23 studies found for:    SNCA
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Rank Status Study
1 Recruiting Oligomeric Alpha-synuclein in Multiple System Atrophy
Condition: Multiple System Atrophy (MSA)
Intervention:
2 Active, not recruiting Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
Condition: Parkinson's Disease
Intervention: Drug: Glycerol Phenylbutyrate
3 Unknown  Alpha-synuclein in Cerebrospinal Fluid to Differentiate Alzheimer's Disease From Lewy Body Disease.
Condition: "Alzheimer's Disease" and "Lewy Body Disease"
Interventions: Other: MRI;   Procedure: lumbar puncture;   Behavioral: neuropsychological tests
4 Recruiting Biomarkers in Parkinsonian Syndromes
Conditions: Parkinsonian Syndromes;   Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy
Interventions: Other: CSF, blood and urine sampling;   Other: clinical measures of disease severity and progression
5 Active, not recruiting Usefulness of α-synuclein as a Marker for Early Diagnosis of Parkinson's Disease in Skin Biopsy.
Conditions: Parkinson Disease;   Parkinsonian Disorders
Intervention: Procedure: Biopsy of skin
6 Completed Analysis of the Enteric Nervous System Using Colonic Biopsies
Conditions: Parkinson's Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy
Intervention: Procedure: colonoscopy or rectosigmoidoscopy
7 Unknown  Diagnostic and Prognostic Biomarkers in Parkinson Disease
Conditions: Parkinson Disease;   Multiple System Atrophy;   Progressive Supranuclear Palsy
Intervention:
8 Recruiting Systemic Synuclein Sampling Study (S4)
Condition: Parkinson's Disease
Interventions: Procedure: Biofluid samplings;   Procedure: Tissue samplings;   Drug: DaTSCAN™
9 Recruiting Natural History Study of Synucleinopathies
Condition: Patients With Synucleinopathies
Intervention:
10 Terminated Early Parkinson's Disease (PD) Cross-Sectional
Condition: Parkinson's Disease
Intervention:
11 Withdrawn Study Assessing Tolerability and Safety and Exploring the Immunogenicity and Therapeutic Activity of AFFITOPE® PD01A in PD-GBA Patients
Condition: Parkinson's Disease
Interventions: Biological: AFFITOPE® PD01A + Adjuvant;   Biological: Adjuvant without active component
12 Recruiting Single-Ascending Dose Study of BIIB054 in Healthy Participants and Early Parkinson's Disease
Condition: Parkinson's Disease
Interventions: Drug: BIIB054;   Drug: Placebo
13 Completed Genetic Characterization of Parkinson's Disease
Conditions: Parkinson Disease;   PD;   Movement Disorder;   Healthy Volunteer;   HV
Intervention:
14 Completed Biological Markers in Parkinson's Disease
Condition: Parkinson Disease
Intervention:
15 Not yet recruiting Enteric Nervous System in Alzheimer Disease
Condition: Alzheimer Disease
Interventions: Procedure: Rectosigmoidoscopy with colonic biopsies;   Procedure: Colonoscopy with colonic biopsies
16 Recruiting Study of the Enteric Nervous System Using Colonic Biopsies in Parkinson Patients With LRRK2 Mutation
Condition: Parkinson's Disease
Intervention: Other: colonoscopy or rectosigmoidoscopy
17 Recruiting Retinal Abnormalities as Biomarker of Disease Progression and Early Diagnosis of Parkinson Disease
Conditions: Parkinson Disease;   Multiple System Atrophy;   REM Sleep Behavior Disorder;   Pure Autonomic Failure;   Dementia With Lewy Bodies
Intervention:
18 Completed Oculomotor Testing in the Differential Diagnosis of Dementia
Conditions: Lewy Body Disease;   Alzheimer's Disease
Intervention: Other: oculomotor measurements
19 Active, not recruiting Orthostatic Dysregulation and Associated Gastrointestinal Dysfunction in Parkinson's Disease -Treatment
Condition: Autonomic Disturbances in Parkinson`s Disease
Interventions: Drug: Pyridostigmine bromide;   Drug: fludrocortisone
20 Unknown  Clinical, Molecular and by Neuroimaging of LRRK2 Mutations
Condition: Parkinson's Disease
Intervention:

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Indicates status has not been verified in more than two years