1 |
NCT02868593 |
Recruiting |
Etiology of Orphan Community-based Meningitis and Meningo-encephalitis. |
- Community-based Meningitis
- Meningo-encephalitis
|
|
Interventional |
Not Applicable |
- Assistance Publique Hopitaux De Marseille
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Percentage of patients with established etiological diagnosis of community based meningitis or meningo-encephalitis
|
1800 |
All |
18 Years and older (Adult, Senior) |
NCT02868593 |
2013-47 2013-A01538-37 |
MENINGITE |
January 2014 |
January 2017 |
June 2017 |
August 16, 2016 |
August 16, 2016 |
|
- Assistance Publique Hopitaux de Marseille
Marseille, France
|
2 |
NCT02328469 |
Recruiting |
Aseptic Meningoencephalitis in Slovenia |
|
- Drug: symptomatic therapy
- Drug: Ceftriaxone or Doxycycline
- Other: questionnaire
- Drug: Acyclovir
|
Observational |
|
- University Medical Centre Ljubljana
- Slovenian Research Agency
- University of Ljubljana School of Medicine, Slovenia
- Harvard University
|
Other |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Changes in selected clinical parameters in patients with acute aseptic meningitis/meningoencephalitis
- Changes in selected laboratory parameters in patients with acute aseptic meningitis/meningoencephalitis
- Changes in selected microbiologic parameters in patients with acute aseptic meningitis/meningoencephalitis
|
800 |
All |
18 Years and older (Adult, Senior) |
NCT02328469 |
mgt-0614 |
|
June 2014 |
June 2017 |
June 2017 |
December 31, 2014 |
May 12, 2016 |
|
- Department of Infectious Diseases, University Medical Center Ljubljana, Ljubljana, Slovenia
Ljubljana, Slovenia - UMC Ljubljana, Department of Infectious Diseases
Ljubljana, Slovenia
|
3 |
NCT02910037 |
Completed |
Precision Diagnosis of Acute Infectious Diseases; Neuroinflammatory Cohort |
|
- Device: mNGS for pathogen detection
|
Interventional |
Not Applicable |
- University of California, San Francisco
- California Initiative to Advance Precision Medicine
- Sandler Foundation
- (and 11 more...)
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Impact on clinical reasoning and management
- Cost of care for patients hospitalized for encephalitis/meningitis
- Clinical outcomes: time to diagnosis
- (and 3 more...)
|
204 |
All |
up to 110 Years (Child, Adult, Senior) |
NCT02910037 |
P0509948 |
PDAID |
June 1, 2016 |
July 31, 2017 |
July 31, 2017 |
September 21, 2016 |
April 13, 2018 |
|
- University of California, Davis Medical Center
Davis, California, United States - Children's Hospital Los Angeles
Los Angeles, California, United States - University of California, Los Angeles Medical Center
Los Angeles, California, United States - (and 4 more...)
|
4 |
NCT02624453 |
Active, not recruiting |
Pre-Antiretroviral Therapy (ART) Cryptococcal Antigen Screening in AIDS |
|
- Drug: Fluconazole
- Drug: Antiretroviral therapy
|
Interventional |
Not Applicable |
- French National Institute for Health and Medical Research-French National Agency for Research on AIDS and Viral Hepatitis (Inserm-ANRS)
- Yaounde Central Hospital
- St George's, University of London
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Prevalence of cryptococcal antigenaemia and antigenuria
- Baseline prevalence of laboratory confirmed Cryptococcal Meningitis
|
186 |
All |
18 Years and older (Adult, Senior) |
NCT02624453 |
ANRS 12312 PreCASA |
PreCASA |
July 2015 |
March 2018 |
March 2018 |
December 8, 2015 |
March 15, 2018 |
|
- Day Hospital of the Yaounde Central Hospital
Yaounde, Central Region, Cameroon
|
5 |
NCT03226379 |
Recruiting |
Driving Reduced AIDS-associated Meningo-encephalitis Mortality |
- AIDS-Related Opportunistic Infections
- Meningoencephalitis
- Cryptococcal Meningitis
|
|
Observational |
|
- St George's, University of London
- European and Developing Countries Clinical Trials Partnership (EDCTP)
- National Institute for Medical Research, Tanzania
- (and 4 more...)
|
Other / Industry |
- Observational Model: Other
- Time Perspective: Other
|
- All-cause mortality
- Time to lumbar puncture (LP) or other appropriate diagnostic investigation.
- Time to meningo-encephalitis treatment
- (and 4 more...)
|
450 |
All |
18 Years and older (Adult, Senior) |
NCT03226379 |
16.0091 |
DREAMM |
April 23, 2016 |
October 2019 |
April 2020 |
July 21, 2017 |
July 21, 2017 |
|
- Kamuzu Central Hospital
Lilongwe, Malawi - Amana Hospital
Dar es Salaam, Tanzania
|
6 |
NCT01694524 |
Completed |
Nervous System Infections Among Patients With Febrile Seizure |
- Seizure
- Febrile Seizure
- Meningitis
- Encephalitis
|
|
Observational |
|
- Hôpital Armand Trousseau
- Robert Debré Hospital
- Hôpital Jean Verdier
- (and 4 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Retrospective
|
- Bacterial meningitis
- Herpes simplex virus meningitis/encephalitis
- emergent intracranial processus
|
1200 |
All |
3 Months to 5 Years (Child) |
NCT01694524 |
febrile seizure and infection |
|
June 2013 |
March 2014 |
March 2014 |
September 27, 2012 |
May 20, 2014 |
|
- Hopital Jean Verdier
Bondy, France - Centre hospitalier intercommunal de creteil
Creteil, France - Centre hospitalier Lagny-Marne la Vallée
Lagny-Sur-Marne, France - (and 4 more...)
|
7 |
NCT02463942 |
Recruiting |
Tick-borne Encephalitis and Positive Borrelial Antibodies |
|
- Drug: Doxycycline
- Drug: Symptomatic therapy
- Other: Questionnaire
|
Interventional |
Not Applicable |
- University Medical Centre Ljubljana
- University of Ljubljana School of Medicine, Slovenia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Objective manifestations of Lyme borreliosis
- Frequency of nonspecific symptoms such as headache, fatigue, arthralgia, myalgia
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02463942 |
TBE-LB2014 |
TBE-LB2014 |
September 2014 |
September 2018 |
September 2019 |
June 4, 2015 |
May 12, 2016 |
|
- UMC Ljubljana, Department of Infectious Diseases
Ljubljana, Slovenia
|
8 |
NCT00774631 |
Terminated |
IHPOTOTAM : Induced HyPOthermia TO Treat Adult Meningitis |
|
- Procedure: Mild induced hypothermia (32-34°C)
- Procedure: local recommendations and guidelines
|
Interventional |
Phase 4 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Proportion of patients with unfavorable outcome (defined as score on Glasgow outcome Scale < 5) at 3 months after admission.
- Mortality (assessed on day 14 after admission, day 28, total in-hospital mortality, and at 3 and 6 months)
- ICU length of stay
- (and 7 more...)
|
98 |
All |
18 Years and older (Adult, Senior) |
NCT00774631 |
P 060217 AOM 06 038 |
IHPOTOTAM |
March 2009 |
February 2012 |
July 2012 |
October 17, 2008 |
September 17, 2012 |
|
- Hopital Bichat Claude Bernard
Paris, France
|
9 |
NCT01466387 |
Completed Has Results |
A Phase 3b, Randomized, Open-Label Study to Evaluate the Safety and Immunogenicity of Select Travel Vaccines When Administered Concomitantly With MenACWY in Adults |
- Meningococcal Disease
- Meningococcal Meningitis
- Typhoid
- (and 3 more...)
|
- Biological: Typhoid Vi Polysaccharide Vaccine
- Biological: Yellow Fever Vaccine
- Biological: Japanese Encephalitis Vaccine
- (and 2 more...)
|
Interventional |
Phase 3 |
- Novartis
- Novartis Vaccines
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Geometric Mean Anti-typhoid Vi Antibody Concentrations
- Geometric Mean Anti-Yellow Fever Antibody Titer
- Geometric Mean Anti-Japanese Encephalitis Neutralizing Antibody Titers
- (and 11 more...)
|
552 |
All |
18 Years to 60 Years (Adult) |
NCT01466387 |
V59_38 2011-000475-14 |
|
November 2011 |
April 2012 |
April 2012 |
November 8, 2011 |
March 11, 2014 |
March 11, 2014 |
- Centrum ockovani a cestovni mediciny (Vaccination and Travel Medicine Centre) Poliklinika II
Bratri Stefanu 895, Hradec Kralove, Czech Republic - Berliner Centrum Fur Reise und Tropenmedizin
Jaegerstrasse 67-69, Berlin, Germany - Bernhard Nocht Strasse 74, Hamburg, Germany
- (and 2 more...)
|
10 |
NCT03418441 |
Recruiting |
Central Nervous System Infections in Denmark |
- Central Nervous System Infections
- Bacterial Meningitis
- Viral Meningitis
- (and 9 more...)
|
- Other: Community-acquired CNS infections
|
Observational |
|
- Aalborg Universitetshospital
- Danish Study Group of Infections of the Brain
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence
- Glasgow Outcome Scale score
- Glasgow Outcome Scale score for viral meningitis
- (and 5 more...)
|
1400 |
All |
18 Years and older (Adult, Senior) |
NCT03418441 |
DASGIB |
DASGIB |
January 1, 2015 |
January 1, 2025 |
January 1, 2025 |
February 1, 2018 |
February 6, 2018 |
|
- Department of Infectious Diseases, Aalborg University Hospital
Aalborg, Denmark - Department of Infectious Diseases, Aarhus University Hospital Skejby
Aarhus, Denmark - Department of Infectious Diseases, Rigshospitalet
Copenhagen, Denmark - (and 4 more...)
|
11 |
NCT02017665 |
Active, not recruiting |
Singapore Neurologic Infections Program |
- Central Nervous System Infections
|
|
Observational |
|
- Singapore General Hospital
- Tan Tock Seng Hospital
- Duke-NUS Graduate Medical School
- (and 3 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Incidence rate of the various infective etiologies causing CNS infections in Singapore
- Clinical features of patients with CNS infections in Singapore
- Clinical characteristics of patients diagnosed with CNS infections: .
- (and 2 more...)
|
400 |
All |
21 Years to 100 Years (Adult, Senior) |
NCT02017665 |
2013/374/E |
SNIP |
October 2013 |
December 2017 |
December 2017 |
December 23, 2013 |
April 27, 2017 |
|
- Singapore General Hospital
Singapore, Singapore
|
12 |
NCT03206541 |
Recruiting |
Neurologic Manifestations of the Arbovirus Infection in Colombia |
- Encephalitis
- Myelitis
- Guillain-Barre Syndrome
- (and 5 more...)
|
|
Observational |
|
- Johns Hopkins University
- Universidad del Valle, Colombia
- ZikaPLAN
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Neurological outcomes in arbovirus infections
- Viral genotype
- Immune response
|
150 |
All |
8 Years and older (Child, Adult, Senior) |
NCT03206541 |
IRB00093149 |
|
January 1, 2016 |
December 2018 |
December 2018 |
July 2, 2017 |
July 2, 2017 |
|
- Clinica Leon XIII
Medellín, Antioquia, Colombia - Neuroclinica
Medellín, Antioquia, Colombia - Clinica La Misericordia Internacional
Barranquilla, Atlantico, Colombia - (and 5 more...)
|
13 |
NCT02979951 |
Recruiting |
Fosfomycin i.v. for Treatment of Severely Infected Patients |
- Bacterial Infections
- Bone Diseases, Infectious
- Osteomyelitis
- (and 13 more...)
|
|
Observational |
|
- Infectopharm Arzneimittel GmbH
- INPADS GmbH
- Dr. Oestreich + Partner GmbH
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Percentage of patients with clinical success as defined as clinical cure or clinical improvement
- Microbiological cure
- Clinical success as defined as clinical cure or clinical improvement
- (and 11 more...)
|
1000 |
All |
18 Years and older (Adult, Senior) |
NCT02979951 |
FORTRESS |
FORTRESS |
December 2016 |
June 2020 |
June 2020 |
December 2, 2016 |
July 28, 2017 |
|
- Universitätsmedizin Charité
Berlin, Germany - Vivantes Kliniken Neukölln
Berlin, Germany - Universitäts Düsseldorf; Klinik für Anästhesiologie
Dusseldorf, Germany - (and 7 more...)
|
14 |
NCT02207647 |
Active, not recruiting |
Prevalence of Pathogens in Cerebrospinal Fluid Obtained From Emergency Department Patients |
- Meningoencephalitis
- Other Syndromes Requiring Lumbar Puncture in Emergency Department
|
|
Observational |
|
- Olive View-UCLA Education & Research Institute
- Centers for Disease Control and Prevention
|
Other / U.S. Fed |
- Observational Model: Ecologic or Community
- Time Perspective: Prospective
|
|
1000 |
All |
3 Months and older (Child, Adult, Senior) |
NCT02207647 |
12H-770352 U01CK000176 |
|
April 2014 |
July 2016 |
July 2018 |
August 4, 2014 |
April 10, 2018 |
|
- Olive View-UCLA Medical Center
Sylmar, California, United States
|
15 |
NCT00172393 |
Unknown † |
Long Term Outcomes of EV71 CNS Infection |
- Central Nervous System Infection
|
|
Observational |
|
- National Taiwan University Hospital
|
Other |
- Observational Model: Defined Population
- Observational Model: Natural History
- Time Perspective: Cross-Sectional
- Time Perspective: Retrospective/Prospective
|
|
150 |
All |
1 Month to 18 Years (Child, Adult) |
NCT00172393 |
9311700446 |
|
January 2003 |
|
May 2005 |
September 15, 2005 |
October 4, 2006 |
|
- National Taiwan University Hsopital
Taipei, Taiwan
|
16 |
NCT00769834 |
Withdrawn |
Disc Edema in Patients With Chronic Kidney Disease |
|
|
Observational |
|
- University of Mississippi Medical Center
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- disc edema
- ophthalmoscopic diagnosis
- neurologic diagnosis
|
0 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT00769834 |
2008-0019 |
|
January 2010 |
December 2010 |
April 2011 |
October 9, 2008 |
February 28, 2018 |
|
- University of Mississippi Medical Center
Jackson, Mississippi, United States
|
17 |
NCT00492557 |
Completed Has Results |
Study Evaluating Safety and Immunogenicity of 13-Valent Pneumococcal Conjugate Vaccine With Influenza Vaccine in Adults |
|
- Biological: 13-valent pneumococcal conjugate vaccine
- Biological: 13vPnC + TIV
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Prevention
|
- TIV Comparisons: Percentage of Participants Achieving at Least a 4-fold Increase in the Titer of the Standard Hemagglutination Inhibition Assay (HAI)
- 13vPnC Comparisons: Serotype-specific Pneumococcal Immunoglobulin G (IgG) Geometric Mean Concentration (GMC)
|
1185 |
All |
65 Years and older (Adult, Senior) |
NCT00492557 |
6115A1-3008 |
|
September 2007 |
February 2008 |
February 2008 |
June 27, 2007 |
February 17, 2012 |
February 17, 2012 |
|
18 |
NCT02062281 |
Completed |
Study of Evaluating Safety and Immunogenicity of 23-Valent Pneumococcal Polysaccharide Vaccine With Influenza Vaccine in Children and Adults |
- Pneumococcal Infection
- Influenza
|
- Biological: 23-valent pneumococcal polysaccharide vaccine
- Biological: trivalent influenza vaccine
- Biological: 23vPPV+TIV
|
Interventional |
Phase 4 |
- Jiangsu Province Centers for Disease Control and Prevention
- Chengdu Institute of Biological Products Co.,Ltd.
- Shanghai Institute Of Biological Products
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Prevention
|
- Immunogenicity of 23vPPV
- Immunogenicity of TIV
- adverse events following the immunization (AEFI)
|
2225 |
All |
3 Years to 65 Years (Child, Adult) |
NCT02062281 |
JSEPI-002 |
|
November 2013 |
December 2013 |
January 2014 |
February 13, 2014 |
February 13, 2014 |
|
- Yangzhong Center for Disease Control and Prevention
Zhenjiang, Jiangsu, China
|
19 |
NCT02906631 |
Recruiting |
Epidemiology and Prognosis of Encephalitis in Intensive Care |
|
|
Observational |
|
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Neurological status on the modified Rankin scale
- Biological data within 7 days following onset of altered mental status
- State of consciousness defined by the Glasgow Coma Scale within 7 days following onset of altered mental status
- (and 21 more...)
|
300 |
All |
18 Years and older (Adult, Senior) |
NCT02906631 |
AOR 15096 |
ENCEPHALITICA |
October 27, 2017 |
July 2019 |
December 2019 |
September 20, 2016 |
November 6, 2017 |
|
- Hôpital Bichat-Claude Bernard
Paris, France
|
20 |
NCT00927953 |
Terminated Has Results |
Treatment of West Nile Virus With MGAWN1 |
- West Nile Neuroinvasive Disease
- West Nile Virus Infection
- Encephalitis
- (and 3 more...)
|
- Biological: MGAWN1
- Biological: Placebo - normal saline
|
Interventional |
Phase 2 |
- MacroGenics
- National Institute of Allergy and Infectious Diseases (NIAID)
|
Industry / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Number of West Nile Neuroinvasive Disease (WNND) Participants Who Show Improvement in the Modified Rankin Scale (MRS) (>=1 Improvement in Score)
- The Number of Participants Who Had At Least 1 Treatment-Related Adverse Event
- The Number of Participants With a Favorable Neurologic Outcome
- (and 2 more...)
|
13 |
All |
18 Years and older (Adult, Senior) |
NCT00927953 |
CP-MGAWN1-02 |
PARADIGM |
May 2009 |
February 2011 |
May 2011 |
June 25, 2009 |
November 7, 2012 |
November 7, 2012 |
|
21 |
NCT03226119 |
Active, not recruiting |
MP Diagnostics HTLV Blot 2.4 Post-Market Clinical Study |
- HTLV-I Infections
- HTLV-II Infections
- Human T-lymphotropic Virus 1
- (and 3 more...)
|
- Diagnostic Test: MP Diagnostics HTLV Blot 2.4
|
Interventional |
Phase 4 |
- MP Biomedicals, LLC
- MP Biomedicals Asia Pacific Pte. Ltd.
|
Industry / Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Diagnostic
|
- To demonstrate ≥95% agreement of HTLV Blot 2.4 results with the Reference Core Laboratory HTLV Algorithm in 100 Neurological Disorder Specimens
- To demonstrate HTLV Blot 2.4 sensitivity of ≥97.5% in 50 HTLV Known Positive Specimens
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT03226119 |
MP-EIA-HTLV-002B |
|
January 15, 2018 |
May 15, 2018 |
May 15, 2018 |
July 21, 2017 |
March 29, 2018 |
|
- LABS, Inc.
Philadelphia, Pennsylvania, United States - Qualtex Laboratories
San Antonio, Texas, United States - Eastern Virginia Medical School (EVMS)
Norfolk, Virginia, United States
|
22 |
NCT03112031 |
Recruiting |
Treatment With Tamoxifen in Cryptococcal Meningitis |
- Meningitis Streptococcal
- Hiv
- Meningitis
- Meningoencephalitis
|
- Drug: Tamoxifen
- Drug: Amphotericin B
- Drug: Fluconazole
|
Interventional |
Phase 2 |
- Oxford University Clinical Research Unit, Vietnam
- Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam
- Cho Ray Hospital, Ho Chi Minh City, Vietnam
- (and 3 more...)
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Early Fungicidal Activity (EFA), i.e. the rate of clearance of yeast from cerebrospinal fluid
- Survival until 10 weeks after randomization
- Disability at 10 weeks
- (and 9 more...)
|
50 |
All |
18 Years and older (Adult, Senior) |
NCT03112031 |
28CN |
|
October 10, 2017 |
August 2019 |
December 2020 |
April 13, 2017 |
April 11, 2018 |
|
- Cho Ray Hospital
Ho Chi Minh City, Vietnam - Hospital for Tropical Diseases
Ho Chi Minh City, Vietnam - Oxford University Clinical Research Unit
Ho Chi Minh City, Vietnam
|
23 |
NCT00091845 |
Terminated |
An Exploratory Study of AVI-4020 in Patients With Possible Acute Neuroinvasive West Nile Virus (WNV) Disease |
|
|
Interventional |
Phase 1 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Safety and tolerability assessments will be based on evaluations of treatment emergent adverse events (TEAE), serious adverse events (SAE), serial clinical examinations, and serial conventional laboratory tests.
- A secondary endpoint is the potential effectiveness of AVI-4020 Injection based on the neurological status measured by a combination of the NIH Stroke Scale and the Glasgow Coma Score (GCS).
|
50 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT00091845 |
AVI-4020-14 |
|
November 2004 |
|
November 2004 |
September 21, 2004 |
July 8, 2009 |
|
|
24 |
NCT02924220 |
Enrolling by invitation |
Genetic Susceptibility and Biomarkers in Listeriosis |
|
|
Observational |
|
- Institut Pasteur
- Icahn School of Medicine at Mount Sinai
|
Industry / Other |
- Observational Model: Case-Control
- Time Perspective: Retrospective
|
- Characterisation of genetic susceptibility markers for infection as a whole and for each form and/or for the severity of infection
- Biomarkers identification in serum and plasma of patients and controls
|
1274 |
All |
Child, Adult, Senior |
NCT02924220 |
2016-038 ID-RCB number : 2016-A00650-51 |
MONALISAGENBIO |
February 16, 2017 |
September 2019 |
September 2019 |
October 5, 2016 |
August 2, 2017 |
|
- Institut Pasteur, Unité de Biologie des Infections
Paris, France
|