| 1 |
NCT03503734 |
Completed
New |
Integrated Care for Migraine and Chronic Tension-type Headaches |
|
- Behavioral: Integrated headache care
|
Observational |
|
- Universität Duisburg-Essen
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Headache frequency
- Pain intensity
- Pain bothersomeness
- (and 6 more...)
|
158 |
All |
18 Years and older (Adult, Senior) |
NCT03503734 |
11-4749 |
IV |
August 18, 2011 |
July 30, 2013 |
January 30, 2014 |
April 20, 2018 |
April 20, 2018 |
|
- Department of Internal and Integrative Medicine, Kliniken Essen-Mitte, Faculty of Medicine, University of Duisburg-Essen
Essen, NRW, Germany
|
| 2 |
NCT03439722 |
Completed |
Sleep in Cluster Headache: Sleep Parameters in- and Outside a Cluster Bout |
|
|
Observational |
|
- Danish Headache Center
- Danish Headache Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Compare the macrostructure of sleep in episodic cluster headache patients in bout with in remission
- Compare the macrostructure of sleep in episodic cluster headache patients with healthy controls
- The presence of any sleep disorders in patients and controls
|
66 |
All |
18 Years to 65 Years (Adult) |
NCT03439722 |
H-7-2014-020 Sleep study |
|
January 2016 |
January 2018 |
January 2018 |
February 20, 2018 |
February 20, 2018 |
|
- Danish Headache Center, Dept. of Neurology, Rigshospitalet -Glostrup
Glostrup, Denmark
|
| 3 |
NCT02853487 |
Completed |
Circadian Rhythm and Attack-timing in Episodic Cluster Headache Patients in- and Outside of Bout: an Actigraphic Study |
|
- Device: Actigraphy
- Other: Diary
|
Observational |
|
- Danish Headache Center
- Danish Headache Center
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Circadian rhythm
- Attack occurence
- Physical activity before and during an attack
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT02853487 |
H-7-2014-020 |
|
July 2016 |
February 1, 2018 |
February 1, 2018 |
August 3, 2016 |
February 13, 2018 |
|
- Danish Headache Center, Dept. of Neurology, Rigshospitalet -Glostrup
Glostrup, Denmark
|
| 4 |
NCT02984826 |
Completed |
Muscle Strength in Shoulder and Neck Muscles in Tension Type Headache Patients. Effect of Specific Strength Training |
|
- Other: Strength training
- Other: Ergonomic and posture
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
|
- Headache frequency
- Headache Duration
- Intensity of headache
- Medication intake
|
90 |
All |
18 Years to 65 Years (Adult) |
NCT02984826 |
H-3-2009-080 |
|
May 2010 |
June 2012 |
June 2012 |
December 7, 2016 |
December 7, 2016 |
|
- Danish Headache Center Rigshospitalet - Glostrup
Glostrup, Denmark
|
| 5 |
NCT02903329 |
Recruiting |
Comparison of Two Detoxification Protocols for Treatment of Medication-overuse Headache |
- Medication-overuse Headache
|
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Headache frequency
- Days with acute medication/ month
- Headache intensity (Total intensity per month meassured by headache calendars).
- (and 5 more...)
|
100 |
All |
18 Years and older (Adult, Senior) |
NCT02903329 |
H-1-2012-116 |
MUM |
September 2013 |
April 2017 |
September 2017 |
September 16, 2016 |
February 7, 2017 |
|
- Danish Headache Center
Glostrup, Copenhagen, Denmark
|
| 6 |
NCT01525303 |
Completed |
Effects of Aerobic Exercise Within a Behavioral Treatment Program for Chronic Headaches |
|
- Behavioral: Behavioral Treatment for Chronic Headache- Exercise Version
|
Interventional |
Not Applicable |
- University of Mississippi Medical Center
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Patient-reported headache-free days per week
- Headache Disability Index (HDI)
- Highest weekly headache intensity
- Composite Depression/Anxiety Screening Scale (PHQ-4)
|
5 |
Female |
18 Years to 64 Years (Adult) |
NCT01525303 |
2011-0044 |
|
December 2011 |
June 2012 |
August 2012 |
February 2, 2012 |
January 16, 2013 |
|
- University of Mississippi Medical Center
Jackson, Mississippi, United States
|
| 7 |
NCT02467127 |
Enrolling by invitation |
Vitamin D Plasma Level and Its Role in Headache |
|
- Dietary Supplement: vitamin D supplementation
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Treatment
|
- Plasma levels of vitamin D using high performance liquid chromatography
- Headache pain through the Visual Analog Scale (VAS)
|
600 |
All |
18 Years to 55 Years (Adult) |
NCT02467127 |
Headache 2015 |
VITDHEAD |
November 2015 |
September 2016 |
April 2018 |
June 9, 2015 |
January 31, 2017 |
|
- Pugliese Hospital
Catanzaro, Italy
|
| 8 |
NCT02466334 |
Active, not recruiting |
CGRP's Cluster Headache Inducing Abilities in Cluster Headache Patients |
|
- Drug: Calcitonin-Gene Related Peptide
- Drug: Placebo
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Differences in occurence of cluster headache attacks on CGRP day compared to placebo day in all three groups
- AUC headache on CGRP day compared to placebo day in all three groups
- Time to maximum headache score on CGRP day compared to placebo day in all three
|
37 |
All |
18 Years to 65 Years (Adult) |
NCT02466334 |
H-15006836 |
|
June 2015 |
March 2017 |
December 2018 |
June 9, 2015 |
December 19, 2017 |
|
- Danish Headache Center
Copenhagen, Glostrup, Denmark
|
| 9 |
NCT02066558 |
Completed |
Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow |
|
- Other: Carbon monoxide
- Other: Placebo
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Basic Science
|
- Headache scores
- Blood flow velocity
- Artery circumference
- Facial blood flow
|
12 |
All |
18 Years to 50 Years (Adult) |
NCT02066558 |
H-3-2013-194 |
|
February 2014 |
December 2014 |
December 2014 |
February 19, 2014 |
February 12, 2015 |
|
- Danish Headache Center
Glostrup, Denmark
|
| 10 |
NCT02993289 |
Recruiting |
Is Detoxification Needed in Medication-overuse Headache? |
- Medication Overuse Headache
|
- Other: Different well-known treatments
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in headache days per month in group A and C compared to group B.
- Number Needed to Treat based on cured medication-overuse headache in group A and C compared to group B.
- Reduction in headache days per month
- (and 12 more...)
|
115 |
All |
18 Years and older (Adult, Senior) |
NCT02993289 |
H-16029763 |
DEFINE3 |
October 2016 |
October 2017 |
January 2019 |
December 15, 2016 |
December 20, 2016 |
|
- Danish Headache Center
Glostrup, Copenhagen, Denmark
|
| 11 |
NCT02419131 |
Recruiting |
Cognitive-Behavior Therapy for Posttraumatic Headache |
- Post-traumatic Headache
- PTSD
|
- Behavioral: Behavioral Headache Therapy
- Behavioral: Cognitive Processing Therapy
- Behavioral: Treatment as Usual
|
Interventional |
Not Applicable |
- Wake Forest University Health Sciences
- The University of Texas Health Science Center at San Antonio
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Headache-related disability scores on the Headache Impact Test 6 (HIT-6)
- Frequency of headache reported in daily diary records
- Scores for symptoms of post-traumatic stress on the PTSD Checklist-5 (PCL-5)
|
285 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02419131 |
HSC20140339H |
|
May 2015 |
December 2018 |
December 2018 |
April 17, 2015 |
November 6, 2017 |
|
- San Antonio VA Medical Center
San Antonio, Texas, United States
|
| 12 |
NCT03156920 |
Completed |
Pretreatment With Sumatriptan on Cilostazol Induced Headache in Healthy Volunteers |
|
- Drug: Placebo
- Drug: Sumatriptan
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Difference in median headache score 2 hours after cilostazol
- Area under the headache score curve
- Difference in peak headache score
|
30 |
All |
18 Years to 60 Years (Adult) |
NCT03156920 |
H-15011960 |
|
May 23, 2017 |
October 18, 2017 |
October 18, 2017 |
May 17, 2017 |
October 19, 2017 |
|
- Katrine Falkenberg
Copenhagen, Glostrup, Denmark
|
| 13 |
NCT02486276 |
Completed |
The Effect of Sumatriptan and Placebo on Cilostazol Induced Headache |
|
- Drug: Cilostazol
- Drug: Sumatriptan
- Drug: Placebo
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Difference in median headache score 2 hours after sumatriptan/placebo
- Area under the headache score curve
|
30 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02486276 |
H-8-2014-009 |
|
June 2015 |
June 2016 |
June 2016 |
July 1, 2015 |
May 9, 2017 |
|
- Emma Katrine Hansen
Copenhagen, Glostrup, Denmark
|
| 14 |
NCT02176655 |
Completed
Has Results |
Pilot Study of VVD-101 for the Treatment of Delayed Alcohol-Induced Headaches |
- Delayed Alcohol Induced Headache
|
- Drug: VVD-101
- Drug: Placebo
|
Interventional |
Phase 2 |
- Cady, Roger, M.D.
- Vivid Pharma Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Headache Severity 2 Hours Post Treatment
- Headache Severity at Treatment, 30 Minutes and 1 Hour Post Treatment
- Number of Headaches Relieved
- (and 5 more...)
|
31 |
All |
21 Years and older (Adult, Senior) |
NCT02176655 |
14-001VI |
|
July 2014 |
January 2016 |
January 2016 |
June 27, 2014 |
March 23, 2017 |
March 23, 2017 |
- South Drive Medical Clinic
Mountain View, California, United States - Clinvest
Springfield, Missouri, United States
|
| 15 |
NCT03231241 |
Recruiting |
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics |
- Chronic Daily Headache
- Chronic Migraine
|
|
Observational |
|
|
Other |
- Observational Model: Ecologic or Community
- Time Perspective: Cross-Sectional
|
- Prediction of chronification of headache
|
700 |
All |
18 Years and older (Adult, Senior) |
NCT03231241 |
SunStar |
|
December 12, 2014 |
August 15, 2020 |
May 1, 2021 |
July 27, 2017 |
July 27, 2017 |
|
- Stanford University School of Medicine
Stanford, California, United States
|
| 16 |
NCT01899040 |
Completed |
A Non-Invasive Neuromodulation Device for Treatment of Migraine Headache |
- Migraine Headache, Episodic
|
- Device: neuromodulation for episodic migraine headache
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Number of monthly migraine headache days
- Number of monthly migraine headache days (reduction by by 50% or more)
- Total monthly pain score
- (and 4 more...)
|
81 |
All |
18 Years to 65 Years (Adult) |
NCT01899040 |
SNS-MIG-01 |
|
August 2013 |
May 2016 |
June 2016 |
July 15, 2013 |
October 18, 2016 |
|
- Naval Medical Center
San Diego, California, United States - Michigan Headache and Neurological Institute
Ann Arbor, Michigan, United States - Carolina Headache Institute
Chapel Hill, North Carolina, United States - (and 3 more...)
|
| 17 |
NCT02746250 |
Unknown † |
Muscle Soreness and Stiffness in Patients With Chronic or Frequent Episodic Tension Type Headache. |
|
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Change in Total Tenderness Score
- Change in muscle stiffness
- Change in Local Tenderness Score
|
90 |
All |
18 Years to 65 Years (Adult) |
NCT02746250 |
H-16000619 |
|
March 2016 |
January 2017 |
February 2017 |
April 21, 2016 |
April 21, 2016 |
|
- Danish Headache center
Glostrup, Denmark
|
| 18 |
NCT01750723 |
Completed |
Acetazolamide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow |
|
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Headache scores
- Artery circumference
- Cerebral blood flow
|
12 |
All |
18 Years to 50 Years (Adult) |
NCT01750723 |
H-3-2012-137 |
|
December 2012 |
April 2013 |
April 2013 |
December 17, 2012 |
July 9, 2013 |
|
- Danish Headache Center
Copenhagen, Glostrup, Denmark - Department of Neurology
Copenhagen, Glostrup, Denmark
|
| 19 |
NCT03500861 |
Completed
New |
Trigger Point Dry Needling for Chronic Tension-Type Headache |
- Tension-Type Headache
- Trigger Points
|
|
Interventional |
Not Applicable |
- Eastern Mediterranean University
|
Other |
- Allocation: Randomized
- Intervention Model: Sequential Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The headache intensity
- The headache frequency
- The headache duration
- The quality of life
|
160 |
All |
20 Years to 50 Years (Adult) |
NCT03500861 |
ETK00-2017-0121 |
|
April 1, 2017 |
August 1, 2017 |
August 30, 2017 |
April 17, 2018 |
April 17, 2018 |
|
- 1. Eastern Mediterranean University Health Sciences Faculty, Department of Physiotherapy and Rehabilitation,
Ankara, Turkey
|
| 20 |
NCT02887638 |
Not yet recruiting |
Headache Analysis and Intervention |
|
- Other: Individual Profile Analysis (Physical therapy Intervention)
|
Interventional |
Not Applicable |
- Hasselt University
- Katholieke Universiteit Leuven
- Ziekenhuis Oost-Limburg
- (and 3 more...)
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Investigator)
- Primary Purpose: Diagnostic
|
- Sitting-posture-profile
- Dural-profile
- Pain-Profile
- (and 2 more...)
|
152 |
All |
20 Years to 50 Years (Adult) |
NCT02887638 |
PHA-2016 |
PRA |
November 2016 |
May 2022 |
May 2022 |
September 2, 2016 |
September 2, 2016 |
|
- Ziekenhuis Oost-Limburg
Genk, Belgium - Jessa Ziekenhuis
Hasselt, Belgium - Leuven University
Leuven, Belgium - (and 2 more...)
|
| 21 |
NCT01854385 |
Completed |
Sumatriptan as Treatment for Post-traumatic Headache |
|
|
Interventional |
Phase 2 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Headache relief
- Adverse events
- Compliance
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT01854385 |
44912 |
TWIST |
June 2013 |
February 2018 |
February 2018 |
May 15, 2013 |
March 27, 2018 |
|
- Harborview Medical Center
Seattle, Washington, United States - University of Washington Medical Center
Seattle, Washington, United States
|
| 22 |
NCT01327118 |
Completed |
Prostaglandin F2alpha in a Human Headache Model |
|
- Drug: Prostaglandin F2alpha
- Drug: Isoton sodium chloride
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
|
- Headache score on a 10-point verbal rating scale (VRS) 0 indicated no headache; 1 indicated a different sensation, pounding or throbbing, but not necessarily painful; 5 indicated moderate headache and 10 indicated worst imaginable headache
- Blood flow velocity in the middle cerebral artery (VMCA) measured by a Transcranial Doppler (TCD) ultrasonography (2MHz)
- diameter of superficial temporal artery and radial artery measured by a high resolution ultrasound scanner, C-scan
- (and 2 more...)
|
12 |
All |
18 Years to 40 Years (Adult) |
NCT01327118 |
DHC-PGF2-2010 |
|
September 2010 |
December 2010 |
December 2010 |
April 1, 2011 |
April 14, 2011 |
|
- Danish Headache Center
Glostrup, Denmark
|
| 23 |
NCT01637662 |
Completed |
Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow |
|
- Drug: Natriuretic peptides
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Screening
|
- Headache intensity, mean velocity of blood flow in the middle cerebral artery (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were recorded at T-10, T0 and then every 10 min until 120 min after start of infusion.
- All subjects were asked to complete a headache diary every hour until 10 h after the discharge. The diary included headache characteristics and accompanying symptoms according to the International Headache Society (IHS 2004)
|
6 |
All |
18 Years to 40 Years (Adult) |
NCT01637662 |
H-3-2012-065 |
|
July 2012 |
January 2014 |
|
July 11, 2012 |
July 29, 2015 |
|
- Danish Headache Center
Copenhagen, Glostrup, Denmark
|
| 24 |
NCT00389038 |
Unknown † |
Pediatric Chronic Headache Trial |
|
- Behavioral: Coping Skills Training
- Behavioral: Headache Education
- Drug: Amitriptyline
|
Interventional |
Phase 3 |
- Children's Hospital Medical Center, Cincinnati
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Headache diaries assess headache frequency.
- The Child Depression Inventory.
- The PedsQL measures the impact of chronic illness and quality of life.
- Pediatric Migraine Disability Assessment (PedMIDAS) evaluates the impact of headaches on life activities.
|
132 |
All |
10 Years to 17 Years (Child) |
NCT00389038 |
R01NS050536
1R01NS050536-01A1 |
|
October 2006 |
August 2012 |
September 2012 |
October 17, 2006 |
April 25, 2011 |
|
- Cincinnati Children's Hospital Medical Center, 3333 Burnet Avenue, Mail Location 3015
Cincinnati, Ohio, United States
|
| 25 |
NCT03427372 |
Not yet recruiting |
The Effect of Tobacco Use and Psychological State on Post Spinal Puncture Headache and Backache |
- Depression, Anxiety
- Tobacco Use
|
- Behavioral: headache, backache, anxiety, depression
|
Observational |
|
- Ahi Evran University Education and Research Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- post spinal puncture headache (PDPH)
- anxiety
- depression
- (and 2 more...)
|
500 |
All |
18 Years to 80 Years (Adult, Senior) |
NCT03427372 |
post dural puncture headache |
|
February 2018 |
May 2018 |
May 2018 |
February 9, 2018 |
February 13, 2018 |
|
- Ahi evran university education and research hospital
Kırşehir, Turkey
|
| 26 |
NCT02991430 |
Recruiting |
A Non-Invasive Neuromodulation Device for Prevention of Episodic Migraine Headache |
|
- Device: active neuromodulation for episodic migraine headache
- Device: placebo neuromodulation for episodic migraine headache
|
Interventional |
Not Applicable |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in migraine headache days (MHD)
- normalized reduction in migraine headache days
- change in medication usage
- (and 7 more...)
|
120 |
All |
18 Years to 65 Years (Adult) |
NCT02991430 |
SNS-MIG-02 |
|
June 30, 2017 |
July 2018 |
September 2018 |
December 13, 2016 |
October 31, 2017 |
|
- Mayo Clinic
Scottsdale, Arizona, United States - Neurology Research Institute
West Palm Beach, Florida, United States - Diamond Headache Clinic
Chicago, Illinois, United States - (and 7 more...)
|
| 27 |
NCT03426800 |
Recruiting |
Acupuncture - a Treatment for Children With Headache |
|
- Other: Acupuncture and training
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
204 |
All |
9 Years to 17 Years (Child) |
NCT03426800 |
RHN_DMK_01 |
|
September 1, 2017 |
December 31, 2019 |
December 31, 2020 |
February 8, 2018 |
February 9, 2018 |
|
- North Denmark Hospital
Hjørring, Denmark
|
| 28 |
NCT00399243 |
Unknown † |
Sumatriptan 4 mg Statdose in the Acute Treatment of Cluster Headache |
- Episodic Cluster Headache
- Chronic Cluster Headache
|
- Drug: Sumatriptan 4mg Statdose injection
|
Interventional |
Phase 4 |
- Diamond Headache Clinic
- GlaxoSmithKline
- Diamond Headache Clinic
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary efficacy parameters will be the percentage of cluster headache attacks that result in the cluster headache pain being reduced to mild or none following a single dose of 4 mg subcutaneous sumatriptan at 15 minutes and at 30 minutes.
- The time meaningful relief of cluster headache.
- The percentage of attacks that produce a pain free response to a single dose of sumatriptan 4 mg subcutaneous at 15 minutes, 30 minutes and at 1 hour.
- (and 10 more...)
|
20 |
All |
18 Years to 65 Years (Adult) |
NCT00399243 |
DHC08 |
|
November 2006 |
August 2010 |
August 2010 |
November 14, 2006 |
February 2, 2009 |
|
- Diamond Headache Clinic
Chicago, Illinois, United States
|
| 29 |
NCT03422796 |
Recruiting |
The Effect of Sumatriptan and Placebo Injection on Cilostazol Induced Headache |
|
- Drug: Cilostazol 200mg
- Drug: SUMAtriptan 6 MG/ML
- Drug: Placebo
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Difference in median headache score 2 hours after sumatriptan/placebo
|
30 |
All |
18 Years to 65 Years (Adult) |
NCT03422796 |
H-17026731 |
|
November 1, 2017 |
September 2018 |
September 2018 |
February 6, 2018 |
February 6, 2018 |
|
- Rigshospitalet Glostrup
Glostrup, Denmark
|
| 30 |
NCT02485340 |
Completed |
The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache |
|
- Drug: 5-ISMN (isosorbide-5-mononitrate)
- Drug: Sumatriptan
- Drug: Placebo
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Median headache score 0 hours after sumatriptan/placebo
- Median headache score 2 hours after sumatriptan/placebo
|
30 |
All |
18 Years to 70 Years (Adult, Senior) |
NCT02485340 |
H-6-2014-071 |
|
April 2015 |
August 2015 |
August 2015 |
June 30, 2015 |
January 22, 2016 |
|
- Emma Katrine Hansen
Copenhagen, Glostrup, Denmark
|
| 31 |
NCT02195648 |
Unknown † |
Sub-occipital Muscle Inhibition in Tension Type Headache |
|
- Other: Experimental: Treatment of sub-occipital muscle inhibition
|
Interventional |
Not Applicable |
- Universidad Católica San Antonio de Murcia
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change of assessment of upper cervical range of motion
- Change of predictive quality of life
- Change of pain intensity
- (and 3 more...)
|
60 |
All |
18 Years to 65 Years (Adult) |
NCT02195648 |
tension type headache |
TTH |
September 2014 |
November 2014 |
August 2015 |
July 21, 2014 |
July 21, 2014 |
|
- Universidad Católica San Antonio de Murcia
Murcia, Guadalupe, Spain
|
| 32 |
NCT00918671 |
Completed
Has Results |
Medication-overuse Headache: 4 Years Follow up |
- Medication Overuse Headache
|
- Other: No new specific intervention
|
Observational |
|
- Norwegian University of Science and Technology
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in Headache Days/Month After 4 Years Compared to Baseline
- Change of Medication Days/Month Compared to Baseline
|
60 |
All |
22 Years to 74 Years (Adult, Senior) |
NCT00918671 |
4.2007.2192
07/4471
17429 |
MOHfollowup |
January 2008 |
May 2010 |
May 2010 |
June 11, 2009 |
November 3, 2016 |
December 30, 2010 |
- Norwegian National headache Centre, NTNU
Trondheim, Norway
|
| 33 |
NCT01172405 |
Unknown † |
Efficacy and Safety Study to Compare Ibuprofen + Caffeine With Ibuprofen Alone in the Treatment of Headache |
|
- Drug: Ibuprofen plus caffeine
- Drug: Ibuprofen
|
Interventional |
Phase 3 |
- Mantecorp Industria Quimica e Farmaceutica Ltd.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Efficacy of study treatment compared with control to relieve headache symptoms.
- Tolerability of study treatment compared with control to relieve headache symptoms.
|
144 |
All |
18 Years to 65 Years (Adult) |
NCT01172405 |
IBU-CAF-01/09 |
|
October 2010 |
October 2012 |
October 2012 |
July 29, 2010 |
July 29, 2010 |
|
|
| 34 |
NCT02270177 |
Completed |
Telemedicine Versus Traditional Specialist Consultation for Headache: a Non-inferiority Trial |
|
- Other: Telemedicine, videoconsultation
|
Interventional |
Not Applicable |
- University Hospital of North Norway
- University of Tromso
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
- Number of satisfied participants
- VAS satisfaction rating scale
- VAS pain scale
- (and 5 more...)
|
402 |
All |
16 Years to 65 Years (Child, Adult) |
NCT02270177 |
2009/1430 REK sør-øst
FAS nr: 692
HST959-10 |
VHS |
September 2012 |
June 2016 |
June 2016 |
October 21, 2014 |
June 14, 2016 |
|
- Department of Neurology, University Hospital of North Norway
Tromsø, Troms, Norway
|
| 35 |
NCT02640105 |
Unknown † |
Cluster Headache, Addictions and Vascular Function |
|
- Other: Neurological clinical examination
- Other: Psychological clinical examination
- Other: Questionnaires
- (and 2 more...)
|
Observational |
|
- University Hospital, Bordeaux
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Duration of active periods of cluster headache
- Number of active periods
- Duration of cluster headache
- (and 4 more...)
|
150 |
All |
18 Years and older (Adult, Senior) |
NCT02640105 |
CHUBX 2013/14 |
CHAD |
June 2014 |
June 2017 |
June 2017 |
December 28, 2015 |
December 28, 2015 |
|
- CHU de Bordeaux
Bordeaux, France
|
| 36 |
NCT02657031 |
Completed
Has Results |
The CHECK Trial: A Comparison of Headache Treatment in the ED: Compazine Versus Ketamine |
|
- Drug: Prochlorperazine
- Drug: Ketamine
- Drug: Diphenhydramine
- (and 2 more...)
|
Interventional |
Phase 4 |
- University Medical Center of Southern Nevada
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Headache Following Intervention
- Anxiety
- Nausea
- (and 2 more...)
|
54 |
All |
18 Years to 65 Years (Adult) |
NCT02657031 |
EM 2015.13 |
|
March 17, 2016 |
March 21, 2017 |
March 21, 2017 |
January 15, 2016 |
December 11, 2017 |
December 11, 2017 |
- University Medical Center of Southern Nevada
Las Vegas, Nevada, United States
|
| 37 |
NCT02160535 |
Terminated |
Treatment of Chronic Post-Traumatic Headache With OnabotulinumtoxinA |
- Chronic Post Traumatic Headache
|
|
Interventional |
Phase 3 |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- To determine whether OnabotulinumtoxinA is an effective treatment for chronic post-traumatic headache (PTH) following mild traumatic brain injury (mTBI).
- To assess whether treatment results in improvement of quality of life and a reduction of disability in individuals suffering from chronic PTH.
|
13 |
All |
18 Years to 60 Years (Adult) |
NCT02160535 |
46614-A |
|
May 2014 |
August 2016 |
August 2016 |
June 10, 2014 |
March 1, 2017 |
|
- University of Washington Headache Clinic
Seattle, Washington, United States
|
| 38 |
NCT03113357 |
Completed |
The Effect of Myofascial Release in Patients With Cervicogenic Headache |
|
- Other: Myofascial release technique
- Other: conventional exercise therapy
|
Interventional |
Not Applicable |
- University of Social Welfare and Rehabilitation Science
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- headache severity
- headache frequency
- headache duration
- pressure pain threshold
|
34 |
All |
15 Years to 75 Years (Child, Adult, Senior) |
NCT03113357 |
931672006 |
RCT |
January 2015 |
September 2016 |
November 2016 |
April 13, 2017 |
April 13, 2017 |
|
- University of Social Welfare and Rehabilitation Sciences
Tehran, Islamic Republic of, Iran, Islamic Republic of
|
| 39 |
NCT00957983 |
Completed |
EP4-receptor Antagonism and Prostaglandin E2 (PGE2) in a Human Headache Model |
|
|
Interventional |
Phase 1
Phase 2 |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Headache
- rCBF, blood flow, diameter of STA/RA, HR, BP
|
8 |
All |
18 Years to 40 Years (Adult) |
NCT00957983 |
BGC20-1531-04 |
|
August 2009 |
February 2010 |
February 2010 |
August 13, 2009 |
January 11, 2011 |
|
- Danish Headache Center
Glostrup, Denmark
|
| 40 |
NCT02295280 |
Completed
Has Results |
A Cost Effective Treatment for Headache in Pregnancy When Acetaminophen Alone is Ineffective. |
|
- Drug: Metoclopramide
- Drug: Diphenhydramine
- Drug: Codeine
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Prevention
|
- Number of Participants With Adequate Relief of Headache as a Measure of Efficacy
|
70 |
Female |
16 Years to 50 Years (Child, Adult) |
NCT02295280 |
15742 |
MAD |
January 2012 |
November 2014 |
November 2014 |
November 20, 2014 |
April 2, 2018 |
April 2, 2018 |
- Saint Louis University
Saint Louis, Missouri, United States
|
| 41 |
NCT00315666 |
Completed |
Prophylactic Effect of Memantine in Chronic Tension-Type Headache |
|
|
Interventional |
Phase 3 |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Headache duration
- Headache intensity
- Headache frequency
- (and 2 more...)
|
40 |
All |
18 Years to 65 Years (Adult) |
NCT00315666 |
2006-000060-82
KA-20060021 |
|
May 2006 |
June 2007 |
June 2007 |
April 19, 2006 |
February 20, 2009 |
|
- Danish Headaches Center
Glostrup, Denmark
|
| 42 |
NCT03250754 |
Active, not recruiting |
Treatment of Chronic Refractory Headache With Acupuncture: Observational Study: OBSERVATIONAL STUDY (CRHACU) |
- Chronic Headache Disorder
|
- Device: Electroacupuncture
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Retrospective
|
- Number of days with headache per month
- Visual analogue scale (VAS) for pain
- The change of headache days after 1 month
- (and 2 more...)
|
320 |
All |
18 Years and older (Adult, Senior) |
NCT03250754 |
CRHACU-001 |
CRHACU |
March 20, 2017 |
July 30, 2017 |
April 20, 2018 |
August 16, 2017 |
March 26, 2018 |
|
- Son Llàtzer University Hospital
Palma, Balearic Islands, Spain
|
| 43 |
NCT03330639 |
Not yet recruiting |
Capsaicin in Treatment of Rhinogenic Headache |
|
- Other: Capsaicin
- Other: Placebo
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- headache medication use
- number of patients with treatment related adverse events
- headache frequency and severity
|
36 |
All |
19 Years to 100 Years (Adult, Senior) |
NCT03330639 |
156522 |
|
November 2018 |
September 2019 |
December 2019 |
November 6, 2017 |
February 1, 2018 |
|
|
| 44 |
NCT03416114 |
Recruiting |
RegistRare: a Retro-prospective Registry of Rare Primary Headaches in Italian Tertiary Headache Centres |
|
|
Observational |
|
- Silvia Benemei
- University of Modena and Reggio Emilia
- University of Roma La Sapienza
- (and 5 more...)
|
Other |
- Observational Model: Cohort
- Time Perspective: Other
|
- Incidence and prevalence in Tertiary headache Centres
|
3000 |
All |
Child, Adult, Senior |
NCT03416114 |
RegistRare |
RegistRare |
September 1, 2017 |
August 2027 |
August 2027 |
January 30, 2018 |
January 30, 2018 |
|
- Careggi University Hospital
Florence, Italy
|
| 45 |
NCT01601015 |
Completed |
Effectiveness of the Treatment of Tension-type Headache With Manual and Manipulative Therapy |
|
- Other: Manual Therapy
- Other: placebo treatment
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Factorial Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- An individual clinical interview was conducted to collect socio-demographic data and characteristics of headache in a one-month base period (the previous 4 weeks)
- Multidimensional perception of pain, assessed by the McGill Pain Questionnaire
- Cervical ranges of motion, measured with the CROM-device
- Weekly register
|
84 |
All |
18 Years to 65 Years (Adult) |
NCT01601015 |
UVT002 |
|
January 2010 |
December 2010 |
December 2011 |
May 17, 2012 |
May 17, 2012 |
|
- Gemma V Espí López
Valencia, Spain
|
| 46 |
NCT00255320 |
Completed |
Experimental Headache Induced by Vasoactive Intestinal Polypeptide |
- Healthy Volunteers, Headache, Migraine, Hemodynamics, VIP, SPECT, Ultrasound
|
|
Interventional |
Not Applicable |
- Danish Headache Center
- Danish Headache Center
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double
- Primary Purpose: Diagnostic
|
- Headache intensity, Mean velocity of blood flow in the middle cerebral artery (VmeanMCA), superfical temporal artery diameter, PetCO2, adverse events and vital signs were recorded at T-10, T0 and then every 10 min until 120 min after start of infusion.
- All subjects were asked to complete a headache diary every hour until 10 h after the discharge. The diary included headache characteristics and accompanying symptoms according to the International Headache Society (IHS 2004)
|
12 |
All |
18 Years to 60 Years (Adult) |
NCT00255320 |
VIP-KASGlo2004 |
|
December 2003 |
|
June 2004 |
November 18, 2005 |
December 9, 2005 |
|
- Danish Headache Center , KAS Glostrup
Glostrup, Copenhagen, Denmark
|
| 47 |
NCT01704625 |
Unknown † |
Will the Use of Osteopathic Manipulative Treatments Help Alleviate Headache Pain |
|
- Procedure: Osteopathic Manipulative Treatment
- Procedure: Sham Osteopathic Manipulative Treatment
|
Interventional |
Not Applicable |
- Good Samaritan Hospital Medical Center, New York
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Care Provider)
- Primary Purpose: Treatment
|
- Headache Pain as Measured by a VAS
|
50 |
All |
21 Years and older (Adult, Senior) |
NCT01704625 |
11-013 |
|
January 2012 |
December 2012 |
December 2012 |
October 11, 2012 |
October 11, 2012 |
|
- Good Samaritan Hospital Medical Center
West Islip, New York, United States
|
| 48 |
NCT02870725 |
Completed |
CBT Depression Intervention for Co-Occurring Chronic Headache |
- Depression
- Headaches Chronic
- Migraine Disorders
|
- Behavioral: CBT Individual Psychotherapy
|
Interventional |
Not Applicable |
- University of Georgia
- Henry Ford Health System
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean change in "Beck Depression Inventory (BDI-2)"
- Mean change in "Headache Disability Index"
- Mean change in "Migraine Disability Assessement Questionnaire (MIDAS)"
- (and 2 more...)
|
22 |
All |
18 Years to 75 Years (Adult, Senior) |
NCT02870725 |
002322 |
|
November 2016 |
June 22, 2017 |
July 1, 2017 |
August 17, 2016 |
July 6, 2017 |
|
- University of Georgia
Athens, Michigan, United States - Henry Ford Hospital
Detroit, Michigan, United States
|
| 49 |
NCT01298921 |
Unknown † |
A Pilot Study of Demand Valve Oxygen Inhalation Therapy for Cluster Headache |
|
|
Interventional |
Phase 1 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Reduction in headache pain
- Headache relief and pain free
|
12 |
All |
18 Years to 65 Years (Adult) |
NCT01298921 |
2010-0205 |
|
January 2011 |
October 2012 |
November 2012 |
February 18, 2011 |
March 16, 2012 |
|
- Geisinger Wyoming Valley
Wilkes-Barre, Pennsylvania, United States
|
| 50 |
NCT01552798 |
Terminated |
Efficacy of a Single Dose of Aspirin vs. Acetaminophen in Tension Type Headache |
|
- Drug: Acetylsalicylic acid (Aspirin, BAY1019036)
- Drug: Acetaminophen
- Drug: Placebo
|
Interventional |
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Time to meaningful pain relief (defined as the time when the subject indicates pain relief that is meaningful to the subject)
- Time to first perceptible relief
- Time to first perceptible relief confirmed
- (and 12 more...)
|
9 |
All |
18 Years to 65 Years (Adult) |
NCT01552798 |
15771 |
Tarot Headache |
March 2012 |
June 2012 |
June 2012 |
March 13, 2012 |
January 15, 2016 |
|
- Kalamazoo, Michigan, United States
|
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