| 101 |
NCT00001259 |
Recruiting |
A Treatment Study for Premenstrual Syndrome (PMS) |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
100 |
Female |
18 Years to 50 Years (Adult) |
NCT00001259 |
900088
90-M-0088 |
|
March 9, 1990 |
|
|
November 4, 1999 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 102 |
NCT02840071 |
Not yet recruiting |
ACT for Distress in Head and Neck Cancer Patients |
|
- Other: Psychological therapy
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in psychological flexibility assessed using the Acceptance and Action Questionnaire (AAQ-II)
- Change in psychological flexibility assessed using the Problem Questionnaire (PQ)
- Depression assessed by PHQ-9 questionnaire
- Anxiety assessed by GAD-7 questionnaire
|
3 |
All |
18 Years and older (Adult, Senior) |
NCT02840071 |
16067 |
|
October 2016 |
March 2017 |
March 2017 |
July 21, 2016 |
July 21, 2016 |
|
- City Hospital
Nottingham, Notitnghamshire, United Kingdom - King's Mill Hospital
Mansfield, Nottinghamshire, United Kingdom
|
| 103 |
NCT02851706 |
Recruiting |
Natural History of and Specimen Banking for People With Tumors of the Central Nervous System |
- Brain Cancer
- Brain Tumor
- Spine Cancer
- (and 2 more...)
|
|
Observational |
|
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To evaluate patients with tumors of the central nervous system (CNS) who are probable future candidates for NCI Phase I and II protocols
- To follow patients with tumors of the CNS that are representative ofimportant scientific and/or clinical principles
- To follow patients with CNS tumors that are understudied or haveindeterminate natural history
- To evaluate and follow patients with known genetic syndromes at high risk of developing CNS cancers
|
10000 |
All |
18 Years to 99 Years (Adult, Senior) |
NCT02851706 |
160151
16-C-0151 |
|
July 29, 2016 |
June 6, 2066 |
April 5, 2100 |
August 2, 2016 |
February 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
| 104 |
NCT02504866 |
Recruiting |
Effect of Exercise Training on Physical, Cognitive, and Behavioral Function in People With TBI |
|
|
Interventional |
Phase 1
Phase 2 |
- National Institutes of Health Clinical Center (CC)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in cognitive function (TMT-B)
- Change in cardiorespiratory fitness
- Change in motor assessment
|
80 |
All |
18 Years to 79 Years (Adult, Senior) |
NCT02504866 |
150164
15-CC-0164 |
|
December 15, 2016 |
December 31, 2018 |
December 30, 2019 |
July 22, 2015 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 105 |
NCT02950636 |
Recruiting |
Effect of Yoga on Mood and Quality of Life in Patients With Refractory Epilepsy |
|
|
Interventional |
Not Applicable |
- University of Kansas Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
- Change in Generalized Anxiety Disorder 7-item (GAD-7) scale
- Change in Quality of Life in Epilepsy-Patient-Weighted (QOLIE-31-p)
- Frequency of seizures
|
20 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02950636 |
STUDY00140045
UL1TR000001 |
|
December 2016 |
June 2017 |
June 2017 |
November 1, 2016 |
December 22, 2016 |
|
- University of Kansas Medical Center
Kansas City, Kansas, United States
|
| 106 |
NCT01187511 |
Completed
Has Results |
CRF1 Antagonist GSK561679 in Alcoholism |
|
- Drug: GSK561679
- Drug: Placebo
|
Interventional |
Phase 2 |
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Alcohol Craving in Response to the Alcohol Cue Script
- Alcohol Craving in Response to the Stress Script
- Alcohol Craving in Response to the Trier/Cue-reactivity Procedure
- (and 3 more...)
|
44 |
Female |
21 Years to 65 Years (Adult) |
NCT01187511 |
100046
10-AA-0046 |
|
January 2010 |
September 2015 |
September 2015 |
August 24, 2010 |
November 7, 2016 |
November 7, 2016 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 107 |
NCT00369915 |
Terminated
Has Results |
The Antidepressant Efficacy of the Anticholinergic Scopolamine |
- Unipolar Depression
- Bipolar Depression
|
|
Interventional |
Phase 2 |
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Depression Severity
- Hamilton Anxiety Rating Scale
|
17 |
All |
18 Years to 55 Years (Adult) |
NCT00369915 |
060234
06-M-0234 |
|
August 2006 |
January 2013 |
January 2013 |
August 30, 2006 |
November 10, 2016 |
April 29, 2016 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 108 |
NCT02317341 |
Recruiting |
Effect of Ketamine on Fatigue Following Cancer Therapy |
|
- Drug: Ketamine
- Drug: Placebo (saline)
- Drug: Midazolam
- Drug: Midazolam(placebo)
|
Interventional |
Early Phase 1 |
- National Institute of Nursing Research (NINR)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in fatigue score
- Cognition, muscle strength, depression
- Cytokines, neurotrophins, metabolic mark
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT02317341 |
150037
15-NR-0037 |
|
December 13, 2014 |
May 1, 2018 |
May 1, 2018 |
December 16, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 109 |
NCT00888563 |
Completed |
Fatigue in Healthy Individuals |
- Healthy Volunteer
- Fatigue
- Depression
|
|
Observational |
|
- National Institute of Nursing Research (NINR)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- fatigue score of healthy individuals using standardized questionnaires.
- Physical activity, pain, depression, stress, and daytime sleepiness scores; the HPA axis function of healthy individuals; the proinflammatory cytokine profile and gene expression in response to stress.
|
114 |
All |
18 Years and older (Adult, Senior) |
NCT00888563 |
090131
09-NR-0131 |
|
April 23, 2009 |
|
November 16, 2017 |
April 27, 2009 |
April 19, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 110 |
NCT02145429 |
Active, not recruiting |
Preventing Depression in Late Life: A Model for Low and Middle Income Countries |
- Depression
- Anxiety Disorder
|
- Behavioral: Problem Solving therapy and Brief Behavioral Treatment of Insomnia
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Institutes of Health (NIH)
- Goa Medical College
- Sangath
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Percent of participants who develop major depression and anxiety disorders
- General Health Questionnaire (GHQ)
- World Health Organization Disability Assessment Schedule (WHODAS-II)
|
120 |
All |
60 Years and older (Adult, Senior) |
NCT02145429 |
1R34MH096997-01A1 |
|
September 2013 |
December 31, 2018 |
December 31, 2018 |
May 22, 2014 |
January 23, 2018 |
|
- Goa Medical College
Bambolim, Goa, India
|
| 111 |
NCT01071538 |
Completed
Has Results |
Buprenorphine for Late-Life Treatment Resistant Depression |
|
|
Interventional |
Phase 2 |
- University of Pittsburgh
- National Institutes of Health (NIH)
- Reckitt Benckiser LLC
- National Center for Research Resources (NCRR)
|
Other / NIH / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Montgomery Asberg Depression Rating Scale
- Blood Pressure
- UKU Side Effect Rating Scale
- (and 4 more...)
|
15 |
All |
50 Years and older (Adult, Senior) |
NCT01071538 |
BUILD
KL2RR024154 |
BUILD |
May 2010 |
May 2012 |
May 2012 |
February 19, 2010 |
March 9, 2018 |
March 17, 2016 |
- Western Psychiatric Institute and Clinica, University of Pittsburgh School of Medicine
Pittsburgh, Pennsylvania, United States
|
| 112 |
NCT01783574 |
Completed
Has Results |
Testosterone Antidepressant Augmentation in Women |
|
- Drug: Testosterone
- Drug: Placebo
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Institutes of Health (NIH)
- Lawley Pharmaceuticals
|
Other / NIH / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Depressive Symptom Severity
- Fatigue
- Sexual Dysfunction
|
101 |
Female |
21 Years to 75 Years (Adult, Senior) |
NCT01783574 |
2012D000537
R34MH09931501A1 |
|
August 2013 |
January 27, 2017 |
January 27, 2017 |
February 5, 2013 |
April 5, 2018 |
April 5, 2018 |
- Massachusetts General Hospital
Boston, Massachusetts, United States - Butler Hospital
Providence, Rhode Island, United States
|
| 113 |
NCT01559857 |
Completed
Has Results |
Pioglitazone in Patients With Mood Disorders |
- Major Depressive Disorder
- Insulin Resistance
|
- Drug: Pioglitazone
- Drug: Sugar Pill
|
Interventional |
Phase 4 |
- Stanford University
- National Institutes of Health (NIH)
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hamilton Depression Rating Scale at Baseline
- Fasting Insulin Measurements at Baseline
- Change in HDRS-21: From Baseline to 12 Weeks
|
37 |
All |
20 Years to 65 Years (Adult) |
NCT01559857 |
R21MH093948-01A1 |
|
November 2011 |
January 2014 |
June 2014 |
March 21, 2012 |
May 10, 2017 |
May 10, 2017 |
- Stanford University Department of Psychiatry & Behavioral Sciences
Palo Alto, California, United States
|
| 114 |
NCT01227980 |
Completed
Has Results |
Corticotropin-Releasing Hormone Receptor 1 (CRH1) Antagonism in Anxious Alcoholics^ |
- Alcohol-Related Disorders
- Alcohol Dependence
- Alcoholism
- Anxiety Disorder
|
- Drug: Pexacerfont
- Drug: Placebo
|
Interventional |
Phase 2 |
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Alcohol Craving in Response to the Alcohol Cue Script
- Alcohol Craving in Response to the Stress Script
|
70 |
All |
21 Years to 65 Years (Adult) |
NCT01227980 |
110010
11-AA-0010 |
|
October 2010 |
July 2014 |
July 2014 |
October 25, 2010 |
February 2, 2016 |
December 10, 2015 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 115 |
NCT00111293 |
Completed |
Attention and Visual Perception |
- Focal Lesions
- Focal Brain Lesion
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
8 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00111293 |
050157
05-M-0157 |
|
May 16, 2005 |
|
May 14, 2010 |
May 19, 2005 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 116 |
NCT02093052 |
Active, not recruiting |
Intervening Early With Neglected Children |
- Conduct Disorder
- ADHD
- Depression
|
- Behavioral: Attachment and Biobehavioral Catch-up
- Behavioral: Developmental Education for Families
|
Interventional |
Phase 1
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Inhibitory control
- Emotion regulation
- Peer relations
- (and 16 more...)
|
220 |
All |
6 Years to 8 Years (Child) |
NCT02093052 |
NIH R01 74374 |
|
March 2005 |
January 2019 |
April 2019 |
March 20, 2014 |
March 20, 2018 |
|
- University of Delaware
Newark, Delaware, United States
|
| 117 |
NCT01692236 |
Terminated |
Brain Imaging for HIV-Associated Thinking and Mood Disorders |
- Human Immunodeficiency Virus
- Neurocognitive Impairment
|
|
Observational |
|
- National Institutes of Health Clinical Center (CC)
- National Institute of Allergy and Infectious Diseases (NIAID)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Neuropsychologic testing scores
- Serum biomarkers of cardiovascular disease and inflammation
- MRI brain and vascular findings
|
84 |
All |
25 Years to 61 Years (Adult) |
NCT01692236 |
120200
12-CC-0200 |
|
September 13, 2012 |
|
April 4, 2018 |
September 25, 2012 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 118 |
NCT02050867 |
Recruiting |
Validation of the Ask Suicide-Screening Questions (ASQ) in the Inpatient Medical Setting |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- Boston Children’s Hospital
- Children's Research Institute
- (and 2 more...)
|
NIH / Other |
- Time Perspective: Prospective
|
- Primary outcome measures include frequencies of positive responses to all ASQ and SIQ items.
|
600 |
All |
10 Years to 21 Years (Child, Adult) |
NCT02050867 |
999914044
14-M-N044 |
|
January 29, 2014 |
July 1, 2018 |
July 1, 2018 |
January 31, 2014 |
February 20, 2018 |
|
- Childrens National Medical Center
Washington, District of Columbia, United States - Childrens Hospital, Boston
Boston, Massachusetts, United States - Childrens Hospital, Columbus
Columbus, Ohio, United States
|
| 119 |
NCT00001174 |
Recruiting |
Evaluation of the Genetics of Bipolar Disorder |
- Mania
- Bipolar, Disorder
- Depression
- (and 3 more...)
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Family-Based
- Time Perspective: Retrospective
|
|
4000 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT00001174 |
800083
80-M-0083 |
|
August 4, 1980 |
|
|
November 4, 1999 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 120 |
NCT00005011 |
Completed |
Combined Hormone Replacement in Menstrually-Related Mood Disorders |
- Premenstrual Syndrome
- Depression
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
22 |
Female |
18 Years to 50 Years (Adult) |
NCT00005011 |
000103
00-M-0103 |
|
March 28, 2000 |
|
October 28, 2016 |
March 30, 2000 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 121 |
NCT00178165 |
Completed |
Coordinating Center for Enhancing ADRD Caregiving |
- Dementia
- Alzheimer Disease
|
- Procedure: Skill Training Condition – problem solving training
- Procedure: REACH for TLC (Telephone Linked Computer) system
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Institute on Aging (NIA)
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The outcomes were assessed 6 months after randomization and included a measure of burden and a measure of depression. Caregiver burden was assessed using the Revised Memory and Behavior Problem Checklist (RMBPC).
- Emotional distress was determined by the Center for Epidemiological Studies Depression Scale (CES-D) a global measure of depression.
- Long-term care placement of dementia patients and caregiver health and well-being
- (and 2 more...)
|
1200 |
All |
21 Years and older (Adult, Senior) |
NCT00178165 |
AG13305-01
NR13269
AG13313
AG13297
AG13289
AG13265
AG13255
AG13305 |
|
September 1996 |
|
November 2001 |
September 15, 2005 |
September 15, 2005 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Stanford University and Veterans Affairs
Menlo Park, California, United States - University of Miami at Miami, Center on Adult Development and Aging
Miami, Florida, United States - (and 2 more...)
|
| 122 |
NCT00263536 |
Completed |
Pilot Program for Targeted Prevention of Child or Adolescent Weight Gain |
- Overweight Adolescents
- Overweight
|
- Procedure: Interpersonal Psychotherapy
|
Interventional |
Phase 1 |
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
147 |
All |
8 Years to 13 Years (Child) |
NCT00263536 |
060039
06-CH-0039 |
|
December 5, 2005 |
August 16, 2016 |
August 16, 2016 |
December 8, 2005 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 123 |
NCT00446238 |
Completed |
Treatment of Depressed Adolescents With Physical Illness |
- Inflammatory Bowel Disease
- Depression
|
- Behavioral: Cognitive Behavioral Therapy
- Behavioral: Standard of Community Care Treatment
|
Interventional |
Not Applicable |
- University of Pittsburgh
- Harvard University
- Boston Children’s Hospital
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change from Baseline in CDI at 14 weeks
|
41 |
All |
11 Years to 17 Years (Child) |
NCT00446238 |
1K23MH064604-01A1 |
|
September 2002 |
August 2007 |
August 2007 |
March 12, 2007 |
May 20, 2014 |
|
- Children's Hospital Boston
Boston, Massachusetts, United States - Children's Hospital of Pittsburgh
Pittsburgh, Pennsylvania, United States
|
| 124 |
NCT00056602 |
Completed |
Clinically Important Changes in Rheumatoid Arthritis |
|
|
Observational |
|
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
192 |
All |
18 Years and older (Adult, Senior) |
NCT00056602 |
030133
03-AR-0133 |
|
March 18, 2003 |
|
|
March 19, 2003 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 125 |
NCT01217658 |
Completed |
Measuring and Reducing Excessive Infant Crying |
- Infant Colic
- Postpartum Depression
|
- Behavioral: The Happiest Baby on The Block
- Behavioral: AAP Infant Colic counseling
|
Interventional |
Not Applicable |
- The University of Texas Health Science Center, Houston
- National Institutes of Health (NIH)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Mean night-time crying
- Mean sleep duration
- Maternal Depression, Anxiety and Somatization
- Salivary Biomarkers
|
28 |
All |
up to 5 Weeks (Child) |
NCT01217658 |
HSC-MS-10-0392
K23HD065872 |
UTHealth THB |
January 2011 |
September 2015 |
September 2015 |
October 8, 2010 |
December 8, 2015 |
|
- University of Texas Health Science Center at Houston
Houston, Texas, United States
|
| 126 |
NCT00431366 |
Completed |
Sequence Effect in Parkinson's Disease |
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
24 |
All |
18 Years and older (Adult, Senior) |
NCT00431366 |
070088
07-N-0088 |
|
February 1, 2007 |
|
December 24, 2008 |
February 5, 2007 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 127 |
NCT02911077 |
Completed |
Longitudinal Changes in the Oral and Gut Microbiome of Individuals With Alcohol Dependence |
- Alcoholic Intoxication
- Alcohol-Related Disorders
|
|
Observational |
|
- National Institutes of Health Clinical Center (CC)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Other
- Time Perspective: Prospective
|
- Identification of bacteria in the gut and oral microbiomes over time
|
23 |
All |
18 Years and older (Adult, Senior) |
NCT02911077 |
160162
16-CC-0162 |
|
August 5, 2016 |
October 5, 2017 |
October 5, 2017 |
September 22, 2016 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
| 128 |
NCT02197663 |
Terminated |
Clinical Evaluation of Acupuncture on the Complications of Cerebral Vascular Accident |
|
- Procedure: acupuncture(44mm in length and 32-gauge)
|
Interventional |
Phase 1 |
- China Medical University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in Barthel index at 8 weeks
- Change from baseline in Barthel Index at 16 weeks
- Change from baseline in Barthel Index at 24 weeks
- (and 12 more...)
|
60 |
All |
40 Years and older (Adult, Senior) |
NCT02197663 |
CMUH102-REC2-015 |
|
April 2013 |
July 2015 |
July 2015 |
July 23, 2014 |
October 22, 2015 |
|
- Department of Acupuncture, China Medical University Hospital
Taichung, Taiwan
|
| 129 |
NCT02232126 |
Completed
Has Results |
Social Work Intervention Focused on Transitions |
- Study Focus: 30-day Rehospitalizations Among At-risk Older Adults Randomized to a Social Work-driven Care Transitions Intervention
- Heart Disease
- Diabetes
- (and 7 more...)
|
- Other: SWIFT home intervention
|
Interventional |
Not Applicable |
- University of Southern California
- Huntington Hospital
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- 30-day Hospital Readmission
- 30-day Readmission Among Intervention Participants
|
181 |
All |
65 Years and older (Adult, Senior) |
NCT02232126 |
UP-10-00372
5R21AG034557-02 |
SWIFT |
February 2011 |
October 2013 |
October 2013 |
September 5, 2014 |
February 10, 2017 |
February 10, 2017 |
- University of Southern California
Los Angeles, California, United States - Huntington Hospital
Pasadena, California, United States
|
| 130 |
NCT01143467 |
Completed |
Relationship Between Mitochondrial Dysfunction and Fatique in Cancer Patients Following External Beam Radiation Therapy |
|
|
Observational |
|
- National Institute of Nursing Research (NINR)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
|
26 |
Male |
18 Years to 100 Years (Adult, Senior) |
NCT01143467 |
100128
10-NR-0128 |
|
May 24, 2010 |
|
November 6, 2015 |
June 14, 2010 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 131 |
NCT00878150 |
Completed |
Life Improvement Following Traumatic Brain Injury |
- Traumatic Brain Injury
- Depression
|
- Behavioral: In-person Cognitive Behavioral Therapy
- Behavioral: Telephone Cognitive Behavioral Therapy
|
Interventional |
Not Applicable |
- University of Washington
- National Institutes of Health (NIH)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- U.S. Department of Education
|
Other / NIH / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hamilton Rating Scale for Depression (HAM-D)
- Symptom Checklist-20 (SCL-20)
- Patient Health Questionnaire-9 (PHQ-9)
- (and 7 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT00878150 |
40378 G
1R21HD053736-01A1
H133G070016 |
LIFT |
September 2007 |
December 2012 |
September 2013 |
April 8, 2009 |
October 18, 2013 |
|
- University of Washington School of Medicine
Seattle, Washington, United States
|
| 132 |
NCT02980484 |
Terminated |
fMRI-neuronavigated rTMS for the Treatment of Major Depression Associated With TBI |
- Major Depressive Disorder
- Traumatic Brain Injury
|
- Procedure: Active
- Procedure: Sham
|
Interventional |
Phase 2 |
- Washington University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement in depressive symptoms
- Changes in resting-state fMRI and DTI findings
- Changes in NIH Toolbox Cognitive, Emotional, and Quality of Life batteries
- (and 4 more...)
|
15 |
All |
18 Years to 65 Years (Adult) |
NCT02980484 |
201603051 |
|
August 2016 |
August 2017 |
August 2017 |
December 2, 2016 |
March 29, 2018 |
|
- Washington University School of Medicine
Saint Louis, Missouri, United States
|
| 133 |
NCT00029588 |
Completed |
Reward-Related Processes and Brain Function |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
|
241 |
All |
9 Years to 40 Years (Child, Adult) |
NCT00029588 |
020092
02-M-0092 |
|
January 11, 2002 |
|
July 24, 2017 |
January 16, 2002 |
October 6, 2017 |
|
- Childrens National Medical Center
Washington, D.C., District of Columbia, United States - National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 134 |
NCT01294332 |
Completed |
Effect of Aerobic Exercise Training on Cardiorespiratory Function in Patients With Traumatic Brain Injury |
- Exercise
- Fatigue
- Physical Fitness
- Traumatic Brain Injury
|
|
Interventional |
Phase 1
Phase 2 |
- National Institutes of Health Clinical Center (CC)
- Center for Neuroscience and Regenerative Medicine (CNRM)
- National Institutes of Health Clinical Center (CC)
|
NIH / U.S. Fed |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change in peak oxygen consumption
- Change in Fatigue
- Change in mood reactivity to exercise
|
13 |
All |
21 Years to 45 Years (Adult) |
NCT01294332 |
110088
11-CC-0088 |
|
May 26, 2011 |
December 31, 2013 |
February 11, 2014 |
February 11, 2011 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 135 |
NCT01296126 |
Completed |
Structural and Functional Neuroimaging Studies of Combat Veterans |
- Traumatic Brain Injury
- PTSD
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- Center for Neuroscience and Regenerative Medicine (CNRM)
- National Institutes of Health Clinical Center (CC)
|
NIH / U.S. Fed |
|
- Images from Magnetic Resonance Imaging, including structural, functional and DTI scans
- Results from the cognitive neuroscience experiments
|
81 |
All |
18 Years to 65 Years (Adult) |
NCT01296126 |
110090
11-N-0090 |
|
January 26, 2011 |
|
February 3, 2014 |
February 15, 2011 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 136 |
NCT00026832 |
Completed |
Examination of Brain Serotonin Receptors in Patients With Mood Disorders |
- Mood Disorder
- Bipolar Disorder
- Depression
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
214 |
All |
18 Years to 60 Years (Adult) |
NCT00026832 |
020047
02-M-0047 |
|
October 4, 2001 |
|
November 27, 2012 |
November 15, 2001 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 137 |
NCT02124057 |
Recruiting |
Study of Hepatic Function in Patients With Spinal and Bulbar Muscular Atrophy |
- Liver
- Motor Neuron Disease
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Liver MRI Spectroscopy
- Liver Ultrasound
- Blood testing, Livery Biopsy and Beck's Depression Inventory
|
75 |
All |
18 Years and older (Adult, Senior) |
NCT02124057 |
140099
14-N-0099 |
|
April 25, 2014 |
January 1, 2019 |
January 1, 2019 |
April 28, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 138 |
NCT01904032 |
Active, not recruiting |
Sunshine 2 Study for Women With Diabetes |
- Diabetes
- Depression
- Quality of Life
|
- Drug: Vitamin D3
- Drug: Vitamin D3 comparator
|
Interventional |
Phase 2 |
- Loyola University
- National Institutes of Health (NIH)
- National Institute of Nursing Research (NINR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Center for Epidemiologic Studies Depression (CES-D) score comparing Baseline (Month 0) to Month 6 for the experimental cohort versus active comparator cohort
- Problem Areas in Diabetes (PAIDS) score comparing Baseline (Month 0) to Month 6 for the experimental cohort versus active comparator cohort
- Diabetes Self-Care Inventory score comparing Baseline (Month 0) to Month 6 for the experimental cohort versus active comparator cohort
- Diabetes Self Efficacy Scale score comparing Baseline (Month 0) to Month 6 for the experimental cohort versus active comparator cohort
|
265 |
Female |
21 Years and older (Adult, Senior) |
NCT01904032 |
204197
1R01NR013906-01A1 |
|
November 21, 2013 |
June 2018 |
December 2018 |
July 22, 2013 |
January 9, 2018 |
|
- Loyola University Medical Center
Maywood, Illinois, United States
|
| 139 |
NCT00067496 |
Terminated |
Modafinil to Treat Fatigue in Post-Polio Syndrome |
- Postpoliomyelitis Syndrome
|
|
Interventional |
Phase 3 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
- Ascertain whether modafinil is of any benefit in alleviating the fatigue of Post-Polio Syndrome.
- Determine if fatigue reduction, correlates with improvement in quality of life of subjects with Post-Polio Syndrome. Investigate the pathophysiology of Post-Polio Syndrome by the study of serum and CSF for evidence of inflammatory markers.
|
30 |
All |
18 Years and older (Adult, Senior) |
NCT00067496 |
030276
03-N-0276 |
|
August 2003 |
|
August 2006 |
August 21, 2003 |
August 27, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
| 140 |
NCT00467090 |
Terminated |
Characteristics of Parkinson s Disease Associated With the LRRK-2 Gene Mutation |
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
|
34 |
All |
18 Years and older (Adult, Senior) |
NCT00467090 |
070137
07-N-0137 |
|
April 23, 2007 |
|
February 3, 2014 |
April 27, 2007 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 141 |
NCT01434368 |
Recruiting |
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty |
- Adolescent Developement
- Brain
- Developmental Biology
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- fMRI BOLD signal
- Behavioral Measures
- DTI
- UFC and wakening salivary cortisol
|
344 |
All |
8 Years to 35 Years (Child, Adult) |
NCT01434368 |
110251
11-M-0251 |
|
September 13, 2011 |
|
|
September 14, 2011 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 142 |
NCT03321214 |
Not yet recruiting |
Gluten Sensor Device to Promote Gluten Free Diet Adherence and Quality of Life in Patients With Celiac Disease |
|
- Device: Gluten Sensor Device
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Quality of life measure
- Depression
- Adherence to the gluten-free diet
- (and 2 more...)
|
30 |
All |
13 Years to 65 Years (Child, Adult) |
NCT03321214 |
AAAR6004 |
|
December 1, 2017 |
June 1, 2018 |
December 1, 2018 |
October 25, 2017 |
October 30, 2017 |
|
- Celiac Disease Center at Columbia University
New York, New York, United States
|
| 143 |
NCT00055575 |
Terminated |
Cholinergic Modulation of Condition and Emotion in Mood Disorders: Functional Neuroimaging Studies |
- Mood Disorders
- Healthy
- Unipolar Depression
- Bipolar Depression
|
- Drug: Transderm Scopolamine
|
Interventional |
Not Applicable |
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
- Evaluation of the antidepressant effects of the antimuscarinic agent scopolamine
|
197 |
All |
18 Years to 55 Years (Adult) |
NCT00055575 |
030108
03-M-0108 |
|
February 27, 2003 |
February 2, 2015 |
February 2, 2015 |
March 6, 2003 |
April 17, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 144 |
NCT01557543 |
Active, not recruiting |
Stem Cell Injection to Treat Heart Damage During Open Heart Surgery |
- Heart Disease
- Ischemic Heart Disease
- Coronary Artery Disease
- Coronary Artery Disease (CAD)
|
|
Interventional |
Phase 1 |
- National Heart, Lung, and Blood Institute (NHLBI)
- NIH Heart Center at Suburban Hospital
- National Institutes of Health Clinical Center (CC)
|
NIH / Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To evaluate the safety and feasibility of direct intra-myocardial injection of autologous bone marrow stromal cells (BMSCs) in adult subjects undergoing coronary artery bypass graft (CABG) or transmyocardial revascularization (TMR).
- To assess if direct intra-myocardial injection of autologous BMSCs improves the patient's cardiac function, quality of life, and reduces cardiac events compared to historical controls at three and six months after intervention.
|
24 |
All |
18 Years to 85 Years (Adult, Senior) |
NCT01557543 |
120078
12-H-0078 |
|
February 29, 2012 |
July 25, 2017 |
December 30, 2020 |
March 19, 2012 |
April 4, 2018 |
|
- Suburban Hospital
Bethesda, Maryland, United States - National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 145 |
NCT01018056 |
Completed
Has Results |
Developing New Treatments for Tourette Syndrome: Therapeutic Trials With Modulators of Glutamatergic Neurotransmission |
|
- Drug: D-serine
- Drug: Riluzole
- Drug: Placebo
|
Interventional |
Phase 4 |
- Johns Hopkins University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Change From Baseline to 6-week Scores for The Total Tic Subscale (TTS)
- The Change From Baseline to 6-week Scores for the Yale Global Tic Severity Scale (YGTSS) Total Score.
- The Change From Baseline to 6-week Score for the Clinical Global Impression -Improvement (CGI-I).
- (and 7 more...)
|
39 |
All |
8 Years to 17 Years (Child) |
NCT01018056 |
NA_00023969
R34MH085844 |
|
November 2009 |
September 2013 |
September 2013 |
November 23, 2009 |
January 30, 2018 |
July 1, 2014 |
- Johns Hopkins University
Baltimore, Maryland, United States
|
| 146 |
NCT03368469 |
Recruiting |
Transcranial Direct Current Stimulation (tDCS) in Children and Adolescents With Epilepsy and Depression |
- Depressive Disorder
- Generalized Epilepsy
|
- Device: transcranial direct current stimulation
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Children's Depression Rating Scale - Revised (CDRS-R) total score
- Quick Inventory of Depressive Symptoms - Adolescent - Self-Report (QIDS-A17-SR) total score
- tDCS Adverse Effects Survey
- (and 9 more...)
|
20 |
All |
10 Years to 21 Years (Child, Adult) |
NCT03368469 |
17-001007 |
|
February 23, 2018 |
December 2018 |
December 2018 |
December 11, 2017 |
February 26, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
| 147 |
NCT00166075 |
Completed |
Mental Health Symptoms and Intimate Partner Violence |
- Domestic Violence
- Post-Traumatic Stress Disorder
- Depression
|
- Procedure: Computer screen with community resource printout
|
Observational |
|
- Emory University
- National Institutes of Health (NIH)
- Centers for Disease Control and Prevention
|
Other / NIH / U.S. Fed |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Increased levels of PTSD
- Increased levels of suicidality
- Increased levels of depression
|
569 |
Female |
18 Years to 35 Years (Adult) |
NCT00166075 |
0304-2003a
5K23069375 |
|
January 2004 |
December 2006 |
December 2007 |
September 14, 2005 |
December 13, 2013 |
|
- Grady Memorial Hospital
Atlanta, Georgia, United States
|
| 148 |
NCT00073801 |
Completed |
Pelvic Pain in Women With Endometriosis |
- Endometriosis
- Pelvic Pain
- Healthy
- Tubal Ligation
|
|
Observational |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
78 |
Female |
18 Years to 50 Years (Adult) |
NCT00073801 |
040056
04-N-0056 |
|
December 8, 2003 |
|
|
December 9, 2003 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 149 |
NCT00753519 |
Completed
Has Results |
Transcranial Magnetic Stimulation to Treat Parkinson's Disease |
|
- Device: Real iTBS
- Device: Sham iTBS
|
Interventional |
Phase 1
Phase 2 |
- Mark Hallett
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Gait Speed
- Bradykinesia
- Total UPDRS Score
- Motor UPDRS
|
28 |
All |
40 Years to 80 Years (Adult, Senior) |
NCT00753519 |
080212
08-N-0212 |
|
September 2008 |
September 2009 |
September 2009 |
September 16, 2008 |
November 15, 2012 |
November 15, 2012 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
| 150 |
NCT01236586 |
Withdrawn |
RO4929097 in Children With Relapsed/Refractory Solid or CNS Tumors, Lymphoma, or T-Cell Leukemia |
- Lymphoma
- Brain Neoplasms
- Sarcoma
- (and 2 more...)
|
- Drug: RO4929097
- Drug: Dexamethasone
|
Interventional |
Phase 1 |
- National Cancer Institute (NCI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary outcomes of this study are self-reported fatigue, depression, and quality of life scores of patients before, at midpoint, and at completion of each cycle of their cancer treatment.
- Cytokine profile
|
0 |
All |
1 Year to 21 Years (Child, Adult) |
NCT01236586 |
110017
11-C-0017 |
|
October 8, 2010 |
April 13, 2011 |
April 13, 2011 |
November 8, 2010 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - St. Jude Childrens Research Hospital
Memphis, Tennessee, United States
|
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