1 |
NCT01809288 |
Recruiting |
Identifying Risk for Diabetes and Heart Disease in Women |
- Obesity
- Insulin Resistance
- Triglycerides
- Diabetes
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Determine if there are differences in African, African-American and white women in the relationship between triglyceride levels, (a frequently used screening test for diabetes and heart disease) glucose tolerance status and insulin resistance.
|
360 |
Female |
25 Years to 65 Years (Adult) |
NCT01809288 |
130090 13-DK-0090 |
|
March 9, 2013 |
April 30, 2022 |
April 30, 2022 |
March 12, 2013 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
2 |
NCT03064295 |
Recruiting |
Whole-Heart Myocardial Blood Flow Quantification Using MRI |
- Coronary Artery Disease
- Coronary Microvascular Disease
|
- Device: Myocardial Perfusion Cardiac MRI.
- Drug: Contrast
- Drug: Pharmacologic Stress Agent
|
Observational |
|
- Cedars-Sinai Medical Center
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- CAD findings by MRI
- CMD findings by MRI
|
160 |
All |
18 Years and older (Adult, Senior) |
NCT03064295 |
42972 1R01HL124649 |
|
March 1, 2018 |
January 1, 2025 |
January 1, 2025 |
February 27, 2017 |
March 13, 2018 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
3 |
NCT02045459 |
Recruiting |
Microvascular Disease Exercise Trial |
- Coronary Microvascular Disease
|
- Behavioral: Exercise Program
- Drug: Medical Therapy
|
Interventional |
Phase 1 Phase 2 |
- University of Virginia
- Astellas Pharma Global Development, Inc.
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Change in MPR on CMR imaging from baseline with intensive medical therapy + supervised exercise versus intensive medical therapy alone.
- Incremental change in MPR with exercise over intensive medical therapy alone in the exercise subgroup
- Identification of reduced MPR (<2.0 ml/g/min) and borderline reduced MPR
|
165 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02045459 |
16821 1K23HL119620-01 |
MOVE |
May 2014 |
July 2018 |
July 2018 |
January 24, 2014 |
May 25, 2016 |
|
- University of Virginia
Charlottesville, Virginia, United States - University of Virginia
Charlottesville, Virginia, United States
|
4 |
NCT00001853 |
Recruiting |
Diabetes and Heart Disease Risk in Blacks |
- Cardiovascular
- Diabetes
- Obesity
- Hypertension
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Diabetes and Heart Disease Risk
|
1132 |
All |
18 Years to 65 Years (Adult) |
NCT00001853 |
990002 99-DK-0002 |
|
October 9, 1998 |
|
|
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
5 |
NCT02204709 |
Recruiting |
Disease Risk Reduction and Omega-3 Rich Rainbow Trout (Fish for Health) |
|
- Other: 2N Trout
- Other: 3N Trout
- Other: Tilapia
|
Interventional |
Not Applicable |
- USDA Grand Forks Human Nutrition Research Center
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Change from baseline in platelet activation at week 6 of each treatment
- Change from baseline in plasma interleukin-6 (IL-6) at week 6 of each treatment
- Change from baseline in plasma tumor necrosis factor alpha (TNFa) at week 6 of each treatment
- (and 6 more...)
|
43 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT02204709 |
GFHNRC029 |
|
June 2015 |
September 2018 |
December 2019 |
July 30, 2014 |
March 19, 2018 |
|
- USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States
|
6 |
NCT02153983 |
Recruiting |
Effects of Colchicine in Non-Diabetic Adults With Metabolic Syndrome |
|
- Drug: Colchicine 0.6 mg given
- Drug: Placebo capsules given
|
Interventional |
Phase 1 Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in insulin sensitivity
- Change in metabolic parameters
- Changes in other inflammatory markers
|
250 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT02153983 |
140119 14-CH-0119 |
|
May 31, 2014 |
June 29, 2018 |
December 31, 2018 |
June 3, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
7 |
NCT02640690 |
Recruiting |
Trauma-Sensitive Yoga for Female Veterans With PTSD Who Experienced Military Sexual Trauma |
- Stress Disorders, Post-traumatic
|
- Behavioral: Trauma Sensitive Yoga Intervention
- Behavioral: Cognitive Processing Therapy-Cognitive Only
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Determine the effectiveness of TSY compared to CPT-C in reducing PTSD symptoms, chronic pain, and insomnia
- To evaluate the effectiveness of TSY as compared to CPT-C in improving quality of life and social functioning in women Veterans with PTSD related to MST.
- To evaluate the effectiveness of TSY as compared to CPT-C on biological stress response and psychophysiological hyper-responsivity.
- (and 10 more...)
|
210 |
Female |
18 Years and older (Adult, Senior) |
NCT02640690 |
NRI 15-151 |
PSL II |
January 1, 2016 |
July 1, 2019 |
December 31, 2019 |
December 29, 2015 |
February 12, 2018 |
|
- Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States
|
8 |
NCT03170375 |
Not yet recruiting |
Dietary Prevention of Heart Failure in Hypertensive Metabolic Syndrome |
|
- Behavioral: Performance of WHEELS-I in promoting DASH/SRD adoption
- Behavioral: Effects of a 2-week DASH/SRD intervention vs. control diet on HFpEF functional cardiovascular risk factors
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Carotid-femoral pulse wave velocity
- Left ventricular mass index
- Ventricular stiffness
- (and 3 more...)
|
130 |
All |
45 Years and older (Adult, Senior) |
NCT03170375 |
CARA-009-16F 9050 |
|
June 4, 2018 |
December 30, 2022 |
December 30, 2022 |
May 31, 2017 |
February 26, 2018 |
|
- VA Ann Arbor Healthcare System, Ann Arbor, MI
Ann Arbor, Michigan, United States
|
9 |
NCT03418857 |
Not yet recruiting |
Probiotics and Gut Health |
|
- Drug: Yogurt smoothie with BB-12
- Drug: Yogurt smoothie
|
Interventional |
Phase 1 Phase 2 |
- Penn State University
- United States Department of Agriculture (USDA)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Change from baseline in inflammatory markers
- Change in number and activation of leukocytes
- Change in gut permeability
- (and 2 more...)
|
40 |
All |
55 Years to 75 Years (Adult, Senior) |
NCT03418857 |
STUDY0006843 |
PRO |
May 2018 |
December 2018 |
December 2019 |
February 1, 2018 |
April 19, 2018 |
|
- The Pennsylvania State University
University Park, Pennsylvania, United States
|
10 |
NCT02919176 |
Recruiting |
Brown Fat Activation Study |
|
- Drug: Mirabegron
- Drug: Pioglitazone
- Drug: Mirabegron and Pioglitazone
|
Interventional |
Early Phase 1 |
- Philip Kern
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in beige adipose tissue
- Change in brown adipose tissue
- Change in insulin sensitivity
- (and 2 more...)
|
75 |
All |
35 Years to 65 Years (Adult) |
NCT02919176 |
16-0642-F1V |
|
September 1, 2016 |
December 1, 2019 |
December 1, 2020 |
September 29, 2016 |
May 25, 2017 |
|
- Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
11 |
NCT02633891 |
Recruiting |
Metabolic Syndrome and Fall Risk |
- Metabolic Syndrome
- Autonomic Neuropathy
|
- Behavioral: Balance exercise
- Behavioral: Standard care
|
Interventional |
Not Applicable |
- VA Office of Research and Development
- University of Maryland
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Four Square Step Test (FSST)
- Dynamic Gait Index (DGI)
|
55 |
All |
50 Years to 70 Years (Adult, Senior) |
NCT02633891 |
F1651-W 1IK2RX001651-01A2 |
|
January 2, 2017 |
July 1, 2020 |
December 31, 2020 |
December 17, 2015 |
February 5, 2018 |
|
- Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States
|
12 |
NCT03355469 |
Recruiting |
Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome |
|
- Combination Product: LoEx+Metformin
- Combination Product: HiEx+Metformin
- Combination Product: LoEx+Placebo
- Combination Product: HiEx+Placebo
|
Interventional |
Phase 4 |
- University of Virginia
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in Flow Mediated Dilation of brachial artery
- Change in Metabolic Insulin Sensitivity by the Euglycemic Clamp
- Change in Post Ischemic Flow Velocity in brachial artery
- (and 4 more...)
|
80 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT03355469 |
19364 1R01HL130296-01A1 |
|
August 7, 2017 |
June 30, 2021 |
January 31, 2022 |
November 28, 2017 |
November 28, 2017 |
|
- University of Virginia
Charlottesville, Virginia, United States
|
13 |
NCT02124512 |
Recruiting |
Blood Lipopolysaccharide (LPS) Rifaximin Study |
- Obese
- Insulin Resistance
- Metabolic Syndrome
|
- Drug: Rifaximin SSD
- Other: Placebo
|
Interventional |
Phase 2 |
- Philip Kern
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Kentucky
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Decrease in circulating LPS
- Decrease in tissue inflammation
|
40 |
All |
35 Years to 65 Years (Adult) |
NCT02124512 |
14-0136-F1V UL1TR000117 1R21DK100258-01A1 |
|
March 2015 |
May 31, 2018 |
June 2018 |
April 28, 2014 |
January 19, 2018 |
|
- University of Kentucky Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
14 |
NCT03022669 |
Recruiting |
Mobile Health Strategies for Veterans |
|
- Behavioral: Text Message
- Behavioral: Mobile Application
- Other: Website
|
Interventional |
Phase 2 |
- University of California, San Francisco
- San Francisco Veterans Affairs Medical Center
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
225 |
All |
21 Years and older (Adult, Senior) |
NCT03022669 |
1IK3HX002055-01A1 |
|
December 2016 |
November 2020 |
November 2020 |
January 16, 2017 |
January 16, 2017 |
|
- John Muir Medical Center
Concord, California, United States - San Francisco Veterans Affairs Medical Center
San Francisco, California, United States
|
15 |
NCT03288207 |
Not yet recruiting |
Tailoring Mobile Health Technology to Reduce Obesity and Improve Cardiovascular Health in Resource-Limited Neighborhood Environments |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Steps per day as measured by the PA (physical activity) device
|
180 |
Female |
18 Years to 75 Years (Adult, Senior) |
NCT03288207 |
170162 17-H-0162 |
|
April 27, 2018 |
December 31, 2020 |
December 31, 2020 |
September 20, 2017 |
April 24, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
16 |
NCT02596776 |
Recruiting |
Cold Induced Changes in White Adipose |
- Obese
- Normal Body Weight
- Prediabetes
- Metabolic Syndrome
|
- Procedure: Fat biopsy
- Drug: Propranolol and fat biopsy
- Other: heavy water and fat biopsy
|
Interventional |
Early Phase 1 |
- Philip Kern
- National Institutes of Health (NIH)
- University of Kentucky
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- WAT changes during repeated exposure to cold temperatures
- WAT changes following Propranolol dosing
- In vivo measurement of adipose lipolysis and triglyceride (TG) turnover
|
90 |
Female |
35 Years to 60 Years (Adult) |
NCT02596776 |
15-0663 |
|
March 2016 |
December 2019 |
December 2019 |
November 4, 2015 |
May 8, 2017 |
|
- University of Kentucky Medical Center Center for Clinical and Translational Science
Lexington, Kentucky, United States
|
17 |
NCT02252081 |
Recruiting |
Metformin in Kidney Disease |
- Chronic Kidney Disease
- Cardiovascular Disease
- Metabolic Syndrome
|
- Drug: metformin
- Drug: Placebo
|
Interventional |
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- leptin to adiponectin ratio (LAR)
- estimated glomerular filtration rate (eGFR)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02252081 |
ENDA-014-13F 1I01CX000982-01A1 |
|
October 1, 2014 |
December 31, 2019 |
December 31, 2019 |
September 29, 2014 |
January 19, 2018 |
|
- Tennessee Valley Healthcare System Nashville Campus, Nashville, TN
Nashville, Tennessee, United States
|
18 |
NCT02740699 |
Recruiting |
CT COMPARE: CT COronary Angiography to Measure PlAque REduction |
|
- Drug: Rosuvastatin
- Drug: Atorvastatin
|
Interventional |
Phase 4 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To prospectively compare the change in coronary artery plaque burden determined by CCTA in asymptomatic individuals with moderate CVD risk treated either a) according to 2013 ACC/AHA Guideline on the Treatment of Blood Cholesterol to Reduce Athe...
|
190 |
All |
45 Years to 75 Years (Adult, Senior) |
NCT02740699 |
160089 16-H-0089 |
|
April 14, 2016 |
December 15, 2020 |
December 15, 2020 |
April 15, 2016 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
19 |
NCT01994811 |
Recruiting |
Eastern Caribbean Health Outcomes Research Network (ECHORN) |
- Cancer
- Cardiovascular Disease
- Diabetes
|
|
Observational |
|
- Yale University
- National Institute on Minority Health and Health Disparities (NIMHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Diabetes
- Cardiovascular disease
|
4400 |
All |
18 Years and older (Adult, Senior) |
NCT01994811 |
1108008959 5U24MD006938 |
ECHORN |
April 2013 |
December 2018 |
December 2018 |
November 26, 2013 |
January 16, 2018 |
|
- University of the West Indies, Cave Hill Campus
Bridgetown, Barbados - University of Puerto Rico Medical Sciences Campus
San Juan, Puerto Rico - University of the West Indies, St. Augustine Campus
St. Augustine, West Indies, Trinidad and Tobago - University of the Virgin Islands
Saint Thomas, Virgin Islands (U.S.)
|
20 |
NCT03495986 |
Not yet recruiting New |
Spinal Cord Injury Exercise and Nutrition Conceptual Engagement |
- Spinal Cord Injuries
- Metabolic Syndrome
- Dietary Modification
- (and 2 more...)
|
- Device: Functional Electrical Stimulation Leg Cycle Ergometry
- Behavioral: Diet
|
Interventional |
Not Applicable |
- Milton S. Hershey Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Percent Body fat
- Fat Mass and Fat-Free Mass
- Insulin Sensitivity (Si)
- (and 5 more...)
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT03495986 |
6996 R01HD091278-01 |
SCIENCE |
April 2018 |
April 2022 |
July 2022 |
April 12, 2018 |
April 12, 2018 |
|
- Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
21 |
NCT02470260 |
Recruiting |
Northern Manhattan Study of Metabolism and Mind |
- Diabetes
- Pre-diabetes
- Cognition - Other
- (and 2 more...)
|
|
Observational |
|
- Columbia University
- National Institute on Minority Health and Health Disparities (NIMHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Cognition
- Transitions in diabetes status
- Metabolic syndrome
- Depressive symptoms
|
1000 |
All |
50 Years to 64 Years (Adult) |
NCT02470260 |
AAAI5156 P60MD000206 |
NOMEM |
January 2012 |
December 2020 |
December 2020 |
June 12, 2015 |
September 15, 2015 |
|
- Columbia University Medical Center
New York, New York, United States
|
22 |
NCT02268513 |
Recruiting |
Mediators of Atherosclerosis in South Asians Living in America (MASALA) Social Network Study |
|
|
Observational |
|
- Northwestern University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of MASALA participants with high kin density
|
900 |
All |
40 Years and older (Adult, Senior) |
NCT02268513 |
STU00083722 R01HL120725 |
|
September 2014 |
December 2017 |
February 2018 |
October 20, 2014 |
January 16, 2017 |
|
- University of California at San Francisco
San Francisco, California, United States - Northwestern University
Chicago, Illinois, United States
|
23 |
NCT02874053 |
Not yet recruiting |
The Role of Emotions and Regulatory Focus in Decision Making That Involves Risk Tradeoffs |
|
|
Observational |
|
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Cross-Sectional
|
- willingness to take hypothetical pill
|
600 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02874053 |
999916161 16-C-N161 |
|
August 17, 2016 |
August 2, 2018 |
August 2, 2018 |
August 22, 2016 |
December 8, 2017 |
|
- University of Pittsburgh
Pittsburgh, Maryland, United States
|
24 |
NCT03417388 |
Recruiting |
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD |
|
- Drug: High dose potent statin
- Drug: Evolocumab
- Drug: ACE-I (lisinopril) or ARB (losartan)
- (and 3 more...)
|
Interventional |
Phase 4 |
- University of Florida
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- All Cause Death incidents reported between the two groups
- Non-fatal myocardial infarction (MI) incidents reported between the two groups
- Stroke/TIA incidents reported between the two groups
- (and 2 more...)
|
4422 |
Female |
18 Years to 100 Years (Adult, Senior) |
NCT03417388 |
IRB201701142 -A PR161603 |
WARRIOR |
February 9, 2018 |
December 30, 2021 |
December 30, 2022 |
January 31, 2018 |
February 14, 2018 |
|
- Family Medicine at Eastside Community Practice
Gainesville, Florida, United States - Family Medicine at Hampton Oaks Medical Plaza (Adults and Peds)
Gainesville, Florida, United States - Internal Medicine at Tower Hill
Gainesville, Florida, United States - (and 8 more...)
|
25 |
NCT03489109 |
Recruiting New |
2-5 Intermittent Caloric Restriction for Weight Loss and Insulin Resistance in HIV-Infected Adults With Features of the Metabolic Syndrome |
- Human Immunodeficiency Virus
- Metabolic Syndrome
|
- Behavioral: Intermittent fasting
- Behavioral: Standard of Care
|
Interventional |
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in weight and insulin sensitivity as measured by HOMA-IR
- Tolerability of ICR
- Change in lipid levels, metabolic biomarkers, biomarkers of inflammation and immune activation, and mood.
- Change in body composition, including visceral adiposity abd hepatic steatosis.
|
100 |
All |
18 Years to 65 Years (Adult) |
NCT03489109 |
180075 18-I-0075 |
|
April 27, 2018 |
January 31, 2022 |
January 31, 2022 |
April 5, 2018 |
April 24, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
26 |
NCT01196182 |
Recruiting |
Congenital Heart Disease GEnetic NEtwork Study (CHD GENES) |
|
|
Observational |
|
- Children's Hospital Medical Center, Cincinnati
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
10000 |
All |
up to 99 Years (Child, Adult, Senior) |
NCT01196182 |
701 5U01HL098188-03 U01HL098188 U01HL098147 U01HL098163 U01HL098153 U01HL098123 U01HL098162 |
CHD GENES |
November 2010 |
July 2020 |
July 2020 |
September 8, 2010 |
April 5, 2017 |
|
- Children's Hospital Los Angeles
Los Angeles, California, United States - Stanford University
Palo Alto, California, United States - University of California, San Francisco
San Francisco, California, United States - (and 10 more...)
|
27 |
NCT02641145 |
Recruiting |
Molecular Imaging of Primary Amyloid Cardiomyopathy |
- Amyloidosis, Primary
- Cardiomyopathy
|
- Radiation: F-18 florbetapir/C-11 acetate PET
- Device: MRI
- Radiation: N-13 ammonia PET
|
Interventional |
Not Applicable |
- Brigham and Women's Hospital
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
- (and 2 more...)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Change in F-18 florbetapir myocardial retention index from baseline to 6 months and 12 months
- Change in Serum oxidative stress markers from baseline to 6 months and 12 months
- Change in Myocardial oxidative metabolism markers from baseline to 6 months
- (and 3 more...)
|
125 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02641145 |
2015P002477 1R01HL130563-01A1 |
MICA |
April 2016 |
April 2020 |
April 2020 |
December 29, 2015 |
December 4, 2017 |
|
- Brigham and Womens' Hospital
Boston, Massachusetts, United States
|
28 |
NCT03423238 |
Recruiting |
Targeting Obesity to Optimize Health in Cardiac Rehab (TOPCARE) |
- Obesity
- Weight Loss
- CHD - Coronary Heart Disease
|
- Other: Exercise
- Other: Meeting with Dietitian
- Behavioral: Health Education
- (and 4 more...)
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Study Feasibilty
- Compliance
- Change in Body weight
- (and 9 more...)
|
40 |
All |
50 Years to 80 Years (Adult, Senior) |
NCT03423238 |
IRB00046110 1R56HL134989-01A1 |
TOPCARE |
March 21, 2018 |
August 31, 2019 |
August 31, 2019 |
February 6, 2018 |
March 22, 2018 |
|
- Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States
|
29 |
NCT01258231 |
Recruiting |
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery |
- Heart; Dysfunction Postoperative, Cardiac Surgery
- Genetic Predisposition to Disease
- Atrial Fibrillation
- (and 2 more...)
|
|
Observational |
|
- Brigham and Women's Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
- Texas Heart Institute
- (and 2 more...)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Atrial fibrillation
- Death
- Renal dysfunction
|
4000 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT01258231 |
2000P001639 5R01HL098601 |
CABGGenomics |
August 2000 |
August 2020 |
August 2020 |
December 10, 2010 |
October 4, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - UT Southwestern Medical Center
Dallas, Texas, United States - Department Texas Heart Institute at St. Luke's Episcopal Hospital
Houston, Texas, United States
|
30 |
NCT02805309 |
Recruiting |
Home-Based Exercise Program For Recovery After Transcatheter Aortic Valve Replacement |
|
- Behavioral: Exercise
- Behavioral: Cognitive behavioral interventions
- Behavioral: Attention control education program
|
Interventional |
Not Applicable |
- Brigham and Women's Hospital
- Hebrew SeniorLife
- National Institute on Aging (NIA)
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Change in the Late-Life Function and Disability Instrument (LLFDI) Score
- Change in the Short Physical Performance Battery (SPPB) Summary Score
- Change in the 2-Minute walk distance (meters)
- (and 2 more...)
|
60 |
All |
65 Years and older (Adult, Senior) |
NCT02805309 |
2017P000106 P30AG031679 P30AG048785 |
REHAB-TAVR |
August 1, 2017 |
August 31, 2018 |
October 31, 2018 |
June 20, 2016 |
December 20, 2017 |
|
- Hebrew SeniorLife
Boston, Massachusetts, United States - Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
31 |
NCT03186794 |
Recruiting |
Aerobic Exercise in Women With Systemic Lupus Erythematosus |
- Systemic Lupus Erythematosus
- Lupus
- Autoimmune Disease
- Rheumatic Disease
|
- Other: Treadmill exercise training
|
Interventional |
Phase 1 |
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- The primary outcome measure for our trial will be the time taken to attain the anaerobic threshold, which is a performance marker of fatigability that is unaffected by patient motivation or perception.
- Exercise training induced changes in muscle oxygenation and cardiac function and changes in questionnaire responses.
|
30 |
Female |
21 Years to 80 Years (Adult, Senior) |
NCT03186794 |
170111 17-CC-0111 |
|
February 22, 2018 |
December 31, 2022 |
December 31, 2022 |
June 14, 2017 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
32 |
NCT02812238 |
Recruiting |
Study to Evaluate the Effect of Nicotinamide Riboside on Immunity |
- Atherosclerosis
- Diabetes
- Coronary Artery Disease
|
- Dietary Supplement: Nicotinamide riboside (NR)
- Other: Placebo
|
Interventional |
Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- The refeeding IL-1 secretion in response to inflammasome stimulation in the NR treatment arm versus the same subject's response on the placebo treatment arm using paired t-test analyses
|
42 |
All |
18 Years to 39 Years (Adult) |
NCT02812238 |
160129 16-H-0129 |
|
June 23, 2016 |
May 31, 2018 |
March 5, 2019 |
June 24, 2016 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
33 |
NCT02816736 |
Recruiting |
EntrestoTM (LCZ696) In Advanced Heart Failure (LIFE Study) |
|
- Drug: LCZ696
- Drug: valsartan
- Drug: LCZ696 placebo
- Drug: valsartan placebo
|
Interventional |
Phase 4 |
- Duke University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in NT-proBNP
- Composite endpoint of the effects of LCZ696 (number of days)
- Tolerability - target dose
- (and 6 more...)
|
400 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02816736 |
Pro00071722 5U01HL084904 |
HFN-LIFE |
March 2, 2017 |
September 30, 2019 |
March 30, 2020 |
June 29, 2016 |
April 24, 2018 |
|
- Cedars-Sinai Heart Institute
Beverly Hills, California, United States - Sutter Health Mills-Peninsula Health Services
Sacramento, California, United States - San Diego Cardiac Center
San Diego, California, United States - (and 36 more...)
|
34 |
NCT03345446 |
Recruiting |
Circulating RNAs in Acute Congestive Heart Failure |
- Acute Congestive Heart Failure
- Heart Failure With Reduced Ejection Fraction
- Heart Failure With Normal Ejection Fraction
|
- Diagnostic Test: Cardiac MRI
|
Observational |
|
- Massachusetts General Hospital
- Beth Israel Deaconess Medical Center
- Brigham and Women's Hospital
- (and 2 more...)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Plasma RNAs levels (rpm by RNAseq) in patients with acute CHF
- Correlation of plasma RNA levels (rpm by RNAseq) with CMR measurements of ventricular function and in vitro fibroblast proliferation assay.
|
200 |
All |
18 Years and older (Adult, Senior) |
NCT03345446 |
2016P001250 16SFRN29490000 1K23HL127099-01A1 |
CRUCiAL |
August 17, 2016 |
June 2018 |
June 2020 |
November 17, 2017 |
November 17, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Brigham and Women's Hospital
Boston, Massachusetts, United States - Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States
|
35 |
NCT03192215 |
Recruiting |
AtRial Cardiopathy and Antithrombotic Drugs In Prevention After Cryptogenic Stroke |
|
- Drug: Apixaban
- Drug: Aspirin
|
Interventional |
Phase 3 |
- Columbia University
- National Institute of Neurological Disorders and Stroke (NINDS)
- University of Cincinnati
- (and 6 more...)
|
Other / NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of recurrent stroke
- Incidence of recurrent ischemic stroke or systemic embolism
- Incidence of recurrent stroke of any type plus death from any cause
- (and 3 more...)
|
1100 |
All |
45 Years and older (Adult, Senior) |
NCT03192215 |
AAAR4607 1U01NS095869-01A1 |
ARCADIA |
January 19, 2018 |
January 18, 2022 |
April 30, 2022 |
June 20, 2017 |
February 20, 2018 |
|
- University of Alabama
Birmingham, Alabama, United States - Huntsville Hospital
Huntsville, Alabama, United States - Banner University Medical Center - Tucson
Tucson, Arizona, United States - (and 118 more...)
|
36 |
NCT02152696 |
Recruiting |
Optimal Treatment for Women With a Persisting Pregnancy of Unknown Location |
- Persistent Pregnancy of Unknown Location
- Ectopic Pregnancy
|
- Drug: Methotrexate
- Procedure: Uterine Evacuation
- Other: Expectant Management
|
Interventional |
Phase 3 |
- Yale University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Augusta University
- (and 5 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Uneventful clinical resolution of a Pregnancy of Unknown Location without change from the initial management strategy
|
276 |
Female |
18 Years and older (Adult, Senior) |
NCT02152696 |
ACTorNOT |
ACTorNOT |
May 2014 |
May 2019 |
May 2021 |
June 2, 2014 |
April 18, 2018 |
|
- University of California San Francisco
San Francisco, California, United States - University of South Florida
Tampa, Florida, United States - Augusta University
Augusta, Georgia, United States - (and 12 more...)
|
37 |
NCT00012545 |
Recruiting |
Collection and Storage of Umbilical Cord Stem Cells for Treatment of Sickle Cell Disease |
- Sickle Cell Disease
- Sickle Cell Trait
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To procure umbilical cord blood (UCB) from newborns at risk for sickle cell disease, sickle cell trait, and related disorders as well as normal newborns, as controls
|
99999999 |
Female |
18 Years to 45 Years (Adult) |
NCT00012545 |
010122 01-H-0122 |
|
March 8, 2001 |
|
|
March 12, 2001 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
38 |
NCT02787044 |
Recruiting |
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure |
- Heart Failure
- Myocardial Infarction
|
- Biological: High Dose Trivalent Influenza Vaccine
- Biological: Standard Dose Quadrivalent Influenza Vaccine
|
Interventional |
Phase 4 |
- Brigham and Women's Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Wisconsin, Madison
- (and 4 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- All-Cause Death or Cardiopulmonary Hospitalization
- Total cardiopulmonary hospitalizations or death
- Death or cardiopulmonary hospitalization within each influenza season
- (and 4 more...)
|
9300 |
All |
18 Years and older (Adult, Senior) |
NCT02787044 |
2015P001823 U01HL130163 |
INVESTED |
August 2016 |
August 2020 |
February 2021 |
June 1, 2016 |
September 12, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - Boston/West Roxbury VA Hospital
West Roxbury, Massachusetts, United States - University of Wisconsin
Madison, Wisconsin, United States - University of Toronto
Toronto, Ontario, Canada
|
39 |
NCT01661010 |
Recruiting |
The Clinical Study of Sex Chromosome Variants |
- Klinefelter Syndrome
- Male Factor Infertility
- Female Factor Infertility
- (and 5 more...)
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT01661010 |
120181 12-HG-0181 |
|
July 31, 2012 |
|
|
August 9, 2012 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
40 |
NCT03141983 |
Recruiting |
Anti-Cytokine Therapy for Hemodialysis InflammatION |
|
- Drug: Anakinra
- Drug: Placebo
|
Interventional |
Phase 2 |
- University of Pennsylvania
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To evaluate the safety and tolerability of anakinra, for patients receiving maintenance hemodialysis
- Change in log-transformed circulating CRP concentration after 24 weeks of treatment for patients receiving maintenance hemodialysis
- Change in markers of inflammation and oxidative stress
- (and 8 more...)
|
80 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT03141983 |
826900 U01DK099919 |
ACTION |
December 15, 2017 |
April 2020 |
May 2021 |
May 5, 2017 |
January 8, 2018 |
|
- The George Washington University
Washington, District of Columbia, United States - Brigham & Women's Hospital
Boston, Massachusetts, United States - Vanderbilt University Medical Center
Nashville, Tennessee, United States - University of Washington Kidney Research Institute
Seattle, Washington, United States
|
41 |
NCT00985049 |
Recruiting |
TRANSCRIBE (Transcriptomic Analysis of Left Ventricular Gene Expression) |
|
|
Observational |
|
- Brigham and Women's Hospital
- American Heart Association
- Harvard Medical School
- (and 2 more...)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Differential gene expression
|
200 |
All |
20 Years and older (Adult, Senior) |
NCT00985049 |
2007p002323 R01HL118266 |
|
March 2009 |
June 2020 |
December 2020 |
September 28, 2009 |
July 19, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States
|
42 |
NCT00608725 |
Recruiting |
Pathophysiology of Orthostatic Intolerance |
- Tachycardia
- Postural Orthostatic Tachycardia Syndrome
|
- Radiation: DAXOR
- Procedure: QSweat
- Drug: Intrinsic Heart Rate
|
Interventional |
Not Applicable |
- Satish R. Raj
- National Institutes of Health (NIH)
- Vanderbilt University Medical Center
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Physiological abnormalities in orthostatic intolerance
- blood volume
- intrinsic heart rate
- (and 3 more...)
|
100 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00608725 |
8398 NIH HL56693 |
|
December 1996 |
December 2019 |
December 2019 |
February 6, 2008 |
March 27, 2018 |
|
- Vanderbilt University
Nashville, Tennessee, United States
|
43 |
NCT02055209 |
Recruiting |
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) |
- Hypertension
- Cardiovascular Disease
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- To develop a novel genomic science resource for defining the functional significance and human biology consequences of ancestry-related genomic variation in AA.
|
2019 |
All |
21 Years to 65 Years (Adult) |
NCT02055209 |
140048 14-HG-0048 |
|
February 4, 2014 |
June 4, 2018 |
June 4, 2018 |
February 5, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
44 |
NCT03261570 |
Recruiting |
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS |
- Postural Orthostatic Tachycardia Syndrome (POTS)
- POTS
- Orthostatic Intolerance
|
- Drug: Pyridostigmine
- Drug: Digoxin
- Drug: Placebo
|
Interventional |
Early Phase 1 |
- New York Medical College
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Cardiovagal Baroreflex during orthostatic stress
- Cognitive ability during orthostatic stress
- Cardiac output measure by inert gas breathing technique
- (and 3 more...)
|
80 |
Female |
15 Years to 30 Years (Child, Adult) |
NCT03261570 |
1R01HL134674-01A1 |
|
July 1, 2017 |
June 30, 2021 |
September 1, 2021 |
August 25, 2017 |
January 17, 2018 |
|
- New York Medical College/Bradhurst building
Hawthorne, New York, United States
|
45 |
NCT00001465 |
Recruiting |
Study of the Disease Process of Lymphangioleiomyomatosis |
- Lung Disease
- Pneumothorax
- Tuberous Sclerosis
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
99999999 |
All |
16 Years to 80 Years (Child, Adult, Senior) |
NCT00001465 |
950186 95-H-0186 |
|
September 25, 1995 |
|
|
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
46 |
NCT02439658 |
Recruiting |
Genetics of QT Prolongation With Antiarrhythmics |
- Long QT Syndrome
- Drug Toxicity
|
- Drug: Dofetilide and/or sotalol
|
Observational |
|
- Massachusetts General Hospital
- VA Office of Research and Development
- Beth Israel Deaconess Medical Center
- Brigham and Women's Hospital
|
Other / U.S. Fed |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- QT interval
- Successful drug initiation
|
500 |
All |
18 Years and older (Adult, Senior) |
NCT02439658 |
2013P001851 |
DOFEGEN |
January 2014 |
January 2019 |
January 2019 |
May 12, 2015 |
March 29, 2016 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States - Brigham and Womens Hospital
Boston, Massachusetts, United States - West Roxbury VA Medical Center
West Roxbury, Massachusetts, United States
|
47 |
NCT03221114 |
Not yet recruiting |
Positive Psychology Intervention for Spanish-speaking Hispanic/Latino Adults at Risk for Cardiovascular Disease |
- Uncontrolled Hypertension
- Cardiovascular Risk Factor
|
- Behavioral: Positive Psychological Intervention
|
Interventional |
Not Applicable |
- University of Illinois at Urbana-Champaign
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Ambulatory Blood Pressure at 8- and 12-weeks
- Center for Epidemiological Studies Depression Scale (CESD): Change from Baseline Depressive Symptoms at 8- and 12-weeks
- Life Orientation Test-Revised (LOT-R): Change from Baseline Dispositional Optimism at 8- and 12-weeks
- (and 2 more...)
|
126 |
All |
18 Years and older (Adult, Senior) |
NCT03221114 |
1K01HL130712-01A1 |
|
September 2017 |
September 2020 |
July 2021 |
July 18, 2017 |
July 18, 2017 |
|
|
48 |
NCT02322203 |
Recruiting |
Effects of Niacin Therapy on Lipoprotein Composition and Function |
|
- Dietary Supplement: Niacin Extended Release
|
Interventional |
Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Changes in protein or lipid composition of any lipoprotein fraction and changes in vascular compliance as measured by CAVI
|
200 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02322203 |
150042 15-H-0042 |
|
December 20, 2014 |
April 7, 2019 |
July 3, 2019 |
December 23, 2014 |
March 2, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
49 |
NCT03372733 |
Recruiting |
Dietary Omega-7 Palmitoleic Acid-Rich Oil on Lipoprotein Metabolism and Satiety in Adults |
|
- Drug: control olive oil (COO)
- Drug: palmitoleate-rich oil (PLO)
|
Interventional |
Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- changes in the LDL-cholesterol levels
- changes in TC, TG, HDL-C, and other lipids, lipoprotein particle number, HDL functional test (i.e. efflux study) composition and size,changes in apetite and/or satiety
|
70 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT03372733 |
180019 18-H-0019 |
|
March 19, 2018 |
July 31, 2020 |
July 31, 2020 |
December 14, 2017 |
March 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
50 |
NCT02549664 |
Recruiting |
Exercise in Genetic Cardiovascular Conditions |
- Hypertrophic Cardiomyopathy
- Long QT Syndrome
|
|
Observational |
|
- Yale University
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Composite risk of death, cardiac arrest, ventricular arrhythmias, or syncope in individuals with HCM or LQTS who are participating in moderate or vigorous exercise and in sedentary individuals.
- Emotional Quality of Life assessed using Pediatric Cardiac Quality of Life Inventory (Pcqli)
- Physical Quality of Life assessed using Pediatric Quality of Life Inventory (PedsQL)
- Physical Quality of Life assessed using Health Status Questionnaire (SF36) Quality of Life for Adults
|
4286 |
All |
8 Years to 60 Years (Child, Adult) |
NCT02549664 |
1411014982 1R01HL125918-01 |
LIVE-HCM/LQT |
May 2015 |
May 2018 |
May 2020 |
September 15, 2015 |
October 18, 2017 |
|
- University of Arizona
Tucson, Arizona, United States - Cedar Sinai/LA Cardiology
Los Angeles, California, United States - University of California Irvine
Orange, California, United States - (and 36 more...)
|