1 |
NCT03036397 |
Recruiting |
Effects of SRX246, a Vasopressin Receptor (V1a) Antagonist, on an Experimental Model of Fear and Anxiety in Humans |
|
- Drug: SRX246
- Drug: Placebo
|
Interventional |
Phase 1 |
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Fear and anxiety potentiated startle
- Skin conductance
- Subjective Anxious Mood
- (and 2 more...)
|
47 |
All |
21 Years to 50 Years (Adult) |
NCT03036397 |
170046 17-M-0046 |
|
March 3, 2017 |
December 31, 2018 |
December 31, 2019 |
January 30, 2017 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
2 |
NCT02153944 |
Recruiting |
Cognitive vs. Emotional Psychopharmacological Manipulations of Fear vs. Anxiety |
|
- Drug: Propanolol
- Drug: Methylphenidate
|
Interventional |
Phase 3 |
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- Will the reduction of induced-anxiety with propranolol improve cognitive performance.
- Will the facilitation of cognitive performance with methylphenidate reduce induced-anxiety.
|
234 |
All |
18 Years to 50 Years (Adult) |
NCT02153944 |
140114 14-M-0114 |
|
May 31, 2014 |
March 8, 2019 |
March 8, 2019 |
June 3, 2014 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
3 |
NCT00055224 |
Recruiting |
Expectation of Unpleasant Events in Anxiety Disorders |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
1271 |
All |
18 Years to 50 Years (Adult) |
NCT00055224 |
030093 03-M-0093 |
|
February 20, 2003 |
|
|
February 21, 2003 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
4 |
NCT01912287 |
Recruiting |
GATE: Generalized Anxiety - A Treatment Evaluation |
- Generalized Anxiety Disorder
|
- Behavioral: Cognitive Behavioral Therapy
- Behavioral: Stress Education
- Behavioral: Yoga
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Center for Complementary and Integrative Health (NCCIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Treatment Response as Assessed by the Clinical Global Impression-Improvement (CGI-I of 1 or 2) scale
- Structured Interview Guide for the Hamilton Anxiety Rating Scale (SIGH-A)
|
230 |
All |
18 Years and older (Adult, Senior) |
NCT01912287 |
2013P000048 1R01AT007258-01A1 |
|
December 2013 |
March 31, 2019 |
March 31, 2019 |
July 31, 2013 |
March 22, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Boston University
Boston, Massachusetts, United States
|
5 |
NCT03283930 |
Recruiting |
ABMT Augmentation of CBT |
- Anxiety Disorders
- Children, Only
|
- Behavioral: Active Attention Bias Modification Training
- Behavioral: Placebo Attention Bias Modification Training
|
Interventional |
Not Applicable |
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Pediatric Anxiety Rating Scale (PARS)
- Clinical Global Impression Scale (CGI)
|
120 |
All |
8 Years to 17 Years (Child) |
NCT03283930 |
0192A |
|
February 1, 2017 |
January 2021 |
January 2021 |
September 14, 2017 |
September 14, 2017 |
|
- NIH Clinical Center
Bethesda, Maryland, United States
|
6 |
NCT02818751 |
Recruiting |
Neurofunctional Predictors of Escitalopram Treatment Response in Adolescents With Anxiety |
|
- Drug: Escitalopram
- Other: Placebo
|
Interventional |
Not Applicable |
- University of Cincinnati
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Early escitalopram-related functional brain activity changes during emotional processing
- Change in functional activity in the ventrolateral prefrontal cortex (from baseline to week 2) and improvement in Pediatric Anxiety Rating Scale score (at week 8/early termination)
- Change in functional connectivity between the ventrolateral prefrontal cortex and the amygdala (from baseline to week 2) and improvement in Pediatric Anxiety Rating Scale score (at week 8/early termination)
- (and 2 more...)
|
84 |
All |
12 Years to 17 Years (Child) |
NCT02818751 |
Strawn FiESTAA K23MH106037 |
FiESTAA |
May 2015 |
May 2019 |
May 2020 |
June 30, 2016 |
March 27, 2018 |
|
- University of Cincinnati, Department of Psychiatry & Behavioral Neuroscience
Cincinnati, Ohio, United States
|
7 |
NCT02365870 |
Recruiting |
Anxiety in Parkinson's: Use of Quantitative Methods to Guide Rational Treatment |
- Anxiety Disorders
- Parkinson Disease
|
- Drug: rotigotine transdermal patch
- Drug: placebo
|
Interventional |
Phase 4 |
- Johns Hopkins University
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hamilton Anxiety Rating Scale
- 17-item Hamilton Depression Rating Scale
|
60 |
All |
21 Years to 89 Years (Adult, Senior) |
NCT02365870 |
K23AG044441 1K23AG044441-01A1 |
ANXPD |
August 2016 |
December 2018 |
January 2019 |
February 19, 2015 |
December 7, 2017 |
|
- Johns Hopkins University School of Medicine
Baltimore, Maryland, United States
|
8 |
NCT00024635 |
Recruiting |
Evaluation of Patients With Mood and Anxiety Disorders and Healthy Volunteers |
- Mood Disorder
- Anxiety Disorder
- Healthly Volunteers
- (and 2 more...)
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- Suburban Hospital
- National Institutes of Health Clinical Center (CC)
|
NIH / Other |
- Observational Model: Cohort
- Time Perspective: Other
|
|
16000 |
All |
3 Years to 99 Years (Child, Adult, Senior) |
NCT00024635 |
010254 01-M-0254 |
|
September 21, 2001 |
|
|
April 29, 2005 |
October 19, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
9 |
NCT03382093 |
Recruiting |
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity |
- Anxiety Disorders
- Anxiety
- Tobacco Dependence
- (and 2 more...)
|
- Behavioral: Personalized Feedback Intervention
- Behavioral: Smoking Information Control
|
Interventional |
Not Applicable |
- University of Houston
- National Institute on Drug Abuse (NIDA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Evaluate PFI
- Smoking Motivational Processes
- Smoking Behavior
- (and 3 more...)
|
130 |
All |
18 Years to 65 Years (Adult) |
NCT03382093 |
CR00000267 5F31DA043390-02 |
|
August 23, 2017 |
December 2018 |
December 2018 |
December 22, 2017 |
December 22, 2017 |
|
- Anxiety and Health Research Laboratory and Substance Use Treatment Clinic, University of Houston
Houston, Texas, United States
|
10 |
NCT02063828 |
Recruiting |
Reducing Lung Cancer Survivors' Anxiety and Dyspnea (RELAX) |
|
- Device: Group A - Device guided breathing low dose
- Device: Group B - Device guided breathing high dose
- Device: Group C - Usual Breathing Control Group
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Change from baseline HADS- Anxiety Assessed 4 weeks post-randomization
- Change from 4 weeks HADS-Anxiety at 8 weeks
|
75 |
All |
18 Years and older (Adult, Senior) |
NCT02063828 |
REBACCCWFU 01213 U10CA081851 |
RELAX |
January 2, 2015 |
December 2018 |
June 2019 |
February 14, 2014 |
January 3, 2018 |
|
- Via Christi Hospitals, Wichita
Wichita, Kansas, United States - Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States - Greenville Health System NCORP
Greenville, South Carolina, United States - (and 2 more...)
|
11 |
NCT02156531 |
Recruiting |
Cognitive Bias Modification for Youth Anxiety |
|
- Behavioral: Self-Administered, Active Cognitive Bias Modification (CBM)
- Behavioral: Self-Administered, minimally effective attention-control version of the CBM program
|
Interventional |
Not Applicable |
- Kaiser Permanente
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Clinical effectiveness
- Cost Effectiveness
|
498 |
All |
12 Years to 17 Years (Child) |
NCT02156531 |
1R01MH101118-01A1 |
TeenCBM |
September 2014 |
May 2018 |
May 2019 |
June 5, 2014 |
April 28, 2017 |
|
- Kaiser Permanente Center for Health Research
Portland, Oregon, United States
|
12 |
NCT00071786 |
Recruiting |
Family Study of Affective and Anxiety Spectrum Disorders |
- Mood Disorders
- Anxiety Disorders
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
3975 |
All |
up to 60 Years (Child, Adult) |
NCT00071786 |
030211 03-M-0211 |
|
October 30, 2003 |
|
|
October 31, 2003 |
April 11, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
13 |
NCT03056872 |
Not yet recruiting |
Stress Reactivity as a Determinant in Co-occurring Alcohol Use and Anxiety Disorder: Diagnosis and Alcohol Use Outcomes |
- Alcohol Use Disorder
- Anxiety Disorder/Anxiety State
- Stress Disorder
- (and 2 more...)
|
|
Observational |
|
- University of Minnesota - Clinical and Translational Science Institute
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Relapse Status
- Relapse Severity
|
120 |
All |
18 Years to 65 Years (Adult) |
NCT03056872 |
1K01AA024805 |
|
March 2018 |
April 2022 |
April 2022 |
February 17, 2017 |
February 2, 2018 |
|
|
14 |
NCT03445143 |
Not yet recruiting |
GATE: Generalized Anxiety - A Treatment Evaluation |
- Generalized Anxiety
- Generalized Anxiety Disorder
|
- Behavioral: 12 Week Kundalini Yoga Practices
- Behavioral: Stress Education (SE)
- Behavioral: 12 session CBT treatment
|
Interventional |
Not Applicable |
- New York University School of Medicine
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Response Clinician Global Impression Improvement Scale (CGI-I)
- State Trait Anxiety Inventory (STAI)
- Perceived stress Scale (PSS)
- (and 7 more...)
|
60 |
All |
18 Years to 95 Years (Adult, Senior) |
NCT03445143 |
17-00526 |
|
June 2018 |
June 2021 |
June 2021 |
February 26, 2018 |
February 26, 2018 |
|
- New York University School of Medicine
New York, New York, United States
|
15 |
NCT00026559 |
Recruiting |
Effects of Arousal and Stress in Anxiety |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
1427 |
All |
18 Years to 50 Years (Adult) |
NCT00026559 |
010185 01-M-0185 |
|
June 27, 2001 |
|
|
November 12, 2001 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
16 |
NCT00397111 |
Recruiting |
Development of Magnetic Resonance Imaging Techniques for Studying Mood and Anxiety Disorders |
- Depressive Disorder, Major
- Bipolar Disorder
- Panic Disorder
- Stress Disorders, Post-Traumatic
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
|
340 |
All |
18 Years to 65 Years (Adult) |
NCT00397111 |
070021 07-M-0021 |
|
November 6, 2006 |
|
|
November 8, 2006 |
April 20, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
17 |
NCT02922166 |
Recruiting |
Effects of SRX246 on an Experimental Model of Fear and Anxiety in Humans |
|
- Drug: SRX246
- Drug: Placebo
|
Interventional |
Phase 1 |
- Azevan Pharmaceuticals
- National Institute of Mental Health (NIMH)
|
Industry / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in startle reflex between SRX246 and Placebo
- Change in emotional expression recognition between SRX246 and Placebo
- Change in State Anxiety Scale between SRX246 and Placebo
|
47 |
All |
21 Years to 50 Years (Adult) |
NCT02922166 |
AVN012 T-M-1970 |
|
February 3, 2017 |
December 2017 |
December 2018 |
October 4, 2016 |
February 9, 2017 |
|
- National Institute of Mental Health
Bethesda, Maryland, United States
|
18 |
NCT03027414 |
Recruiting |
Effect of Transcranial Magnetic Stimulation to the Dorsolateral Prefrontal Cortex on Anxiety Potentiated Startle |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- The primary objective of this study is to determine whether strengthening activity in the dlPFC with TMS will reduce anxiety either alone (during NPU) or during a low load cognitive task(Sternberg WM).
|
184 |
All |
18 Years to 50 Years (Adult) |
NCT03027414 |
170042 17-M-0042 |
|
January 12, 2017 |
January 1, 2023 |
January 1, 2023 |
January 23, 2017 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
19 |
NCT02807480 |
Recruiting |
Approach-Avoidance Conflict-a Multi-level Predictor for Therapy Response |
- Generalized Anxiety Disorder
|
- Behavioral: Exposure-based therapy
- Behavioral: Behavioral Activation therapy
- Behavioral: Computer-based behavioral assessment
- (and 3 more...)
|
Interventional |
Not Applicable |
- Laureate Institute for Brain Research, Inc.
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- For Aim1: Baseline generalized anxiety disorder symptoms as measured by the Generalized Anxiety Disorder - 7 item scale (GAD-7).
- For Aims 2 and 3: Change in generalized anxiety disorder symptoms as measured by the Generalized Anxiety Disorder - 7 item scale (GAD-7).
- Change in anxiety symptoms as measured by the Patient Reported Outcomes Measurement Information System (PROMIS) Anxiety Scale.
- (and 4 more...)
|
100 |
All |
18 Years to 55 Years (Adult) |
NCT02807480 |
2015-006-02 1K23MH108707-01A1 |
|
June 2016 |
April 2021 |
April 2021 |
June 21, 2016 |
June 28, 2017 |
|
- Laureate Institute for Brain Research
Tulsa, Oklahoma, United States
|
20 |
NCT02206945 |
Recruiting |
Neurofeedback for Obsessive-Compulsive Disorder (OCD) |
- Obsessive-Compulsive Disorder
|
- Behavioral: neurofeedback
- Behavioral: control feedback
|
Interventional |
Not Applicable |
- Yale University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- A modified version of the Yale-Brown Obsessive-Compulsive Symptom scale (Y-BOCS) will be used, that queries subjects regarding symptoms
- Control over target brain area
- Control over the target brain area.
|
54 |
All |
18 Years to 65 Years (Adult) |
NCT02206945 |
0206017435-2 R01MH100068 |
|
July 2015 |
May 2019 |
July 2019 |
August 1, 2014 |
February 6, 2018 |
|
- Yale University School of Medicine
New Haven, Connecticut, United States
|
21 |
NCT03168971 |
Recruiting |
Managing Anxiety From Cancer (MAC): Testing an Intervention for Anxiety in Older Adults With Cancer and Their Caregivers |
- Anxiety
- Depression
- Quality of Life
|
- Behavioral: Managing Anxiety from Cancer (MAC)
|
Interventional |
Not Applicable |
- Weill Medical College of Cornell University
- National Institute on Aging (NIA)
- American Federation for Aging Research
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Anxiety sub-scale of the Hospital Anxiety and Depression Scale
- Hamilton Anxiety Rating Scale
- Depression sub-scale of the Hospital Anxiety and Depression Scale
- (and 4 more...)
|
80 |
All |
65 Years and older (Adult, Senior) |
NCT03168971 |
1610017645 5K23AG048632 |
|
July 13, 2017 |
May 1, 2019 |
June 1, 2019 |
May 30, 2017 |
November 8, 2017 |
|
- Weill Medical College of Cornell University
New York, New York, United States
|
22 |
NCT02810171 |
Recruiting |
Dimensional Brain Behavior Predictors of CBT Outcomes in Pediatric Anxiety |
- Anxiety Disorders
- Social Anxiety Disorder
- Social Phobia
- (and 8 more...)
|
- Behavioral: Cognitive Behavioral Therapy
- Behavioral: Relaxation Therapy
|
Interventional |
Not Applicable |
- University of Michigan
- University of Illinois at Chicago
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Brain function/structure as assessed by Magnetic Resonance Imaging scans
- Pediatric Anxiety Rating Scale
|
280 |
All |
7 Years to 17 Years (Child) |
NCT02810171 |
HUM00118950 R01MH107419 |
Anxiety-CBT |
December 2016 |
June 2021 |
June 2021 |
June 22, 2016 |
February 1, 2018 |
|
- University of Michigan
Ann Arbor, Michigan, United States
|
23 |
NCT02423044 |
Recruiting |
Spatial Context and Fear Learning |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The primary objective is to investigate the neural bases of contextual fear learning measures by the event-related hemodynamic response (fMRI).
- The secondary objective is to see learning of the contextual fear response that will be measured by psychophysiological responses such as SCR, heart rate, pupil dilatation, and breathing.
|
82 |
All |
18 Years to 50 Years (Adult) |
NCT02423044 |
150114 15-M-0114 |
|
April 18, 2015 |
January 4, 2019 |
January 4, 2019 |
April 22, 2015 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
24 |
NCT03428490 |
Not yet recruiting |
Treatment for Comorbid Social Anxiety and Alcohol Use Disorders. |
- Alcohol Use Disorder
- Social Anxiety Disorder
|
- Behavioral: Fully integrated treatment
- Behavioral: Stand-alone Intensive Outpatient Program
|
Interventional |
Not Applicable |
- University of California, Los Angeles
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Matrix Institute on Addictions
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Alcohol consumption at 3 and 6 months
- Change from Baseline Social Anxiety Symptoms in Situations at 3 and 6 months
- Change from Baseline Social anxiety-related drinking motives at 3 and 6 months
- (and 6 more...)
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT03428490 |
SOCANX1 1R34AA025364-01 |
FIT |
March 15, 2018 |
April 30, 2020 |
April 30, 2020 |
February 9, 2018 |
February 12, 2018 |
|
- Matrix Institute on Addictions
Los Angeles, California, United States
|
25 |
NCT00018057 |
Recruiting |
Clinical Trial of Fluoxetine in Anxiety and Depression in Children, and Associated Brain Changes |
- Depression
- Mood Disorder
- Anxiety Disorder
- Healthy
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- University of Minnesota - Clinical and Translational Science Institute
- University of Oregon
- (and 2 more...)
|
NIH / Other |
|
- The Pediatric Anxiety Rating Scale (PARS)
- Clinical Global Impression Scale (CGI)
|
2530 |
All |
8 Years to 40 Years (Child, Adult) |
NCT00018057 |
010192 01-M-0192 |
|
June 27, 2001 |
|
|
July 2, 2001 |
March 21, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
26 |
NCT03118752 |
Recruiting |
Pragmatic Collaborative Care for Cardiac Inpatients With Depression or Anxiety |
- Acute Coronary Syndrome
- Heart Failure
- Depression
- (and 2 more...)
|
- Behavioral: Collaborative Care
|
Interventional |
Not Applicable |
- Massachusetts General Hospital
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in physical function
- Change in generic health-related quality of life
- Change in disease-specific health-related quality of life
- (and 12 more...)
|
260 |
All |
18 Years and older (Adult, Senior) |
NCT03118752 |
2016P002870 1R01HL133149-01A1 |
|
October 16, 2017 |
September 30, 2022 |
September 30, 2022 |
April 18, 2017 |
April 4, 2018 |
|
- Massachusetts General Hospital
Boston, Massachusetts, United States - Salem Hospital
Salem, Massachusetts, United States
|
27 |
NCT01570426 |
Recruiting |
Brain Imaging and Computer Games in Children With Either Bipolar Disorder, ADHD, Anxiety or Healthy Controls |
- Bipolar Disorder
- Attention Deficit Disorder With Hyperactivity
- Attention Deficit Disorder Without Hyperactivity
- (and 2 more...)
|
|
Observational |
|
- Bradley Hospital
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Behavioral performance on computerized tasks
- MRI data (neural activation) during behavioral task
- Genetic material
|
240 |
All |
7 Years to 17 Years (Child) |
NCT01570426 |
0195-07 K22MH074945 |
BBPP |
July 2007 |
December 2018 |
December 2018 |
April 4, 2012 |
January 18, 2018 |
|
- Bradley Hospital
East Providence, Rhode Island, United States
|
28 |
NCT01956344 |
Recruiting |
Neural Mechanisms of CBT Response in Hoarding Disorder |
- Obsessive Compulsive Disorder
|
- Behavioral: Cognitive Behavioral Therapy
|
Interventional |
Not Applicable |
- Hartford Hospital
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Saving Inventory-Revised (SI-R)
- Clinician Global Impression (CGI) Severity (Self Report and Clinician Administered)
|
120 |
All |
20 Years to 60 Years (Adult) |
NCT01956344 |
1R01MH101163-01 |
|
July 2013 |
June 2018 |
June 2018 |
October 8, 2013 |
March 14, 2018 |
|
- Anxiety Disorders Center, Institute of Living
Hartford, Connecticut, United States
|
29 |
NCT02651402 |
Recruiting |
A Hybrid Effectiveness-Implementation Trial of Group CBT in Urban Schools |
|
- Behavioral: FRIENDS for Life
- Behavioral: Adapted FRIENDS
- Behavioral: Train-the-Trainer
- Behavioral: Train-the-Trainer Plus
|
Interventional |
Not Applicable |
- Children's Hospital of Philadelphia
- University of Pennsylvania
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change in Anxiety Disorder Interview Schedule for Children (ADIS-P) from Baseline to Post Intervention
- Change in Children's Global Assessment Scale (CGAS) from Baseline to Post Intervention
- Cost Effectiveness
|
534 |
All |
8 Years to 99 Years (Child, Adult, Senior) |
NCT02651402 |
15-012311 1R01MH108555-01 |
|
February 2016 |
November 2020 |
November 2020 |
January 11, 2016 |
January 11, 2018 |
|
- Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
|
30 |
NCT00047853 |
Recruiting |
Brain Changes in Fear |
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
1600 |
All |
18 Years to 50 Years (Adult) |
NCT00047853 |
020321 02-M-0321 |
|
October 15, 2002 |
|
|
October 23, 2002 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
31 |
NCT03119272 |
Recruiting |
Microbiome-mediated Weight, Anxiety, and Stress Dysregulation in Anorexia Nervosa |
|
|
Observational |
|
- University of North Carolina, Chapel Hill
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Perfect total fat as it relates to each taxa (percentage abundance from phylum to the genus level) and their association with weight.
- Anxiety level (as measured by the State-Trait Anxiety Inventory) as it relates to each taxa (percentage abundance from phylum to the genus level).
- Stress level (as measured by the Perceived Stress Scale) as it relates to taxa (percentage abundance from phylum to the genus level).
|
200 |
Female |
15 Years to 45 Years (Child, Adult) |
NCT03119272 |
15-2133 1R01MH105684-01A1 |
Microbiome |
April 2016 |
December 2018 |
December 2018 |
April 18, 2017 |
April 18, 2017 |
|
- University of North Carolina at Chapel Hill
Chapel Hill, North Carolina, United States
|
32 |
NCT03318666 |
Recruiting |
Supporting Our Valued Adolescents Pilot Randomized Controlled Trial |
|
- Behavioral: Supporting Our Valued Adolescents (SOVA)
- Other: Enhanced Usual Care
|
Interventional |
Not Applicable |
- University of Pittsburgh
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Care Provider, Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Study retention
- Intervention acceptability
- Health beliefs: Stigma
- (and 23 more...)
|
300 |
All |
14 Years to 19 Years (Child, Adult) |
NCT03318666 |
PRO17070601 1K23MH111922-01A1 |
SOVA |
April 17, 2018 |
April 2019 |
August 2019 |
October 24, 2017 |
April 20, 2018 |
|
- Center for Adolescent and Young Adult Health
Pittsburgh, Pennsylvania, United States
|
33 |
NCT02633267 |
Recruiting |
1/2 A Multi-site Systems Intervention for Unemployed Persons With Social Anxiety |
|
- Behavioral: Vocational Services as usual plus Cognitive Behavioral Therapy (CBT)
- Behavioral: Usual Vocational Services
|
Interventional |
Not Applicable |
- University of Michigan
- University of California, Los Angeles
- National Institutes of Health (NIH)
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Liebowitz Social Anxiety Scale
- Patient Health Questionnaire
- Hours worked per week
|
300 |
All |
18 Years to 60 Years (Adult) |
NCT02633267 |
1R01MH102263-01A1 |
|
January 2016 |
January 2019 |
May 2019 |
December 17, 2015 |
April 20, 2018 |
|
- University of Michigan
Ann Arbor, Michigan, United States
|
34 |
NCT03354975 |
Recruiting |
Experiential Training for Community Therapists |
|
- Behavioral: Experiential Training
- Behavioral: Training-As-Usual
|
Interventional |
Not Applicable |
- Temple University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change from baseline Therapist Beliefs about Exposure Scale (TBES) at 3-month follow-up
- Change from baseline Exposure Therapy Clinical Use Survey (ETCUS) at 3-month follow-up
|
40 |
All |
18 Years and older (Adult, Senior) |
NCT03354975 |
260359 F31MH112211 |
|
March 23, 2018 |
July 1, 2018 |
November 1, 2018 |
November 28, 2017 |
March 27, 2018 |
|
- Temple University
Philadelphia, Pennsylvania, United States
|
35 |
NCT02421315 |
Recruiting |
Overlapping Neural Circuits in Pediatric OCD |
- Obsessive Compulsive Disorder
|
- Behavioral: Exposure & Response Prevention (EX/RP) and when indicated medication treatment
|
Interventional |
Not Applicable |
- New York State Psychiatric Institute
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change from baseline in brain activation (fMRI) after therapy
- Change from baseline in fractional anisotropy (Diffusion tensor imaging) after therapy
- Probabilistic Go/No-go reinforcement learning task
- (and 2 more...)
|
80 |
All |
5 Years to 17 Years (Child) |
NCT02421315 |
7006 R21MH101441 |
|
October 2014 |
May 2018 |
May 2018 |
April 20, 2015 |
February 14, 2018 |
|
- NY State Psychiatric Institute
New York, New York, United States
|
36 |
NCT03060096 |
Not yet recruiting |
Stepped-Care Telehealth for Distress in Rural Cancer Survivors |
- Anxiety
- Depressive Symptoms
- Sleep Disturbance
- (and 4 more...)
|
- Other: Severe Anxiety/depression: High Intensity Stepped Care
- Other: Moderate Anxiety/depression: Low Intensity Stepped care
- Other: Moderate Anxiety/depression: Enhanced Usual Care Control
- Other: Severe Anxiety/depression: Enhanced Usual Care Control Group
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Supportive Care
|
- Feasibility of study intervention measured by recruitment rate
- Feasibility of study intervention measured by accrual rate
- Feasibility of study intervention measured by adherence to intervention
- (and 11 more...)
|
120 |
All |
18 Years and older (Adult, Senior) |
NCT03060096 |
IRB00036687 1R21CA198237 |
Telehealth |
April 2018 |
March 31, 2019 |
March 31, 2019 |
February 23, 2017 |
March 8, 2018 |
|
|
37 |
NCT03190291 |
Not yet recruiting |
A Stepped-Care Telehealth Approach To Treat Distress In Rural Cancer Survivors |
|
- Behavioral: Stepped Care: Low Intensity
- Other: Enhanced Usual Care
- Behavioral: Stepped Care: High Intensity
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- National Cancer Institute (NCI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient Health Questionnaire-2 (PHQ-2)
- Generalized Anxiety Disorder-1 (GAD-1)
- Telephone Interview of Cognitive Status-modified-34 (TICS-m)
- (and 8 more...)
|
90 |
All |
18 Years and older (Adult, Senior) |
NCT03190291 |
REBAWF 30917CD 5R21CA198237-02 3UG1CA189824-04S1 |
|
April 2018 |
August 1, 2019 |
February 1, 2020 |
June 16, 2017 |
April 9, 2018 |
|
- Wake Forest School of Medicine
Winston-Salem, North Carolina, United States
|
38 |
NCT03092609 |
Recruiting |
Neuroplasticity in an Extended Amygdala Network as a Target Mechanism for Attention Bias Modification Outcome |
|
- Behavioral: Attention Bias Modification
- Behavioral: Attention Control
|
Interventional |
Not Applicable |
- Northern Michigan University
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Attentional Bias
- State and Trait Anxiety
|
100 |
All |
18 Years to 37 Years (Adult) |
NCT03092609 |
HS13-555 |
|
December 15, 2017 |
September 14, 2020 |
September 14, 2020 |
March 28, 2017 |
March 29, 2018 |
|
- Northern Michigan University
Marquette, Michigan, United States
|
39 |
NCT02579915 |
Recruiting |
Developing a Low-Intensity Primary Care Intervention for Anxiety Disorders (AIM-PC) |
|
- Behavioral: FaceAnxiety
- Behavioral: Symptom Tracking
|
Interventional |
Not Applicable |
- Brown University
- Mclean Hospital
- Memorial Hospital of Rhode Island
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Hamilton Anxiety Rating Scale
- 7-item Generalized Anxiety Disorder Scale
- Patient Health Questionnaire-9
|
42 |
All |
18 Years and older (Adult, Senior) |
NCT02579915 |
1308000908-Phase 2 1R34MH097820-01A1 |
|
September 2015 |
December 2018 |
December 2018 |
October 20, 2015 |
January 18, 2018 |
|
- Family Care Center at Memorial Hospital of Rhode Island
Pawtucket, Rhode Island, United States
|
40 |
NCT00060775 |
Recruiting |
The Psychobiology of Childhood Temperament |
- Mood Disorders
- Anxiety Disorders
- Adolescents
|
|
Observational |
|
- National Institute of Mental Health (NIMH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
1010 |
All |
up to 25 Years (Child, Adult) |
NCT00060775 |
030186 03-M-0186 |
|
May 12, 2003 |
|
|
May 13, 2003 |
April 4, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States - University of Maryland, College Park
College Park, Maryland, United States
|
41 |
NCT02615119 |
Recruiting |
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia Nervosa |
- Anorexia Nervosa
- Major Depressive Disorder
- Generalized Anxiety Disorder
- (and 2 more...)
|
- Drug: Isoproterenol
- Drug: Normal saline
|
Interventional |
Not Applicable |
- Laureate Institute for Brain Research, Inc.
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Change in cardiorespiratory sensation intensity
- Change in anxiety level
- Generalized anxiety disorder severity (Generalized Anxiety Disorder 7 scale)
- (and 3 more...)
|
310 |
All |
18 Years to 55 Years (Adult) |
NCT02615119 |
2017-002 |
|
October 2015 |
October 2020 |
December 2027 |
November 26, 2015 |
May 16, 2017 |
|
- Laureate Institute for Brain Research
Tulsa, Oklahoma, United States
|
42 |
NCT02553161 |
Recruiting |
Mechanism of Antidepressant-Related Dysfunctional Arousal in High-Risk Youth |
- Depression
- Anxiety
- Bipolar Disorder
|
- Drug: Escitalopram
- Behavioral: Cognitive behavioral Psychotherapy
|
Interventional |
Not Applicable |
- University of Cincinnati
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Baseline-endpoint change in prefrontal-amygdala functional connectivity by Scan.
- Week 4- endpoint change in mood by and arousal ratings
|
210 |
All |
12 Years to 17 Years (Child) |
NCT02553161 |
DelBello/Singh AIM R01MH105469 |
|
December 2015 |
December 2019 |
December 2020 |
September 17, 2015 |
February 1, 2018 |
|
- Stanford University
Stanford, California, United States - University of Cincinnati
Cincinnati, Ohio, United States
|
43 |
NCT03175068 |
Recruiting |
Transdiagnostic Brain-Behavior Profiling to Enhance Cognitive Behavioral Therapy Response |
- Major Depressive Disorder
- Social Anxiety Disorder
|
- Behavioral: CBT
- Behavioral: ST
|
Interventional |
Not Applicable |
- University of Illinois at Chicago
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Basic Science
|
- BOLD Effects Measured with Functional Magnetic Resonance Imaging (fMRI)
|
240 |
All |
18 Years to 65 Years (Adult) |
NCT03175068 |
2017-0258 1R01MH112705-01A1 |
|
July 5, 2017 |
June 30, 2022 |
June 30, 2022 |
June 5, 2017 |
October 26, 2017 |
|
- University of Illinois at Chicago
Chicago, Illinois, United States
|
44 |
NCT03239210 |
Recruiting |
Effects of Ondansetron in Obsessive-compulsive and Tic Disorders |
- Obsessive-Compulsive Disorder
- Tic Disorders
- Tourette Syndrome
|
- Drug: Ondansetron
- Drug: Placebo
|
Interventional |
Phase 4 |
- New York University School of Medicine
- National Institutes of Health (NIH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Sensory phenomena severity from baseline to 4 weeks
- Percent BOLD signal change
- Patient-Related Inventory of Side effects
|
60 |
All |
18 Years to 60 Years (Adult) |
NCT03239210 |
17-01608 |
|
June 16, 2017 |
April 2020 |
April 2020 |
August 3, 2017 |
February 26, 2018 |
|
- New York University School of Medicine
New York, New York, United States - The Nathan S. Kline Institute for Psychiatric Research
New York, New York, United States
|
45 |
NCT02950636 |
Recruiting |
Effect of Yoga on Mood and Quality of Life in Patients With Refractory Epilepsy |
|
|
Interventional |
Not Applicable |
- University of Kansas Medical Center
- National Institutes of Health (NIH)
|
Other / NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Change in Neurological Disorders Depression Inventory for Epilepsy (NDDI-E)
- Change in Generalized Anxiety Disorder 7-item (GAD-7) scale
- Change in Quality of Life in Epilepsy-Patient-Weighted (QOLIE-31-p)
- Frequency of seizures
|
20 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02950636 |
STUDY00140045 UL1TR000001 |
|
December 2016 |
June 2017 |
June 2017 |
November 1, 2016 |
December 22, 2016 |
|
- University of Kansas Medical Center
Kansas City, Kansas, United States
|
46 |
NCT02819141 |
Recruiting |
Self-management of Sedative Therapy by Ventilated Patients |
- Critical Illness
- Anxiety
- Respiratory Failure
|
|
Interventional |
Phase 2 Phase 3 |
- Mayo Clinic
- University of Minnesota, MN
- National Heart, Lung, and Blood Institute (NHLBI)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in duration of days receiving mechanical ventilation after study enrollment
- Changes in delirium using the CAM-ICU tool
- Changes in anxiety using the 100mm vertical visual analog scale
- (and 2 more...)
|
228 |
All |
18 Years and older (Adult, Senior) |
NCT02819141 |
16-000417 R01HL030881 |
|
November 2016 |
April 2021 |
November 2021 |
June 30, 2016 |
April 13, 2017 |
|
- School of Medicine, University of Minnesota
Minneapolis, Minnesota, United States - Mayo Clinic in Rochester
Rochester, Minnesota, United States
|
47 |
NCT02505984 |
Recruiting |
Preventing Postpartum Depression With Intranasal Oxytocin |
- Depression, Postpartum
- Anxiety
|
- Drug: Oxytocin
- Drug: Placebo
|
Interventional |
Phase 2 |
- Massachusetts General Hospital
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Treatment effect on mother-infant bonding
- Change in depression symptoms
- Change in anxiety symptoms
- Child development
|
90 |
Female |
18 Years to 50 Years (Adult) |
NCT02505984 |
2015P001100 224421 225686 1R21HD090396-01A1 |
IN-OXT |
October 2015 |
June 2019 |
December 2019 |
July 22, 2015 |
January 30, 2018 |
|
- Massachusetts General Hosptial
Boston, Massachusetts, United States
|
48 |
NCT03096353 |
Recruiting |
Sensory and Opioid Mechanisms of Affective Touch |
|
|
Observational |
|
- National Center for Complementary and Integrative Health (NCCIH)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Crossover
- Time Perspective: Cross-Sectional
|
- Effect of naloxone on touch pleasantness
|
30 |
All |
18 Years to 50 Years (Adult) |
NCT03096353 |
170075 17-AT-0075 |
|
August 1, 2017 |
October 17, 2018 |
October 17, 2019 |
March 30, 2017 |
March 29, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
49 |
NCT03152864 |
Not yet recruiting |
Stabilizing Behavioral Rhythms to Improve Mental Health |
- Depressive Symptoms
- Anxiety Symptoms
- Sleep Symptoms
|
|
Interventional |
Not Applicable |
- HealthRhythms, Inc.
- National Institute of Mental Health (NIMH)
- University of Utah
|
Industry / NIH / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- PROMIS Depression
- PROMIS Anxiety
- PROMIS Sleep
|
128 |
All |
18 Years to 65 Years (Adult) |
NCT03152864 |
1R44MH113520 R44MH113520 |
SRMH |
March 1, 2018 |
March 31, 2019 |
March 31, 2019 |
May 15, 2017 |
August 28, 2017 |
|
|
50 |
NCT03003949 |
Recruiting |
The Menopause Transition: Estrogen Variability, Stress Reactivity and Mood |
- Perimenopausal Disorder
- Stress, Emotional
|
- Drug: Estradiol
- Drug: Placebos
- Drug: Progesterone
- Drug: Placebo Oral Tablet
|
Interventional |
Phase 1 Phase 2 |
- University of North Carolina, Chapel Hill
- National Institute of Mental Health (NIMH)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Change in the Anxiety score from State-Trait Anxiety Inventory
- Change in anhedonia score from Snaith-Hamilton Pleasure Scale
- Changes in adrenocorticotrophic hormone stress response
- (and 3 more...)
|
250 |
Female |
45 Years to 60 Years (Adult) |
NCT03003949 |
16-1731 1R01MH108690-01A1 |
Changes |
January 24, 2017 |
December 2021 |
January 2022 |
December 28, 2016 |
January 17, 2018 |
|
- UNC SHARRP Lab
Chapel Hill, North Carolina, United States - Susan Girdler, PhD, Principal Investigator
Chapel Hill, North Carolina, United States
|