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24 studies found for:    gdc-0973 | Open Studies
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Rank Status Study
1 Recruiting iMATRIXcobi: Safety and Pharmacokinetics of Cobimetinib in Pediatric and Young Adult Patients With Previously Treated Solid Tumors
Condition: Solid or Brain Tumor With Evidence of RAS/RAF/MEK/ERK Activation
Intervention: Drug: Cobimetinib
2 Recruiting Vemurafenib and Cobimetinib Combination in BRAF Mutated Melanoma With Brain Metastasis
Condition: Malignant Melanoma
Intervention: Drug: Cobimetinib + Vemurafenib combination treatment
3 Recruiting Single-agent Cobimetinib for Adults With Histiocytic Disorders
Condition: Histiocytic Disorders
Intervention: Drug: Cobimetinib
4 Recruiting Study of Neo-adjuvant Use of Vemurafenib Plus Cobimetinib for BRAF Mutant Melanoma With Palpable Lymph Node Metastases
Condition: Melanoma
Interventions: Drug: Vemurafenib;   Drug: Cobimetinib
5 Recruiting Neoadjuvant Vemurafenib + Cobimetinib in Melanoma: NEO-VC
Condition: Malignant Melanoma
Intervention: Drug: Vemurafenib + cobimetinib
6 Recruiting Vemurafenib Plus Cobimetinib in Metastatic Melanoma
Condition: Metastatic Melanoma
Interventions: Drug: Vemurafenib plus cobimetinib;   Device: Positron Emission Tomography;   Procedure: Tissue sampling;   Procedure: Blood sampling
7 Recruiting ML29255 Neoadjuvant Vemurafenib and Cobimetinib Melanoma
Condition: Stage IIIB-C Melanoma
Intervention: Drug: Vemurafenib and Cobimetinib
8 Recruiting XL888 + Vemurafenib + Cobimetinib for Unresectable BRAF Mutated Stage III/IV Melanoma
Conditions: Melanoma;   Skin Cancer
Interventions: Drug: XL888;   Drug: Vemurafenib;   Drug: Cobimetinib
9 Recruiting A Study of Cobimetinib in Combination With Paclitaxel as First-line Treatment for Patients With Metastatic Triple-negative Breast Cancer
Condition: Breast Cancer
Interventions: Drug: cobimetinib;   Drug: paclitaxel;   Drug: placebo
10 Not yet recruiting Induction Therapy With Vemurafenib and Cobimetinib to Optimize Nivolumab and Ipilimumab Therapy
Condition: Melanoma, Malignant, of Soft Parts
Intervention: Drug: Vemurafenib and Cobimetinib
11 Recruiting Study of Cobimetinib in Combination With Atezolizumab and Bevacizumab in Participants With Gastrointestinal and Other Tumors
Condition: Colorectal Cancer
Interventions: Drug: Atezolizumab;   Drug: Bevacizumab;   Drug: Cobimetinib
12 Recruiting A Study of Venetoclax in Combination With Cobimetinib and Venetoclax in Combination With Idasanutlin in Patients Aged >/= 60 Years With Relapsed or Refractory Acute Myeloid Leukemia Who Are Not Eligible for Cytotoxic Therapy
Condition: Leukemia, Myeloid, Acute
Interventions: Drug: Cobimetinib;   Drug: Idasanutlin;   Drug: Venetoclax
13 Recruiting Treatment of a Resistant Disease Using Decitabine Combined With Vemurafenib Plus Cobimetinib
Conditions: Metastatic Melanoma;   Melanoma;   BRAF-mutated Metastatic Melanoma;   V600EBRAF-mutated Metastatic Melanoma
Intervention: Drug: Vemurafenib + Cobimetinib, Decitabine
14 Recruiting Clinical Trial to Evaluate the Efficacy of Vemurafenib in Combination With Cobimetinib (Continuous and Intermittent) in BRAFV600-mutation Positive Patients With Unresectable Locally Advanced or Metastatic Melanoma
Condition: Melanoma
Intervention: Drug: vemurafenib and cobimetinib
15 Recruiting A Study of Atezolizumab Plus Cobimetinib and Vemurafenib Versus Placebo Plus Cobimetinib and Vemurafenib in Previously Untreated BRAFv600 Mutation-Positive Participants With Metastatic or Unresectable Locally Advanced Melanoma
Condition: Melanoma
Interventions: Drug: Atezolizumab;   Drug: Atezolizumab Placebo;   Drug: Cobimetinib;   Drug: Vemurafenib;   Drug: Vemurafenib Placebo
16 Recruiting A Study to Detect V-Raf Murine Sarcoma Viral Oncogene Homolog B1 (BRAF) V600 Mutation on Cell-Free Deoxyribonucleic Acid (cfDNA) From Plasma in Participants With Advanced Melanoma
Condition: Metastatic Melanoma, BRAF V600 Mutation Positive
Interventions: Drug: Cobimetinib;   Drug: Vemurafenib
17 Recruiting Evaluating the Efficacy and Safety of a Sequencing Schedule of Cobimetinib Plus Vemurafenib Followed by Immunotherapy With an Anti- PD-L1 Antibody in Patients With Unresectable or Metastatic BRAF V600 Mutant Melanoma
Condition: Malignant Melanoma
Interventions: Drug: Vemurafenib;   Drug: Cobimetinib;   Drug: Atezolizumab
18 Recruiting A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma
Condition: Colorectal Cancer
Interventions: Drug: Atezolizumab [TECENTRIQ];   Drug: Cobimetinib;   Drug: Regorafenib
19 Recruiting A Study Evaluating Herceptin/Perjeta, Tarceva, Zelboraf/Cotellic, and Erivedge Treatment Targeted Against Certain Mutations in Cancer Patients
Condition: Neoplasms
Interventions: Drug: Cobimetinib [Cotellic];   Drug: Erlotinib [Tarceva];   Drug: Pertuzumab [Perjeta];   Drug: Trastuzumab [Herceptin];   Drug: Vemurafenib [Zelboraf];   Drug: Vismodegib [Erivedge]
20 Recruiting A Study of Nivolumab by Itself or Nivolumab Combined With Ipilimumab in Patients With Advanced or Metastatic Solid Tumors
Condition: Advanced or Metastatic Solid Tumors
Interventions: Biological: Nivolumab;   Biological: Ipilimumab;   Drug: Cobimetinib

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Study has passed its completion date and status has not been verified in more than two years.