46 studies found for:    mannkind
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Rank Status Study
1 Withdrawn Single Site, Single Subject, Treatment IND With Mannkind Corporation's Technosphere Inhalation System
Condition: Diabetes
Intervention: Drug: Technosphere® Insulin Inhalation System
2 Completed A 2-Month Safety Follow-Up Trial
Conditions: Type 1 Diabetes;   Type 2 Diabetes
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Comparator
3 Completed
Has Results
Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Technosphere Insulin;   Drug: Metformin & Secretagogues;   Drug: Technosphere Insulin & Metformin
4 Completed Feasibility Study Using Zone-MPC Controller, HMS and Technosphere® Insulin Inhalation System From MannnKind Corp
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Investigational inhaled insulin (Technosphere);   Device: Artificial Pancreas (AP) device (APS©)
5 Completed A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention: Drug: Technosphere®/Insulin
6 Completed Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
Conditions: Mild Nephropathy;   Moderate Nephropathy;   Diabetes Mellitus
Intervention: Drug: Technosphere Inhalation Powder
7 Completed Vaccine Therapy in Treating Patients With Stage IV Melanoma
Condition: Melanoma (Skin)
Intervention: Biological: Synchrotope TA2M
8 Completed Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Rapid Acting Analog
9 Completed A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: MKC253 Inhalation Powder;   Drug: Technosphere Inhalation Powder;   Drug: subcutaneous injection
10 Terminated Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma
Conditions: Stage III Melanoma;   Stage IV Melanoma
Intervention: Biological: MKC1106-MT
11 Completed A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
Conditions: Asthma;   Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Salbutamol (Albuterol);   Drug: Methacholine chloride
12 Completed A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Receiving Insulin Glargine
Condition: Diabetes Mellitus, Type 1
Intervention: Drug: Technosphere Insulin
13 Completed Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
Condition: Healthy
Interventions: Drug: Technosphere Insulin Inhalation Powder using the Gen2C inhaler;   Drug: Regular Human Insulin
14 Completed A Trial to Determine How Long Insulin and FDKP (the Molecule That Forms Technosphere Particles) Stays in the Lungs of Healthy Individuals After Inhalation of Technosphere® Insulin (TI) Powder Using Bronchoalveolar Lavage (BAL)
Condition: Healthy Subjects
Intervention: Drug: TI Inhalation Powder
15 Completed Vaccine Therapy in Treating Patients With Stage IV Melanoma
Condition: Melanoma (Skin)
Intervention: Biological: MKC1106-MT
16 Completed Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Mellitus
Condition: Diabetes Type 2
Intervention: Drug: Technosphere Insulin
17 Terminated Evaluate Safety of TI in Diabetic Subjects With Moderate Obstructive Pulmonary Disease (Asthma and COPD)
Conditions: Diabetic Type 1 With Asthma or COPD;   Diabetic Type 2 With Asthma or COPD;   Type 1 Diabetes;   Type 2 Diabetes;   Indeterminate Obstructive Lung Disease
Interventions: Drug: Technosphere Insulin;   Drug: Usual Care
18 Completed A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult Males
Conditions: Diabetes Mellitus, Type 2;   Healthy Males
Intervention: Drug: MKC253 Inhalation Powder
19 Completed
Has Results
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Condition: Type 2 Diabetes Mellitus
Intervention: Drug: Technosphere® Insulin Inhalation Powder and MedTone™ Inhaler
20 Completed A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy Volunteers
Conditions: Diabetes Mellitus;   Healthy Subjects
Interventions: Drug: Technosphere Insulin (TI) Inhalation Powder;   Drug: Albuterol (Salbutamol);   Drug: Fluticasone

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Indicates status has not been verified in more than two years