1, 2018 |
December 1, 2018 |
December 4, 2017 |
March 21, 2018 |
|
- Medical University of Vienna
Vienna, Austria
|
|
| 81 |
NCT03527797 |
Recruiting |
Diaphragm Protective Ventilation in the Intensive Care Unit |
- Critical Illness
- Muscle Weakness
- Muscle Damage
- (and 2 more...)
|
- Other: Titration of support level
|
Interventional
|
Not Applicable |
- VU University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Adequate diaphragm loading
- Pressure-time product of diaphragm activity
- Work of breathing
- (and 2 more...)
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03527797 |
NL62486.029.17 |
DiaPro |
May 16, 2018 |
May 30, 2019 |
May 30, 2019 |
May 17, 2018 |
May 17, 2018 |
|
- VU University medical center
Amsterdam, Noord-Holland, Netherlands
|
|
| 82 |
NCT03306524 |
Recruiting |
The Role of Circuit Flow During Mechanical Ventilation of Neonates |
- Respiratory Distress Syndrome in Premature Infant
|
- Device: SIPPV_VG_0_08
- Device: SIPPV_VG_0_16
- Device: SIPPV_VG_0_24
- (and 7 more...)
|
Interventional
|
Not Applicable |
- Cambridge University Hospitals NHS Foundation Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- End tidal CO2 measurement
|
30 |
All |
up to 2 Months (Child) |
NCT03306524 |
16/28 |
E-Flow |
July 1, 2017 |
June 30, 2018 |
June 30, 2018 |
October 11, 2017 |
October 11, 2017 |
|
- Neonatal Intensive Care Unit, Cambridge University Hospitals NHS Trust
Cambridge, United Kingdom
|
|
| 83 |
NCT02753959 |
Recruiting |
Changes in Regional Lung Ventilation Following Mechanical Insufflation-Exsufflation |
|
- Other: Acute Intervention
- Other: Stable Intervention
|
Interventional
|
Not Applicable |
- Guy's and St Thomas' NHS Foundation Trust
- B&D Electromedical
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Reduction in the regional ventilation delays and Increase in homogeneity of ventilation post MIE vs baseline.
- Change in neural respiratory drive (EMGpara) pre to post clearance
- Change in gas exchange (SpO2 and tcCO2)
- Subjective patient comfort (Visual analogue scale - VAS)
|
20 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02753959 |
PM Mar 16 |
MIE and EIT |
August 2016 |
September 2018 |
September 2018 |
April 28, 2016 |
April 11, 2018 |
|
- Guys and St Thomas NHS Foundation
London, United Kingdom
|
|
| 84 |
NCT02539732 |
Recruiting |
Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm |
- Respiratory Insufficiency
|
|
Observational
|
|
- St. Michael's Hospital, Toronto
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in tidal volume after removing a standardized level of NAVA assistance.
- Comparison of Pmusc estimated by an occlusion technique, PVBC, and PEI.
- Change in tidal volume from PEEP of 5 centimeters of water (cmH2O) to zero PEEP.
- Change in EAdi during NAVA mode, CPAP, and after extubation.
|
110 |
All |
18 Years and older (Adult, Older Adult) |
NCT02539732 |
REB# 15-214 |
OWED |
September 2015 |
December 2018 |
December 2018 |
September 3, 2015 |
April 12, 2018 |
|
- St. Michael's Hospital
Toronto, Ontario, Canada - Centre Hospitalier Universitaire Angers
Angers, France - Azienda Ospedaliero - Universitaria OORR Ospedali Riuniti di Foggia
Foggia, Italy
|
|
| 85 |
NCT03267693 |
Not yet recruiting |
Gastrointestinal Complications in Association With Oropharyngeal and Respiratory Infections in Mechanical Ventilation |
- Ventilator Associated Pneumonia
|
- Diagnostic Test: Gastric and oropharyngeal PH
|
Observational
|
|
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- measurement of gastric and oropharyngeal ph in mechanically ventilated patients
|
100 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03267693 |
Gastrointestinal tract and VAP |
|
September 2017 |
September 2018 |
October 2018 |
August 30, 2017 |
August 30, 2017 |
|
|
|
| 86 |
NCT03614845 |
Not yet recruiting |
Evaluation of Effect of Different Ventilator Mods on Atelectasis in Patients Undergoing Laparoscopic Surgery |
- Atelectasis
- Atelectases, Postoperative Pulmonary
|
- Procedure: VCV
- Procedure: PCV-VG
- Diagnostic Test: lung ultrasonography
|
Interventional
|
Not Applicable |
- Derince Training and Research Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Effect of different ventilation mods on development of peroperative atelectasis
|
60 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03614845 |
DerinceTRH-006 |
PCV-VG |
September 1, 2018 |
December 30, 2018 |
December 30, 2018 |
August 3, 2018 |
August 23, 2018 |
|
|
|
| 87 |
NCT03188770 |
Recruiting |
Practice of Ventilation in Middle-Income Countries |
- Mechanical Ventilation
- Respiratory Distress Syndrome, Adult
- Acute Respiratory Failure
|
|
Observational
|
|
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Mahidol Oxford Tropical Medicine Research Unit
- Hospital Israelita Albert Einstein
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Tidal volume size
- Positive end-expiratory pressure
- Patients at risk of ARDS
- (and 14 more...)
|
3000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03188770 |
PRoVENT-iMIC |
PRoVENT-iMIC |
November 1, 2017 |
December 2018 |
December 2018 |
June 15, 2017 |
June 19, 2018 |
|
- Chittagong Medical College Hospital
Chittagong, Bangladesh - Bangabandhu Sheikh Mujib Medical University
Dhaka, Bangladesh - BIRDEM General Hospital
Dhaka, Bangladesh - (and 33 more...)
|
|
| 88 |
NCT02801994 |
Recruiting |
Impact of Proportional Assisted Ventilation on Dyspnea and Asynchrony in Mechanically Ventilated Patients |
|
- Device: PAV, Puritan Bennett 980 ventilator
|
Interventional
|
Not Applicable |
- Association pour le Développement et l'Organisation de la Recherche en Pneumologie et sur le Sommeil
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Quantification of dyspnea
- Airway pressure
- Electromyography (EMG) of extra inspiratory diaphragmatic muscles
- (and 4 more...)
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT02801994 |
ADOREPS_1 |
DYS-PAV |
February 24, 2016 |
October 2019 |
October 2019 |
June 16, 2016 |
December 22, 2017 |
|
- Service de Pneumologie et Réanimation Médicale, Groupe Hospitalier Pitié Salpêtrière
Paris, France
|
|
| 89 |
NCT03453944 |
Recruiting |
NMES to Prevent Respiratory Muscle Atrophy in Mechanically Ventilated Patients |
- Mechanical Ventilation Complication
- Neuromuscular Electrical Stimulation
- Muscle Weakness
|
- Device: VentFree prototype (VF03-K) active stimulation
- Device: VentFree prototype (VF03-K) sham stimulation
|
Interventional
|
Not Applicable |
- University Medical Center Nijmegen
- Liberate Medical
- VU University Medical Center
- Canisius-Wilhelmina Hospital
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Thickness of the abdominal wall muscles
- Thickness of the diaphragm
- Thickness of the rectus abdominis muscle
- (and 7 more...)
|
20 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03453944 |
LM-RB-01 |
|
March 9, 2017 |
July 1, 2018 |
December 31, 2018 |
March 5, 2018 |
March 5, 2018 |
|
- UMC Nijmegen
Nijmegen, Gelderland, Netherlands - Canisius Wilhelmina Hospital
Nijmegen, Gelderland, Netherlands - VU University Medical Center
Amsterdam, Noord-Holland, Netherlands
|
|
| 90 |
NCT03330379 |
Not yet recruiting |
Comparison of Two Strategies for Endotracheal Tube Cuff Underinflation Prevention During Invasive Mechanical Ventilation |
- Acute Brain Injury
- Brain Injuries
|
- Device: Tracoe Smart CuffmanagerTM
|
Interventional
|
Not Applicable |
- Nantes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Incidence of underinflation episodes
- incidence of Pcuff >30 cmH2O measurements (overinflation episodes)
- Duration of mechanical ventilation
- (and 3 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03330379 |
RC16_0390 |
CONTIPRESS |
November 2017 |
January 2019 |
January 2019 |
November 6, 2017 |
November 6, 2017 |
|
|
|
| 91 |
NCT02877498 |
Recruiting |
A Study to Compare Adaptive Support Ventilation vs. Volume Controlled Ventilation for Management of Respiratory Failure in Patients With Neuroparalytic Snake Envenomation |
- Snake Envenomation
- Invasive Mechanical Ventilation
- Adaptive Support Ventilation
|
- Other: Adaptive support ventilation
- Other: Volume controlled ventilation
|
Interventional
|
Not Applicable |
- Postgraduate Institute of Medical Education and Research
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Liberation from mechanical ventilation
- Incidence of ventilator associated pneumonia
- Post extubation respiratory failure
- (and 2 more...)
|
50 |
All |
12 Years to 90 Years (Child, Adult, Older Adult) |
NCT02877498 |
NK/2194/Study/1241(168) |
ASV vs VCV in |
August 2016 |
August 31, 2018 |
December 31, 2018 |
August 24, 2016 |
September 1, 2017 |
|
- Respiratory ICU, Post Graduate Institue of Medical Education and Research
Chandigarh, India
|
|
| 92 |
NCT03372174 |
Recruiting |
Maintaining Mechanical Ventilation During Cardiopulmonary Bypass for Cardiac Surgery |
|
- Device: Maintaining mechanical ventilation during surgery
- Device: Absence of mechanical ventilation during surgery
|
Interventional
|
Not Applicable |
- Rennes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Incidence of postoperative infections
- Expression of human leukocyte antigen-DR antigen (HLA-DR)
- Plasmatic concentration of interleukin 10 (IL10)
- (and 10 more...)
|
1400 |
All |
18 Years and older (Adult, Older Adult) |
NCT03372174 |
35RC16_9908_VECAR
2017-A01246-47 |
VECAR |
January 10, 2018 |
February 10, 2020 |
August 10, 2020 |
December 13, 2017 |
March 20, 2018 |
|
- CHU Angers
Angers, France - CHU Bordeaux
Bordeaux, France - CHU Lille
Lille, France - (and 3 more...)
|
|
| 93 |
NCT03140267 |
Recruiting |
Assessment of Inspiratory Muscles Strength and Endurance Evolution on Difficult to Wean Patients in Intensive Care Unit |
- Weaning From Mechanical Ventilation
|
- Diagnostic Test: Difficult to wean patients
|
Interventional
|
Not Applicable |
- University Hospital, Bordeaux
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Maximal Inspiratory Pressure score assessment
- Peak Pressure assessment
- Maximal Inspiratory Pressure score assessment after weaning success
- (and 4 more...)
|
80 |
All |
18 Years and older (Adult, Older Adult) |
NCT03140267 |
CHUBX 2015/37 |
EFES |
May 14, 2017 |
April 14, 2019 |
May 14, 2019 |
May 4, 2017 |
November 14, 2017 |
|
- Hôpital Haut-Lévêque
Bordeaux, France - Hôpital Pellegrin
Bordeaux, France
|
|
| 94 |
NCT03642002 |
Recruiting |
The Effects of Music Therapy on Adult Patients Requiring Mechanical Ventilation in the ICU |
- Acute Respiratory Distress Syndrome
- Acute Hypoxemic Respiratory Failure
- Acute Hypercapnic Respiratory Failure
|
- Other: Toning
- Other: Ocean drum & SOK melody
- Other: SOK
- (and 2 more...)
|
Interventional
|
Not Applicable |
- Icahn School of Medicine at Mount Sinai
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Cumulative Length of Time on Ventilator
- Cumulative Length of Stay in Hospital
- Respiration Rate
- (and 9 more...)
|
178 |
All |
18 Years and older (Adult, Older Adult) |
NCT03642002 |
GCO 18-1079 |
|
September 2018 |
September 2020 |
January 2021 |
August 22, 2018 |
August 22, 2018 |
|
- Mount Sinai West
New York, New York, United States
|
|
| 95 |
NCT03434821 |
Recruiting |
Hyperoxemia and Ventilator-associated Pneumonia |
|
|
Observational
|
|
- University Hospital, Lille
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- VAP occurrence
- percentage of time spent with hyperoxemia during ICU stay
- relationship between hyperoxemia at ICU admission and the presence of acute lung injury (ALI)
- percentage of time spent with hyperoxemia during ICU stay, and the presence of acute lung injury
|
534 |
All |
18 Years and older (Adult, Older Adult) |
NCT03434821 |
2016_73
2017-A01934-49 |
SOH-VAP |
February 5, 2018 |
February 2020 |
September 2020 |
February 15, 2018 |
February 15, 2018 |
|
- CHU de Lille
Lille, France
|
|
| 96 |
NCT01731795 |
Recruiting |
Efficacy Study of Dexamethasone to Treat the Acute Respiratory Distress Syndrome |
- Acute Respiratory Distress Syndrome
|
|
Interventional
|
Phase 4 |
- Dr. Negrin University Hospital
- Fundación Mutua Madrileña
- Asociación Científica Pulmón y Ventilación Mecánica
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Ventilator free-days
- Mortality
|
314 |
All |
Child, Adult, Older Adult |
NCT01731795 |
2012-000775-17 |
DEXA-ARDS |
April 2013 |
October 2018 |
October 2018 |
November 22, 2012 |
August 1, 2018 |
|
- Hospital Universitario Dr. Negrin
Las Palmas de Gran Canaria, Spain - Hospital Clinico de Valencia
Valencia, Spain
|
|
| 97 |
NCT02644005 |
Recruiting |
Automated Control of Mechanical Ventilation During General Anaesthesia |
|
- Device: Smart Vent Control
|
Observational
|
|
- University of Schleswig-Holstein
- Drägerwerk AG & Co. KGaA
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Frequency of adverse events.
- Frequency of normoventilated, hypoventilated and hyperventilated patients.
- Time period between switch from controlled ventilation to augmented ventilation and achievement of stable assisted ventilation of the patient.
- (and 8 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT02644005 |
AVAS |
AVAS |
July 7, 2017 |
December 31, 2018 |
January 31, 2019 |
December 31, 2015 |
May 3, 2018 |
|
- University Hospital St. Pölten, Department of Anesthesiology and Intensive Care Medicine
St. Pölten, Austria - University Medical Center Schleswig-Holstein, Campus Kiel, Department of Anesthesiology and Intensive Care Medicine
Kiel, Germany
|
|
| 98 |
NCT02259335 |
Recruiting |
Weaning Form Mechanical Ventilation Using Extracorporeal CO2 Removal |
- Patients With Acute Hypercapnic Respiratory Failure
|
- Device: Extracorporeal CO2 removal device
|
Interventional
|
Not Applicable |
- Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
- University of Turin, Italy
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- passing a weaning trial using a T-piece method
- weaning success
- Physiological variables (i.e. Arterial Blood Gases, vitals and dyspnea)
|
15 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02259335 |
110/2014 |
WeanPRO |
October 2014 |
April 2017 |
October 2017 |
October 8, 2014 |
October 11, 2016 |
|
- San'Orsola Malpighi Hospital, Bologna ITALY
Bologna, Italy - AOU Città della Salute e della Scienza di Torino, Molinette Hospital
Turin, Italy
|
|
| 99 |
NCT02875379 |
Recruiting |
Clinical Comparison of Different Humidification Strategies During Noninvasive Ventilation With Helmet |
|
|
Interventional
|
Not Applicable |
- Catholic University of the Sacred Heart
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Comfort assessed by visual analogic scale modified for ICU patients
- Patient-ventilator asynchrony. Asynchrony index
- Work of breathing. Oesophageal pressure time product
- (and 6 more...)
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT02875379 |
11491/15 |
|
February 1, 2017 |
December 1, 2018 |
February 1, 2019 |
August 23, 2016 |
August 2, 2018 |
|
- General ICU, A. Gemelli hospital
Rome, Italy
|
|
| 100 |
NCT03314701 |
Recruiting |
Mechanical Ventilation in Multiple Fracture Ribs |
|
- Device: Biphasic Intermittent Positive Airway Pressure (BIPAP)
- Device: Airway Pressure Release Ventilation (APRV)
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Duration of mechanical ventilation
- Resting Energy Expenditure
- Physiological dead space
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03314701 |
IRB0000879659 |
|
October 25, 2017 |
October 2018 |
December 2018 |
October 19, 2017 |
July 9, 2018 |
|
- Faculty of Medicine
Assiut, Egypt
|
|
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