1 |
NCT03150667 |
Recruiting |
Study Comparing Treatment Effectiveness of Guideline Indicated APT for ACS in Patients With CKD |
- Chronic Kidney Diseases
- Acute Coronary Syndrome
|
- Drug: Ticagrelor
- Drug: Clopidogrel
|
Interventional |
Phase 4 |
- North Texas Veterans Healthcare System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Occurrence of all-cause mortality, non-fatal myocardial infarction (MI), or ischemic stroke
- Occurrence of bleeding
- Need for ischemia driven urgent coronary revascularization
- (and 2 more...)
|
220 |
All |
18 Years and older (Adult, Senior) |
NCT03150667 |
16-041 |
CPRS-CKD |
April 10, 2017 |
April 30, 2019 |
April 30, 2020 |
May 12, 2017 |
January 25, 2018 |
|
- Durham VA Medical Center
Durham, North Carolina, United States - VA North Texas Health Care System
Dallas, Texas, United States
|
2 |
NCT02277613 |
Recruiting |
A Phase 2 Trial of AMI MultiStem® Therapy in Subjects With Non-ST Elevation Acute Myocardial Infarction |
|
- Biological: AMI MultiStem cells
- Other: Sham
|
Interventional |
Phase 2 |
- Athersys, Inc
- National Heart, Lung, and Blood Institute (NHLBI)
|
Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Incidence and severity of adverse events
- To assess the effects of AMI MultiStem therapy on cardiac function
- To assess the incidence of Major Adverse Cardiovascular Events (MACE)
|
90 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02277613 |
B02-02 1R44HL117572-01A1 |
MI-NSTEMI |
June 2015 |
December 2018 |
August 2019 |
October 29, 2014 |
February 5, 2018 |
|
- Birmingham, Alabama, United States
- Huntsville, Alabama, United States
- Los Angeles, California, United States
- (and 8 more...)
|
3 |
NCT03449888 |
Not yet recruiting |
Arm Exercise Versus Pharmacologic Stress Testing for Clinical Outcome |
- Veterans Referred to the St. Louis VAMC Stress Tes
|
- Procedure: Regadenoson myocardial perfusion imaging stress test
- Procedure: Arm exercise electrocardiographic stress test
- Procedure: Treadmill electrocardiographic stress test
- Procedure: Coronary artery calcium score and cardiac computed tomographic angiography
|
Observational |
|
- VA Office of Research and Development
- VA St. Louis Health Care System
|
U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Composite of cardiovascular mortality, myocardial infarction, and 90-day post-stress test coronary artery revascularization
- All-cause mortality
- Cardiovascular mortality
|
300 |
All |
21 Years to 100 Years (Adult, Senior) |
NCT03449888 |
CARA-008-17F 1 101 CX001345-01A3 |
ArmCrank |
July 1, 2018 |
June 30, 2023 |
June 30, 2023 |
February 28, 2018 |
April 4, 2018 |
|
- St. Louis VA Medical Center John Cochran Division, St. Louis, MO
Saint Louis, Missouri, United States
|
4 |
NCT02594111 |
Recruiting |
Colchicine in Percutaneous Coronary Intervention |
- Coronary Artery Disease
- Acute Coronary Syndrome
|
- Drug: Colchicine vs Placebo
|
Interventional |
Phase 4 |
- VA Office of Research and Development
- New York University School of Medicine
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Peri-procedural myocardial necrosis
- all-cause mortality, non-fatal MI, or target vessel revascularization (TVR)
- all-cause mortality, non-fatal MI, or TVR
- Peri-procedural myocardial infarction (MI)
|
800 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02594111 |
CARB-025-15S |
|
June 3, 2013 |
December 31, 2019 |
December 31, 2019 |
November 2, 2015 |
December 26, 2017 |
|
- Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY
New York, New York, United States
|
5 |
NCT02195193 |
Recruiting |
Integrating Depression Care in Acute Coronary Syndromes Care in China |
- Acute Coronary Syndromes
- Depression
|
- Other: Integrated care model for ACS and depression
|
Interventional |
Not Applicable |
- The George Institute for Global Health, China
- National Institute of Mental Health (NIMH)
- Peking University Sixth Hospital
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Changes in mean Patient Health Questionnaire-9 (PHQ-9) score from baseline to 6 months
- Changes in mean PHQ-9 score from baseline to 12 months
- Incidence of Major Adverse Cardiovascular Events (MACE)
- (and 2 more...)
|
4000 |
All |
20 Years to 79 Years (Adult, Senior) |
NCT02195193 |
I-CARE R01MH100332 |
I-Care |
November 2014 |
January 2018 |
January 2018 |
July 21, 2014 |
August 18, 2016 |
|
- The George Institute for Global Health, China
Haidian, Beijing, China
|
6 |
NCT02915198 |
Not yet recruiting |
Investigation of Metformin in Pre-Diabetes on Atherosclerotic Cardiovascular OuTcomes |
- Prediabetic State
- Atherosclerosis
- Metformin
|
- Drug: Metformin XR
- Drug: Placebo
|
Interventional |
Phase 4 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Time in days to death, non-fatal myocardial infarction, stroke, hospitalization for unstable angina, or symptom-driven coronary revascularization
- Time in days to Cardiovascular Outcomes
- Time in days to Oncologic Outcome
- Time in days to Diabetes Outcome
|
7868 |
All |
18 Years and older (Adult, Senior) |
NCT02915198 |
2002 |
VA-IMPACT |
June 1, 2018 |
November 30, 2024 |
November 30, 2024 |
September 26, 2016 |
March 29, 2018 |
|
- Phoenix VA Health Care System, Phoenix, AZ
Phoenix, Arizona, United States - VA Loma Linda Healthcare System, Loma Linda, CA
Loma Linda, California, United States - VA Long Beach Healthcare System, Long Beach, CA
Long Beach, California, United States - (and 8 more...)
|
7 |
NCT00590291 |
Recruiting |
Molecular Determinants of Coronaruy Artery Disease |
- Coronary Artery Disease
- Arteriovenous Malformations
- Myocardial Infarction
|
|
Observational |
|
- The Cleveland Clinic
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Family-Based
- Time Perspective: Retrospective
|
- Coronary Artery Disease
- Arteriovenous Malformation
- Myocardial Infarction
|
2980 |
All |
45 Years and older (Adult, Senior) |
NCT00590291 |
GeneQuest IRB4333 1R01HL121358 |
GeneQuest |
January 1995 |
April 2018 |
April 2018 |
January 10, 2008 |
February 3, 2017 |
|
- Cleveland Clinic
Cleveland, Ohio, United States
|
8 |
NCT01931852 |
Recruiting |
Cardiac Magnetic Resonance Imaging Strategy for the Management of Patients With Acute Chest Pain and Detectable to Elevated Troponin |
- Acute Coronary Syndrome
- Chest Pain
|
- Procedure: Cardiac MRI
- Other: ACC/AHA Guideline adherent care
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Institutes of Health (NIH)
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Reduction in composite death, nonfatal myocardial infarction (MI), cardiac-related hospital readmissions, and cardiac-related Emergency Department (ED) visits.
- Reduction in invasive angiography.
- Reduction in coronary revascularization.
- Reduction in recurrent cardiac testing.
|
312 |
All |
21 Years and older (Adult, Senior) |
NCT01931852 |
IRB00022322 1R01HL118263-01A1 |
CMR-IMPACT |
September 2013 |
June 2019 |
August 2019 |
August 29, 2013 |
December 5, 2017 |
|
- William Beaumont Hospital
Royal Oak, Michigan, United States - University of Mississippi Medical Center
Jackson, Mississippi, United States - Wake Forest Baptist Medical Center
Winston-Salem, North Carolina, United States - The Ohio State University Wexner Medical Center
Columbus, Ohio, United States
|
9 |
NCT02733185 |
Recruiting |
Trial to Assess Chelation Therapy 2 |
- Diabetes
- Myocardial Infarction
|
- Drug: disodium EDTA
- Dietary Supplement: Oral Multi Vitamins/Minerals (OMVM)
- Drug: Placebo disodium EDTA
- Dietary Supplement: Placebo Oral Multi Vitamins/Minerals (OMVM)
|
Interventional |
Phase 3 |
- Mt. Sinai Medical Center, Miami
- National Center for Complementary and Integrative Health (NCCIH)
- National Heart, Lung, and Blood Institute (NHLBI)
- Duke Clinical Research Institute
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- A composite of all-cause mortality, myocardial infarction, stroke, coronary revascularization, or hospitalization for unstable angina
|
1200 |
All |
50 Years and older (Adult, Senior) |
NCT02733185 |
AT009149-01 UH3AT009149 |
TACT2 |
October 2016 |
August 2021 |
December 2021 |
April 11, 2016 |
February 1, 2018 |
|
- Mount Sinai Medical Center
Miami Beach, Florida, United States
|
10 |
NCT02981407 |
Recruiting |
Myocardial Ischemia and Transfusion |
- Myocardial Infarction
- Anemia
|
- Biological: Red Blood Cell Transfusion
|
Interventional |
Phase 3 |
- Rutgers, The State University of New Jersey
- University of Pittsburgh
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Composite outcome of all-cause mortality or nonfatal myocardial reinfarction
- All-cause mortality
- Myocardial reinfarction
- Composite of all-cause mortality, nonfatal myocardial reinfarction, ischemia driven unscheduled coronary revascularization, or readmission to the hospital for ischemic cardiac diagnosis
|
3500 |
All |
18 Years and older (Adult, Senior) |
NCT02981407 |
Pro20160000722 1U01HL133817-01 |
MINT |
April 25, 2017 |
March 2021 |
April 2021 |
December 5, 2016 |
December 26, 2017 |
|
- Danbury Hospital
Danbury, Connecticut, United States - Mount Sinai Medical Center
Miami, Florida, United States - Rush University Medical Center
Chicago, Illinois, United States - (and 30 more...)
|
11 |
NCT03229941 |
Recruiting |
Transfusion Trigger After Operations in High Cardiac Risk Patients |
- Myocardial Infarction
- Coronary Revascularization
- Acute Renal Failure
|
- Procedure: Blood Transfusion
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Other
|
- A composite endpoint of postoperative infectious complications at 90 days post-randomization: Infectious complications will include wound infections, pneumonia, and sepsis.
- A composite endpoint of cardiac complications (other than MI) at 90 days post-randomization: Cardiac complications will include new cardiac arrhythmias that necessitate new treatment, new or worsening congestive heart failure (CHF), and cardiac arrest no
- All-cause mortality at 1 year after randomization.
- (and 2 more...)
|
3070 |
All |
18 Years and older (Adult, Senior) |
NCT03229941 |
599 |
TOP |
February 5, 2018 |
February 28, 2022 |
February 28, 2022 |
July 26, 2017 |
April 19, 2018 |
|
- Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR
Little Rock, Arkansas, United States - North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States - James A. Haley Veterans' Hospital, Tampa, FL
Tampa, Florida, United States - (and 4 more...)
|
12 |
NCT03413423 |
Recruiting |
Post Acute Cardiac Event Smoking (PACES) Study |
- Acute Coronary Syndrome
- Tobacco Use
|
- Behavioral: BAT-CS
- Behavioral: Smoking Cessation and Health & Wellness
|
Interventional |
Not Applicable |
- Minneapolis Medical Research Foundation
- Minneapolis Heart Institute Foundation
- The Miriam Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- 7-day point prevalence abstinence from smoking
- Depression Symptoms
- Continuous Abstinence From Smoking Since Hospital Discharge
- (and 10 more...)
|
324 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT03413423 |
17-4375 1R01HL136327 |
|
January 29, 2018 |
January 29, 2022 |
January 29, 2026 |
January 29, 2018 |
January 31, 2018 |
|
- Hennepin County Medical Center
Minneapolis, Minnesota, United States
|
13 |
NCT01621594 |
Recruiting |
Evaluating New Radiation Techniques for Cardiovascular Imaging |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Compare time-to-first cardiovascular events (revascularization more than 90 days after CTA, hospitalization, non-fatal myocardial infarction, stroke) in subjects with greater than or equal to 50% coronary stenosis vs. <50% stenosis.
- Survival analysis of subjects identified by CT with significant coronary artery disease (greater than or equal to 50% stenosis) vs. subjects without significant coronary artery disease (<50% stenosis).
- Estimate diagnostic accuracy of cardiovascular evaluations using new CT technology vs. invasive angiography and versus stress perfusion MRI.
|
3000 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT01621594 |
120141 12-H-0141 |
|
May 24, 2012 |
|
|
June 18, 2012 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
14 |
NCT02121158 |
Recruiting |
Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly |
- Cardiomyopathy
- Coronary Artery Disease
- Congestive Heart Failure
- Myocardial Infarction
|
- Device: Implantable Cardioverter Defibrillator
- Other: Optimal Medical Therapy
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
100 |
All |
70 Years and older (Senior) |
NCT02121158 |
592 |
I-70 |
August 7, 2015 |
August 1, 2018 |
August 1, 2019 |
April 23, 2014 |
January 23, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States - Washington DC VA Medical Center, Washington, DC
Washington, District of Columbia, United States - North Florida/South Georgia Veterans Health System, Gainesville, FL
Gainesville, Florida, United States - (and 3 more...)
|
15 |
NCT03417388 |
Recruiting |
Women's IschemiA TRial to Reduce Events In Non-ObstRuctive CAD |
|
- Drug: High dose potent statin
- Drug: Evolocumab
- Drug: ACE-I (lisinopril) or ARB (losartan)
- (and 3 more...)
|
Interventional |
Phase 4 |
- University of Florida
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- All Cause Death incidents reported between the two groups
- Non-fatal myocardial infarction (MI) incidents reported between the two groups
- Stroke/TIA incidents reported between the two groups
- (and 2 more...)
|
4422 |
Female |
18 Years to 100 Years (Adult, Senior) |
NCT03417388 |
IRB201701142 -A PR161603 |
WARRIOR |
February 9, 2018 |
December 30, 2021 |
December 30, 2022 |
January 31, 2018 |
February 14, 2018 |
|
- Family Medicine at Eastside Community Practice
Gainesville, Florida, United States - Family Medicine at Hampton Oaks Medical Plaza (Adults and Peds)
Gainesville, Florida, United States - Internal Medicine at Tower Hill
Gainesville, Florida, United States - (and 8 more...)
|
16 |
NCT00540761 |
Recruiting |
Identifying Vulnerable Plaques in Blood Vessels of the Heart Using a New Imaging Technique |
- Coronary Arteriosclerosis
|
|
Interventional |
Phase 1 |
- Massachusetts General Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Determine prevalence of vulnerable plaques
- Safety of OFDI imaging
|
320 |
All |
21 Years and older (Adult, Senior) |
NCT00540761 |
2005-P000646 R01HL076398 |
|
May 2007 |
December 2018 |
December 2018 |
October 8, 2007 |
January 25, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Lahey Clinic
Burlington, Massachusetts, United States - Columbia Presbyterian Medical Center
New York, New York, United States
|
17 |
NCT03014414 |
Recruiting |
Stanford Healthy Heart Study |
|
- Behavioral: Fun First
- Behavioral: Weight Watchers
|
Interventional |
Not Applicable |
- Stanford University
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Proportion of participants who lose a clinically significant amount of initial body weight AND maintain it during the trial (i.e., Lose >=7% of their initial body weight from 0-12 months AND gain <=5 lbs from 12-36 months), assessed by clinic scales
- Proportion of participants who lose a clinically significant amount of initial body weight AND maintain it during the trial (Lose >=7% of their initial body weight from 0-12 months AND gain <=5 lbs from 12-36 months), assessed by cellular scales
- Change in systolic blood pressure from 0-36 months
|
346 |
All |
21 Years and older (Adult, Senior) |
NCT03014414 |
37586 R01HL128666 |
|
March 4, 2017 |
June 2020 |
July 2020 |
January 9, 2017 |
April 18, 2018 |
|
- Stanford University School of Medicine
Palo Alto, California, United States
|
18 |
NCT02055209 |
Recruiting |
Genomics, Environmental Factors and Social Determinants of Cardiovascular Disease in African-Americans Study (GENE-FORECAST) |
- Hypertension
- Cardiovascular Disease
|
|
Observational |
|
- National Human Genome Research Institute (NHGRI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- To develop a novel genomic science resource for defining the functional significance and human biology consequences of ancestry-related genomic variation in AA.
|
2019 |
All |
21 Years to 65 Years (Adult) |
NCT02055209 |
140048 14-HG-0048 |
|
February 4, 2014 |
June 4, 2018 |
June 4, 2018 |
February 5, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
19 |
NCT03118752 |
Recruiting |
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety |
- Acute Coronary Syndrome
- Heart Failure
- Depression
- (and 2 more...)
|
- Behavioral: Collaborative Care
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in physical function
- Change in generic health-related quality of life
- Change in disease-specific health-related quality of life
- (and 12 more...)
|
260 |
All |
18 Years and older (Adult, Senior) |
NCT03118752 |
2016P002870 1R01HL133149-01A1 |
|
October 16, 2017 |
September 30, 2022 |
September 30, 2022 |
April 18, 2017 |
April 4, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Salem Hospital
Salem, Massachusetts, United States
|
20 |
NCT00001168 |
Recruiting |
Evaluation of Lipoproteins |
- Hyperlipidemia
- Hyperlipoproteinemia
- Hypolipoproteinemia
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
2000 |
All |
Child, Adult, Senior |
NCT00001168 |
790100 79-H-0100 |
|
August 6, 1979 |
|
|
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
21 |
NCT03236441 |
Recruiting |
Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury |
- Contrast-induced Acute Kidney Injury
|
- Device: RIPC
- Device: Sham-RIPC
|
Interventional |
Not Applicable |
- Oladipupo Olafiranye
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- University of Pittsburgh
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Contrast-induced acute kidney injury
- Biomarkers study
|
110 |
All |
18 Years and older (Adult, Senior) |
NCT03236441 |
PRO17070546 1R21DK113486-01A1 |
BRICK |
March 5, 2018 |
August 30, 2020 |
August 30, 2020 |
August 2, 2017 |
April 2, 2018 |
|
- University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States
|
22 |
NCT02641496 |
Recruiting |
Cognitive Behavioral Therapy to Increase CPAP Adherence in Veterans With PTSD |
- Obstructive Sleep Apnea
- PTSD
- Posttraumatic Stress Disorder
|
- Behavioral: CBT-OSA
- Behavioral: Sleep Education
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Supportive Care
|
- Time in hours of "mask-on" CPAP usage per night
- Functional Outcomes of Sleep Questionnaire (FOSQ)
- California Verbal Learning Test, Second Edition (CVLT-II)
- PTSD Checklist for DSM-5 (PCL-5)
|
144 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02641496 |
D1799-R |
|
January 1, 2017 |
December 31, 2020 |
December 31, 2021 |
December 29, 2015 |
March 2, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
23 |
NCT02185417 |
Recruiting |
Diuretic Comparison Project |
|
- Drug: Hydrochlorothiazide (HCTZ)
- Drug: Chlorthalidone
|
Interventional |
Phase 3 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to major cardiovascular event
- Time to event for each component of the composite primary outcome and additional cardiovascular events
- All Deaths
- (and 8 more...)
|
13500 |
All |
65 Years and older (Adult, Senior) |
NCT02185417 |
597 |
DCP |
June 15, 2016 |
October 15, 2022 |
April 15, 2023 |
July 9, 2014 |
January 12, 2018 |
|
- VA Greater Los Angeles Healthcare System, West Los Angeles, CA
West Los Angeles, California, United States - VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States - Minneapolis VA Health Care System, Minneapolis, MN
Minneapolis, Minnesota, United States - (and 2 more...)
|
24 |
NCT02034422 |
Recruiting |
Understanding the Exercise-Hypertension Paradox |
|
- Dietary Supplement: Oral Antioxidant
- Other: Exercise rehabilitation
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
|
72 |
All |
40 Years to 60 Years (Adult) |
NCT02034422 |
O1215-W 1IK2RX001215 |
|
February 1, 2014 |
February 1, 2019 |
December 31, 2019 |
January 13, 2014 |
January 8, 2018 |
|
- VA Salt Lake City Health Care System, Salt Lake City, UT
Salt Lake City, Utah, United States
|
25 |
NCT01399385 |
Recruiting |
New Heart Imaging Techniques to Evaluate Possible Heart Disease |
- Healthy
- Obesity
- Diabetes
- (and 2 more...)
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- Coronary segmental involvement scores
|
99999999 |
All |
18 Years and older (Adult, Senior) |
NCT01399385 |
110168 11-DK-0168 |
|
July 20, 2011 |
|
|
July 21, 2011 |
April 6, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
26 |
NCT02338999 |
Recruiting |
Role of PPAR-y Agonists in Immunomodulation and Vascular Prevention in SLE (PPAR-SLE) |
- Systemic Lupus Erthematosus
|
- Radiation: PET/CT
- Drug: Pioglitazone
- Procedure: Vascular function studies
|
Interventional |
Phase 1 Phase 2 |
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Vascular function and inflammation
- Lupus disease activity and immmunomodulation
|
70 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02338999 |
150060 15-AR-0060 |
|
January 14, 2015 |
January 31, 2020 |
January 31, 2020 |
January 15, 2015 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
27 |
NCT02694185 |
Recruiting |
Secondary Event Prevention Using Population Risk Management After PCI and for Anti-Rheumatic Medications |
- Myocardial Ischemia
- Rheumatic Diseases
|
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Proportion of Days Covered (PDC)
- Cardiovascular Events (CVE)
- Incremental Cost Effectiveness (ICE)
|
4800 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT02694185 |
IIR 14-048 16-1419 1 I01 HX001604-01A2 |
SEPPRMACI-ARM |
October 1, 2016 |
December 31, 2019 |
March 31, 2020 |
February 29, 2016 |
April 19, 2018 |
|
- San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States - VA Eastern Colorado Health Care System, Denver, CO
Denver, Colorado, United States - Baltimore VA Medical Center VA Maryland Health Care System, Baltimore, MD
Baltimore, Maryland, United States - (and 2 more...)
|
28 |
NCT02107976 |
Recruiting |
Famine From Feast: Linking Vitamin C, Red Blood Cell Fragility, and Diabetes |
|
|
Observational |
|
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Whether RBCs have low vitamin C concentrations in patients with poorly controlled diabetes, as measured by HBa1C
|
50 |
All |
18 Years to 60 Years (Adult) |
NCT02107976 |
140060 14-DK-0060 |
|
April 5, 2014 |
February 1, 2019 |
February 1, 2019 |
April 9, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
29 |
NCT02081638 |
Recruiting |
Elite Controller and ART-treated HIV+ Statin Versus ASA Treatment Intervention Study |
|
- Drug: Aspirin 81 mg daily
- Drug: Atorvastatin 40 mg daily
|
Interventional |
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- The primary end point will be change of sCD14 from Month 3 to Month 12 in the two groups combined (EC and ART <50).
- Changes in soluble biomarkers (sCD14, IL-6, D-dimer, hsCRP, sCD163, sTF as well as other relevant markers of inflammation and coagulation) in EC and ART <50 groups treated with ASA or ATV, independently within each group and arm and with grou...
- Changes in T cell activation (measured by HLA-DR/CD38 co- expression), monocyte immune activation (measured by activated monocyte subsets expressing either CD14++CD16+ and CD14varCD16+ and markers of activation, CCR5 and TF, and migration, CCR2 ...
- Changes in MR imaging of carotids after 9 months of statin or ASA in each group and both groups combined.
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT02081638 |
140039 14-I-0039 |
|
March 5, 2014 |
November 30, 2019 |
November 30, 2019 |
March 7, 2014 |
April 6, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - Hennipen County Medical Center
Minneapolis, Minnesota, United States
|
30 |
NCT00353782 |
Recruiting |
Causes and Natural History of Dyslipidemias |
|
|
Observational |
|
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
99999999 |
All |
2 Years and older (Child, Adult, Senior) |
NCT00353782 |
030280 03-H-0280 |
|
September 15, 2003 |
|
|
July 19, 2006 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
31 |
NCT00082745 |
Recruiting |
Genetic Analysis in Identifying Late-Occurring Complications in Childhood Cancer Survivors |
- Cancer Survivor
- Cardiovascular Complication
- Malignant Childhood Neoplasm
|
- Other: Laboratory Biomarker Analysis
- Other: Questionnaire Administration
|
Observational |
|
- Children's Oncology Group
- National Cancer Institute (NCI)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Retrospective
|
- Rate of adverse events (cardiac dysfunction, AVN, ischemic stroke, and SMN using a matched case-control)
- Frequency of mutations or polymorphisms in specific candidate genes in cases and controls
- Crude disease-exposure
|
8100 |
All |
up to 21 Years (Child, Adult) |
NCT00082745 |
ALTE03N1 NCI-2011-03822 COG-ALTE03N1 CDR0000360708 U10CA095861 U10CA180886 |
|
March 2004 |
January 2100 |
|
May 19, 2004 |
August 21, 2017 |
|
- Children's Hospital of Alabama
Birmingham, Alabama, United States - University of Alabama at Birmingham Cancer Center
Birmingham, Alabama, United States - Arkansas Children's Hospital
Little Rock, Arkansas, United States - (and 152 more...)
|
32 |
NCT00004847 |
Recruiting |
Diagnosis of Pheochromocytoma |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
- To investigate the use of radiopharmaceutical tracer, F(18)-FLT for PET/CT scan in evaluating cellular proliferative behavior of various genetically inherited and sporadic pheochromocytomas and paragagliomas in adult patients.
|
2400 |
All |
7 Years and older (Child, Adult, Senior) |
NCT00004847 |
000093 00-CH-0093 |
|
March 1, 2000 |
|
|
March 3, 2000 |
March 29, 2018 |
|
- Johns Hopkins University
Baltimore, Maryland, United States - National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
33 |
NCT01258231 |
Recruiting |
Identification of Genomic Predictors of Adverse Events After Cardiac Surgery |
- Heart; Dysfunction Postoperative, Cardiac Surgery
- Genetic Predisposition to Disease
- Atrial Fibrillation
- (and 2 more...)
|
|
Observational |
|
- Brigham and Women's Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
- Texas Heart Institute
- University of Texas Southwestern Medical Center
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Atrial fibrillation
- Death
- Renal dysfunction
|
4000 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT01258231 |
2000P001639 5R01HL098601 |
CABGGenomics |
August 2000 |
August 2020 |
August 2020 |
December 10, 2010 |
October 4, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - UT Southwestern Medical Center
Dallas, Texas, United States - Department Texas Heart Institute at St. Luke's Episcopal Hospital
Houston, Texas, United States
|
34 |
NCT02939469 |
Not yet recruiting |
Skin Sympathetic Nerve Activity and Cardiac Arrhythmias |
- Sympathetic Nerve Activity
|
- Other: Physiologic maneuvers
|
Interventional |
Phase 2 |
- Cedars-Sinai Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Chane in Sympathetic nerve activity
|
42 |
All |
18 Years to 45 Years (Adult) |
NCT02939469 |
Pro 42959 |
|
November 2016 |
November 2017 |
December 2017 |
October 20, 2016 |
October 20, 2016 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
35 |
NCT03022669 |
Recruiting |
Mobile Health Strategies for Veterans |
|
- Behavioral: Text Message
- Behavioral: Mobile Application
- Other: Website
|
Interventional |
Phase 2 |
- University of California, San Francisco
- San Francisco Veterans Affairs Medical Center
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
|
225 |
All |
21 Years and older (Adult, Senior) |
NCT03022669 |
1IK3HX002055-01A1 |
|
December 2016 |
November 2020 |
November 2020 |
January 16, 2017 |
January 16, 2017 |
|
- John Muir Medical Center
Concord, California, United States - San Francisco Veterans Affairs Medical Center
San Francisco, California, United States
|
36 |
NCT00950118 |
Recruiting |
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science |
- Congenital Diaphragmatic Hernia
|
|
Observational |
|
- Columbia University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Percentage of patients with a genetic diagnosis
- Developmental outcomes at 2 and 5 years of age
- Percentage of patients with pulmonary hypertension
|
2020 |
All |
Child, Adult, Senior |
NCT00950118 |
AAAB2063 R01HD057036 |
DHREAMS |
June 2005 |
November 2025 |
November 2025 |
July 31, 2009 |
January 29, 2018 |
|
- University of Michigan/ CS Mott Children's Hospital
Ann Arbor, Michigan, United States - Washington University Medical Center/ St. Louis Children's Hospital
Saint Louis, Missouri, United States - Children's Hospital of Omaha/ University of Nebraska
Omaha, Nebraska, United States - (and 9 more...)
|
37 |
NCT02163408 |
Recruiting |
3D Multi-Contrast Atherosclerosis Characterization of the Carotid Artery |
|
- Other: MRI with/without contrast
|
Observational |
|
- Cedars-Sinai Medical Center
- National Heart, Lung, and Blood Institute (NHLBI)
- American Heart Association
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Image quality score
- Adverse plaque characteristics detection
- Image contrast-to-noise ratio
|
140 |
All |
18 Years and older (Adult, Senior) |
NCT02163408 |
35762 2R01HL096119-05 |
|
June 24, 2014 |
June 2019 |
June 2019 |
June 13, 2014 |
March 27, 2018 |
|
- Cedars-Sinai Medical Center
Los Angeles, California, United States
|
38 |
NCT03419325 |
Recruiting |
A Genomic Approach for Clopidogrel in Caribbean Hispanics |
- Cardiovascular Disease (CVD)
- Stroke
- Acute Coronary Syndrome
- (and 3 more...)
|
- Genetic: CYP2C19 test
- Diagnostic Test: P2RY12 assay
|
Interventional |
Not Applicable |
- University of Puerto Rico
- National Institute on Minority Health and Health Disparities (NIMHD)
- Icahn School of Medicine at Mount Sinai
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Major adverse cardiovascular events (MACE) reductions
- number of patients with treatment-related cardiovascular (CV) death
- number of patients with treatment-related stent thrombosis
- Bleeding
|
250 |
All |
21 Years and older (Adult, Senior) |
NCT03419325 |
A4070417 2U54MD007600-31 |
|
January 17, 2018 |
June 30, 2020 |
June 30, 2022 |
February 1, 2018 |
February 1, 2018 |
|
- University Hospital at Carolina
Carolina, Puerto Rico - Cardiovascular Hospital of Puerto Rico and the Caribbean
San Juan, Puerto Rico
|
39 |
NCT03437798 |
Recruiting |
Genomic Determinants and Shared Genetic Pathways of Periodontal Disease |
- Periodontal Diseases
- Diabetes
- Osteoporosis
- Cardiovascular Risk Factor
|
|
Observational |
|
- Tufts University
- Brigham and Women's Hospital
- National Institute of Dental and Craniofacial Research (NIDCR)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Other
|
- Validity of self-reported periodontal disease
- Correlation of CDC-AAP periodontal condition questions vs. periodontal disease diagnosis
|
360 |
Female |
45 Years to 100 Years (Adult, Senior) |
NCT03437798 |
HH1804 1K23DE026804-01 |
|
January 30, 2018 |
May 31, 2022 |
August 31, 2022 |
February 19, 2018 |
February 19, 2018 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States
|
40 |
NCT02045459 |
Recruiting |
Microvascular Disease Exercise Trial |
- Coronary Microvascular Disease
|
- Behavioral: Exercise Program
- Drug: Medical Therapy
|
Interventional |
Phase 1 Phase 2 |
- University of Virginia
- Astellas Pharma Global Development, Inc.
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
- Change in MPR on CMR imaging from baseline with intensive medical therapy + supervised exercise versus intensive medical therapy alone.
- Incremental change in MPR with exercise over intensive medical therapy alone in the exercise subgroup
- Identification of reduced MPR (<2.0 ml/g/min) and borderline reduced MPR
|
165 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02045459 |
16821 1K23HL119620-01 |
MOVE |
May 2014 |
July 2018 |
July 2018 |
January 24, 2014 |
May 25, 2016 |
|
- University of Virginia
Charlottesville, Virginia, United States - University of Virginia
Charlottesville, Virginia, United States
|
41 |
NCT02787044 |
Recruiting |
INfluenza Vaccine to Effectively Stop Cardio Thoracic Events and Decompensated Heart Failure |
- Heart Failure
- Myocardial Infarction
|
- Biological: High Dose Trivalent Influenza Vaccine
- Biological: Standard Dose Quadrivalent Influenza Vaccine
|
Interventional |
Phase 4 |
- Brigham and Women's Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
- University of Wisconsin, Madison
- (and 3 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- All-Cause Death or Cardiopulmonary Hospitalization
- Total cardiopulmonary hospitalizations or death
- Death or cardiopulmonary hospitalization within each influenza season
- (and 4 more...)
|
9300 |
All |
18 Years and older (Adult, Senior) |
NCT02787044 |
2015P001823 U01HL130163 |
INVESTED |
August 2016 |
August 2020 |
February 2021 |
June 1, 2016 |
September 12, 2017 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - Boston/West Roxbury VA Hospital
West Roxbury, Massachusetts, United States - University of Wisconsin
Madison, Wisconsin, United States - University of Toronto
Toronto, Ontario, Canada
|
42 |
NCT02188381 |
Recruiting |
The Role of Gut Microbiota in Hypertension |
|
- Other: Stool Sample and Blood Sample
|
Observational |
|
- University of Florida
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Characterize gut microbiota composition at phylum level
- Characterize gut microbiota composition at genus level
- Reduction in BP is associated with changes in gut microbiota composition in RH subjects.
|
398 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02188381 |
IRB201400233-N 1R01HL132448-01 |
|
July 2014 |
December 2018 |
December 2018 |
July 11, 2014 |
April 5, 2018 |
|
- Cardiovascular Clinic at UF Health
Gainesville, Florida, United States
|
43 |
NCT03331380 |
Recruiting |
Technical Development of Cardiovascular Magnetic Resonance Imaging (CMR) Using a Low Specific Absorption Rate (SAR) Scanner System |
|
- Device: MRI scan x 1- Healthy volunteer
- Device: MRI scan x 2- Healthy volunteer
- Device: MRI scan x 2- CAD patients
- Device: MRI scan x 2- non-CAD patients
|
Interventional |
Phase 1 Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Technical feasibility and Non-inferiority of the above measurements and examinations obtained using low SAR CMR versus commercial CMR in healthy volunteers and in patients with heart disease
- Numerous exploratory secondary endpoints are sought around the listed measurements across MRI systems and disease states
|
460 |
All |
18 Years and older (Adult, Senior) |
NCT03331380 |
180011 18-H-0011 |
|
January 5, 2018 |
May 30, 2018 |
May 30, 2019 |
November 6, 2017 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
44 |
NCT01742117 |
Recruiting |
Tailored Antiplatelet Therapy Following PCI |
- Coronary Artery Disease
- Acute Coronary Syndrome
- Stenosis
|
- Drug: Clopidogrel
- Drug: Ticagrelor
- Genetic: Retrospective Genotype testing
- Genetic: Prospective Genotype testing
|
Interventional |
Phase 4 |
- Mayo Clinic
- Spartan Bioscience Inc.
- Applied Health Research Centre
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Occurrence of the a major adverse cardiovascular event (MACE)
- Number of subjects with reduced function CYP2C19 allele(s) who have major or minor bleeding
|
5270 |
All |
18 Years and older (Adult, Senior) |
NCT01742117 |
11-006837 5U01HL128606 |
TAILOR-PCI |
May 2013 |
September 2019 |
March 2020 |
December 5, 2012 |
November 21, 2017 |
|
- Mayo Clinic in Arizona
Scottsdale, Arizona, United States - Sharp HealthCare
San Diego, California, United States - Zuckerberg San Francisco General
San Francisco, California, United States - (and 37 more...)
|
45 |
NCT02561000 |
Recruiting |
Safety of PZ-128 in Subjects Undergoing Non-Emergent Percutaneous Coronary Intervention |
- Arterial Occlusive Diseases
- Coronary Artery Disease
- Coronary Disease
- (and 5 more...)
|
- Drug: PZ-128
- Drug: Placebo
|
Interventional |
Phase 2 |
- Tufts Medical Center
- National Heart, Lung, and Blood Institute (NHLBI)
- RTI International
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incidence of bleeding through 30 days following treatment in subjects undergoing cardiac catheterization/percutaneous coronary intervention
- Incidence of major adverse cardiac events
|
600 |
All |
18 Years and older (Adult, Senior) |
NCT02561000 |
TMC-PZ128-02 P50HL110789 |
TRIP-PCI |
April 2016 |
March 2019 |
June 2019 |
September 25, 2015 |
June 26, 2017 |
|
- Tufts Medical Center
Boston, Massachusetts, United States - UMass Memorial Medical Center
Worcester, Massachusetts, United States - Inova Heart and Vascular Institute, Inova Fairfax Hospital
Falls Church, Virginia, United States
|
46 |
NCT02927249 |
Recruiting |
Aspirin in Preventing Recurrence of Cancer in Patients With HER2 Negative Stage II-III Breast Cancer After Chemotherapy, Surgery, and/or Radiation Therapy |
- Node Positive HER2 Negative Breast Cancer
|
- Other: Placebo
- Drug: Aspirin
|
Interventional |
Phase 3 |
- Alliance for Clinical Trials in Oncology
- National Cancer Institute (NCI)
- United States Department of Defense
- Bayer
|
Other / NIH / U.S. Fed / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Invasive disease-free survival (iDFS)
- Overall survival (OS)
- Distant disease free survival (DDFS)
- (and 2 more...)
|
2936 |
All |
18 Years to 69 Years (Adult, Senior) |
NCT02927249 |
A011502 NCI-2016-00233 U10CA180821-01 |
|
December 2016 |
April 2021 |
|
October 7, 2016 |
April 9, 2018 |
|
- Southern Cancer Center PC-Daphne
Daphne, Alabama, United States - Southern Cancer Center PC-Mobile
Mobile, Alabama, United States - Southern Cancer Center PC-Providence
Mobile, Alabama, United States - (and 1176 more...)
|
47 |
NCT02344290 |
Recruiting |
Evaluating the Use of Pitavastatin to Reduce the Risk of Cardiovascular Disease in HIV-Infected Adults |
- HIV Infections
- Cardiovascular Diseases
|
- Drug: Pitavastatin
- Drug: Placebo
|
Interventional |
Phase 3 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Heart, Lung, and Blood Institute (NHLBI)
- Kowa Pharmaceuticals America, Inc.
- Gilead Sciences
|
NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Time to the first event of a composite of major cardiovascular events
- Time to the first of each individual component of the primary endpoint
- Time to death (all-cause mortality)
- (and 10 more...)
|
7500 |
All |
40 Years to 75 Years (Adult, Senior) |
NCT02344290 |
A5332 11960 1U01HL123339-01 1U01HL123336-01 |
REPRIEVE |
March 2015 |
April 1, 2022 |
April 1, 2022 |
January 22, 2015 |
April 13, 2018 |
|
- Alabama CRS
Birmingham, Alabama, United States - University of Arizona CRS
Tucson, Arizona, United States - University of Southern California CRS
Los Angeles, California, United States - (and 129 more...)
|
48 |
NCT02576067 |
Recruiting |
Cardiovascular Inflammation Reduction Trial - Inflammation Imaging Study |
- Vascular Inflammation
- Atherosclerotic Cardiovascular Disease
|
- Drug: Low dose methotrexate
- Drug: Placebo
|
Interventional |
Phase 3 |
- Icahn School of Medicine at Mount Sinai
- Brigham and Women's Hospital
- Massachusetts General Hospital
- (and 3 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in arterial inflammation
- Change in max target-to-background (TBR)
|
216 |
All |
18 Years and older (Adult, Senior) |
NCT02576067 |
GCO 14-1382 1R01HL128056-01A1 |
CIRT |
December 2015 |
May 2019 |
May 2019 |
October 15, 2015 |
September 28, 2017 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Icahn School of Medicine at Mount Sinai
New York, New York, United States - St. Michael's Hospital
Toronto, Ontario, Canada
|
49 |
NCT03364491 |
Recruiting |
Tranexamic Acid for the Prevention of Obstetrical Hemorrhage After Cesarean |
- Obstetrical Complications
- Hemorrhage
- Labor and Delivery
|
- Drug: Tranexamic Acid
- Drug: Placebo
|
Interventional |
Phase 3 |
- The George Washington University Biostatistics Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Maternal death or transfusion of packed red blood cells
- Estimated blood loss
- Composite of surgical or radiological interventions to control bleeding and related complications, or maternal death
- (and 18 more...)
|
11000 |
Female |
18 Years and older (Adult, Senior) |
NCT03364491 |
HD36801-TXA U10HD036801 |
TXA |
March 12, 2018 |
December 2020 |
December 2020 |
December 6, 2017 |
March 19, 2018 |
|
- University of Alabama - Birmingham
Birmingham, Alabama, United States - Northwestern University-Prentice Hospital
Chicago, Illinois, United States - Columbia University
New York, New York, United States - (and 9 more...)
|
50 |
NCT01819597 |
Recruiting |
Surgical Indirect Revascularization For Symptomatic Intracranial Arterial Stenosis |
- Intracranial Arterial Stenosis
- Intracranial Atherosclerosis
- Ischemic Stroke
- Cerebral Angiogenesis
|
- Procedure: Encephaloduroarteriosynangiosis (EDAS)
|
Interventional |
Phase 2 |
- Cedars-Sinai Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Stroke or death after enrollment
- Stroke or death in the territory of qualifying artery
- Any stroke or death
- (and 6 more...)
|
55 |
All |
30 Years to 80 Years (Adult, Senior) |
NCT01819597 |
K23NS079477-01A1 |
ERSIAS |
March 2013 |
June 2018 |
June 2018 |
March 27, 2013 |
November 1, 2017 |
|
- Cedars Sinai Medical Center
Los Angeles, California, United States
|