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25 studies found for:    GIST | Open Studies | United States
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Rank Status Study
1 Recruiting MEK162 in Combination With Imatinib Mesylate in Patients With Untreated Advanced Gastrointestinal Stromal Tumor (GIST)
Condition: Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: MEK162;   Drug: Imatinib Mesylate (Gleevec®; STI571; NSC #716051);   Other: Blood draws;   Procedure: biopsy
2 Recruiting A Phase II Trial of the Mitogen Activated Protein Kinase Kinase (MEK1/2) Inhibitor Selumetinib (AZD6244 Hydrogen Sulfate) in Patients With Neurofibromatosis Type 1 (NF1) Mutated Gastrointestinal Stromal Tumors (GIST)
Conditions: Neoplasms, Nerve Tissue;   Neurofibromatosis 1;   Heredodegenerative Disorders, Nervous System;   Peripheral Nervous System Diseases
Intervention: Drug: Selumetinib (AZD6244 hyd sulfate)
3 Not yet recruiting Efficacy of Ferric Carboxymaltose in Patients With Gastrointestinal Stromal Tumor (GIST) Receiving Systemic Therapy
Conditions: Malignant Neoplasms of Mesothelial and Soft Tissue;   Gastrointestinal Stromal Tumor With Neurogenic Differentiation
Interventions: Drug: Ferric Carboxymaltose;   Dietary Supplement: Iron Supplements;   Behavioral: Questionnaire
4 Recruiting Study of Tumor Samples in Patients Undergoing Treatment for Gastrointestinal Stromal Tumors on Clinical Trial ACOSOG-Z9001
Condition: Gastrointestinal Stromal Tumor
Interventions: Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis
5 Recruiting Tissue Procurement for Gastric Cancer, Gastrointestinal Stromal Tumors (GIST), Esophageal Cancer, Pancreas Cancer, Hepatocellular Cancer, Biliary Cancer, Neuroendocrine, Peritoneal Mesothelioma, Anal Cancer and Colorectal Cancer in Patients Undergoing Surgery or Biopsy
Condition: Gastric Cancers
Intervention:
6 Recruiting Nivolumab With or Without Ipilimumab in Treating Patients With Gastrointestinal Stromal Tumor That Is Metastatic or Cannot Be Removed by Surgery
Condition: Gastrointestinal Stromal Tumor
Interventions: Biological: Ipilimumab;   Other: Laboratory Biomarker Analysis;   Biological: Nivolumab
7 Recruiting Long Term Effects of Tyrosine Kinase Inhibitor Therapy on Ovarian Reserve and Fertility in Patients With Chronic Myeloid Leukemia or Gastrointestinal Stromal Tumor
Conditions: Chronic Myelogenous Leukemia, BCR-ABL1 Positive;   Gastrointestinal Stromal Tumor;   Premenopausal
Interventions: Other: Cytology Specimen Collection Procedure;   Other: Laboratory Biomarker Analysis;   Other: Questionnaire Administration;   Procedure: Ultrasonography
8 Recruiting Platelet and Tissue cAMP: Novel Biomarkers of Milrinone Efficacy in Children
Conditions: Pediatrics;   Heart Failure;   Congenital Heart Disease;   Therapeutics
Intervention:
9 Recruiting PLX9486 as a Single Agent and in Combination With PLX3397 in Patients With Advanced Solid Tumors
Condition: Gastrointestinal Stromal Tumors
Interventions: Drug: PLX9486;   Drug: PLX3397
10 Recruiting Randomized Trial of Crenolanib in Subjects With D842V Mutated GIST
Condition: GIST With D842V Mutated PDGFRA Gene
Interventions: Drug: Crenolanib;   Drug: Placebo
11 Recruiting Phase 1 Study of BLU-285 in Patients With Gastrointestinal Stromal Tumors (GIST) and Other Relapsed and Refractory Solid Tumors
Conditions: Gastrointestinal Stromal Tumors (GIST);   Other Relapsed or Refractory Solid Tumors
Intervention: Drug: BLU-285
12 Recruiting Clinical Registry of nCLE in Masses and Cystic Tumors of the Pancreas, Lymph Nodes, Submucosal Lesions of the GI Tract
Conditions: Pancreatic Cyst;   Pancreatic Neoplasms;   Pancreatic Adenoma;   Pancreatic Cancer;   Pancreatic Islet Cell Tumors;   Lymph Node Mass;   Lymphadenopathy;   GIST
Intervention: Device: Endoscopic ultrasound fine needle aspiration
13 Recruiting A Study of Sunitinib In Young Patients With Advanced Gastrointestinal Stromal Tumor
Condition: Gastrointestinal Stromal Tumors
Interventions: Drug: sunitinib malate dose escalation;   Drug: sunitinib malate
14 Recruiting Clinical & Pathological Studies of Upper Gastrointestinal Carcinoma
Conditions: Stomach Cancer;   Gastro-Esophageal(GE) Junction Cancer;   Gastric (Stomach) Cancer;   Esophageal Cancer;   Gastrointestinal Stromal Tumor (GIST)
Interventions: Procedure: Blood draw;   Procedure: Tissue tumor biopsy
15 Recruiting Vaccine Therapy in Treating Patients With Metastatic Solid Tumors
Conditions: Malignant Solid Tumour;   Breast Cancer;   Malignant Tumor of Colon;   GIST;   Ovarian Cancer
Interventions: Biological: HER-2 vaccine;   Biological: Extension HER-2 vaccine trial at OBD
16 Recruiting A Safety, Tolerability and PK Study of DCC-2618 in Patients With Advanced Malignancies
Conditions: Gastrointestinal Stromal Tumors;   Aggressive Systemic Mastocytosis;   Advanced Cancers
Intervention: Drug: DCC-2618
17 Recruiting Tyrosine Kinase Inhibition to Treat Myeloid Hypereosinophilic Syndrome
Condition: Hypereosinophilic Syndrome
Intervention: Drug: Imatinib Mesylate
18 Recruiting Ipilimumab and Imatinib Mesylate in Advanced Cancer
Condition: Advanced Cancers
Interventions: Drug: Ipilimumab;   Drug: Imatinib Mesylate
19 Recruiting TGR-1202 Alone and in Combination With Either Nab-paclitaxel + Gemcitabine or With FOLFOX in Patients With Select Relapsed or Refractory Solid Tumors
Conditions: Pancreatic Cancer;   Colorectal Cancer;   Rectal Cancer;   Gastric Cancer;   Esophageal Cancer;   Gastrointestinal Stromal Tumor (GIST)
Interventions: Drug: TGR-1202;   Drug: nab-paclitaxel + gemcitabine;   Drug: Oxaliplatin + Folinic acid + Fluorouracil;   Drug: Oxaliplatin + Folinic acid + Fluorouracil + Bevacizumab
20 Recruiting A Combination Clinical Study of PLX3397 and Pembrolizumab To Treat Advanced Melanoma and Other Solid Tumors
Conditions: Melanoma;   Non-small Cell Lung Cancer;   Squamous Cell Carcinoma of the Head and Neck;   Gastrointestinal Stromal Tumor (GIST);   Ovarian Cancer
Interventions: Drug: PLX3397;   Biological: Pembrolizumab

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Study has passed its completion date and status has not been verified in more than two years.