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48 studies found for:    mannkind
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Rank Status Study
1 Withdrawn Single Site, Single Subject, Treatment IND With Mannkind Corporation's Technosphere Inhalation System
Condition: Diabetes
Intervention: Drug: Technosphere® Insulin Inhalation System
2 Completed A 2-Month Safety Follow-Up Trial
Conditions: Type 1 Diabetes;   Type 2 Diabetes
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Comparator
3 Completed Vaccine Therapy in Treating Patients With Stage IV Melanoma
Condition: Melanoma (Skin)
Intervention: Biological: MKC1106-MT
4 Completed
Has Results
Efficacy and Safety of Prandial Inhalation of Technosphere/Insulin in Combination With Metformin or Technosphere/Insulin Alone Versus 2 Oral Anti-Diabetic Agents in Subjects With Type 2 Diabetes
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Technosphere Insulin;   Drug: Metformin & Secretagogues;   Drug: Technosphere Insulin & Metformin
5 Completed Feasibility Study Using Zone-MPC Controller, HMS and Technosphere® Insulin Inhalation System From MannnKind Corp
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Investigational inhaled insulin (Technosphere);   Device: Artificial Pancreas (AP) device (APS©)
6 Completed Safety and Immune Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma.
Conditions: Advanced Melanoma;   Stage III and IV Melanoma
Interventions: Biological: Biological: MKC1106-MT;   Biological: Biological: MKCC1106-MT
7 Completed A Study to Evaluate Insulin in the Blood After Inhalation of a Dry Powder Insulin Formulation (Called Technosphere®/Insulin) in Non-diabetic Patients With & Without Chronic Obstructive Pulmonary Disease (COPD)
Condition: Chronic Obstructive Pulmonary Disease (COPD)
Intervention: Drug: Technosphere®/Insulin
8 Completed Comparison of Technosphere Insulin Inhalation Powder & Subcutaneous Rapid-Acting Analog in Subjects With Type 1 Diabetes
Condition: Type 1 Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Rapid Acting Analog
9 Completed Healthy Normal Volunteers Looking at Exposure and Effects of Multiple Doses of Technosphere® Insulin (TI) Using the Gen2C Inhaler
Condition: Healthy
Interventions: Drug: Technosphere Insulin Inhalation Powder using the Gen2C inhaler;   Drug: Regular Human Insulin
10 Terminated Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma
Conditions: Stage III Melanoma;   Stage IV Melanoma
Intervention: Biological: MKC1106-MT
11 Completed A Trial to Determine How Long Insulin and FDKP (the Molecule That Forms Technosphere Particles) Stays in the Lungs of Healthy Individuals After Inhalation of Technosphere® Insulin (TI) Powder Using Bronchoalveolar Lavage (BAL)
Condition: Healthy Subjects
Intervention: Drug: TI Inhalation Powder
12 Completed
Has Results
An Open-label, Multi-center, International, Three-year, Safety and Tolerability 'Follow on' Trial
Condition: Type 2 Diabetes Mellitus
Intervention: Drug: Technosphere® Insulin Inhalation Powder and MedTone™ Inhaler
13 Completed A Study Designed to Determine if the Drugs Albuterol (Salbutamol) and Fluticasone Have an Effect on the Pharmacokinetics of the Investigational Product Technosphere® Insulin Inhalation Powder in Healthy Volunteers
Conditions: Diabetes Mellitus;   Healthy Subjects
Interventions: Drug: Technosphere Insulin (TI) Inhalation Powder;   Drug: Albuterol (Salbutamol);   Drug: Fluticasone
14 Completed A Study Designed to Determine if the Pharmacokinetic Disposition of Inhaled Insulin Exposure is the Same for Asthmatics and Non-asthmatics
Conditions: Asthma;   Diabetes Mellitus
Interventions: Drug: Technosphere Insulin Inhalation Powder;   Drug: Salbutamol (Albuterol);   Drug: Methacholine chloride
15 Terminated
Has Results
Evaluate Safety of Technosphere® Insulin (TI) in Diabetic Subjects With Moderate Obstructive Pulmonary Disease
Conditions: Type 1 Diabetes Mellitus;   Type 2 Diabetes Mellitus;   Moderate Chronic Obstructive Pulmonary Disease;   Asthma
Interventions: Drug: Technosphere® Insulin;   Drug: Usual Care
16 Completed A Study Designed to Determine the Safety and Pharmacological Response ofMKC253 Inhalation Powder in Adults With Type 2 Diabetes Mellitus
Condition: Diabetes Mellitus, Type 2
Interventions: Drug: MKC253 Inhalation Powder;   Drug: Technosphere Inhalation Powder;   Drug: subcutaneous injection
17 Completed Single Dose, Single Administration Study of Technosphere Inhalation Powder in Diabetic Subjects With Mild or Moderate Kidney Disease Compared to Diabetic Subjects With Normal Kidney Function
Conditions: Mild Nephropathy;   Moderate Nephropathy;   Diabetes Mellitus
Intervention: Drug: Technosphere Inhalation Powder
18 Completed Comparison Between Technosphere/Insulin Inhalation Powder Versus Rapid Acting Insulin in Subjects With Type 2 Diabetes Mellitus
Condition: Diabetes Type 2
Intervention: Drug: Technosphere Insulin
19 Completed A 3 Month, Randomized, Open Label, Multi-center Study of Technosphere/Insulin Compared to Insulin Aspart in Subjects With Type 1 Diabetes Mellitus Receiving Insulin Glargine
Condition: Diabetes Mellitus, Type 1
Intervention: Drug: Technosphere Insulin
20 Completed 18-Week, Randomized, Double-blind, Placebo Controlled, Forced Titration Study of Patients With Type 2 Diabetes
Condition: Type 2 Diabetes Mellitus
Interventions: Drug: Technosphere Insulin;   Drug: Technosphere Placebo

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Study has passed its completion date and status has not been verified in more than two years.