| 1 |
NCT02180243 |
Recruiting |
CAM in Veterans With Gulf War Illnesses |
- Gulf War Veterans' Illness
|
- Behavioral: Yoga/Acupuncture
- Other: Gulf War Health Education
|
Interventional
|
Phase 1
Phase 2 |
- VA Office of Research and Development
- Georgetown University
- MedStar Hospitals
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
|
172 |
All |
18 Years and older (Adult, Older Adult) |
NCT02180243 |
SPLD-013-13S
CX000801-01A2 |
GW-CAM |
May 12, 2016 |
September 30, 2019 |
September 1, 2020 |
July 2, 2014 |
September 27, 2018 |
|
- Washington DC VA Medical Center, Washington, DC
Washington, District of Columbia, United States
|
|
| 2 |
NCT01264471 |
Completed |
Mechanisms of Mitochondrial Defects in Gulf War Syndrome |
- Gulf War Syndrome
- Mitochondrial Disease
|
- Procedure: Skin biopsy
- Procedure: Blood Collection
|
Observational
|
|
- Medical Neurogenetics, LLC
- United States Department of Defense
|
Other / U.S. Fed |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Characterize mitochondrial cellular energetics in Gulf War Syndrome patients
- Mitochondrial DNA
|
26 |
All |
18 Years and older (Adult, Older Adult) |
NCT01264471 |
H09378
GW080138 |
|
May 2009 |
June 2013 |
June 2013 |
December 21, 2010 |
April 13, 2015 |
|
- Medical Neurogenetics, LLC
Atlanta, Georgia, United States
|
|
| 3 |
NCT02909686 |
Active, not recruiting |
Effects of Botanical Microglia Modulators in Gulf War Illness |
|
- Dietary Supplement: Boswellia Serrata
- Dietary Supplement: Curcumin
- Dietary Supplement: Epimedium
- (and 7 more...)
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Congressionally Directed Medical Research Programs
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Change from baseline in overall Gulf War Illness disease severity
- Change from baseline in Pain Severity
- Change from baseline in Fatigue Severity
- (and 5 more...)
|
64 |
Male |
39 Years to 65 Years (Adult, Older Adult) |
NCT02909686 |
F150318011
CDMRP-GW130015 |
|
July 2016 |
September 2019 |
September 2019 |
September 21, 2016 |
August 7, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States
|
|
| 4 |
NCT01703767 |
Withdrawn |
Gulf War 1 Veteran Healthcare Satisfaction |
- Persian Gulf War Syndrome in Veteran
|
- Behavioral: Provider Education Workshop
|
Observational
|
|
- University of Utah
- VA Salt Lake City Health Care System
|
Other / U.S. Fed |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Change in Client Satisfaction score
- Change in Patient Satisfaction score
- Change in Physician Assessment of GW1V Care
|
0 |
All |
38 Years to 80 Years (Adult, Older Adult) |
NCT01703767 |
IRB_00053707 |
|
October 2014 |
July 2015 |
October 2015 |
October 10, 2012 |
August 11, 2016 |
|
- University of Utah
Salt Lake City, Utah, United States - VA SLC Health Care System
Salt Lake City, Utah, United States
|
|
| 5 |
NCT02206490 |
Completed |
Trial of Naltrexone and Dextromethorphan for Gulf War Illness |
|
- Drug: naltrexone
- Drug: Dextromethorphan
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Symptoms Scores
- SF-36
- Connors Continuous Performance Test
|
60 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT02206490 |
090562 |
GWI Treatment |
January 2012 |
January 2016 |
January 2016 |
August 1, 2014 |
March 3, 2016 |
|
- Brody School of Medicine a East Carolina Univesity
Greenville, North Carolina, United States
|
|
| 6 |
NCT02011542 |
Terminated
Has Results |
Probiotic (VSL #3) for Gulf War Illness |
|
|
Interventional
|
Phase 2
Phase 3 |
- University of Utah
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement in the Bowel Symptom Scale (BSS) From Baseline
- Change in Chronic Fatigue (1-5 Scale) From Baseline
|
29 |
All |
35 Years to 75 Years (Adult, Older Adult) |
NCT02011542 |
W81XWH-10-1-0593 |
|
September 2013 |
July 2016 |
July 2016 |
December 13, 2013 |
October 26, 2018 |
January 16, 2018 |
- George E Wahlen VA Medical Center
Salt Lake City, Utah, United States
|
|
| 7 |
NCT02161133 |
Active, not recruiting |
Cognitive Rehabilitation for Gulf War Illness |
|
- Behavioral: Problem-Solving Therapy
- Behavioral: Health Education
|
Interventional
|
Phase 3 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Disability - WHO-DAS 2
- Problem-Solving Inventory
- Problem-Solving Ability
- (and 2 more...)
|
300 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02161133 |
SPLD-009-13S |
|
January 1, 2015 |
December 31, 2018 |
September 1, 2019 |
June 11, 2014 |
January 15, 2019 |
|
- Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA
Bedford, Massachusetts, United States - East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
East Orange, New Jersey, United States - Canandaigua VA Medical Center, Canandaigua, NY
Canandaigua, New York, United States
|
|
| 8 |
NCT03547869 |
Recruiting |
Transcranial Direct Current Stimulation for Pain Treatment in Gulf War Illness. |
|
- Device: Active tDCS
- Device: Sham tDCS
|
Interventional
|
Not Applicable |
- The University of Texas at Dallas
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Pain symptom changes will be measured by a Visual Analogue Scale for pain .
- Electroencephalography (EEG) recordings will be used to asses changes in brain activity.
|
120 |
All |
45 Years to 78 Years (Adult, Older Adult) |
NCT03547869 |
17-88 |
|
March 12, 2018 |
March 12, 2021 |
March 12, 2021 |
June 6, 2018 |
June 6, 2018 |
|
- University of Texas at Dallas
Richardson, Texas, United States
|
|
| 9 |
NCT01803854 |
Active, not recruiting |
Gulf War Era Cohort and Biorepository |
|
|
Observational
|
|
- VA Office of Research and Development
|
U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The topics that will be measured by the survey are military service, lifestyle behaviors, physical and mental health, and family (including family health).
|
1275 |
All |
Child, Adult, Older Adult |
NCT01803854 |
585
11-09 |
CSP# 585 |
September 2, 2014 |
July 21, 2019 |
July 21, 2021 |
March 4, 2013 |
January 9, 2019 |
|
- Durham VA Medical Center, Durham, NC
Durham, North Carolina, United States
|
|
| 10 |
NCT01011348 |
Unknown † |
Q10 for Gulf War Veterans |
|
- Dietary Supplement: Coenzyme Q10
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
- University of California, San Diego
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Coenzyme Q10 will improve overall subjective quality of life in ill Gulf War Veterans, using a single item General Self-Rated Health measure.
- Coenzyme Q10 will improve specific symptoms that dominate definitions of illness in GWV including fatigue, pain, and muscle strength.
- Coenzyme Q10 will subjectively improve other symptoms reported to arise at elevated rates in GWV defined by responses on a symptom survey (e.g. headache, shortness of breath, sleep problems, gastrointestinal problems).
- (and 2 more...)
|
46 |
All |
18 Years and older (Adult, Older Adult) |
NCT01011348 |
W81WH-07-1-0667 |
GULF |
July 2008 |
September 2010 |
|
November 11, 2009 |
October 27, 2016 |
|
- University of California, San Diego
La Jolla, California, United States
|
|
| 11 |
NCT03082638 |
Recruiting |
Identification of Gulf War Illness (GWI) Biomarkers |
|
|
Observational
|
|
- Roskamp Institute Inc.
- United States Department of Defense
|
Other / U.S. Fed |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Lipid bio markers
- Identification of Subgroups
|
100 |
All |
35 Years and older (Adult, Older Adult) |
NCT03082638 |
RI-GWI-001 |
|
January 18, 2017 |
December 2019 |
December 2019 |
March 17, 2017 |
April 12, 2018 |
|
- The Roskamp Institute, Inc.
Sarasota, Florida, United States
|
|
| 12 |
NCT02915237 |
Active, not recruiting |
Development of a Polyphenol-rich Dietary Preparation for Treating Veterans With Gulf War Illness |
|
- Dietary Supplement: Concord grape juice
- Dietary Supplement: Placebo Beverage
|
Interventional
|
Phase 1
Phase 2 |
- Icahn School of Medicine at Mount Sinai
- United States Department of Defense
- Department of Veterans Affairs, New Jersey
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Brief Symptom Inventory (BSI)
- Patient Health Questionnaire-15 (PHQ-15)
- California Verbal Learning Test-Second Edition (CVLT-II)
- (and 9 more...)
|
36 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02915237 |
GCO 13-1398 |
|
August 2016 |
January 31, 2019 |
January 31, 2019 |
September 26, 2016 |
November 15, 2018 |
|
- VA- New Jersey Health Care System
East Orange, New Jersey, United States
|
|
| 13 |
NCT02983734 |
Recruiting |
D-cycloserine: A Novel Treatment for Gulf War Illness (GWDCS) |
|
- Drug: D-cycloserine
- Drug: Placebos
|
Interventional
|
Phase 2 |
- Boston University Charles River Campus
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Neuropsychological Test Battery
- Symptom Questionnaires
|
56 |
All |
43 Years to 85 Years (Adult, Older Adult) |
NCT02983734 |
W81XWH-15-1-0588 |
GWDCS |
October 2015 |
September 2019 |
September 2019 |
December 6, 2016 |
January 15, 2019 |
|
- Boston University
Boston, Massachusetts, United States
|
|
| 14 |
NCT02782780 |
Recruiting |
Cognitive Behavioral Therapy for Insomnia for Gulf War Illness |
|
- Behavioral: Cognitive Behavioral Therapy for Insomnia (CBTi)
|
Interventional
|
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Insomnia Severity Index (ISI)
- Pittsburgh Sleep Quality Index (PSQI)
- Gulf War Illness Symptoms
- (and 7 more...)
|
80 |
All |
Child, Adult, Older Adult |
NCT02782780 |
SPLD-12-15F
I21CX001428 |
CBTi GWI |
October 24, 2016 |
January 31, 2020 |
May 30, 2020 |
May 25, 2016 |
January 25, 2019 |
|
- San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States
|
|
| 15 |
NCT03078530 |
Recruiting |
Probiotic (Visbiome) for Gulf War Illness |
|
- Drug: Placebo
- Drug: Visbiome
- Drug: VSL#3
|
Interventional
|
Phase 2
Phase 3 |
- Ashok Tuteja
- United States Department of Defense
- VA Salt Lake City Health Care System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in the bowel symptom scale from the baseline
- Change in chronic fatigue (1-5 scale) from baseline
|
60 |
All |
35 Years to 75 Years (Adult, Older Adult) |
NCT03078530 |
IRB_00059006 |
|
September 13, 2013 |
May 31, 2018 |
May 31, 2018 |
March 13, 2017 |
December 13, 2017 |
|
- George E Wahlen VA Medical Center
Salt Lake City, Utah, United States
|
|
| 16 |
NCT02357030 |
Unknown † |
Methylphenidate Plus GWI-Nutrient Formula as a Treatment for Patients With Gulf War Illness |
|
- Drug: Methyl-P plus GWI Nutrient Formula
|
Interventional
|
Phase 2 |
- K-PAX Pharmaceuticals, Inc.
- VA Palo Alto Health Care System
|
Industry / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in patient reported Checklist Individual Strength (CIS) total score
- Percentage of patients with 20% or greater improvement in the CIS total score
- Concentration Disturbances Subscore on the CIS
- (and 7 more...)
|
30 |
All |
18 Years to 64 Years (Adult) |
NCT02357030 |
K-PAX-002-2
CDMRP- GW130047 |
|
January 2015 |
May 2016 |
May 2016 |
February 6, 2015 |
October 15, 2015 |
|
- Veterans Administration Palo Alto Health Care System (VAPAHCS)
Palo Alto, California, United States
|
|
| 17 |
NCT01846182 |
Recruiting |
Research Examining Gulf War Illness in Our Nations Service Members |
|
- Drug: Duloxetine
- Drug: Pregabalin
- Drug: Placebo
|
Interventional
|
Phase 2 |
- VA Office of Research and Development
- Texas A&M University
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pain , Safety, tolerability
- Side Effects
|
162 |
All |
44 Years to 70 Years (Adult, Older Adult) |
NCT01846182 |
SPLD-016-12F
6125 |
REGIONS |
June 24, 2015 |
December 31, 2019 |
January 1, 2021 |
May 3, 2013 |
January 16, 2019 |
|
- Central Texas Veterans Health Care System, Temple, TX
Temple, Texas, United States - Central Texas Veterans Health Care System Waco VA Medical Center, Waco, TX
Waco, Texas, United States
|
|
| 18 |
NCT00810225 |
Completed |
Study of Gulf War Illness (GWI) by Comparing GWI and Healthy Veterans |
- Gulf War Illness
- Persian Gulf War Syndrome
|
|
Observational
|
|
- Georgetown University
- U.S. Army Medical Research and Materiel Command
|
Other / U.S. Fed |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
|
516 |
All |
Child, Adult, Older Adult |
NCT00810225 |
2008-012
USAMRMC PR# W81XWH-07-1-0618
HRPO Log No. A-14542.1 |
|
August 2008 |
July 2011 |
July 2011 |
December 18, 2008 |
June 18, 2018 |
|
- Georgetown University
Washington, District of Columbia, United States
|
|
| 19 |
NCT01672710 |
Completed
Has Results |
Gulf War Illness: Evaluation of an Innovative Detoxification Program |
|
- Drug: plain crystalline niacin, exercise, sauna
|
Interventional
|
Phase 2 |
- University at Albany
- United States Department of Defense
- The Sage Colleges
- (and 2 more...)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Short Form-36 for Veterans Quality of Life Physical Component Summary Scores
- Fatigue Severity
- Pain Severity
|
32 |
All |
Child, Adult, Older Adult |
NCT01672710 |
GW093066 |
|
April 2010 |
August 2015 |
December 2015 |
August 27, 2012 |
December 28, 2018 |
December 28, 2018 |
- Severna Park Health and Wellness Center
Annapolis, Maryland, United States
|
|
| 20 |
NCT01802944 |
Recruiting |
Intranasal Insulin: A Novel Treatment for Gulf War Multisymptom Illness |
- Chronic Multisymptom Illness in Gulf War Veterans
|
- Drug: Intranasal Insulin
- Drug: Placebos
|
Interventional
|
Phase 2 |
- Bronx Veterans Medical Research Foundation, Inc
- VA Boston Healthcare System
- Boston University
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Memory Functioning
- Attention Functioning
- Physical Health
- Mood
|
114 |
All |
40 Years to 89 Years (Adult, Older Adult) |
NCT01802944 |
GW110054 |
|
April 2014 |
December 2017 |
December 2017 |
March 4, 2013 |
October 6, 2017 |
|
- VA Boston Healthcare System
Boston, Massachusetts, United States - James J. Peters VA Medical Center
The Bronx, New York, United States
|
|
| 21 |
NCT02378025 |
Completed |
Treating Chronic Pain in Gulf War Illness |
- Chronic Pain
- Gulf War Illness
- Chronic Illness
|
- Behavioral: Yoga Group
- Behavioral: Pain Management Wellness Group
|
Interventional
|
Not Applicable |
- Palo Alto Veterans Institute for Research
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Pain (Brief Pain Inventory - Short Form)
- Quality of Life (SF-36)
- Fatigue (6-Minute Walk Test)
- Changes in Medication
|
75 |
All |
42 Years to 85 Years (Adult, Older Adult) |
NCT02378025 |
BAY0001AGG
W81XWH-14-1-0615 |
|
October 2014 |
March 2018 |
March 2018 |
March 4, 2015 |
April 17, 2018 |
|
- VA Palo Alto Health Care System
Palo Alto, California, United States
|
|
| 22 |
NCT02865460 |
Recruiting |
CoQ10 in Gulf War Illness |
- Gulf War Illness
- Chronic Fatigue
- Ubiquinol
- Coenzyme Q10
|
- Drug: Ubiquinol
- Drug: Placebo
|
Interventional
|
Phase 3 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Veterans Short Form 36-Item Health Survey Physical Component Summary
- Multidimensional Fatigue Inventory (MFI) scores
- GWI Health Symptom Checklist (HSCI)
- (and 13 more...)
|
200 |
All |
35 Years to 70 Years (Adult, Older Adult) |
NCT02865460 |
SPLD-04-15F |
|
July 24, 2017 |
June 30, 2019 |
December 31, 2019 |
August 12, 2016 |
September 28, 2018 |
|
- Miami VA Healthcare System, Miami, FL
Miami, Florida, United States - VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States - Minneapolis VA Health Care System, Minneapolis, MN
Minneapolis, Minnesota, United States - James J. Peters VA Medical Center, Bronx, NY
Bronx, New York, United States
|
|
| 23 |
NCT00100412 |
Completed |
Hyporeactivity and Gulf War Illness |
- Gulf War Syndrome
- Chronic Fatigue Syndrome
- Post-Traumatic Stress Disorder
|
- Drug: Graded dobutamine infusions
- Drug: Graded phenylephrine injections
- Behavioral: Psychosocial challenge involving socioevaluative public speaking
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Primary Purpose: Diagnostic
|
|
|
All |
Child, Adult, Older Adult |
NCT00100412 |
MHBS-001-99S1 |
|
October 1999 |
|
September 2002 |
December 31, 2004 |
January 21, 2009 |
|
- Gulf War Research Center
East Orange, New Jersey, United States
|
|
| 24 |
NCT02293291 |
Unknown † |
Thermal Clinic Treatment in Gulf War Illness |
- Posttraumatic Stress Disorder
|
- Dietary Supplement: Lithium Water
|
Interventional
|
Phase 1
Phase 2 |
- American Society Of Thermalism And Climatology Inc
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of veterans (GWI) with positive response to lithium water therapy
|
100 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02293291 |
GWI-2014 |
TCTGWI |
September 2014 |
February 2016 |
October 2016 |
November 18, 2014 |
June 23, 2015 |
|
- Gaviota Clinic
Newark, New Jersey, United States
|
|
| 25 |
NCT00691067 |
Completed |
A Controlled Trial of Mifepristone in Gulf War Veterans With Chronic Multisymptom Illness |
- Chronic Multisymptom Illness in Gulf War Veterans
|
- Drug: mifepristone
- Drug: Placebos
|
Interventional
|
Phase 4 |
- Bronx Veterans Medical Research Foundation, Inc
- U.S. Army Medical Research and Materiel Command
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in the health components score of the veterans RAND 36-item health survey (VR-36)
- cognitive functioning and measures of depression, fatigue and PTSD
|
65 |
All |
35 Years and older (Adult, Older Adult) |
NCT00691067 |
GW060048 |
|
May 2008 |
August 2012 |
August 2012 |
June 5, 2008 |
January 31, 2017 |
|
- James J Peters VA Medical Center
Bronx, New York, United States
|
|
| 26 |
NCT00018707 |
Completed |
Follow-up of Psychological and Neurocognitive Gulf War Outcome: Relation to Stress |
|
|
Observational
|
|
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
|
|
|
All |
18 Years and older (Adult, Older Adult) |
NCT00018707 |
MHBS-033-98F |
|
April 1999 |
|
March 2003 |
July 5, 2001 |
January 21, 2009 |
|
- VA, New Orleans
New Orleans, Louisiana, United States
|
|
| 27 |
NCT01543997 |
Completed |
Clinical Benefits of a Novel Sleep-focused Mind-body Program on Gulf War Illness (GWI) Symptoms |
- Sleep Disturbance
- Persian Gulf War Syndrome in Veteran
|
- Behavioral: Mind-Body Bridging Program
- Behavioral: Supportive Education
|
Interventional
|
Phase 2 |
- University of Utah
- VA Salt Lake City Health Care System
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in the measure of the Medical Outcomes Study-Sleep Scale
- Change from baseline in the measure of the Sleep Diary
- Pain
- (and 7 more...)
|
75 |
All |
38 Years to 80 Years (Adult, Older Adult) |
NCT01543997 |
IRB00049003 |
|
January 2012 |
March 2015 |
May 2016 |
March 5, 2012 |
November 18, 2016 |
|
- Pain Research Center
Salt Lake City, Utah, United States - VA SLC Health Care System
Salt Lake City, Utah, United States
|
|
| 28 |
NCT02506192 |
Recruiting |
Gulf War Illness Inflammation Reduction Trial |
- Chronic Inflammation
- Chronic Pain
- Fatigue
- Cognitive Impairment
|
- Drug: Delayed-Release Prednisone
- Drug: Placebo
|
Interventional
|
Phase 3 |
- Minneapolis Veterans Affairs Medical Center
- United States Department of Defense
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline of Veterans Short Form 36-Item Health Survey Physical Component Summary (SF-36V PCS) scores at 8 and 16 weeks
- Change from baseline of McGill Pain Questionnaire-short form (MPQ) scores at 8 and 16 weeks
- Change from baseline of Multidimensional Fatigue Inventory (MFI) scores at 8 and 16 weeks
- (and 3 more...)
|
100 |
All |
Child, Adult, Older Adult |
NCT02506192 |
4554-A |
GWIIRT |
July 2015 |
January 2020 |
January 2020 |
July 23, 2015 |
March 22, 2018 |
|
- Minneapolis Veterans Affairs Medical Center
Minneapolis, Minnesota, United States
|
|
| 29 |
NCT03208049 |
Recruiting |
Predictors of Response to Insomnia Treatments for Gulf War Veterans |
|
- Behavioral: Sleep Restriction Therapy
- Behavioral: Cognitive Therapy
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Insomnia Severity Index
- wake after sleep onset
- SF 36-Item Health Survey 1.0 (SF-36)
- (and 2 more...)
|
100 |
All |
20 Years and older (Adult, Older Adult) |
NCT03208049 |
SDR 15-196
1 I01 HX001839-01A2 |
|
August 1, 2017 |
July 31, 2021 |
July 31, 2021 |
July 5, 2017 |
November 30, 2018 |
|
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
|
| 30 |
NCT01291758 |
Completed |
Exercise in Gulf War Illness (GWI) |
- Gulf War Illness
- Persian Gulf Syndrome
|
|
Observational
|
|
- Georgetown University
- U.S. Army Medical Research and Materiel Command
|
Other / U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- To assess the alterations due to exercise in Gulf War Veterans
|
50 |
All |
38 Years to 86 Years (Adult, Older Adult) |
NCT01291758 |
2009-229
USAMRMC PR# W81XWH-09-1-0526
HRPO Log No. A-15547 |
|
July 2009 |
September 2012 |
September 2012 |
February 8, 2011 |
February 25, 2014 |
|
- Georgetown University
Washington, District of Columbia, United States
|
|
| 31 |
NCT03665740 |
Recruiting |
Multimodal Investigation of the Neuroprotective Effects of Resveratrol (MINER) |
|
|
Interventional
|
Phase 2 |
- VISN 17 Center of Excellence
- Texas A&M University
- Baylor University
- K. R. Love Quantitative Consulting and Collaboration
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from baseline in Cognitive Function
- Change from baseline in Mood
- Change from baseline in Daily Functioning
- (and 2 more...)
|
68 |
All |
44 Years to 68 Years (Adult, Older Adult) |
NCT03665740 |
GW160050 |
MINER |
August 1, 2018 |
August 31, 2022 |
August 31, 2022 |
September 11, 2018 |
September 11, 2018 |
|
- VISN 17 Center of Excellence for Research on Returning War Veterans
Waco, Texas, United States
|
|
| 32 |
NCT00129454 |
Completed |
Telemedicine Treatment for Veterans With Gulf War Illness |
|
- Behavioral: Cognitive Behavioral Therapy
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Primary Purpose: Other
|
- Frequency of medical visitation
- quality of life
|
128 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT00129454 |
GWI 04-355 |
|
September 1, 2005 |
February 22, 2008 |
March 1, 2008 |
August 11, 2005 |
June 6, 2017 |
|
- East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
East Orange, New Jersey, United States
|
|
| 33 |
NCT01700725 |
Unknown † |
Gulf War Illness Nasal Irrigation Study |
- Persian Gulf Syndrome
- Chronic Sinusitis
- Fatigue
- Acute Sinusitis
|
- Other: Nasal Irrigation - Saline
- Drug: Nasal Irrigation - Xylitol
|
Interventional
|
Phase 2 |
- University of Wisconsin, Madison
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Sino-Nasal Outcome Test (SNOT-20) questionnaire
- Multidimensional Fatigue Inventory (MFI)
- Medical Outcomes Survey Short Form-36 (SF-36)
|
48 |
All |
35 Years to 75 Years (Adult, Older Adult) |
NCT01700725 |
GW100054 US Dept of Defense
2011-0843 |
GWINIS |
October 2012 |
June 2016 |
December 2016 |
October 4, 2012 |
May 24, 2016 |
|
- University of Wisconsin General Clinical Research Center
Madison, Wisconsin, United States
|
|
| 34 |
NCT02881944 |
Recruiting |
Effect of Diet on Gulf War Illness |
|
- Behavioral: Low FODMAP Diet
- Behavioral: High FODMAP Diet
|
Interventional
|
Not Applicable |
- Ashok Tuteja
- United States Department of Defense
- VA Salt Lake City Health Care System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in self-reported global Bowel Symptom Score
- Change in self-reported Irritable Bowel Syndrome Quality of Life (IBS-QOL) score
|
68 |
All |
25 Years to 90 Years (Adult, Older Adult) |
NCT02881944 |
IRB_00087668 |
|
August 2016 |
September 2018 |
September 2018 |
August 29, 2016 |
February 1, 2018 |
|
- George E Wahlen VA Medical Center
Salt Lake City, Utah, United States
|
|
| 35 |
NCT02661997 |
Recruiting |
Novel Interventions for GWVI |
- Gulf War Veteran's Illness
|
- Behavioral: Tai Chi Intervention
- Behavioral: Wellness Intervention
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
- Boston University
- Tufts Medical Center
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Brief Pain Inventory - Short Form (BPI)
- Change in Multi-dimensional Fatigue Inventory (MFI-20)
- Change in PROMIS Global Health Scale
- (and 4 more...)
|
120 |
All |
Child, Adult, Older Adult |
NCT02661997 |
SPLD-004-15S |
NIGWVI |
June 1, 2017 |
December 30, 2020 |
March 31, 2021 |
January 25, 2016 |
September 18, 2018 |
|
- VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States
|
|
| 36 |
NCT02804828 |
Not yet recruiting |
Mitochondrial Cocktail for Gulf War Illness |
- Gulf War Syndrome
- Persian Gulf Syndrome
- Mitochondrial Disorders
|
- Dietary Supplement: Individualized mitochondrial cocktail
- Dietary Supplement: Arctic cod liver oil capsules
- Dietary Supplement: Placebo
|
Interventional
|
Not Applicable |
- University of California, San Diego
|
Other |
|
- Change from baseline of predictive biological markers of Gulf War illness (including α-ketoglutarate, fumarate, malate, citrate, and isocitrate) in blood
|
|
All |
43 Years and older (Adult, Older Adult) |
NCT02804828 |
GW140146 |
|
|
September 2019 |
|
June 17, 2016 |
December 20, 2018 |
|
|
|
| 37 |
NCT01267045 |
Completed
Has Results |
Mindfulness-Based Stress Reduction for Gulf War Syndrome |
|
- Behavioral: Mindfulness-based stress reduction
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Short-form McGill Pain Questionnaire
- The Short-Form McGill Pain Questionnaire
- Multidimensional Fatigue Inventory - General Fatigue
- (and 5 more...)
|
55 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01267045 |
SPLD-008-10S |
|
October 2010 |
December 2012 |
April 2014 |
December 24, 2010 |
August 7, 2015 |
December 17, 2014 |
- VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States
|
|
| 38 |
NCT01305811 |
Completed
Has Results |
Acupuncture in the Treatment of Gulf War Illness |
|
|
Interventional
|
Phase 1
Phase 2 |
- New England School of Acupuncture
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
104 |
All |
39 Years and older (Adult, Older Adult) |
NCT01305811 |
GW080059(W81XWH-09-2-0064) |
|
July 2009 |
January 2013 |
January 2013 |
March 1, 2011 |
June 15, 2015 |
May 21, 2015 |
- New England School of Acupuncture
Newton, Massachusetts, United States
|
|
| 39 |
NCT00252629 |
Completed
Has Results |
Sleep Disordered Breathing in Gulf War Illness and the Effect of Nasal CPAP Treatment |
- Apnea, Sleep
- Chronic Fatigue Syndrome
|
- Other: Nasal CPAP treatment during sleep
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change of Fatigue Symptom
- The Prevalence of Inspiratory Flow Limitation (IFL) During Sleep in GWS.
- Change of Pain Complaint
- Change of Cognitive Dysfunction
|
29 |
Male |
32 Years to 52 Years (Adult) |
NCT00252629 |
RCD-001-05S |
|
November 2005 |
October 2008 |
November 2010 |
November 11, 2005 |
December 11, 2014 |
December 11, 2014 |
- VA Medical Center, Northport
Northport, New York, United States
|
|
| 40 |
NCT01437891 |
Completed |
Sentra AM® and Sentra PM® for Post-traumatic Stress Disorder (PTSD) and Gulf War Fibromyalgia (GWF) |
- Post-traumatic Stress Disorder
- Persian Gulf Syndrome
|
|
Observational
|
|
- Stephanie Pavlik
- Targeted Medical Pharma
|
Industry |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- SF-36 general health survey
- Epworth Sleepiness Scale
- CERQ-short
- PCL-Military
|
30 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT01437891 |
GWF001 |
GWF001 |
September 2011 |
January 2012 |
January 2012 |
September 21, 2011 |
February 6, 2012 |
|
- Targeted Medical Pharma
Los Angeles, California, United States
|
|
| 41 |
NCT03542383 |
Recruiting |
Treatment of Memory Disorders in Gulf War Illness With High Definition Transcranial Direct Cortical Stimulation |
- Memory Disorders
- Word Finding Difficulty
|
- Device: High Definition Transcranial Direct Current Stimulation
- Device: Sham High Definition Transcranial Direct Current Stimulation
|
Interventional
|
Not Applicable |
- The University of Texas at Dallas
- University of Texas Southwestern Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in performance on the Controlled Oral Word Association Test (COWAT)
- Change in the performance on the California Verbal Learning Test (CVLT)
- Change in the performance on the Semantic Object Retrieval Test (SORT)
- (and 2 more...)
|
120 |
All |
45 Years to 78 Years (Adult, Older Adult) |
NCT03542383 |
16-64
CDMRP-GW150060 |
GWI HDtDCS |
February 1, 2017 |
September 29, 2019 |
September 29, 2019 |
May 31, 2018 |
May 31, 2018 |
|
- Callier Center for Communication Disorders at The University of Texas at Dallas
Dallas, Texas, United States
|
|
| 42 |
NCT00007722 |
Completed |
Amyotrophic Lateral Sclerosis (ALS) Gulf War Study |
- Amyotrophic Lateral Sclerosis
|
|
Observational
|
|
- US Department of Veterans Affairs
- United States Department of Defense
- Centers for Disease Control and Prevention
- (and 3 more...)
|
U.S. Fed / Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Probability of ALS among veterans both deployed and non-deployed to the Gulf Region(8/2/1990-7/31/1991)
|
135 |
All |
18 Years and older (Adult, Older Adult) |
NCT00007722 |
500 |
|
July 2000 |
March 2003 |
March 2003 |
January 1, 2001 |
October 9, 2009 |
|
- VA Medical Center
Durham, North Carolina, United States
|
|
| 43 |
NCT01956279 |
Active, not recruiting |
Complementary Neurosteroid Intervention in Gulf War Illnesses (GWVI) |
- Fatigue
- Musculoskeletal Pain
- Cognitive Decline
|
- Drug: Pregnenolone
- Drug: Placebo
|
Interventional
|
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Physical Component of the SF-36; assessing change between the baseline score (week 2), week 6 and week 10.
- Brief Pain Inventory; assessing change between the baseline score (week 2), week 6 and week 10
- Tower of London test of the Brief Assessment Checklist for Adolescents (BAC-A); assessing change between the baseline score (week 2), week 6 and week 10.
- (and 2 more...)
|
140 |
All |
40 Years to 65 Years (Adult, Older Adult) |
NCT01956279 |
SPLD-013-12S |
|
October 1, 2013 |
December 31, 2018 |
March 31, 2019 |
October 8, 2013 |
October 29, 2018 |
|
- Durham VA Medical Center, Durham, NC
Durham, North Carolina, United States
|
|
| 44 |
NCT00007735 |
Completed |
Antibiotic Treatment of Gulf War Veterans' Illnesses |
- Persian Gulf Syndrome
- Mycoplasma Infections
|
- Drug: Doxycycline (200mg/day) or Placebo
|
Interventional
|
Phase 3 |
- US Department of Veterans Affairs
- Pfizer
- United States Department of Defense
- VA Office of Research and Development
|
U.S. Fed / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
|
|
450 |
All |
Child, Adult, Older Adult |
NCT00007735 |
475 |
|
January 1999 |
|
October 2001 |
January 1, 2001 |
January 21, 2009 |
|
- Vamc - Birmingham, Al
Birmingham, Alabama, United States - Naval Health Research Center Merchant Illness Divi
San Diego, California, United States - Uniformed Services University Department of Psychi
Washington, District of Columbia, United States - (and 24 more...)
|
|
| 45 |
NCT00007514 |
Completed |
Investigate Olfactory Functioning as a Possible Proxy for Neurotoxic Exposure in Cohorts of Deployed and Non-Deployed Gulf War-Era Veterans. |
- Persian Gulf Syndrome
- Occupational Exposure
|
|
Observational
|
|
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
|
|
|
All |
18 Years and older (Adult, Older Adult) |
NCT00007514 |
723D |
|
March 2000 |
|
February 2001 |
January 1, 2001 |
January 21, 2009 |
|
- Vamc - New Orleans, La
New Orleans, Louisiana, United States
|
|
| 46 |
NCT01350492 |
Recruiting |
Impact of Exercise Training on Pain and Brain Function in Gulf War Veterans |
- Chronic Musculoskeletal Pain
|
- Behavioral: Resistance Exercise Training
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Symptoms
- Physical Activity
- Brain Structure and Function
|
68 |
All |
35 Years to 65 Years (Adult, Older Adult) |
NCT01350492 |
SPLD-004-10S |
|
April 16, 2013 |
October 31, 2018 |
December 31, 2018 |
May 9, 2011 |
September 19, 2018 |
|
- William S. Middleton Memorial Veterans Hospital, Madison, WI
Madison, Wisconsin, United States
|
|
| 47 |
NCT02791893 |
Recruiting |
Vagus Nerve Stimulation: Treatment for Gulf Veterans With Gulf War Illness |
|
- Device: VNS device
- Device: Inactive device
|
Interventional
|
Not Applicable |
- Benjamin H Natelson
- Icahn School of Medicine at Mount Sinai
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Visual Analog Scale (VAS) to assess change of widespread pain
- Patient Global Improvement of Change (PGIC)
- Short Form-36 (SF-36)
- Number of migraine headache days
|
40 |
All |
42 Years to 80 Years (Adult, Older Adult) |
NCT02791893 |
GCO 16-0350 |
|
March 21, 2017 |
October 1, 2019 |
October 1, 2019 |
June 7, 2016 |
December 10, 2018 |
|
- East Orange Veterans Administration Medical Center
East Orange, New Jersey, United States - Lyons Campus of the VA New Jersey Health Care System
Lyons, New Jersey, United States - Mount Sinai Beth Israel
New York, New York, United States - Pain and Fatigue Study Center - Beth Israel Medical Center
New York, New York, United States
|
|
| 48 |
NCT02075489 |
Completed |
Acupressure for Pain Management and Fatigue Relief in Gulf War Veterans |
- Persian Gulf Syndrome
- Chronic Fatigue Syndrome
|
- Other: Acupressure treatment.
- Other: Reiki
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Piper Fatigue Scale
- Changes in corticomuscular coherence
|
7 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02075489 |
W81XWH1210567 |
|
September 2012 |
October 2017 |
October 2017 |
March 3, 2014 |
October 10, 2017 |
|
- Cleveland Clinic
Cleveland, Ohio, United States
|
|
| 49 |
NCT00956150 |
Unknown † |
Bacterial Overgrowth Associated With Chronic Multisymptom Illness Complex |
|
- Procedure: Lactulose Breath Test
- Drug: Rifaximin
- Drug: Placebo
|
Interventional
|
Phase 1 |
- Henry C. Lin, MD
- New Mexico VA Healthcare System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To compare the pattern of bacterial gas excretion in breath among Veterans with Gulf War Syndrome vs. Controls using Lactulose Breath Test
- To determine the response to antibiotic treatment in Gulf War Syndrome patients.
|
210 |
All |
21 Years and older (Adult, Older Adult) |
NCT00956150 |
HRRC 07-155 |
|
April 2009 |
March 2014 |
|
August 11, 2009 |
May 1, 2013 |
|
- New Mexico VA Healthcare System
Albuquerque, New Mexico, United States
|
|
| 50 |
NCT00032461 |
Completed |
Compare the Medical Conditions of Gulf War Veterans to Non-Deployed Veterans |
- Chronic Fatigue Syndrome
- Fibromyalgia
- Post-Traumatic Stress Disorder
- (and 2 more...)
|
|
Observational
|
|
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Time Perspective: Retrospective
|
|
2000 |
All |
Child, Adult, Older Adult |
NCT00032461 |
458 |
|
November 1998 |
|
April 2001 |
March 22, 2002 |
January 21, 2009 |
|
|
|
| 51 |
NCT03058952 |
Recruiting |
Groups for Regaining Our Wellbeing |
- Gulf War
- Fatigue
- Pain
- Depression
|
- Behavioral: Mindfulness-Based Stress Reduction
- Behavioral: Chronic Disease Self-Management Program
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Short Form McGill Pain Questionnaire (SF-MPQ-2) total score
- General Fatigue subscale of the Multidimensional Fatigue Inventory (MFI)
- Cognitive Failures Questionnaire (CFQ)
- (and 5 more...)
|
308 |
All |
18 Years and older (Adult, Older Adult) |
NCT03058952 |
SDR 15-197 |
GROW |
July 3, 2017 |
October 1, 2020 |
April 30, 2021 |
February 23, 2017 |
September 27, 2018 |
|
- VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States
|
|
| 52 |
NCT00810368 |
Completed
Has Results |
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI) |
|
- Drug: Carnosine
- Drug: Placebo
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Effect of Carnosine Supplementation on Chronic Fatigue Syndrome Severity Scores
- Subjects With Improved Diarrhea Symptoms
- Incremental Change in Fatigue Score From Baseline to Week 12
- (and 4 more...)
|
33 |
All |
34 Years to 82 Years (Adult, Older Adult) |
NCT00810368 |
2008-068
USAMRMC PR# W91ZSQ-7149-N602
HRPO Log No. A-14542.2 |
|
August 2008 |
July 2012 |
July 2012 |
December 18, 2008 |
May 8, 2018 |
August 18, 2016 |
- Georgetown University
Washington, District of Columbia, United States
|
|
| 53 |
NCT03342482 |
Recruiting |
Glutamate Neuro-Excitotoxicity in GWI |
|
- Other: Low-glutamate diet
|
Interventional
|
Not Applicable |
- American University
- Georgetown University
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Brain Glutamate Levels
- Symptom Change
- Cognitive Function
|
40 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03342482 |
IRB-2017-301 |
GWI |
November 14, 2017 |
May 31, 2020 |
August 31, 2020 |
November 17, 2017 |
January 9, 2018 |
|
- American University
Washington, District of Columbia, United States
|
|
| 54 |
NCT03560830 |
Active, not recruiting |
START & STOPP in GWI |
|
- Other: 2 submaximal exercise stress tests
|
Observational
|
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
|
52 |
All |
18 Years and older (Adult, Older Adult) |
NCT03560830 |
2015-0579 |
|
February 2016 |
May 30, 2020 |
September 30, 2020 |
June 18, 2018 |
June 18, 2018 |
|
- Georgetown University
Washington, District of Columbia, United States
|
|
| 55 |
NCT02848417 |
Recruiting |
Glutathione vs. Curcumin Clinical Trial |
|
- Drug: Curcumin
- Drug: Glutathione
- Other: Placebo
|
Interventional
|
Phase 1
Phase 2 |
- South Florida Veterans Affairs Foundation for Research and Education
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Biomarker response to therapy using a VO2 exercise test
- Biomarker response to therapy using cytokine panel
|
75 |
All |
35 Years to 70 Years (Adult, Older Adult) |
NCT02848417 |
4987 |
Glutathione |
April 2016 |
January 2019 |
January 2019 |
July 28, 2016 |
May 16, 2018 |
|
- Miami VA Center
Miami, Florida, United States
|
|
| 56 |
NCT03030794 |
Recruiting |
Alleviating Headache and Pain in GWI With Neuronavigation Guided rTMS |
- Gulf War Syndrome
- Headache
|
- Device: Repetitive transcranial magnetic stimulation
- Device: Repetitive transcranial magnetic stimulation (sham)
|
Interventional
|
Not Applicable |
- Veterans Medical Research Foundation
- United States Department of Defense
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Daily Headache and Pain Log
- Headache Impact Test 6 (HIT-6)
- 2 months for each subject (11 visits)
- (and 15 more...)
|
90 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03030794 |
H160047 |
|
December 2016 |
December 2018 |
December 2018 |
January 25, 2017 |
August 27, 2018 |
|
- Naval Medical Center San Diego
San Diego, California, United States - Veteran Affairs Hospital
San Diego, California, United States
|
|
| 57 |
NCT00007748 |
Completed |
Exercise and Behavioral Therapy Trial (EBT). |
|
- Behavioral: Aerobic exercise
- Behavioral: Cognitive behavioral therapy
|
Interventional
|
Phase 3 |
- US Department of Veterans Affairs
- United States Department of Defense
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
1064 |
All |
18 Years and older (Adult, Older Adult) |
NCT00007748 |
470 |
|
March 1999 |
|
August 2001 |
January 1, 2001 |
June 26, 2015 |
|
- Birmingham Vamc Birmingham Vamc
Birmingham, Alabama, United States - Birmingham Vamc
Birmingham, Alabama, United States - Naval Health Research Center, San Diego
San Diego, California, United States - (and 26 more...)
|
|
| 58 |
NCT01782378 |
Active, not recruiting |
Scalp Application of Red and Near-Infrared Light, From Light-Emitting Diodes (LED) to Improve Thinking and Memory in Veterans With Gulf War Illnesses |
- Persian Gulf Syndrome
- Neurobehavioral Manifestations
- Memory Disorders
|
- Device: Photomedex or Thor Photomedicine Helmet, with Near-Infrared Light-Emitting Diodes (LEDs), Sham Helmet is identical but has power output of 0.
- Device: Intranasal LED device, Sham intranasal device appears identical but has power output of 0.
|
Interventional
|
Phase 2 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Attention/Executive Function
- Additional Attention/Executive Function
- Learning and Memory
- (and 3 more...)
|
160 |
All |
38 Years to 65 Years (Adult, Older Adult) |
NCT01782378 |
SPLD-014-12S
1I01CX000524-01A1 |
LED Treat GWVI |
December 1, 2014 |
September 30, 2018 |
July 13, 2019 |
February 1, 2013 |
October 2, 2018 |
|
- San Francisco VA Medical Center, San Francisco, CA
San Francisco, California, United States - VA Boston Healthcare System Jamaica Plain Campus, Jamaica Plain, MA
Boston, Massachusetts, United States
|
|
| 59 |
NCT00680836 |
Completed
Has Results |
Gulf War Digestive Health Study |
- Irritable Bowel Syndrome
- Small Intestinal Bacterial Overgrowth
|
- Drug: Placebo
- Drug: Rifaximin
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Global Improvement Scale
- Change in Stool Frequency (Number of Bowel Movements Per Day)
- Change in Stool Consistency
- (and 3 more...)
|
54 |
All |
35 Years to 72 Years (Adult, Older Adult) |
NCT00680836 |
GWRA-014-05F |
|
October 2007 |
October 2008 |
December 2013 |
May 20, 2008 |
August 29, 2014 |
August 29, 2014 |
- Division of Epidemiology
Salt Lake City, Utah, United States
|
|
| 60 |
NCT02825654 |
Recruiting |
Service and Health Among Deployed Veterans |
|
|
Observational
|
|
- VA Office of Research and Development
- United States Department of Defense
- Harvard University
|
U.S. Fed / Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Current forced expiratory volume in 1 second (FEV1)
- Current forced vital capacity (FVC)
- Current FEV1/FVC ratio
- Pharmaceutically-treated asthma
|
6200 |
All |
Child, Adult, Older Adult |
NCT02825654 |
595 |
SHADE |
March 8, 2018 |
April 30, 2022 |
October 31, 2023 |
July 7, 2016 |
February 4, 2019 |
|
- VA San Diego Healthcare System, San Diego, CA
San Diego, California, United States - Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States - VA Boston Healthcare System West Roxbury Campus, West Roxbury, MA
West Roxbury, Massachusetts, United States - (and 3 more...)
|
|
| 61 |
NCT00100425 |
Completed |
Characterization of Pain Processing Mechanisms in Irritable Bowel Syndrome |
|
- Procedure: Viceral Perception Testing
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: Double
- Primary Purpose: Diagnostic
|
|
|
All |
18 Years to 72 Years (Adult, Older Adult) |
NCT00100425 |
CADE-ARCD2 |
|
September 2000 |
|
|
December 31, 2004 |
January 21, 2009 |
|
- Malcolm Randall VA Medical Center
Gainesville, Florida, United States
|
|
| 62 |
NCT01608321 |
Terminated
Has Results |
rTMS for the Treatment of Chronic Pain in GW1 Veterans |
|
- Device: rTMS
- Device: Sham device
|
Interventional
|
Phase 3 |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Change in the Brief Pain Inventory (Short Form) Score
|
17 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT01608321 |
SPLD-001-11F |
rTMS |
September 2012 |
June 2015 |
September 2015 |
May 31, 2012 |
April 11, 2017 |
April 11, 2017 |
- VA Palo Alto Health Care System, Palo Alto, CA
Palo Alto, California, United States
|
|
| 63 |
NCT00810329 |
Completed |
Proteomics of Cerebrospinal Fluid in Chronic Fatigue Syndrome |
- Chronic Fatigue Syndrome
- Fibromyalgia
- Gulf War Illness
- (and 3 more...)
|
|
Observational
|
|
- Georgetown University
- National Institute of Environmental Health Sciences (NIEHS)
- University of South Alabama
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Differences in the proteins in the fluid around the brain, between Chronic fatigue syndrome and Healthy subjects. These proteins may identify the disease and define its mechanism.
- Blood pressure differences in response to exercise, blood test and cerebrospinal fluid, questionnaire results and sensory nerve testing to determine the role(s) of altered nerve and brain function in Chronic fatigue syndrome.
|
160 |
All |
21 Years to 65 Years (Adult, Older Adult) |
NCT00810329 |
2006-481
R01ES015382 |
|
July 2007 |
April 2011 |
April 2011 |
December 18, 2008 |
February 25, 2014 |
|
- Georgetown University Hospital, 3800 Reservoir Rd NW
Washington, District of Columbia, United States
|
|
| 64 |
NCT00568555 |
Completed
Has Results |
Effects of Low Dose Naltrexone in Fibromyalgia |
- Fibromyalgia
- Persian Gulf Syndrome
|
- Drug: Low Dose Naltrexone
- Drug: Placebo - sugar pill
|
Interventional
|
Not Applicable |
- Stanford University
- American Fibromyalgia Syndrome Association
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percent Change in Pain Scores Between Baseline to End of Placebo Treatment and Between Baseline to End of LDN Treatment.
- Percent Change in Sleep Quality Scores Between Baseline to End of Placebo Treatment and Between Baseline to End of LDN Treatment.
- Percent Change in Fatigue Scores Between Baseline to End of Placebo Treatment and Between Baseline to End of LDN Treatment.
- (and 2 more...)
|
53 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00568555 |
SU-10232007-756
8948 |
|
June 2007 |
January 2010 |
January 2010 |
December 6, 2007 |
October 21, 2015 |
October 21, 2015 |
- Stanford University School of Medicine
Stanford, California, United States
|
|
| 65 |
NCT03008837 |
Active, not recruiting |
Feasibility Study: fMRI Evaluation of Auricular PENFS for Fibromyalgia |
|
- Device: Military Field Stimulator
- Other: Standard Therapy
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- fcMRI as a biomarker to investigate functionally correlated neural substrates of pain in patients undergoing PENFS
- Defense Veterans Pain Rating Scale (DVPRS)
- PROMIS measures
- (and 3 more...)
|
20 |
All |
20 Years to 60 Years (Adult) |
NCT03008837 |
F2113-M
1IK1RX002113-01A2 |
fMRI |
June 1, 2017 |
December 7, 2018 |
May 31, 2019 |
January 4, 2017 |
January 9, 2019 |
|
- Atlanta VA Medical and Rehab Center, Decatur, GA
Decatur, Georgia, United States
|
|
| 66 |
NCT00285246 |
Completed
Has Results |
Prospective Study of Veteran Health in Previously Deployed Soldiers |
|
|
Observational
|
|
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Non-Specific Physical Symptoms
- Physical Functional Status
- Mental Functional Status
- Health Care Utilization
|
838 |
All |
18 Years to 60 Years (Adult) |
NCT00285246 |
IIR 02-296 |
|
December 2005 |
February 2011 |
February 2011 |
February 1, 2006 |
May 12, 2015 |
October 6, 2014 |
- G.V. (Sonny) Montgomery VA Medical Center, Jackson, MS
Jackson, Mississippi, United States - East Orange Campus of the VA New Jersey Health Care System, East Orange, NJ
East Orange, New Jersey, United States
|
|
| 67 |
NCT01465477 |
Unknown † |
Influenza Vaccination in Fibromyalgia Patients |
|
- Biological: Inactivated split virion Influenza vaccine
- Biological: WHO recommended 2011 Influenza vacccine
|
Interventional
|
Not Applicable |
- Tel-Aviv Sourasky Medical Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- proportion of patients who achieve a titer of antibodies above 1/40, against each of the antigens included in the vaccine
- Number of adverse events
- Clinical changes post - vaccination
|
80 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT01465477 |
0332-11-TLV |
|
November 2011 |
June 2012 |
November 2012 |
November 4, 2011 |
November 4, 2011 |
|
- Rheumatology Institute, Tel Aviv Sourasky Medical Center
Tel Aviv, Israel
|
|
| 68 |
NCT01918774 |
Completed |
Cognitive Behavior Therapy for Work Success in Veterans With Mental Illness: A Pre-post Efficacy Study |
- Mental Disorders
- Mental Health Services
|
- Behavioral: Cognitive behavior therapy for work success (CBTw)
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change in competitive employment
- Steady competitive work
- Work effectiveness and work productivity
- (and 9 more...)
|
59 |
All |
18 Years and older (Adult, Older Adult) |
NCT01918774 |
D0943-W |
|
February 1, 2016 |
July 31, 2018 |
September 30, 2018 |
August 8, 2013 |
November 22, 2018 |
|
- Richard L. Roudebush VA Medical Center, Indianapolis, IN
Indianapolis, Indiana, United States
|
|
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