Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
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5837 studies found for:    c1 inhibitor

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1 Completed A Study to Evaluate the Clinical Pharmacology and Safety of C1-esterase Inhibitor Administered by the Subcutaneous Route
Condition: Hereditary Angioedema Types I and II
Interventions: Biological: C1-esterase inhibitor - single intravenous dose;   Biological: C1-esterase inhibitor - subcutaneous low dose;   Biological: C1-esterase inhibitor - subcutaneous medium dose;   Biological: C1-esterase inhibitor - subcutaneous high dose
2 Completed In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia
Conditions: Endotoxemia;   Inflammation;   Multi Organ Dysfunction Syndrome
Interventions: Drug: C1-esterase inhibitor;   Drug: Endotoxin administration
3 Completed Berinert P Study of Subcutaneous Versus Intravenous Administration
Condition: Hereditary Angioedema
Intervention: Drug: C1-Esterase Inhibitor
4 Completed Safety & Tolerability of Berinert® (C1 Inhibitor) Therapy to Prevent Rejection
Condition: Kidney Transplantation
Intervention: Biological: C1 Esterase Inhibitor
5 Terminated Effect of C1-esterase Inhibitor on Systemic Inflammation in Trauma Patients With a Femur or Pelvic Fracture
Conditions: Trauma;   Inflammation;   Sepsis;   Multiple Organ Dysfunction Syndrome
Interventions: Drug: C1-esterase inhibitor;   Other: Saline 0.9%
6 Completed Patient Registry Study of Berinert® in Normal Clinical Practice
Condition: Includes: Hereditary Angioedema
Intervention: Biological: Berinert® (C1 Esterase Inhibitor)
7 Completed A Study to Evaluate the Safety and Pharmacokinetics of Two Formulations of C1-esterase Inhibitor
Condition: Hereditary Angioedema Types I and II
Interventions: Biological: Berinert;   Biological: CSL830
8 Recruiting C1INH Inhibitor Preoperative and Post Kidney Transplant to Prevent DGF & IRI
Conditions: End Stage Renal Disease;   Kidney Failure;   Delayed Graft Function;   Ischemic Reperfusion Injury
Interventions: Drug: C1 Esterase Inhibitor;   Drug: Placebo
9 Completed
Has Results 		C1 Esterase Inhibitor in Hereditary Angioedema (HAE)(Extension Study)
Condition: Hereditary Angioedema
Intervention: Drug: C1 Esterase Inhibitor
10 Completed
Has Results 		Human C1 Esterase Inhibitor (C1-INH) in Subjects With Acute Abdominal or Facial Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Interventions: Biological: C1 Esterase Inhibitor;   Biological: Placebo
11 Completed
Has Results 		Open-Label C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Intervention: Biological: C1 esterase inhibitor [human] (C1INH-nf)
12 Completed In Vivo Effects of C1-esterase Inhibitor on the Innate Immune Response During Human Endotoxemia - VECTOR II
Conditions: Innate Immune Response;   Endotoxemia;   Inflammation;   Sepsis
Interventions: Drug: C1-esterase inhibitor;   Drug: Endotoxin
13 Completed
Has Results 		C1 Esterase Inhibitor (C1INH-nf) for the Prevention of Acute Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Interventions: Biological: C1 esterase inhibitor [human] (C1INH-nf);   Drug: Placebo (saline)
14 Completed
Has Results 		C1 Esterase Inhibitor (C1INH-nf) for the Treatment of Acute Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Interventions: Biological: C1 esterase inhibitor [human] (C1INH-nf);   Drug: Placebo (saline)
15 Recruiting A Study to Evaluate the Clinical Efficacy and Safety of Subcutaneously Administered C1-esterase Inhibitor in the Prevention of Hereditary Angioedema
Condition: Hereditary Angioedema Types I and II
Interventions: Biological: Low-volume C1-esterase inhibitor;   Biological: Higher-volume C1-esterase inhibitor;   Biological: Low-volume placebo;   Biological: Higher-volume placebo
16 Completed
Has Results 		Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Conditions: Hereditary Angioedema;   Angioneurotic Edema
Interventions: Drug: Recombinant Human C1 Inhibitor;   Drug: placebo
17 Completed
Has Results 		CINRYZE for the Treatment of Hereditary Angioedema Attacks in Children Under the Age of 12
Condition: Hereditary Angioedema
Intervention: Biological: CINRYZE
18 Completed
Has Results 		Recombinant Human C1 Inhibitor for the Treatment of Acute Attacks in Patients With Hereditary Angioedema
Conditions: Hereditary Angioedema;   Angioneurotic Edema;   Genetic Disorders
Interventions: Drug: recombinant human C1 inhibitor;   Drug: Placebo
19 Recruiting C1 Inhibitor Registry in the Treatment of Hereditary Angioedema (HAE) Attacks
Condition: Hereditary Angioedema
Intervention: Drug: rhC1INH or pdC1INH
20 Completed Postmarketing Immunogenicity Study in HAE Subjects Treated With Berinert
Condition: Hereditary Angioedema Types I and II
Intervention: Biological: Berinert, lyophilisate for IV application containing 500 units (U) C1-INH to be reconstituted with 10 mL water for injection
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† Indicates status has not been verified in more than two years