| 1 |
NCT03551847 |
Recruiting |
The Effect of Oral Antibiotics on Synovial Fluid and Differential for the Diagnosis of Infection |
|
- Drug: Antibiotic
- Drug: No antibiotics
|
Interventional
|
Not Applicable |
- Rush University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- A change in synovial fluid white blood cell count with antibiotic treatment
- A change in synovial fluid neutrophil percentage with antibiotic treatment
- A change in culture results with antibiotic treatment
|
170 |
All |
18 Years and older (Adult, Older Adult) |
NCT03551847 |
16071701 |
|
November 1, 2017 |
May 1, 2019 |
December 1, 2020 |
June 11, 2018 |
June 11, 2018 |
|
- Rush University medical Center
Chicago, Illinois, United States
|
|
| 2 |
NCT03658746 |
Not yet recruiting |
Efficacies of Antimicrobial Susceptibility-Guided Versus Empirical Therapy for Rescue Treatment of Helicobacter Pylori Infection |
- Helicobacter Pylori Infection
|
- Drug: two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline)
- Drug: one proton pump inhibitor, colloidal bismuth pectin
- Drug: two antibiotics based on personal medication history(amoxicillin,levofloxacin, furazolidone)
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Eradication rates
- The rates of adverse events happening
- The rates of improving dyspepsia symptoms after helicobacter pylori eradication.
- The rates of good compliance.
|
400 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03658746 |
2018SDU-QILU-G003 |
|
January 1, 2019 |
December 31, 2019 |
April 30, 2020 |
September 5, 2018 |
December 24, 2018 |
|
- Qilu hosipital
Jinan, Shandong, China
|
|
| 3 |
NCT03189043 |
Not yet recruiting |
Controlled Crossover Study of AIONX Antimicrobial Surface for the Prevention of Healthcare-associated Infections |
- Healthcare Associated Infection
|
- Device: Antimicrobial Surface
|
Interventional
|
Phase 2 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Healthcare-Associated Infections
- 30-day Readmission for infection
|
10000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03189043 |
7371 |
|
July 1, 2017 |
October 1, 2017 |
October 1, 2017 |
June 16, 2017 |
June 16, 2017 |
|
|
|
| 4 |
NCT03256825 |
Recruiting |
Rapid Urinary Tract Infection Diagnosis and Real-time Antimicrobial Stewardship Decision Support |
|
- Diagnostic Test: Rapid diagnostics alone
- Other: Real-time antimicrobial stewardship decision support
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- All-cause 30-day mortality
- Adherence to guidelines for empirical therapy
- Total antibiotic consumption in intervention groups and control group compared
- (and 10 more...)
|
550 |
All |
18 Years and older (Adult, Older Adult) |
NCT03256825 |
RUDE/01-2016 |
RUDE |
September 1, 2017 |
March 31, 2019 |
March 31, 2019 |
August 22, 2017 |
May 16, 2018 |
|
- Molde Hospital
Molde, Norway - Ålesund Hospital
Ålesund, Norway
|
|
| 5 |
NCT03633188 |
Recruiting |
Stool Biobanking and Impact of Antimicrobials on the Gut Microbiota in Patients With Bone and Joint Infection |
|
- Biological: Patients treated by antibiotherapy
|
Interventional
|
Not Applicable |
- Hospices Civils de Lyon
- University of Lyon
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- change in the gut microbiota after treatment
- Assessment of the evolution of intensity of Diarrheic Symptoms
- Assessment of the evolution of frequency of Diarrheic Symptoms
- (and 6 more...)
|
35 |
All |
18 Years and older (Adult, Older Adult) |
NCT03633188 |
69HCL17_0652
2017-A02813-50 |
GUMIBONE |
July 19, 2018 |
December 2019 |
December 2019 |
August 16, 2018 |
January 17, 2019 |
|
- Hôpital de la Croix Rousse-Service de chirurgie orthopédique
Lyon, France - Hôpital de la Croix Rousse-Service des Maladies Infectieuses et Tropicales
Lyon, France - Centre Hospitalier Lyon Sud-Service de Chirurgie Orthopédique
Pierre Benite, France - Centre Hospitalier Lyon Sud-Service des maladies infectieuses
Pierre Bénite, France
|
|
| 6 |
NCT03308253 |
Recruiting |
Study for Antibiotic Impregnated Calcium Sulfate Beads as Prophylaxis for Surgical Site Infection |
|
- Device: Stimulan Rapid Cure
- Drug: Vancomycin
- Drug: Tobramycin
- Other: Standard of Care
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Surgical Site Infection
- Wound Complication Rate
- Surgical Graft Infection Rate
- Bacterial Resistance
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03308253 |
Antimicrobial Beads |
|
July 16, 2018 |
June 2019 |
July 2019 |
October 12, 2017 |
July 19, 2018 |
|
- Hamilton General Hospital
Hamilton, Ontario, Canada
|
|
| 7 |
NCT01994538 |
Recruiting |
Seven vs. 14 Days Treatment for Male Urinary Tract Infection |
|
- Other: Longer therapy duration
- Other: Shorter therapy duration
|
Interventional
|
Not Applicable |
- VA Office of Research and Development
|
U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Resolution of UTI symptoms 14 days after completing active antimicrobial therapy
- Recurrent UTI within 28 days of completing active study medication
- Adverse drug event in the 28 days after completing study medication
- Intestinal carriage of antimicrobial-resistant Gram negative bacilli
|
290 |
Male |
18 Years and older (Adult, Older Adult) |
NCT01994538 |
CLIN-008-13S
I01BX007080 |
|
April 24, 2014 |
December 31, 2019 |
December 31, 2019 |
November 25, 2013 |
February 15, 2019 |
|
- Minneapolis VA Health Care System, Minneapolis, MN
Minneapolis, Minnesota, United States - Michael E. DeBakey VA Medical Center, Houston, TX
Houston, Texas, United States
|
|
| 8 |
NCT03636711 |
Not yet recruiting |
Antibiotic Stewardship in Infectious Disease Departement |
|
- Other: antibiotic protocol, according to a syndromic approach
|
Observational
|
|
- Assistance Publique Hopitaux De Marseille
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- List of Antibiotic treatment
- Adverse events
|
2000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03636711 |
2018-24 |
|
September 2018 |
July 2021 |
January 2022 |
August 17, 2018 |
August 17, 2018 |
|
- Assistance Publique Des Hopitaux de Marseille
Marseille, Paca, France
|
|
| 9 |
NCT03612297 |
Not yet recruiting |
Selective Reporting of Antibiotic Susceptibility Test Results in Urinary Tract Infections in the Outpatient Setting |
|
- Diagnostic Test: Selective reporting of Antibiotic Susceptibility Tests
|
Observational
|
|
- Central Hospital, Nancy, France
- University of Lorraine
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Impact of selective reporting of AST for E. coli positive urine cultures in outpatient setting on the prescription of broad-spectrum antibiotics frequently used on UTIs (amoxicillin-clavulanate, third generation cephalosporins and fluoroquinolones)
- Laboratory expenditures (in euros) for the implementation of the intervention
- Satisfaction of GPs and laboratory staffs about selective reporting of AST, assessed by a visual analog scale
|
64000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03612297 |
PREPS-17-0026 |
|
September 1, 2018 |
December 31, 2019 |
April 30, 2020 |
August 2, 2018 |
August 2, 2018 |
|
|
|
| 10 |
NCT03565484 |
Not yet recruiting |
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the Rescue Treatment of Helicobacter Pylori Infection |
- Helicobacter Pylori Infection
|
- Drug: two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline)
- Drug: one proton pump inhibitor(PPI)
- Drug: two antibiotics based on personal medication history(amoxicillin,clarithromycin,furazolidone)
- (and 2 more...)
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Eradication rates in 2 groups
- The rate of improving dyspepsia symptoms after Helicobacter pylori eradication.
|
400 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03565484 |
2017SDU-QILU-G004 |
|
August 1, 2018 |
December 30, 2019 |
April 30, 2020 |
June 21, 2018 |
June 21, 2018 |
|
- Qilu hosipital
Jinan, Shandong, China
|
|
| 11 |
NCT03265834 |
Recruiting |
CABI: Antibiotic Duration for Complicated Intra-ABdominal Infection |
- Complicated Intraabdominal Infections
|
- Other: < 10 days of antibiotics
- Other: 28 days of antibiotics
|
Interventional
|
Phase 2 |
- University of Leeds
- The Leeds Teaching Hospitals NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Number of participants willing to be randomised, the willingness of clinicians to allow participants to be recruited & follow up rates.
- Number of participants who have their antibiotic therapy changed as a consequence of allocation to a certain treatment arm.
- The number of participants who relapse after treatment of complicated intra-abdominal infection.
- (and 9 more...)
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03265834 |
MB16/156 |
CABI |
August 1, 2017 |
March 31, 2018 |
March 31, 2018 |
August 29, 2017 |
August 29, 2017 |
|
- Leeds Teaching Hospitals NHS Trust
Leeds, Yorkshire, United Kingdom
|
|
| 12 |
NCT03151603 |
Recruiting |
Reducing Antibiotic Use for Uncomplicated Urinary Tract Infection in General Practice by Treatment With Uva Ursi (UU)- a Comparative Effectiveness Trial |
|
- Drug: Arctuvan
- Drug: Fosfomycin
- Drug: Placebo to Arctuvan
- Drug: Placebo to Fosfomycin
|
Interventional
|
Phase 4 |
- University Medical Center Goettingen
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- antibiotic courses
- symptom burden
- early relapses
- (and 21 more...)
|
430 |
Female |
18 Years to 75 Years (Adult, Older Adult) |
NCT03151603 |
01579 |
REGATTA |
May 3, 2017 |
May 2019 |
July 2020 |
May 12, 2017 |
June 5, 2017 |
|
- General Practice Aden
Braunschweig, Germany - General Practice Scheffer
Braunschweig, Germany - General Practice Coutelle
Bremen, Germany - (and 31 more...)
|
|
| 13 |
NCT03041207 |
Recruiting |
Decreasing Antibiotic Use in Infants With Suspected Ventilator-associated Infection |
- Ventilator Associated Pneumonia
- Nosocomial Infections in Children
- Microbial Colonization
|
- Behavioral: Development and implementation of an antibiotic guideline
|
Observational
|
|
- Virginia Commonwealth University
- The Gerber Foundation
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Pediatric ICU-free days at 28 days
- Antibiotic days in PICU
- Ventilator-free days at 28 days
- Infection and sepsis episodes
|
586 |
All |
up to 3 Years (Child) |
NCT03041207 |
HM20009140 |
VAIN2 |
March 20, 2017 |
March 1, 2019 |
July 1, 2019 |
February 2, 2017 |
April 18, 2018 |
|
- Banner University Medical Center
Tucson, Arizona, United States - Arkansas Children's Hospital
Little Rock, Arkansas, United States - Children's Hospital of Los Angeles
Los Angeles, California, United States - (and 20 more...)
|
|
| 14 |
NCT01714596 |
Recruiting |
Randomized Trial to Assess PO Versus IV Antibiotics |
|
- Other: PO versus IV antibiotics Route of administration evaluation
|
Interventional
|
Not Applicable |
- Major Extremity Trauma Research Consortium
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Primary objective: investigate the efficacy of oral (PO) antibiotic therapy versus intravenous (IV) antibiotics in the treatment of acute infection after fixation of fractures or joint fusions.
- Patient Adherence
|
264 |
All |
18 Years to 84 Years (Adult, Older Adult) |
NCT01714596 |
METRC POvIV |
POvIV |
December 3, 2013 |
September 30, 2019 |
September 30, 2020 |
October 26, 2012 |
September 5, 2018 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Cedars Sinai Medical Center
Los Angeles, California, United States - Naval Medical Center San Diego
San Diego, California, United States - (and 22 more...)
|
|
| 15 |
NCT03715062 |
Not yet recruiting |
Reducing Antibiotic Prescriptions for Urinary Tract Infection in Long-Term Care Facilities |
|
|
Interventional
|
Not Applicable |
- Research Unit Of General Practice, Copenhagen
- Ministry of the Interior and Health, Denmark
- Velux Fonden
- Herlev Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Prescription of antibiotics for urinary tract infection
- Hospitalization
- Death
- Appropriate prescription of antibiotics for urinary tract infections
|
400 |
All |
65 Years and older (Older Adult) |
NCT03715062 |
111 |
|
December 1, 2018 |
March 31, 2019 |
March 31, 2019 |
October 22, 2018 |
October 22, 2018 |
|
|
|
| 16 |
NCT03221504 |
Recruiting |
7-day Compared With 10-day Antibiotic Treatment for Febrile Urinary Tract Infections in Children |
- Urinary Tract Infections in Children
|
- Other: Longer therapy duration
- Other: Shorter therapy duration
|
Interventional
|
Not Applicable |
- Medical University of Warsaw
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- frequencies of recurrence of UTI
- frequencies of reinfection of UTI
- antibiotic-associated diarrhoea (AAD), compliance
|
221 |
All |
3 Months to 7 Years (Child) |
NCT03221504 |
WUM |
|
January 1, 2018 |
July 31, 2019 |
January 31, 2020 |
July 18, 2017 |
March 20, 2018 |
|
- Children's Hospital for The Medical University of Warsaw
Warsaw, Poland - The Holy Family Specialistic Hospital
Warsaw, Poland
|
|
| 17 |
NCT03571230 |
Not yet recruiting |
Antimicrobial Susceptibility Testing Guided Therapy Versus Empirical Therapy for the First-line Helicobacter Pylori Eradication. |
- Helicobacter Pylori Infection
- Antimicrobial Susceptibility Testing
|
- Drug: two sensitive antibiotics(amoxicillin, clarithromycin, metronidazole, tinidazole, levofloxacin, furazolidone and tetracycline)
- Drug: two antibiotics based on personal medication history(amoxicillin,clarithromycin,furazolidone)
- Drug: one proton pump inhibitor(PPI)
- (and 2 more...)
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Eradication rates in 2 groups
- The rate of improving dyspepsia symptoms after Helicobacter pylori eradication.
- The rate of adverse events happening
- (and 2 more...)
|
400 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03571230 |
2017SDU-QILU-G003 |
|
July 1, 2018 |
December 30, 2019 |
January 30, 2020 |
June 27, 2018 |
June 27, 2018 |
|
- Xiuli Zuo
Jinan, Shandong, China
|
|
| 18 |
NCT03191071 |
Recruiting |
An Algorithm to Decide on Antibiotic Prescription in Lower Respiratory Tract Infection in Primary Care |
- Lower Resp Tract Infection
|
- Diagnostic Test: UltraPro
- Diagnostic Test: Procalcitonin
- Diagnostic Test: Blood sampling
- Diagnostic Test: Naso-pharyngeal swab and sputum culture
|
Interventional
|
Not Applicable |
- Centre Hospitalier Universitaire Vaudois
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Proportion of patients prescribed an antibiotic in each arm
- Duration of the episode
- Clinical failure
- (and 9 more...)
|
630 |
All |
18 Years and older (Adult, Older Adult) |
NCT03191071 |
SNF 407240_167133/1 |
UltraPro |
September 1, 2018 |
February 1, 2020 |
April 30, 2020 |
June 19, 2017 |
January 23, 2019 |
|
- Centre Hospitalier Universitaire Vaudois
Lausanne, Vaud, Switzerland
|
|
| 19 |
NCT03120975 |
Recruiting |
Computerized Antibiotic Stewardship Study |
|
- Other: Computerized decision support and audit & feedback
- Other: Audit & Feedback
- Other: Standard antibiotic stewardship
|
Interventional
|
Not Applicable |
- Benedikt Huttner
- Swiss National Science Foundation
- University of Geneva, Switzerland
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Days of therapy (DOT)/admission
- Days of therapy(DOT)/100 patient days
- Defined daily doses (DDD)/100 patient days (PD) and per admission
- (and 19 more...)
|
5000 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT03120975 |
2017-00454
407240_167079 |
COMPASS |
September 3, 2018 |
December 31, 2019 |
March 31, 2020 |
April 19, 2017 |
February 5, 2019 |
|
- Geneva University Hospitals
Geneva, GE, Switzerland - Ente Ospedaliera Cantonale - Ospedale San Giovanni
Bellinzona, TI, Switzerland - Ente Ospedaliera Cantonale - Ospedale Civico
Lugano, TI, Switzerland
|
|
| 20 |
NCT03408457 |
Recruiting |
Influence of Perioperative Fluid Balance on Serum Concentrations of Antibiotics and Surgical Site Infections |
- Antibiotic
- Anti-Bacterial Agents
- Surgical Wound Infection
|
- Procedure: Blood sampling after antibiotic administration
|
Observational
|
|
- Johannes Gutenberg University Mainz
|
Other |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Serum concentration of antibiotic
- Surgical wound infection
|
130 |
All |
18 Years and older (Adult, Older Adult) |
NCT03408457 |
837.402.17 (11236)
U1111-1207-8265 |
|
March 14, 2018 |
January 31, 2019 |
January 31, 2019 |
January 24, 2018 |
March 16, 2018 |
|
- Medical Center of the Johannes Gutenberg-University Mainz
Mainz, Rheinland-Pfalz, Germany
|
|
| 21 |
NCT03250104 |
Recruiting |
Antibiotic Stewardship and Infection Control in Patients at High Risk of Developing Infection by Clostridium Difficile, Vancomycin-Resistant Enterococci or Multi-Resistant Gram-Negatives |
- Clostridium Difficile Infection
- VRE Infection
- Nosocomial Infection
- MRGN Bacteria
|
- Other: Infection Control
- Other: Antibiotic Stewardship
|
Observational
|
|
- University Hospital of Cologne
- Charite University, Berlin, Germany
- University Hospital Freiburg
- (and 3 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- CDI incidence
- Effectiveness of IC bundle through incidence of CDI or BSI by VRE and MRGN
- PPI usage
- (and 4 more...)
|
80000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03250104 |
TTU HAARBI 8.810 |
ABSOLUTE |
November 2016 |
December 2018 |
December 2020 |
August 15, 2017 |
October 16, 2018 |
|
- University Hospital of Cologne
Cologne, NRW, Germany
|
|
| 22 |
NCT03644966 |
Recruiting |
Probiotics and Multi-Drug Resistant Urinary Tract Infection |
- Urinary Tract Infections
- Recurrent UTI
- Antibiotic Resistant Infection
|
- Dietary Supplement: Bifidobacterium infantis
- Other: Placebo
- Drug: Antibiotics
|
Interventional
|
Not Applicable |
- Ochsner Health System
- Procter and Gamble
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Resistance Pattern
- Bacterial isolate genomic characteristics
- UTI reduction
- (and 4 more...)
|
100 |
Female |
18 Years to 90 Years (Adult, Older Adult) |
NCT03644966 |
2017564 |
|
July 5, 2018 |
May 29, 2019 |
November 29, 2019 |
August 23, 2018 |
August 23, 2018 |
|
- Ochsner Health System
Jefferson, Louisiana, United States
|
|
| 23 |
NCT02424461 |
Recruiting |
Antibiotic Treatment for 7 Days Versus 14 Days in Patients With Acute Male Urinary Tract Infection |
- Acute Male Urinary Tract Infection
|
- Drug: Ceftriaxone
- Drug: Ofloxacine
- Drug: Placebo of ofloxacine
|
Interventional
|
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Success defined by resolution of fever
- Intestinal carriage of antimicrobial-resistant Gram-negative bacilli
- Incidence and severity of adverse drug events
- Recurrent UTI
|
400 |
Male |
18 Years and older (Adult, Older Adult) |
NCT02424461 |
P120116
AOM12268 |
PROSTASHORT |
February 2015 |
December 2019 |
December 2020 |
April 23, 2015 |
February 19, 2019 |
|
- Saint Louis hospital
Paris, France
|
|
| 24 |
NCT02692651 |
Recruiting |
A Comparison of Fidaxomicin and Vancomycin in Patients With CDI Receiving Antibiotics for Concurrent Infections |
- Clostridium Difficile Infection (CDI)
|
- Drug: Fidaxomicin
- Drug: Vancomycin
|
Interventional
|
Phase 4 |
- University of Michigan
- Merck Sharp & Dohme Corp.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical Cure: Resolution of diarrhea
- Recurrence of CDI
|
250 |
All |
18 Years and older (Adult, Older Adult) |
NCT02692651 |
Merck Fidaxo |
|
May 1, 2017 |
January 2020 |
April 2020 |
February 26, 2016 |
May 3, 2018 |
|
- University of Michigan
Ann Arbor, Michigan, United States
|
|
| 25 |
NCT03311113 |
Not yet recruiting |
Adherence to Oral Antibiotics In Patients With Osteoarticular Infections |
- Bone and Joint Infection
- Adherence, Medication
|
- Other: Drug adherence questionnaire
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of patients with high, moderate and poor adherence
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT03311113 |
69HCL17_0467 |
OBSAIO |
November 2017 |
November 2018 |
November 2018 |
October 16, 2017 |
October 16, 2017 |
|
- Centre de référence des infections ostéo-articulaires de Lyon
Lyon, France
|
|
| 26 |
NCT03341273 |
Recruiting |
A Randomized Double-Blinded, Placebo-Controlled Trial of Antibiotic Therapy in Patients With Lower Respiratory Tract Infection (LRTI) and a Procalcitonin Level |
- Lower Respiratory Tract Infection
|
- Drug: Azithromycin
- Other: Placebo
- Device: VIDAS B.R.A.H.M.S Procalcitonin Test (PCT)
|
Interventional
|
Not Applicable |
- National Institute of Allergy and Infectious Diseases (NIAID)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Diagnostic
|
- Clinical improvement: improvement in > / = 2 symptoms or 1 symptom and > / = 1 vital sign abnormality; no deterioration in symptom; no fever; no ambulatory medical facility visit/hospitalization for persistent/worsening LTRI, in Azithromycin group
- Clinical improvement: improvement in > / = 2 symptoms or 1 symptom and > / = 1 vital sign abnormality; no deterioration in symptom; no fever; no ambulatory medical facility visit/hospitalization for persistent/worsening LTRI, in placebo group
- Clinical improvement: improvement in > / = 2 symptoms or 1 symptom (as applicable); no deterioration in symptom; no fever; no ambulatory medical facility visit/hospitalization for persistent/worsening LTRI, in Azithromycin group
- (and 22 more...)
|
420 |
All |
18 Years to 99 Years (Adult, Older Adult) |
NCT03341273 |
15-0020
HHSN272201300015I |
|
December 8, 2017 |
December 29, 2019 |
February 4, 2020 |
November 14, 2017 |
September 17, 2018 |
|
- Emory Vaccine Center - The Hope Clinic
Atlanta, Georgia, United States - Atlanta VA Medical Center - Infectious Diseases Clinic
Decatur, Georgia, United States - Durham VA Medical Center
Durham, North Carolina, United States - (and 2 more...)
|
|
| 27 |
NCT02255305 |
Recruiting |
FMT Versus Antimicrobials for Initial Treatment of Recurrent CDI |
- Clostridium Difficile Infection
|
- Biological: FMT
- Drug: Antimicrobials
|
Interventional
|
Phase 2 |
- NorthShore University HealthSystem
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical Resolution of Diarrhea
- Time to Clinical Resolution of Symptoms
- Hospital Length of Stay
- Readmission and Mortality
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT02255305 |
EH 14-331 |
|
January 2015 |
September 2019 |
December 2019 |
October 2, 2014 |
April 18, 2018 |
|
- NorthShore University HealthSystem
Evanston, Illinois, United States
|
|
| 28 |
NCT03595852 |
Recruiting |
Antibiotic Prophylaxis in Clean Surgery. Impact on Surgical Site Infection |
|
- Drug: Cefazolin
- Drug: Placebos
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Health Services Research
|
- Surgical site infection
- mortality
- morbidity
|
138 |
All |
Child, Adult, Older Adult |
NCT03595852 |
1234 |
|
March 1, 2018 |
September 2018 |
March 2019 |
July 23, 2018 |
July 23, 2018 |
|
- Kigali University Teaching Hospital (Chuk)
Kigali, Rwanda
|
|
| 29 |
NCT01871753 |
Recruiting |
The Bacteriuria in Renal Transplantation (BiRT) Study: A Trial Comparing Antibiotics Versus no Treatment in the Prevention of Symptomatic Urinary Tract Infection in Kidney Transplant Recipients With Asymptomatic Bacteriuria |
- Asymptomatic Bacteriuria
- Bacteriuria
- Urinary Tract Infections
- Kidney Transplantation
|
- Other: Anti-Infective Agents
|
Interventional
|
Phase 4 |
- Erasme University Hospital
- University Hospital, Lille
- Universitair Ziekenhuis Brussel
- (and 7 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- cumulative incidence of a first episode of symptomatic urinary tract infection
- incidence of a first episode of pyelonephritis
- clearance of asymptomatic bacteriuria
- (and 10 more...)
|
198 |
All |
18 Years and older (Adult, Older Adult) |
NCT01871753 |
BiRT study
2012-003857-26 |
BiRT |
April 2014 |
June 2019 |
|
June 7, 2013 |
January 31, 2018 |
|
- Universitair Ziekenhuis Antwerpen
Antwerpen, Belgium - Centre Hospitalier Epicura
Baudour, Belgium - Centre Hospitalier Universitaire Brugmann
Brussels, Belgium - (and 12 more...)
|
|
| 30 |
NCT02547025 |
Recruiting |
Personalized Treatment for Refractory H Pylori Infection |
- Helicobacter Pylori Infection
|
- Drug: rabeprazole+3 antibiotics
- Drug: rabeprazole+bismuth+2 antibiotics
- Drug: rabeprazole+amox+tetr+levo
|
Interventional
|
Not Applicable |
- Kaohsiung Veterans General Hospital.
- Kaohsiung Medical University Chung-Ho Memorial Hospital
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of Participants in Which H. Pylori Was Eradicated
|
150 |
All |
20 Years to 90 Years (Adult, Older Adult) |
NCT02547025 |
VGHKS13-CT12-17 |
|
December 2013 |
December 2019 |
December 2019 |
September 11, 2015 |
October 12, 2018 |
|
- Kaohsiung Veterans General Hospital
Kaohsiung, Taiwan
|
|
| 31 |
NCT03825874 |
Recruiting
New |
Research of the Consequences on the Digestive Tract Following the Proposed Treatments for a Urinary Infection in Children |
- Urinary Tract Infections
- Urinary Tract Infections in Children
|
- Other: Amikacin
- Other: usual antibiotic treatment
|
Observational
|
|
- Centre Hospitalier Intercommunal Creteil
|
Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Presence of E-BLSE in stools
- Type of E-BLSE strain in stools
- Rate of enzymatic resistance of E-BLSE strain in stools
- (and 3 more...)
|
200 |
All |
3 Months to 3 Years (Child) |
NCT03825874 |
MIKA
2017-A02372-51 |
MIKA |
January 18, 2019 |
September 1, 2020 |
December 1, 2020 |
January 31, 2019 |
January 31, 2019 |
|
- Antoine Beclère Hospital
Clamart, Ile-de France, France - Jean Verdier Hospital
Bondy, Ile-de-France, France - André Mignot Hospital
Le Chesnay, Ile-de-France, France - (and 40 more...)
|
|
| 32 |
NCT01595529 |
Recruiting |
The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children" |
|
- Drug: Cefixime
- Drug: Cephalexin
- Other: Placebo
- Drug: Trimethoprim/Sulfamethoxazole
|
Interventional
|
Phase 2 |
- National Institute of Allergy and Infectious Diseases (NIAID)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Comparison of efficacy based on symptomatic Urinary Tract Infection (UTI) between short-course and standard-course of antibiotics.
- Comparison of number of subjects that have a recurrent infection (includes a relapse UTI or a reinfection) following short-course versus standard-course of antibiotics.
- Comparison of the number of subjects that become colonized with antimicrobial resistant Escherichia coli (E. coli) and Klebsiella pneumoniae (K. pneumoniae) in the gastrointestinal tract following short-course versus standard course of antibiotics.
- (and 3 more...)
|
746 |
All |
2 Months to 10 Years (Child) |
NCT01595529 |
09-0103 |
|
May 18, 2012 |
June 30, 2019 |
December 31, 2019 |
May 10, 2012 |
December 24, 2018 |
|
- Children's Hospital of Pittsburgh of UPMC - General Academic Pediatric
Pittsburgh, Pennsylvania, United States
|
|
| 33 |
NCT02901717 |
Recruiting |
Mino-Lok Therapy (MLT) for the Treatment of CRBSI/CLABSI |
- Catheter-related Infections
|
- Drug: Mino-Lok
- Drug: Antibiotic lock
|
Interventional
|
Phase 3 |
- Leonard-Meron Biosciences, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Proportion of subjects deemed successfully treated at the end of the study period
- Proportion of subjects with a response of Clinical Cure at End of Treatment.
- Proportion of subjects in the MITT and CE Populations with a response of microbiological eradication.
- (and 2 more...)
|
700 |
All |
12 Years and older (Child, Adult, Older Adult) |
NCT02901717 |
MDA-2013-0039 |
|
February 13, 2018 |
June 2019 |
September 2019 |
September 15, 2016 |
July 10, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States - Georgetown University Hospital
Washington, District of Columbia, United States - University of Chicago
Chicago, Illinois, United States - (and 9 more...)
|
|
| 34 |
NCT03099863 |
Recruiting |
Cytoscopic Antibiotic Irrigant to Reduce Postoperative Urinary Tract Infection |
|
- Drug: Cystoscopic Fluid containing Neosporin G. U. Irrigant
- Procedure: Cystoscopy
- Drug: Cystoscopic Fluid/Placebo
|
Interventional
|
Phase 4 |
- MetroHealth Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Prevention
|
|
242 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03099863 |
IRB15-00769 |
|
April 2016 |
June 2019 |
June 2019 |
April 4, 2017 |
November 28, 2018 |
|
- MetroHealth Medical Center
Cleveland, Ohio, United States
|
|
| 35 |
NCT03363451 |
Recruiting |
A Study on Diagnosis and Treatment of End Stage Liver Disease Complicated With Infection (SESLDIR Study) |
- End Stage Liver Disease
- Infection
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Complete response rate to empirical antibiotic treatment
- Non-liver transplant survival
- Hospitalization time
|
2000 |
All |
Child, Adult, Older Adult |
NCT03363451 |
SESLDIR study |
|
February 1, 2018 |
December 30, 2018 |
December 31, 2018 |
December 6, 2017 |
September 14, 2018 |
|
- Department of Infectious Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China
|
|
| 36 |
NCT03643497 |
Recruiting |
Population Pharmacokinetics of Meropenem and Linezolid in Children With Severe Infectious Diseases |
|
- Drug: anti-infective drugs
|
Observational
|
|
- Beijing Children's Hospital
- Shandong University
- Robert Debré Hospital
- Rennes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- maximum concentration (Cmax)
- time to achieve maximum concentration (Tmax)
- absorption rate constant (ka)
- (and 2 more...)
|
800 |
All |
up to 18 Years (Child, Adult) |
NCT03643497 |
BCH_PPK004 |
|
July 1, 2018 |
September 30, 2021 |
December 31, 2021 |
August 22, 2018 |
August 23, 2018 |
|
- Beijing Children's Hospital of Capital Medical University
Beijing, China
|
|
| 37 |
NCT02503904 |
Not yet recruiting |
Tumescent Antibiotic Delivery for Prevention of Surgical Site Infection |
- Surgical Site Infections
- Venous Thromboembolism
|
- Procedure: Concomitant Tumescent Antibiotic Delivery & IV Delivery
- Device: Subcutaneous Tumescent Infiltration
- Drug: cecefazolin and metronidazole (in a dilute solution of tumescent lidocaine, epinephrin and sodium bicarbonate in 0.9% physiologic saline)
|
Interventional
|
Phase 2
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of surgical site infections
- Number of post-operative venous thromboembolism
- Amount of postoperative narcotic required
- (and 2 more...)
|
400 |
All |
18 Years and older (Adult, Older Adult) |
NCT02503904 |
TAD4SSI |
|
October 2015 |
June 2019 |
December 2019 |
July 21, 2015 |
July 21, 2015 |
|
|
|
| 38 |
NCT03583476 |
Recruiting |
The Impact of Antibiotics MIC Value on the Efficacy of Treatment Regimens for Helicobacter Pylori Infection. |
- Helicobacter Pylori Infection
|
- Drug: Proton pump inhibitor,clarithromycin,amoxicillin or metronidazole
|
Observational
|
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Relationship between eradication rate (%) of therapy regimen and influencing factors (eg. sex, age, diagnosis, MIC).
|
1821 |
All |
20 Years and older (Adult, Older Adult) |
NCT03583476 |
201804076RIND |
|
April 1, 2018 |
December 31, 2018 |
December 31, 2018 |
July 11, 2018 |
July 11, 2018 |
|
- Tzu-Chi Lai
Taipei city, No.33, Linsen S. Rd., Zhongzheng Dist, Taiwan
|
|
| 39 |
NCT03765528 |
Not yet recruiting |
Impact of Prescription Quality, Infection Control and Antimicrobial Stewardship on Gut Microbiota Domination by Healthcare-Associated Pathogens |
- Patients at High Risk of Antibacterial Treatment Upon Admission
|
|
Observational
|
|
- University Hospital of Cologne
- University Hospital of North Norway
- Karolinska Institutet
- (and 7 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Impact of inappropriate antibacterial prescription on intestinal microbiota domination by healthcare associated pathogens
- Time-point of Intestinal Colonization
- Time-point of Intestinal Domination
- (and 4 more...)
|
1500 |
All |
18 Years and older (Adult, Older Adult) |
NCT03765528 |
PILGRIM |
PILGRIM |
December 1, 2018 |
December 31, 2020 |
March 31, 2021 |
December 5, 2018 |
December 5, 2018 |
|
- University Hospital of Cologne
Cologne, NRW, Germany
|
|
| 40 |
NCT03247920 |
Recruiting |
Reduction of Intravenous Antibiotics In Neonates |
- Neonatal Infection
- Neonatal SEPSIS
|
- Drug: Amoxicillin Clavulanate
- Drug: Antibiotics
|
Interventional
|
Phase 4 |
- Franciscus Gasthuis
- Erasmus Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Bacterial re-infection within 28 days after cessation of antibiotic treatment (within 35 days after initial presentation)
- Duration of hospitalization
- Percentage of re-admission
- (and 4 more...)
|
550 |
All |
up to 28 Days (Child) |
NCT03247920 |
RAIN |
RAIN |
November 4, 2017 |
January 1, 2020 |
January 1, 2021 |
August 14, 2017 |
January 30, 2019 |
|
- IJsselland Ziekenhuis
Capelle Aan Den IJssel, Netherlands - Sint Antonius Ziekenhuis
Nieuwegein, Netherlands - Erasmus MC-Sophia Children's Hospital
Rotterdam, Netherlands - (and 4 more...)
|
|
| 41 |
NCT03411538 |
Recruiting |
Mortality Related to AMR in Patients With Hospital-acquired Infection |
- Hospital-acquired Infections
|
- Other: Collect data on clinical history
|
Observational
|
|
- University of Oxford
- Sanpasitthiprasong Hospital
- Mahidol Oxford Tropical Medicine Research Unit
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
4000 |
All |
Child, Adult, Older Adult |
NCT03411538 |
MICRO1707 |
HAMR |
March 1, 2018 |
February 28, 2020 |
February 28, 2020 |
January 26, 2018 |
July 6, 2018 |
|
- Sunpasitthiprasong Hospital
Ubon Ratchathani, Thailand
|
|
| 42 |
NCT03265028 |
Not yet recruiting |
TRACE E-learning Implementation in Belgium |
- Respiratory Tract Infections
|
- Behavioral: TRACE e-learning
|
Interventional
|
Not Applicable |
- Universiteit Antwerpen
- Belgian Antibiotic Policy Coordination Committee (BAPCOC)
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Antibiotic use (short term)
- Antibiotic use (intermediate term)
- Antibiotic use (long term)
|
15000 |
All |
Child, Adult, Older Adult |
NCT03265028 |
TRACE Implementation |
|
September 2017 |
January 2019 |
December 2019 |
August 29, 2017 |
September 20, 2017 |
|
|
|
| 43 |
NCT02900820 |
Recruiting |
Safety of Discontinuing Patient Antibiotic Treatment |
- Infectious Diseases
- Respiratory Tract Infections
|
- Other: Discontinuing antibiotic therapy
- Other: Continuing antibiotic therapy
|
Interventional
|
Not Applicable |
- Spanish Society of Family and Community Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Duration of severe symptoms
- Adverse effects of the medication
- Antibiotic consumption
- (and 3 more...)
|
430 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02900820 |
16/101 |
STOP-AB |
January 2017 |
September 2019 |
December 2019 |
September 14, 2016 |
November 1, 2018 |
|
- Coll d'en Rabassa Primary Health Center
Palma de Mallorca, Balearic Islands, Spain - Manso - Via Roma Primary Care Center
Barcelona, Catalonia, Spain - La Marina Primary Care Center
Barcelona, Catalonia, Spain - (and 2 more...)
|
|
| 44 |
NCT03697096 |
Recruiting |
The INSPIRE-ASP UTI Trial |
- Urinary Tract Infection (UTI)
|
- Other: Routine Care
- Other: INSPIRE CPOE Smart Prompt
|
Interventional
|
Not Applicable |
- Harvard Pilgrim Health Care
- Hospital Corporation of America Healthcare (HCA)
- University of California, Irvine
- (and 3 more...)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Proportion of Days with Empiric Extended-Spectrum (ES) Antibacterial Treatment for UTI
- Proportion of Days with Empiric Vancomycin Treatment for UTI
- Proportion of Days with Empiric Antipseudomonal Treatment for UTI
|
59 |
All |
18 Years and older (Adult, Older Adult) |
NCT03697096 |
PH000619B_UTI |
|
October 1, 2018 |
June 30, 2022 |
June 30, 2024 |
October 5, 2018 |
October 29, 2018 |
|
- Riverside Community Hospital
Riverside, California, United States - Regional Medical Center of San Jose
San Jose, California, United States - Los Robles Regional Medical Center
Thousand Oaks, California, United States - (and 56 more...)
|
|
| 45 |
NCT01760863 |
Recruiting |
Oral Antibiotics After 2-Stage Revision for Infected Total Hip Arthroplasty and Total Knee Arthroplasty |
- Prosthesis-Related Infections
|
|
Interventional
|
Not Applicable |
- Rush University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
|
200 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT01760863 |
11040802 |
|
July 2011 |
December 2018 |
December 2020 |
January 4, 2013 |
June 8, 2018 |
|
- Rush University Medical Center
Chicago, Illinois, United States - Central DuPage Hospital
Winfield, Illinois, United States - Rothman Institute
Philadelphia, Pennsylvania, United States - Vanderbilt
Nashville, Tennessee, United States
|
|
| 46 |
NCT03113344 |
Recruiting |
Population Pharmacokinetics of Anti-infective Drugs in Children With Infectious Diseases |
|
- Drug: cephalosporins,penicillins,macrolides,carbapenems and antiviral drugs
|
Observational
|
|
- Beijing Children's Hospital
- Shandong University
- Robert Debré Hospital
- Rennes University Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- maximum concentration (Cmax)
- time to achieve maximum concentration (Tmax)
- absorption rate constant (ka)
- (and 2 more...)
|
800 |
All |
up to 18 Years (Child, Adult) |
NCT03113344 |
BCH_PPK002
Yu-Jie Qi
Wei Zhao
Hui Qi
Fei Jin
Evelyne Jacqz-Aigrain
Stephanie Leroux |
|
June 21, 2017 |
October 1, 2025 |
December 31, 2025 |
April 13, 2017 |
December 19, 2017 |
|
- Beijing Children's Hospital of Capital Medical University
Beijing, China
|
|
| 47 |
NCT03299387 |
Recruiting |
INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI |
|
- Drug: Nitrofurantoin
- Drug: Gentamicin
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in microbiologic effect of a chronic acute Urinary Tract Infection
- Change in symptomatic relief of a chronic acute Urinary Tract Infection
- To establish the clinical FTE needs for providing urgent intravesical treatments
|
40 |
Female |
18 Years and older (Adult, Older Adult) |
NCT03299387 |
11-002887 |
INSTANT |
June 28, 2017 |
July 1, 2019 |
July 14, 2019 |
October 3, 2017 |
October 3, 2017 |
|
- Mayo Clinic
Rochester, Minnesota, United States
|
|
| 48 |
NCT03540706 |
Recruiting |
Impact of the Use of mCRP on the Prescription of Antibiotics in General Practitioners |
- Respiratory Infection
- Respiratory Infections in Children
|
- Diagnostic Test: Care with C-reactive protein assay in micro method
|
Interventional
|
Not Applicable |
- Centre Hospitalier Intercommunal Creteil
- ACTIV
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Rates of antibiotic therapy prescribed
- Rates of antibiotic therapy prescribed in patients aged from 3 to 17 years old
- Rates of antibiotic therapy prescribed in patients aged from 18 to 64 years old
- (and 8 more...)
|
3340 |
All |
3 Years and older (Child, Adult, Older Adult) |
NCT03540706 |
VIP
2018-A00242-53
AOR17072 |
VIP |
May 1, 2018 |
August 31, 2020 |
December 2020 |
May 30, 2018 |
February 1, 2019 |
|
- 22 rue de Silly
Boulogne, France - 25 avenue des frères Lumière
Cormeilles-en-Parisis, France - 8 Rue Saint-Exupéry
Meudon La Forêt, France - (and 9 more...)
|
|
| 49 |
NCT02395614 |
Recruiting |
Surgical Site Infection With 0.05% Chlorhexidine (CHG) Compared to Triple Antibiotic Irrigation |
|
- Drug: Chlorhexidine irrigation
- Drug: triple antibiotic irrigation
|
Interventional
|
Not Applicable |
- Vanderbilt University Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- frequency of surgical site infection as defined by CDC
|
60 |
Female |
18 Years to 81 Years (Adult, Older Adult) |
NCT02395614 |
140231 |
|
December 2015 |
January 2019 |
January 2019 |
March 23, 2015 |
June 15, 2018 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
|
| 50 |
NCT01373099 |
Recruiting |
Study of Antibiotic Spacer Design to Treat Infection After Hip Replacement |
- Osteoarthritis
- Hip Infection
- Prosthetic Joint Infection
- (and 2 more...)
|
- Procedure: Implantation of a static, non-articulating cement spacer.
- Procedure: Implantation of an articulating spacer.
|
Interventional
|
Not Applicable |
- Rush University Medical Center
- Thomas Jefferson University
- Central DuPage Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Harris Hip Score
- Operative time
- Hip dislocation rates
|
80 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT01373099 |
SPACERHIP |
SPACERHIP |
August 2011 |
August 2020 |
August 2020 |
June 14, 2011 |
August 28, 2018 |
|
- Rush University Medical Center
Chicago, Illinois, United States
|
|
| 51 |
NCT02988089 |
Recruiting |
Antimicrobial Susceptibility Testing Guided Antibiotic Selection Strategies in Salvage Helicobacter Pylori Treatment |
- Helicobacter Pylori Infection
- Antimicrobial Susceptibility Testing
|
- Drug: Clarithromycin susceptibility dependant strategy
- Drug: 2 susceptible antibiotics (amoxicillin, clarithromycin, metronidazole, tinidazole,levofloxacin, furazolidone and tetracycline )
- Drug: proton pump inhibitor (PPI) and Colloidal Bismuth Pectin
- (and 3 more...)
|
Interventional
|
Phase 4 |
- Shandong University
- Shandong Provincial Hospital
- General Hospital of Jinan Military Region
- (and 2 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Eradication rates in 2 groups
- the rate of improving dyspepsia symptoms after H. pylori eradication
- the rate of adverse events happening
- (and 2 more...)
|
480 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02988089 |
2016SDU-QILU-23 |
|
April 20, 2017 |
September 2017 |
September 2017 |
December 9, 2016 |
April 25, 2017 |
|
- Department of Gastroenterology, Qilu Hospital, Shandong University
Ji'nan, Shandong, China
|
|
| 52 |
NCT03508921 |
Recruiting |
Comparison of Methods for Prevention of Urinary Tract Infection Following Botox Injection |
- Overactive Bladder
- Urinary Tract Infections
|
- Procedure: Periprocedural Antibiotics
- Drug: Extended Antibiotics
- Procedure: Injection of OnabotulinumtoxinA (BTX-A)
|
Interventional
|
Phase 4 |
- Vanderbilt University Medical Center
- The Allergan Foundation
- Society of Urodynamics, Female Pelvic Medicine and Urogenital Reconstruction
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Post procedural- urinary tract infection
- Urinary retention
- Recurrent urinary tract infection
|
68 |
All |
18 Years and older (Adult, Older Adult) |
NCT03508921 |
00011112222 |
|
July 1, 2018 |
June 1, 2019 |
September 1, 2019 |
April 26, 2018 |
August 10, 2018 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
|
| 53 |
NCT03402945 |
Recruiting |
Prevention of Infections in Cardiac Surgery (PICS) Prevena Study |
|
- Device: Prevena
- Drug: Cefazolin
- Drug: Vancomycin
- Other: standard wound dressing
|
Interventional
|
Phase 4 |
- Population Health Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- Adherence to the wound management system
- Adherence to the antibiotic regimen
- Loss of follow-up
- (and 7 more...)
|
4000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03402945 |
PICS-PREVENA V1_20171106 |
PICS-Prevena |
March 5, 2018 |
April 2020 |
July 2020 |
January 18, 2018 |
September 5, 2018 |
|
- Hamilton General Hospital
Hamilton, Ontario, Canada - London Health Sciences Centre & Lawson Health Research Institute
London, Ontario, Canada
|
|
| 54 |
NCT03752424 |
Recruiting |
Topical Silver Nanoparticles for Microbial Activity |
- Foot Infection Fungal
- Infection, Bacterial
|
- Drug: Silver nanoparticles
- Drug: Topical approved anti-microbial gel
|
Interventional
|
Phase 1 |
- Ahmed A. H. Abdellatif
- Al-Azhar University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- The antimicrobial activity of silver nanoparticles in the two groups of control and an infected patient will be determined. Each group will be of 6 volunteers, each one will be controlled for the CTCAE.
- Stable topical anti-microbial silver nanoparticles
|
30 |
All |
20 Years to 60 Years (Adult) |
NCT03752424 |
AlAzharSilver |
|
January 13, 2019 |
January 12, 2020 |
January 11, 2021 |
November 26, 2018 |
November 26, 2018 |
|
- Buraidah Clinic
Buraidah, Al Qassim, Saudi Arabia
|
|
| 55 |
NCT01373112 |
Recruiting |
Articulating Versus Static Antibiotic Loaded Spacers for the Treatment of Prosthetic Knee Infection |
- Osteoarthritis
- Knee Infection
- Prosthetic Joint Infection
- (and 2 more...)
|
- Procedure: Static Spacer
- Procedure: Articulating Spacer
|
Interventional
|
Not Applicable |
- Rush University Medical Center
- Central DuPage Hospital
- Joint Implant Surgeons, Inc.
- Thomas Jefferson University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Range of motion
- Knee Society Score
- Operative time
|
140 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT01373112 |
SPACERKNEE |
|
December 2011 |
August 2020 |
August 2020 |
June 14, 2011 |
August 28, 2018 |
|
- Rush University Medical Center
Chicago, Illinois, United States
|
|
| 56 |
NCT01792804 |
Recruiting |
Staphylococcus Aureus Bacteremia Antibiotic Treatment Options |
- Staphylococcus Aureus Infection
|
- Drug: Trimethoprim-Sulfamethoxazole
- Drug: Clindamycin
- Drug: Linezolid
- (and 5 more...)
|
Interventional
|
Phase 3 |
- Heinrich-Heine University, Duesseldorf
- German Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- SAB-related complications
- Length of hospital stay
- Survival
- Complications of intravenous therapy
|
215 |
All |
18 Years and older (Adult, Older Adult) |
NCT01792804 |
Uni-Koeln-1400
2013-000577-77 |
SABATO |
December 2013 |
October 2019 |
October 2019 |
February 15, 2013 |
October 22, 2018 |
|
- Annecy
Annecy, France - Chambéry
Chambéry, France - Grenoble
Grenoble, France - (and 39 more...)
|
|
| 57 |
NCT03784807 |
Recruiting |
New Strategies for Biofilm Related Infections |
- Prosthetic Joint Infection
|
- Diagnostic Test: synovial calprotectin, confocal laser microscopy
|
Observational
|
|
- Istituto Ortopedico Galeazzi
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Assessment of analytical performance of calprotectin and CLSM for diagnosis of prosthetic joint infections
- Improvement in antibiotic therapy applying data obtained from antibiotic susceptibility testing on biofilm
|
99 |
All |
18 Years and older (Adult, Older Adult) |
NCT03784807 |
Diafilm |
Diafilm |
November 2, 2018 |
September 30, 2020 |
November 30, 2020 |
December 24, 2018 |
December 24, 2018 |
|
- IRCCS Istituto Ortopedico Galeazzi
Milano, MI, Italy
|
|
| 58 |
NCT03483363 |
Recruiting |
Topical Antibiotic Irrigation (Bacitracin) in Prophylaxis of Midfacial Fracture Surgical Wounds |
|
- Drug: topical irrigation with the antibiotic bacitracin
- Drug: topical irrigation with sterile normal saline (NS)
- Drug: intravenous (IV) prophylactic antibiotic
|
Interventional
|
Phase 4 |
- The University of Texas Health Science Center, Houston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Number of participants with surgical site infection (SSI)
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT03483363 |
HSC-DB-18-0038 |
|
October 9, 2018 |
March 2022 |
March 2022 |
March 30, 2018 |
December 11, 2018 |
|
- The University of Texas Health Science Center at Houston
Houston, Texas, United States
|
|
| 59 |
NCT03674775 |
Not yet recruiting |
Reducing Antibiotic Prescribing in Family Practice |
- Acute Respiratory Tract Infection
|
- Other: DART QI Program Participation
|
Interventional
|
Not Applicable |
- Seattle Children's Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Overall antibiotic prescribing rates for pediatric and adult ARTIs.
- First-line antibiotic prescribing rates for pediatric and adult bacterial ARTIs.
- Net cost of delivering the DART QI program
|
180 |
All |
6 Months and older (Child, Adult, Older Adult) |
NCT03674775 |
371934 |
|
July 2019 |
January 2022 |
June 2023 |
September 18, 2018 |
September 24, 2018 |
|
|
|
| 60 |
NCT02809131 |
Recruiting |
Perioperative Antibiotic Therapy to Prevent Cardiac Implantable Electronic Device Infections. |
- Sick Sinus Syndrome
- Complete Heart Block
- Syncope
- Chronic Systolic Heart Failure
|
- Drug: polymixin/bacitracin
- Drug: cephalexin, or levofloxacin, or clindamycin
- Drug: Saline
|
Interventional
|
Phase 3 |
- Vanderbilt University Medical Center
- Thomas Jefferson University
- The Cooper Health System
- (and 2 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of patients with a major CIED infection
- Number of patients with a minor CIED infection
|
1492 |
All |
18 Years and older (Adult, Older Adult) |
NCT02809131 |
150753 |
ENVELOPE |
April 2016 |
June 2019 |
June 2019 |
June 22, 2016 |
April 3, 2018 |
|
- Vanderbilt University Medical Center
Nashville, Tennessee, United States - Vanderbilt University Medical Center
Nashville, Tennessee, United States
|
|
| 61 |
NCT03761043 |
Recruiting |
Nurse Promotion of IV to PO Antimicrobial Conversion |
- Behavior Change
- Bacterial Infections
|
- Behavioral: Professional Behavior Change Intervention
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- IV to PO antimicrobial conversion rate
- Days of IV therapy prior to conversion to PO antimicrobial
- Nurse perceptions of capability, opportunity and motivation to promote IV to PO antimicrobial conversion
|
276 |
All |
19 Years and older (Adult, Older Adult) |
NCT03761043 |
IH1803202 |
FERN-IPO |
January 7, 2019 |
April 2019 |
April 2019 |
December 3, 2018 |
January 15, 2019 |
|
- Kelowna General Hospital
Kelowna, British Columbia, Canada
|
|
| 62 |
NCT02795949 |
Recruiting |
Study on Reduced Antibiotic Treatment vs Broad Spectrum Betalactam in Patients With Bacteremia by Enterobacteriaceae |
- Enterobacteriaceae Infections
|
- Drug: Antipseudomonal beta-lactam antibiotic
- Drug: De-escalation(short-spectrum antibiotic)
|
Interventional
|
Phase 3 |
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
- Spanish Network for Research in Infectious Diseases
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical cure at day 3-5 after treatment.
- Early clinical and microbiological response.
- Late clinical and microbiological response.
- (and 7 more...)
|
344 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT02795949 |
SIMPLFY |
SIMPLIFY |
October 2016 |
January 2020 |
February 2020 |
June 10, 2016 |
May 14, 2018 |
|
- Jerez de la Frontera Hospital
Jerez de la Frontera, Cádiz, Spain - La Línea de La Concepción Hospital
La Línea de La Concepción, Cádiz, Spain - University Hospital Donostia
San Sebastian, Gipúzcoa, Spain - (and 18 more...)
|
|
| 63 |
NCT03397433 |
Recruiting |
ANti-infective Stewardship Using the Wisca Tool in the Electronic Medical Record |
|
- Other: Information Technology physician assist
|
Interventional
|
Not Applicable |
- NorthShore University HealthSystem Research Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Changes in length of stay
- Rapid response to initial therapy
- Reduced cost of ancillary testing
- (and 7 more...)
|
6000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03397433 |
EH13-368 |
ANSWER |
June 2015 |
July 2018 |
October 2018 |
January 12, 2018 |
January 12, 2018 |
|
- NorthShore University HealthSystem Research Institute
Evanston, Illinois, United States
|
|
| 64 |
NCT03615807 |
Recruiting |
Less Infections for the Diabetic Foot |
|
- Procedure: Surgical debridement (if needed)
- Diagnostic Test: Microbiological sampling
- Procedure: Revascularisation (if needed).
- (and 4 more...)
|
Interventional
|
Not Applicable |
- University Hospital, Geneva
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Clinical evaluation
- Standard x-rays
- Wound Score
- (and 3 more...)
|
150 |
All |
18 Years to 120 Years (Adult, Older Adult) |
NCT03615807 |
n° 2016-01008 |
|
March 1, 2017 |
July 31, 2019 |
October 31, 2019 |
August 6, 2018 |
August 6, 2018 |
|
- Geneva University Hospitals
Geneva, Switzerland - Geneva University Hospitals
Geneva, Switzerland
|
|
| 65 |
NCT03349567 |
Recruiting |
Improving Antimicrobial-Prescribing in Emergency Departments |
- Anti-Bacterial Agents
- Respiratory Tract Infections
|
- Behavioral: Audit-and-feedback
|
Interventional
|
Not Applicable |
- Iowa City Veterans Affairs Medical Center
- Merck Sharp & Dohme Corp.
|
U.S. Fed / Industry |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Change in antimicrobial-prescribing volume
- Guideline-discordant antimicrobial use
- Late antimicrobial prescription
- (and 3 more...)
|
60 |
All |
Child, Adult, Older Adult |
NCT03349567 |
201708772 |
|
October 9, 2018 |
October 31, 2019 |
December 31, 2019 |
November 21, 2017 |
October 9, 2018 |
|
- Richard Roudebush VAMC
Indianapolis, Indiana, United States - Sioux Falls VA
Sioux Falls, South Dakota, United States
|
|
| 66 |
NCT03226626 |
Not yet recruiting |
Tumescent Anesthesia Antibiotic Delivery (TAAD) |
- Surgical Site Infection
- Thrombosis
- Sepsis
|
- Drug: Tumescent Anesthesia and antibiotic delivery (TAAD) plus IVAD
- Device: SubQKath
|
Interventional
|
Phase 2
Phase 3 |
- HK Surgical, Inc.
- University of California, Riverside
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Prevention
|
- surgical site infection (SSI)
- Post-operative venous thromboembolism
- Sepsis
- (and 6 more...)
|
330 |
All |
18 Years and older (Adult, Older Adult) |
NCT03226626 |
TAAD |
TAAD |
January 1, 2018 |
January 1, 2021 |
December 31, 2021 |
July 24, 2017 |
January 3, 2018 |
|
|
|
| 67 |
NCT03357419 |
Not yet recruiting |
The Effect of Prophylactic Antibiotics on Surgical Site Infection Lower Limb Skin Excisions |
|
- Drug: Cephalexin
- Drug: Placebo oral capsule
|
Interventional
|
Not Applicable |
- Rambam Health Care Campus
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- The primary end point is absence of infection after 1 month follow-up.
|
325 |
All |
18 Years and older (Adult, Older Adult) |
NCT03357419 |
0569-17 RMB |
|
January 2019 |
January 2019 |
January 2020 |
November 29, 2017 |
May 30, 2018 |
|
- Department of Plastic Surgery, Rambam Medical Center
Haifa, Israel
|
|
| 68 |
NCT03732365 |
Not yet recruiting |
Phase 2 Randomized Study to Compare Ultrasonic Drug Delivery to Standard of Care for the Treatment of Infections in Non-Healing Wounds |
- Acute Bacterial Skin and Skin Structure Infection (ABSSSI)
- Non-healing Wound
|
- Combination Product: Ultrasonic Drug Delivery
- Drug: Standard of Care Antibiotic Treatment
|
Interventional
|
Phase 2 |
- Sonescence, Inc.
- University of Southern California
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Wound healing and eligibility for grafting
- Reduction or elimination of pain
- Clinical signs and symptoms of infection will be assessed
|
30 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03732365 |
SON2018-001 |
|
February 1, 2019 |
January 31, 2020 |
July 31, 2020 |
November 6, 2018 |
November 6, 2018 |
|
|
|
| 69 |
NCT03338738 |
Recruiting |
Impact of Beta-lactams on the Microbiota and Relative Fecal Abundance of Mulltidrug Resistant Bacteria |
- Enterobacterial Infection
|
- Diagnostic Test: Stool culture ans swab
|
Interventional
|
Not Applicable |
- Groupe Hospitalier Paris Saint Joseph
- Hospital Avicenne
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03338738 |
COPROBLSE |
|
July 19, 2018 |
July 31, 2020 |
December 31, 2020 |
November 9, 2017 |
August 8, 2018 |
|
- Groupe Hospitalier Paris Saint Joseph
Paris, Ile-de-France, France
|
|
| 70 |
NCT03558984 |
Not yet recruiting |
Efficacy and Safety of D-PLEX in the Prevention of Sternal Infection Post Cardiac Surgery |
- Surgical Site Infection
- Open Heart Surgery
|
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Infection rate
- Hospitalization days
- Deep Surgical Wound Infection (DSWI) rates
- (and 5 more...)
|
1600 |
All |
18 Years and older (Adult, Older Adult) |
NCT03558984 |
D-PLEX 302 |
|
November 1, 2018 |
December 31, 2020 |
March 31, 2021 |
June 15, 2018 |
June 15, 2018 |
|
- Soroka Medical Center
Beer Sheva, Israel
|
|
| 71 |
NCT03520010 |
Recruiting |
Facilitated Implementation of Antibiotic Stewardship in Wisconsin Nursing Homes |
- UTI - Urinary Tract Infection
|
- Behavioral: Externally-facilitated implementation
- Behavioral: Internally-driven implementation
|
Interventional
|
Not Applicable |
- University of Wisconsin, Madison
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Urine culture orders per 1,000 resident-days
- Antibiotic starts for treatment of suspected UTI per 1,000 resident-days
- Days of therapy for treatment of suspected UTI per 1,000 resident-days
- (and 7 more...)
|
420 |
All |
18 Years and older (Adult, Older Adult) |
NCT03520010 |
2018-0125 |
IMUNIFI |
June 1, 2018 |
March 31, 2020 |
August 31, 2020 |
May 9, 2018 |
October 16, 2018 |
|
- University of Wisconsin-Madison
Madison, Wisconsin, United States
|
|
| 72 |
NCT02789579 |
Recruiting |
The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy |
- Complication of Surgical Procedure
|
- Drug: levofloxacin
- Drug: Nitrofurantoin
- Drug: cefuroxime
|
Interventional
|
Early Phase 1 |
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Evidence of clinically urinary tract infection confirmed by laboratory examination or urine bacterial culture.
- Evidence of clinically urosepsis confirmed by laboratory examination, urine bacterial culture, and vital signs
|
150 |
All |
16 Years to 75 Years (Child, Adult, Older Adult) |
NCT02789579 |
XH-16-010 |
|
September 2016 |
December 2018 |
December 2018 |
June 3, 2016 |
May 11, 2018 |
|
- Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University School of Medicine.Kongjiang Road 1665,
Shanghai, Shanghai, China
|
|
| 73 |
NCT02380352 |
Recruiting |
Short-course Antimicrobial Therapy for Paediatric Respiratory Infections |
- Community-acquired Pneumonia
|
- Drug: Amoxicillin
- Drug: Placebo
|
Interventional
|
Phase 4 |
- Hamilton Health Sciences Corporation
- Children's Hospital of Eastern Ontario
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Early clinical cure (Resolution of tachypnoea, increased work of breathing, and fever)
- Days of adverse reactions
- Days of missed school
- (and 2 more...)
|
270 |
All |
6 Months to 10 Years (Child) |
NCT02380352 |
SAFER 001 PSI |
SAFER |
September 2016 |
August 2019 |
November 2019 |
March 5, 2015 |
August 9, 2018 |
|
- McMaster Children's Hospital
Hamilton, Ontario, Canada - Children's Hospital of Eastern Ontario
Ottawa, Ontario, Canada
|
|
| 74 |
NCT03176563 |
Recruiting |
Observational Follow-up Study of REGATTA |
|
- Drug: Arctuvan
- Drug: Placebo to Fosfomycin
- Drug: Fosfomycin
- Drug: Placebo to Arctuvan
|
Observational
|
|
- University Medical Center Goettingen
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- number of urinary tract infections
- number of pyelonephritis
|
430 |
Female |
18 Years to 75 Years (Adult, Older Adult) |
NCT03176563 |
01970 |
REGATTA II |
May 3, 2017 |
May 2019 |
July 2020 |
June 5, 2017 |
June 8, 2017 |
|
- General Practice Aden
Braunschweig, Germany - General Practice Scheffer
Braunschweig, Germany - General Practice Coutelle
Bremen, Germany - (and 31 more...)
|
|
| 75 |
NCT03140085 |
Recruiting |
Bacteriophages for Treating Urinary Tract Infections in Patients Undergoing Transurethral Resection of the Prostate |
- Intravesical Bacteriophage Treatment for Urinary Tract Infections
|
- Biological: PYO Phage
- Drug: Antibiotics
- Other: Sterile bacteriology media
|
Interventional
|
Phase 2
Phase 3 |
- Balgrist University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Normalisation of urine culture
- Urine culture
- Bladder diary
- (and 2 more...)
|
81 |
All |
18 Years and older (Adult, Older Adult) |
NCT03140085 |
02/283 |
|
November 1, 2015 |
December 31, 2017 |
December 31, 2017 |
May 4, 2017 |
May 8, 2017 |
|
- National Center of Urology
Tbilisi, Georgia
|
|
| 76 |
NCT03009045 |
Recruiting |
Tolerability, Safety, and Efficacy of Tedizolid as Oral Treatment for Bone and Joint Infections |
|
|
Interventional
|
Phase 2 |
- Los Angeles Biomedical Research Institute
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of "moderate" or "serious" adverse events as assessed by MedDRA v18.1
- Number of participants with an outcome of "cure" as defined as no need for further antibiotics beyond the originally planned duration determined by the participant's primary/treating physician.
- Number of participants with treatment-related adverse events as assessed by MedDRA v18.1
|
55 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT03009045 |
21814-01 |
|
February 6, 2017 |
July 2018 |
January 2019 |
January 4, 2017 |
May 15, 2018 |
|
- Harbor-UCLA Medical Center
Torrance, California, United States - Los Angeles BioMedical Research Institute (LA BioMed)
Torrance, California, United States
|
|
| 77 |
NCT00514098 |
Recruiting |
Observational Study of HIV Infected Women Previously Enrolled in Other Microbicide Trials |
|
|
Observational
|
|
- Microbicide Trials Network
- National Institute of Allergy and Infectious Diseases (NIAID)
- Microbicide Trials Network
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- HIV disease progression comparison
- Virologic and immunologic response comparison
- HIV-1 drug resistance profile comparison
- Sexual behavior and partnership status changes
|
500 |
Female |
Child, Adult, Older Adult |
NCT00514098 |
MTN-015
5UM1AI068633
10529 |
|
August 2008 |
November 2020 |
November 2020 |
August 9, 2007 |
August 30, 2017 |
|
- College of Med. JHU CRS
Blantyre, Malawi - University of North Carolina Lilongwe
Lilongwe, Malawi - Wits Reproductive Health Institute (WRHI)
Johannesburg, Gauteng, South Africa - (and 15 more...)
|
|
| 78 |
NCT03147807 |
Recruiting |
BetaLACTA® Test for Early De-escalation of Empirical Carbapenems in Pulmonary, Urinary and Bloodstream Infections in ICU |
- Pneumonia
- Urinary Tract Infections
- Bloodstream Infection
|
- Device: betaLACTA® rapid diagnostic test
|
Interventional
|
Not Applicable |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- mortality at D90 and infection recurrence during the ICU stay
- Exposure to carbapenems
- Total use of ICU and hospital resources and cost-effectiveness of early de-escalation compared to standard de-escalation.
- (and 5 more...)
|
646 |
All |
18 Years and older (Adult, Older Adult) |
NCT03147807 |
P 150940
N° IDRCB 2016-A00941-50 |
BLUE-CarbA |
October 20, 2017 |
November 20, 2019 |
January 20, 2020 |
May 10, 2017 |
February 27, 2018 |
|
- Anesthesiology and Critical Care Medicine Department
Paris, France
|
|
| 79 |
NCT03081962 |
Recruiting |
Effect of a Combination of Bundles on Surgical-site Infection After Elective Colorectal Surgery |
|
- Drug: Bundle
- Procedure: Standard care
|
Interventional
|
Phase 3 |
- Hospital General Universitario Elche
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- Incisional surgical site infection
|
102 |
All |
Child, Adult, Older Adult |
NCT03081962 |
HGUE-2016-23 |
|
February 15, 2017 |
August 2017 |
August 2017 |
March 17, 2017 |
June 27, 2017 |
|
- General Hospital Elche
Elche, Alicante, Spain
|
|
| 80 |
NCT03187106 |
Recruiting |
Prophylactic Antibiotics After Cesarean |
|
- Drug: Cephalexin
- Drug: Placebo
- Drug: Metronidazole
|
Interventional
|
Phase 1 |
- The University of Texas Medical Branch, Galveston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Surgical site infection
- Maternal mortality
- Febrile morbidity
- (and 4 more...)
|
332 |
Female |
18 Years to 50 Years (Adult) |
NCT03187106 |
17-0035 |
PAC |
August 1, 2017 |
June 5, 2020 |
June 5, 2020 |
June 14, 2017 |
February 15, 2019 |
|
- St. David's North Austin Medical Center
Austin, Texas, United States - University of Texas Medical Branch John Sealy Hospital
Galveston, Texas, United States
|
|
| 81 |
NCT03372941 |
Not yet recruiting |
Hospital Avoidance Strategies for ABSSSI |
|
|
Interventional
|
Phase 4 |
- Washington University School of Medicine
- Barnes-Jewish Hospital
- Allergan
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Healthcare utilization related to ABSSSI
- Healthcare cost related to ABSSSI management
- Clinical response
- (and 5 more...)
|
120 |
All |
18 Years and older (Adult, Older Adult) |
NCT03372941 |
201709136 |
|
November 1, 2018 |
September 1, 2019 |
December 1, 2019 |
December 14, 2017 |
October 3, 2018 |
|
|
|
| 82 |
NCT03148444 |
Not yet recruiting |
Impact of Antibiotic Treatment Following Implantation of Cardiac Electronic Device on Patient's Outcome |
- Infection, Bacterial
- Pacemaker Complication
|
- Drug: cefalexin 500 mg qid or roxithromycin 150 mg bid
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- wound infection
- bacteremia and vegetations
- re-operation
- (and 4 more...)
|
400 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03148444 |
kmc 0038-16 |
|
June 1, 2017 |
June 1, 2019 |
June 1, 2020 |
May 11, 2017 |
May 11, 2017 |
|
|
|
| 83 |
NCT02359331 |
Recruiting |
The Efficacy of the 7 Days Tailored Therapy as 2nd Rescue Therapy for Eradication of H. Pylori Infection |
|
- Procedure: H. pylori culture and antimicrobial susceptibility testing
- Drug: 14 days empirical bismuth quadruple therapy (Proton pump inhibitor)
- Drug: Metronidazole
- (and 5 more...)
|
Interventional
|
Not Applicable |
- Seoul National University Bundang Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Compare the percentage of participants with successful H. pylori eradication in each groups
|
370 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT02359331 |
B1408/285-005 |
|
August 2014 |
November 2020 |
December 2020 |
February 10, 2015 |
April 18, 2018 |
|
- Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, Korea, Republic of
|
|
| 84 |
NCT03244917 |
Recruiting |
Trial to Reduce Antimicrobial Use In Nursing Home Residents With Alzheimer's Disease and Other Dementias |
- Dementia
- Infection, Bacterial
|
|
Interventional
|
Not Applicable |
- Hebrew Rehabilitation Center, Boston
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Health Services Research
|
- Total antimicrobial use
- Antimicrobial use when minimal criteria are absent
- Burdensome interventions
- Advance care planning
|
480 |
All |
21 Years and older (Adult, Older Adult) |
NCT03244917 |
TRAIN-AD |
TRAIN-AD |
October 15, 2017 |
August 2020 |
March 2021 |
August 10, 2017 |
November 14, 2017 |
|
- Hebrew SeniorLife
Boston, Massachusetts, United States
|
|
| 85 |
NCT03745014 |
Not yet recruiting |
Clinical Impact of Fast Phenotypic Antimicrobial Susceptibility Testing on Patients With Bacteremic Urinary Tract Infections |
|
- Diagnostic Test: Accelerate Pheno
- Diagnostic Test: Standard of Care
|
Interventional
|
Not Applicable |
- Accelerate Diagnostics, Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Desirability of Outcome Ranking (DOOR) - composite outcome
|
420 |
All |
18 Years and older (Adult, Older Adult) |
NCT03745014 |
ECP000002 |
|
December 15, 2018 |
December 15, 2019 |
January 31, 2020 |
November 19, 2018 |
November 19, 2018 |
|
|
|
| 86 |
NCT02951481 |
Recruiting |
Antimicrobial Stewardship Program for Clostridium Difficile Infection. |
- Clostridium Difficile
- Enterocolitis, Pseudomembranous
|
- Behavioral: Systematic evaluation by an ID expert.
|
Observational
|
|
- José María Aguado García, MD, PhD
- Hospital Universitario 12 de Octubre
- Merck Sharp & Dohme Corp.
|
Other / Industry |
- Observational Model: Cohort
- Time Perspective: Other
|
- Rate of Clostridium difficile infection recurrence.
- Compliment with clinical practice guidelines for treatment of C. difficile infection.
- Patients with antimicrobial adjustment.
- (and 2 more...)
|
100 |
All |
18 Years to 110 Years (Adult, Older Adult) |
NCT02951481 |
JMA-MET-2016-01 |
PACTA-ICD |
February 8, 2017 |
March 2018 |
December 2018 |
November 1, 2016 |
March 3, 2017 |
|
- Unidad de Enfermedades Infecciosas. Hospital Universitario 12 de Octubre
Madrid, Spain
|
|
| 87 |
NCT03221140 |
Recruiting |
Outpatient Parenteral Antimicrobial Therapy (OPAT) |
|
- Drug: Outpatient parenteral antimicrobial therapy
|
Observational
|
|
- University of Lausanne Hospitals
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Evaluation of treatment outcomes
- Evaluation of the incidence of adverse events
- Economic evaluation
|
2000 |
All |
18 Years and older (Adult, Older Adult) |
NCT03221140 |
34/14 |
|
January 1, 2014 |
December 31, 2020 |
December 31, 2021 |
July 18, 2017 |
July 25, 2017 |
|
- Department of Outpatient Care and Community Medicine, University Hospital of Lausanne
Lausanne, Switzerland
|
|
| 88 |
NCT02599493 |
Recruiting |
EVRIOS : Comparative Evaluation of Low Versus High Doses of Rifampicin |
|
|
Interventional
|
Phase 4 |
- Rennes University Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proven failure
- Possible failure
- Adverse events
- (and 6 more...)
|
460 |
All |
18 Years and older (Adult, Older Adult) |
NCT02599493 |
35RC14_9741_EVRIOS
2015-001519-11
150790A-41
15/18-980 |
EVRIOS |
January 2016 |
January 2019 |
January 2020 |
November 6, 2015 |
April 9, 2018 |
|
- Angers university hospital
Angers, France - Bordeaux university hospital
Bordeaux, France - Brest university hospital
Brest, France - (and 16 more...)
|
|
| 89 |
NCT02590198 |
Recruiting |
Diagnostic Performance Comparison Between Procalcitonin-based vs. ANAES-based Guidelines |
- Early-onset Neonatal Infection
|
- Other: ANAES algorithm
- Other: PCT algorithm
|
Observational
|
|
- Nantes University Hospital
- University Hospital, Tours
- University Hospital, Brest
- (and 8 more...)
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Primary outcome is a composite outcome including: death from any cause, intensive care unit admission for any reason, disease-specific complications, diagnosis of EONI after maternity discharge, need for antibiotics with hospital readmission
- death
- NICU admission
- (and 6 more...)
|
8928 |
All |
Child, Adult, Older Adult |
NCT02590198 |
RC15_0063 |
DIACORD |
May 3, 2016 |
August 2017 |
August 2017 |
October 28, 2015 |
July 11, 2017 |
|
- Angers University Hospital
Angers, France - Bordeaux University Hospital
Bordeaux, France - Brest University Hospital
Brest, France - (and 11 more...)
|
|
| 90 |
NCT03560232 |
Recruiting |
Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens |
- Open Fracture
- Post-Op Wound Infection
|
- Drug: Ceftriaxone
- Drug: Ampicillin/sulbactam
- Drug: Piperacillin/tazobactam
- (and 2 more...)
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Post-surgical site wound infections
- Incidence of acute kidney injury
- Average cost of antibiotic therapy per patient
- Time to antibiotic therapy
|
320 |
All |
18 Years and older (Adult, Older Adult) |
NCT03560232 |
17-028 |
|
July 9, 2018 |
June 2020 |
June 2020 |
June 18, 2018 |
August 31, 2018 |
|
- St. Joseph Warren Hospital
Warren, Ohio, United States - St. Elizabeth Youngstown Hospital
Youngstown, Ohio, United States
|
|
| 91 |
NCT03736187 |
Not yet recruiting |
Antibiotics for Prevention of SSI in Obese Women Undergoing CS |
|
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
|
280 |
Female |
Child, Adult, Older Adult |
NCT03736187 |
Antibiotics for SSI |
|
April 2019 |
October 2019 |
December 2019 |
November 9, 2018 |
November 9, 2018 |
|
|
|
| 92 |
NCT02920463 |
Recruiting |
DetermInants of Antimicrobial Use aNd De-escalAtion in Critical Care (DIANA) |
|
|
Observational
|
|
- University Hospital, Ghent
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Number of patients in which the empirical antibiotic therapy is de-escalated
- Proportion of patients with clinical cure at day 7 in de-escalated patients versus non-deescalated patients
- Antibiotics used in empirical antimicrobial therapy in critically ill patients
- (and 10 more...)
|
2500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02920463 |
EC/2016/0938 |
DIANA |
October 2016 |
July 2018 |
July 2018 |
September 30, 2016 |
May 21, 2018 |
|
- Ghent University Hospital
Ghent, Belgium
|
|
| 93 |
NCT03574090 |
Not yet recruiting |
Study the Efficacy of Topical Antibiotherapy in the Prophylaxis of Incisional Surgical Infection in Urgent Surgery |
- Surgical Wound Infection
- Postoperative Wound Infection
- Postoperative Wound Infection Superficial Incisional
- Preventive Therapy
|
- Drug: Amoxicillin Clavulanate
- Drug: Physiological Saline
|
Interventional
|
Phase 4 |
- Universitat Internacional de Catalunya
- Hospital de Granollers
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- Evaluation of the effect of topical antibiotic prophylaxis on the incidence of SSI
- reduction of hospital stay
- Bacterial charge
- Bacterial resistance
|
140 |
All |
18 Years and older (Adult, Older Adult) |
NCT03574090 |
1234 |
PROFITOP |
July 15, 2018 |
June 15, 2020 |
August 15, 2020 |
June 29, 2018 |
June 29, 2018 |
|
|
|
| 94 |
NCT03462459 |
Recruiting |
Efficacy of Oral Vancomycin Prophylaxis for Prevention of Recurrent Clostridium Difficile Infection |
- Recurrent Clostridium Difficile Infection
- Clostridium Difficile Infection
|
- Drug: Vancomycin
- Drug: Placebo
|
Interventional
|
Phase 2 |
- University of Wisconsin, Madison
- Indiana University
- Medical College of Wisconsin
- Agency for Healthcare Research and Quality (AHRQ)
|
Other / U.S. Fed |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Prevention
|
- Recurrent Clostridium difficile infection (CDI)
- Gut microbiome composition
- Vancomycin-resistant enterococcus (VRE) colonization in patients receiving vancomycin vs. placebo
- Determine whether Clostridium difficile positivity on any stool sample is a predictor of CDI recurrence.
|
150 |
All |
18 Years and older (Adult, Older Adult) |
NCT03462459 |
2017-0927
1R01HS025713-01 |
|
May 21, 2018 |
December 31, 2021 |
December 31, 2021 |
March 12, 2018 |
June 20, 2018 |
|
- University of Wisconsin-Madison
Madison, Wisconsin, United States
|
|
| 95 |
NCT03759886 |
Not yet recruiting |
Oral Antibiotic Prophylaxis in Colorectal Surgery |
- Surgical Site Infection
- Anastomotic Leak
|
- Drug: Paromomycin Sulfate Powder
|
Observational
|
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Surgical Site Infections
- Anastomotic Leak
|
100 |
All |
18 Years and older (Adult, Older Adult) |
NCT03759886 |
ABCR |
ABCR |
November 2018 |
September 2019 |
December 2019 |
November 30, 2018 |
November 30, 2018 |
|
- Universitätsklinikum Leipzig - AöR
Leipzig, Sachsen, Germany
|
|
| 96 |
NCT03809117 |
Recruiting |
Film Array Gastrointestinal Panel Compared to Usual Care for ED Evaluation of Infectious Diarrhea |
|
- Diagnostic Test: Biofire Film Array Gastrointestinal Panel
|
Interventional
|
Not Applicable |
- Andrew Meltzer
- BioFire Diagnostics, LLC
- George Washington University
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Rate of Optimal Use of Antibiotics
- Time to Resolution of Symptoms/Clinical Improvement
- Rate of appropriate use of anti-motility medications
- (and 9 more...)
|
176 |
All |
18 Years and older (Adult, Older Adult) |
NCT03809117 |
IRB #051839 |
|
November 19, 2018 |
August 19, 2019 |
November 19, 2019 |
January 18, 2019 |
January 18, 2019 |
|
- The George Washington University, Department of Emergency Medicine
Washington, District of Columbia, United States
|
|
| 97 |
NCT02996487 |
Recruiting |
Screening to Prophylax Against Clostridium Difficile Infection - |
- Clostridium Difficile Infection
|
- Drug: Vancomycin
- Other: Placebo
|
Interventional
|
Phase 4 |
- William Beaumont Hospitals
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Prevention
|
- The incidence of CDI in inpatients receiving vancomycin prophylaxis vs. placebo who are on high-risk antibiotics and are colonized with toxigenic C. difficile.
- The severity of CDI in patients receiving vancomycin prophylaxis vs. placebo.
- The outcome of CDI in patients receiving vancomycin prophylaxis vs. placebo.
- (and 2 more...)
|
2500 |
All |
18 Years and older (Adult, Older Adult) |
NCT02996487 |
2016-254 |
StoP CDI |
December 2016 |
September 2020 |
September 2021 |
December 19, 2016 |
September 28, 2018 |
|
- William Beaumont Hospital
Royal Oak, Michigan, United States
|
|
| 98 |
NCT03832465 |
Not yet recruiting
New |
Intraluminal Mono-antibiotic Therapy for Helicobacter Pylori Infection - A Comparison of Levofloxacin Powder and Levofloxacin Solution |
- Helicobacter Pylori Infection
|
- Drug: Levofloxacin film-coated tablet
- Drug: Levofloxacin intravenous solution
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Eradication rate of the intraluminal Levofloxacin therapy
- Incidence of adverse effects of the intraluminal Levofloxacin therapy
- Eradication rates of 7-day or 14-day levofloxacin-containing triple therapy
- The overall eradication rate
|
50 |
All |
20 Years to 75 Years (Adult, Older Adult) |
NCT03832465 |
18MMHIS168 |
|
February 15, 2019 |
August 14, 2020 |
January 27, 2021 |
February 6, 2019 |
February 15, 2019 |
|
- Division of Gastroenterology and Department of Internal Medicine, Mackay Memorial Hospital, Taipei, Taiwan
Taipei, Taiwan
|
|
| 99 |
NCT03248349 |
Recruiting |
Population Pharmacokinetics of Antibiotics in Critically Ill Children (POPSICLE) |
- Critical Illness
- Infectious Disease
- Children
|
|
Observational
|
|
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Volume of distribution of antibiotics in critically ill children
- Clearance of antibiotics in critically ill children
|
200 |
All |
up to 18 Years (Child, Adult) |
NCT03248349 |
2016-3085 |
POPSICLE |
May 24, 2017 |
May 1, 2020 |
October 1, 2020 |
August 14, 2017 |
August 31, 2018 |
|
- Radboudumc
Nijmegen, Gelderland, Netherlands
|
|
| 100 |
NCT03840603 |
Not yet recruiting
New |
Impact on PCT+ FilmArray RP2 Plus Use in LRTI Suspicion in Emergency Department |
- Respiratory Tract Infections
|
- Diagnostic Test: Film Array RP2 Assay guided
|
Interventional
|
Not Applicable |
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Diagnostic
|
- Duration of total antibiotic exposure
- Initiation of an antibiotic therapy
- Protocol "failure" within 15 days of randomization
|
444 |
All |
18 Years and older (Adult, Older Adult) |
NCT03840603 |
2018-A02173-52 |
PROARRAY |
June 1, 2019 |
July 1, 2020 |
January 1, 2021 |
February 15, 2019 |
February 15, 2019 |
|
|
|
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