| 1 |
NCT03313999 |
Recruiting |
Measuring Skin Elasticity in Lymphedema Patients |
- Diagnoses Disease
- Lymphedema
|
- Device: Lymphedema Indentometer
|
Interventional |
Not Applicable |
- Beth Israel Deaconess Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
2000 |
All |
18 Years and older (Adult, Senior) |
NCT03313999 |
2017P-000378 |
|
February 18, 2018 |
December 2027 |
December 2027 |
October 19, 2017 |
March 8, 2018 |
|
- Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
| 2 |
NCT03465930 |
Recruiting |
Histologic Analysis of the Lymphatic Vessels Used for Supermicrosurgical Lymphatico-venous Anastomoses in Lymphedema |
|
- Procedure: Supermicrosurgical lymphatico-venous anastomoses
|
Observational |
|
- Paolo Gennaro
- Elisabetta Weber, MD
- University of Siena
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Expression of the lymphatic endothelial marker D2-40 in relation with the duration of lymphedema.
- Area of the vessel wall versus area of the lumen
- The relative proportion of smooth muscle cells and collagen fibers in the lymphatic vessel wall.
- (and 3 more...)
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03465930 |
LVA2017 |
s-LVA |
June 1, 2017 |
December 31, 2018 |
December 31, 2023 |
March 15, 2018 |
March 15, 2018 |
|
- Dept. of Maxillofacial Surgery, Azienda Ospedaliera Universitaria Senese
Siena, Italy
|
| 3 |
NCT02743858 |
Recruiting |
Lymphedema Surveillance Study |
|
- Other: Bilateral arm measurements
- Other: Body mass index (BMI)
- Behavioral: Quality of Life Questionnaire
|
Observational |
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- number of incidences of lymphedema
|
700 |
Female |
18 Years and older (Adult, Senior) |
NCT02743858 |
16-220 |
|
April 2016 |
April 2018 |
April 2018 |
April 19, 2016 |
November 1, 2017 |
|
- Memorial Sloan Kettering Basking Ridge
Basking Ridge, New Jersey, United States - Memorial Sloan Kettering Monmouth
Middletown, New Jersey, United States - Memorial Sloan Kettering Commack
Commack, New York, United States - (and 3 more...)
|
| 4 |
NCT02574780 |
Completed |
Lymphedema Upper Limb of Breast Cancer Through Muscle Strengthening Associated With Complex Physical Therapy |
|
- Other: complex physical therapy
- Other: Evaluate treatment of lymphedema, with in the quality of life and depression
|
Interventional |
Phase 2
Phase 3 |
- Federal University of São Paulo
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Result of complex physical therapy associated with muscle strength protocol
|
42 |
Female |
18 Years and older (Adult, Senior) |
NCT02574780 |
FUSaoPaulo,PT 1 |
LTP |
April 2014 |
December 2015 |
July 2016 |
October 14, 2015 |
October 10, 2016 |
|
- Brazil Federal University São Paulo
São Paulo, SP, Brazil
|
| 5 |
NCT02170272 |
Terminated |
Home-Based Lymphedema Care Program (HBLCP) in Improving Lymphedema Self-Care in Head and Neck Cancer Survivors |
- Head and Neck Cancer
- Lymphedema
|
- Behavioral: Home-based Lymphedema Care Program
|
Interventional |
Not Applicable |
- Vanderbilt-Ingram Cancer Center
- National Cancer Institute (NCI)
- Vanderbilt Office of Clinical and Translational Scientist Development
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in severity rate of head and neck lymphedema
- Change in rating of severity symptom burden
- Change in rating of jaw, neck, and shoulder range of motion
|
20 |
All |
21 Years and older (Adult, Senior) |
NCT02170272 |
VICC HN 1431
NCI-2014-00867
P30CA068485 |
|
June 2014 |
March 2015 |
October 2017 |
June 23, 2014 |
January 25, 2018 |
|
- Vanderbilt-Ingram Cancer Center
Nashville, Tennessee, United States
|
| 6 |
NCT02073045 |
Terminated |
Intensive Education in Increasing Understanding of Lymphedema in Patients With Breast Cancer Undergoing Surgery |
|
- Other: educational intervention
- Other: lymphedema survey
|
Interventional |
Not Applicable |
- Case Comprehensive Cancer Center
- National Cancer Institute (NCI)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Improvement in participant's knowledge of lymphedema
- Total girth differences as assessed by BUE circumferential measurements using the National Lymphedema Network (NLN) guidelines
|
17 |
All |
18 Years and older (Adult, Senior) |
NCT02073045 |
CASE1113
NCI-2014-00348
CASE 1113
P30CA043703 |
|
August 2013 |
September 2015 |
September 2015 |
February 27, 2014 |
October 23, 2015 |
|
- Case Comprehensive Cancer Center
Cleveland, Ohio, United States
|
| 7 |
NCT03391206 |
Completed |
Bioelectrical Impedance Utilization and Dietary Intake Relation in the Breast Cancer Related Lymphedema |
- Breast Cancer Lymphedemas
|
- Diagnostic Test: Inbody 720
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Brest cancer related lymphedema
- BIA
- SFBIA ratio
- (and 4 more...)
|
228 |
Female |
20 Years and older (Adult, Senior) |
NCT03391206 |
4-2016-0149 |
|
April 18, 2016 |
April 18, 2017 |
August 17, 2017 |
January 5, 2018 |
January 5, 2018 |
|
- Yonsei University College of Medicine
Seoul, Korea, Republic of
|
| 8 |
NCT03292198 |
Not yet recruiting |
Subclinical Lymphedema Treatment Study |
- Breast Cancer-related Subclinical Lymphedema
|
- Other: 20-30 mmHg compression sleeve and gauntlet
- Other: Manual Lymphatic Drainage
|
Interventional |
Not Applicable |
- Mercy Research
- Mercy Foundation
- St. Louis Men's Group Against Cancer
- (and 2 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
267 |
Female |
18 Years and older (Adult, Senior) |
NCT03292198 |
1070741-1 |
SLT |
April 2018 |
April 2022 |
December 2022 |
September 25, 2017 |
March 27, 2018 |
|
|
| 9 |
NCT02748746 |
Not yet recruiting |
Early Detection of Lymphedema With Bio-Electrical Impedance Analysis in Patients After Breast Cancer Surgery |
|
- Device: Bio Impedance Analysis Measurement
- Device: Tissue Dielectric Constant Measurement
|
Interventional |
Not Applicable |
- Abant Izzet Baysal University
- Tubitak
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Investigation of early detection of lymphedema after breast cancer surgery with Bio Electrical Impedance Analysis (BIA)
- Investigation of symptom related quality of life with LymQoL
|
60 |
Female |
18 Years to 65 Years (Adult) |
NCT02748746 |
AbantIBU |
BIA |
August 2018 |
May 2019 |
November 2019 |
April 22, 2016 |
February 26, 2018 |
|
- Abant Izzet Baysal University
Bolu, City Centre, Turkey
|
| 10 |
NCT02981485 |
Recruiting |
Fat Grafting Used for the Treatment of Breast Cancer Related Lymphedema in China |
|
|
Interventional |
Phase 2 |
- Peking Union Medical College
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in arm volume
- Change in tissue edema
- The function of the lymphatic vessel
- (and 2 more...)
|
30 |
Female |
20 Years to 60 Years (Adult) |
NCT02981485 |
CZ2015009 |
FGTBRCL |
December 2016 |
January 2018 |
January 2019 |
December 5, 2016 |
December 6, 2016 |
|
- Plastic Surgery Hospital of Chinese Academy of Medical Sciences, Peking Union Medical College
Shijingshan, Beijing, China
|
| 11 |
NCT02912767 |
Active, not recruiting |
Prevalence of Self Reported Lymphedema in Patients With Endometrial Cancer |
- Endometrial Cancer
- Lymphedema
|
- Behavioral: questionnaire
|
Observational |
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- compare lymphedema prevalence
|
625 |
Female |
18 Years and older (Adult, Senior) |
NCT02912767 |
16-1001 |
|
July 20, 2016 |
July 2018 |
July 2018 |
September 23, 2016 |
July 12, 2017 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 12 |
NCT00757406 |
Completed |
Assessment of Unilateral Lymphoedema of the Leg |
|
|
Observational |
|
|
Industry |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- That the L-Dex U400 detects Unilateral leg lymphedema in subjects with the condition and does not detect it in subjects without the condition.
|
45 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00757406 |
UQLDEX02 |
|
August 2008 |
December 2008 |
January 2009 |
September 23, 2008 |
April 16, 2009 |
|
- Qld Lymphoedema and Breast Oncology Physiotherapy
Brisbane, Queensland, Australia
|
| 13 |
NCT02458391 |
Withdrawn |
Complete Decongestive Therapy in Breast Cancer-Related Lymphedema |
|
- Other: Standard of care complete decongestive therapy
|
Interventional |
Not Applicable |
- University of Indianapolis
- Novacare
- Midwestern University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in impairments in function, activity limitations, and participation restrictions
- Changes from baseline in symptoms associated with lymphedema
- Changes from baseline in lymphedema volume
|
0 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT02458391 |
UIndianapolis |
|
July 2015 |
July 2015 |
July 2015 |
June 1, 2015 |
August 7, 2015 |
|
|
| 14 |
NCT00944944 |
Completed |
Gynecologic Cancer Lymphedema Questionnaire as a Clinical Care Tool to Identify Lower Extremity Lymphedema |
- Ovarian Cancer
- Uterine Cancer
- Vaginal Cancer
- Lymphedema
|
- Behavioral: limb volume measurements and GCLQ lymphedema symptom assessment questionnaire
- Behavioral: GCLQ lymphedema symptom assessment questionnaire
|
Observational |
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To determine if the Gynecologic Cancer Lymphedema Questionnaire (GCLQ)tools detects lower extremity lymphedema symptoms in gynecologic cancer survivors & if it is a feasible assessment tool which can be used in the clinical care setting.
|
58 |
Female |
21 Years and older (Adult, Senior) |
NCT00944944 |
09-077 |
|
July 2009 |
January 2010 |
January 2010 |
July 23, 2009 |
February 1, 2010 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 15 |
NCT02611557 |
Recruiting |
Lymphedema Progression Screening Using MRI |
|
- Procedure: Manual lymphatic drainage therapy
|
Interventional |
Not Applicable |
- Vanderbilt University
- Vanderbilt University Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
|
90 |
Female |
18 Years and older (Adult, Senior) |
NCT02611557 |
Donahue_Lymphedema |
INFORM |
February 2015 |
March 2018 |
June 2018 |
November 23, 2015 |
February 17, 2017 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States - Vanderbilt University
Nashville, Tennessee, United States
|
| 16 |
NCT02284373 |
Terminated |
Randomized Clinical Trial of Pneumatic Compression Device for the Treatment of Venous Ulcers and Lymphedema |
|
- Other: Flexitouch for 1 month in addition to routine wound care
- Other: Routine wound care for venous ulcers and lymphedema
- Device: Flexitouch pneumonic compression
|
Interventional |
Not Applicable |
- New York University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To assess quality of life in patients with lymphedema and venous ulcers using CIVIQ-2 self questionnaire
|
85 |
All |
18 Years and older (Adult, Senior) |
NCT02284373 |
11-01568 |
|
May 2011 |
September 2014 |
October 2014 |
November 6, 2014 |
January 11, 2017 |
|
|
| 17 |
NCT02966327 |
Active, not recruiting |
Effect of Early Compression and Exercise on Lymphedema Incidence in Patients With Gynecological Cancer |
- Genital Neoplasms, Female
- Lymphedema
|
- Device: Bilateral leg compression stockings
- Behavioral: Individualized exercise
- Behavioral: Lymphedema risk reduction
|
Interventional |
Not Applicable |
- McGill University Health Center
- Jewish General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Change in bilateral lower limb volume
- Change in bilateral lower limb extracellular fluid volume
- Quality of life
- Incidence of cellulitis
|
50 |
Female |
18 Years and older (Adult, Senior) |
NCT02966327 |
A11-M104-14B |
|
June 2015 |
December 2018 |
March 2019 |
November 17, 2016 |
March 21, 2018 |
|
- McGill University Health Centre Lymphedema Support Centre
Montreal, Quebec, Canada
|
| 18 |
NCT02369679 |
Completed |
Effectiveness of Two Compression Methods in the Treatment of Upper Limb Lymphedema |
|
- Device: Precast Adjustable Compression Wrap (Circaid)
- Device: Multilayer Compression Bandages
|
Interventional |
Not Applicable |
- Parc de Salut Mar
- Hospital Universitari de Bellvitge
- Germans Trias i Pujol Hospital
- Hospital Vall d'Hebron
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Change in the excess of volume of upper limb
- Changes in pain, heaviness, tightness and hardness
- Changes in skin and lymphedema condition
- Number of Participants with Serious and Non-Serious Adverse Events
|
47 |
Female |
18 Years and older (Adult, Senior) |
NCT02369679 |
2014/5584/I |
|
October 13, 2014 |
January 19, 2016 |
April 5, 2017 |
February 24, 2015 |
April 7, 2017 |
|
- Germans Trias i Pujol Hospital
Badalona, Barcelona, Spain - Hospital Universitari de Bellvitge
Hospitalet de Llobregat, Barcelona, Spain - Hospital Vall Hebron
Barcelona, Spain
|
| 19 |
NCT02650297 |
Completed |
The Effect of Combined Decongestive Therapy and Pneumatic Compression Pump on Body Image in Patients With Lymphedema |
|
- Other: combined decongestive therapy
- Device: pneumatic compression pump
|
Interventional |
Phase 1
Phase 2 |
- badri jaafari
- Islamic Azad University, Kazeroun
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- changes in the body image
|
42 |
Female |
35 Years to 70 Years (Adult, Senior) |
NCT02650297 |
IAUKazeroun |
|
October 2009 |
November 2009 |
December 2009 |
January 8, 2016 |
January 8, 2016 |
|
|
| 20 |
NCT02895724 |
Active, not recruiting |
Hyperbaric Oxygen Therapy to Reduce Lymphedema After Breast Cancer -an Explorative Clinical Trial |
|
|
Interventional |
Phase 2 |
- Danish Cancer Society
- Rigshospitalet, Denmark
- Herlev Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Arm volume
- lymph clearance
- Functional impairment
- (and 2 more...)
|
20 |
Female |
18 Years to 75 Years (Adult, Senior) |
NCT02895724 |
H-16019587 |
HBOT-LYCA |
September 2016 |
December 2018 |
December 2018 |
September 12, 2016 |
February 7, 2018 |
|
|
| 21 |
NCT00282529 |
Terminated |
Identification of a Screening Tool and Treatment of Lymphedema Secondary to the Management of Breast Cancer Study |
|
- Device: High Risk Lymphedema Education and Device Intervention
|
Interventional |
Not Applicable |
- Sidney Kimmel Comprehensive Cancer Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Bilateral arm measurements, Lymphedema and Breast Cancer Questionnaire, Disability of the Arm and Shoulder and Hand(DASH)Questionnaire
- Standard lymphedema risk reduction education, Lymphedema prevention
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT00282529 |
J05101 |
|
January 2006 |
November 2007 |
November 2007 |
January 26, 2006 |
January 24, 2017 |
|
- Avon Breasts Center, Johns Hopkins Medical Institutions
Baltimore,, Maryland, United States
|
| 22 |
NCT00376597 |
Active, not recruiting
Has Results |
Education With or Without Exercise and Counseling in Preventing Lymphedema in Women With Stage I, Stage II, or Stage III Breast Cancer Who Are Undergoing Axillary Lymph Node Dissection |
|
- Other: quality of life assessment
- Other: educational intervention
- Procedure: Physical therapy
|
Interventional |
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Number of Participants Who Were Lymphedema-free 18 Months After Randomization
- Change From Baseline at 18 Months in Arm Circumference at the Site of Greatest Difference
- Agreement Between Patients' Self-report of Swelling and the Extent of Circumferential Measurement Difference Between the Treated Side and the Contralateral Arm
- (and 2 more...)
|
568 |
Female |
18 Years and older (Adult, Senior) |
NCT00376597 |
CALGB-70305
CDR0000494652
NCI-2009-00488
U10CA037447 |
|
June 2006 |
November 2015 |
December 2018 |
September 15, 2006 |
October 2, 2017 |
October 2, 2017 |
- East Bay Radiation Oncology Center
Castro Valley, California, United States - Valley Medical Oncology Consultants - Castro Valley
Castro Valley, California, United States - Cancer Care Center at John Muir Health - Concord Campus
Concord, California, United States - (and 73 more...)
|
| 23 |
NCT02979184 |
Active, not recruiting |
Prevalence of Obstructive Sleep Apnea (OSA) in Patients With Lymphedema, Admitted for Intensive Decongestive Physiotherapy |
- Lymphedema
- Obstructive Sleep Apnea Syndrome
|
- Other: Intensive decongestive physiotherapy
|
Interventional |
Not Applicable |
- University Hospital, Grenoble
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Prevalence of obstructive sleep apnea syndrom in patients with lymphedema, admitted for intensive decongestive physiotherapy.
- Effect of intensive decongestive physiotherapy on the severity of the obstructive sleep apnea syndrom of patients with apnea/hypopnea index ≥ 5
- Evolution of clinical signs associated with sleep apnea after rehabilitation
- (and 5 more...)
|
45 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02979184 |
38RC16.204 |
LYMPHOS |
November 2016 |
November 2017 |
January 2019 |
December 1, 2016 |
April 18, 2018 |
|
|
| 24 |
NCT03250364 |
Active, not recruiting |
Compression Bandages in Upper Limb Lymphedema |
|
- Device: Multilayer bandage
- Device: Double compression bandage
- Device: Cohesive bandage
- (and 5 more...)
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in arm volume
- Change in heath related quality of life lymphedema
- Change in comfort of the bandage
|
100 |
Female |
20 Years to 70 Years (Adult, Senior) |
NCT03250364 |
18/2010 |
CB-ULL |
December 2009 |
September 2017 |
October 2017 |
August 15, 2017 |
August 15, 2017 |
|
|
| 25 |
NCT02318615 |
Not yet recruiting |
Immediate Axillary Plasty With a Pedicled Muscle Flap for Breast Cancer Related Lymphedema Prevention |
- Lymphedema
- Breast Neoplasm
|
- Procedure: Immediate Axillary Plasty
|
Interventional |
Not Applicable |
- Peking University People's Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of lymphedema and/or severity of lymphedema
- Shoulder Mobility
- Postoperation seroma
- Acute Upper limb thrombosis
|
450 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT02318615 |
AxLD
PKUPHBR001 |
|
December 2015 |
August 2018 |
August 2020 |
December 17, 2014 |
November 20, 2015 |
|
|
| 26 |
NCT03428581 |
Not yet recruiting |
Preventing Lymphedema in Axillary Lymph Node Dissection |
|
- Procedure: ALND with ARM +/- LVB
- Procedure: ALND
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Less than 5% limb volume increase in the study extremity compared to baseline and the control extremity
- Less frequently reported symptoms of lymphedema in the study extremity compared to baseline and the control extremity
|
264 |
Female |
18 Years and older (Adult, Senior) |
NCT03428581 |
16-010491 |
|
April 1, 2018 |
February 1, 2021 |
February 1, 2023 |
February 9, 2018 |
February 9, 2018 |
|
- Mayo Clinic in Florida
Jacksonville, Florida, United States - Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 27 |
NCT03492476 |
Recruiting
New |
Circaid® Compression Sleeve Versus Short-stretching Bandage in Upper Limb Lymphatic Edema |
|
- Device: Circaid
- Device: Short-stretching Bandage (Reference treatment)
|
Interventional |
Not Applicable |
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Volume reduction of upper limb lymphatic edema D30
- Volume reduction of upper limb lymphatic edema D5
- Volume reduction of upper limb lymphatic edema D90
- (and 15 more...)
|
140 |
Female |
18 Years and older (Adult, Senior) |
NCT03492476 |
C1512 |
|
September 8, 2017 |
December 2018 |
March 2019 |
April 10, 2018 |
April 10, 2018 |
|
- Polyclinique Bordeaux Nord Aquitaine
Bordeaux, France - Chu Saint Eloi
Montpellier, France - Ghr Mulhouse Sud Alsace
Mulhouse, France - Hopital Cognacq Jay
Paris, France
|
| 28 |
NCT03051776 |
Completed |
Kinesio Taping Versus Compression Garments for Breast Cancer-Related Lymphedema |
|
- Other: Kinesio Taping
- Other: Compression Garment
|
Interventional |
Not Applicable |
- Violeta Pajero Otero
- Hospital Universitario 12 de Octubre
- University of Castilla-La Mancha
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Estimated volumen of the upper limb.
- Symptoms associated with BCRL (pain, heaviness, pressure and hardness) using modified visual analogue scale (VAS).
- Goniometry of Upper Limb.
|
30 |
Female |
18 Years and older (Adult, Senior) |
NCT03051776 |
InveCuidRhKM |
|
January 3, 2016 |
March 30, 2016 |
March 30, 2016 |
February 14, 2017 |
October 6, 2017 |
|
- Hospital Universitario 12 de Octubre
Madrid, Spain
|
| 29 |
NCT02927496 |
Not yet recruiting |
A 24 Month Study, to Compare the Efficacy of Doxycycline vs. Placebo for Improving Filarial Lymphedema in Mali |
- Lymphedema
- Lymphatic Filariasis
- Filariasis
|
- Drug: Doxycycline
- Drug: Placebo
|
Interventional |
Phase 3 |
- The Task Force for Global Health
- United States Agency for International Development (USAID)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Lymphedema
- Change in number of acute attacks
|
250 |
All |
14 Years to 65 Years (Child, Adult) |
NCT02927496 |
LeDoxy2015_Mali |
LeDoxy-Mali |
August 15, 2017 |
December 15, 2019 |
December 15, 2019 |
October 7, 2016 |
July 21, 2017 |
|
|
| 30 |
NCT00214032 |
Completed |
Pycnogenol for the Treatment of Lymphedema |
|
- Drug: Pycnogenol
- Drug: Placebo
|
Interventional |
Phase 2 |
- University of Wisconsin, Madison
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- reduction of arm lymphedema
- comparison/validation of bioelectric impedance to measure lymphedema changes, validation of lymphedema questionnaire
|
2 |
Female |
18 Years and older (Adult, Senior) |
NCT00214032 |
2005-0047
NCCAM R21 A1724-01
CC 05302 |
|
May 2002 |
November 2006 |
January 2007 |
September 21, 2005 |
October 5, 2015 |
|
- University of Wisconsin
Madison, Wisconsin, United States
|
| 31 |
NCT02994771 |
Active, not recruiting |
A Phase I Study With Lymfactin® in the Treatment of Patients With Secondary Lymphedema |
|
- Drug: Lymfactin® [1 x 10E10 vp]
- Drug: Lymfactin® [1 x 10E11 vp]
|
Interventional |
Phase 1 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Safety as measured by number of patients with treatment related adverse events and serious adverse events as assessed by CTCAE v4.0
- Volume difference between the treated arm and untreated arm comparing volume measurements at baseline out to one year post treatment
|
15 |
Female |
18 Years to 70 Years (Adult, Senior) |
NCT02994771 |
CL12001 |
|
June 2016 |
March 2019 |
March 2024 |
December 16, 2016 |
February 23, 2018 |
|
- Toeoeloe Hospital, Department of Plastic Surgery
Helsinki, Finland - Tampere University Hospital, Department of Plastic Surgery
Tampere, Finland - Turku University Hospital, Department of Plastic Surgery
Turku, Finland
|
| 32 |
NCT01914276 |
Completed |
Lymphedema in Endometrial Cancer |
- Lower Extremity Lymphedema
- Endometrial Cancer
|
|
Observational |
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- change in incidence of lower-extremity lymphedema
- change in lymphedema-related morbidity
|
100 |
Female |
18 Years and older (Adult, Senior) |
NCT01914276 |
Pro00047483 |
|
October 2013 |
June 2017 |
|
August 2, 2013 |
June 23, 2017 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
| 33 |
NCT02734979 |
Recruiting |
Prospective Evaluation of the Biobridge Scaffold as an Adjunct to Lymph Node Transfer for Upper Extremity Lymphedema |
|
- Device: Biobridge and lymph node transfer
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Limb volume reduction
- Serial lymphoscintigraphy
- Bioimpedance spectroscopy
- (and 3 more...)
|
60 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02734979 |
37161 |
Biobridge |
April 2016 |
May 2019 |
January 2020 |
April 12, 2016 |
April 25, 2017 |
|
- Stanford University
Stanford, California, United States
|
| 34 |
NCT01068431 |
Completed |
Short Term Effectiveness Study of Juxta-Fit Versus Trico Bandages in the Treatment of Leg Lymphedema |
|
- Other: bandaging with trico as active controller
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Efficacy of a device initial made for the maintenance treatment phase, which is now used in the initial treatment phase during 24 hour
- Quality of life (Visual Analog Scale) and number of self-management interventions by the patient in the study group
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT01068431 |
NS2NL |
|
February 2010 |
August 2011 |
August 2011 |
February 15, 2010 |
December 5, 2012 |
|
- Nij Smellinghe hospital
Drachten, Friesland, Netherlands
|
| 35 |
NCT03333226 |
Recruiting |
Axillary Reverse Mapping (ARM) in Breast Cancer Surgery to Prevent Lymphedema. (ARMtrial) |
|
- Procedure: Axillary Reverse Mapping (ARM)
|
Interventional |
Not Applicable |
- University Hospital of Ferrara
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of Breast Cancer Related Lymphedema (BCRL) after Axillary Lymph Node Dissection (ALND)
- Incidence of Breast Cancer Related Lymphedema (BCRL) after Sentinel Lymph Node Biopsy (SLNB) alone
- Crossover between Sentinel Lymph Node (SLN) of the Breast and the ARM lymph node
- Lymphoscintigraphic sub-clinical modifications of arm lymphatic drainage after ALND
|
300 |
Female |
18 Years and older (Adult, Senior) |
NCT03333226 |
RF-2013-02358165 |
|
January 17, 2018 |
December 2020 |
December 2020 |
November 6, 2017 |
January 23, 2018 |
|
- Azienda Ospedaliero Universitaria S. Anna
Cona, Ferrara, Italy
|
| 36 |
NCT01003951 |
Completed |
Acupuncture for the Treatment of Chronic Lymphedema |
|
|
Interventional |
Phase 2 |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To obtain preliminary evidence of the effects of acupuncture on chronic lymphedema due to breast cancer treatment.
- To further evaluate the safety of acupuncture in this setting.
- To obtain preliminary evidence of systemic immune changes that occur after acupuncture treatment of lymphedema.
|
37 |
Female |
18 Years and older (Adult, Senior) |
NCT01003951 |
09-136 |
|
October 2009 |
August 2012 |
August 2012 |
October 29, 2009 |
August 16, 2012 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 37 |
NCT03051750 |
Completed |
Comparison of Techniques for Breast Cancer-Related Lymphedema. |
|
- Other: Complex Physical Therapy plus Pressotherapy
- Other: Kinesio Taping
|
Interventional |
Not Applicable |
- Violeta Pajero Otero
- Hospital Universitario 12 de Octubre
- University of Castilla-La Mancha
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in the volume difference between the upper limb with lymphedema and the healthy upper limb before and after treatment.
- Score on the DASH Outcome Measure.
- Score of the TTDL questionnaire.
- (and 4 more...)
|
42 |
Female |
18 Years and older (Adult, Senior) |
NCT03051750 |
InveCuidRh150316 |
|
February 1, 2016 |
December 21, 2016 |
December 21, 2016 |
February 14, 2017 |
May 2, 2017 |
|
- Hospital Universitario 12 de Octubre
Madrid, Spain
|
| 38 |
NCT01706081 |
Completed |
Acupuncture for Chronic Lymphedema |
- Breast Cancer With Chronic Lymphedema
|
- Procedure: Acupuncture
- Procedure: Wait-list
|
Interventional |
Phase 2 |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- difference in the extent of lymphedema
- effectiveness
- differences between treatment group for bioimpedance
- safety
|
83 |
Female |
18 Years and older (Adult, Senior) |
NCT01706081 |
12-210 |
|
October 2012 |
April 11, 2018 |
April 11, 2018 |
October 15, 2012 |
April 17, 2018 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 39 |
NCT02167659 |
Recruiting |
Bioimpedance Spectroscopy Versus Tape Measure in Prevention of Lymphedema (PREVENT) |
|
- Device: 23-32 mmHg compression sleeve with gauntlet
|
Interventional |
Not Applicable |
- ImpediMed Limited
- Vanderbilt University
- Macquarie University, Australia
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Rate of progression of lymphedema
- Number of participants with risk factors associated with lymphedema.
- Time elapsed between identification of increasing fluid and referral out of study for continued swelling.
- Number of participants with improved skin condition, symptoms and quality of life.
|
1100 |
All |
18 Years and older (Adult, Senior) |
NCT02167659 |
VICCBRE1438 |
|
June 2014 |
December 2020 |
December 2020 |
June 19, 2014 |
February 16, 2018 |
|
- Mayo Clinic
Jacksonville, Florida, United States - University of Kansas Medical Center
Kansas City, Kansas, United States - University of Louisville
Louisville, Kentucky, United States - (and 7 more...)
|
| 40 |
NCT03248310 |
Recruiting |
A Study Comparing Quality of Life in Patients With Lymphedema Who Undergo Surgical Treatment Versus Non-Surgical Management |
|
- Behavioral: Quality of Life Assessments
|
Observational |
|
- Memorial Sloan Kettering Cancer Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
300 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03248310 |
17-377 |
|
August 9, 2017 |
August 2022 |
August 2022 |
August 14, 2017 |
March 16, 2018 |
|
- Memorial Sloan Kettering Westchester
Harrison, New York, United States - Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
| 41 |
NCT02550951 |
Unknown † |
Utility of MR Lymphangiography in Postoperative Follow-up of Lymphedema: Comparison With Lymphoscintigraphy |
|
- Procedure: lymphangiography
|
Interventional |
Not Applicable |
- Seoul National University Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- pattern of lymph drainage (Scale of 0 to 5)
- delay of lymph drainage (Scale of 0 to 10)
- depiction of lymph vessels (Scale of 0 to 10)
- (and 2 more...)
|
7 |
All |
20 Years and older (Adult, Senior) |
NCT02550951 |
D-1408-124-607 |
|
October 2014 |
October 2016 |
October 2016 |
September 16, 2015 |
September 16, 2015 |
|
- Seoul National University Hospital
Seoul, Korea, Republic of
|
| 42 |
NCT02528539 |
Recruiting |
Prevention of Lymphedema Among Breast Cancer Patients Through Implementation of an Integrative Therapy Program (ITP) |
|
|
Interventional |
Not Applicable |
- Huntington Memorial Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Bioimpedance (L-dex U400)
- Arm circumference measurements of the upper limbs using at 4 cm interval
- Self-Efficacy Scale
- (and 3 more...)
|
30 |
Female |
18 Years and older (Adult, Senior) |
NCT02528539 |
HMH2015.002 |
|
August 2013 |
December 2017 |
December 2018 |
August 19, 2015 |
September 21, 2016 |
|
- Huntington Memorial Hospital
Pasadena, California, United States
|
| 43 |
NCT01748604 |
Completed |
Physical Therapies in the Decongestive Treatment of Lymphedema |
- Primary Lymphedema
- Secondary Lymphedema
|
- Other: Manual Lymphatic Drainage (MLD)
- Device: Generic intermittent pneumatic compression Device (IPC)
- Other: multilayer, multicomponent bandages (MB)
- Device: Lymphapress-Plus(TM) device (LPD)
|
Interventional |
Not Applicable |
- Isabel Forner-Cordero, MD, PhD.
- Hospital Universitario La Fe
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage reduction in Excess Volume (PREV)
- the Percentage of Volume reduction (PRV)
|
194 |
All |
18 Years and older (Adult, Senior) |
NCT01748604 |
HULaFe-LYMPHEDEMA-04 |
|
February 2004 |
January 2010 |
June 2012 |
December 12, 2012 |
December 18, 2012 |
|
- University Hospital La Fe
Valencia, Spain
|
| 44 |
NCT02992782 |
Recruiting |
Decongestive Exercise and Compression for Breast Cancer Related Lymphedema Management |
- Breast Neoplasm
- Lymphedema
|
- Behavioral: Standard Care
- Behavioral: Exercise and Compression Garment
- Behavioral: Exercise and Adjustable Compression Wrap
|
Interventional |
Not Applicable |
- University of Alberta
- Cross Cancer Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Arm Lymphedema Volume
- Bioimpedance Analysis
- Upper body strength
- (and 7 more...)
|
24 |
Female |
18 Years and older (Adult, Senior) |
NCT02992782 |
HREBA - CC 16-1026 |
DREAM |
April 15, 2017 |
July 1, 2018 |
September 30, 2018 |
December 14, 2016 |
April 10, 2018 |
|
- University of Alberta/ Cross Cancer Institute
Edmonton, Alberta, Canada
|
| 45 |
NCT02506530 |
Unknown † |
Treatment Pathway of Patients Suffering From a Breast Cancer Related Lymphoedema, During an Intensive Decongestive Treatment |
|
- Procedure: intensive decongestive treatment
- Device: Cellu M6
|
Interventional |
Not Applicable |
- University Hospital, Toulouse
- LPG SYSTEMS
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The proportion of patients successfully treated (reduction of the excessive volume in the arm>30%)
- Progression of the excessive volume in the arm since hospitalization
- assess adverse effects
|
93 |
Female |
18 Years and older (Adult, Senior) |
NCT02506530 |
14 7425 15 |
ELOCS |
September 2015 |
December 2016 |
December 2017 |
July 23, 2015 |
November 13, 2015 |
|
- MALLOIZEL DELAUNAY Julie
Toulouse, Midi Pyrenees, France
|
| 46 |
NCT02724514 |
Recruiting |
Multi-Parametric Assessment of Breast Lymphedema |
- Breast Cancer
- Breast Lymphedema
|
- Other: non-invasive image & bioimpedance based techniques
|
Observational |
|
- University Health Network, Toronto
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Measure Mid-Band Fit (MBF) in normal tissue controls and the corresponding regions of lymphedema
- Measure Acoustic Scatterer Diameter (ASD) in normal tissue controls and the corresponding regions of lymphedema
|
60 |
Female |
18 Years and older (Adult, Senior) |
NCT02724514 |
UHN REB 14-8503-C |
|
January 2015 |
November 2016 |
December 2018 |
March 31, 2016 |
September 25, 2017 |
|
- Princess Margaret Cancer Centre
Toronto, Ontario, Canada
|
| 47 |
NCT02158832 |
Withdrawn |
Acupuncture for Lymphedema Secondary to Breast Cancer Treatment |
|
- Device: Acupuncture + Electrical Stimulation
|
Interventional |
Not Applicable |
- McMaster University
- Canadian Interdisciplinary Network Complementary & Alternative Medicine Research
- Holistic Health Research Foundation of Canada
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in amount of arm tissue water determined by Bioimpedance Analysis
- Change in dermal concentration of red blood cells in the arm assessed using light polarization spectroscopy
- Change in arm circumference
- Lymphedema Questionnaire
|
0 |
Female |
18 Years and older (Adult, Senior) |
NCT02158832 |
HIREB 14-089 |
|
April 2014 |
January 2017 |
December 2017 |
June 9, 2014 |
August 30, 2017 |
|
- McMaster University
Hamilton, Ontario, Canada
|
| 48 |
NCT01115374 |
Completed |
Lymphedema Therapy With Sound Wave Lymphatic Drainage |
|
- Procedure: Manual lymphatic drainage
- Device: low frequency sound waves
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Volume of lymphedema
- Pain
- Quality of life
|
34 |
Female |
18 Years and older (Adult, Senior) |
NCT01115374 |
LES_OBSF_DLM |
|
May 2008 |
July 2009 |
July 2009 |
May 4, 2010 |
February 4, 2016 |
|
- Hospital de la Esperanza
Barcelona, Spain
|
| 49 |
NCT03252145 |
Recruiting |
Treatment of Breast Cancer-related Lymphedema With a Negative Pressure Device |
- Lymphedema, Secondary
- Lymphedema of Upper Limb
|
- Device: PhysioTouch
- Other: Manual Lymph Drainage (MLD)
|
Interventional |
Not Applicable |
- University of California, San Francisco
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Recruitment rates
- Retention rates
- Limb volume
- (and 15 more...)
|
80 |
Female |
18 Years and older (Adult, Senior) |
NCT03252145 |
P0518095 |
|
October 18, 2017 |
December 30, 2019 |
December 30, 2019 |
August 17, 2017 |
February 7, 2018 |
|
- University of California San Francisco
San Francisco, California, United States
|
| 50 |
NCT02257970 |
Completed |
Placebo-controlled Lymphedema Study for Arm or Leg Lymphedema |
|
- Drug: oral anti-inflammatory drug
- Drug: Placebo
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Amelioration of cutaneous histological architecture
- Bioimpedance readings
|
117 |
All |
18 Years to 90 Years (Adult, Senior) |
NCT02257970 |
7781 |
PB |
March 2009 |
December 2016 |
March 2017 |
October 7, 2014 |
March 2, 2018 |
|
- Stanford University
Stanford, California, United States
|
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