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109 studies found for:    integrins
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Rank Status Study
1 Recruiting a4b7 Integrin in Eosinophilic Esophagitis
Condition: Eosinophilic Esophagitis
Intervention: Other: Eosinophil isolation and characterization.
2 Recruiting Integrin Alpha-v-Beta and [18F]-R01-MG-F2 PET/CT in Measuring Response in Patients With Pancreatic Cancer and Healthy Volunteers
Conditions: Healthy Subject;   Pancreatic Carcinoma
Interventions: Procedure: Computed Tomography;   Other: Laboratory Biomarker Analysis;   Procedure: Positron Emission Tomography;   Drug: [18F]FP-R01-MG-F2;   Drug: [18F]-FDG
3 Terminated
Has Results
A Safety Study Of A Monoclonal Antibody Against A5B1 Integrin In Solid Tumors
Condition: Advanced Non-Hematologic Malignancies
Intervention: Drug: PF-04605412
4 Completed The Role of Platelet Surface α2β1 Integrin Expression as a Risk Factor in Thrombotic and/or Bleeding Complications
Condition: Genetic Polymorphism
5 Completed Evaluating The Antitumor Activity Of MEDI-522 With Or Without Dacarbazine In Patients With Metastatic Melanoma
Conditions: Melanoma;   Malignant Metastatic Melanoma
Interventions: Biological: MEDI--522;   Biological: Integrin + Dacarbazine
6 Recruiting Eosinophil β1 Integrin Activation as a Biomarker for Eosinophilic Esophagitis
Condition: Eosinophilic Esophagitis
Intervention: Other: Observation Period
7 Completed
Has Results
A Proof-of-concept Study to Assess the Ability of [18F]AH-111585 PET Imaging to Detect Tumours and Angiogenesis
Conditions: High-grade Glioma;   Lung Cancer;   Head & Neck Cancer;   Sarcoma;   Melanoma
Intervention: Drug: Fluciclatide Injection - (AH111585 (F18))
8 Recruiting Dual Integrin αvβ3 and SSTR2 Targeting PET Imaging in Lung Cancer Patients
Condition: Lung Cancer
Intervention: Drug: 68Ga-NOTA-3PTATE-RGD
9 Recruiting Dual Integrin αvβ3 and GRPR Targeting PET Imaging in Breast Cancer Patients
Condition: Breast Cancer
Intervention: Drug: 68Ga-NOTA-BBN-RGD
10 Terminated Study of M200 (Volociximab) in Patients With Metastatic Renal Cell Carcinoma (RCC)
Conditions: Renal Cell Carcinoma;   Metastases
Intervention: Drug: Volociximab (anti-α5β1 integrin monoclonal antibody)
11 Recruiting Eosinophil Induced Remodelling in Asthma
Conditions: Allergic Asthma;   Airway Remodelling
Interventions: Procedure: Bronchial challenge with allergen;   Other: Co-culture formation
12 Recruiting A Pilot Study to Assess the Efficacy of Rituximab Therapy in Treatment Resistant FSGS
Condition: Primary Focal Segmental Glomerulosclerosis
Intervention: Biological: Rituximab
13 Unknown  RGD-PET-CT in Cancer Angiogenesis
Condition: Carcinoma, Renal Cell
Intervention: Drug: 18F-RGD-PET-CT and perfusion CT scans on 3 occasions
14 Withdrawn Monoclonal Antibody Therapy in Treating Patients With Advanced Solid Tumors
Condition: Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: monoclonal antibody anti-anb3 integrin;   Procedure: anti-cytokine therapy;   Procedure: antiangiogenesis therapy;   Procedure: antibody therapy;   Procedure: biological response modifier therapy;   Procedure: growth factor antagonist therapy;   Procedure: monoclonal antibody therapy
15 Terminated Study to Develop a Non-invasive Marker for Monitoring Myocardial Fibrosis
Conditions: Hypertrophic Cardiomyopathy;   Acute Coronary Syndrome
Intervention: Radiation: 99mTc-NC100692
16 Completed A Pharmacokinetic (PK) Study of Natalizumab (Tysabri) at Steady State
Condition: Multiple Sclerosis
Intervention: Drug: Natalizumab
17 Completed Inhaled Corticosteroid Replacement Study - Efficacy and Safety of Ro 27-2441 (Test Drug) in Moderate Persistent Asthma
Condition: Asthma
Intervention: Drug: Dual Integrin Antagonist
18 Completed Evaluation of Various Doses of Ro 27-2771 (Test Drug) in Asthmatic Patients Not Treated With Inhaled Corticosteroids
Condition: Asthma
Intervention: Drug: Dual Integrin Antagonist
19 Not yet recruiting Hormone Therapy With or Without Definitive Radiotherapy in Metastatic Prostate Cancer
Condition: Prostate Cancer
Interventions: Radiation: Radiotherapy to the pelvis;   Drug: Hormonal therapy (LHRH agonist and/or antiandrogens)
20 Completed A Phase 1 Ascending and Parallel Group Trial to Establish the Safety, Tolerability and Pharmacokinetics Profile of Volociximab (Alpha 5 Beta 1 Integrin Antagonist) in Subjects With Neovascular Age- Related Macular Degeneration
Condition: Age-related Macular Degeneration
Intervention: Drug: volociximab

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Study has passed its completion date and status has not been verified in more than two years.