46 studies found for:    mannkind
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Rank Status Study
1 Withdrawn Single Site, Single Subject, Treatment IND With Mannkind Corporation's Technosphere Inhalation System
Condition: Diabetes
Intervention: Drug: Technosphere® Insulin Inhalation System
2 Completed A 2-Month Safety Follow-Up Trial
Conditions: Type 1 Diabetes;   Type 2 Diabetes
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Comparator
3 Completed
Has Results
Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Technosphere Insulin;   Drug: Metformin & Secretagogues;   Drug: Technosphere Insulin & Metformin
4 Completed Feasibility Study Using Zone-MPC Controller, HMS and Technosphere® Insulin Inhalation System From MannnKind Corp
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Investigational inhaled insulin (Technosphere);   Device: Artificial Pancreas (AP) device (APS©)
5 Completed A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention: Drug: Technosphere®/Insulin
6 Completed Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Rapid Acting Analog
7 Completed Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
Condition: Healthy
Interventions: Drug: Technosphere Insulin Inhalation Powder using the Gen2C inhaler;   Drug: Regular Human Insulin
8 Terminated Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma
Conditions: Stage III Melanoma;   Stage IV Melanoma
Intervention: Biological: MKC1106-MT
9 Completed A Trial to Determine How Long Insulin and FDKP (the Molecule That Forms Technosphere Particles) Stays in the Lungs of Healthy Individuals After Inhalation of Technosphere® Insulin (TI) Powder Using Bronchoalveolar Lavage (BAL)
Condition: Healthy Subjects
Intervention: Drug: TI Inhalation Powder
10 Completed
Has Results
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Condition: Type 2 Diabetes Mellitus
Intervention: Drug: Technosphere® Insulin Inhalation Powder and MedTone™ Inhaler
11 Completed A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy Volunteers
Conditions: Diabetes Mellitus;   Healthy Subjects
Interventions: Drug: Technosphere Insulin (TI) Inhalation Powder;   Drug: Albuterol (Salbutamol);   Drug: Fluticasone
12 Completed A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
Conditions: Asthma;   Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Salbutamol (Albuterol);   Drug: Methacholine chloride
13 Terminated Evaluate Safety of TI in Diabetic Subjects With Moderate Obstructive Pulmonary Disease (Asthma and COPD)
Conditions: Diabetic Type 1 With Asthma or COPD;   Diabetic Type 2 With Asthma or COPD;   Type 1 Diabetes;   Type 2 Diabetes;   Indeterminate Obstructive Lung Disease
Interventions: Drug: Technosphere Insulin;   Drug: Usual Care
14 Completed A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: MKC253 Inhalation Powder;   Drug: Technosphere Inhalation Powder;   Drug: subcutaneous injection
15 Completed Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
Conditions: Mild Nephropathy;   Moderate Nephropathy;   Diabetes Mellitus
Intervention: Drug: Technosphere Inhalation Powder
16 Completed Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Mellitus
Condition: Diabetes Type 2
Intervention: Drug: Technosphere Insulin
17 Completed A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Receiving Insulin Glargine
Condition: Diabetes Mellitus, Type 1
Intervention: Drug: Technosphere Insulin
18 Completed 18-Week, Randomized, Double-blind, Placebo Controlled, Forced Titration Study of Patients With Type 2 Diabetes
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Technosphere Insulin;   Drug: Technosphere Placebo
19 Completed A First in Human, Single Dose, Safety and Tolerability Study of MKC253 Inhalation Powder in Healthy Adult Males
Conditions: Diabetes Mellitus, Type 2;   Healthy Males
Intervention: Drug: MKC253 Inhalation Powder
20 Completed Vaccine Therapy in Treating Patients With Stage IV Melanoma
Condition: Melanoma (Skin)
Intervention: Biological: MKC1106-MT

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Indicates status has not been verified in more than two years