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31 studies found for:    SLCO1B1
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Rank Status Study
1 Enrolling by invitation Integrating Pharmacogenetics In Clinical Care
Condition: Cardiovascular Disease
Intervention: Genetic: SLCO1B1 Genotype
2 Completed Influence of Organic Anion Transporting Polypeptide1B1(OATP1B1) Genotype on Rosuvastatin PK, PD and Lipid Profiles
Conditions: Organic Anion Transporting Polypeptide1B1 (OATP1B1);   Rosuvastatin
Intervention: Drug: Rosuvastatin
3 Completed Genetically Guided Statin Therapy
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Interventions: Genetic: Reporting for SLCO1B1*5 allele at randomization;   Genetic: Reporting for SLCO1B1*5 allele at the end;   Genetic: Genetic testing for SLCO1B1*5 allele
4 Completed
Has Results
Genetic Predictors of Variability in the Drug-drug Interaction Between Darunavir/Ritonavir and Pravastatin
Conditions: HIV Infections;   Hyperlipidemia
Interventions: Drug: Pravastatin;   Drug: Darunavir;   Drug: Ritonavir;   Other: Washout
5 Completed
Has Results
Influence of OATP1B1 and CYP2C9 Genotypes on the Pharmacokinetics of Bosentan Before and During Clarithromycin
Condition: VA Drug Interactions [VA Drug Interaction]
Intervention: Drug: Bosentan
6 Unknown  Study of Genetic Polymorphisms of Drug Transporters and Orphan Nuclear Receptors on Treatment Effects of Irinotecan
Conditions: Colorectal Neoplasms;   Secondary
Intervention: Drug: irinotecan
7 Completed Statin Therapy to Improve Medication Adherence
Conditions: Hypercholesterolemia;   HMG COA Reductase Inhibitor Adverse Reaction
Intervention: Genetic: Genetic testing and reporting for SLCO1B1*5 allele
8 Completed Influence of OATP1B1 and BRCP Genotype on Rosuvastatin PK, PD and Lipidomics in Hyperlipidemic Patients
Condition: Hypercholesterolemia
Intervention: Drug: Rosuvastatin
9 Completed Influence of the OATP1B1 and OATP1B3 Genotype on the Hepatic Uptake of Primovist®
Conditions: Pharmacokinetics;   MRI;   Liver;   Drug Transporter;   Gd-EOB-DTPA
Interventions: Drug: Primovist® 0,25 mmol/ml solution for injection;   Device: MRI
10 Recruiting Statin Distribution
Condition: Drug Distribution
Interventions: Drug: Pravastatin;   Drug: Simvastatin
11 Recruiting Drug Transporter Interaction Study PHENTRA_2015_KPUK
Condition: Healthy
Interventions: Drug: pitavastatin;   Drug: Metformin;   Drug: digoxin;   Drug: Adefovir;   Drug: sitagliptin
12 Completed A Study to Investigate the Effect of GSK1605786 on Hepatic Cytochrome P450, and BCRP and OATP1B1 Transport in Healthy Adult Subjects
Condition: Crohn's Disease
Intervention: Drug: GSK1605786
13 Recruiting Pharmacokinetics of Rosuvastatin and Atorvastatin in Pediatric Dyslipidemia Patients
Condition: Dyslipidemia
Interventions: Drug: Rosuvastatin;   Drug: Atorvastatin
14 Active, not recruiting A Drug-Drug Interaction Study to Evaluate the Effect of AL-794 on the Pharmacokinetics of Oseltamivir and JNJ-63623872
Condition: Influenza in Humans
Interventions: Drug: AL-794;   Drug: Oseltamivir;   Drug: Digoxin;   Drug: Midazolam;   Drug: Pitavastatin;   Drug: JNJ-63623872
15 Unknown  Effect of Genes on Rosuvastatin Therapy for Hyperlipidemia
Condition: Hyperlipidemia
Interventions: Drug: rosuvastatin,fenofibrate;   Genetic: CYP2C9, UGT1A1, UGT1A3, OATP2, BCRP
16 Completed Drug-drug Interaction Study of GSK1278863 With Pioglitazone, Rosuvastatin and Trimethoprim in Healthy Adult Volunteers
Condition: Anaemia
Interventions: Drug: GSK1278863 25 mg Tablet;   Drug: Pioglitazone 15 mg Tablet;   Drug: Rosuvastatin 10 mg Tablet;   Drug: Trimethoprim 100 mg Tablet
17 Completed Drug Interaction Between Colchicine and Calcineurin Inhibitors in Renal Graft Recipients
Condition: Renal Replacement Therapies
Interventions: Drug: cyclosporine+colchicine;   Drug: tacrolimus
18 Completed Validation Study of Multiple Probe Compounds for Drug Interaction Evaluation
Condition: Drug Interactions
Interventions: Drug: Caffeine;   Drug: Rosiglitazone;   Drug: Flurbiprofen;   Drug: Omeprazole;   Drug: Dextromethorphan;   Drug: Midazolam;   Drug: Rosuvastatin;   Drug: Ketoconazole;   Drug: Fluconazole;   Drug: Rifampin
19 Recruiting Pharmacokinetics of Anti-TB Drugs in HIV/TB Co-infected Children in Ghana
Conditions: Tuberculosis;   HIV
20 Completed Drug-Drug Interaction Study With PF-05089771
Condition: Healthy
Intervention: Drug: Pravastatin, midazolam, losartan, omeprazole, caffeine and PF-05089771

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Indicates status has not been verified in more than two years