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1339 studies found for:    germ cell brain
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Rank Status Study
1 Completed Combination Chemotherapy and Radiation Therapy in Treating Patients With Germ Cell Tumors in the Brain
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: carboplatin;   Drug: cisplatin;   Drug: etoposide phosphate;   Drug: ifosfamide;   Procedure: adjuvant therapy;   Procedure: conventional surgery;   Procedure: neoadjuvant therapy;   Radiation: radiation therapy
2 Recruiting Melphalan, Carboplatin, Mannitol, and Sodium Thiosulfate in Treating Patients With Recurrent or Progressive CNS Embryonal or Germ Cell Tumors
Conditions: Adult Central Nervous System Germ Cell Tumor;   Adult Ependymoblastoma;   Adult Medulloblastoma;   Adult Pineoblastoma;   Adult Supratentorial Primitive Neuroectodermal Tumor;   Childhood Atypical Teratoid/Rhabdoid Tumor;   Childhood Central Nervous System Germ Cell Tumor;   Childhood Ependymoblastoma;   Medulloepithelioma;   Ototoxicity;   Recurrent Adult Brain Neoplasm;   Recurrent Childhood Central Nervous System Embryonal Neoplasm;   Recurrent Childhood Malignant Germ Cell Tumor;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Pineoblastoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor
Interventions: Drug: Carboplatin;   Drug: Mannitol;   Drug: Melphalan;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration;   Drug: Sodium Thiosulfate
3 Completed Combination Chemotherapy Followed by Bone Marrow and/or Peripheral Stem Cell Transplantation in Treating Patients With Recurrent Medulloblastoma or CNS Germ Cell Tumors
Conditions: Brain Tumor;   Central Nervous System Tumor
Interventions: Biological: Sargramostim;   Drug: cyclophosphamide;   Drug: melphalan;   Procedure: autologous bone marrow transplantation;   Procedure: bone marrow ablation with stem cell support;   Procedure: peripheral blood stem cell transplantation
4 Completed High-dose Chemotherapy With Autologous Stem Cell Rescue in Pediatric High-risk Brain Tumors
Condition: Brain Tumor
Intervention: Procedure: high-dose chemotherapy and autologous stem cell rescue
5 Unknown  Chemotherapy, Surgery, Radiation Therapy and Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Primary CNS Germ Cell Tumors
Condition: Brain and Central Nervous System Tumors
Interventions: Biological: filgrastim;   Drug: carboplatin;   Drug: cyclophosphamide;   Drug: etoposide;   Drug: thiotepa;   Procedure: autologous bone marrow transplantation;   Procedure: bone marrow ablation with stem cell support;   Procedure: conventional surgery;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
6 Recruiting A Prospective Study of Cabazitaxel in Patients With Non Seminomatous Germ-cell Tumors
Condition: Non-seminomatous Germ-cell Tumors
Intervention: Drug: Cabazitaxel
7 Completed
Has Results
Radiation Therapy Compared With Chemotherapy and Radiation Therapy in Treating Patients With Newly Diagnosed Primary Central Nervous System (CNS) Germ Cell Tumor
Conditions: Brain Tumor;   Central Nervous System Tumor
Interventions: Biological: filgrastim;   Drug: carboplatin;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: etoposide;   Radiation: radiation therapy
8 Unknown  High-Dose Chemotherapy and Stem Cell Transplant in Treating Patients With Metastatic Germ Cell Tumors That Have Not Responded to First-Line Therapy
Conditions: Brain and Central Nervous System Tumors;   Extragonadal Germ Cell Tumor;   Testicular Germ Cell Tumor
Interventions: Biological: filgrastim;   Biological: pegfilgrastim;   Drug: carboplatin;   Drug: cisplatin;   Drug: dexamethasone;   Drug: etoposide;   Drug: ifosfamide;   Other: high-dose chemotherapy with autologous stem cell rescue;   Other: laboratory biomarker analysis;   Procedure: autologous hematopoietic stem cell transplantation;   Procedure: peripheral blood stem cell transplantation
9 Recruiting Prospective Trial for the Diagnosis and Treatment of Intracranial Germ Cell Tumors
Condition: Intracranial Germ Cell Tumors
Interventions: Radiation: craniospinal irradiation;   Drug: Carboplatin, Etoposide, Ifosfamide;   Radiation: ventricular irradiation;   Drug: Cisplatin, etoposide, Ifosfamide (standard);   Drug: Cisplatin, Etoposide, Ifosfamide (high dose);   Radiation: focal irradiation
10 Completed
Has Results
Neoadjuvant Chemotherapy With or Without Second-Look Surgery Followed by Radiation Therapy With or Without Peripheral Stem Cell Transplantation in Treating Patients With Intracranial Germ Cell Tumors
Conditions: Brain Tumor;   Central Nervous System Tumors;   Childhood Germ Cell Tumor
Interventions: Drug: carboplatin;   Drug: etoposide;   Drug: ifosfamide;   Drug: thiotepa;   Procedure: adjuvant therapy;   Procedure: conventional surgery;   Procedure: neoadjuvant therapy;   Procedure: peripheral blood stem cell transplantation;   Radiation: radiation therapy
11 Completed Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors
Condition: Brain Tumor
Intervention: Drug: Phenylbutyrate
12 Withdrawn Neurocognitive Outcomes In Patients Treated With Radiotherapy For Five Or More Brain Metastases
Condition: Brain Metastases
Interventions: Radiation: Stereotactic radiosurgery (SRS);   Radiation: Whole brain radiation therapy (WBRT)
13 Completed Combination Chemotherapy in Treating Children With Newly Diagnosed Malignant Germ Cell Tumors
Conditions: Childhood Germ Cell Tumor;   Extragonadal Germ Cell Tumor
Interventions: Biological: bleomycin sulfate;   Biological: filgrastim;   Drug: cisplatin;   Drug: cyclophosphamide;   Drug: etoposide;   Procedure: conventional surgery;   Biological: MESNA
14 Completed Cisplatin and Etoposide Prior to Radiation Therapy in Treating Patients With CNS Tumors
Conditions: Brain and Central Nervous System Tumors;   Pediatric Germ Cell Tumor;   Extragonadal Germ Cell Tumor
Interventions: Drug: cisplatin;   Drug: etoposide;   Procedure: conventional surgery;   Procedure: neoadjuvant therapy;   Radiation: radiation therapy
15 Unknown  Etoposide, Carboplatin, and Bleomycin in Treating Young Patients Undergoing Surgery For Malignant Germ Cell Tumors
Conditions: Brain and Central Nervous System Tumors;   Childhood Germ Cell Tumor;   Extragonadal Germ Cell Tumor;   Ovarian Cancer
Interventions: Biological: bleomycin sulfate;   Drug: carboplatin;   Drug: etoposide;   Procedure: conventional surgery
16 Completed Ixabepilone in Treating Patients With Advanced Cisplatin-Refractory Germ Cell Tumors
Conditions: Brain and Central Nervous System Tumors;   Extragonadal Germ Cell Tumor;   Ovarian Cancer;   Testicular Germ Cell Tumor
Intervention: Drug: ixabepilone
17 Unknown  Gemcitabine, Paclitaxel, Ifosfamide, and Cisplatin in Treating Patients With Progressive or Relapsed Metastatic Germ Cell Tumors
Conditions: Brain and Central Nervous System Tumors;   Extragonadal Germ Cell Tumor;   Ovarian Cancer;   Testicular Germ Cell Tumor
Interventions: Biological: filgrastim;   Biological: lenograstim;   Biological: pegfilgrastim;   Drug: cisplatin;   Drug: gemcitabine hydrochloride;   Drug: ifosfamide;   Drug: paclitaxel
18 Terminated Amifostine to Protect From Side Effects of PSCT in Treating Patients With Solid Tumors
Conditions: Brain and Central Nervous System Tumors;   Childhood Germ Cell Tumor;   Chordoma;   Kidney Cancer;   Liver Cancer;   Neuroblastoma;   Ovarian Cancer;   Retinoblastoma;   Sarcoma
Interventions: Drug: amifostine trihydrate;   Drug: busulfan;   Drug: filgrastim;   Drug: melphalan;   Drug: thiotepa;   Procedure: peripheral blood stem cell transplantation (PBSC)
19 Completed Talabostat Combined With Temozolomide or Carboplatin in Treating Young Patients With Relapsed or Refractory Brain Tumors or Other Solid Tumors
Conditions: Brain and Central Nervous System Tumors;   Childhood Germ Cell Tumor;   Kidney Cancer;   Liver Cancer;   Neuroblastoma;   Ovarian Cancer;   Sarcoma;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: carboplatin;   Drug: talabostat mesylate;   Drug: temozolomide;   Other: pharmacological study
20 Completed Genetic Study of Newly Diagnosed Central Nervous System Tumors in Young Children
Condition: Central Nervous System Embryonal Neoplasm
Intervention:

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Study has passed its completion date and status has not been verified in more than two years.