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38 studies found for:    Puma Biotechnology
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Rank Status Study
1 Completed Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Temsirolimus;   Drug: Neratinib
2 Recruiting A Study of Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in Patients With HER2+ Metastatic Breast Cancer Who Have Received Two or More Prior HER2 Directed Regimens in the Metastatic Setting
Condition: HER2+ Metastatic Breast Cancer (MBC)
Interventions: Drug: neratinib;   Drug: capecitabine;   Drug: lapatinib
3 Recruiting A Study Looking the Incidence and Severity of Diarrhea in Patients With Early-Stage HER2+ Breast Cancer Treated With Neratinib and Loperamide
Condition: Early Stage HER2+ Breast Cancer
Interventions: Drug: Neratinib;   Drug: Loperamide;   Drug: Budesonide;   Drug: Colestipol;   Drug: Bismuth Subsalicylate or Mesalamine
4 Recruiting An Open-label, Phase 2 Study of Neratinib in Patients With Solid Tumors With Somatic Human Epidermal Growth Factor Receptor (EGFR, HER2, HER3) Mutations or EGFR Gene Amplification
Condition: Solid Tumors
Interventions: Drug: Neratinib;   Drug: Paclitaxel;   Drug: Fulvestrant
5 Completed A Single Dose Bioequivalence Study Of Neratinib In Healthy Subjects
Condition: Healthy
Intervention: Drug: Neratinib
6 Completed A Study Of Neratinib (HKI-272) And Capecitabine In Japanese With Solid Tumor
Condition: Advanced Malignant Solid Tumors
Intervention: Drug: Neratinib + Capecitabine
7 Completed Study Evaluating Neratinib In Combination With Vinorelbine In Subjects With Advanced Or Metastatic Solid Tumors
Condition: Advanced Malignant Solid Tumors
Intervention: Drug: treatment with neratinib (HKI-272) + vinorelbine
8 Withdrawn Study Evaluating The Effect Of A High-Fat Meal On The Pharmacokinetics Of Neratinib
Condition: Healthy
Intervention: Drug: Neratinib
9 Active, not recruiting Study Evaluating Neratinib Plus Paclitaxel VS Trastuzumab Plus Paclitaxel In ErbB-2 Positive Advanced Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Neratinib;   Drug: Trastuzumab;   Drug: Paclitaxel
10 Active, not recruiting Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer
Condition: Breast Cancer
Interventions: Drug: neratinib;   Other: placebo
11 Completed Study Evaluating The Potential Effect Of Rifampin On The Pharmacokinetics Of Neratinib
Condition: Healthy Subjects
Intervention: Drug: Neratinib
12 Completed Study Evaluating The Potential Effect Of Multiple Doses Of Neratinib On The Pharmacokinetics Of A Single Dose Of Digoxin
Condition: Healthy
Interventions: Drug: Digoxin;   Drug: Neratinib
13 Completed Study Evaluating Neratinib In Combination With Temsirolimus In Subjects With Solid Tumors
Conditions: Neoplasms;   Malignant Carcinoma
Interventions: Drug: Neratinib;   Drug: Temsirolimus
14 Completed Study Evaluating TwoTablet Formulations of Neratinib (HKI-272)
Condition: Healthy Subjects
Intervention: Drug: neratinib
15 Completed Study Evaluating The PK And Safety Of Neratinib In Healthy Subjects And Subjects With Chronic Liver Disease
Condition: Hepatic Insufficiency
Intervention: Drug: Neratinib (HKI-272)
16 Active, not recruiting Study Evaluating Neratinib Versus Lapatinib Plus Capecitabine For ErbB2 Positive Advanced Breast Cancer
Conditions: Advanced Breast Cancer;   Breast Cancer
Interventions: Drug: Neratinib;   Drug: Lapatinib;   Drug: Capecitabine
17 Completed Study Evaluating Safety And Tolerability, Solid Tumor
Condition: Advanced Malignant Solid Tumors
Intervention: Drug: HKI-272 + Paclitaxel
18 Completed Study Evaluating The Tolerability Of Multiple Doses Of HKI-272
Condition: Healthy Subjects
Intervention: Drug: neratinib
19 Active, not recruiting Study Evaluating The Combination Of Neratinib And Capecitabine In Solid Tumors And Breast Cancer
Condition: Breast Cancer
Interventions: Drug: Neratinib;   Drug: capecitabine
20 Completed Study to Examine the Effect of HKI-272 on Rhythms of the Heart (Cardiac Repolarization)
Condition: Breast Cancer
Interventions: Drug: neratinib;   Other: Placebo;   Drug: Moxifloxacin

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Study has passed its completion date and status has not been verified in more than two years.