| 1 |
NCT02764203 |
Completed |
ChOcolate COnsumption And Blood Pressure (COCOA-BP): A Wearable Devices Pilot Trial |
- Health Behavior
- Blood Pressure
|
- Other: Dark Chocolate
- Device: Wearable devices
|
Interventional |
Not Applicable |
- Boston Scientific Corporation
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in resting systolic blood pressure after daily dark chocolate
- Correlation of physical activity (steps) to resting blood pressure and heart rate
- Comparison of blood pressure derived from wearable digital health devices to data derived from standard methods
- Comparison of heart rate derived from wearable digital health devices to data derived from standard methods
|
67 |
All |
18 Years and older (Adult, Senior) |
NCT02764203 |
S2363 |
COCOA-BP |
September 16, 2016 |
September 12, 2017 |
September 12, 2017 |
May 6, 2016 |
October 4, 2017 |
|
|
| 2 |
NCT03203824 |
Recruiting |
The Effects of Dark Chocolate (70% Cacao) on EEG Brain Waves in Vigorously Active Individuals |
|
- Dietary Supplement: dark chocolate
- Other: non dark chocolate
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- EEG Wave Band Activity without dark chocolate ingestion
- EEG wave band activity with dark chocolate ingestion
|
10 |
All |
21 Years to 45 Years (Adult) |
NCT03203824 |
5170184 |
|
September 5, 2017 |
May 1, 2018 |
May 1, 2018 |
June 29, 2017 |
September 28, 2017 |
|
- Loma Linda U
Loma Linda, California, United States
|
| 3 |
NCT02275884 |
Unknown † |
Pharmacologically Active Constituents of Chocolate and Their Symptomatic Effects in Patients With Idiopathic Parkinson's Disease |
|
- Dietary Supplement: Dark chocolate (85% cocoa)
- Dietary Supplement: White chocolate (0% cocoa)
|
Interventional |
Not Applicable |
- Technische Universität Dresden
- University of Wuerzburg
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Change in plasma concentrations of pharmacologically active constituents of chocolate after one week consumption of dark chocolate in comparison to baseline and to one week consumption of white chocolate
- Change in the severity of motor and non-motor symptoms of PD after one week consumption of dark chocolate in comparison to baseline and to one week consumption of white chocolate
- Change in cognitive measures (MoCA, SCOPA-COG) after one week consumption of dark chocolate in comparison to baseline and to one week consumption of white chocolate
- (and 2 more...)
|
30 |
All |
40 Years and older (Adult, Senior) |
NCT02275884 |
EK366112012 |
Choc-PD |
June 2013 |
April 2015 |
June 2015 |
October 27, 2014 |
October 27, 2014 |
|
- Department of Neurology, Dresden University of Technology
Dresden, Saxony, Germany
|
| 4 |
NCT03364413 |
Completed |
Brain's Response to Chocolate |
|
|
Observational |
|
- USDA Grand Forks Human Nutrition Research Center
- Drexel University
|
U.S. Fed / Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Retinal dopamine response
|
20 |
All |
18 Years to 50 Years (Adult) |
NCT03364413 |
GFHNRC217 |
|
January 17, 2018 |
March 2, 2018 |
March 2, 2018 |
December 6, 2017 |
April 5, 2018 |
|
- USDA Grand Forks Human Nutrition Research Center
Grand Forks, North Dakota, United States
|
| 5 |
NCT00790465 |
Unknown † |
Efficacy of Dark Chocolate in Achalasia Patients |
|
- Dietary Supplement: dark chocolate
- Dietary Supplement: placebo chocolate with crossover to dark chocolate
|
Interventional |
Phase 1
Phase 2 |
- Tel-Aviv Sourasky Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Lower Esophageal Sphincter relaxation before and after dark chocolate consumption.
- achalasia symptoms before and during dark-chocolate consumption
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT00790465 |
TASMC-08-GR-370-CTIL
achalasia1 |
|
November 2008 |
November 2009 |
November 2010 |
November 13, 2008 |
November 13, 2008 |
|
|
| 6 |
NCT02924857 |
Recruiting |
The Chocolate Touch Study |
- Intermittent Claudication
- Ischemia
|
- Device: Chocolate Touch
- Device: Lutonix Drug Coated Balloon
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- True Drug Coated Balloon Success
- Freedom from Major Adverse Events
- By Angiographic Core Lab Review (Acute)
- (and 2 more...)
|
585 |
All |
18 Years and older (Adult, Senior) |
NCT02924857 |
CLP788 |
|
July 26, 2017 |
December 2018 |
December 2022 |
October 5, 2016 |
November 17, 2017 |
|
- Cardiac and Vascular Institute
Gainesville, Florida, United States - Alexian Brothers
Elk Grove Village, Illinois, United States - St. Joseph's Hospital
Lexington, Kentucky, United States - (and 15 more...)
|
| 7 |
NCT03326934 |
Completed |
Impact of Dark Chocolate on Visual Performance |
|
- Dietary Supplement: Dark chocolate
- Dietary Supplement: Milk Chocolate
|
Interventional |
Not Applicable |
- University of the Incarnate Word
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Visual acuity, contrast sensitivity and color vision.
- Effects of distraction on visual performance during simulated hands-free phone calls.
- Visual-electrodiagnostic testing.
- Simulated marksmanship.
|
30 |
All |
18 Years to 65 Years (Adult) |
NCT03326934 |
17-06-002 |
|
June 25, 2017 |
August 15, 2017 |
August 15, 2017 |
October 31, 2017 |
October 31, 2017 |
|
- University of the Incarnate Word Rosenberg School of Optometry
San Antonio, Texas, United States
|
| 8 |
NCT01431443 |
Completed |
Consumption of Chocolate in Pregnant Women. |
|
- Other: Flavanol-rich chocolate
- Other: Placebo Chocolate
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Changes in endothelial function
- Doppler of uterine arteries
- Blood pressure
- (and 2 more...)
|
160 |
Female |
18 Years to 40 Years (Adult) |
NCT01431443 |
IC096501 |
CHOCENTA |
May 2011 |
September 2014 |
September 2014 |
September 9, 2011 |
April 9, 2015 |
|
- Laval University, Department of Medicine, Institut des nutraceutiques et des aliments fonctionnels.
Québec, Quebec, Canada
|
| 9 |
NCT01659060 |
Completed |
Chocolate Consumption in Healthy Pregnant Women Trial |
- Hypertension Pregnancy-induced
|
- Other: Flavanol-rich dark chocolate
- Other: Placebo Chocolate
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Changes in endothelial function and blood pressure
- Changes from baseline in plasma flavanol and methylxanthines(caffeine, theobromine and theophylline) concentrations at 12 weeks
- Weight change from baseline at 12 weeks
- Number of participants with digestive and other signs and symptoms (nausea, abdominal pain, constipation, and headache)
|
44 |
Female |
18 Years to 35 Years (Adult) |
NCT01659060 |
119.05.03 |
|
July 2008 |
April 2009 |
April 2009 |
August 7, 2012 |
August 7, 2012 |
|
- Laval University, Department of Medicine, Institut des nutraceutiques et des aliments fonctionnels
Québec, Quebec, Canada
|
| 10 |
NCT03288623 |
Recruiting |
The Effects of Dark Chocolate Implementation in Elite Athletes |
- Oxidative Stress
- Athletes Heart
- Physical Activity
|
- Dietary Supplement: Dark Chocolate (85% cocoa)
- Dietary Supplement: White/Milk chocolate (<35% cocoa)
|
Interventional |
Not Applicable |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Soluble NOX2-derived peptides (sNOX2-dp)
- soluble P-selectin (sPs)
- soluble CD40 Ligands (sCD40L)
- (and 4 more...)
|
24 |
Male |
18 Years to 35 Years (Adult) |
NCT03288623 |
CE 4662 |
|
September 11, 2017 |
December 2017 |
December 2018 |
September 20, 2017 |
September 29, 2017 |
|
- Sapienza University of Rome, Policlinico Umberto I
Rome, Italy
|
| 11 |
NCT02130141 |
Completed |
The Effects of Dark Chocolate on Blood Pressure in Individuals With Mildly Elevated Blood Pressure |
|
- Dietary Supplement: Dark chocolate
- Other: Dietary counselling
|
Interventional |
Not Applicable |
- Helsinki University
- Fazer Group
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
|
- Changes in systolic and diastolic blood pressure
- Ambulatory blood pressure
- Blood lipids, inflammation markers, plasma levels of cocoa polyphenols
|
30 |
All |
25 Years to 65 Years (Adult) |
NCT02130141 |
HY-RAV-FAZ-01 |
CHOKO |
November 2012 |
January 2014 |
January 2014 |
May 5, 2014 |
May 5, 2014 |
|
- University of Helsinki
Helsinki, Helsingin Yliopisto, Finland - Institute of Clinical Medicine
Helsinki, Uusimaa, Finland
|
| 12 |
NCT03034291 |
Completed |
Cacao Consumption in Patients With Insulin Resistance |
|
- Dietary Supplement: Cacao 70%
- Dietary Supplement: White chocolate
|
Interventional |
Not Applicable |
- Universidad de Antioquia
- Instituto Colombiano para el Desarrollo de la Ciencia y la Tecnología (COLCIENCIAS)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in the insulin resistance index (HOMA-IR)
- Anthropometric measurement 1
- Anthropometric measurement 2
- (and 2 more...)
|
92 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT03034291 |
Cacao IV |
|
May 2012 |
December 2013 |
March 2014 |
January 27, 2017 |
January 30, 2017 |
|
|
| 13 |
NCT02237066 |
Withdrawn |
Understanding Angioplasty by the Chocolate PTA Balloon Catheter Compared to Conventional PTA Balloons Via OCT Imaging |
- Infrainguinal Peripheral Arterial Disease
|
- Device: Chocolate PTA Balloon Angioplasty
- Device: Standard PTA Balloon Angioplasty
|
Interventional |
Not Applicable |
- TriReme Medical, LLC
- University Hospitals Cleveland Medical Center
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Luminal Gain
- Dissection
- Hematoma
- Optimal PTA
|
0 |
All |
18 Years and older (Adult, Senior) |
NCT02237066 |
Chocolate OCT |
|
September 2014 |
March 2015 |
March 2015 |
September 11, 2014 |
March 19, 2015 |
|
- Case Medical Center
Cleveland, Ohio, United States - Cleveland Clinic
Cleveland, Ohio, United States
|
| 14 |
NCT02129127 |
Completed |
Drug-Coated Chocolate PTA Balloon in Patients With Peripheral Arterial Disease - The ENDURE Trial |
- Peripheral Vascular Disease
|
- Device: Paclitaxel Coated Chocolate Balloon Angioplasty
|
Interventional |
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Late Lumen Loss (LLL)
- Device Success
- Technical Success
- (and 4 more...)
|
67 |
All |
18 Years and older (Adult, Senior) |
NCT02129127 |
CLP004 |
ENDURE |
March 2014 |
June 2015 |
April 2017 |
May 2, 2014 |
April 14, 2017 |
|
- Universitats Herzzentrum Bad Krozingen
Bad Krozingen, Germany - Auckland City Hospital
Auckland, New Zealand
|
| 15 |
NCT00906763 |
Unknown † |
Effects of Chocolate on Motor Symptoms of Parkinson's Disease |
|
- Dietary Supplement: Chocolate
|
Interventional |
Not Applicable |
- Technische Universität Dresden
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- UPDRS part III
- Biogenic amines in blood
|
23 |
All |
18 Years and older (Adult, Senior) |
NCT00906763 |
EK284112008 |
ChocoPD |
May 2009 |
August 2010 |
October 2010 |
May 21, 2009 |
May 26, 2010 |
|
- Dresden University of Technology, Medical Faculty
Dresden, Germany
|
| 16 |
NCT00538083 |
Completed |
Cocoa and Endothelial Function in Adults With Elevated BMI |
|
|
Interventional |
Phase 1 |
- Griffin Hospital
- Centers for Disease Control and Prevention
- The Hershey Company
|
Other / U.S. Fed / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
- Endothelial Function(acute & sustained phase)
- Blood Pressure(acute and sustained phase), lipid profile(sustained), LDL oxidation(sustained), lipid hydroperoxide(sustained), CRP(sustained), blood glucose(sustained), body weight(sustained), waist circumference(sustained), endothelin(sustained)
|
45 |
All |
30 Years to 75 Years (Adult, Senior) |
NCT00538083 |
Griffin Hospital IRB 2005-12 |
Chocolate |
August 2005 |
|
May 2006 |
October 2, 2007 |
October 2, 2007 |
|
- Griffin Hospital
Derby, Connecticut, United States
|
| 17 |
NCT01749852 |
Completed |
Effect of Polyphenol-rich Dark Chocolate on Body Weight in Overweight and Obese Adults |
|
- Other: Polyphenol-rich Dark chocolate
- Other: Placebo Dark chocolate
|
Interventional |
Not Applicable |
- Queen Margaret University
- Barry Callebaut
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Change in Body weight
- Change in Body Fat percentage
- Change in Waist circumference
- Change in urinary Cortisol-to-cortisone ratio
|
14 |
All |
18 Years to 65 Years (Adult) |
NCT01749852 |
DC-BW 01 |
|
January 2013 |
July 2013 |
January 2014 |
December 17, 2012 |
October 21, 2014 |
|
- Queen Margaret University Lab
Musselburgh, East Lothian, United Kingdom
|
| 18 |
NCT01749020 |
Completed |
Effect of Polyphenol-rich Dark Chocolate on Insulin Sensitivity in Normal Weight and Overweight Adults |
|
- Other: Polyphenol-rich Dark chocolate
- Other: Placebo Dark chocolate
|
Interventional |
Not Applicable |
- Queen Margaret University
- Barry Callebaut
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Determine if the consumption of DC rich in polyphenols can induce a change in insulin sensitivity
- Determine if the consumption of DC rich in polyphenols can induce a change in glucose levels
- Determine if the consumption of DC rich in polyphenols can induce a change in Lipid profile (TC, HDL, LDL & TG)
- (and 5 more...)
|
61 |
All |
18 Years to 65 Years (Adult) |
NCT01749020 |
DC-Ins01 |
|
March 2012 |
July 2013 |
July 2013 |
December 13, 2012 |
November 20, 2013 |
|
- Queen Margaret University Lab
Musselburgh, East Lothian, United Kingdom
|
| 19 |
NCT01589042 |
Completed |
Chocolate Balloon Angioplasty Registry |
- Peripheral Arterial Disease
|
|
Observational |
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Achievement of Optimal PTA
|
490 |
All |
18 Years and older (Adult, Senior) |
NCT01589042 |
CLP782 |
Chocolate BAR |
May 2012 |
December 2015 |
|
May 1, 2012 |
June 3, 2016 |
|
- Arizona Heart Institute
Phoenix, Arizona, United States - Desert Cardiology
Rancho Mirage, California, United States - Cardiovascular Research of North Florida
Gainesville, Florida, United States - (and 10 more...)
|
| 20 |
NCT01099150 |
Completed |
Dark Chocolate and Platelet Function in Humans |
|
- Dietary Supplement: Dark chocolate enriched in flavan-3-ols and procyanidins
- Dietary Supplement: Standard dark chocolate
- Dietary Supplement: White chocolate
|
Interventional |
Not Applicable |
- University of Aberdeen
- Rural and Environment Research and Analysis Directorate (RERAD, UK)
- Biotechnology and Biological Sciences Research Council
- Natraceutical Industrial S.L.U., Valencia, Spain
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Prevention
|
- Change in light transmission aggregometry of platelet-rich plasma
- Change in ex vivo bleeding time using the Platelet Function Analyzer-100 (PFA-100)
- Change in P-selectin expression and activation of the fibrinogen receptor by flow cytometry
- (and 12 more...)
|
42 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT01099150 |
600
09/002 |
|
March 2009 |
November 2009 |
May 2011 |
April 6, 2010 |
April 17, 2012 |
|
- University of Aberdeen Rowett Institute of Nutrition and Health
Aberdeen, Aberdeenshire, United Kingdom
|
| 21 |
NCT03453073 |
Active, not recruiting |
Chocolate and CVD Risk in Postmenopausal Women |
- Cardiovascular Disease
- Heart Disease
- Stroke
|
- Behavioral: chocolate consumption level
- Other: physician diagnosis of first occurrence of serious chronic disease
|
Observational |
|
- Brooklyn College of the City University of New York
- National Heart, Lung, and Blood Institute (NHLBI)
- Department of Health and Human Services
|
Other / NIH / U.S. Fed |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
- incidence of heart disease
- incidence of stroke
- incidence of heart disease or stroke
- (and 4 more...)
|
83310 |
Female |
55 Years to 79 Years (Adult, Senior) |
NCT03453073 |
438347-3 |
|
December 15, 2014 |
April 30, 2018 |
April 30, 2018 |
March 5, 2018 |
March 5, 2018 |
|
|
| 22 |
NCT01314924 |
Completed |
Effects of Acute Ingestion of Dark Chocolate on Endothelial Function in Hypertensive Patients |
|
- Dietary Supplement: Dark chocolate
|
Interventional |
Phase 4 |
- Hospital Universitario Pedro Ernesto
- Rio de Janeiro State Research Supporting Foundation (FAPERJ)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Endothelial function
- Blood pressure
- Central hemodynamic parameters
|
21 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT01314924 |
CHOC-70 |
|
January 2011 |
August 2011 |
September 2011 |
March 15, 2011 |
January 11, 2012 |
|
- Hospital Universitario Pedro Ernesto
Rio de Janeiro, RJ, Brazil
|
| 23 |
NCT01918137 |
Unknown † |
The Effect of a Deep-fried Chocolate Bar or Porridge on Cerebral Blood Flow |
- Effect on Cerebrovascular Reactivity
|
- Dietary Supplement: chocolate bar
- Dietary Supplement: Porridge
|
Interventional |
Not Applicable |
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in breath hold index after ingestion of deep-fried chocolate bar compared with change after porridge ingestion
|
24 |
All |
18 Years to 40 Years (Adult) |
NCT01918137 |
GN13MT357 |
|
August 2013 |
September 2013 |
September 2013 |
August 7, 2013 |
August 7, 2013 |
|
- Western Infirmary
Glasgow, United Kingdom
|
| 24 |
NCT03214133 |
Active, not recruiting |
Effects of Epicatechin-rich Cocoa on Collagen Synthesis |
|
- Other: Epicatechin-rich cocoa dose response
- Other: Epicatechin-rich cocoa vs placebo on performance
|
Interventional |
Not Applicable |
- University of California, Davis
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Epicatechin-rich cocoa dose response
- Effect of the optimized dose of epicatechin-rich cocoa on performance
|
60 |
Male |
18 Years to 25 Years (Adult) |
NCT03214133 |
1020494 |
coca-dose |
May 23, 2017 |
March 15, 2019 |
March 15, 2019 |
July 11, 2017 |
March 26, 2018 |
|
- Neurobiology, Physiology & Behaviour
Davis, California, United States
|
| 25 |
NCT01408966 |
Completed |
Effects of Dark vs. White Chocolate on the Postprandial Increase in Portal Pressure in Cirrhosis |
- Cirrhosis
- Portal Hypertension
|
- Dietary Supplement: DarkChocolate
- Dietary Supplement: WhiteChocolate
|
Interventional |
Phase 2 |
- Hospital Clinic of Barcelona
- Instituto de Salud Carlos III
- Consorcio Centro de Investigación Biomédica en Red, M.P.
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Postprandial change in HVPG (% change and absolute change in mmHg)
- Post-prandial change in portal vein blood flow by US-Doppler
- Post-prandial change in nitric oxide metabolites
- (and 2 more...)
|
22 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT01408966 |
DarkChocolateinHTP2008 |
|
August 2008 |
October 2008 |
June 2009 |
August 3, 2011 |
August 3, 2011 |
|
- Hepatic Hemodynamic Laboratory. Liver Unit. Hospital Clinic.
Barcelona, Spain
|
| 26 |
NCT00661986 |
Completed |
Effect of Different Dosages of Dark Chocolate on Arterial Blood Pressure in Cardiovascular High-risk Patients |
|
- Dietary Supplement: dark chocolate 6 g/day
- Dietary Supplement: dark chocolate 25 g/day
|
Interventional |
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in mean ambulatory arterial blood pressure
- change in weight and BMI
- change in various lab parameters
|
102 |
All |
18 Years and older (Adult, Senior) |
NCT00661986 |
Leipzig chocolate |
|
February 2008 |
May 2009 |
May 2009 |
April 21, 2008 |
February 2, 2010 |
|
|
| 27 |
NCT01193764 |
Unknown † |
Study Assessing the Effect of Chocolate Consumption in Subjects With A History of Acne Vulgaris |
|
- Dietary Supplement: 100% cocoa powder
- Dietary Supplement: gelatin (Gelita)
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- development of acneiform lesions
|
24 |
Male |
18 Years to 35 Years (Adult) |
NCT01193764 |
20100520 - Intramural - Berman |
|
September 2010 |
March 2011 |
March 2011 |
September 2, 2010 |
September 2, 2010 |
|
- University of Miami
Miami, Florida, United States
|
| 28 |
NCT03195465 |
Active, not recruiting |
The Effect of High Antioxidant Cacao on Behaviors in Children With Autism Spectrum Disorder |
|
- Dietary Supplement: Dark Chocolate
|
Interventional |
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Aberrant Behavior Checklist
- Autism Spectrum Rating Scale
|
23 |
All |
5 Years to 18 Years (Child, Adult) |
NCT03195465 |
5170206 |
|
November 14, 2017 |
July 2018 |
July 2018 |
June 22, 2017 |
March 27, 2018 |
|
- Loma Linda University Health
Loma Linda, California, United States
|
| 29 |
NCT02876887 |
Recruiting |
Cocoa to Improve Walking Performance in Peripheral Artery Disease |
- Peripheral Artery Disease
|
|
Interventional |
Not Applicable |
- Northwestern University
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Six-minute walk performance
- Maximal and pain-free treadmill walking time
- Brachial artery flow-mediated dilation: change in brachial artery diameter
- (and 3 more...)
|
44 |
All |
60 Years and older (Adult, Senior) |
NCT02876887 |
STU00202741
R21AG050897 |
COCOA-PAD |
January 2017 |
June 2019 |
June 2019 |
August 24, 2016 |
June 20, 2017 |
|
- Northwestern University Feinberg School of Medicine
Chicago, Illinois, United States
|
| 30 |
NCT00538941 |
Completed |
Effects of Chocolate in Patients With Chronic Heart Failure |
|
- Dietary Supplement: Nestlé Noir intense 40 grx2
- Dietary Supplement: Nestlé Placebo Chocolate 40 grx2
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- endothelial function
- shear-stress dependent platelet function; Oxidative stress; baroreceptor function Systemic inflammatory response (assessed as change in high sensitivity CRP, 8-Isoprostanes, CD-40 ligand); Plasma epicatechins.
|
22 |
All |
30 Years to 80 Years (Adult, Senior) |
NCT00538941 |
EK1124_Chocolate_CHF |
|
November 2005 |
October 2009 |
October 2009 |
October 3, 2007 |
October 28, 2009 |
|
- Cardiovascular Center, Cardiology, University Hospital of Zurich
Zurich, Switzerland
|
| 31 |
NCT01496235 |
Terminated |
Effect of Cocoa Consumption in Cardiovascular and Immune Parameters |
|
- Dietary Supplement: Dark chocolate
- Dietary Supplement: White chocolate
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in diastolic blood pressure
- Change in systolic blood pressure
- Change in total cholesterol
- (and 8 more...)
|
69 |
All |
18 Years to 65 Years (Adult) |
NCT01496235 |
Cacao I |
|
July 2009 |
July 2011 |
July 2011 |
December 21, 2011 |
December 21, 2011 |
|
- Sede Investigaciones Universitarias, Universidad de Antioquia
Medellín, Antioquia, Colombia
|
| 32 |
NCT01671514 |
Completed |
Effects of Dark Chocolate on Exercise Capacity, and Mitochondrial Structure and Function |
- Heart Failure
- Type 2 Diabetes
|
- Dietary Supplement: Epicatechin-enriched dark chocolate
- Other: Low-epicatechin dark chocolate
|
Interventional |
Not Applicable |
- University of California, San Diego
- The Hershey Company
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
|
- Change from baseline in exercise capacity
- Change from baseline in skeletal muscle metabolism
- Change from baseline in pre-specified biomarker levels in blood, skeletal muscle, and urine
|
21 |
All |
40 Years to 70 Years (Adult, Senior) |
NCT01671514 |
UCSD IRB 111680 |
|
July 2012 |
December 2014 |
December 2014 |
August 23, 2012 |
June 3, 2015 |
|
- University of California, San Diego
La Jolla, California, United States
|
| 33 |
NCT00492713 |
Completed |
Polyphenol Bioavailability From Chocolate |
|
- Other: dark chocolate
- Other: Milk chocolate 1
- Other: Milk chocolate 2
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Basic Science
|
- AUC plasma polyphenols
- Tmax and Cmax of plasma polyphenols
- Plasma and urinary metabolite identification and quantification
|
18 |
All |
19 Years to 45 Years (Adult) |
NCT00492713 |
06.31.MET |
|
June 2007 |
September 2008 |
April 2012 |
June 27, 2007 |
March 29, 2013 |
|
- Nestle Research Center
Lausanne, Vaud, Switzerland
|
| 34 |
NCT02447770 |
Completed |
Effect of Long Term Cocoa Flavanol Intake on Blood Pressure and Platelet Function in Healthy Adults, Part 1 |
|
- Dietary Supplement: Mars Cocoa Extract Capsules
|
Interventional |
Not Applicable |
- University of California, Davis
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in blood pressure
- Change in platelet function
- Change in metabolic parameters in blood
- (and 2 more...)
|
37 |
All |
30 Years to 55 Years (Adult) |
NCT02447770 |
311497
311497-I |
|
May 2012 |
July 2012 |
July 2012 |
May 19, 2015 |
May 30, 2017 |
|
- Ragle Human Nutrition Research Center, Department of Nutrition at UC Davis
Davis, California, United States
|
| 35 |
NCT01444625 |
Completed |
Flavanols and Skin Photo Protection: a Clinical Trial |
|
- Other: Flavanol-rich chocolate
- Other: Flavanol-free chocolate
|
Interventional |
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Change in Minimal erythema dose
- Change in Skin elasticity
- Change in Skin moisture
- Change in levels of Vitamin D and polyphenols
|
78 |
Female |
20 Years to 65 Years (Adult) |
NCT01444625 |
Callebaut-10151 |
CHOCOPO |
June 2011 |
September 2012 |
May 2013 |
October 3, 2011 |
May 29, 2013 |
|
- Laval university, Department of Medicine, Institut des nutraceutiques et des aliments fonctionnels.
Québec, Quebec, Canada
|
| 36 |
NCT00513344 |
Completed
Has Results |
Efficacy of Polyphenols From Milk and Dark Chocolate |
|
- Dietary Supplement: Dark Chocolate
- Dietary Supplement: Milk Chocolate
- Dietary Supplement: Control (polyphenol-free) "Chocolate"
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Basic Science
|
- Change in Reactive Hyperemia Index (RHI) From Baseline (20 Min Before Product Intake) to 2 Hours Following Product Intake
- Change in Arterial Stiffness From Baseline (20 Min Before Product Intake) to Two Hours Following Product Intake
|
6 |
All |
25 Years to 45 Years (Adult) |
NCT00513344 |
06.38.MET |
|
June 2008 |
June 2009 |
April 2012 |
August 8, 2007 |
August 14, 2013 |
August 14, 2013 |
- Nestle Research Center
Lausanne, Vaud, Switzerland
|
| 37 |
NCT03305107 |
Recruiting |
High-intensity Interval Exercise and Chocolate Milk on Blood Glucose and Cognition |
- Glycemic Response
- Cognitive Function
|
- Other: Exercise and Chocolate Milk
- Other: Exercise and Water
- Other: Sitting and Chocolate Milk
- Other: Sitting and Water
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change from baseline Glycemic Response
- Change from baseline verbal declarative memory
- Change from baseline working memory
- (and 15 more...)
|
20 |
All |
9 Years to 13 Years (Child) |
NCT03305107 |
REB2017- 088 |
|
July 8, 2017 |
December 31, 2017 |
December 31, 2017 |
October 9, 2017 |
October 9, 2017 |
|
- School of Nutrition, Ryerson University
Toronto, Ontario, Canada
|
| 38 |
NCT01308892 |
Completed |
Cardiovascular Health Effects of Flavanol Rich Chocolate |
|
- Dietary Supplement: High flavanol chocolate
- Dietary Supplement: Low flavanol chocolate
- Dietary Supplement: High fat challenge
|
Interventional |
Not Applicable |
- Wageningen University
- Top Institute Food and Nutrition
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
|
- Blood pressure
- FMD
- PWA
- (and 5 more...)
|
44 |
Male |
45 Years to 70 Years (Adult, Senior) |
NCT01308892 |
NL33506.081.10 |
CHOC |
January 2011 |
June 2011 |
June 2011 |
March 4, 2011 |
June 17, 2011 |
|
- Wageningen universiteit division of human
Wageningen, Gelderland, Netherlands
|
| 39 |
NCT03022955 |
Completed |
Effects of Cocoa on Gastrointestinal Function |
- Gastrointestinal and Digestive Disorder
|
- Dietary Supplement: Dark chocolate bar
- Dietary Supplement: Dark chocolate mousse
- Dietary Supplement: White chocolate bar
- Dietary Supplement: White chocolate mousse
|
Interventional |
Not Applicable |
- University Hospital, Basel, Switzerland
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Gastric emptying half time
- Oro-caecal transit time (OCTT)
- Colonic transit time
- (and 2 more...)
|
16 |
All |
18 Years to 65 Years (Adult) |
NCT03022955 |
Chocolate Study |
|
January 2017 |
June 2017 |
June 2017 |
January 18, 2017 |
February 12, 2018 |
|
- St Claraspital
Basel, Switzerland
|
| 40 |
NCT03288155 |
Recruiting |
Can a Flavonoid-rich Pure Cocoa Reduce Fatigue in People With Parkinson's (PD) |
|
- Dietary Supplement: Cocoa
|
Interventional |
Not Applicable |
- Oxford Brookes University
- European Parkinson Therapy Centre
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Fatigue Numerical Scale (FNS)
- Adult Memory and Information Processing Battery (AMIPB)
- 6-Minute Walking Test
- (and 3 more...)
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03288155 |
OxfordBU |
|
July 1, 2017 |
January 1, 2019 |
January 1, 2019 |
September 19, 2017 |
September 20, 2017 |
|
- European Parkinson Therapy Centre
Boario, Terme, Italy
|
| 41 |
NCT02221791 |
Completed |
Comparison of Pure Epicatechin and Cocoa on Markers of Vascular Function |
- Endothelial Dysfunction
- Bioavailability
|
- Dietary Supplement: Pure Epicatechin
- Dietary Supplement: High flavan-3-ol cocoa
- Dietary Supplement: Placebo
|
Interventional |
Not Applicable |
- Wageningen University
- Top Institute Food and Nutrition
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Investigator)
- Primary Purpose: Basic Science
|
- Change in Endothelium-dependent flow-mediated dilation as a result of high flavan-3-ol cocoa or pure epicatechin consumption.
- Change in nitric oxide as a result of high flavan-3-ol cocoa or pure epicatechin consumption
- Changes in arterial augmentation index as measured by Pulse Wave Analysis
- (and 2 more...)
|
20 |
Male |
40 Years to 80 Years (Adult, Senior) |
NCT02221791 |
FLAVO2 |
FLAVO2 |
June 2014 |
October 2014 |
October 2014 |
August 20, 2014 |
October 15, 2014 |
|
- Wageningen University
Wageningen, Netherlands
|
| 42 |
NCT01947712 |
Completed |
Effect of Polyphenols on Peripheral Vascular Disease. |
- Peripheral Arterial Disease
|
- Dietary Supplement: dark chocolate with crossover to milk chocolate
- Dietary Supplement: milk chocolate with crossover to dark chocolate
|
Interventional |
Phase 1
Phase 2 |
- University of Roma La Sapienza
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- endothelial function assessed by flow mediated dilation (FMD)
- Oxidative stress markers
- Maximal walking distance
- Ankle Brachial Index (ABI)
|
20 |
All |
20 Years to 90 Years (Adult, Senior) |
NCT01947712 |
C26A12BPZN |
|
October 2010 |
August 2013 |
September 2013 |
September 20, 2013 |
September 20, 2013 |
|
- Sapienza University of Rome, I Clinica Medica, Research Tower
Rome, Italy
|
| 43 |
NCT00825695 |
Completed |
Flavanol-Rich Cocoa and Cerebral Blood Flow |
|
- Dietary Supplement: cocoa
|
Interventional |
Not Applicable |
- Brigham and Women's Hospital
- MasterFoods
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- functional transcranial doppler measures
|
60 |
All |
65 Years and older (Adult, Senior) |
NCT00825695 |
P-001936
1R01HL089570 |
|
January 2009 |
March 2012 |
June 2013 |
January 21, 2009 |
April 30, 2014 |
|
- Brigham and Women's Hospital
Boston, Massachusetts, United States
|
| 44 |
NCT01391624 |
Completed |
Study on the Possible Effects of Diet Supplementation With Essential Fatty Acids in Chocolate Craving Volunteers |
- Addictive Behavior
- Abstinence Syndrome
|
- Drug: Flaxseed oil
- Drug: Paraffin + # 2 dye
|
Interventional |
Phase 2
Phase 3 |
- Federal University of São Paulo
- Associação Fundo de Incentivo à Pesquisa
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Changes in the MBES score (used to quantify chocolate compulsion) from baseline.
|
30 |
All |
18 Years to 45 Years (Adult) |
NCT01391624 |
Omega3-chocolate-001 |
OMEGA3CHOCO |
August 2010 |
January 2011 |
January 2011 |
July 12, 2011 |
July 12, 2011 |
|
- Universidade Federal de São Paulo (Federal University of São Paulo); Departamento de Psicobiologia (Department of Psychobiology)
São Paulo, Brazil
|
| 45 |
NCT00553774 |
Completed |
Effect of Cocoa Flavanols on Vascular Function |
|
- Dietary Supplement: Cocoa Flavanols
- Other: Placebo
|
Interventional |
Phase 1 |
- University of California, San Francisco
- University of California, Davis
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Supportive Care
|
- An improvement of endothelial function as measured by flow-mediated dilation (FMD)
|
16 |
All |
18 Years to 100 Years (Adult, Senior) |
NCT00553774 |
CHR#H47369-28112 |
Cocoa |
March 2007 |
February 2008 |
February 2008 |
November 6, 2007 |
October 27, 2016 |
|
- University of California
San Francisco, California, United States
|
| 46 |
NCT01680484 |
Completed |
Bitter Chocolate or Orange Juice for Non-reactive Non-stress Test (NST) Patterns |
- Nonreassuring Fetal Status
|
- Dietary Supplement: Bitter chocolate
- Dietary Supplement: Orange juice
|
Interventional |
Not Applicable |
- Dr. Sami Ulus Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
|
- Increase in reactivity of NST
- Increase in the maternal fetal movement perception
|
180 |
Female |
18 Years to 45 Years (Adult) |
NCT01680484 |
HEK 10/117-13 |
|
February 2011 |
December 2011 |
January 2012 |
September 7, 2012 |
September 7, 2012 |
|
- Dr. Sami Ulus Maternity and Children's Training and Research Hospital
Ankara, Turkey
|
| 47 |
NCT01507259 |
Completed |
Chocolate's Effect on the Cerebral Vasculature |
|
|
Observational |
|
- NHS Greater Glasgow and Clyde
- University of Glasgow
|
Other |
- Observational Model: Case-Crossover
- Time Perspective: Prospective
|
|
24 |
All |
18 Years to 40 Years (Adult) |
NCT01507259 |
GN11MT497 |
|
February 2012 |
|
February 2012 |
January 10, 2012 |
July 27, 2012 |
|
- Western Infirmary
Glasgow, United Kingdom
|
| 48 |
NCT03035201 |
Enrolling by invitation |
COcoa Supplement and Multivitamin Outcomes Study for the Mind |
- Cognitive Impairment
- Dementia
- Aging
|
- Dietary Supplement: Cocoa extract
- Dietary Supplement: Multivitamin
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Institute on Aging (NIA)
- Brigham and Women's Hospital
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Cocoa extract effects on global cognitive trajectory
- Multivitamin effects on global cognitive trajectory
- Treatment effects on incident cognitive impairment
- Intervention effects on executive function and episodic memory
|
2000 |
All |
65 Years and older (Adult, Senior) |
NCT03035201 |
IRB 00037753
1R01AG050657-01A1 |
COSMOS-Mind |
September 2016 |
October 2020 |
October 2020 |
January 27, 2017 |
November 7, 2017 |
|
- Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
|
| 49 |
NCT02060097 |
Completed |
Effects of Cocoa Flavanol on Skin Aging |
|
- Dietary Supplement: Cocoa flavanol beverage
- Dietary Supplement: Placebo beverage
|
Interventional |
Not Applicable |
- Seoul National University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change from baseline in skin wrinkles at week 24
- Change from baseline in skin elasticity at week 24
- Change from baseline in minimal erythema dose at week 24
- (and 2 more...)
|
64 |
Female |
40 Years and older (Adult, Senior) |
NCT02060097 |
N0000697 |
|
February 2014 |
March 2015 |
March 2015 |
February 11, 2014 |
June 14, 2016 |
|
- Seoul National University Hospital
Seoul, Korea, Republic of
|
| 50 |
NCT01886989 |
Completed |
Cocoa Polyphenols and Postprandial Metabolism in Type 2 Diabetes |
|
- Dietary Supplement: Cocoa polyphenols
|
Interventional |
Not Applicable |
- Arpita Basu
- Oklahoma State University
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Blood pressure (mm Hg)
- Glucose (mg/dL)
- Blood lipids
- Inflammation
|
18 |
All |
21 Years to 60 Years (Adult) |
NCT01886989 |
HE-12-52 |
|
January 2012 |
December 2014 |
December 2014 |
June 26, 2013 |
January 23, 2018 |
|
- Department of Nutritional Sciences
Stillwater, Oklahoma, United States
|
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