23 studies found for:    GIST | Open Studies | United States
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Rank Status Study
1 Recruiting BGJ398 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)
Condition: Advanced Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: BGJ398;   Drug: Imatinib Mesylate
2 Unknown  A Phase 3 Study to Evaluate Efficacy and Safety of Masitinib in Comparison to Imatinib in Patients With Gastro-Intestinal Stromal Tumour in First Line Medical Treatment
Condition: Gastrointestinal Stromal Tumors
Interventions: Drug: masitinib (AB1010);   Drug: imatinib
3 Recruiting PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors
Condition: Gastrointestinal Stromal Tumors
Interventions: Drug: PLX9486;   Drug: PLX3397
4 Recruiting Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
Conditions: Gastrointestinal Stromal Tumors (GIST);   Other Relapsed or Refractory Solid Tumors
Intervention: Drug: BLU-285
5 Recruiting A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor
Condition: Gastrointestinal Stromal Tumors
Interventions: Drug: sunitinib malate dose escalation;   Drug: sunitinib malate
6 Recruiting Study of the Glutaminase Inhibitor CB-839 in Solid Tumors
Conditions: Solid Tumors;   Triple-Negative Breast Cancer;   Non Small Cell Lung Cancer;   Renal Cell Carcinoma;   Mesothelioma;   Fumarate Hydratase (FH)-Deficient Tumors;   Succinate Dehydrogenase (SDH)-Deficient Gastrointestinal Stromal Tumors (GIST);   Succinate Dehydrogenase (SDH)-Deficient Non-gastrointestinal Stromal Tumors;   Tumors Harboring Isocitrate Dehydrogenase-1 (IDH1) and IDH2 Mutations;   Tumors Harboring Amplifications in the cMyc Gene
Interventions: Drug: CB-839;   Drug: Pac-CB;   Drug: CBE;   Drug: CB-Erl;   Drug: CBD
7 Recruiting Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract
Conditions: Pancreatic Cyst;   Pancreatic Neoplasms;   Pancreatic Adenoma;   Pancreatic Cancer;   Pancreatic Islet Cell Tumors;   Lymph Node Mass;   Lymphadenopathy;   GIST
Intervention: Device: Endoscopic ultrasound fine needle aspiration
8 Recruiting Cancer Research Repository for Individuals With Cancer Diagnosis and High Risk Individuals.
Conditions: Pancreatic Cancer;   Thyroid Cancer;   Lung Cancer;   Esophageal Cancer;   Thymus Cancer;   Colon Cancer;   Rectal Cancer;   GIST;   Anal Cancer;   Bile Duct Cancer;   Duodenal Cancer;   Gallbladder Cancer;   Gastric Cancer;   Liver Cancer;   Small Intestine Cancer;   Peritoneal Surface Malignancies;   Familial Adenomatous Polyposis;   Lynch Syndrome;   Bladder Cancer;   Kidney Cancer;   Penile Cancer;   Prostate Cancer;   Testicular Cancer;   Ureter Cancer;   Urethral Cancer;   Hypopharyngeal Cancer;   Laryngeal Cancer;   Lip Cancer;   Oral Cavity Cancer;   Nasopharyngeal Cancer;   Oropharyngeal Cancer;   Paranasal Sinus Cancer;   Nasal Cavity Cancer;   Salivary Gland Cancer;   Skin Cancer;   CNS Tumor;   CNS Cancer;   Mesothelioma
Intervention:
9 Recruiting A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
Conditions: Gastrointestinal Stromal Tumors;   Aggressive Systemic Mastocytosis;   Advanced Cancers
Intervention: Drug: DCC-2618
10 Recruiting MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)
Condition: Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: MEK162;   Drug: Imatinib Mesylate (Gleevec®; STI571; NSC #716051);   Other: Blood draws;   Procedure: biopsy
11 Recruiting Phase Ib Study of SUnitinib Alternating With REgorafenib in Patients With Metastatic and/or Unresectable GIST
Condition: Gastrointestinal Stromal Tumor
Interventions: Drug: Sunitinib;   Drug: Regorafenib
12 Recruiting Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy
Condition: Gastric Cancers
Intervention:
13 Recruiting Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001
Condition: Gastrointestinal Stromal Tumor
Interventions: Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis
14 Recruiting SARC024: A Blanket Protocol to Study Oral Regorafenib in Patients With Refractory Liposarcoma, Osteogenic Sarcoma, and Ewing Sarcomas
Conditions: Liposarcoma;   Osteogenic Sarcoma;   Ewing/Ewing-like Sarcoma
Interventions: Drug: Regorafenib;   Drug: Placebo
15 Recruiting Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal Tumor
Conditions: Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Gastrointestinal Stromal Tumor;   Premenopausal
Interventions: Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration;   Procedure: Ultrasonography
16 Recruiting TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors
Conditions: Pancreatic Cancer;   Colorectal Cancer;   Rectal Cancer;   Gastric Cancer;   Esophageal Cancer;   Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: TGR-1202;   Drug: nab-paclitaxel + gemcitabine;   Drug: Oxaliplatin + Folinic acid + Fluorouracil;   Drug: Oxaliplatin + Folinic acid + Fluorouracil + Bevacizumab
17 Recruiting Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
Conditions: Stomach Cancer;   Gastro-Esophageal(GE) Junction Cancer;   Gastric (Stomach) Cancer;   Esophageal Cancer;   Gastrointestinal Stromal Tumor (GIST)
Interventions: Procedure: Blood draw;   Procedure: Tissue tumor biopsy
18 Unknown  Ph II of Capecitabine, Carboplatin & Bevacizumab for Gastroesophageal Junction & Gastric Carcinoma
Conditions: Stomach Cancer;   Gastric (Stomach) Cancer;   Neoplasm of Cardioesophageal Junction;   Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: bevacizumab;   Drug: carboplatin;   Drug: capecitabine
19 Recruiting Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
Conditions: Malignant Solid Tumour;   Breast Cancer;   Malignant Tumor of Colon;   GIST;   Ovarian Cancer
Intervention: Biological: HER-2 vaccine
20 Recruiting Efficacy and Safety of the Combination Therapy of Dabrafenib and Trametinib in Subjects With BRAF V600E- Mutated Rare Cancers
Condition: Cancer
Interventions: Drug: Dabrafenib;   Drug: Trametinib

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