127 studies found for:    Immunodeficiency NOT AIDS | Open Studies
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Rank Status Study
21 Recruiting Sequential Cadaveric Lung and Bone Marrow Transplant for Immune Deficiency Diseases
Conditions: Severe Combined Immunodeficiency (SCID);   Immunodeficiency With Predominant T-cell Defect, Unspecified;   Severe Chronic Neutropenia;   Chronic Granulomatous Disease (CGD);   Hyper IgE Syndromes;   Hyper IgM Deficiencies;   Wiskott-Aldrich Syndrome;   Mendelian Susceptibility to Mycobacterial Disease;   Common Variable Immune Deficiency (CVID)
Intervention: Biological: CD3/CD19 negative allogeneic hematopoietic stem cells
22 Recruiting Gene Transfer for Severe Combined Immunodeficiency, X-linked (SCID-X1) Using a Self-inactivating (SIN) Gammaretroviral Vector
Condition: Severe Combined Immunodeficiency
Intervention: Biological: Gene transfer
23 Recruiting Sirolimus Prophylaxis for aGVHD in TME SCID
Conditions: Severe Combined Immunodeficiency;   Transplacental Maternal Engraftment;   Stem Cell Transplant
Intervention: Drug: Sirolimus
24 Recruiting EZN-2279 in Patients With ADA-SCID
Conditions: ADA-SCID;   Adenosine Deaminase Deficiency;   Severe Combined Immunodeficiency
Intervention: Biological: EZN-2279
25 Available Expanded Access Protocol Thymus Transplantation
Conditions: Poor Thymic Function;   Immunodeficiency;   Athymia;   Immunoreconstitution;   Thymus Transplantation;   Low T Cell Numbers
Interventions: Biological: Thymus Transplantation;   Procedure: Blood Draw;   Drug: Rabbit Anti-Thymocyte Globulin and Cyclosporine or Tacrolimus
26 Unknown  Bronchial Inflammation in Patients With Severe Immune Deficiency Under Immunoglobulin Treatment
Condition: Immune Deficiency
Intervention:
27 Unknown  Evaluation of Efficacy and Tolerability of Hizentra®
Condition: Primary Immunodeficiency Disorders
Intervention: Drug: Hizentra
28 Recruiting TCR Alpha/Beta Depletion for HSCT From Haploidentical and Unrelated Donors in the Treatment of PID
Conditions: Primary Immune Deficiency Disorder;   Hematopoietic Stem Cell Transplantation
Intervention: Other: Biological: TCR alfa beta T cell depletion
29 Recruiting Reduced Intensity Conditioning in Patients Aged ≤35 With Non-Malignant Disorders Undergoing UCBT, BMT, or PBSCT
Conditions: Primary Immunodeficiency Syndromes;   Congenital Bone Marrow Failure Syndromes;   Inherited Metabolic Disorders (IMD);   Hereditary Anemias;   Patients With Sickle Disease Presenting Specific Symptoms
Interventions: Drug: Hydroxyurea;   Drug: Alemtuzumab;   Drug: Fludarabine;   Drug: Melphalan;   Drug: Thiotepa
30 Recruiting Evaluate Bacteriophage as a Useful Immunogen in Patients With Primary Immune Deficiency Diseases (PIDD)
Condition: Primary Immune Deficiency Diseases
Intervention: Biological: Bacteriophage OX174
31 Recruiting Immune Disorder HSCT Protocol
Conditions: Immune Deficiency Disorders:;   Severe Combined Immunodeficiency;   Chronic Granulomatous Disease;   X-linked Agammaglobulinemia;   Wiskott-Aldrich Syndrome;   Hyper-IgM;   DiGeorge Syndrome;   Chediak-Higashi Syndrome;   Common Variable Immune Deficiency;   Immune Dysregulatory Disorder:;   Hemophagocytic Lymphohistiocytosis;   IPEX;   Autoimmune Lymphoproliferative Syndrome;   X-linked Lymphoproliferative Syndrome
Intervention: Drug: Transplant preparative regimen of alemtuzumab, fludarabine, thiotepa, and melphalan
32 Recruiting Octagam 5% Versus Comparator Post Marketing Trial
Condition: Primary Immune Deficiency Disorder
Interventions: Biological: Octagam 5%;   Biological: Other marketed IVIG product
33 Recruiting Reduced Intensity Conditioning for Hemophagocytic Syndromes or Selected Primary Immune Deficiencies (BMT CTN 1204)
Conditions: Hemophagocytic Lymphohistiocytosis;   Chronic Active Epstein-Barr Virus Infection;   Chronic Granulomatous Disease;   HIGM-1;   Leukocyte Adhesion Deficiency;   IPEX
Intervention: Biological: Hematopoietic Stem Cell Transplant
34 Recruiting Screening Protocol for Genetic Diseases of Lymphocyte Homeostasis and Programmed Cell Death
Condition: Primary Immune Deficiency
Intervention:
35 Not yet recruiting Study of Efficacy of CDZ173 in Patients With APDS/PASLI
Condition: Activated PI3Kdelta Syndrome (APDS); p110delta-activating Mutation Causing Senescent T Cells, Lymphadenopathy and Immunodeficiency (PASLI)
Intervention: Drug: CDZ173
36 Recruiting Allogeneic Hematopoietic Stem Cell Transplant for GATA2 Mutations
Conditions: GATA2;   Immunodeficiency;   MDS
Interventions: Procedure: Allogeneic HSC;   Drug: Busulfan Test dose;   Drug: Fludarabine(Fludara, Berlex Laboratories);   Drug: Busulfan (Busulfex);   Drug: Cyclophosphamide(CTX, Cytoxan);   Procedure: Total Body Irradiation (TBI);   Drug: Equine Anti-Thymocyte Globulin
37 Recruiting Natural History of Bronchiectasis
Conditions: Bronchiectasis;   Cystic Fibrosis;   Autoimmune Disease;   Common Variable Immunodeficiency
Intervention:
38 Recruiting Reduced Intensity Conditioning Using CD3+/CD19+ Depletion for Non Malignant Transplantable Diseases
Conditions: Bone Marrow Failure Syndromes;   Immunodeficiencies;   Immune Dysregulation Syndromes
Intervention: Device: CD3+/CD19+ delpletion using CliniMACs device follwing reduced intensity conditioning
39 Recruiting Study of Octanorm Subcutaneous IG in Patients With PID
Condition: Primary Immune Deficiency Disorder
Intervention: Biological: octanorm 16.5%
40 Not yet recruiting Lentiviral Gene Therapy for Adenosine Deaminase (ADA) Deficiency
Conditions: Adenosine Deaminase Deficiency;   Severe Combined Immunodeficiencies (SCID)
Intervention: Genetic: EF1αS-ADA lentiviral vector transduced patient Cd34+ cells

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Indicates status has not been verified in more than two years