| 101 |
NCT02727348 |
Completed |
Sciatic Nerve Blocks With or Without Femoral Block Versus Spinal Anaesthesia in Patients Undergoing Diabetic Foot Surgery |
|
- Procedure: Sciatic with or without femoral block
- Procedure: Spinal anaesthesia
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Treatment
|
- Blood pressure or heart rate changes more than 30% of baseline after spinal or block is considered significant
- S-LANSS score in who receive FSNB versus SAB.
|
120 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02727348 |
201401-0658 |
|
May 2014 |
January 2016 |
February 2016 |
April 4, 2016 |
April 4, 2016 |
|
- University Malaya Medical Centre
Kuala Lumpur, Malaysia
|
| 102 |
NCT03411187 |
Recruiting |
Study on the Application of Convenient Foot-control Exhaust Method in Endoscopic Thyroidectomy |
- Thyroid Cancer
- Papillary Thyroid Carcinoma
- Thyroidectomy
- Endoscopy
|
- Device: used of the Pressure adjustable foot-control method
- Device: direct exhaust
|
Interventional |
Not Applicable |
- wangbo
- Fujian Medical University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Flap separation time
- Glandular excision time
- Central lymph node dissection time
- (and 6 more...)
|
100 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03411187 |
exhaust |
|
January 1, 2018 |
June 30, 2018 |
June 30, 2018 |
January 26, 2018 |
January 26, 2018 |
|
- Wen-xin ZHAO
Fuzhou, Fujian, China
|
| 103 |
NCT00494143 |
Completed
Has Results |
Metabolic Cost Savings for Transtibial Amputees Wearing the Controlled Energy Storage and Return (CESR) Foot |
|
- Device: CESR Prosthetic Foot
- Device: typical prosthetic foot
- Device: standardized prosthetic foot
|
Interventional |
Phase 3 |
- VA Office of Research and Development
- University of Michigan
|
U.S. Fed / Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Metabolic Oxygen Consumption During Ambulation
- Prosthetic Foot Push Off Peak Power
- Peak Intact Knee Loading
|
7 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00494143 |
A4372-R |
|
July 2007 |
May 2009 |
December 2012 |
June 29, 2007 |
June 9, 2014 |
June 9, 2014 |
- VA Puget Sound Health Care System, Seattle
Seattle, Washington, United States
|
| 104 |
NCT02632877 |
Completed |
Efficacy of Pirfenidone Plus MODD in Diabetic Foot Ulcers |
|
- Drug: Pirfenidone with MODD
- Drug: Ketanserin
|
Interventional |
Phase 1
Phase 2 |
- University of Guadalajara
- Cell Pharma, SA de CV
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- assessing change of ulcerated area
- mRNA levels of collagen type I alpha (COL-1a)
- mRNA levels of Transforming growth factor 1-beta (TGFb-1)
- (and 7 more...)
|
60 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT02632877 |
IBMMTG.14
ISSSTE/CEI/TR/2014/01
Institute of Molecular Biology |
|
January 2014 |
November 2015 |
December 2015 |
December 17, 2015 |
December 17, 2015 |
|
- Molecular Biology and Gene Therapy Institute
Guadalajara, Jalisco, Mexico - Hospital Valentín Gómez Farías
Zapopan, Jalisco, Mexico
|
| 105 |
NCT02902211 |
Recruiting |
Improving Mobility in Peripheral Artery Disease Using an Ankle Foot Orthosis |
- Peripheral Artery Disease
|
- Device: Ankle foot orthosis
- Other: Control/standard of care
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Maximum walking distance from the Gardner graded treadmill protocol.
|
50 |
All |
40 Years to 85 Years (Adult, Senior) |
NCT02902211 |
485-16-FB |
|
July 7, 2017 |
April 2022 |
April 2022 |
September 15, 2016 |
September 29, 2017 |
|
- Omaha VA Medical Center
Omaha, Nebraska, United States
|
| 106 |
NCT02652754 |
Active, not recruiting |
Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Diabetic Foot Ulcers |
|
|
Interventional |
Phase 1 |
- FirstString Research, Inc.
- Medical University of South Carolina
- Spartanburg Regional Healthcare System
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Measurement of aCT1 peptide (Active Pharmaceutical Ingredient in Granexin) levels in blood
|
16 |
All |
18 Years and older (Adult, Senior) |
NCT02652754 |
DFU-PK-300 |
|
September 2015 |
December 2017 |
April 2018 |
January 12, 2016 |
February 8, 2018 |
|
- Aiyan Diabetes Center
Augusta, Georgia, United States - Spartanburg Regional Healthcare System
Spartanburg, South Carolina, United States - Salem VA Medical Center
Salem, Virginia, United States
|
| 107 |
NCT01796808 |
Completed |
Fat Grafting for Pedal Fat Pad Atrophy |
|
- Procedure: Pedal Fat Grafting
- Other: Local anesthetic
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Demonstrate that autologous fat grafting decreases pedal pressure during gait and increase plantar tissue thickness.
- Autologous fat grafting will demonstrate durability over time due to its biologic compatibility
|
31 |
All |
18 Years and older (Adult, Senior) |
NCT01796808 |
PRO12100139 |
|
March 2013 |
April 2017 |
April 2017 |
February 22, 2013 |
February 14, 2018 |
|
- UPMC Department of Plastic Surgery
Pittsburgh, Pennsylvania, United States
|
| 108 |
NCT01839669 |
Terminated |
The CurePPaC Study - Analysing Non-surgical Treatment Strategies to Cure Pes Planovalgus Associated Complaints |
- Foot Injuries
- Posterior Tibial Tendon Dysfunction
|
- Device: Foot Orthoses Only
- Procedure: Foot Orthoses and Eccentric Exercise
- Device: Sham Foot Orthoses
|
Interventional |
Not Applicable |
- Bern University of Applied Sciences
- Swiss National Science Foundation
- University Hospital Inselspital, Berne
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Foot Function Index - total score
- Foot Function Index - subcategory pain
- Foot Function Index - subcategory disability
- Foot Function Index - subcategory activity limitation
|
7 |
All |
18 Years to 60 Years (Adult) |
NCT01839669 |
140928 |
|
July 2013 |
October 25, 2017 |
October 25, 2017 |
April 25, 2013 |
October 27, 2017 |
|
- Spital Netz Bern Ziegler
Bern, Switzerland - Klinik Sonnenhof Bern
Bern, Switzerland - Inselspital, University Hospital Bern
Bern, Switzerland - (and 3 more...)
|
| 109 |
NCT03153007 |
Completed |
Study of Subjects With Diabetic Foot Ulcer (DFU) |
|
|
Observational |
|
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Assessment of signs and symptoms, impacts on functioning and HRQoL among subjects with DFU
|
1 |
All |
18 Years and older (Adult, Senior) |
NCT03153007 |
207650 |
|
August 11, 2017 |
December 6, 2017 |
December 6, 2017 |
May 15, 2017 |
January 18, 2018 |
|
- GSK Investigational Site
Bethesda, Maryland, United States
|
| 110 |
NCT02844660 |
Active, not recruiting |
Dehydrated Human Umbilical Cord Allograft in the Management of Diabetic Foot Ulcers |
|
- Biological: EpiCord
- Other: Standard of Care
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete Ulcer Closure
- Study Safety Measurement
- Time to complete closure
- (and 5 more...)
|
130 |
All |
18 Years and older (Adult, Senior) |
NCT02844660 |
ECDFU001 |
|
July 2016 |
October 2017 |
December 2017 |
July 26, 2016 |
October 26, 2017 |
|
- Central Research Associates
Birmingham, Alabama, United States - Arizona Regional Medical Research (ARMR)
Tucson, Arizona, United States - ILD Research
Carlsbad, California, United States - (and 10 more...)
|
| 111 |
NCT01418456 |
Unknown † |
Outcomes of Non-infected Diabetic Foot Ulcers With/Without Antibiotics |
- Diabetes
- Foot Ulcers
- Infection
|
|
Interventional |
Phase 4 |
- King's College Hospital NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Care Provider)
- Primary Purpose: Treatment
|
- Time to healing of foot ulceration in each group
- • Percentage of patients who will develop clinical signs of infection over a follow up period of 20 weeks
- • Percentage of patients in each group that are healed at 20 weeks.
|
166 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT01418456 |
KADFUT
2010-022518-16 |
KADFUT |
August 2011 |
February 2012 |
February 2012 |
August 17, 2011 |
August 17, 2011 |
|
|
| 112 |
NCT00909883 |
Unknown † |
Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles) |
- Parkinson's Disease
- Foot Dystonia
|
- Drug: Botulinum Toxin: Xeomin
- Drug: Placebo
|
Interventional |
Phase 3 |
- University Hospital, Clermont-Ferrand
- Merz Pharmaceuticals
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- In a controlled double blind and randomized study, we want to show that intramuscular injections of botulinum toxin are beneficial to reduced dystonia and associated pain in patient with foot dystonia (compared to placebo injections).
- Efficiency comparison of injections made in leg muscle (Flexor digitorum longus) between injections made directly in foot muscle (Flexor digitorum brevis or quadratus plantae) - Effects of injections on pain and quality of life.
|
45 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT00909883 |
CHU-0051 |
RBHP 2008 |
September 2009 |
September 2011 |
September 2012 |
May 29, 2009 |
March 25, 2011 |
|
- CHU Gabriel-Montpied
Clermont-Ferrand, France - Hôpital La Pitié Salpétrière
Paris, France - Hôpital Haut-Levêque
Pessac, France - CHU Purpan
Toulouse, France
|
| 113 |
NCT00013286 |
Completed |
A Prospective Study of Endothelial Dysfunction and Diabetic Foot Ulcer Risk |
|
- Device: Prevention Diabetic Foot Ulcer
|
Observational |
|
- VA Office of Research and Development
|
U.S. Fed |
- Time Perspective: Prospective
|
|
750 |
All |
18 Years and older (Adult, Senior) |
NCT00013286 |
A2016R |
|
October 1999 |
|
September 2002 |
March 16, 2001 |
January 21, 2009 |
|
- VAMC, Seattle, WA
Seattle, Washington, United States
|
| 114 |
NCT02581488 |
Completed |
Use of Santyl in Diabetic Foot Ulcers |
- Diabetic Foot
- Foot Ulcer, Diabetic
|
- Biological: Santyl
- Other: Product containing silver
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean change in ulcer area at end of treatment
- Mean change in ulcer area at end of study
- Target ulcer infection rate
|
102 |
All |
18 Years and older (Adult, Senior) |
NCT02581488 |
017-101-09-035 |
|
October 2015 |
January 2017 |
January 27, 2017 |
October 21, 2015 |
February 9, 2017 |
|
- Sylmar, California, United States
- Melbourne, Florida, United States
- Baltimore, Maryland, United States
- (and 10 more...)
|
| 115 |
NCT01972061 |
Enrolling by invitation |
Foot/Hand Neuromodulation for Overactive Bladder (OAB) |
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Voiding frequency per day
- Urine volume per void
|
80 |
All |
18 Years and older (Adult, Senior) |
NCT01972061 |
PRO13020474 |
FootStim |
March 2014 |
December 2018 |
December 2019 |
October 30, 2013 |
January 11, 2018 |
|
- University of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
| 116 |
NCT01404559 |
Completed
Has Results |
Measures of Gait Efficiency of Three Multi-Axial, Vertical Shock and Energy Storing-Return Prosthetic Feet During Simple & Complex Mobility Activities |
|
- Device: Ossur Variflex prosthetic foot
- Device: Ossur Ceterus prosthetic foot
- Device: Endolite Elite Blade prosthetic foot
|
Interventional |
Not Applicable |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Obstacle Course Completion Time
- Bioenergetics Between Feet Components 21 Days After Fitting Prostheses
|
28 |
Male |
21 Years to 45 Years (Adult) |
NCT01404559 |
10193006 |
|
July 2012 |
June 2013 |
June 2013 |
July 28, 2011 |
December 15, 2014 |
December 15, 2014 |
- University of South Florida
Tampa, Florida, United States
|
| 117 |
NCT01898923 |
Recruiting |
Evaluate the Efficacy and Safety of WH-1 Ointment for the Treatment of Chronic Diabetic Foot Ulcers |
|
- Drug: WH-1 ointment
- Other: Aquacel® Hydrofiber® dressing
|
Interventional |
Phase 3 |
- Oneness Biotech Co., Ltd.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- The incidence of complete ulcer closure
- The time of healing rate
- change in ulcer area
- (and 2 more...)
|
236 |
All |
20 Years to 80 Years (Adult, Senior) |
NCT01898923 |
ON101CLCT02 |
WH-1 |
September 2012 |
June 2019 |
March 2020 |
July 15, 2013 |
January 24, 2018 |
|
- Clinical Research Division
Taipei, Taiwan
|
| 118 |
NCT00512538 |
Terminated |
Apligraf Versus Standard Therapy in the Treatment of Diabetic Foot Ulcers |
|
- Device: Bi-layered cell therapy (Apligraf)
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to complete wound healing (full epithelialization with no drainage)
- Incidence of complete healing
|
82 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00512538 |
CGS0769 B304 |
|
October 2000 |
|
September 2002 |
August 7, 2007 |
August 7, 2007 |
|
|
| 119 |
NCT01340807 |
Completed |
A Comparison of External Mechanical Work Between Different Prosthetic Feet |
- Traumatic Amputation of Lower Extremity
|
- Other: Specialized Functional Prosthetic Training
|
Interventional |
Not Applicable |
- Miami VA Healthcare System
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Symmetry in External Work
- Self Report and Performance Based Assessment Instruments
|
15 |
All |
40 Years to 65 Years (Adult) |
NCT01340807 |
8497.01
01 |
SEW |
March 2008 |
January 2010 |
January 2011 |
April 25, 2011 |
April 25, 2011 |
|
- Miami VAHS
Miami, Florida, United States
|
| 120 |
NCT02632929 |
Active, not recruiting |
Prevention of Amputation in Diabetic Foot Ulcers Using Amniotic Tissue |
|
|
Observational |
|
- Boise VA Medical Center
- Integra LifeSciences Corporation
|
U.S. Fed / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Limb salvage
- effective wound healing
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02632929 |
00816 |
|
July 2015 |
July 2019 |
September 2019 |
December 17, 2015 |
January 19, 2018 |
|
- Boise VAMC
Boise, Idaho, United States
|
| 121 |
NCT02497846 |
Completed |
TEOSYAL® PureSense Redensity [I] Injection Using MicronJet® Needle in the Treatment of Crow's Feet Wrinkles |
|
- Device: TEOSYAL® PureSense Redensity [I]/MicronJet®
|
Interventional |
Phase 4 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Crow's feet responder for the feasibility outcome
- Subject satisfaction for acceptability outcome
- Pain evaluated by the subject
|
15 |
All |
25 Years to 75 Years (Adult, Senior) |
NCT02497846 |
TEO-R1-1404 |
|
May 2015 |
October 2015 |
October 2015 |
July 15, 2015 |
April 8, 2016 |
|
- Docteur MICHEELS
Geneva, Switzerland
|
| 122 |
NCT01221207 |
Unknown † |
Instant Total Contact Cast to Heal Diabetic Foot Ulcers |
|
- Device: Total Contact Cast
- Device: Instant Total Contact Cast (ITCC)
- Device: Removable Cast Walker (RCW)
|
Interventional |
Not Applicable |
- University of Texas Southwestern Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Wound Evaluation and Healing: The lower extremity evaluation will include length, width, depth, and area of the ulcer before and after debridement.
- Evaluation of Complications: At each visit the study nurse will interview patients and determine if they have experienced any adverse events.
|
225 |
All |
18 Years and older (Adult, Senior) |
NCT01221207 |
UTSW - 7R01DK074483-04 |
ITCC |
October 2010 |
October 2012 |
October 2012 |
October 14, 2010 |
October 18, 2010 |
|
- University of Arizona
Tucson, Arizona, United States - Parkland Health & Hospital Systems
Dallas, Texas, United States - UT Southwestern Medical Center at Dallas
Dallas, Texas, United States - Scott & White
Temple, Texas, United States
|
| 123 |
NCT02356757 |
Recruiting |
Primary Prevention of Foot Complications in Diabetes |
|
- Behavioral: Personalized Behavioral Intervention
- Behavioral: Current Best Practice
|
Interventional |
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Ulcerative and non-ulcerative Foot lesions
- Foot care skills
- Foot-care education
- (and 8 more...)
|
404 |
All |
21 Years and older (Adult, Senior) |
NCT02356757 |
IIR 14-009 |
PATRIOT |
August 24, 2015 |
October 31, 2018 |
January 31, 2019 |
February 5, 2015 |
January 23, 2018 |
|
- Manhattan Campus of the VA NY Harbor Healthcare System, New York, NY
New York, New York, United States
|
| 124 |
NCT02870816 |
Recruiting |
Prospective, Comparitive, Randomized Study of Allograft Versus Skin Substitute in Non-healing Diabetic Foot Ulcers |
|
- Procedure: Tissue Engineered Skin Substitute
- Device: Offloading
- Procedure: Amnionic Membrane Graft
|
Interventional |
Not Applicable |
- Professional Education and Research Institute
- Musculoskeletal Transplant Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The number of participants out of 60 with complete healing of their diabetic foot ulcers as measured by complete epithialization of the foot wound comparing the two active treatment groups
- Proportion of wounds healed
- Time to healing/complete closure
- Cost effectiveness of each treatment modality.
|
60 |
All |
18 Years and older (Adult, Senior) |
NCT02870816 |
MTF-DFU-COMP-01 |
|
August 2016 |
May 2018 |
May 2018 |
August 17, 2016 |
January 3, 2018 |
|
- Martinsville Research Institute
Martinsville, Virginia, United States - Shenandoah Lower Extremity Research Institute
Roanoke, Virginia, United States - Professional Education and Research Institute
Roanoke, Virginia, United States
|
| 125 |
NCT02224742 |
Active, not recruiting |
LeucoPatch in the Management of Hard-to-heal Diabetic Foot Ulcers |
|
- Device: LeucoPatch
- Other: Usual care
|
Interventional |
Phase 4 |
- Nottingham University Hospitals NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
|
269 |
All |
18 Years and older (Adult, Senior) |
NCT02224742 |
12EN005
ISRCTN27665670 |
|
August 2013 |
September 2017 |
May 2018 |
August 25, 2014 |
January 31, 2018 |
|
- Steno Diabetes Center
Gentofte, Denmark - Herlev Hospital
Herlev, Denmark - Nordsjællands Hospital
Hillerød, Denmark - (and 29 more...)
|
| 126 |
NCT03239457 |
Completed |
Efficacy and Safety of Heberprot-P® in Patients With Advanced Diabetic Foot Ulcer in Dasman Diabetes Institute. |
|
|
Observational |
|
- Dasman Diabetes Institute
- Cuban Center for Genetic Engineering and Biotechnology
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Proportion of patients with 100% of the lesion area covered by granulation tissue.
- Time in which the formation of the granulation tissue 100%
- Need of major amputation
- Adverse events
|
50 |
All |
22 Years and older (Adult, Senior) |
NCT03239457 |
RA 2014-051 |
|
December 2015 |
February 2016 |
February 2016 |
August 4, 2017 |
August 4, 2017 |
|
|
| 127 |
NCT02666131 |
Recruiting |
A Study of Granexin Gel to Treat Diabetic Foot Ulcer |
|
- Drug: Granexin gel
- Drug: Vehicle gel
|
Interventional |
Phase 3 |
- FirstString Research, Inc.
- INC Research
- Medical University of South Carolina
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Incidence of complete wound closure at Week 12 based on investigator assessment
- Time in days to first complete wound closure of the target ulcer based on investigator assessment over the 12 week treatment period
|
368 |
All |
18 Years and older (Adult, Senior) |
NCT02666131 |
2015-DFU-302 |
|
July 2015 |
June 2019 |
December 2019 |
January 28, 2016 |
February 7, 2018 |
|
- Aiyan Diabetes Center
Augusta, Georgia, United States - Spartanburg Regional Health System
Spartanburg, South Carolina, United States
|
| 128 |
NCT03077256 |
Recruiting |
Burst Biologics Foot and Ankle Registry |
- Foot and Ankle Disorders
- Ankle Fusion, Osteotomy
|
- Device: BioBurst Fluid, Burst Allograft
|
Observational |
|
- Burst Biologics
- Smart-Surgical Inc. dba Burst Biologics
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Fusion (%) Number of fusion patients fused/all fusion patients operated
- Bone Consolidation (%) Number of osteotomy patients with bone consolidation/all osteotomy patients operated
- Visual Analog Scale (VAS)
- (and 3 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT03077256 |
FA002 |
|
March 24, 2017 |
July 1, 2018 |
October 1, 2018 |
March 10, 2017 |
April 17, 2018 |
|
- Georgetown University Medical Center
Washington, District of Columbia, United States - Rocky Mountain Foot and Ankle
Caldwell, Idaho, United States
|
| 129 |
NCT03209466 |
Recruiting |
Chlorhexidine Gluconate Solution at 0.125% vs Placebo for the Healing of Grade IIB Ulcers of Diabetic Foot |
|
- Drug: Chlorhexidine gluconate at 0.125%
- Drug: Placebo Comparator with physiological saline sterile solution
|
Interventional |
Phase 4 |
- Universidad de Guanajuato
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
35 |
All |
18 Years and older (Adult, Senior) |
NCT03209466 |
CHXDF |
|
May 11, 2017 |
December 15, 2018 |
December 30, 2018 |
July 6, 2017 |
February 5, 2018 |
|
- Universidad de Guanajuato
Leon, Guanajuato, Mexico
|
| 130 |
NCT01626781 |
No longer available |
A Randomized, Open-label Phase III Trial of Mapisal® Versus an Urea Hand-foot Cream as Prophylaxis for Capecitabine-induced Hand-foot Syndrome in Patients With Gastrointestinal Tumors or Breast Cancer |
- the Treatment Hand-foot Syndrome Patients With Gastrointestinal Tumors or Breast Cancer, Who Are Treated With Capecitabine
|
- Device: Mapisal
- Other: Urea hand-foot cream
|
Expanded Access |
|
|
Other |
|
|
|
All |
18 Years and older (Adult, Senior) |
NCT01626781 |
AIO-LQ-0111 |
PROCAPP |
|
|
|
June 25, 2012 |
October 22, 2013 |
|
- Universitätsmedizin Mannheim, III. Medizinische Klinik
Mannheim, Germany
|
| 131 |
NCT01798927 |
Terminated
Has Results |
Effect of Lower Extremity Ankle Foot Orthoses in Parkinson's Disease |
|
- Device: Ankle foot orthosis
|
Interventional |
Not Applicable |
- University of Texas Southwestern Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Step Length by Means of Computerized Gait Analysis From Initial to Final Testing
- Number of Participants With a Change in Electromyography of Key Lower Extremity Muscles From Initial to Final Testing
|
4 |
All |
50 Years to 75 Years (Adult, Senior) |
NCT01798927 |
PD AFO |
|
December 2012 |
July 2013 |
July 2013 |
February 26, 2013 |
August 3, 2015 |
August 3, 2015 |
- UT Southwestern Medical Center, School of Health Professions
Dallas, Texas, United States
|
| 132 |
NCT01408277 |
Completed
Has Results |
Using Santyl on Diabetic Foot Ulcers |
- Diabetic Foot Ulcers
- Diabetic Foot Wounds
|
- Biological: Santyl
- Procedure: Control
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean Percent Change in Wound Area
|
55 |
All |
18 Years and older (Adult, Senior) |
NCT01408277 |
017-101-09-030 |
|
August 2011 |
November 2012 |
March 2013 |
August 3, 2011 |
July 24, 2014 |
May 5, 2014 |
- Associated Foot and Ankle Specialists
Phoenix, Arizona, United States - Aung Foothealth Clinics
Tucson, Arizona, United States - Foot Healthcare Associates, PC
Southfield, Michigan, United States - (and 4 more...)
|
| 133 |
NCT02667327 |
Recruiting |
A Study of Granexin Gel in the Treatment of Diabetic Foot Ulcer |
|
- Drug: Granexin gel
- Other: Vehicle gel
|
Interventional |
Phase 3 |
- FirstString Research, Inc.
- INC Research
- Medical University of South Carolina
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Incidence of complete wound closure at Week 12 based on investigator assessment
- Time in days to first complete wound closure of the target ulcer based on investigator assessment over the 12 week treatment period
|
552 |
All |
18 Years and older (Adult, Senior) |
NCT02667327 |
2015-DFU-301 |
|
July 2015 |
June 2019 |
December 2019 |
January 28, 2016 |
February 7, 2018 |
|
- Aiyan Diabetes Center
Augusta, Georgia, United States - Spartanburg Regional Health System
Spartanburg, South Carolina, United States
|
| 134 |
NCT02070835 |
Unknown † |
Study of ReCell® Treating for Diabetic Foot Ulcers |
|
- Device: ReCell®
- Procedure: skin graft
|
Interventional |
Not Applicable |
- Hu Zhicheng
- First Affiliated Hospital, Sun Yat-Sen University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- healing rate
- recurrent rate
|
80 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT02070835 |
SYSU-2013-048 |
|
March 2013 |
June 2016 |
June 2016 |
February 25, 2014 |
August 11, 2015 |
|
- Department of Burn Surgery, The First Affiliated Hospital of Sun Yat-sen University
Guangzhou, Guangdong, China
|
| 135 |
NCT02880592 |
Recruiting |
Effect of Fresh Amniotic Membrane in the Treatment of Diabetic Foot Ulcers |
|
- Other: Affinity Allograft
- Other: Standard of care
|
Interventional |
Not Applicable |
- SerenaGroup, Inc.
- NuTech Medical, Inc
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to initial closure of diabetic foot ulcer
- Proportion of healed wounds
- Quality of Life measurement
- Incidence of adverse events
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02880592 |
NT-DFU-AFF-01 |
|
August 2016 |
August 2018 |
November 2018 |
August 26, 2016 |
November 6, 2017 |
|
- GF Professional Research
Miami Lakes, Florida, United States - Barry University Clinical Research
North Miami Beach, Florida, United States - Henry Ford Macomb Hospital
Clinton Township, Michigan, United States - (and 5 more...)
|
| 136 |
NCT01490879 |
Completed |
A Study to Investigate the Safety and Clinical Effect of Nexagon® as a Topical Treatment for Subjects With a Diabetic Foot Ulcer (DUNE) |
|
- Drug: Nexagon® Low Dose
- Drug: Nexagon® Medium Dose
- Drug: Nexagon® High Dose
- Drug: Nexagon® vehicle
|
Interventional |
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Incidence of Reference Diabetic Foot Ulcer (RDFU) complete closure determined by Investigator Assessment
- Percentage change in RDFU surface area
- Time to RDFU complete closure
- (and 3 more...)
|
168 |
All |
18 Years and older (Adult, Senior) |
NCT01490879 |
NEX-ULC-011 |
DUNE |
July 2012 |
February 2014 |
April 2014 |
December 13, 2011 |
May 1, 2014 |
|
- Associated Foot and Ankle Specialists, LLC
Phoenix, Arizona, United States - University of Arizona Medical Center
Tucson, Arizona, United States - Center For Clinical Research Inc.
Castro Valley, California, United States - (and 22 more...)
|
| 137 |
NCT01942772 |
Unknown † |
A Powered Ankle Foot Rehabilitation Orthosis |
|
- Device: Ankle-Foot Orthosis
|
Interventional |
Not Applicable |
- Beijing Institute of Technology
- China Rehabilitation Research Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- good performance of the ankle foot orthosis
|
2 |
All |
15 Years and older (Child, Adult, Senior) |
NCT01942772 |
byang421 |
|
January 2013 |
February 2013 |
|
September 16, 2013 |
September 16, 2013 |
|
- Beijing Institute of Technology
Beijing, Beijing, China
|
| 138 |
NCT02790931 |
Recruiting |
Effects of Foot Muscle Strengthening in Daily Activity in Diabetic Neuropathic Patients |
|
- Other: Intervention Group
|
Interventional |
Not Applicable |
- University of Sao Paulo General Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- daily physical activity
- Self selected gait speed
- Fast gait speed
- (and 11 more...)
|
77 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02790931 |
LaBiMPH |
|
August 2016 |
December 2019 |
December 2020 |
June 6, 2016 |
August 30, 2017 |
|
- Universidade de São Paulo
São Paulo, Brazil
|
| 139 |
NCT02599805 |
Unknown † |
Can Topical Oxygen Therapy (Natrox™) Improve Wound Healing in Diabetic Foot Ulcers? |
|
- Device: Natrox™ Oxygen Delivery System (ODS)
|
Interventional |
Phase 3 |
- St. Michael's Hospital, Toronto
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Comparative change in ulcer surface area
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT02599805 |
tba |
|
December 2015 |
December 2016 |
December 2016 |
November 9, 2015 |
November 9, 2015 |
|
|
| 140 |
NCT02111291 |
Completed |
Santyl Applications to Diabetic Foot Ulcers |
- Diabetic Foot Ulcers
- Diabetic Foot Wounds
|
- Biological: Collagenase SANTYL® Ointment
- Biological: Hydrogel (if needed) and foam dressing
|
Interventional |
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to Well-established Granulation Tissue
- Adverse Event
|
215 |
All |
18 Years and older (Adult, Senior) |
NCT02111291 |
017-101-09-034 |
|
April 2014 |
December 2015 |
December 2015 |
April 11, 2014 |
February 17, 2016 |
|
- Mesa, Arizona, United States
- Carlsbad, California, United States
- Castro Valley, California, United States
- (and 22 more...)
|
| 141 |
NCT01581112 |
Completed |
Microbial Community Transplantation on the Armpit/Foot |
- Heavy, Bad Body Odour From Armpit
- Heavy, Bad Body Odour From Foot
|
- Biological: Microbial transplant
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in odour severity after bacterial transplantation
- Change in molecular characterisation of the bacterial community.
- Change in molecular characterisation of the bacterial community
|
4 |
All |
18 Years to 65 Years (Adult) |
NCT01581112 |
2012/256 |
|
September 2012 |
May 2013 |
June 2013 |
April 19, 2012 |
September 18, 2013 |
|
- Ghent University
Ghent, Belgium
|
| 142 |
NCT02818322 |
Recruiting |
The Role of Telemedical Monitoring in Diabetic Foot Ulcer Care |
- Diabetic Foot - Telemedical Monitoring
|
- Device: telemedical monitoring ( T)
- Device: classic monitoring
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
|
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT02818322 |
PA15083 |
A15-06 |
April 2016 |
October 2018 |
October 2018 |
June 29, 2016 |
June 29, 2016 |
|
- Chu de Reims
Reims, France
|
| 143 |
NCT01681160 |
Completed |
Study of Maggot Therapy in Diabetic Foot Ulcers |
|
- Other: procedure:maggot therapy
- Other: conventional therapy
|
Interventional |
Not Applicable |
- Kerman Medical University
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- change from baseline in BATES-JENSEN WOUND ASSESSMENT score at 3days and change from baseline in BATES-JENSEN WOUND ASSESSMENT score at 6 days
|
128 |
All |
40 Years to 90 Years (Adult, Senior) |
NCT01681160 |
86/116 |
MDT |
January 2009 |
December 2009 |
June 2011 |
September 7, 2012 |
September 10, 2012 |
|
|
| 144 |
NCT00134550 |
Completed |
Improving Diabetic Foot Ulcers With Atorvastatin |
|
- Drug: Atorvastatin (10 mg or 80 mg)
|
Interventional |
Phase 2 |
- Asker & Baerum Hospital
- Pfizer
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To assess the efficacy of atorvastatin in patients with foot ulcers and type 1 or type 2 diabetes mellitus receiving conventional foot ulcer treatment in improving foot ulcer treatment with regards to completely healed DFU, recurrence of DFU or novel DFU
- Time to complete healing (during 26 weeks of study)
- Recurrence rate of foot ulcers (during 26 weeks of study)
- (and 2 more...)
|
13 |
All |
30 Years and older (Adult, Senior) |
NCT00134550 |
The IDUS trial |
|
February 2005 |
March 2007 |
March 2007 |
August 25, 2005 |
September 23, 2009 |
|
- Asker and Baerum Hospital
RUD, Norway - Østfold County Hospital
Sarpsborg, Norway
|
| 145 |
NCT01221194 |
Unknown † |
Therapeutic Stockings to Prevent Foot Ulcers |
|
- Behavioral: Standard therapy
- Device: PFC Stockings
|
Interventional |
Not Applicable |
- University of Texas Southwestern Medical Center
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
- The main clinical outcome is ulceration of the foot to evaluate the effectiveness of a stocking as a prevention tool
|
400 |
All |
18 Years and older (Adult, Senior) |
NCT01221194 |
UTSW - 7R01DK070046-04 |
|
October 2010 |
October 2012 |
October 2012 |
October 14, 2010 |
October 14, 2010 |
|
- Parkland Health & Hospital Systems
Dallas, Texas, United States - UT Southwestern Medical Center at Dallas
Dallas, Texas, United States - Scott & White
Temple, Texas, United States - University of Manchester
Manchester, United Kingdom
|
| 146 |
NCT03370874 |
Not yet recruiting |
Clinical Study to Evaluate Efficacy and Safety of ALLO-ASC-DFU in Patients With Diabetic Foot Ulcers. |
|
- Biological: ALLO-ASC-DFU
- Procedure: Vehicle sheet
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Proportions of subjects who achieved complete wound closure
- Time taken to complete wound closure between the two groups
- Proportions of subjects who achieved complete wound closure by the classification of Wagner Grade between the two groups
- (and 2 more...)
|
164 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03370874 |
ALLO-ASC-DFU-301 |
|
February 2018 |
December 2019 |
December 2019 |
December 13, 2017 |
January 10, 2018 |
|
|
| 147 |
NCT03170687 |
Recruiting |
Comparative Outcomes Between Foot Cast and Short Leg Cast in the Patients With Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II) |
- Acute Closed Fracture of Proximal Fifth Metatarsal (Zone II)
|
- Device: short foot cast
- Device: short leg cast
|
Interventional |
Not Applicable |
- Jatupon Kongtharvonskul
- Police General Hospital
- Ramathibodi Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- VAS
- AOFAS
- union rate
- complication
|
100 |
All |
15 Years and older (Child, Adult, Senior) |
NCT03170687 |
53/2560 |
|
January 24, 2017 |
January 2019 |
January 2019 |
May 31, 2017 |
May 31, 2017 |
|
- Jatupon Kongtharvonskul
Bangkok, Select..., Thailand
|
| 148 |
NCT01097850 |
Withdrawn |
Topical Henna Preparation for the Treatment of Hand Foot Skin Syndrome |
|
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- • To compare the severity of HFS in subjects receiving topical natural henna paste treatment along with using CeraVe™ moisturizing cream concurrently on the treatment side and using only CeraVe™ moisturizing cream on the control side.
- To examine quality of life, comparing natural henna treatment versus CeraVe™ alone, using the Skindex-16 questionnaire
|
0 |
All |
18 Years and older (Adult, Senior) |
NCT01097850 |
NU 09D1 |
|
March 2010 |
January 2012 |
January 2012 |
April 2, 2010 |
December 12, 2014 |
|
|
| 149 |
NCT03341559 |
Not yet recruiting |
Spatial Frequency Domain Imaging (SFD) for Assessment of Diabetic Foot Ulcer Development and Healing |
|
- Other: Spatial Frequency Domain Imaging (SFDI)
|
Observational |
|
- University of Southern California
- Modulated Imaging Inc.
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Perfusion in lower extremities
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT03341559 |
APP-17-06886 |
|
December 1, 2017 |
December 31, 2019 |
May 1, 2020 |
November 14, 2017 |
November 14, 2017 |
|
|
| 150 |
NCT03248466 |
Recruiting |
PRG Combined With Autologous BMMSCs for Treatment of Diabetic Foot Ulcer |
|
- Biological: PRG combined with BMMSCs transplantation
|
Interventional |
Early Phase 1 |
- Third Military Medical University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Amputation rate
- hospital stay
- Wound healing time
- Transcutaneous oxygen partial pressure
|
60 |
All |
20 Years to 70 Years (Adult, Senior) |
NCT03248466 |
endocrine department of TMMU |
|
August 30, 2017 |
January 1, 2020 |
July 1, 2020 |
August 14, 2017 |
August 14, 2017 |
|
- Southwest Hospital of the Third Military Medical University
Chongqing, Chongqing, China - Endocrine Department, the First Affiliated Hospital of the Third Military Medical University
Chongqing, Chongqing, China
|
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