Comment Period Extended to 3/23/2015 for Notice of Proposed Rulemaking (NPRM) for FDAAA 801 and NIH Draft Reporting Policy for NIH-Funded Trials
256 studies found for:    Neurotoxicity
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Rank Status Study
21 Terminated Neurotoxicity in Primary Central Nervous System Lymphoma (PCNSL): An International Observational Study of Cognition in Long Term Survivors
Condition: Primary Central Nervous System Lymphoma (PCNSL)
Intervention:
22 Completed Combination Chemotherapy in Treating Younger Patients With Hodgkin Lymphoma
Conditions: Lymphoma;   Neurotoxicity
Interventions: Drug: cyclophosphamide;   Drug: doxorubicin hydrochloride;   Drug: etoposide;   Drug: prednisolone;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Radiation: radiation therapy
23 Completed Amifostine in Treating Peripheral Neuropathy Caused by Paclitaxel in Patients With Solid Tumors
Conditions: Breast Cancer;   Lung Cancer;   Neurotoxicity;   Ovarian Cancer;   Prostate Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Intervention: Drug: Amifostine
24 Completed S0715: Acetyl-L-Carnitine in Preventing Neuropathy in Women With Stage I, Stage II, or Stage IIIA Breast Cancer Undergoing Chemotherapy
Conditions: Breast Cancer;   Chemotherapeutic Agent Toxicity;   Fatigue;   Neuropathy;   Neurotoxicity
Interventions: Dietary Supplement: acetyl-L-carnitine hydrochloride;   Other: placebo
25 Enrolling by invitation Prospective Observational Pilot-study for the Evaluation of the Nephro- an Neurotoxicity in the Anti-infectious Therapy With Inhalative Colistin Therapy for Patients With Ventilator-associated Pneumonia (VAP)
Condition: Infection Resistant to Multiple Drugs
Intervention: Other: TDM, Monitoring of Neuro-and Nephropathology
26 Withdrawn Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL
Conditions: Brain and Central Nervous System Tumors;   Lymphoma;   Neurotoxicity
Interventions: Biological: Rituximab;   Drug: Cytarabine;   Drug: Methotrexate;   Drug: Motexafin gadolinium;   Drug: Procarbazine hydrochloride;   Drug: Vincristine sulfate;   Radiation: Radiation therapy
27 Active, not recruiting Brain Function in Young Patients Receiving Methotrexate for Acute Lymphoblastic Leukemia
Conditions: B-cell Childhood Acute Lymphoblastic Leukemia;   Cognitive/Functional Effects;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment;   T-cell Childhood Acute Lymphoblastic Leukemia;   Untreated Childhood Acute Lymphoblastic Leukemia
Interventions: Procedure: cognitive assessment;   Procedure: psychosocial assessment and care;   Procedure: diffusion tensor imaging;   Other: laboratory biomarker analysis;   Other: pharmacological study
28 Recruiting Advanced Neuroimaging Evaluation of the Central Nervous System Biological Changes Associated With Efavirenz Therapy Switch to an Raltegravir-based Regimen
Conditions: HIV;   HIV-associated Neurocognitive Disorder;   Neurotoxicity
Intervention: Drug: switch efavirenz (EFV) to raltegravir (RAL)
29 Unknown  Duloxetine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Conditions: Neurotoxicity Syndromes;   Pain;   Peripheral Neuropathy;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: duloxetine hydrochloride;   Other: placebo
30 Completed Investigation of Serotonin Neurotransmission in MDMA Users Using Combinated Dexfenfluramine Challenge and PET Imaging
Conditions: Amphetamine-Related Disorders;   Amphetamine Abuse
Intervention: Drug: dexfenfluramine
31 Active, not recruiting (1)H-Nuclear Magnetic Resonance Spectroscopic Imaging of the Brain in Patients Who Receive Neurotoxic Therapy
Conditions: Brain Cancer;   Brain Neoplasms
Intervention:
32 Withdrawn A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis of Oxaliplatin
Conditions: Colorectal Carcinoma;   Neoplasms, Colorectal;   Colorectal Cancer;   Colorectal Tumors;   Metastasis
Intervention: Dietary Supplement: Glutamine
33 Unknown  N-AcetylCysteine vs. Placebo to Prevent Neurotoxicity Induced by Platinum Containing Chemotherapy
Conditions: Carcinoma, Non-Small-Cell Lung;   Carcinoma, Small Cell Lung;   Mesothelioma
Interventions: Drug: N-Acetylcysteine;   Drug: Placebo
34 Unknown  Glutathione in Preventing Peripheral Neuropathy Caused by Paclitaxel and Carboplatin in Patients With Ovarian Cancer, Fallopian Tube Cancer, and/or Primary Peritoneal Cancer
Conditions: Chemotherapeutic Agent Toxicity;   Fallopian Tube Cancer;   Neurotoxicity;   Ovarian Cancer;   Pain;   Peripheral Neuropathy;   Primary Peritoneal Cavity Cancer
Interventions: Drug: carboplatin;   Drug: glutathione;   Drug: paclitaxel;   Other: placebo
35 Unknown  Acute Pain Caused by Paclitaxel in Patients With Cancer
Conditions: Chemotherapeutic Agent Toxicity;   Neurotoxicity;   Pain;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: paclitaxel;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Other: questionnaire administration;   Procedure: assessment of therapy complications
36 Unknown  Pelvic Radiation Therapy or Vaginal Implant Radiation Therapy, Paclitaxel, and Carboplatin in Treating Patients With High-Risk Stage I or Stage II Endometrial Cancer
Conditions: Endometrial Cancer;   Fatigue;   Neurotoxicity
Interventions: Drug: carboplatin;   Drug: paclitaxel;   Radiation: brachytherapy;   Radiation: intensity-modulated radiation therapy;   Radiation: radiation therapy
37 Completed Glutamine in Treating Neuropathy Caused by Vincristine in Young Patients With Lymphoma, Leukemia, or Solid Tumors
Conditions: Kidney Cancer;   Leukemia;   Lymphoma;   Neurotoxicity;   Peripheral Neuropathy;   Sarcoma
Interventions: Drug: Glutamine;   Other: Placebo
38 Active, not recruiting
Has Results
Donepezil in Treating Young Patients With Primary Brain Tumors Previously Treated With Radiation Therapy to the Brain
Conditions: Brain and Central Nervous System Tumors;   Cognitive/Functional Effects;   Long-term Effects Secondary to Cancer Therapy in Children;   Neurotoxicity;   Psychosocial Effects of Cancer and Its Treatment;   Radiation Toxicity
Intervention: Drug: Donepezil
39 Unknown  Lamotrigine in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Conditions: Neurotoxicity;   Pain;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: lamotrigine;   Procedure: quality-of-life assessment
40 Active, not recruiting Topical Amitriptyline and Ketamine Cream in Treating Peripheral Neuropathy Caused by Chemotherapy in Patients With Cancer
Conditions: Neurotoxicity;   Pain;   Peripheral Neuropathy;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: ketamine/amitriptyline NP-H cream;   Other: placebo

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Indicates status has not been verified in more than two years