Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
57 studies found for:    Periventricular Leukomalacia
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Rank Status Study
1 Recruiting Telerehabilitation of Working Memory in Children With Periventricular Leukomalacia and Bilateral Cerebral Palsy
Condition: Periventricular Leukomalacia
Interventions: Other: Cluster B CogMed: an home-based and computer-based solution to improve working memory deficit;   Other: Cluster A No training. Delay start of CogMed
2 Completed Neuroprotection by Magnesium Sulfate Given to Women at Risk of Very Preterm Birth
Conditions: Preterm Birth;   Periventricular Leukomalacia;   Brain Ischemia;   Intracranial Hemorrhages
Intervention: Drug: magnesium
3 Terminated Probiotics for the Prevention of Premature Birth and Neonatal Related Morbidity
Conditions: Bacterial Vaginosis;   Premature Birth;   Sepsis;   Periventricular Leukomalacia;   Bronchopulmonary Dysplasia
Intervention: Drug: Lactobacillus rhamnosus GR1 and Lactobacillus reuteri RC-14
4 Unknown  Recombinant Erythropoietin for Neuroprotection in Very Preterm Infants
Conditions: Infant, Premature;   Leukomalacia, Periventricular;   Intraventricular Hemorrhage;   Retinopathy of Prematurity
Interventions: Drug: recombinant human erythropoietin (rhEpo);   Drug: Normal saline
5 Completed Premature Infants in Need of Transfusion (PINT)
Condition: Anemia of Prematurity
Intervention: Procedure: Red blood cell transfusion
6 Recruiting Randomized Trial of Maternal Progesterone Therapy
Conditions: Congenital Heart Disease;   Periventricular Leucomalacia;   Brain Development;   Cardiac Surgery;   Neurodevelopmental Disability;   Fetal Neuroprotection
Interventions: Drug: Progesterone;   Drug: Vaginal lubricant
7 Recruiting Inhaled Nitric Oxide and Neuroprotection in Premature Infants
Conditions: Prematurity;   Bronchopulmonary Dysplasia;   Intraventricular Hemorrhage;   Periventricular Leukomalacia
Interventions: Drug: inhaled nitric oxide;   Drug: oxygen
8 Terminated High-Dose Erythropoietin in Extremely Premature Infants to Prevent/Attenuate Brain Injury: A Phase II Study
Conditions: Infant, Premature;   Erythropoietin;   Brain Injury;   Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Neurodevelopmental Outcomes;   Randomized Clinical Trial
Interventions: Drug: Erythropoietin;   Drug: Saline placebo
9 Recruiting Effects of Delayed Cord Clamp and/or Indomethacin on Preterm Infant Brain Injury
Conditions: Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Brain Injury;   Renal Injury
Interventions: Drug: Indomethacin;   Procedure: delay in umbilical cord clamp at birth
10 Recruiting Physiological Disturbances Associated With Neonatal Intraventricular Hemorrhage
Conditions: Intraventricular Hemorrhage;   Autoregulation
Interventions: Other: Hypercapnia;   Other: Normocapnia
11 Completed Antenatal Phenobarbital to Prevent Neonatal Intracranial Hemorrhage
Conditions: Infant, Newborn;   Infant, Low Birth Weight;   Infant, Small for Gestational Age;   Infant, Premature;   Intracranial Hemorrhages
Interventions: Drug: Phenobarbital;   Drug: Saline
12 Completed
Has Results
17OHP for Reduction of Neonatal Morbidity Due to Preterm Birth (PTB) in Twin and Triplet Pregnancies
Condition: Preterm Birth
Interventions: Drug: 17-alpha-hydroxyprogesterone caproate injectable;   Drug: Placebo
13 Recruiting S100B as a Marker of Brain Injury of Preterm Infants
Conditions: Premature Birth;   Brain Injuries;   Leukomalacia Periventricular;   Developmental Disabilities
Intervention:
14 Completed
Has Results
Fluconazole Prophylaxis for the Prevention of Candidiasis in Infants Less Than 750 Grams Birthweight
Condition: Candidiasis
Interventions: Drug: fluconazole;   Drug: placebo
15 Active, not recruiting
Has Results
Surfactant Positive Airway Pressure and Pulse Oximetry Trial
Conditions: Infant, Newborn, Diseases;   Other Preterm Infants;   Infant, Small for Gestational Age;   Premature Birth;   Bronchopulmonary Dysplasia;   Retinopathy of Prematurity
Interventions: Drug: Surfactant;   Device: Continuous Positive Airway Pressure (CPAP);   Drug: Supplemental oxygen with target saturation of 85 to 89%;   Drug: Supplemental oxygen with target saturation of 91 to 95%
16 Completed
Has Results
NIV Strategies for RDS in Preterm Infants. NIV (Non Invasive Ventilation), RDS (Respiratory Distress Syndrome)
Condition: RDS of Prematurity
Interventions: Device: NSIPPV;   Device: BiPAP
17 Completed Umbilical Cord Blood Proteomic Analysis and Neonatal Brain Injury
Conditions: Hypoxia-Ischemia, Brain;   Periventricular Leukomalacia;   Umbilical Cord Blood;   Proteomics
Intervention:
18 Completed Does Erythropoietin Improve Outcome in Very Preterm Infants?
Conditions: Intracranial Hemorrhage;   Periventricular Leukomalacia;   Cerebral Palsy;   Developmental Psychomotor Disorders
Interventions: Drug: Recombinant human Erythropoietin;   Drug: saline
19 Completed Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
Conditions: Cerebral Palsy;   Intraventricular Hemorrhage;   Periventricular Leukomalacia;   Pulmonary Edema;   Abruptio Placentae
Intervention: Drug: magnesium sulfate
20 Terminated
Has Results
Feasibility Study of Aerosolized Surfaxin in the Prevention of Respiratory Distress Syndrome (RDS) in Premature Infants
Condition: Respiratory Distress Syndrome
Intervention: Drug: Aerosolized lucinactant

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Indicates status has not been verified in more than two years