1 |
NCT03719794 |
Recruiting |
Probiotics for Vascular Inflammation in Metabolic Syndrome |
|
- Dietary Supplement: Probiotic supplement
- Dietary Supplement: Placebo supplement
|
Interventional
|
Not Applicable |
- Montreal Heart Institute
- Lallemand Health Solutions
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- The primary outcome is to evaluate the change on vascular inflammation (measured by FDG-PET), so as to test the hypothesis that probiotic treatment reduces vascular inflammation in comparison to placebo.
- Mesure of High-sensitivity C-reactive protein (hs-CRP) a systemic inflammatory marker.
- Mesure of Tumor necrosis factor alpha (TNF-α) a systemic inflammatory marker.
- (and 3 more...)
|
24 |
All |
50 Years and older (Adult, Older Adult) |
NCT03719794 |
2016-2038 |
PROMISE |
April 16, 2018 |
April 2019 |
September 2019 |
October 25, 2018 |
October 25, 2018 |
|
- Cardiovascular Prevention and Rehabilitation Center
Montreal, Quebec, Canada
|
|
2 |
NCT03514667 |
Recruiting |
The Effects of Nanocurcumin on Serum Oxidative Stress,Inflammation,Adiponectin and NF-kB in Blood Mononuclear Cells in Metabolic Syndrome Patients (Nuclear Factor-κB) |
|
- Dietary Supplement: nanomicielle curcumin
- Dietary Supplement: placebo
|
Interventional
|
Not Applicable |
- National Nutrition and Food Technology Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Supportive Care
|
- Serum Total antioxidant capacity (TAC)
- Serum Malondialdehyde (MDA)
- Serum C-reactive protein (CRP)
- (and 3 more...)
|
50 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03514667 |
188 |
|
August 30, 2018 |
August 30, 2019 |
January 30, 2020 |
May 2, 2018 |
July 31, 2018 |
|
- Golbon Sohrab
Tehran, National Nutrition And Food Technology Research Institute, Iran, Islamic Republic of
|
|
3 |
NCT03836651 |
Recruiting New |
Dietary Intervention in Persons With Metabolic Syndrome |
|
- Other: Dietary Antioxidant (V8® Low Sodium 100% vegetable juice)
- Other: Control group
|
Interventional
|
Not Applicable |
- Martha Biddle
- University of Kentucky
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in plasma C-reactive Protein (CRP) from baseline to one month.
- Change in plasma Malondialdehyde (MDA) from baseline to one month.
|
100 |
All |
21 Years to 90 Years (Adult, Older Adult) |
NCT03836651 |
45582 |
MetLDI |
December 1, 2018 |
November 30, 2019 |
December 31, 2019 |
February 11, 2019 |
February 11, 2019 |
|
- University of Kentucky
Lexington, Kentucky, United States
|
|
4 |
NCT02732509 |
Recruiting |
Chronic Inflammation and Exercise Responsiveness |
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Maximal oxygen consumption rates in mitochondria isolated from skeletal muscles
|
45 |
All |
30 Years to 55 Years (Adult) |
NCT02732509 |
16-000437 |
|
March 2016 |
December 2019 |
December 2019 |
April 8, 2016 |
November 6, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
|
5 |
NCT03241394 |
Recruiting |
The Monocyte Subsets in Obese Patients With and Without Metabolic Syndrome |
- Obesity
- Metabolic Syndrome
|
|
Observational
|
|
- University Hospital, Ioannina
|
Other |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
|
100 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03241394 |
802 |
|
July 25, 2017 |
September 15, 2017 |
September 15, 2017 |
August 7, 2017 |
August 7, 2017 |
|
- University Hospital of Ioannina
Ioánnina, Greece
|
|
6 |
NCT03059355 |
Recruiting |
Infusion of Umbilical Cord Versus Bone Marrow Derived Mesenchymal Stem Cells to Evaluate Cytokine Suppression. |
- Endothelial Dysfunction
- Metabolic Syndrome
- Chronic Inflammation
|
- Biological: UCMSCs
- Biological: BMMSCs
- Other: Placebo
|
Interventional
|
Phase 1 Phase 2 |
- Joshua M Hare
- University of Miami
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of any treatment-emergent serious adverse events (TE-SAEs)
- Change of inflammatory markers
- Effect on Frailty Phenotype Score
- (and 4 more...)
|
37 |
All |
21 Years to 95 Years (Adult, Older Adult) |
NCT03059355 |
20170095 |
CERES |
April 12, 2018 |
June 2025 |
June 2026 |
February 23, 2017 |
September 26, 2018 |
|
- ISCI / University of Miami Miller School of Medicine
Miami, Florida, United States
|
|
7 |
NCT03418857 |
Recruiting |
Probiotics and Gut Health |
|
- Drug: Yogurt smoothie with BB-12
- Drug: Yogurt smoothie
|
Interventional
|
Phase 1 Phase 2 |
- Penn State University
- United States Department of Agriculture (USDA)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Change from baseline in inflammatory markers
- Change in number and activation of leukocytes
- Change in gut permeability
- (and 2 more...)
|
40 |
All |
55 Years to 75 Years (Adult, Older Adult) |
NCT03418857 |
STUDY0006843 |
PRO |
June 29, 2018 |
June 2019 |
December 2019 |
February 1, 2018 |
November 7, 2018 |
|
- The Pennsylvania State University
University Park, Pennsylvania, United States
|
|
8 |
NCT02124512 |
Recruiting |
Blood Lipopolysaccharide (LPS) Rifaximin Study |
- Obese
- Insulin Resistance
- Metabolic Syndrome
|
- Drug: Rifaximin SSD
- Other: Placebo
|
Interventional
|
Phase 2 |
- Philip Kern
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Decrease in circulating LPS
- Decrease in tissue inflammation
|
40 |
All |
35 Years to 65 Years (Adult, Older Adult) |
NCT02124512 |
14-0136-F1V UL1TR000117 1R21DK100258-01A1 |
|
March 2015 |
May 31, 2018 |
June 2018 |
April 28, 2014 |
January 19, 2018 |
|
- University of Kentucky Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
|
9 |
NCT03441620 |
Recruiting |
The Effects of Strawberries on Blood Cholesterol. |
- Hyper-LDL-cholesterolemia
- Metabolic Syndrome
|
- Dietary Supplement: strawberries
- Other: Control powder
|
Interventional
|
Not Applicable |
- University of Nevada, Las Vegas
- University of Oklahoma
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Serum Lipid profiles
- Systemic Inflammation
- Systemic Anthocyanins
|
40 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03441620 |
1119274 |
|
February 1, 2018 |
February 28, 2019 |
December 31, 2019 |
February 21, 2018 |
February 22, 2018 |
|
- University of Nevada at Las Vegas
Las Vegas, Nevada, United States - University of Oklahoma Health Sciences Center, OCTSI
Oklahoma City, Oklahoma, United States
|
|
10 |
NCT03440736 |
Recruiting |
Comparison of Secukinumab 300 mg Combined With a Lifestyle Intervention to Secukinumab Alone for the Treatment of Moderate to Severe Psoriasis Patients With Concomitant Metabolic Syndrome |
- Psoriasis
- Metabolic Syndrome
|
- Drug: Secukinumab
- Behavioral: Life-style intervention
|
Interventional
|
Phase 4 |
- Novartis Pharmaceuticals
- Novartis
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- PASI 90
- PASI 75
- hsCRP
- (and 24 more...)
|
760 |
All |
18 Years and older (Adult, Older Adult) |
NCT03440736 |
CAIN457ADE08 |
METABOLYX |
February 28, 2018 |
September 15, 2020 |
March 30, 2021 |
February 21, 2018 |
October 9, 2018 |
|
- Novartis Investigative Site
Magdeburg, Sachen Anhalt, Germany - Novartis Investigative Site
Andernach, Germany - Novartis Investigative Site
Augsburg, Germany - (and 71 more...)
|
|
11 |
NCT03754504 |
Recruiting |
Effects of Cranberry Powder Supplements on Gut Microbiota Diversity and Metabolic Syndrome |
- Overweight
- Insulin Resistance
- Microbiota
- (and 2 more...)
|
- Dietary Supplement: Cranberry powder
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Gut Microbiota Diversity
- Change in Endotoxemia
- Change in Intestinal permeability
- (and 6 more...)
|
25 |
Male |
18 Years to 60 Years (Adult) |
NCT03754504 |
MICA 2018-146 |
MICA |
October 15, 2018 |
December 31, 2019 |
June 30, 2020 |
November 27, 2018 |
November 27, 2018 |
|
- Institut sur la nutrition et les aliments fonctionnels
Québec, Canada
|
|
12 |
NCT03727321 |
Recruiting |
FMT and Fiber in Patients With Metabolic Syndrome |
- Obesity
- Metabolic Syndrome
|
- Combination Product: Fecal Microbial Transplant
- Dietary Supplement: Fiber
- Dietary Supplement: Cellulose
|
Interventional
|
Phase 2 |
- University of Alberta
- The Weston A. Price Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Insulin Sensitivity Assessment
- Health-related quality of life (HRQL): EQ-5D Index
- Dietary Intake
- (and 7 more...)
|
68 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03727321 |
Pro00076642 |
FMT |
July 1, 2018 |
March 1, 2020 |
March 1, 2021 |
November 1, 2018 |
November 1, 2018 |
|
- Royal Alexandra Hospital
Edmonton, Alberta, Canada - University of Alberta Hospital
Edmonton, Alberta, Canada
|
|
13 |
NCT03806920 |
Recruiting |
Isomaltulose VS Sucrose - Postprandial Effect on Incretin Profile and Second Meal Effect |
- Diabetes Mellitus, Type 2
- Metabolic Syndrome
|
- Dietary Supplement: Intervention A
- Dietary Supplement: Intervention B
- Dietary Supplement: Intervention C
- Dietary Supplement: Intervention D
|
Interventional
|
Not Applicable |
- German Institute of Human Nutrition
- Beneo GmbH
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- disposition index
- insulinogenic index
- hepatic insulin extraction
- (and 4 more...)
|
30 |
All |
45 Years to 75 Years (Adult, Older Adult) |
NCT03806920 |
PALA |
|
November 5, 2016 |
January 31, 2019 |
March 31, 2019 |
January 16, 2019 |
January 16, 2019 |
|
- German Institute of Human Nutrition
Potsdam, Brandenburg, Germany
|
|
14 |
NCT03477916 |
Recruiting |
Fecal Microbial Transplantation and Fiber Supplementation in Participants With Obesity and Metabolic Syndrome. |
- Obesity
- Metabolic Syndrome
|
- Biological: FMT
- Biological: Placebo FMT
- Dietary Supplement: Prebiotic Fiber
- Dietary Supplement: Cellulose
|
Interventional
|
Phase 2 |
- University of Alberta
- The Weston A. Price Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- insulin sensitivity
- BMI
- Waist to hip circumferences
- (and 10 more...)
|
68 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03477916 |
00076642 |
|
April 9, 2018 |
April 1, 2020 |
April 1, 2020 |
March 27, 2018 |
May 10, 2018 |
|
- Royal Alexandra Hospital
Edmonton, Alberta, Canada
|
|
15 |
NCT03589690 |
Not yet recruiting |
Alpha Lipoic Acid Supplementation and Metabolic Syndrome |
|
- Dietary Supplement: Alpha lipoic acid
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
- Dr. B.Abbasi
- Science & Research Islamic Azad University Branch Khozestan
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change from Baseline of CRP
- Change from baseline of Tnf-a
- Change from baseline of FBS
- (and 3 more...)
|
44 |
All |
18 Years to 60 Years (Adult) |
NCT03589690 |
IR.IAU.SRB.REC.1396.82 |
|
July 25, 2018 |
April 25, 2019 |
July 25, 2019 |
July 18, 2018 |
July 18, 2018 |
|
|
|
16 |
NCT03542240 |
Recruiting |
Effects of Curcumin Supplementation on Gut Barrier Function in Patients With Metabolic Syndrome |
- Obesity
- High Blood Pressure
- High Cholesterol
- (and 2 more...)
|
- Dietary Supplement: Curcumin
|
Interventional
|
Not Applicable |
- Virginia Commonwealth University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change inintestinal permeability
- Change in intestinal barrier function
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT03542240 |
HM20012060 |
|
September 19, 2018 |
December 1, 2019 |
December 1, 2019 |
May 31, 2018 |
February 19, 2019 |
|
- Virginia Commonwealth University
Richmond, Virginia, United States
|
|
17 |
NCT02991209 |
Recruiting |
Study of Testosterone vs Placebo in Testicular Cancer Survivors |
- Metabolic Syndrome
- Testicular Cancer
- Leydig Cell Failure in Adult
|
- Drug: Testosterone
- Drug: Placebos
|
Interventional
|
Phase 2 Phase 3 |
- Mikkel Bandak
- Rigshospitalet, Denmark
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in insulin sensitivity
- Changes in fasting plasma lipids between baseline and 52 weeks
- Changes in BMD and fat percent between baseline 52 weeks
- (and 11 more...)
|
70 |
Male |
18 Years to 65 Years (Adult, Older Adult) |
NCT02991209 |
010815Testis |
Einstein |
November 2016 |
August 2019 |
December 2019 |
December 13, 2016 |
January 11, 2017 |
|
- Rigshospitalet
Copenhagen, Denmark
|
|
18 |
NCT03604250 |
Recruiting |
The January Application NUtritional Study (JANUS) |
|
- Dietary Supplement: Lifestyle plus prebiotic supplement
|
Interventional
|
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
|
14 |
All |
30 Years to 60 Years (Adult) |
NCT03604250 |
2018-44 |
JANUS |
February 2019 |
May 2019 |
May 2019 |
July 27, 2018 |
December 3, 2018 |
|
- January, Inc.
Menlo Park, California, United States
|
|
19 |
NCT02954588 |
Recruiting |
Effect of Pyridoxamine Supplementation on Vascular Function and Insulin Sensitivity |
- Abdominal Obesity Metabolic Syndrome
|
- Dietary Supplement: Pyridoxamine
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
- Maastricht University Medical Center
- Top Institute Food and Nutrition
- Center for Translational Molecular Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Insulin sensitivity
- Microvascular function
|
120 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02954588 |
NL51023.068.16 |
|
October 14, 2016 |
February 2019 |
February 2019 |
November 3, 2016 |
May 1, 2018 |
|
- Maastricht University Medical Center
Maastricht, Netherlands
|
|
20 |
NCT03306056 |
Recruiting |
Whole-body Electromyostimulation Versus Conventional Low-volume Strength Training in Overweight Individuals |
- Overweight and Obesity
- Metabolic Syndrome
|
- Other: Control
- Other: Standard Strength Training
- Other: Low-volume Strength Training
- Other: Whole-Body Electromyostimulation (WB-EMS)
|
Interventional
|
Not Applicable |
- University of Erlangen-Nürnberg Medical School
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Metabolic Syndrome Z-Score (MetS-Z-Score)
- Muscle strength
- Body Composition
- (and 6 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03306056 |
EKAM-Study |
EKAM |
November 1, 2017 |
September 30, 2020 |
September 30, 2020 |
October 10, 2017 |
October 17, 2018 |
|
- Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports,
Erlangen, Germany
|
|
21 |
NCT03777722 |
Recruiting |
Light and the Effect on Metabolic Syndrome and Alzheimer's Disease |
- Alzheimer Disease
- Diabetes Mellitus, Type 2
|
- Device: Tailored Lighting Intervention
|
Interventional
|
Not Applicable |
- Rensselaer Polytechnic Institute
- Icahn School of Medicine at Mount Sinai
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Glucose tolerance
- change in depression
- Change in sleep disturbance
|
60 |
All |
55 Years and older (Adult, Older Adult) |
NCT03777722 |
1R01AG060716-01-NOA 1R01AG060716-01 |
|
November 1, 2018 |
December 31, 2022 |
October 31, 2023 |
December 17, 2018 |
December 19, 2018 |
|
- Rensselaer Polytechnic Institute
Troy, New York, United States
|
|
22 |
NCT03489109 |
Recruiting |
2-5 Intermittent Caloric Restriction for Weight Loss and Insulin Resistance in HIV-Infected Adults With Features of the Metabolic Syndrome |
- Human Immunodeficiency Virus
- Metabolic Syndrome
|
- Behavioral: Intermittent fasting
- Behavioral: Standard of Care
|
Interventional
|
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in weight and insulin sensitivity as measured by HOMA-IR
- Tolerability of ICR
- Change in lipid levels, metabolic biomarkers, biomarkers of inflammation and immune activation, and mood.
- Change in body composition, including visceral adiposity abd hepatic steatosis.
|
100 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03489109 |
180075 18-I-0075 |
|
May 9, 2018 |
January 31, 2022 |
January 31, 2022 |
April 5, 2018 |
January 15, 2019 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
23 |
NCT03710447 |
Recruiting |
Effects of Concurrent HIIT and WB-EMS Exercise on the Cardiometabolic Risk Profile in Obese Individuals |
- Overweight and Obesity
- Metabolic Syndrome
|
- Other: HIIT + WB-EMS
- Other: WB-EMS + HIIT
- Other: HIIT + CST
- Other: CST + HIIT
|
Interventional
|
Not Applicable |
- University of Erlangen-Nürnberg Medical School
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Metabolic Syndrome Z-Score (MetS-Z-Score).
- Change in overall Physical Fitness Score (PFS)
- Change in Body Composition
- (and 6 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03710447 |
COMBI-Study |
|
October 15, 2018 |
October 30, 2021 |
October 30, 2021 |
October 18, 2018 |
October 18, 2018 |
|
- Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports, Friedrich-Alexander-University Erlangen-Nuremberg
Erlangen, Germany
|
|
24 |
NCT03113994 |
Recruiting |
Statin Monotherapy for Treatment of Endocrine Metabolic Disease Risk |
- Spinal Cord Injuries
- Osteoporosis
- Metabolic Syndrome
|
- Drug: Rosuvastatin Calcium
- Drug: Placebo Oral Tablet
- Dietary Supplement: Coenzyme Q10
- (and 2 more...)
|
Interventional
|
Phase 2 |
- Dr. B. Catharine. Craven
- The Craig H. Neilsen Foundation
- Toronto Rehabilitation Institute
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline in areal BMD of the knee region
- Change from Baseline in Low density lipoprotein cholesterol (LDL)
- Change from Baseline in high density lipoprotein cholesterol (HDL)
- (and 13 more...)
|
54 |
All |
18 Years to 60 Years (Adult) |
NCT03113994 |
2016-350642 |
RoBaCO |
February 26, 2018 |
December 2020 |
December 2020 |
April 14, 2017 |
November 1, 2018 |
|
- University Of Miami Miller School of Medicine
Miami, Florida, United States - University Health Network - Toronto Rehab Lyndhurst Centre
Toronto, Ontario, Canada
|
|
25 |
NCT03306069 |
Recruiting |
Effects of Low-volume Aerobic Interval Training in Overweight Individuals at Increased Cardiometabolic Risk |
- Overweight and Obesity
- Metabolic Syndrome
|
- Other: Control
- Other: HIIT
- Other: MIIT-HR
- Other: MIIT-LT
|
Interventional
|
Not Applicable |
- University of Erlangen-Nürnberg Medical School
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cardiorespiratory Fitness (CRF)
- Metabolic Syndrome Z-Score (MetS-Z-Score)
- Body Composition
- (and 6 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03306069 |
BELITA-Study |
BELITA |
November 1, 2017 |
September 30, 2020 |
September 30, 2020 |
October 10, 2017 |
October 16, 2018 |
|
- Department of Medicine 1, Hector Center for Nutrition, Exercise and Sports,
Erlangen, Germany
|
|
26 |
NCT02252081 |
Recruiting |
Metformin in Kidney Disease |
- Chronic Kidney Disease
- Cardiovascular Disease
- Metabolic Syndrome
|
- Drug: metformin
- Drug: Placebo
|
Interventional
|
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- leptin to adiponectin ratio (LAR)
- estimated glomerular filtration rate (eGFR)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT02252081 |
ENDA-014-13F 1I01CX000982-01A1 |
|
October 1, 2014 |
December 31, 2019 |
December 31, 2019 |
September 29, 2014 |
February 18, 2019 |
|
- Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States
|
|
27 |
NCT02743598 |
Recruiting |
Liraglutide for HIV-associated Neurocognitive Disorder |
- HIV Infection
- Diabetes Mellitus Type 2
- Obesity
- (and 2 more...)
|
|
Interventional
|
Phase 4 |
- Temple University
- The Comprehensive NeuroAIDS Center (CNAC) at Temple University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Neurocognitive performance- change in global cognitive scores on a standard neuropsychological profile
- Neurocognitive performance- change in domain averages on a standard neuropsychological profile
- Change from baseline high sensitivity C-reactive protein
- (and 15 more...)
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02743598 |
23284 |
|
September 2016 |
April 2019 |
May 2019 |
April 19, 2016 |
September 18, 2018 |
|
- Cherie Vaz
Philadelphia, Pennsylvania, United States
|
|
28 |
NCT02642172 |
Recruiting |
Prebiotics in Patients With Non-alcoholic Liver Disease |
- Non-alcoholic Fatty Liver Disease
- Metabolic Syndrome
|
- Dietary Supplement: ITF (Inulin/OFS 75/25)
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in the severity of NAFLD
- Change from baseline of gut microbiota composition.
- Change from baseline in glycemic control
- (and 2 more...)
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02642172 |
PN-837-CTIL |
|
January 2016 |
January 2020 |
January 2020 |
December 30, 2015 |
August 28, 2018 |
|
- Kaplan Medical Center
Rechovot, Israel
|
|
29 |
NCT03805802 |
Recruiting |
Influence of a Liquid Oat Bran Product on Blood Glucose in Patients With Poorly Controlled Type 2 Diabetes |
- Diabetes Mellitus, Type 2
- Obesity
- Overweight
- Metabolic Syndrome
|
- Other: active product
- Other: reference product
|
Interventional
|
Not Applicable |
- Stoffwechselzentrum Rhein - Pfalz
- Glucanova AB
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Fasting glucose
- HBA1c
- Self-documented glucose
- (and 11 more...)
|
30 |
All |
30 Years to 70 Years (Adult, Older Adult) |
NCT03805802 |
012019 |
|
January 2019 |
December 2019 |
March 2020 |
January 16, 2019 |
January 29, 2019 |
|
- Stoffwechselzentrum Rhein-Pfalz
Mannheim, Baden-Württemberg, Germany
|
|
30 |
NCT03620617 |
Recruiting |
Effect of Raspberry on Gut Microbiota and Metabolic Syndrome |
- Gut Microbiota
- Metabolic Syndrome
|
- Dietary Supplement: Raspberry supplement
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Changes in plasma insulin/glucose of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group).
- Changes in plasma lipides/lipoproteins of overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group).
- Changes in gene expression in overweight/obese men and women taking frozen raspberries daily or following their usual diet (control group).
- (and 5 more...)
|
56 |
All |
18 Years to 55 Years (Adult) |
NCT03620617 |
RAMI 2017-218 |
|
January 8, 2018 |
October 2019 |
September 2020 |
August 8, 2018 |
December 7, 2018 |
|
- Laval University
Québec, Canada
|
|
31 |
NCT02695433 |
Recruiting |
Replacing Refined Carbohydrates With Healthy Fats on Cardio-metabolic Markers |
- Pre-diabetes
- Metabolic Syndrome
|
- Dietary Supplement: Active
- Dietary Supplement: Control
|
Interventional
|
Not Applicable |
- Institute for Food Safety and Health, United States
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Changes in insulin sensitivity as measured by the Matsuda composite index of insulin sensitivity (MISI) in 12-week intervention of active treatment vs control treatment.
- Changes in fasting blood glucose response in 12-week intervention of active treatment vs control treatment.
- Changes in fasting blood insulin response in 12-week intervention of active treatment vs control treatment.
- (and 10 more...)
|
120 |
All |
25 Years to 60 Years (Adult) |
NCT02695433 |
IRB2016-001 |
AV2 |
March 1, 2016 |
October 15, 2019 |
October 15, 2019 |
March 1, 2016 |
July 23, 2018 |
|
- Clinical Nutrition Research Center
Chicago, Illinois, United States
|
|
32 |
NCT03825276 |
Recruiting New |
Effect of Mango on Gut Microbiota and Metabolic Health |
- Gut Microbiota
- Metabolic Syndrome
|
- Dietary Supplement: Mango consumption
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Changes in plasma insulin concentration of overweight/obese men and women taking frozen mangos daily
- Changes in plasma glucose concentration of overweight/obese men and women taking frozen mangos daily
- Changes in plasma triglycerides concentration of overweight/obese men and women taking frozen mangos daily
- (and 22 more...)
|
30 |
All |
18 Years to 55 Years (Adult) |
NCT03825276 |
MANGO 2018-147 |
|
January 15, 2019 |
September 2019 |
December 2021 |
January 31, 2019 |
February 15, 2019 |
|
- Laval University
Québec, Canada
|
|
33 |
NCT03800277 |
Recruiting |
Effect of Cranberry and Agaves Extract on Microbiota and Intestinal Health |
- Endotoxemia
- Metabolic Syndrome
- Glucose Metabolism Disorders
- Insulin Resistance
|
- Dietary Supplement: Cranberry
- Dietary Supplement: Agaves
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
- Laval University
- Ministry of Agriculture, Fisheries and Food, Quebec
- Ministry of economic development, innovation and export trade, Quebec
- (and 5 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in metabolic endotoxemia: Measure concentration of Lipopolysaccharides (LPS) and Lipopolysaccharide Binding Protein (LBP) in plasma
- Change in intestinal permeability: Measure concentration of zonulin in plasma
- Change in inflammation state of the tissue: Measure concentration of calprotectin and lactoferrin in feces
- (and 4 more...)
|
80 |
All |
40 Years to 65 Years (Adult, Older Adult) |
NCT03800277 |
GASTRO-Phenulin (2016-317) |
Phenulin |
November 5, 2018 |
December 31, 2019 |
June 30, 2020 |
January 11, 2019 |
January 11, 2019 |
|
- Institute of nutrition and functional foods, Laval University
Québec, Quebec, Canada
|
|
34 |
NCT02858102 |
Recruiting |
Impact of Aerobic Exercise on Metabolic Syndrome, Neurocognition and Empowerment in Individuals With Mental Disorders |
- Metabolic Syndrome
- Mental Disorders
|
- Behavioral: Physical activity program
|
Interventional
|
Not Applicable |
- Fundación Marques de Valdecilla
- Centro de Investigación Biomédica en Red de Salud Mental
- Instituto de Investigación Marqués de Valdecilla
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in abdominal obesity measured by waist circumference
- Change in dyslipidemia measured by serum triglycerides and/or high-density lipoprotein (HDL cholesterol) levels.
- Change in hypertension measured by blood pressure
- (and 2 more...)
|
50 |
All |
35 Years to 50 Years (Adult) |
NCT02858102 |
EXERTMG |
EXERTMG |
June 2016 |
December 2019 |
December 2019 |
August 8, 2016 |
February 15, 2019 |
|
- University Hospital Marqués de Valdecilla
Santander, Cantabria, Spain
|
|
35 |
NCT02936687 |
Recruiting |
Mechanisms of Cerebrovascular Control |
|
- Drug: NOS Inhibition
- Drug: ET-1 Inhibition
- Drug: NOS Inhibition Placebo
- (and 4 more...)
|
Interventional
|
Phase 1 |
- University of Wisconsin, Madison
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in cerebrovascular blood flow in response to NOS inhibition.
- Change in cerebrovascular blood flow in response to ET-1 inhibition.
|
60 |
All |
18 Years to 45 Years (Adult) |
NCT02936687 |
2015-0197 |
|
January 31, 2017 |
December 2019 |
December 2019 |
October 18, 2016 |
November 2, 2018 |
|
- University of Wisconsin, Madison
Madison, Wisconsin, United States
|
|
36 |
NCT03381469 |
Recruiting |
Periodontitis and Adverse Pregnancy Outcomes in Metabolic Syndrome Patients- Interventional Study |
- Low Birth Weight Baby
- Metabolic Syndrome
- Pregnancy Complications
- (and 3 more...)
|
- Procedure: Comprehensive periodontal treatment
- Procedure: single visit supragingival scaling
|
Interventional
|
Not Applicable |
- Riyadh Colleges of Dentistry and Pharmacy
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Periodontal parameters- Change in Gingival Index
- Periodontal parameters- Change in Plaque Index
- Periodontal parameters-Change in Bleeding on probing
- (and 6 more...)
|
150 |
Female |
18 Years to 34 Years (Adult) |
NCT03381469 |
MetS in Pregnancy |
|
February 10, 2018 |
August 1, 2018 |
December 1, 2018 |
December 22, 2017 |
February 13, 2018 |
|
- Riyadh Colleges of Dentistry and Pharmacy
Riyadh, Saudi Arabia - Riyadh Colleges of Dentistry and Pharmacy
Riyadh, Saudi Arabia
|
|
37 |
NCT02470260 |
Recruiting |
Northern Manhattan Study of Metabolism and Mind |
- Diabetes
- Pre-diabetes
- Cognition - Other
- (and 2 more...)
|
|
Observational
|
|
- Columbia University
- National Institute on Minority Health and Health Disparities (NIMHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Cognition
- Transitions in diabetes status
- Metabolic syndrome
- Depressive symptoms
|
1000 |
All |
50 Years to 64 Years (Adult) |
NCT02470260 |
AAAI5156 P60MD000206 |
NOMEM |
January 2012 |
December 2020 |
December 2020 |
June 12, 2015 |
September 15, 2015 |
|
- Columbia University Medical Center
New York, New York, United States
|
|
38 |
NCT02460445 |
Recruiting |
Phlebotomy and Polycystic Ovary Syndrome |
- Hyperandrogenism
- Metabolic Cardiovascular Syndrome
|
- Procedure: Phlebotomy
- Drug: ethinylestradiol
- Drug: Cyproterone Acetate
|
Interventional
|
Not Applicable |
- Manuel Luque Ramírez
- Instituto de Salud Carlos III
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in the Matsuda index from the circulating glucose and insulin concentrations during and standard oral glucose tolerance test.
- Percentage of patients with Hb < 12 g/dl or hematocrit <36% throughout the study
- Change in the percentage of patients with undiagnosed prediabetes/diabetes between month 0 and 12 of follow-up
- (and 5 more...)
|
30 |
Female |
18 Years to 45 Years (Adult) |
NCT02460445 |
PI14/00649 |
|
January 2015 |
June 2019 |
June 2019 |
June 2, 2015 |
February 7, 2019 |
|
- Diabetes, Obesity and Human Reproduction Research Group, Department of Endocrinology and Nutrition, Hospital Universitario Ramón y Cajal, Universidad de Alcalá, Instituto Ramón y Cajal de Investigación Sanitaria (IRYCIS)
Madrid, Spain
|
|
39 |
NCT03807752 |
Not yet recruiting |
Marin Protein Hydrolysate and Metabolic Syndrome |
|
- Dietary Supplement: MPH_active
- Dietary Supplement: MPH_placebo
|
Interventional
|
Not Applicable |
- Helse Møre og Romsdal HF
- Haukeland University Hospital
- University of Bergen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Glucose
- Insulin
- Hormon hunger 1
- (and 5 more...)
|
60 |
All |
40 Years to 70 Years (Adult, Older Adult) |
NCT03807752 |
2018/2163 |
MPH_MetS |
February 2019 |
June 2019 |
June 2019 |
January 17, 2019 |
January 17, 2019 |
|
- Haukeland University Hospital
Bergen, Norway - Ålesund Hospital, Helse Møre og Romsdal HF
Ålesund, Norway
|
|
40 |
NCT02515357 |
Recruiting |
Mediterranean Lifestyle Intervention in Patients With Obstructive Sleep Apnea |
|
- Behavioral: Mediterranean lifestyle
- Behavioral: Standard care
- Behavioral: Mediterranean diet
|
Interventional
|
Not Applicable |
- Harokopio University
- National and Kapodistrian University of Athens
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Severity of obstructive sleep apnea
- Sleep quality
- Daytime sleepiness
- (and 4 more...)
|
150 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02515357 |
46 |
|
June 2015 |
December 2019 |
December 2019 |
August 4, 2015 |
December 20, 2018 |
|
- Harokopio University
Kallithea, Attiki, Greece
|
|
41 |
NCT03624569 |
Recruiting |
Cardiometabolic Benefits of Potatoes Mediated Along the Gut-Vessel Axis in Adults With Metabolic Syndrome |
- Cardiovascular Diseases
- Endotoxemia
- Endothelial Dysfunction
- (and 2 more...)
|
- Other: Bagel
- Other: Potato
|
Interventional
|
Not Applicable |
- Ohio State University
- Alliance for Potato Research and Education
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Endotoxin
- Vascular endothelial function
- Clinical chemistries
- (and 21 more...)
|
30 |
All |
18 Years to 50 Years (Adult) |
NCT03624569 |
2018H0265 |
|
August 15, 2018 |
September 2019 |
September 2020 |
August 10, 2018 |
August 22, 2018 |
|
- Ohio State University
Columbus, Ohio, United States
|
|
42 |
NCT01679431 |
Recruiting |
Metabolic Determinants of the Progression of Aortic Stenosis |
|
- Diagnostic Test: Doppler-echocardiography
- Radiation: Computed tomography
- Other: Magnetic resonance imaging
- Biological: Fasting blood sample
|
Observational
|
|
- Laval University
- Canadian Institutes of Health Research (CIHR)
- Heart and Stroke Foundation of Canada
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Progression of aortic valve stenosis
- Progression of aortic valve calcification
- Progression of myocardial fibrosis and dysfunction
|
250 |
All |
21 Years and older (Adult, Older Adult) |
NCT01679431 |
MOP-114997 |
PROGRESSA |
April 2005 |
January 2022 |
January 2022 |
September 6, 2012 |
August 23, 2018 |
|
- Institut Universitaire de Cardiologie et de Pneumologie de Québec
Québec, Canada
|
|
43 |
NCT03528031 |
Recruiting |
Habitual Diet and Avocado Trial |
- Intra-abdominal Fat
- Metabolic Syndrome
- High Cholesterol
- (and 11 more...)
|
- Other: Intervention Daily Avocado
|
Interventional
|
Not Applicable |
- Wake Forest University Health Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Visceral adiposity
- Hepatic lipid content
- Metabolic syndrome markers (serum triglycerides, serum cholesterol, fasting serum glucose, fasting insulin)
- (and 10 more...)
|
1000 |
All |
25 Years and older (Adult, Older Adult) |
NCT03528031 |
IRB00047011 |
HAT |
June 19, 2018 |
June 2021 |
January 2022 |
May 17, 2018 |
August 31, 2018 |
|
- Loma Linda University
Loma Linda, California, United States - University of California Los Angles (UCLA)
Los Angeles, California, United States - Tufts University
Medford, Massachusetts, United States - Pennysylvania State University
University Park, Pennsylvania, United States
|
|