12 studies found for:    SMPD1
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Rank Status Study
1 Completed Tolerability and Safety Study of Recombinant Human Acid Sphingomyelinase in Acid Sphingomyelinase Deficiency Patients
Condition: Human Acid Sphingomyelinase Deficiency
Intervention: Drug: Recombinant human acid sphingomyelinase
2 Terminated Safety Study of rhASM Enzyme Replacement Therapy in Adults With Acid Sphingomyelinase Deficiency (Niemann-Pick Disease)
Conditions: Acid Sphingomyelinase Deficiency;   Niemann-Pick Disease
Intervention: Drug: rhASM
3 Recruiting Detection of Acid Sphingomyelinase/Ceramide Pathway Activation in Radiotherapy Patients Using Intravoxel Incoherent Motion (IVIM) Diffusion-weighted Magnetic Resonance Imaging and Serum Biomarkers
Conditions: Metastatic Disease to Bone;   Metastatic Disease to Soft Tissue
Interventions: Device: MRI with IVIM DW-MRI;   Other: Blood draw
4 Recruiting A Long-Term Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency
Condition: Sphingomyelin Lipidosis
Intervention: Drug: GZ402665
5 Recruiting Efficacy, Safety, Pharmacodynamic, and Pharmacokinetics Study of Olipudase Alfa in Patients With Acid Sphingomyelinase Deficiency
Condition: Sphingomyelin Lipidosis
Interventions: Drug: placebo (saline);   Drug: GZ402665
6 Completed Influence of Probiotic VSL#3 Administration on Metabolic and Immunological Profile of the Milk of Breastfeeding Mothers
Condition: Allergy
Interventions: Dietary Supplement: VSL#3 probiotic preparation;   Other: Placebo VSL#3
7 Recruiting Safety, Tolerability, PK, and Efficacy Evaluation of Repeat Ascending Doses of Olipudase Alfa in Pediatric Patients <18 Years of Age With Acid Sphingomyelinase Deficiency
Condition: Sphingomyelin Lipidosis
Intervention: Drug: Olipudase alfa
8 Recruiting Modulation of the Intestinal Flora With the Probiotic VIVOMIXX™ in Pregnant Women at Risk of Metabolic Complications
Conditions: Gestational Diabetes Mellitus in Pregnancy, Diet- Controlled;   Exercise Addiction;   High-Risk Pregnancy;   Dietary Modification
Interventions: Dietary Supplement: Probiotic VIVOMIXX™;   Dietary Supplement: Placebo
9 Completed Role of Sphingolipids in Pulmonary Edema
Condition: Pulmonary Edema
Intervention:
10 Not yet recruiting Mesenchymal Stem Cell Therapy for Bronchopulmonary Dysplasia in Preterm Babies
Condition: Bronchopulmonary Dysplasia
Intervention: Biological: Mesenchymal Stem Cell (MSC) therapy
11 Unknown  Anti-inflammatory Pulmonal Therapy of Cystic Fibrosis (CF) Patients With Amitriptyline and Placebo
Conditions: Cystic Fibrosis;   Pneumonia
Interventions: Drug: Amitriptyline;   Drug: Mannite
12 Suspended Rituximab to Prevent Recurrence of Proteinuria
Conditions: FSGS;   Proteinuria
Intervention: Drug: Rituximab

Indicates status has not been verified in more than two years