11 studies found for:    Thalassemias | Open Studies | NIH, U.S. Fed
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Thalassemias | Open Studies | NIH, U.S. Fed (11 records)
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Rank Status Study
1 Recruiting Nonmyeloablative Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Sickle Cell Disease and Beta-thalassemia in People With Higher Risk of Transplant Failure
Conditions: Sickle Cell Disease;   Thalassemia;   Stem Cell Transplantation;   Graft vs Host Disease
Interventions: Drug: Alemtuzumab;   Drug: Sirolimus;   Drug: Cyclophosphamide;   Drug: Pentostatin;   Drug: Radiotherapy
2 Recruiting Nonmyeloablative Haploidentical Peripheral Blood Mobilized Hematopoietic Precursor Cell Transplantation for Severe Congenital Anemias Including Sickle Cell Disease and Beta-Thalassemia
Conditions: Peripheral Blood Stem Cell Transplantation;   Anemia, Sickle Cell;   Graft-Versus-Host Disease;   Sirolimus (Rapamune );   Alemtuzumab (Campath )
Interventions: Procedure: PBMC Transplant;   Drug: Alemtuzumab (Campath  );   Drug: Sirolimus (Rapamune  );   Drug: Cyclophosphamide (Cytoxan  );   Procedure: Low Dose Irradiation
3 Recruiting Retroviral Vector Mediated Globin Gene Transfer to Correct Sickle Cell Anemia or Thalassemia
Conditions: Sickle Cell Anemia;   Thalassemia
Intervention: Genetic: Gene Therapy
4 Recruiting Improving the Results of Bone Marrow Transplantation for Patients With Severe Congenital Anemias
Conditions: Congenital Hemolytic Anemia;   Diamond-Blackfan Anemia
Interventions: Procedure: Radiotherapy;   Drug: Alemtuzumab (Campath  );   Drug: Sirolimus (Rapamune  )
5 Unknown  Effects of Transfusion of Older Red Blood Cells on Patients With Hemoglobinopathies
Conditions: Sickle Cell Disease;   Thalassemia
Intervention: Biological: Transfusion
6 Recruiting Topical Sodium Nitrite for Chronic Leg Ulcers in Adult Patients With Blood Disorders
Conditions: Sickle Cell Anemia;   Sickle Cell Disease;   Chronic Hemolytic Disorders
Intervention: Drug: Sodium Nitrite Cream
7 Recruiting Natural History of Sickle Cell Disease and Other Hemolytic Disorders
Conditions: Hemoglobin SC Disease;   Hematologic Diseases;   Sickle Cell Anemia;   Hemolytic Anemia
Intervention:
8 Recruiting Massive Iron Deposit Assessment
Conditions: Iron Overload;   Excessive Body Iron Burden
Interventions: Device: R2*-UTE;   Device: R2*-GRE;   Procedure: Liver biopsy
9 Recruiting Treosulfan and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Nonmalignant Inherited Disorders
Condition: Non-Malignant Disease
Interventions: Drug: Treosulfan;   Drug: Fludarabine Phosphate;   Biological: Anti-Thymocyte Globulin;   Radiation: Total-Body Irradiation;   Procedure: Allogeneic Bone Marrow Transplantation;   Procedure: Peripheral Blood Stem Cell Transplantation;   Procedure: Umbilical Cord Blood Transplantation;   Drug: Tacrolimus;   Drug: Methotrexate;   Drug: Cyclosporine;   Drug: Mycophenolate Mofetil;   Other: Laboratory Biomarker Analysis
10 Recruiting Secondary Pulmonary Hypertension in Adults With Sickle Cell Anemia
Conditions: Pulmonary Hypertension;   Sickle Cell Anemia;   Sickle Cell Disease
Intervention:
11 Recruiting Preventing Sickle Cell Kidney Disease
Conditions: Anemia, Sickle Cell;   Sickle Cell Disease;   Kidney Disease;   Hypertension;   Proteinuria
Intervention: Drug: Losartan

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