| 1 |
NCT00318773 |
Completed |
Short-Term Versus Long-Term Treatment for Severe Premenstrual Syndrome (PMS) |
|
|
Interventional |
Phase 4 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Penn Daily Symptom Report (DSR)
- Hamilton Depression Scale
- Quality of Life Questionnaire
- (and 2 more...)
|
174 |
Female |
18 Years to 45 Years (Adult) |
NCT00318773 |
R01HD018633 |
|
February 2002 |
December 2007 |
February 2008 |
April 27, 2006 |
February 27, 2009 |
|
- Department of Obstetrics/Gynecology, University of Pennsylvania, School of Medicine
Philadelphia, Pennsylvania, United States
|
| 2 |
NCT03278613 |
Recruiting |
Neuromodulation for Accidental Bowel Leakage |
|
|
Interventional |
Not Applicable |
- NICHD Pelvic Floor Disorders Network
- University of Alabama at Birmingham
- University of California, San Diego
- (and 8 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- St. Mark's (Vaizey) Score (PTNS vs. Sham)
- Episodes of fecal incontinence (FI) (PTNS vs. Sham)
- Accidental Bowel Leakage Symptom questionnaire (ABLe) score (PTNS vs. Sham)
- (and 16 more...)
|
359 |
Female |
18 Years and older (Adult, Senior) |
NCT03278613 |
12865-29
2U24HD069031-06
2UG1HD069013-06
5UG1HD041267-18
5UG1HD069010-07
5UG1HD069006-07
5UG1HD041261-17
5UG1HD054214-12
5UG1HD054241-12 |
NOTABLe |
February 9, 2018 |
October 2020 |
October 2020 |
September 11, 2017 |
March 21, 2018 |
|
- The University of Alabama at Birmingham
Birmingham, Alabama, United States - Kaiser Permanente -- Downey
Downey, California, United States - University of California at San Diego, UCSD Women's Pelvic Medicine Center
La Jolla, California, United States - (and 6 more...)
|
| 3 |
NCT02217462 |
Recruiting |
Pregnancy Eating Attributes Study |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- University of North Carolina, Chapel Hill
- The EMMES Corporation
|
NIH / Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Body weight
- Dietary intake
|
450 |
Female |
18 Years to 44 Years (Adult) |
NCT02217462 |
HHSN275201300015C |
PEAS |
October 2014 |
July 2018 |
|
August 15, 2014 |
August 7, 2017 |
|
- UNC Hospitals Obstetrics Clinic; Timberlylne Obstetrics & Gynecology Clinic
Chapel Hill, North Carolina, United States
|
| 4 |
NCT00340275 |
Completed |
Longitudinal Study of Vaginal Flora |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
5500 |
Female |
15 Years to 44 Years (Child, Adult) |
NCT00340275 |
999999023
OH99-CH-N023 |
|
April 14, 1999 |
|
November 18, 2010 |
June 21, 2006 |
July 2, 2017 |
|
- University of Alabama
Birmingham, Alabama, United States
|
| 5 |
NCT00455338 |
Completed |
Effect of Meal Composition on Postprandial Testosterone Concentration in Women With Polycystic Ovary Syndrome |
- Polycystic Ovary Syndrome
|
- Behavioral: Meal Composition
|
Interventional |
Not Applicable |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Testosterone
- SHBG
- Glucose
- Insulin
|
16 |
Female |
19 Years to 40 Years (Adult) |
NCT00455338 |
K24-HD0147-6 |
|
May 2005 |
|
November 2006 |
April 3, 2007 |
April 3, 2007 |
|
|
| 6 |
NCT01702935 |
Completed |
Ovarian Stem Cells From Women With Ovarian Insufficiency |
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- The immediate aim of this protocol is to characterize oogonial stem cells in patients with primary ovarian insufficiency and diminished ovarian reserve.
|
11 |
Female |
18 Years and older (Adult, Senior) |
NCT01702935 |
120212
12-CH-0212 |
|
September 19, 2012 |
|
September 21, 2017 |
October 10, 2012 |
April 19, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 7 |
NCT00246506 |
Unknown † |
Infertility Therapy for Women Age Thirty-eight and Older |
|
- Procedure: intrauterine insemination
- Procedure: in vitro fertilization
|
Interventional |
Not Applicable |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Associated complications of treatment will be described.
- Demographics and baseline variables will be collected, including: medical and reproductive, history, age, education, income, race, nutritional history, smoking history, and clinical variables related to infertility diagnosis and treatment.
|
450 |
All |
38 Years to 43 Years (Adult) |
NCT00246506 |
1R01HD044547 |
FORT-T |
July 2003 |
April 2012 |
April 2013 |
October 31, 2005 |
January 15, 2013 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States - Boston IVF
Brookline, Massachusetts, United States - Boston IVF
Quincy, Massachusetts, United States - Boston IVF
Waltham, Massachusetts, United States
|
| 8 |
NCT00332033 |
Completed |
Development of a Non-Invasive Treatment for Uterine Leiomyoma (Fibroids) |
- Uterine Leiomyoma
- Fibroids
|
|
Interventional |
Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
32 |
Female |
35 Years to 50 Years (Adult) |
NCT00332033 |
060029
06-CH-0029 |
|
May 25, 2006 |
|
February 16, 2007 |
June 1, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 9 |
NCT00556400 |
Terminated
Has Results |
Treatment of Menorrhagia in Women With Thrombocytopenia Using Platelets or Platelets and Hormones |
- Aplastic Anemia
- Menorrhagia
- Amenorrhea
|
- Drug: Lo-Ovral Oral Contraceptive Pills
- Drug: Placebo - sugar pill
|
Interventional |
Phase 1
Phase 2 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Stop Vaginal Bleeding or Spotting.
- Proportion Who Stop Uterine Bleeding by Day 14.
- Total Number of Bleeding Days During the First 7 Days.
|
1 |
Female |
12 Years to 55 Years (Child, Adult) |
NCT00556400 |
080022
08-CH-0022 |
|
November 2007 |
June 2012 |
June 2012 |
November 12, 2007 |
July 19, 2013 |
July 11, 2013 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 10 |
NCT01337778 |
Completed |
Dil Mil (Hearts Together) |
- Gender Based Violence
- Women's Health
|
- Behavioral: Primary care for Daughters-in-Law
- Behavioral: The Dil Mil Intervention
|
Interventional |
Phase 2 |
- RTI International
- St. John's Research Institute
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Incident Gender-Based Violence (GBV)
- Incident GBV
- Safety
- (and 5 more...)
|
539 |
Female |
18 Years to 85 Years (Adult, Senior) |
NCT01337778 |
1R21HD062821-01A1 |
|
August 2010 |
June 2013 |
October 2013 |
April 19, 2011 |
November 4, 2013 |
|
- St. John's Research Institute, St. John's National Academy of Health Sciences
Kormangala, Bangalore, India
|
| 11 |
NCT02032459 |
Completed |
Vitamin D and Pregnancy: Camden Study |
- Reproductive Effects
- Pregnancy
|
|
Observational |
|
- Rowan University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Maternal Vitamin D Status
- Vitamin D Status in relations to pregnancy complications
|
1141 |
Female |
18 Years and older (Adult, Senior) |
NCT02032459 |
0320070046
5R21HD058128 |
|
April 2007 |
September 2007 |
|
January 10, 2014 |
January 10, 2014 |
|
- Rowan University
Stratford, New Jersey, United States
|
| 12 |
NCT01279733 |
Completed |
Prenatal Cytogenetic Diagnosis by Array-Based Copy Number Analysis |
|
- Genetic: Microarray analysis
|
Observational |
|
- Columbia University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Detection rate of fetal cytogentic abnormalites between microarray copy number analysis and karyotype in prenatal samples
- The ability of microarray copy number analysis to identify clinically significant microdeletions and duplications not seen by standard karyotyping
- The rates of clinically significant copy number variants associated with specific prenatal conditions
|
4450 |
All |
18 Years and older (Adult, Senior) |
NCT01279733 |
AAAC8036
1R01HD055651-01 |
Microarray |
October 2008 |
October 2011 |
October 2011 |
January 19, 2011 |
August 22, 2012 |
|
- Columbia University Medical Center
New York, New York, United States
|
| 13 |
NCT00743210 |
Completed |
Oral L-Citrulline and ADMA in Pregnancy |
|
- Drug: L-citrulline
- Drug: Placebo
|
Interventional |
Phase 1 |
- University of Pittsburgh
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- To evaluate blood pressure changes in response to oral L-citrulline or placebo treatment in uncomplicated obese pregnant women during the second trimester of pregnancy.
- To evaluate the changes in plasma ADMA/L-arginine ratio, endothelial-dependent vascular function and peripheral vascular stiffness, and uterine artery Doppler resistance and flow.
|
41 |
Female |
14 Years to 40 Years (Child, Adult) |
NCT00743210 |
2P01HD030367-ARG
P01HD030367-09 |
|
January 2010 |
June 2013 |
June 2013 |
August 28, 2008 |
July 16, 2014 |
|
- Magee-Womens Hospital of UPMC
Pittsburgh, Pennsylvania, United States
|
| 14 |
NCT03317795 |
Recruiting |
Treatment of Heavy Menstrual Bleeding in Women With Uterine Fibroids |
- Heavy Menstrual Bleeding
- Menorrhagia
- Uterine Fibroids
|
- Drug: Levonorgestrel IUS
- Drug: Tranexamic Acid
|
Interventional |
Phase 4 |
- Shannon K. Laughlin-Tommaso
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Mayo Clinic
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Self-Reported Menorrhagia Scores
- Duration of Use of Assigned Treatment
- Mean Fibroid Size
- (and 4 more...)
|
160 |
Female |
25 Years to 50 Years (Adult) |
NCT03317795 |
16-008671
R21HD091337 |
|
November 14, 2017 |
June 30, 2019 |
December 31, 2019 |
October 23, 2017 |
April 3, 2018 |
|
- Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
| 15 |
NCT00995878 |
Completed |
The FIRSTT: Comparing MRgFUS(MR-guided Focused Ultrasound) Versus UAE (Uterine Artery Embolization)for Uterine Fibroids. |
- Symptomatic Uterine Leiomyomas
- Fibroids
- Uterine Fibroids
- Myomas
|
- Procedure: Focused ultrasound (MRgFUS)
- Procedure: Uterine artery embolization (UAE)
|
Interventional |
Phase 4 |
- Mayo Clinic
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Symptomatic outcomes measured by validated instruments
- Adverse events following treatment
- Biologic predictors of outcome
|
56 |
Female |
25 Years and older (Adult, Senior) |
NCT00995878 |
09-005095
1RC1HD063312-01 |
|
April 29, 2010 |
December 2016 |
December 2017 |
October 15, 2009 |
January 12, 2018 |
|
- University of California, San Francisco
San Francisco, California, United States - Mayo Clinic
Rochester, Minnesota, United States - Duke University Health System
Durham, North Carolina, United States
|
| 16 |
NCT01802281 |
Active, not recruiting |
Study of Uterine Prolapse Procedures - Randomized Trial |
|
- Procedure: Uterosacral ligament suspension
- Procedure: Uphold® LITE
|
Interventional |
Not Applicable |
- NICHD Pelvic Floor Disorders Network
- Boston Scientific Corporation
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Time to treatment failure. Treatment failure is defined as any one of: Report of bothersome vaginal bulge symptoms (definition below), Re-treatment for prolapse (surgery or pessary), or Any prolapse measure (Ba, C, Bp) is beyond the hymen (i.e. >0cm)
- Efficacy Outcomes
- Safety
- (and 3 more...)
|
180 |
Female |
21 Years and older (Adult, Senior) |
NCT01802281 |
PFDN-24P01 |
SUPeR |
April 2013 |
April 2018 |
April 2018 |
March 1, 2013 |
August 24, 2016 |
|
- University of Alabama at Birmingham, Department of Obstetrics and Gynecology
Birmingham, Alabama, United States - University of California at San Diego, UCSD Women's Pelvic Medicine Center
La Jolla, California, United States - University of New Mexico Health Sciences Center, Department of Obstetrics and Gynecology
Albuquerque, New Mexico, United States - (and 5 more...)
|
| 17 |
NCT00017719 |
Completed |
Combination Treatment With and Without Protease Inhibitors for Women Who Begin Therapy for HIV Infection During Pregnancy |
|
- Drug: Lamivudine
- Drug: Lamivudine/Zidovudine
- Drug: Nelfinavir mesylate
- (and 2 more...)
|
Interventional |
Phase 3 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of women in each treatment group who continue on original therapy with virologic suppression to less than 500 copies/ml at 34 weeks gestation (or the last viral load determination prior to delivery)
- proportion of women in each treatment group who continue on original therapy with virologic suppression to less than 500 copies/ml at 48 weeks postpartum
- Proportion of women in each treatment group who continue on original therapy with virologic suppression to less than 50 copies/ml at 34 weeks gestation (or the last viral load determination prior to delivery)
- (and 10 more...)
|
440 |
Female |
14 Years and older (Child, Adult, Senior) |
NCT00017719 |
P1022
10192
ACTG P1022
PACTG P1022 |
|
May 2002 |
|
March 2006 |
August 31, 2001 |
November 26, 2013 |
|
- Usc La Nichd Crs
Los Angeles, California, United States - UCSD Mother-Child-Adolescent Program CRS
San Diego, California, United States - UCSF Pediatric AIDS CRS
San Francisco, California, United States - (and 46 more...)
|
| 18 |
NCT00125177 |
Completed |
IRIS: Incontinence Research Intervention Study |
- Urinary Incontinence
- Urinary Incontinence, Stress
|
- Behavioral: Knack therapy
|
Interventional |
Phase 1
Phase 2 |
- University of Michigan
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The short-term outcome of "positive response" is defined as able to reduce leakage during coughing to under 2 ml or 50% decrease from baseline (whichever is more stringent). This will be evaluated immediately at 1 month.
- Long-term success (3-months and 1-year) is defined both by the paper towel test criteria and by documentation of at least 50% reduction of leakage in diary to reflect success at home.
|
320 |
Female |
18 Years and older (Adult, Senior) |
NCT00125177 |
P50HD044406
1P50HD044406
IRBMED# 2002-0635 |
|
January 2003 |
|
April 2008 |
July 29, 2005 |
November 10, 2010 |
|
- University of Michigan, School of Nursing
Ann Arbor, Michigan, United States
|
| 19 |
NCT02163434 |
Recruiting |
Comparison of Gabapentin and Metoclopramide for Treating Hyperemesis Gravidarum |
|
- Drug: Gabapentin
- Drug: Metoclopramide
|
Interventional |
Phase 3 |
- University at Buffalo
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Mean percent change from Baseline to the Study Endpoint in daily Motherisk-PUQE scores (pregnancy-unique quantification of emesis and nausea scale).
- Mean percent change from Baseline to the Study Endpoint in daily nausea and emesis/retching scores individually from the Motherisk-PUQE and from the raw data.
- Mean percent change from Baseline to the Study Endpoint in daily oral nutrition scores.
- (and 11 more...)
|
80 |
Female |
18 Years and older (Adult, Senior) |
NCT02163434 |
496486-3
1R01HD076313-01A1 |
|
June 2014 |
September 2017 |
May 2018 |
June 13, 2014 |
August 4, 2015 |
|
- University at Buffalo
Buffalo, New York, United States - University of Rochester
Rochester, New York, United States
|
| 20 |
NCT00151411 |
Completed
Has Results |
Lifestyle Intervention and Metformin for Women With Polycystic Ovary Syndrome (PCOS) |
- Polycystic Ovary Syndrome
|
- Drug: Metformin
- Drug: Placebo
- Behavioral: Lifestyle Intervention
|
Interventional |
Phase 2 |
- Milton S. Hershey Medical Center
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in Testosterone After 6 Months of Treatment
- Ovulation Rate
- Change in Insulin Sensitivity Index After 6 Months of Treatment
|
114 |
Female |
12 Years to 39 Years (Child, Adult) |
NCT00151411 |
2003-172
HD-02-012 |
|
October 2004 |
March 2008 |
March 2008 |
September 9, 2005 |
March 21, 2018 |
November 8, 2011 |
- Penn State Milton S. Hershey Medical Center
Hershey, Pennsylvania, United States
|
| 21 |
NCT00827632 |
Completed
Has Results |
Obesity, Oral Contraception, and Ovarian Suppression |
|
- Drug: Low dose formulation
- Drug: High dose formulation
|
Interventional |
Phase 4 |
- Columbia University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Risk of Oral Contraceptive (OC) Failure Due to Less Contraceptive-mediated Ovarian Suppression.
- Possible Changes in Lipid or Carbohydrate Metabolism in Obese Versus Normal Weight Oral Contraceptive (OC) Users.
- Pharmacokinetics of 15 Obese Weight and 15 Normal Weight Women on Combined Oral Contraceptives.
|
226 |
Female |
18 Years to 35 Years (Adult) |
NCT00827632 |
AAAB4823
R01HD045786 |
20/30 |
July 2006 |
December 2008 |
December 2008 |
January 23, 2009 |
December 13, 2012 |
June 14, 2011 |
- Columbia University Medical Center
New York, New York, United States
|
| 22 |
NCT00084045 |
Completed |
Voluntary HIV Counseling, Testing, and Medication for Pregnant Women to Prevent Mother-to-Child HIV Transmission |
|
- Procedure: Intrapartum HIV counseling/testing
- Procedure: Postpartum HIV counseling/testing
|
Interventional |
Not Applicable |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Time required to obtain informed consent
- time from initiation of HIV pre-test counseling until test results are available
- proportion of test evaluations completed before delivery
- (and 13 more...)
|
283 |
Female |
14 Years and older (Child, Adult, Senior) |
NCT00084045 |
PACTG P1031A
MIRIAD |
|
November 2004 |
|
December 2006 |
June 7, 2004 |
October 30, 2012 |
|
- Hottentots Holland Hospital
Cape Town, South Africa - Maccassar Community Health Clinic
Cape Town, South Africa
|
| 23 |
NCT02160938 |
Recruiting |
Prenatal Microarray Follow-Up Study |
|
|
Observational |
|
- Columbia University
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Human Genome Research Institute (NHGRI)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Full Scale Intelligence Quotient (IQ) score
- Percent of subjects with specific commonly occurring CNVs
- Percent of subjects with seizure disorders
- (and 14 more...)
|
390 |
All |
18 Years and older (Adult, Senior) |
NCT02160938 |
AAAL0100
5U01HD055651 |
|
February 2013 |
March 2018 |
March 2018 |
June 11, 2014 |
July 24, 2017 |
|
- Center for Fetal Medicine
Los Angeles, California, United States - George Washington University Biostatistics Center
Rockville, Maryland, United States - Montefiore Medical Center
Larchmont, New York, United States - (and 6 more...)
|
| 24 |
NCT00467363 |
Completed
Has Results |
The Effects of Aspirin in Gestation and Reproduction |
- Birth
- Spontaneous Abortion
|
- Drug: acetylsalicylic-acid (aspirin)
- Dietary Supplement: Folic acid
|
Interventional |
Not Applicable |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Live Birth
- hCG Recognized Pregnancy
- Clinically Recognized Pregnancy
- (and 12 more...)
|
1228 |
Female |
18 Years to 40 Years (Adult) |
NCT00467363 |
EAGeR |
EAGeR |
June 2007 |
July 2012 |
July 2012 |
April 30, 2007 |
February 3, 2017 |
May 14, 2014 |
- University of Colorado, Denver School of Medicine, Department of Obstetrics and Gynecology
Denver, Colorado, United States - Women's Health Research Center, Department of Social and Preventive Medicine, University at Buffalo
Buffalo, New York, United States - Moses Taylor Hospital
Scranton, Pennsylvania, United States - University of Utah Medical Center
Salt Lake City, Utah, United States
|
| 25 |
NCT00540605 |
Completed |
Blood Levels of Tenofovir Gel in HIV Uninfected Pregnant Women Planning Cesarean Delivery |
|
- Drug: Tenofovir 1% vaginal gel
|
Interventional |
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Microbicide Trials Network
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
NIH / Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
|
- Maternal third trimester pharmacokinetic (PK) measures (AUC and Cmax)
- Endometrial tenofovir levels
- Placental transfer (cord blood tenofovir levels, placental tissue tenofovir levels, and amniotic fluid tenofovir levels)
|
21 |
Female |
18 Years to 45 Years (Adult) |
NCT00540605 |
MTN-002
10600
1-U01-AI068633-0 |
|
|
|
January 2010 |
October 8, 2007 |
May 18, 2012 |
|
- Pitt CRS
Pittsburgh, Pennsylvania, United States
|
| 26 |
NCT00076791 |
Completed |
Safety of Tenofovir Disoproxil Fumarate (TDF) and Emtricitabine/TDF in HIV Infected Pregnant Women and Their Infants |
|
- Drug: Emtricitabine/Tenofovir disoproxil fumarate
- Drug: Tenofovir disoproxil fumarate
|
Interventional |
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
|
NIH / Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Adverse experiences with a severity of Grade 3 or 4 and adverse pregnancy outcomes that cannot be directly attributed to a cause besides study treatment
- Maternal viral load
- viral resistance to emtricitabine/tenofovir disoproxil fumarate using bulk sequencing
- infant HIV DNA PCR
|
66 |
Female |
18 Years and older (Adult, Senior) |
NCT00076791 |
P394
10034
PACTG 394
IMPAACT 394 |
|
March 2004 |
March 2010 |
March 2011 |
February 6, 2004 |
July 9, 2013 |
|
- Children's National Med. Ctr. Washington DC NICHD CRS
Washington, District of Columbia, United States - Washington Hosp. Ctr. NICHD CRS
Washington, District of Columbia, United States - Univ. of Miami Ped. Perinatal HIV/AIDS CRS
Miami, Florida, United States - (and 9 more...)
|
| 27 |
NCT00028145 |
Completed |
Prenatal and Postnatal Studies of Interventions for Prevention of Mother-To-Child Transmission |
- HIV Infections
- Pregnancy Complications, Infectious
|
- Behavioral: Adherence assessment
|
Observational |
|
- International Maternal Pediatric Adolescent AIDS Clinical Trials Group
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Maternal and infant response to prescribed interventions
- Immune and viral parameters of participants taking prescribed interventions
- Occurrences of genotypic and phenotypic resistance in HIV-infected mothers
- (and 3 more...)
|
3090 |
Female |
14 Years and older (Child, Adult, Senior) |
NCT00028145 |
PACTG P1025
U01AI068632 |
|
October 2002 |
June 2013 |
June 2013 |
December 14, 2001 |
October 10, 2014 |
|
- Univ. of Alabama Birmingham NICHD CRS (5096)
Birmingham, Alabama, United States - University of South Alabama
Mobile, Alabama, United States - Phoenix Childrens Hospital
Phoenix, Arizona, United States - (and 74 more...)
|
| 28 |
NCT01468935 |
Completed |
Bone Marrow Cell Engraftment of the Uterus and Genetic Studies of Reproductive Functioning |
- Endometriosis
- Stem Cell Transplant
- Healthy Volunteers
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To study if endometiral stem cells are different in normal and disease states.
- To study if the type of hematopoietic transplantation regimen affects uterine engraftment of donor stem cells.
|
79 |
Female |
18 Years and older (Adult, Senior) |
NCT01468935 |
120016
12-CH-0016 |
|
October 31, 2011 |
|
September 21, 2017 |
November 10, 2011 |
April 19, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 29 |
NCT01959347 |
Active, not recruiting |
Combined Treatment for Mixed Incontinence |
- Urinary Incontinence, Stress
- Urinary Incontinence, Urge
|
- Procedure: Miduretheral Sling
- Other: Miduretheral Sling with behavioral/pelvic floor therapy
|
Interventional |
Phase 3 |
- NICHD Pelvic Floor Disorders Network
- Women and Infants Hospital of Rhode Island
- The Cleveland Clinic
- (and 9 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Treatment
|
- Severity of MUI symptoms
- OAB symptom outcomes
- SUI symptom outcomes
|
480 |
Female |
21 Years and older (Adult, Senior) |
NCT01959347 |
PFDN-26P01
U10HD041261
U10HD069013
U10HD054215
U10HD041267
U10HD054214
U10HD069025
U10HD069010
U10HD041263
U01HD069031 |
ESTEEM |
October 2013 |
October 2017 |
October 2017 |
October 10, 2013 |
February 10, 2017 |
|
- University of Alabama at Birmingham, Department of Obstetrics and Gynecology
Birmingham, Alabama, United States - Kaiser Permanente -- Downey
Downey, California, United States - University of California at San Diego, UCSD Women's Pelvic Medicine Center
La Jolla, California, United States - (and 7 more...)
|
| 30 |
NCT01502956 |
Completed
Has Results |
Refractory Overactive Bladder: Sacral NEuromodulation v. BoTulinum Toxin Assessment (ROSETTA) |
- Urinary Incontinence, Urge
|
- Device: InterStim® device
- Drug: Botox® injection
|
Interventional |
Phase 3 |
- NICHD Pelvic Floor Disorders Network
- Duke University
- University of Alabama at Birmingham
- (and 9 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Urge Urinary Incontinence (UUI) Episodes
- Number of Participants With Improvement of Bladder Function and Urinary Leakage
- Change in Overactive Bladder
- (and 7 more...)
|
386 |
Female |
21 Years and older (Adult, Senior) |
NCT01502956 |
PFDN 20
U01HD069031 |
ROSETTA |
February 2012 |
July 2016 |
July 2016 |
January 2, 2012 |
March 8, 2018 |
March 8, 2018 |
- University of Alabama at Birmingham, Department of Obstetrics and Gynecology
Birmingham, Alabama, United States - University of California, San Diego, Women's Pelvic Medicine Center
La Jolla, California, United States - University of New Mexico Health Sciences Center
Albuquerque, New Mexico, United States - (and 6 more...)
|
| 31 |
NCT00098163 |
Completed |
Safety of and Immune Response to an HIV-1 Vaccine (ALVAC-HIV vCP1521) in Infants Born to HIV Infected Mothers |
|
- Biological: ALVAC-HIV vCP1521
- Biological: ALVAC HIV-1 vCP1521
|
Interventional |
Phase 1 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute on Drug Abuse (NIDA)
- National Institute of Mental Health (NIMH)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Grade 3 or higher adverse events attributable to the vaccine. Mild and moderate adverse event rates will also be tabulated
- Cell-mediated immunologic response as measured by HIV-specific cytotoxic T-lymphocyte activity against viral antigens
- Humoral immunologic response as measured by detection of binding antibody to vaccine antigens and by neutralizing antibody assay
- (and 2 more...)
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT00098163 |
HPTN 027
10141 |
|
|
|
May 2009 |
December 6, 2004 |
May 4, 2012 |
|
- Makerere University- JHU Research Collaboration {MUJHU CARE LTD} CRS
Kampala, Uganda
|
| 32 |
NCT00615550 |
Completed
Has Results |
PREGNANT Short Cervix Trial |
- Preterm Delivery
- Short Cervix
- Short Uterine Cervical Length
|
- Drug: progesterone
- Drug: placebo
|
Interventional |
Phase 3 |
- Juniper Pharmaceuticals, Inc.
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Number of Participants With Birth <=32 6/7 Weeks Gestation.
- Number of Infants With Neonatal Morbidities Such as Respiratory Distress Syndrome (RDS), Bronchopulmonary Dysplasia (BPD), Intraventricular Hemorrhage (IVH), Proven Sepsis, and Necrotizing Enterocolitis (NEC)
- Number of Subjects With Preterm Birth at ≤27 6/7, ≤34 6/7, and <36 6/7 Weeks Gestation.
- (and 2 more...)
|
465 |
Female |
15 Years to 45 Years (Child, Adult) |
NCT00615550 |
COL-1620-302
09-CH-N014 |
|
March 2008 |
November 2010 |
November 2010 |
February 14, 2008 |
March 13, 2012 |
March 13, 2012 |
- University of South Alabama Dept. of OB/GYN
Mobile, Alabama, United States - St. Joseph's Hospital and Med Ctr Women's Care Center
Phoenix, Arizona, United States - UCI Medical Center
Orange, California, United States - (and 46 more...)
|
| 33 |
NCT01322529 |
Completed |
Nulliparous Pregnancy Outcomes Study: Monitoring Mothers-to-be |
- Pregnancy
- Pregnancy Complications
|
|
Observational |
|
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Heart, Lung, and Blood Institute (NHLBI)
- Office of Research on Women's Health (ORWH)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Adverse pregnancy outcome
- Preterm birth
- Spontaneous preterm birth
- (and 2 more...)
|
10038 |
Female |
13 Years and older (Child, Adult, Senior) |
NCT01322529 |
NICHD-nuMoM2b-001
1U10HD063036-01
1U10HD063072-01
1U10HD063047-01
1U10HD063037-01
1U10HD063041-01
1U10HD063020-01
1U10HD063046-01
1U10HD063048-01
1U10HD063053-01 |
nuMoM2b |
September 2010 |
May 2015 |
May 2015 |
March 24, 2011 |
January 12, 2016 |
|
- Fountain Valley Regional Hospital and Medical Center- UCI MFM private practice
Fountain Valley, California, United States - Long Beach Memorial Medical Center, Women's and Children's Hospital - Women's Perinatal Group, OB Clinic
Long Beach, California, United States - University of California, Irvine, Medical Center - Prenatal care clinics and private practice
Orange, California, United States - (and 14 more...)
|
| 34 |
NCT02070718 |
Completed |
Effects of a Kappa Agonist on Hot Flashes in Menopausal Women |
- Treatment of Menopausal Hot Flashes
|
- Drug: Standard Dose Kappa Agonist
- Drug: Half Dose Kappa Agonist
- Other: Placebo
|
Interventional |
Phase 1 |
- University of Washington
- National Institute on Aging (NIA)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- (and 3 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hot Flashes
- Subjectively measured hot flashes
- Change in Serum Leutinizing Hormone
|
12 |
Female |
45 Years to 60 Years (Adult) |
NCT02070718 |
43952-B
GYN-01-2012 |
|
January 2013 |
July 2013 |
July 2013 |
February 25, 2014 |
July 1, 2015 |
|
- University of Washington
Seattle, Washington, United States
|
| 35 |
NCT00111943 |
Completed |
Safety and Acceptability of a Vaginal Microbicide |
- HIV Infections
- Hepatitis B, Chronic
|
|
Interventional |
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute on Drug Abuse (NIDA)
- National Institute of Mental Health (NIMH)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Prevention
|
- Macroscopic evidence of damage to the cervical, vulvar, or vaginal epithelium, including ulceration and other lesions, severe erythema, or severe edema, related or not related to the study gel or applicator
- Adherence to the study gel regimen
- acceptability of the study gel
|
200 |
Female |
18 Years to 50 Years (Adult) |
NCT00111943 |
HPTN 059
10145 |
|
|
|
October 2007 |
May 27, 2005 |
March 27, 2012 |
|
- Alabama Microbicide CRS
Birmingham, Alabama, United States - Bronx- Lebanon Hospital Center Clinical Research Site (BLHC CRS)
Bronx, New York, United States - NARI Arogya Aadhar Clinic CRS
Pune, Maharashtra, India
|
| 36 |
NCT00263341 |
Completed |
Safety and Efficacy of a Contraceptive Vaginal Ring Delivering Nestorone® and Ethinyl Estradiol |
|
- Combination Product: NES/EE CVR
|
Interventional |
Phase 3 |
- Population Council
- United States Agency for International Development (USAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- World Health Organization
|
Other / U.S. Fed / NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
|
1135 |
Female |
18 Years to 40 Years (Adult) |
NCT00263341 |
Protocol 300 |
|
December 2005 |
August 2014 |
August 2014 |
December 8, 2005 |
October 6, 2017 |
|
- Women and Children's Hospital, LAC/USC Medical Center
Los Angeles, California, United States - University of California, San Francisco General Hospital, Department of Obstetrics & Gynecology
San Francisco, California, United States - University of Chicago Hospitals
Chicago, Illinois, United States - (and 9 more...)
|
| 37 |
NCT00074412 |
Completed
Has Results |
Using Nevirapine to Prevent Mother-to-Child HIV Transmission During Breastfeeding |
|
- Drug: Nevirapine
- Drug: Nevirapine placebo
|
Interventional |
Phase 3 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute on Drug Abuse (NIDA)
- National Institute of Mental Health (NIMH)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Prevention
|
- HIV Infection in Infants Determined to be HIV Uninfected at 6 Weeks Enrolled in Each Arm of the Study
- Frequency and Severity of Adverse Reactions Among Participating Infants
- Proportion of Infants Who Are Alive and HIV-uninfected in the Two Arms
- (and 7 more...)
|
2026 |
All |
Child, Adult, Senior |
NCT00074412 |
HPTN 046
10142 |
|
January 2007 |
September 2011 |
November 2011 |
December 15, 2003 |
September 16, 2013 |
September 16, 2013 |
- CAPRISA Umlazi CRS
Umlazi, KwaZulu-Natal, South Africa - Muhimbili University of Health and Allied Sciences (MUHAS) CRS
Dar es Salaam, Tanzania - Makerere University- JHU Research Collaboration {MUJHU CARE LTD} CRS
Kampala, Mpigi, Uganda - (and 2 more...)
|
| 38 |
NCT00074425 |
Completed |
BufferGel and PRO 2000/5: Vaginal Gels to Prevent HIV Infection in Women |
|
- Drug: BufferGel
- Drug: PRO 2000/5 Gel
- Drug: Placebo gel
|
Interventional |
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institute on Drug Abuse (NIDA)
- (and 2 more...)
|
NIH / Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Safety of BufferGel and 0.5% PRO 2000/5 Gel (P), as assessed by deep epithelial disruption, other genital symptoms, or other systemic symptoms
- HIV infection as measured by seroconversion
- Bacterial vaginosis
- (and 11 more...)
|
3101 |
Female |
18 Years and older (Adult, Senior) |
NCT00074425 |
HPTN 035
10065 |
|
January 2005 |
September 2008 |
September 2008 |
December 15, 2003 |
July 11, 2013 |
|
- 3535 Market Street CRS
Philadelphia, Pennsylvania, United States - University of North Carolina Lilongwe CRS
Lilongwe, Central, Malawi - College of Med. JHU CRS
Blantyre, Southern, Malawi - (and 5 more...)
|
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