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76 studies found for:    kuvan
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Rank Status Study
21 Terminated
Has Results
Sapropterin on Cognitive Abilities in Young Adults With Phenylketonuria
Condition: Phenylketonuria
Interventions: Drug: Sapropterin;   Drug: Placebo
22 Completed A Phase 2 Study of the Effects of 6R-BH4 in Subjects With Sickle Cell Disease
Condition: Sickle Cell Disease
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
23 Completed A Phase 2, Pharmacokinetic Study of the Effects of 6R-BH4 Alone or 6R-BH4 With Vitamin C in Subjects With Endothelial Dysfunction
Condition: Endothelial Dysfunction
Intervention: Drug: 6R-BH4 (sapropterin dihydrochloride)
24 Completed Effects of Tetrahydrobiopterin on Blood Pressure
Condition: Hypertension
Intervention: Drug: Tetrahydrobiopterin
25 Unknown  Effect of 6R-BH4 Treatment in Coronary Artery Disease (OXBIO Study)
Condition: Coronary Artery Disease
Intervention: Drug: 6R-BH4
26 Recruiting Observational Study on the Long Term Safety of Kuvan® Treatment in Patients With Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or BH4 Deficiency
Condition: Hyperphenylalaninemia (HPA) Due to Phenylketonuria (PKU) or Tetrahydrobiopterin (BH4) Deficiency
27 Completed
Has Results
Tetrahydrobiopterin in Patients With Chronic Kidney Disease (CKD) and Albuminuria
Conditions: Kidney Disease;   Albuminuria
Interventions: Drug: 6R BH4;   Dietary Supplement: Vitamin C
28 Not yet recruiting The Effectiveness of Kuvan in Amish PKU Patients
Condition: Phenylketonuria
Interventions: Drug: saproterin dihydrochloride;   Other: Diet treatment
29 Completed
Has Results
Sapropterin as a Treatment for Autistic Disorder
Condition: Autistic Disorder
Interventions: Drug: sapropterin;   Drug: Placebo
30 Completed
Has Results
Nutritional and Neurotransmitter Changes in PKU Subjects on BH4
Condition: Phenylketonuria
Intervention: Drug: KuvanTM Therapy
31 Withdrawn Neuroimaging and Neurocognitive Assessment and Response to Sapropterin Dihydrochloride Treatment in Phenylketonuria
Condition: PKU
Interventions: Dietary Supplement: diet;   Drug: sapropterin dihydrochloride
32 Approved for marketing Sapropterin Expanded Access Program
Condition: Phenylketonuria
Intervention: Drug: Sapropterin dihydrochloride
33 Completed A Phase 2 Study of the Effects of 6R-BH4 on Symptomatic Peripheral Arterial Disease
Condition: Intermittent Claudication
Interventions: Drug: Placebo for 6R-BH4 (sapropterin dihydrochloride);   Drug: 6R-BH4 (sapropterin dihydrochloride)
34 Completed Study of BH4, a New and Simple Treatment of Mild PKU
Condition: Phenylketonuria
Intervention: Drug: 5,6,7,8-tetrahydrobiopterin
35 Unknown  Oral 6R-BH4 for the Treatment of Isolated Systolic Hypertension and Endothelial Dysfunction
Conditions: Isolated Systolic Hypertension;   Endothelial Dysfunction
Interventions: Drug: 6R-BH4;   Other: Placebo
36 Unknown  The Purpose of This Pilot Study is to Assess the Impact of KUVAN® (Sapropterin Dihydrochloride) on Gastric Relaxation in Women With Diabetic Gastroparesis.
Condition: Gastroparesis
Intervention: Drug: sapropterin dihydrochloride
37 Active, not recruiting Endothelial Facilitation in Alzheimer's Disease
Condition: Alzheimer's Disease
Intervention: Drug: Simvastatin + L-Arginine + Tetrahydrobiopterin
38 Completed
Has Results
Safety and Therapeutic Effects of Sapropterin Dihydrochloride on Neuropsychiatric Symptoms in Phenylketonuria (PKU) Patients
Condition: Phenylketonuria
Interventions: Drug: Sapropterin dihydrochloride;   Drug: Placebo
39 Recruiting Rhode Island Diastolic Dysfunction - Heart Failure
Conditions: Heart Failure;   Cardiovascular Disease
Intervention: Drug: Kuvan
40 Recruiting PKUDOS: Phenylketonuria (PKU) Demographic, Outcomes, and Safety Registry
Conditions: Phenylketonuria;   Hyperphenylalaninaemia
Intervention: Drug: Kuvan

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Study has passed its completion date and status has not been verified in more than two years.