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74 studies found for:    kuvan
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Rank Status Study
21 Completed A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
22 Terminated
Has Results
Sapropterin on Cognitive Abilities in Young Adults With Phenylketonuria
Condition: Phenylketonuria
Interventions: Drug: Sapropterin;   Drug: Placebo
23 Completed
Has Results
Tetrahydrobiopterin Treatment in Children With Idiopathic Cognitive Developmental Disorders
Condition: Autism Spectrum Disorder
Intervention: Drug: sapropterin dihydrochloride
24 Withdrawn Neuroimaging and Neurocognitive Assessment and Response to Sapropterin Dihydrochloride Treatment in Phenylketonuria
Condition: PKU
Interventions: Dietary Supplement: diet;   Drug: sapropterin dihydrochloride
25 Withdrawn Trial of Kuvan in Lesch-Nyhan Disease
Condition: Behavioral Manifestations of Lesch-Nyhan Disease
Intervention: Drug: sapropterin
26 Completed
Has Results
Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) Patients
Condition: Phenylketonuria
Interventions: Drug: Sapropterin dihydrochloride;   Drug: Placebo
27 Completed
Has Results
Sapropterin as a Treatment for Autistic Disorder
Condition: Autistic Disorder
Interventions: Drug: sapropterin;   Drug: Placebo
28 Completed Effects of Tetrahydrobiopterin on Blood Pressure
Condition: Hypertension
Intervention: Drug: Tetrahydrobiopterin
29 Recruiting Observational Study on the Long Term Safety of Kuvan® Treatment in Patients With Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or BH4 Deficiency
Condition: Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or Tetrahydrobiopterin (BH4) Deficiency
30 Completed
Has Results
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
Condition: Phenylketonuria
Intervention: Drug: KuvanTM Therapy
31 Unknown  Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
Condition: Coronary Artery Disease
Intervention: Drug: 6R-BH4
32 Not yet recruiting The Effectiveness of Kuvan in Amish PKU Patients
Condition: Phenylketonuria
Interventions: Drug: saproterin dihydrochloride;   Other: Diet treatment
33 Completed
Has Results
Tetrahydrobiopterin in Patients With Chronic Kidney Disease (CKD) and Albuminuria
Conditions: Kidney Disease;   Albuminuria
Interventions: Drug: 6R BH4;   Dietary Supplement: Vitamin C
34 Completed A Study of the Effects of 6R-BH4 on Blood Pressure in Subjects With Poorly Controlled Systemic Hypertension
Condition: Hypertension
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
35 Recruiting Neurovascular Transduction During Exercise in Chronic Kidney Disease
Condition: Renal Insufficiency, Chronic
Interventions: Drug: 6R-BH4;   Other: Placebo;   Dietary Supplement: Folic acid;   Other: Exercise Training;   Other: Stretching
36 Completed Study of BH4, a New and Simple Treatment of Mild PKU
Condition: Phenylketonuria
Intervention: Drug: 5,6,7,8-tetrahydrobiopterin
37 Approved for marketing Sapropterin Expanded Access Program
Condition: Phenylketonuria
Intervention: Drug: Sapropterin dihydrochloride
38 Unknown  Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction
Conditions: Isolated Systolic Hypertension;   Endothelial Dysfunction
Interventions: Drug: 6R-BH4;   Other: Placebo
39 Terminated Long-Term Tetrahydrobiopterin Treatment in PKU Patients of 0-18 Years - Study on Phenylalanine Tolerance and Safety
Condition: Phenylalanine Hydroxylase Deficiencies
Intervention: Drug: tetrahydrobiopterin (BH4)
40 Recruiting Sex Hormones and Atherosclerosis Prevention in Perimenopausal Women
Conditions: Menopause;   Aging
Interventions: Drug: KUVAN;   Drug: Placebo;   Drug: Cetrotide;   Drug: Climara;   Drug: Placebo transdermal patch

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Indicates status has not been verified in more than two years