20 studies found for:    dichloroacetate
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Rank Status Study
1 Not yet recruiting Trial of Dichloroacetate in Pyruvate Dehydrogenase Complex Deficiency:
Condition: Pyruvate Dehydrogenase Complex Deficiency
Interventions: Drug: Dichloroacetate (DCA);   Other: Placebo;   Genetic: Genotype
2 Active, not recruiting Dichloroacetate Treatment of Congenital Lactic Acidosis Phase B: Open Label
Condition: Mitochondrial Enzyme Deficiencies
Intervention: Drug: Dichloroacetate
3 Recruiting Role of Preoperative Carbohydrates Drinks, Dichloroacetate and Exercise on Postoperative Muscle Insulin Resistance
Condition: Insulin Resistance
Interventions: Drug: Dichloroacetate;   Dietary Supplement: Carbohydrate drinks;   Behavioral: Moderate intensity exercise
4 Completed Dichloroacetate (DCA) for the Treatment of Pulmonary Arterial Hypertension
Condition: Pulmonary Hypertension (Idiopathic, Familial or Anorexigen-associated)
Intervention: Drug: Dichloroacetate Sodium
5 Active, not recruiting Study of DCA (Dichloroacetate) in Combination With Cisplatin and Definitive Radiation in Head and Neck Carcinoma
Condition: Squamous Cell Carcinoma of the Head and Neck
Interventions: Drug: DCA (dichloroacetate);   Drug: Placebo
6 Completed 13C-Pyruvate Breath Test
Condition: Healthy
Intervention: Drug: 13C-Pyruvate 13C-lactate and dichloroacetate
7 Completed Study of the Safety and Efficacy of Dichloroacetate (DCA) in Glioblastoma and Other Recurrent Brain Tumors
Conditions: Brain Tumor;   Glioblastoma
Intervention: Drug: Dichloroacetate
8 Unknown  A Phase I, Open-Labeled, Single-Arm, Dose Escalation, Clinical and Pharmacology Study of Dichloroacetate (DCA) in Patients With Recurrent and/or Metastatic Solid Tumours
Condition: Neoplasms
Intervention: Drug: Dichloroacetate
9 Terminated Dichloroacetate (DCA) in Patients With Previously Treated Metastatic Breast or Non-Small Cell Lung Cancer (NSCL)
Conditions: Metastatic Breast Cancer;   Lung Cancer
Intervention: Drug: Herceptin plus DCA
10 Completed Prevention of Dichloroacetate Toxicity
Conditions: Acidosis, Lactic;   Chronic Disease
Interventions: Drug: Nitisinone (NTBC);   Drug: Dichloroacetate;   Behavioral: Low-tyrosin diet
11 Completed The Safety and Efficacy of DCA for the Treatment of Brain Cancer
Condition: Malignant Gliomas, Glioblastoma Multiforme
Intervention: Drug: Dichloroacetate (DCA)
12 Withdrawn Combining Radiotherapy and Temozolomide With Dichloroacetate in Patients With Newly Diagnosed Glioblastoma
Condition: Glioblastoma
Intervention: Drug: Dichloroacetate (DCA)
13 Completed Dichloroacetate Kinetics, Metabolism and Toxicology
Condition: Lactic Acidosis
Intervention: Drug: Dichloroacetate
14 Completed
Has Results
Pharmacotoxicology of Trichloroethylene Metabolites
Condition: Healthy
Interventions: Drug: Dichloroacetate environmental dose;   Drug: Chloral Hydrate environmental dose;   Drug: Dichloroacetate therapeutic dose;   Drug: Chloral Hydrate therapeutic dose
15 Terminated
Has Results
Pharmacotoxicology of Trichloroethylene Metabolites
Condition: Healthy
Interventions: Drug: Dichloroacetate;   Genetic: Genotyping;   Other: Leucine;   Other: tyrosine
16 Completed
Has Results
Pharmacotoxicology of Trichloroethylene Metabolites
Condition: Congenital Lactic Acidosis
Interventions: Drug: Dichloroacetate (DCA);   Genetic: Genetic Marker on Chromosome 14q24.3
17 Unknown  Evaluating the Effectiveness of a Dichloroacetate in MELAS Syndrome
Condition: MELAS Syndrome
Intervention: Drug: Dichloroacetate
18 Completed Phase III Randomized Study of Sodium Dichloroacetate in Children With Congenital Lactic Acidosis
Condition: Lactic Acidosis
Intervention: Drug: sodium dichloroacetate
19 Completed Phase II Pilot Randomized Study of Sodium Dichloroacetate in Patients With Congenital Lactic Acidemia
Condition: Lactic Acidosis
Intervention: Drug: sodium dichloroacetate
20 Active, not recruiting Phase I Trial of Metabolic Reprogramming Therapy for Treatment of Recurrent Head and Neck Cancers
Conditions: Head and Neck Cancer;   Head and Neck Cancers
Interventions: Drug: Dichloroacetate;   Device: EF5

Indicates status has not been verified in more than two years