| 1 |
NCT02237846 |
Withdrawn |
Clinical Study of Umbilical Cord Tissue Mesenchymal Stem Cells (UC-MSC) for Treatment of Osteoarthritis |
- Osteoarthritis of the Knee
|
- Biological: Human umbilical cord tissue-derived mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Number of participants with a change in joint function from baseline WOMAC assessment
- Number of participants with a change in radiogrpahic evidence of knee OA from baseline Kellegren-Lawrence grading system
|
0 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02237846 |
CNEI-2014-TBS-UCMSCOA-001 |
|
September 2014 |
November 2018 |
August 2019 |
September 11, 2014 |
August 10, 2017 |
|
- Stem Cell Instsitute
Panama City, Panama
|
|
| 2 |
NCT01985464 |
Recruiting |
Umbilical Cord Tissue-derived Mesenchymal Stem Cells for Rheumatoid Arthritis |
|
- Biological: Umbilical cord mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Number of participants with a change in disease activity index as measured by 28-DAS Score
- Number of participants with a change in current disease activity as measured by EULAR Response Criteria
- (and 5 more...)
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT01985464 |
TBS-UCMSCRA-001 |
|
October 2013 |
December 2019 |
June 2020 |
November 15, 2013 |
October 19, 2018 |
|
- Stem Cell Institute
Panama City, Panama
|
|
| 3 |
NCT02034188 |
Completed |
Feasibility Study of Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells in Patients With Multiple Sclerosis |
|
- Biological: Umbilical cord mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Number of participants with a change in disability as measured by Expanded Disability Status Scale (EDSS)
- Number of participants with a change in neurological impairment as measured by Scripps Neurological Rating Scale
- (and 6 more...)
|
20 |
All |
18 Years to 55 Years (Adult) |
NCT02034188 |
TBS-UCMSC-001 |
|
January 2014 |
March 2016 |
March 2016 |
January 13, 2014 |
August 10, 2017 |
|
- Stem Cell Institute
Panama City, Panama
|
|
| 4 |
NCT03818737 |
Not yet recruiting
New |
Multicenter Trial of Stem Cell Therapy for Osteoarthritis (MILES) |
|
- Biological: Autologous Bone Marrow Concentrate (BMAC)
- Biological: Adipose-derived Stromal Vascular Fraction (SVF)
- Biological: Umbilical Cord Tissue (UCT)
- Drug: Depomedrol and Normal saline (Corticosteroid injection)
|
Interventional
|
Phase 3 |
- Emory University
- The Marcus Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in Visual Analog Pain Scale (VAS-pain) scores
- Change in Knee Injury and Osteoarthritis Outcome Score (KOOS)
- Change in EuroQuality of Life (EQ5D-3L) scores
- Change in Patient-Reported Outcomes Measurement Information System (PROMIS 29) scores
|
480 |
All |
40 Years to 70 Years (Adult, Older Adult) |
NCT03818737 |
IRB00108046 |
MILES |
March 25, 2019 |
December 31, 2021 |
December 31, 2021 |
January 28, 2019 |
January 29, 2019 |
|
- Andrews Institute
Gulf Breeze, Florida, United States - The Emory Clinic
Atlanta, Georgia, United States - Duke University
Durham, North Carolina, United States - (and 2 more...)
|
|
| 5 |
NCT02587715 |
Unknown † |
A Study of Allogeneic Human UC-MSC and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS |
- Multiple Sclerosis, Relapsing-Remitting
|
- Biological: Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells
- Other: Liberation therapy
|
Interventional
|
Phase 1
Phase 2 |
- Novo Cellular Medicine Institute LLP
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients with clinical improvement in EDSS score compared to baseline
- Proportion of patients with a change in either gadolinium enhancing or new T2-weighted lesions on brain MRI
- Proportion of patients with reduction in T2 lesion volume on brain MRI
- (and 7 more...)
|
69 |
All |
18 Years to 60 Years (Adult) |
NCT02587715 |
PRT/NOVO/2015/001 |
|
February 2015 |
February 2017 |
February 2017 |
October 27, 2015 |
October 28, 2015 |
|
- Novo Cellular Medicine Institute
San Fernando, Trinidad, Trinidad and Tobago
|
|
| 6 |
NCT02418325 |
Terminated |
A Study of Allogeneic Human UC-MSC and Liberation Therapy (When Associated With CCSVI) in Patients With RRMS |
- Multiple Sclerosis, Relapsing-Remitting
|
- Biological: Allogeneic Human Umbilical Cord Tissue-Derived Mesenchymal Stem Cells
- Other: Liberation therapy
|
Interventional
|
Phase 1
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients with clinical improvement in EDSS score compared to baseline
- Proportion of patients with a change in either gadolinium enhancing or new T2-weighted lesions on brain MRI
- Proportion of patients with reduction in T2 lesion volume on brain MRI
- (and 7 more...)
|
69 |
All |
18 Years to 60 Years (Adult) |
NCT02418325 |
PRT/GENESIS/2015/001 |
|
February 2015 |
February 2017 |
February 2017 |
April 16, 2015 |
November 4, 2015 |
|
- Genesis Institute of Cellular Medicine, Genesis (Trinidad and Tobago) Private Limited
San Fernando, Trinidad, Trinidad and Tobago
|
|
| 7 |
NCT03473301 |
Active, not recruiting |
A Study of UCB and MSCs in Children With CP: ACCeNT-CP |
|
- Biological: Infusion of allogeneic umbilical cord blood
- Biological: Infusion of MSCs
|
Interventional
|
Phase 1
Phase 2 |
- Joanne Kurtzberg, MD
- The Marcus Foundation
- Duke University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- GMFM-66 score 12 months after study infusion
- Adverse events
|
90 |
All |
24 Months to 60 Months (Child) |
NCT03473301 |
Pro00089362 |
ACCeNT-CP |
April 9, 2018 |
May 2020 |
May 2021 |
March 22, 2018 |
February 15, 2019 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
|
| 8 |
NCT02192749 |
Completed |
Allogeneic Umbilical Cord Mesenchymal Stem Cell Therapy for Autism |
|
- Biological: Umbilical cord mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Number of participants with a change in disability as measured by the Autism Treatment Evaluation Checklist (ATEC)
- Number of participants with a change in disability as measured by the Childhood Autism Rating Scale (CARS)
- (and 2 more...)
|
20 |
All |
6 Years to 16 Years (Child) |
NCT02192749 |
TBS-UCMSC-ASD001 |
|
July 2014 |
August 2017 |
August 2017 |
July 17, 2014 |
October 13, 2017 |
|
- Stem Cell Institute
Panama City, Panama
|
|
| 9 |
NCT03828344 |
Not yet recruiting
New |
Safety and Tolerability of a Single Intravenous Infusion of BX-U001 in Refractory Rheumatoid Arthritis |
|
- Biological: hUC-MSC suspension
- Biological: Placebo
|
Interventional
|
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Frequency of Adverse Events (AE) and Serious Adverse Events (SAE)
- Percentage of participants achieving ACR20 from Baseline at Week 12 and Week 24
- Percentage of participants achieving ACR50 response from Baseline at Week 12 and Week 24
- (and 6 more...)
|
16 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03828344 |
BXU001-RA |
|
October 2019 |
September 2021 |
September 2021 |
February 4, 2019 |
February 4, 2019 |
|
|
|
| 10 |
NCT02237547 |
Withdrawn |
Safety and Feasibility Study of Cell Therapy in Treatment of Spinal Cord Injury |
|
- Biological: Intravenous and intrathecal human umbilical cord tissue-derived mesenchymal stem cells and bone marrow mononuclear cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients with adverse events
- Number of subjects with a change in American Spinal Injury Association (ASIA) score from baseline
- Number of subjects with a change in Frankel Scale score from baseline
|
0 |
All |
18 Years to 50 Years (Adult) |
NCT02237547 |
CNEI-2014-TBS-UCMSC-SCI001 |
|
September 2014 |
January 2019 |
October 2019 |
September 11, 2014 |
August 10, 2017 |
|
- Stem Cell Institute
Panama City, Panama
|
|
| 11 |
NCT03059355 |
Recruiting |
Infusion of Umbilical Cord Versus Bone Marrow Derived Mesenchymal Stem Cells to Evaluate Cytokine Suppression. |
- Endothelial Dysfunction
- Metabolic Syndrome
- Chronic Inflammation
|
- Biological: UCMSCs
- Biological: BMMSCs
- Other: Placebo
|
Interventional
|
Phase 1
Phase 2 |
- Joshua M Hare
- University of Miami
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of any treatment-emergent serious adverse events (TE-SAEs)
- Change of inflammatory markers
- Effect on Frailty Phenotype Score
- (and 4 more...)
|
37 |
All |
21 Years to 95 Years (Adult, Older Adult) |
NCT03059355 |
20170095 |
CERES |
April 12, 2018 |
June 2025 |
June 2026 |
February 23, 2017 |
February 22, 2019 |
|
- ISCI / University of Miami Miller School of Medicine
Miami, Florida, United States
|
|
| 12 |
NCT03099239 |
Active, not recruiting |
hCT-MSCs for Children With Autism Spectrum Disorder (ASD) |
- Autism
- Autism Spectrum Disorder
- ASD
|
- Biological: hCT-MSC infusion
|
Interventional
|
Phase 1 |
- Joanne Kurtzberg, MD
- The Marcus Foundation
- Duke University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of Infusion reactions
- Incidence of Infections
|
12 |
All |
2 Years to 11 Years (Child) |
NCT03099239 |
Pro00079421 |
hCT-MSCs |
June 6, 2017 |
February 28, 2019 |
February 28, 2019 |
April 4, 2017 |
February 6, 2019 |
|
- Duke University Medical Center
Durham, North Carolina, United States
|
|
| 13 |
NCT03484741 |
Recruiting |
Mesenchymal Stem Cell Therapy for Type 1 Diabetes Mellitus Patients |
|
|
Interventional
|
Phase 1
Phase 2 |
- Van Hanh General Hospital
- University of Science Ho Chi Minh City
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Fasting blood glucose
- Hemoglobin A1c (HbA1c) level
- Adverse events
- (and 3 more...)
|
15 |
All |
18 Years to 45 Years (Adult) |
NCT03484741 |
DIME 1001 |
|
April 1, 2017 |
November 2018 |
November 2018 |
April 2, 2018 |
April 4, 2018 |
|
- Van Hanh Geral Hospital
Ho Chi Minh City, Ho Chi Minh, Vietnam
|
|
| 14 |
NCT03635450 |
Recruiting |
Study of hCT-MSC in Newborn Infants With Moderate or Severe HIE |
- Moderate to Severe Hypoxic-ischemic Encephalopathy
|
- Biological: Infusion of hCT-MSC
|
Interventional
|
Phase 1 |
- Joanne Kurtzberg, MD
- The Duke Clinical and Translational Science Institute (CTSI), part of the National Institutes of Health's Clinical and Translational Science Awards (CTSA)
- Duke University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of infusion reactions
- Incidence of Infections post-infusion
- Survival
- Neurodevelopmental Assessments
|
6 |
All |
up to 48 Hours (Child) |
NCT03635450 |
Pro00100253 |
|
December 27, 2018 |
November 1, 2020 |
March 1, 2021 |
August 17, 2018 |
January 4, 2019 |
|
- Duke University
Durham, North Carolina, United States
|
|
| 15 |
NCT03838146 |
Recruiting
New |
Influence of Maternal Exercise on Infant Skeletal Muscle and Metabolomics |
|
- Behavioral: Types of Exercise
|
Interventional
|
Not Applicable |
- East Carolina University
- American Heart Association
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Human Skeletal Muscles cells grown from MSCs will have insulin responsiveness measured
- Global and targeted metabolomics analysis will be conducted to map out pathways and mechanisms from regular maternal exercise. Docosahexaenoic acid (DHA), Eicosapentaenoic Acid (EPA), Docosapentaenoic Acid (DPA), and Arachidonic acid (ARA).
- Peabody Developmental Motor Scales, 2nd edition (PDMS-2) will be performed by a pediatric physical therapist (blinded to group classification) to measure gross motor skills of infants up to 12 months of age.
- (and 2 more...)
|
160 |
Female |
18 Years to 35 Years (Adult) |
NCT03838146 |
12-002524b |
|
September 1, 2018 |
August 30, 2020 |
August 30, 2021 |
February 12, 2019 |
February 12, 2019 |
|
- East Carolina University
Greenville, North Carolina, United States
|
|
| 16 |
NCT03230175 |
Active, not recruiting |
Phase 2 Pilot Trial of Subjects With Complex Non-healing Diabetic Foot Ulcers Treated With Standard Care Plus Cryopreserved Umbilical Cord Allograft (TTAX01) |
- Non-healing Wound
- Non-healing Diabetic Foot Ulcer
- Diabetic Foot Infection
|
|
Interventional
|
Phase 2 |
- Tissue Tech Inc.
- Tissue Tech Inc.
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete wound healing
- Time to complete wound healing
- Rate of wound closure (area)
- (and 6 more...)
|
32 |
All |
18 Years and older (Adult, Older Adult) |
NCT03230175 |
TTCRNE-1501 |
|
October 4, 2017 |
January 2019 |
March 2019 |
July 26, 2017 |
January 25, 2019 |
|
- Banner University Medical Center
Phoenix, Arizona, United States - UCLA Olive View
Sylmar, California, United States - University of Miami
Miami, Florida, United States - (and 8 more...)
|
|
| 17 |
NCT02192736 |
Active, not recruiting |
Safety and Feasibility Study of Intranasal Mesenchymal Trophic Factor (MTF) for Treatment of Asthma |
|
- Biological: Trophic factors from umbilical cord mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of patients with adverse events
- Number of patients with a change in pulmonary function from baseline as measured by Forced Expiratory Volume (FEV1) following American Thoracic Society (ATS) guidelines
- Number of patients with a change in pulmonary function from baseline as measured by Forced Vital Capacity (FVC) following American Thoracic Society (ATS) guidelines
- Number of patients with a change in quality of life from baseline as measured by the University of Pittsburgh Medical Center (UPMC) Asthma Questionnaire
|
20 |
All |
21 Years to 60 Years (Adult) |
NCT02192736 |
TBS-MTFAS-001 |
|
July 2014 |
April 2020 |
October 2020 |
July 17, 2014 |
June 26, 2018 |
|
- Punta Pacifica Hospital
Panama City, Panama
|
|
| 18 |
NCT02003131 |
Withdrawn |
Safety and Feasibility Study of Mesenchymal Trophic Factor (MTF) for Treatment of Osteoarthritis |
- Osteoarthritis of the Knee
|
- Biological: Trophic factors from umbilical cord mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Translational Biosciences
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of participants with adverse events
- Number of participants with a change in joint function from baseline WOMAC assessment at 12 months
- Number of participants with a change in radiogrpahic evidence of knee OA from baseline Kellegren-Lawrence grading system at 12 months
|
0 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02003131 |
TBS-MTFOA-001 |
|
December 2013 |
December 2018 |
June 2019 |
December 6, 2013 |
August 10, 2017 |
|
- Stem Cell Institute
Panama City, Panama
|
|
| 19 |
NCT03818828 |
Recruiting
New |
Subjects With Non-Healing Venous Leg Ulcers Treated With Standard Care Plus Cryopreserved Human Umbilical Cord (TTAX01) |
|
|
Interventional
|
Phase 2 |
- Tissue Tech Inc.
- Tissue Tech Inc.
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete wound healing
- Time to complete wound healing
- Changes in pain using the numeric rating scale
|
35 |
All |
18 Years and older (Adult, Older Adult) |
NCT03818828 |
TTAX01-CR002 |
|
February 14, 2019 |
December 2019 |
February 2020 |
January 28, 2019 |
February 22, 2019 |
|
- ILD Consulting, Inc.
Carlsbad, California, United States - UCLA Olive View
Sylmar, California, United States - Rosalind Franklin University
North Chicago, Illinois, United States - (and 3 more...)
|
|
| 20 |
NCT03631420 |
Not yet recruiting |
Mesenchymal Stem Cells for The Treatment of Bronchopulmonary Dysplasia in Infants |
- Bronchopulmonary Dysplasia
|
- Biological: Human Umbilical Cord Derived-Mesenchymal Stem Cells
|
Interventional
|
Phase 1 |
- Meridigen Biotech Co., Ltd.
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The incidence and frequency of adverse events related to administration of UMC119-01.
- The percentage of subjects who died from any cause during the study.
- Changes of the oxygen saturation.
- (and 4 more...)
|
9 |
All |
36 Weeks to 38 Weeks (Child) |
NCT03631420 |
UMC119-01-001 |
|
October 1, 2018 |
October 31, 2020 |
October 31, 2022 |
August 15, 2018 |
August 15, 2018 |
|
- National Chen-Kung University Hospital
Tainan City, Taiwan
|
|
| 21 |
NCT01166776 |
Completed |
A Research Study Looking at Specific Tissue of the Umbilical Cord |
- Varices of Umbilical Cord
|
|
Observational
|
|
- University of Kansas Medical Center
- Children's Mercy Hospital Kansas City
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Isolation and decellularization of umbilical cord Wharton's jelly matrix
- Study the ability of the isolated and decellularized matrix to support recellularization with mesenchymal stem cells and to support their growth and differentiation
|
64 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01166776 |
12129 |
|
June 2010 |
April 2016 |
July 2016 |
July 21, 2010 |
August 22, 2016 |
|
- University of Kansas Medical Center
Kansas City, Kansas, United States - Children's Mercy Hospital
Kansas City, Missouri, United States
|
|
| 22 |
NCT02384785 |
Unknown † |
Effectiveness of of Therapeutic Currents in Clinical Dimension and Penetration Depth Dimension in Lower Back |
|
- Device: Transcutaneous Electric Nerve Stimulation
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The amount of electric voltage
|
25 |
All |
21 Years to 75 Years (Adult, Older Adult) |
NCT02384785 |
SHEBA-12-9941-IGA-CTIL |
|
May 2013 |
December 2017 |
December 2017 |
March 10, 2015 |
April 28, 2017 |
|
- Sheba Medical Center
Tel Hashomer, Israel
|
|
| 23 |
NCT03406585 |
Recruiting |
Wharton´s Jelly Derived Mesenchymal Stromal Cell Treatment of Adult Patients Diagnosed With Type I Diabetes |
|
- Drug: ProTrans: Allogeneic transplantation with WJMSCs
- Drug: Placebos
|
Interventional
|
Phase 1
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Safety; measured through set safety parameters
- Efficacy; comparison of the intervention versus placebo at day 372 versus start of treatment
- Number of patients insulin independent (ADA criteria) at days 187 and 372
- (and 6 more...)
|
24 |
All |
18 Years to 40 Years (Adult) |
NCT03406585 |
ProTrans-T1D
2017-002766-50 |
|
November 28, 2017 |
June 1, 2020 |
June 1, 2020 |
January 23, 2018 |
January 30, 2018 |
|
- Karolinska Trial Alliance, Fas 1 enheten, Karolinska Universitetssjukhuset Huddinge
Stockholm, Sweden
|
|
| 24 |
NCT01556867 |
Terminated |
Evaluation of Two Strategies for Umbilical Cord Care : Dry Cord Care Versus Antiseptic on the Incidence of Omphalitis in Healthy Term Newborn |
|
- Other: Cord care by simple debridement (soaping, rinsing and drying)
- Other: Cord care with the use of antiseptics
|
Interventional
|
Not Applicable |
- Nantes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- The incidence of occurrence of omphalitis within 28 days post-birth in omphalitis incidence in healthy newborn
- Occurrence of neonatal infection defined as any situation requiring hospitalization and antibiotics in the first month of life
- Date of the fall of the umbilical cord
- (and 6 more...)
|
8698 |
All |
up to 24 Hours (Child) |
NCT01556867 |
BRD/10/06-U |
NEOCORD |
March 2011 |
March 2012 |
March 2012 |
March 16, 2012 |
August 8, 2016 |
|
- Dr SAVAGNER Christophe
Angers, France - Dr GREMMO-FREGER Gisèle
Brest, France - Dr GRAS-LEGUEN
Nantes, France - (and 3 more...)
|
|
| 25 |
NCT02211651 |
Completed |
Maternal Adipose Tissue and Placental Dysfunction Programs the Fetus for Type 2 Diabetes (PlacentA-DM) |
|
|
Observational
|
|
- Translational Research Institute for Metabolism and Diabetes, Florida
- Sanford-Burnham Medical Research Institute
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Quantity of Blood Vessels and Capillaries
- Quantity of macrophages
|
3 |
Female |
18 Years to 40 Years (Adult) |
NCT02211651 |
TRIMDFH 499458
499458 |
PlacentA-DM |
December 2013 |
December 2016 |
January 2017 |
August 7, 2014 |
April 25, 2018 |
|
- Translational Research Institute for Metabolism and Diabetes
Orlando, Florida, United States
|
|
| 26 |
NCT00701350 |
Completed |
Biomarkers of Intra-amniotic Infection in Women With Preterm Premature Ruptured Amniotic Membranes |
- Intra-amniotic Infection
- Preterm Birth
|
|
Observational
|
|
- ProteoGenix, Inc.
- Obstetrix Medical Group
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Expression of protein biomarkers in cervial vaginal fluid
|
79 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00701350 |
PGX03-OBX0009 |
PPROM |
June 2008 |
February 2010 |
February 2010 |
June 19, 2008 |
July 21, 2010 |
|
- Banner Good Samaritan Hospital
Phoenix, Arizona, United States - Tucson Medical Center
Tucson, Arizona, United States - Good Samaritan Hospital
San Jose, California, United States - Presbyterian St. Luke's Medical Center
Denver, Colorado, United States
|
|
| 27 |
NCT00700219 |
Unknown † |
Non-invasive Test to Detect Intra-amniotic Infection in Women With Preterm Labor and Intact Amniotic Membranes |
|
|
Observational
|
|
- ProteoGenix, Inc.
- Obstetrix Medical Group
|
Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Performance of immunoassay panel to detect intra-amniotic infection in target population.
|
900 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00700219 |
PGX01-OBX0006 |
IAI |
June 2008 |
September 2010 |
September 2010 |
June 18, 2008 |
July 21, 2010 |
|
- Banner Desert Memorial Medical Center
Mesa, Arizona, United States - Banner Good Samaritan Hospital
Phoenix, Arizona, United States - Tucson Medical Center
Tucson, Arizona, United States - (and 18 more...)
|
|
| 28 |
NCT00821132 |
Recruiting |
Genetics of Familial and Sporadic ALS |
- Amyotrophic Lateral Sclerosis (ALS)
- Familial Amyotrophic Lateral Sclerosis
- Amyotrophic Lateral Sclerosis With Frontotemporal Dementia
- (and 3 more...)
|
- Other: Genetic study of ALS families
|
Observational
|
|
|
Other |
- Observational Model: Family-Based
- Time Perspective: Other
|
- Identification of genes that increase risk for sporadic ALS or cause inherited ALS.
|
15000 |
All |
18 Years and older (Adult, Older Adult) |
NCT00821132 |
Lab01
RO1N505641-04 |
ALS |
January 1991 |
December 2019 |
December 2022 |
January 13, 2009 |
March 29, 2018 |
|
- Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
|
|
| 29 |
NCT00330447 |
Recruiting |
Effects of Oncological Treatment During Pregnancy on Mother and Child |
|
|
Observational
|
|
- University Hospital, Gasthuisberg
- Laurence Claes, PhD
- Ingrid Boere, MD PhD
- (and 8 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Follow-up of the mothers diagnosed with cancer during pregnancy
- Follow-up of the children antenatally exposed to chemotherapy or radiotherapy
|
5000 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00330447 |
cancer in pregnancy |
|
August 2005 |
April 2025 |
December 2032 |
May 26, 2006 |
May 22, 2018 |
|
- UCL Brussels
Brussels, Belgium - UZ Gasthuisberg, Katholieke Universiteit Leuven
Leuven, Belgium - Regional Hospital of High Specialty of Ixtapaluca
Ixtapaluca, Mexico - (and 2 more...)
|
|
| 30 |
NCT01769872 |
Completed |
Safety and Effect of Adipose Tissue Derived Mesenchymal Stem Cell Implantation in Patients With Spinal Cord Injury |
|
- Procedure: Autologous Adipose Tissue derived MSCs Transplantation
|
Interventional
|
Phase 1
Phase 2 |
- Biostar
- Korea University Anam Hospital
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- ASIA (American Spinal Injury Association) scale
- Magnetic Resonance Imaging
- MEP/SSEP
- (and 4 more...)
|
15 |
All |
19 Years to 70 Years (Adult, Older Adult) |
NCT01769872 |
KSC-MSCs-SPI |
|
January 2013 |
January 2016 |
|
January 17, 2013 |
August 2, 2016 |
|
- Korea University Anam Hospital
Seoul, Korea, Republic of
|
|
| 31 |
NCT01624779 |
Completed |
Intrathecal Transplantation Of Autologous Adipose Tissue Derived MSC in the Patients With Spinal Cord Injury |
|
- Drug: autologous adipose tissue derived mesenchymal stem cells
|
Interventional
|
Phase 1 |
|
Industry |
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Significant MRI Change before and after intervention
- Significant neurologic funtion Change before and after intervention
- Significant Electrophysiological Change before and after intervention
- Adverse event
|
15 |
All |
19 Years to 70 Years (Adult, Older Adult) |
NCT01624779 |
KOR-01 |
|
April 2012 |
May 2014 |
May 2014 |
June 21, 2012 |
February 13, 2015 |
|
- Korea University Anam Hospital
Seoul, Seongbukgu, Korea, Republic of
|
|
| 32 |
NCT03167138 |
Recruiting |
Micro-Fragmented Adipose Tissue (Lipogems®) Injection for Chronic Shoulder Pain in Persons With Spinal Cord Injury |
- Shoulder Pain
- Shoulder Impingement Syndrome
- Rotator Cuff Impingement Syndrome
- (and 3 more...)
|
- Biological: Autologous micro-fragmented adipose tissue
- Device: Lipogems system
|
Interventional
|
Early Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Numerical Rating Scale
- Wheelchair User's Shoulder Pain Index (WUSPI)
- Patient Global Impression of Change
- (and 2 more...)
|
12 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03167138 |
R-957-17 |
|
July 14, 2017 |
December 30, 2019 |
December 30, 2019 |
May 25, 2017 |
August 8, 2018 |
|
- Kessler Institute for Rehabilitation
West Orange, New Jersey, United States
|
|
| 33 |
NCT00938600 |
Completed |
Antenatal Vitamin D3 Dose-finding and Safety Study |
- Pregnancy
- Nutritional Status
- Vitamin D
|
- Dietary Supplement: Vitamin D3
|
Interventional
|
Phase 1 |
- Johns Hopkins Bloomberg School of Public Health
- Johns Hopkins University
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- 25-hydroxyvitamin D concentration
- Serum calcium concentration (albumin-corrected)
- Urine calcium: creatinine ratio
- (and 6 more...)
|
75 |
Female |
18 Years to 34 Years (Adult) |
NCT00938600 |
JHU-1819 |
AViDD-1 |
July 2009 |
June 2010 |
June 2010 |
July 14, 2009 |
August 17, 2012 |
|
- SHIMANTIK Maternity Centre
Dhaka, Bangladesh
|
|
| 34 |
NCT00362089 |
Completed |
Fatty Acids During Pregnancy and Lactation and Body Fat Mass in Newborns |
|
- Dietary Supplement: Marinol D-40
|
Interventional
|
Not Applicable |
- Technische Universität München
- Else Kröner-Fresenius-Foundation; International Unilever-Foundation; Danone Research
- EU funding by EARNEST consortium;German Ministry of Education and Research GF-GFGI01120708)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- amount of fat mass in the offspring
- offspring body height
- head circumference of newborns, infants and children
- (and 19 more...)
|
208 |
Female |
18 Years to 43 Years (Adult) |
NCT00362089 |
EKFZ001_CN
INFAT |
|
June 2006 |
November 2010 |
November 2010 |
August 9, 2006 |
February 4, 2014 |
|
- Else Kröner-Fresenius-Zentrum für Ernährungsmedizin, Technische Universität München
Munich, Germany
|
|
| 35 |
NCT03113786 |
Active, not recruiting |
CLARIX™ 100 & CLARIX CORD 1K for Discectomy Patients |
|
- Biological: CLARIX™100
- Biological: CLARIX CORD 1K
|
Interventional
|
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Difference in low back & leg pain
|
120 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT03113786 |
CR-1001 |
|
November 2, 2011 |
March 21, 2018 |
March 2020 |
April 14, 2017 |
October 12, 2018 |
|
- Rothman Institute
Bensalem, Pennsylvania, United States
|
|
| 36 |
NCT03317288 |
Recruiting |
Alternating Pressure Overlay on Weight Bearing Tissue Tolerance in People With Spinal Cord Injury |
- Spinal Cord Injuries
- Pressure Ulcer
|
- Device: Dabir Air overlay
|
Interventional
|
Not Applicable |
- University of Illinois at Chicago
- Dabir Surfaces Inc
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Skin blood flow, laser Doppler flowmetry
- Heat hyperemic blood flow, laser Doppler flowmetry
- Skin vasomotor response
- Pressure map
|
20 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03317288 |
2017-0215 |
|
May 12, 2017 |
June 1, 2019 |
June 1, 2019 |
October 23, 2017 |
November 12, 2018 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States
|
|
| 37 |
NCT02509988 |
Active, not recruiting |
Nutritional Intervention Preconception and During Pregnancy to Maintain Healthy Glucose Metabolism and Offspring Health |
|
- Dietary Supplement: Study nutritional drink
- Dietary Supplement: Standard nutritional drink
|
Interventional
|
Not Applicable |
- University of Southampton
- National University Hospital, Singapore
- Auckland UniServices Ltd.
- (and 3 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Glucose tolerance during pregnancy
- Duration of gestation
- Pregnancy weight gain and body composition
- (and 42 more...)
|
1729 |
Female |
18 Years to 38 Years (Adult) |
NCT02509988 |
13597
34104
2015/00205
U1111-1171-8056 |
NiPPeR |
July 2015 |
October 2018 |
March 2021 |
July 28, 2015 |
January 11, 2019 |
|
- The University of Auckland
Auckland, New Zealand - National University Hospital
Singapore, Singapore - University Hospital Southampton NHS Foundation Trust
Southampton, Hampshire, United Kingdom
|
|
| 38 |
NCT02904824 |
Completed |
Injection Laryngoplasty Using Autologous Fat Enriched With Adipose Derived Regenerative Stem Cells (ADRC) |
- Vocal Cord Paralysis, Unilateral
|
- Biological: adipose derived regenerative cells
- Biological: centrifuged autologous fat
|
Interventional
|
Phase 1
Phase 2 |
- Hospital General Universitario Gregorio Marañon
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of Treatment-Emergent Adverse Events
- Assessment of vocal cord volume and gap closure by direct laryngoscopy and Biometphone device to study vocal cord parameters
|
16 |
All |
18 Years and older (Adult, Older Adult) |
NCT02904824 |
FIBHGM-ECNC007-2010 |
|
July 2012 |
September 2014 |
July 2015 |
September 19, 2016 |
September 19, 2016 |
|
- Jose M Lasso
Madrid, Spain
|
|
| 39 |
NCT02391519 |
Recruiting |
Effects of High Altitude on AMPK Activation |
- Pregnancy
- IUGR
- Preeclampsia
|
- Procedure: Collection of myometrial, cord blood, and placental tissue samples
|
Observational
|
|
- University of Colorado, Denver
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Changes in Myometrial artery dimensions
|
84 |
Female |
18 Years to 45 Years (Adult) |
NCT02391519 |
14-2178 |
|
January 2016 |
April 2019 |
June 2019 |
March 18, 2015 |
December 21, 2018 |
|
- University of Colorado Denver Anschutz Medical Campus
Aurora, Colorado, United States
|
|
| 40 |
NCT00266864 |
Completed
Has Results |
Testosterone Replacement Therapy in Chronic Spinal Cord Injury |
- Spinal Cord Injury
- Hypogonadism
|
- Drug: Testosterone Transdermal System (Androderm 5 mg patch)
|
Interventional
|
Phase 2
Phase 3 |
- VA Office of Research and Development
- Kessler Institute for Rehabilitation
|
U.S. Fed / Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Dual Energy X-ray Absorptiometry (DXA) Assessment of Lean Tissue Mass (LTM)
- Resting Energy Expenditure
|
31 |
Male |
18 Years to 49 Years (Adult) |
NCT00266864 |
B2648-C |
|
August 2003 |
August 2012 |
December 2012 |
December 19, 2005 |
November 1, 2017 |
April 7, 2014 |
- Kessler Institute for Rehabilitation
West Orange, New Jersey, United States - James J. Peters VA Medical Center
The Bronx, New York, United States
|
|
| 41 |
NCT02754284 |
Recruiting |
Clinical Study of Regeneration on Larynx Soft Tissue Guided by Functional Collagen Scaffold |
|
- Biological: Autologous fat transplantation
- Biological: Functional collagen scaffold transplantation
|
Interventional
|
Phase 1 |
- Chinese Academy of Sciences
- Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change in subjective auditory perception score
- Change in voice handicap index (VHI) scale
- Objective acoustic evaluation (Jitter)
- (and 7 more...)
|
10 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02754284 |
CAS-XDA-LST/IGDB |
|
December 2015 |
June 2020 |
June 2020 |
April 28, 2016 |
July 16, 2018 |
|
- Peking Union Medical College Hospital, Chinese Academy of Medical Sciences
Beijing, China
|
|
| 42 |
NCT02925364 |
Recruiting |
Functional and Anatomical MRI of the Spinal Cord and Peri-spinal Tissues |
- Chronic Pain
- Other Functional Disturbances Following Cardiac Surgery
|
- Radiation: magnetic resonance imaging (MRI)
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- functional MRI (fMRI)
- anatomical MRI
|
30 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02925364 |
ANAE-233-13-amendment |
|
September 2016 |
December 2018 |
December 2018 |
October 5, 2016 |
April 11, 2018 |
|
- Kingston General Hospital
Kingston, Ontario, Canada
|
|
| 43 |
NCT02507817 |
Unknown † |
Correlation Between LIF (Leukemia Inhibitory Factor ) Levels in Cord and Maternal Blood in Women Treated With Mg |
- LIF LEVELS IN CORD BLOOD AND MATERNAL BLOOD DURING LABOR
|
- Other: blood sample and tissue sample
|
Observational
|
|
- Rambam Health Care Campus
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Correlation between LIF Levels in women who where treated with Mg and women who where not (maternal LIF levels prior to birth and Maternal and cord levels after delivery)
|
100 |
Female |
16 Years to 45 Years (Child, Adult) |
NCT02507817 |
0604-14-RMB CTIL |
|
August 2015 |
June 2017 |
June 2017 |
July 24, 2015 |
August 7, 2015 |
|
|
|
| 44 |
NCT00262457 |
Withdrawn |
BIONs, for Improved Tissue Health and Pressure Sore Prevention |
- Pressure Ulcers
- Spinal Cord Injury
|
- Device: Implanted gluteal electrical stimulation system
|
Interventional
|
Not Applicable |
- US Department of Veterans Affairs
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement of tissue health
|
0 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00262457 |
B3259-R |
|
April 2004 |
February 2008 |
February 2008 |
December 6, 2005 |
September 17, 2013 |
|
- VA Medical Center, Cleveland
Cleveland, Ohio, United States
|
|
| 45 |
NCT01771159 |
Not yet recruiting |
Tissue Bonding Cystostomy(TBC) |
- Spinal Cord Injury (SCI)
- Chronic Urinary Retention
- Urinary Incontinence
|
|
Interventional
|
Phase 1 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Continuous use
- Chronic microbial colonization
|
10 |
All |
18 Years and older (Adult, Older Adult) |
NCT01771159 |
1 |
TBC |
May 2017 |
December 2020 |
December 2022 |
January 18, 2013 |
May 11, 2016 |
|
|
|
| 46 |
NCT03308565 |
Recruiting |
Adipose Stem Cells for Traumatic Spinal Cord Injury |
- Spinal Cord Injuries
- Paralysis
|
- Biological: Autologous, Adipose derived Mesenchymal Stem Cells
|
Interventional
|
Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of acute adverse events
- Incidence of delayed adverse events
- Severity of adverse events
- (and 19 more...)
|
10 |
All |
18 Years and older (Adult, Older Adult) |
NCT03308565 |
17-004621 |
CELLTOP |
December 5, 2017 |
November 2022 |
November 2023 |
October 12, 2017 |
January 16, 2018 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
|
| 47 |
NCT02981576 |
Unknown † |
Safety and Effectiveness of BM-MSC vs AT-MSC in the Treatment of SCI Patients. |
|
- Biological: Autologous Mesenchymal Stem Cells
|
Interventional
|
Phase 1
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Comparing the number of side effects and the improvement on ASIA Impairment score between SCI patients receiving autologous AT-MSC vs BM-MSC.
- Investigating the number of side effects in SCI patients receiving autologous BM-MSC.
- Investigating the effectiveness of autologous BM-MSC in treating SCI patients.
- (and 2 more...)
|
14 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02981576 |
SCIUJCTC |
|
November 2016 |
May 2018 |
January 2019 |
December 5, 2016 |
January 31, 2017 |
|
- Cell Therapy Center, University of Jordan
Amman, Jordan
|
|
| 48 |
NCT03145142 |
Active, not recruiting |
PREMOD2 With Near Infrared Spectroscopy Sub-study |
- Hypoxia, Brain
- Premature Birth
|
- Procedure: Umbilical cord milking
- Procedure: Delayed Cord Clamping
|
Interventional
|
Not Applicable |
- Sharp HealthCare
- University of Ulm
- University College Cork
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- StO2 - 10M
- StO2 - 24H
- HR - 10M
- (and 2 more...)
|
121 |
All |
23 Weeks to 28 Weeks (Child) |
NCT03145142 |
PREMOD2 - NIRS Sub-study
1R01HD088646-01A1 |
PREMOD2 |
June 6, 2017 |
September 17, 2018 |
May 15, 2019 |
May 9, 2017 |
November 28, 2018 |
|
- Sharp Mary Birch Hospital for Women and Newborns
San Diego, California, United States - Governors of University of Alberta
Edmonton, Alberta, Canada - University of ULM
Ulm, Baden-Wurttemberg, Germany - Cork University Maternity Hospital
Cork, Ireland
|
|
| 49 |
NCT00597441 |
Terminated |
Phase I Study of Umbilical Cord Blood Transplantation Followed by Third Party Thymus Transplantation |
- Stem Cell Transplantation
|
- Biological: Thymic Transplantation for Recipients of UCB transplant
|
Interventional
|
Phase 1 |
- M. Louise Markert
- Duke University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Toxicity of thymus transplantation following unrelated umbilical cord blood transplantation. Emphasis will be placed on adverse events that are not typically associated with umbilical cord blood transplantation.
- To determine whether engraftment of a third party thymus allograft is feasible in patients who have undergone unrelated UCBT. Thymic engraftment will be determined by biopsy of the thymus allograft and immunohistochemical evidence of thymopoiesis.
- To assess thymic function by measuring the number of naive T cells and the number of T cell receptor rearrangement excision circles (TRECS), and by assessing the diversity of the T cell receptor beta chain.
|
6 |
All |
18 Years to 60 Years (Adult) |
NCT00597441 |
Pro00007995 |
|
November 2005 |
May 2010 |
May 2010 |
January 18, 2008 |
November 15, 2012 |
|
- Duke University Health System
Durham, North Carolina, United States
|
|
| 50 |
NCT00913471 |
Active, not recruiting |
Biomarkers for Pain in Spinal Cord Injury (SCI) Patients |
- Traumatic Spinal Cord Injury
- Neuropathic Pain
|
|
Observational
|
|
- The University of Texas Health Science Center, Houston
- The Institute for Rehabilitaion and Research Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- To identify candidate biomarkers for pain in the chronic SCI samples.
- To identify the temporal relationship of the development of pain and the manifestation of the biomarkers identified
|
120 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT00913471 |
HSC-MS-07-0452 |
SCI Pain |
June 2009 |
June 2021 |
December 2021 |
June 4, 2009 |
January 16, 2019 |
|
- Memorial Hermann Hospital
Houston, Texas, United States
|
|
| 51 |
NCT02719288 |
Completed |
Peroneal and Achilles Tendon Repair Indications With CLARIX® CORD 1K |
- Peroneal and Achilles Tendon Tears
|
- Biological: CLARIX® CORD 1K graft
|
Interventional
|
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Change from baseline in patient questionnaire describing function limitation (American Orthopaedic Foot and Ankle Society ankle hindfoot score).
|
64 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02719288 |
CR-2010 |
PATRICC |
February 15, 2016 |
December 18, 2018 |
December 18, 2018 |
March 25, 2016 |
January 7, 2019 |
|
- Banner Estrella Medical Center
Phoenix, Arizona, United States - Banner Del Webb Medical Center
Sun City West, Arizona, United States - OrthoCarolina Research Institute
Charlotte, North Carolina, United States - Orthopedic Foot and Ankle Center
Westerville, Ohio, United States
|
|
| 52 |
NCT00472784 |
Withdrawn |
Quantitative and Qualitative Changes in Neural Efferent Receptors |
- Spinal Cord Injury
- Bladder Dysfunction
|
|
Observational
|
|
- Baylor College of Medicine
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- The tissue is currently being analyzed - mRNA by microchip analysis and the data is still being worked on to look for correlations in genes up or down regulation versus the morphological EM findings previously reported.
|
0 |
Male |
18 Years to 64 Years (Adult) |
NCT00472784 |
H-6079 |
|
October 1998 |
December 2010 |
December 2010 |
May 14, 2007 |
May 11, 2016 |
|
- Baylor College of Medicine - Scott Department of Urology
Houston, Texas, United States - Michael E. DeBakey Veteran's Affairs Medcial Center
Houston, Texas, United States
|
|
| 53 |
NCT02827409 |
Completed |
Short-Delay Cord Clamping Compared to Extended- Delay Cord Clamping in Term Neonates That Require Resuscitation. |
|
- Procedure: Short Delay Cord Clamping
- Procedure: Extended Delay Cord Clamping
|
Interventional
|
Not Applicable |
- Anup Katheria, M.D.
- Sharp HealthCare
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Cerebral tissue oxygenation
- Heart rate
- Oxygen saturation
- (and 11 more...)
|
60 |
All |
37 Weeks to 42 Weeks (Child) |
NCT02827409 |
Term-NRIC |
Term-NRIC |
July 2016 |
September 2016 |
December 2016 |
July 11, 2016 |
June 8, 2017 |
|
- Sharp Mary Birch Hospital for Women and Newborns
San Diego, California, United States
|
|
| 54 |
NCT02166294 |
Terminated |
NEOX® CORD 1K vs Standard of Care in Non-healing Diabetic Foot Ulcers |
|
- Other: NEOX® CORD 1K
- Procedure: Standard of Care (Pressure Bandage)
|
Interventional
|
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Complete wound closure
- Number of participants with adverse events
- Number of applications
- (and 2 more...)
|
18 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02166294 |
NE-2001 |
CONDUCT I |
June 2014 |
June 2015 |
June 2015 |
June 18, 2014 |
June 27, 2017 |
|
- University of Arizona
Tucson, Arizona, United States - Center for Clinical Research, Inc.
Castro Valley, California, United States - Ankle and Foot Centers of Georgia
Newnan, Georgia, United States
|
|
| 55 |
NCT03798353 |
Not yet recruiting |
Pericardial Matrix With Mesenchymal Stem Cells for the Treatment of Patients With Infarcted Myocardial Tissue |
|
- Combination Product: PeriCord: Expanded and cryopreserved allogeneic umbilical cord Wharton´s jelly-derived adult mesenchymal stem cells colonized on human pericardial matrix.
- Procedure: Surgery by sternotomy
|
Interventional
|
Phase 1 |
- Fundació Institut Germans Trias i Pujol
- Germans Trias i Pujol Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Rate of death or rehospitalization due to any cause and / or adverse reactions related to the procedure / product under investigation.
- Death rate or rehospitalization due to cardiovascular causes
- Rate of relevant arrhythmias in Holter of 24 hours
- (and 6 more...)
|
10 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03798353 |
ICOR-2016-02 |
PERISCOPE |
March 2019 |
November 2020 |
November 2020 |
January 9, 2019 |
February 4, 2019 |
|
- Hospital Universitari Germans Trias i Pujol
Badalona, Barcelona, Spain
|
|
| 56 |
NCT03074487 |
Recruiting |
Evaluating Monitoring Techniques for Postoperative Spinal Cord Ischemia |
- Monitoring
- Postoperative
- Spinal Cord Ischemia
- (and 5 more...)
|
- Device: Near-infrared spectroscopy
- Device: Long loop reflex measurements
|
Observational
|
|
- Maastricht University Medical Center
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- changes in MEP signals perioperative
- Presence of LLR (F-waves) perioperative
- Oxygenation of the paraspinal muscle tissue measured by NIRS perioperative
- (and 2 more...)
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03074487 |
NL58137.068.16 |
SINATRA |
January 2017 |
December 2020 |
June 2021 |
March 8, 2017 |
September 5, 2018 |
|
- MaastrichtUMC
Maastricht, Limburg, Netherlands
|
|
| 57 |
NCT02707406 |
Active, not recruiting |
Non-healing Diabetic Foot Ulcers (DFU) Treated With SoC With or Without NEOX®CORD 1K |
|
- Other: NEOX®CORD 1K
- Other: standard of care
|
Interventional
|
Not Applicable |
- Tissue Tech Inc.
- Tissue Tech Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Incidence of adverse events collected throughout the trial compared between the two groups
- Proportion of subjects in NEOX® CORD 1KTM plus standard care against standard care with complete wound closure
- Time in days to wound closure
- (and 6 more...)
|
114 |
All |
18 Years and older (Adult, Older Adult) |
NCT02707406 |
NE-2011 |
|
February 2016 |
April 14, 2017 |
April 2018 |
March 14, 2016 |
April 24, 2018 |
|
- Carlsbad, California, United States
- Castro Valley, California, United States
- Fair Oaks, California, United States
- (and 19 more...)
|
|
| 58 |
NCT03644251 |
Recruiting |
FLO for Discogenic Pain |
|
- Other: amniotic and umbilical cord matrix
|
Interventional
|
Not Applicable |
- Tissue Tech Inc.
- Tissue Tech Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in patient back pain determined by visual analog scale
- Change in quality of life determined by SF-36
- Change in Oswestry Disability Index
|
15 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03644251 |
CLARIX-CS003 |
|
August 13, 2018 |
May 2019 |
August 2019 |
August 23, 2018 |
August 24, 2018 |
|
- Laser Spine Institute
Tampa, Florida, United States
|
|
| 59 |
NCT02518126 |
Unknown † |
Leukemia Inhibitory Factor Level in Intrauterine Growth Restriction Neonates |
- to Compare LIF Level in Cord Blood of Embryo's That Are IUGR to Those That Are AGA
|
- Other: blood sample and tissue sample
|
Observational
|
|
- Rambam Health Care Campus
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- LIF Protein Level in IUGR Neonates vs. AGA neonates
|
40 |
Female |
16 Years to 45 Years (Child, Adult) |
NCT02518126 |
0176-15-RMB CTIL |
|
August 2015 |
June 2017 |
June 2017 |
August 7, 2015 |
August 7, 2015 |
|
|
|
| 60 |
NCT02080039 |
Terminated |
Electrical Stimulation of Denervated Muscles After Spinal Cord Injury |
|
- Device: Electrical Stimulation
|
Interventional
|
Not Applicable |
- Swiss Paraplegic Centre Nottwil
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Magnetic Resonance Imaging to determine the thickness of the gluteal muscle and fat tissue of the buttock.
- Measuring of the seating pressure to determine the distribution of the middle and maximal seating pressure
- Questionnaire on subjective wellbeing
|
5 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02080039 |
2012‐13 |
|
September 2012 |
November 2014 |
November 2014 |
March 6, 2014 |
November 20, 2014 |
|
- Swiss Paraplegic Centre
Nottwil, LU, Switzerland
|
|
| 61 |
NCT03063827 |
Completed |
Effect of Botulinum Toxin A on Neurogenic Detrusor Overactivity in Chronic Spinal Cord Injured Patients |
|
- Drug: OnabotulinumtoxinA 200 UNT
- Diagnostic Test: Urothelial sensory protein levels
|
Observational
|
|
- Buddhist Tzu Chi General Hospital
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Bladder capacity
- IIQ-7
- UDI-6
- Sensory protein assessment
|
36 |
All |
18 Years and older (Adult, Older Adult) |
NCT03063827 |
BuddhistTCGH 098-53 |
|
January 2010 |
December 2012 |
December 2012 |
February 24, 2017 |
March 13, 2017 |
|
|
|
| 62 |
NCT02622464 |
Unknown † |
Innovative Treatment for Scarred Vocal Cords by Local Injection of Autologous Stromal Vascular Fraction |
|
- Other: micro injection of SVF in vocal cords
|
Interventional
|
Not Applicable |
- Assistance Publique Hopitaux De Marseille
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- feasibility of Stromal Vascular Fraction injection injected in vocal cords
- safety will be assessed by the absence of related events related to stromal vascular fraction injection injected in vocal cords
- efficiency of SVF injection for the treatment of scarred vocal cords with improved instrumental objective characteristics of the voice of the operated patients
|
8 |
All |
18 Years and older (Adult, Older Adult) |
NCT02622464 |
2015-01 |
|
December 2015 |
March 2017 |
May 2017 |
December 4, 2015 |
July 27, 2016 |
|
- Assisitance Publique Hopitaux de Marseille
Marseille, France
|
|
| 63 |
NCT03585075 |
Completed |
Characterization of the Autofluorescence of Healthy and Pathological Tissues of Vocal Cords |
|
|
Observational
|
|
- Centre Hospitalier Universitaire de Besancon
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- hyperspectral fluorescence of vocal folds
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03585075 |
P/2014/216 |
FLUOROCORD |
February 2014 |
February 2014 |
April 2016 |
July 12, 2018 |
July 12, 2018 |
|
- CHRU de Besancon
Besancon, France
|
|
| 64 |
NCT02058953 |
Recruiting |
CNS and Extracranial Tumor Tissues, CSF, and Blood From Patients With Melanoma Brain Metastases |
|
- Procedure: Craniotomy scheduled
- Procedure: Collection for non-craniotomy
|
Observational
|
|
- University of Pittsburgh
- GlaxoSmithKline
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Collection of blood, tumor tissue samples and adjacent uninvolved tissue and Cerebrospinal Fluid
|
50 |
All |
18 Years and older (Adult, Older Adult) |
NCT02058953 |
UPCI 13-052 (IMWG-01) |
13-052 |
August 2014 |
August 31, 2019 |
August 31, 2019 |
February 11, 2014 |
October 4, 2018 |
|
- University of Pittsburgh Medical Center- Hillman Cancer Center
Pittsburgh, Pennsylvania, United States - The University of Texas- MD Anderson Cancer Center
Houston, Texas, United States - Melanoma Institute Australia- Westmead Institute for Cancer Research
Sydney, Australia
|
|
| 65 |
NCT01880112 |
Withdrawn |
Serum and Tissue Cefazolin Concentrations in Normal Weight Patients Undergoing Cesarean Delivery. |
- Infection
- Cesarean Delivery
- Antibiotic Prophylaxis
|
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
|
0 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01880112 |
H-23256 |
|
June 2011 |
June 2013 |
June 2013 |
June 18, 2013 |
June 18, 2013 |
|
- West Virginia University Hospital
Morgantown, West Virginia, United States
|
|
| 66 |
NCT02482194 |
Completed |
Autologous Mesenchymal Stem Cells Transplantation for Spinal Cord Injury- A Phase I Clinical Study |
|
- Biological: mesenchymal stem cells
|
Interventional
|
Phase 1 |
- Armed Forces Bone Marrow Transplant Center, Rawalpindi, Pakistan
- Armed Forces Institute of Regenerative Medicine
|
Other / U.S. Fed |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of adverse events
- Sensory and motor strength
- Functional Independence
- Muscle strength assessment
|
9 |
All |
18 Years to 50 Years (Adult) |
NCT02482194 |
AFBMTC-SCI-2013 |
|
June 2013 |
January 2016 |
March 2016 |
June 26, 2015 |
June 29, 2016 |
|
- Armed Forces Bone Marrow Transplant Centre
Rawalpindi, Pakistan
|
|
| 67 |
NCT02785367 |
Not yet recruiting |
Changes of Gas Values in Cord Blood Versus Time and Temperature |
|
- Procedure: Cord blood samples
|
Interventional
|
Phase 4 |
- Tel-Aviv Sourasky Medical Center
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
1000 |
Female |
18 Years to 50 Years (Adult) |
NCT02785367 |
0042-46-tlv |
|
June 2016 |
June 2019 |
June 2019 |
May 27, 2016 |
May 27, 2016 |
|
|
|
| 68 |
NCT03296436 |
Not yet recruiting |
A Pilot Study to Assess the Efficacy of NEOX® CORD 1K® in the Treatment of Complex Diabetic Wounds |
- Vascular Ulcer (Arterial or Venous Including Diabetic Ulcers Not Located on the Foot)
- Diabetic Foot Ulcer
- Diabetic Foot
- (and 2 more...)
|
- Biological: NEOX® CORD 1K®
|
Interventional
|
Early Phase 1 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- complete ulcer closure
- NEOX CORD 1K applications
- ulcer surface area
- (and 3 more...)
|
10 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03296436 |
IRB00145403 |
|
January 2019 |
October 2019 |
October 2019 |
September 28, 2017 |
October 9, 2018 |
|
|
|
| 69 |
NCT02866708 |
Completed |
The Effects of Intermittent Negative Pressure on Wound Healing and Peripheral Circulation in Spinal Cord Injured Subjects |
- Wound Healing, Leg and Foot Ulcers, Macrocirculation, Microcirculation
|
- Device: Intermittent negative pressure device
|
Interventional
|
Not Applicable |
- Oslo University Hospital
- Otivio AS
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Percentage change in wound healing after 8 weeks of control and after 8 weeks of INP therapy
- Photographic wound assessment tool, PWAT 0-24 score
- Change in Quality of life (SF-36 ) after 8 weeks of control and after 8 weeks of INP therapy
- (and 4 more...)
|
9 |
All |
18 Years to 96 Years (Adult, Older Adult) |
NCT02866708 |
2015/1318 REK sørøst D |
|
July 1, 2016 |
April 2017 |
April 20, 2017 |
August 15, 2016 |
September 7, 2017 |
|
- Sunnaas Rehabilitation Hospital
Nesodden, Akershus, Norway
|
|
| 70 |
NCT00594178 |
Completed
Has Results |
Palliative Strategies in Spinal Cord Injury (SCI) |
|
- Device: Motorized bicycle exercise training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Muscle Mass Via Dual-Energy X-ray Absortiometry (DEXA)Scan Data
- Bone Density Via Dual-Energy X-ray Absortiometry (DEXA) Scan
|
17 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT00594178 |
24179
PRN # 12903 NIH |
|
October 2003 |
July 2008 |
September 2010 |
January 15, 2008 |
January 13, 2011 |
January 13, 2011 |
- Center for Translational Neuroscience #847
Little Rock, Arkansas, United States
|
|
| 71 |
NCT03562065 |
Not yet recruiting |
Treatment of Refractory Systemic Lupus Erythematosus by Allogeneic Mesenchymal Stem Cells Derived From the Umbilical Cord |
- Lupus Erythematosus
- Stem Cell Transplant
|
- Biological: mesenchymal stem cells
|
Interventional
|
Phase 1
Phase 2 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Toxicity of allogeneic MSC injection according to CTCAE
- Toxicity of allogeneic MSC injection according to CTCAE Month 1
- Toxicity of allogeneic MSC injection according to CTCAE Month 3
- (and 34 more...)
|
10 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03562065 |
P150302 |
MSC-SLE |
July 1, 2018 |
June 1, 2021 |
June 1, 2021 |
June 19, 2018 |
June 19, 2018 |
|
- Saint-Louis Hospital
Paris, France
|
|
| 72 |
NCT01433159 |
Terminated
Has Results |
Comparison of HP011-101 to Standard Care for Stage I-II Pressure Ulcers in Subjects With Spinal Cord Injury |
- Pressure Ulcers
- Spinal Cord Injury
|
- Drug: HP011-101 (Xenaderm Ointment)
- Drug: Standard Care
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change From Baseline in Composite PUSH (Pressure Ulcer Scale for Healing) Score
|
19 |
All |
12 Years and older (Child, Adult, Older Adult) |
NCT01433159 |
011-101-09-043 |
|
September 2011 |
January 2013 |
January 2013 |
September 13, 2011 |
February 10, 2014 |
February 10, 2014 |
- VA Medical Center, Long Beach
Long Beach, California, United States - Santa Clara Valley Medical Center
San Jose, California, United States - James A. Haley Veterans Hospital, Tampa
Tampa, Florida, United States - (and 2 more...)
|
|
| 73 |
NCT03800810 |
Recruiting |
Implantation of Allogenic Mesenchymal Stem Cell From Umbilical Cord Blood for Osteoarthritis Management |
|
- Drug: Hyaluronic Acid
- Biological: Umbilical Cord Mesenchymal Stem Cell
- Biological: Recombinant Human Somatropin
|
Interventional
|
Early Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Cartilage T2 map score
- IKDC score
- WOMAC score
- VAS score
|
9 |
All |
30 Years to 80 Years (Adult, Older Adult) |
NCT03800810 |
ISMMSCOA |
|
May 2015 |
May 2019 |
May 2019 |
January 11, 2019 |
January 23, 2019 |
|
- Universitas Indonesia
Jakarta Pusat, Jakarta, Indonesia
|
|
| 74 |
NCT00681642 |
Completed |
Corneal Epithelial Wound Healing Difference Between Human Autoserum and Cord Blood Serum |
- Corneal Epithelial Wound Healing
|
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Cell proliferation
- Cell migration
|
7 |
All |
Child, Adult, Older Adult |
NCT00681642 |
200702037R |
|
March 2007 |
March 2008 |
March 2008 |
May 21, 2008 |
January 10, 2011 |
|
- National Taiwan University Hospital, department of Ophthalmology
Taipei, Taiwan
|
|
| 75 |
NCT00073853 |
Suspended |
Autologous Incubated Macrophages for Patients With Complete Spinal Cord Injuries |
|
- Procedure: Autologous Incubated Macrophages (cell therapy)
|
Interventional
|
Phase 2 |
- Proneuron Biotechnologies
- The Marcus Foundation
- B.I.R.D. (Israel-U.S. Binational Industrial Research and Development)
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Improvement of ASIA grade
- Sensory scores
- Motor scores
- Bladder and bowel function
|
61 |
All |
16 Years to 65 Years (Child, Adult, Older Adult) |
NCT00073853 |
22-P-01 |
|
September 2003 |
|
|
December 11, 2003 |
August 28, 2009 |
|
- Craig Hospital
Englewood, Colorado, United States - Shepherd Center
Atlanta, Georgia, United States - UMDNJ
Newark, New Jersey, United States - (and 4 more...)
|
|
| 76 |
NCT01755026 |
Completed
Has Results |
Serum and Tissue Cefazolin Concentrations in Patients Undergoing Cesarean Delivery |
- Cesarean Delivery
- Wound Infection
- Obesity
|
|
Interventional
|
Phase 4 |
- Michael Stitely
- West Virginia University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
|
23 |
Female |
18 Years and older (Adult, Older Adult) |
NCT01755026 |
H-22512 |
|
November 2010 |
July 2011 |
November 2012 |
December 21, 2012 |
August 21, 2013 |
August 21, 2013 |
- West Virginia University Hospital
Morgantown, West Virginia, United States
|
|
| 77 |
NCT00604201 |
Recruiting |
Stem Cell Transplant Using Peripheral and Cord Blood Stem Cells to Treat Severe Aplastic Anemia and Myelopdysplastic Syndrome |
- Myelodysplastic Syndrome (MDS)
- Severe Aplastic Anemia (SAA)
|
- Other: Umbilical Cord Blood
- Other: Haploidentical Stem Cells
- Device: Miltenvi CliniMACs CD34 Reagent System
|
Interventional
|
Phase 2 |
- National Heart, Lung, and Blood Institute (NHLBI)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Day 42 cord engraftment
- 200 day treatment related mortality (TRM) and standard transplant outcome variables (non-hematological toxicities, incidence and severity of acute and chronic GVHD, and relapse of disease)
|
100 |
All |
4 Years to 75 Years (Child, Adult, Older Adult) |
NCT00604201 |
080046
08-H-0046 |
|
January 7, 2008 |
December 31, 2019 |
December 31, 2019 |
January 30, 2008 |
January 1, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 78 |
NCT02031835 |
Recruiting |
Body Weight Supported Treadmill Training as Physical Therapy Treatment to Spinal Cord Injury Patients |
- Spinal Cord Injury/Damage
|
- Procedure: BWSTT (3 days a week for maximum of 20 minutes session)
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- WISCI II
- ASIA standard neurological classification for spinal cord injury patients working sheet
- Modified Ashworth scale
- (and 5 more...)
|
50 |
All |
8 Years to 88 Years (Child, Adult, Older Adult) |
NCT02031835 |
UIoannina612014 |
|
March 2012 |
March 2019 |
March 2019 |
January 9, 2014 |
October 11, 2018 |
|
- University Hospital of Ioannina
Ioannina, Greece
|
|
| 79 |
NCT02412046 |
Recruiting |
Quantification of the Pressure Threshold Related to Tissue Injury in Bedriden Paraplegics |
- Pressure Ulcer
- Bedsore
- Spinal Cord Injury
- Paraplegia
|
|
Interventional
|
Not Applicable |
- University Hospital, Montpellier
- Hill-Rom
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- The interface pressure will be continuously assessed using a mapping device (XSensor) during 3 hours.
- The microvascularization changes underneath the compressed skin and the inflammatory response of the muscle cells.
|
48 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02412046 |
95022 |
|
October 1, 2015 |
October 2019 |
October 2019 |
April 8, 2015 |
November 29, 2018 |
|
- CHU Montpellier
Montpellier, France
|
|
| 80 |
NCT01909154 |
Completed |
Safety Study of Local Administration of Autologous Bone Marrow Stromal Cells in Chronic Paraplegia |
|
- Biological: Mesenchymal stromal cell therapy
|
Interventional
|
Phase 1 |
- Puerta de Hierro University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
12 |
All |
18 Years to 60 Years (Adult) |
NCT01909154 |
CME-LEM1
2010-023285-46 |
CME-LEM1 |
March 2013 |
April 2014 |
March 2015 |
July 26, 2013 |
June 18, 2015 |
|
- Hospital Puerta de Hierro
Majadahonda, Madrid, Spain
|
|
| 81 |
NCT02053883 |
Withdrawn |
Cethrin in Acute Cervical Spinal Cord Injury |
|
- Drug: Cethrin (BA-210)
- Drug: Placebo
|
Interventional
|
Phase 2
Phase 3 |
- BioAxone BioSciences, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- American Spinal Injury Association (ASIA) Upper Extremity Motor Score Recovery
- ASIA Total Motor Score Recovery
- ASIA Impairment Scale (AIS) Grade Recovery
- (and 5 more...)
|
0 |
All |
18 Years to 62 Years (Adult) |
NCT02053883 |
BA-210-201 |
|
July 2015 |
May 2016 |
|
February 4, 2014 |
November 26, 2014 |
|
|
|
| 82 |
NCT01547091 |
Unknown † |
Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis |
|
- Biological: Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs)
- Drug: Rheumatoid Arthritis With Disease-Modifying Drugs (DMARDs)
- Biological: UC-MSC+DMARDS
|
Interventional
|
Phase 1
Phase 2 |
- Alliancells Bioscience Corporation Limited
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Safety of MSC treatment.
- RA Serology
- Disease Activity Score (DAS 28) Index Mean Change From Baseline
- Patient's assessment of pain.
|
200 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT01547091 |
Alliancells-1 |
RA |
April 2013 |
October 2014 |
December 2014 |
March 7, 2012 |
June 27, 2013 |
|
- The 323 Hospital of Chinese People's Liberation Army
Xi'an, Shaanxi, China
|
|
| 83 |
NCT01162915 |
Suspended |
Transfer of Bone Marrow Derived Stem Cells for the Treatment of Spinal Cord Injury |
|
- Biological: Autologous bone marrow-derived mesenchymal stem cells.
|
Interventional
|
Phase 1 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
10 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01162915 |
2009-SCI-I |
|
July 2010 |
May 2014 |
May 2014 |
July 15, 2010 |
May 9, 2014 |
|
- TCA Cellular Therapy, LLC
Covington, Louisiana, United States
|
|
| 84 |
NCT01597778 |
Active, not recruiting |
Double Cord Versus Haploidentical (BMT CTN 1101) |
- Acute Lymphocytic Leukemia
- Acute Myelogenous Leukemia
- Burkitt's Lymphoma
- (and 4 more...)
|
- Biological: Haploidentical Bone Marrow Transplant
- Biological: Double Umbilical Cord Blood Transplant
|
Interventional
|
Phase 3 |
- Medical College of Wisconsin
- National Heart, Lung, and Blood Institute (NHLBI)
- National Cancer Institute (NCI)
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Progression Free Survival (PFS)
- Neutrophil Recovery
- Primary Graft Failure
- (and 8 more...)
|
368 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT01597778 |
BMTCTN1101
2U10HL069294-11
5U24CA076518 |
|
June 2012 |
June 2020 |
June 2020 |
May 14, 2012 |
October 19, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Arizona Cancer Center
Phoenix, Arizona, United States - Mayo Clinic Phoenix
Phoenix, Arizona, United States - (and 40 more...)
|
|
| 85 |
NCT02659956 |
Recruiting |
Pathological Basis of MRI Signal Changes in Multiple Sclerosis |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Correlation among in vivo imaging, postmortem imaging, and pathological characteristics of individual areas of tissue damage ("lesions") in the brain, spinal cord, and retinas.
- Correlation among in vivo imaging, postmortem imaging, and pathological characteristics of nonlesional structures in the brain, spinal cord, and retinas.
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT02659956 |
160055
16-N-0055 |
|
January 20, 2016 |
February 26, 2030 |
February 26, 2041 |
January 21, 2016 |
December 6, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 86 |
NCT02182180 |
Recruiting |
SC2i Tissue and Data Repository Protocol |
|
|
Observational
|
|
- Henry M. Jackson Foundation for the Advancement of Military Medicine
- Uniformed Services University of the Health Sciences
- United States Department of Defense
- (and 4 more...)
|
Other / U.S. Fed |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Collecting, processing and archiving human tissue
|
5000 |
All |
18 Years and older (Adult, Older Adult) |
NCT02182180 |
SC2I SUR902506
HT94041310032 |
SC2i |
November 2014 |
September 2019 |
October 2019 |
July 8, 2014 |
August 3, 2018 |
|
- Grady Health Systems
Atlanta, Georgia, United States - Emory University
Atlanta, Georgia, United States - Duke University Health Systems
Durham, North Carolina, United States
|
|
| 87 |
NCT02383537 |
Not yet recruiting |
Biological Changes in the Adipose Tissue Among Pregnant Women With Diabetes |
|
|
Observational
|
|
- Hadassah Medical Organization
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
|
150 |
Female |
18 Years to 45 Years (Adult) |
NCT02383537 |
0633-14-HMO |
|
April 2017 |
February 2019 |
February 2020 |
March 9, 2015 |
September 2, 2016 |
|
|
|
| 88 |
NCT03606239 |
Recruiting |
NSCLC Isotoxic Hypofractionated Chemoradiotherapy |
- Carcinoma, Non-Small-Cell Lung
|
- Radiation: isotoxic hypofractionated group
|
Interventional
|
Not Applicable |
- The Second Hospital of Hebei Medical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- radiation induced esophagitis and radiation induced pneumonitis
- time to disease progression (TTP)
- progression-free survival(PFS)
- (and 2 more...)
|
30 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT03606239 |
NSCLS isotoxic HypoRCT |
IHRC |
February 1, 2019 |
February 1, 2021 |
February 1, 2026 |
July 30, 2018 |
February 12, 2019 |
|
- The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
|
|
| 89 |
NCT00678158 |
Completed |
Study Using High-Dose Single Fraction Image-Guided Radiotherapy for Metastatic Lesions to Soft Tissue Masses, Lymph Node, or Bone |
|
- Radiation: intensity modulated radiation therapy
|
Interventional
|
Phase 1 |
- Memorial Sloan Kettering Cancer Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To assess the feasibility of single dose image-guided intensity modulated radiotherapy (IGIMRT)for metastatic disease to soft tissue, lymph nodes or bones.
- To establish the maximal safe single fraction dose for osseous and soft tissue metastatic lesions using IG-IMRT in a Phase I dose escalation study.
- To obtain information on the effect of high-dose external beam irradiation on the biodistribution and pharmacokinetics of FLT.
- To obtain preliminary information on the changes in tumor perfusion resulting from high-dose, single fraction IGRT for patients treated with approach to focal metastases using dynamic contrast-enhanced (DCE)-MRI.
|
68 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT00678158 |
06-101 |
|
August 2006 |
November 2015 |
November 2015 |
May 15, 2008 |
November 17, 2015 |
|
- Memorial Sloan Kettering Cancer Center
New York, New York, United States
|
|
| 90 |
NCT01244594 |
Completed |
The Effects of Two Functional Electrical Stimulation Cycling Paradigms |
|
- Other: Cycling with functional electrical stimulation
|
Interventional
|
Phase 2
Phase 3 |
- Thomas Jefferson University
- The Craig H. Neilsen Foundation
- Magee Rehabilitation Hospital
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Bone density and bone microarchitecture
- Muscle volume
- Muscle strength
- (and 2 more...)
|
17 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01244594 |
164600 |
|
July 2010 |
October 2013 |
October 2013 |
November 19, 2010 |
January 8, 2014 |
|
- Magee Rehabilitation Hospital
Philadelphia, Pennsylvania, United States - Thomas Jefferson University Hospital
Philadelphia, Pennsylvania, United States - Thomas Jefferson University
Philadelphia, Pennsylvania, United States
|
|
| 91 |
NCT03606291 |
Recruiting |
NSCLC Isotoxic Hypofractionated Radiotherapy |
- Carcinoma, Non-Small-Cell Lung
|
- Radiation: isotoxic hypofractionation
|
Interventional
|
Not Applicable |
- The Second Hospital of Hebei Medical University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- radiation induced esophagitis and radiation induced pneumonitis
- TTP
- PFS
- (and 2 more...)
|
30 |
All |
18 Years and older (Adult, Older Adult) |
NCT03606291 |
NSCLC isotoxic HypoRT |
IHR |
February 1, 2019 |
February 1, 2021 |
February 1, 2026 |
July 30, 2018 |
February 12, 2019 |
|
- The Second Hospital of Hebei Medical University
Shijiazhuang, Hebei, China
|
|
| 92 |
NCT01576211 |
Completed |
Studying Genes Using Cord Blood and Placenta Samples From Relatively Healthy Newborns and Samples From Younger Patients With Wilms Tumor |
|
- Genetic: DNA methylation analysis
- Genetic: RNA analysis
- Genetic: allele-specific oligonucleotide real-time quantitative polymerase chain reaction
- (and 4 more...)
|
Observational
|
|
- Children's Oncology Group
- National Cancer Institute (NCI)
|
Other / NIH |
- Observational Model: Case Control
- Time Perspective: Retrospective
|
- Frequency of loss of imprinting at birth
- Association between methylation levels and gene expression
|
40 |
All |
up to 21 Years (Child, Adult) |
NCT01576211 |
AREN12B6
COG-AREN12B6
CDR0000730596
NCI-2012-00726 |
|
April 2012 |
May 2016 |
|
April 12, 2012 |
May 18, 2016 |
|
|
|
| 93 |
NCT03798093 |
Recruiting |
MINVI Echocardiography Sub-Study |
|
- Procedure: Umbilical Cord Milking
- Procedure: Early Cord Clamping
|
Interventional
|
Not Applicable |
- Sharp HealthCare
- Sharp Mary Birch Hospital for Women & Newborns
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Cardiac Output
- Right Ventricular Output
- SVC Flow
- (and 2 more...)
|
200 |
All |
35 Weeks to 42 Weeks (Child) |
NCT03798093 |
MINVI Echo Study |
|
January 7, 2019 |
June 2020 |
June 2021 |
January 9, 2019 |
January 17, 2019 |
|
- Sharp Mary Birch Hospital for Women and Newborns
San Diego, California, United States
|
|
| 94 |
NCT03053791 |
Recruiting |
Deep Brain Stimulation in Patients With Incomplete Spinal Cord Injury for Improvement of Gait |
|
- Procedure: Deep brain stimulation in mesencephalic locomotor region
- Device: Implantation of a Deep brain stimulation system
|
Interventional
|
Not Applicable |
- University of Zurich
- Balgrist University Hospital
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in 6 Minute Walk Test at baseline and 6 months post intervention
- Change in Timed Up and Go test (TUG) towards baseline
- Change in 6 Minute Walk Test towards baseline
- (and 6 more...)
|
5 |
All |
18 Years and older (Adult, Older Adult) |
NCT03053791 |
SNCTP000000598 |
DBS-SCI |
February 1, 2017 |
April 2020 |
December 2020 |
February 15, 2017 |
October 19, 2018 |
|
- Balgrist University Hospital
Zurich, Switzerland
|
|
| 95 |
NCT00781066 |
Completed |
Controlled Cord Traction During Third Stage of Labor |
|
- Procedure: Controlled cord traction
- Procedure: No controlled cord traction
|
Interventional
|
Phase 3 |
- Universidad de la Republica
- Unidad de Investigación Clínica y Epidemiológica Montevideo
- Institute for Clinical Effectiveness and Health Policy
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Postpartum blood loss
- Manual removal of placenta
- Uterine inversion
- (and 3 more...)
|
200 |
Female |
18 Years and older (Adult, Older Adult) |
NCT00781066 |
CCT 06-00051
D43TW005492 (NIH grant number)
D43TW005492 |
CCT |
January 2007 |
September 2007 |
September 2007 |
October 28, 2008 |
October 28, 2008 |
|
- Clinica's Hospital Manuel Quintela of the University of the Republic of Uruguay
Montevideo, Uruguay - Pereira Rossell Hospital
Montevideo, Uruguay
|
|
| 96 |
NCT03529136 |
Not yet recruiting |
Clinical Trial of Umbilical Cord Mesenchymal Stem Cell Transfusion in Decompensated Liver Cirrhosis |
- Decompensated Liver Cirrhosis
|
|
Interventional
|
Phase 2 |
- Shandong Qilu Stem Cells Engineering Co., Ltd.
- Shanghai Public Health Clinical Center
- First Affiliated Hospital of Fujian Medical University
- (and 3 more...)
|
Industry / Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
252 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03529136 |
CTR1800015304 |
|
June 1, 2018 |
December 31, 2019 |
April 30, 2020 |
May 18, 2018 |
May 18, 2018 |
|
|
|
| 97 |
NCT01036529 |
Terminated
Has Results |
Spinal Cord Stimulation With Precision® System Versus Reoperation for Failed Back Surgery Syndrome |
- Failed Back Surgery Syndrome
- Pain
- Back Pain
|
- Device: Precision Spinal Cord Stimulator
- Procedure: Back Surgery
|
Interventional
|
Phase 4 |
- Boston Scientific Corporation
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of Subjects Showing ≥50% Self-reported Leg Pain Relief From Baseline Without Request for Crossover to the Other Treatment
|
28 |
All |
18 Years and older (Adult, Older Adult) |
NCT01036529 |
A2005 |
Evidence |
February 2010 |
May 2013 |
May 2013 |
December 21, 2009 |
October 28, 2013 |
October 28, 2013 |
- Scripps Clinic
La Jolla, California, United States - University of California San Diego
La Jolla, California, United States - Orthopedic Research Foundation
Savannah, Georgia, United States - (and 15 more...)
|
|
| 98 |
NCT01865942 |
Completed |
Surgical Spinal Decompression of Metastatic Spinal Cord Compression, Minimal Access Versus Open Surgery |
|
- Procedure: open surgery
- Procedure: Minimal access surgery
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Bleeding
- Health related quality of life measured with questionnaire EQ-5D and QLQ-C30
|
50 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT01865942 |
H-2-2011-050 |
|
August 28, 2014 |
January 2, 2017 |
March 30, 2017 |
May 31, 2013 |
April 4, 2017 |
|
- Rigshospitalet
Copenhagen, Denmark
|
|
| 99 |
NCT01899664 |
Active, not recruiting |
Upper Extremity Surgery in Spinal Cord Injury |
- Quadriplegia
- Spinal Cord Diseases
- Spinal Cord Injuries
|
- Procedure: Nerve Transfer Surgery
|
Interventional
|
Not Applicable |
- Washington University School of Medicine
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Upper extremity function.
- Health related quality of life.
|
17 |
All |
18 Years to 60 Years (Adult) |
NCT01899664 |
201205104 |
|
June 2012 |
August 2020 |
August 2020 |
July 15, 2013 |
August 27, 2018 |
|
- Washington University Division of Plastic Surgery
Saint Louis, Missouri, United States
|
|
| 100 |
NCT03368599 |
Recruiting |
Endobronchial Intubation of Double-lumen Tube: Conventional Method vs Fiberoptic Bronchoscope Guide Method |
- Intubation, Intratracheal
- Postoperative Complications
- Sore Throat
- (and 3 more...)
|
- Procedure: Bronchoscope guided advancement
- Procedure: Conventional advancement
|
Interventional
|
Not Applicable |
- Seoul National University Bundang Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Post-operative sore throat (1 h)
- Post-operative sore throat (24 h)
- Post-operative hoarseness (1 h)
- (and 12 more...)
|
136 |
All |
20 Years to 75 Years (Adult, Older Adult) |
NCT03368599 |
B-1711-432-005 |
|
January 15, 2018 |
May 25, 2019 |
July 31, 2019 |
December 11, 2017 |
February 7, 2019 |
|
- Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of
|
|
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