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117 studies found for:    P-glycoprotein
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Rank Status Study
1 Recruiting ABCB1/P-glycoprotein Expression as Biologic Stratification Factor for Patients With Non Metastatic Osteosarcoma
Condition: Osteosarcoma
Interventions: Drug: Mifamurtide arm;   Other: 3 drugs arm
2 Completed Duration of P-glycoprotein Inhibition After Oral Administration of HM30181AK Tablet
Condition: Healthy
Interventions: Drug: HM30181AK 1mg;   Drug: HM30181AK 5mg;   Drug: HM30181AK 15mg;   Drug: HM30181AK 60mg;   Drug: Loperamide 2mg
3 Terminated
Has Results
P-glycoprotein Inhibition as Adjunct Treatment for Medically Refractory Epilepsy.
Condition: Epilepsy
Intervention: Drug: Carvedilol-CR
4 Completed Ontogenesis of the P-Glycoprotein in Human Lymphocytes Influence of HIV and Antiretroviral Therapeutics
Condition: HIV Infections
Intervention:
5 Active, not recruiting Effect of Acute Ethanol Consumption on The Activity of Major Cytochrome P450 Enzymes, NAT2 and P-glycoprotein
Condition: AOD Effects and Consequences
Interventions: Drug: caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses;   Drug: ethanol multiple doses plus caffeine, tolbutamide, omeprazole, dextromethorphan, digoxin, midazolam single doses
6 Completed A Pharmacokinetic Study to Assess the Influence of P-glycoprotein Inhibition and Simultaneous CYP3A4 and P-glycoprotein Induction on E7080 Pharmacokinetics Following Single Dose Oral Administration of 24 mg E7080 to Healthy Volunteers
Conditions: P-glycoprotein;   Healthy Volunteers
Intervention: Drug: Lenvatinib
7 Completed PET Imaging of P-glycoprotein Function Using [11C]dLop
Condition: Healthy
Intervention:
8 Completed P-glycoprotein Function in Brain Diseases
Conditions: Alzheimer Disease;   Parkinson Disease;   Frontotemporal Lobar Degeneration
Intervention:
9 Completed Effect of P-glycoprotein Inhibition on Lenalidomide Pharmacokinetics in Healthy Males
Condition: Healthy
Interventions: Drug: Lenalidomide;   Drug: Quinidine;   Drug: Temsirolimus;   Drug: Diphenhydramine
10 Completed Efavirenz and Ritonavir on Human Brian P-Glycoprotein
Condition: Drug Effects
Interventions: Drug: [11c] desmethyl-loperamide (dLop);   Drug: Ritonavir;   Drug: Efavirenz
11 Completed The Effect of BI 187004 on the Pharmacokinetics of Cytochrome P450 Substrates (Caffeine, Warfarin, Omeprazole, Metoprolol and Midazolam) and a P Glycoprotein Substrate (Digoxin)
Condition: Healthy
Interventions: Drug: midazolam;   Drug: caffeine;   Drug: digoxin;   Drug: warfarin;   Drug: omeprazole;   Drug: BI 187004;   Drug: metoprolol
12 Completed A Phase I Study of Infusional Chemotherapy With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Kidney Neoplasm;   Lymphoma;   Neoplasm Metastasis;   Ovarian Cancer
Intervention: Drug: PSC 833
13 Completed Effects of Tipranavir (With Ritonavir) Capsule and Liquid Formulation on Cytochrome P450 and P-glycoprotein Activity in Healthy Volunteers
Condition: Healthy
Interventions: Drug: Tipranavir capsule;   Drug: Tipranavir solution;   Drug: Ritonavir capsule;   Drug: Caffeine;   Drug: Warfarin sodium;   Drug: Vitamin K;   Drug: Omeprazole;   Drug: Dextromethorphan hydrobromide;   Drug: Midazolam injection;   Drug: Midazolam oral solution;   Drug: Digoxin tablet;   Drug: Digoxin injection
14 Completed Effects of BI 201335 NA on Cytochrome P450 and P-glycoprotein Activity Using a Probe Drug Cocktail in Healthy Volunteers
Condition: Healthy
Interventions: Drug: BI 201335 NA;   Drug: Caffeine;   Drug: Warfarin sodium;   Drug: Vitamin K;   Drug: Omeprazole;   Drug: Dextromethorphan hydrobromide;   Drug: Midazolam HCl solution;   Drug: Midazolam HCl oral syrup;   Drug: Digoxin
15 Terminated (11C)dLop as a Marker of P-Glycoprotein Function in Patients With Gliomas
Conditions: Low Grade Glioma;   Glioblastoma Multiforme;   Anaplastic Astrocytoma;   Anaplastic Oligodendroglioma;   Oligoastrocytoma
Intervention:
16 Completed
Has Results
The Role of P-glycoprotein in Sitagliptin Clinical Pharmacology
Condition: Healthy
Interventions: Drug: Sitagliptin;   Drug: atorvastatin
17 Completed A Pharmacokinetic Study to Assess the Influence of Simultaneous CYP3A4 and P-glycoprotein Inhibition on E7080 Pharmacokinetics Following Single Dose Oral Administration of 5 mg E7080 to Healthy Volunteers
Condition: Healthy Volunteers
Interventions: Drug: ketoconazole-placebo;   Drug: placebo-ketoconazole
18 Completed
Has Results
Paclitaxel and CBT-1(Registered Trademark) to Treat Solid Tumors
Conditions: Cervical;   Ovarian;   Lung;   Breast;   Renal
Interventions: Drug: paclitaxel;   Drug: CBT-1(Registered Trademark);   Radiation: Tc 99m sestamibi
19 Completed A Phase I Study of Infusional Paclitaxel With the P-Glycoprotein Antagonist PSC 833
Conditions: Breast Cancer;   Cancer;   Carcinoma, Renal Cell;   Lymphoma;   Ovarian Cancer
Interventions: Drug: PSC 833;   Drug: paclitaxel
20 Completed Vinorelbine and XR9576 to Treat Cancer
Conditions: Breast Cancer;   Cancer;   Lung Cancer;   Ovarian Cancer
Interventions: Drug: Vinorelbine;   Drug: XR9576

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Study has passed its completion date and status has not been verified in more than two years.