| 1 |
NCT02199509 |
Completed
Has Results |
Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia |
- Oromandibular Dystonia
- Cranial Dystonia
|
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Percent Change of the Sum of the Eyes, Mouth, Speech and Swallowing Subscores of the Burke-Fahn-Marsden (BFM) Dystonia Scale.
- Percent Change of the Sum of the Eyes, Mouth, Speech and Swallowing Subscores of Burke-Fahn-Marsten Dystonia Rating Scale (BFM)
- Percent Change of the Sum of Eyes and Upper Face, Lower Face and Jaw and Tongue Subscores of the GDS Rating Scale
|
8 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02199509 |
140152
14-N-0152 |
|
July 2014 |
March 2016 |
March 2016 |
July 24, 2014 |
July 11, 2017 |
July 11, 2017 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 2 |
NCT02107261 |
Recruiting |
Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand |
|
- Drug: incobotulinumtoxin A
|
Interventional
|
Phase 2 |
- Icahn School of Medicine at Mount Sinai
- Merz North America, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Patient and Physician Global Perception of change
- Quantitative MIDI Analysis comparison
- Blinded high speed video analysis comparison
- (and 2 more...)
|
20 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02107261 |
GCO 13-1679 |
|
March 2014 |
July 2019 |
July 2019 |
April 8, 2014 |
November 5, 2018 |
|
- NYU Langone Health
New York, New York, United States - Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
|
| 3 |
NCT00971854 |
Unknown † |
Alteration of Deep Brain Stimulation Parameters for Dystonia |
|
- Procedure: Alteration of deep brain stimulator settings
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To assess if the stimulation frequency of 60 Hz is superior to 130 Hz for patients with primary dystonia who have responded poorly to standard 130 Hz pallidal stimulation
- Assess any potential changes in anxiety, mood, cognition
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT00971854 |
09/H0603/11
R&D Study - 5898 |
|
September 2009 |
January 2010 |
February 2010 |
September 4, 2009 |
October 14, 2009 |
|
- University of Oxford, Nuffield Department of Surgery
Oxford, Oxfordshire, United Kingdom
|
|
| 4 |
NCT03664375 |
Completed |
Impact Of Physiotherapy And Botox In Improving Functional Outcomes Among Post Stroke Focal Dystonia Patients |
|
- Other: Botulinum toxin type A
- Other: Task Specific Training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Action Research Arm Test (ARAT):
- MOTOR ASSESSMENT SCALE (MAS)
- WOLF MOTOR FUNCTION TEST (WMFT)
- (and 3 more...)
|
39 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03664375 |
IIRS-IUISB/PHD/008 |
|
November 2015 |
August 2016 |
December 2016 |
September 10, 2018 |
September 10, 2018 |
|
|
|
| 5 |
NCT02468843 |
Completed |
Novel Stimulation Patterns for the Treatment of Dystonia |
- Dystonia
- Cervical Dystonia
|
- Device: Biphasic DBS stimulation
- Other: Unified Dystonia Rating Scale
- Other: Burke-Fahn- Marsden scale
|
Observational
|
|
- University of Florida
- Medtronic
|
Other / Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Blinded Unified Dystonia Rating Scale (UDRS)
- Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS)
- Tremor accelerometer to measure motor dysfunction
- (and 3 more...)
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02468843 |
IRB201500366 |
|
July 2015 |
January 2016 |
August 2016 |
June 11, 2015 |
October 27, 2016 |
|
- Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States
|
|
| 6 |
NCT01823237 |
Recruiting |
Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia |
|
- Device: Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Efficacy of TMS on task-specific focal hand dystonia
|
15 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01823237 |
IRB00062538
DYST |
|
February 2013 |
December 2019 |
April 2020 |
April 4, 2013 |
February 8, 2019 |
|
- Emory University School of Medicine
Atlanta, Georgia, United States
|
|
| 7 |
NCT03318120 |
Recruiting |
Exercise Training in Dystonia |
|
- Behavioral: Progressive Resistance Training
- Behavioral: Standardized Exercise Training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating Scale Score
- Burke-Fahn-Marsden Dystonia Rating Scale score
- Transcranial Magnetic Stimulation (TMS)
- (and 3 more...)
|
194 |
All |
30 Years to 80 Years (Adult, Older Adult) |
NCT03318120 |
IRB201702224
Pending |
|
November 6, 2017 |
December 1, 2020 |
December 1, 2020 |
October 23, 2017 |
October 15, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 8 |
NCT01761903 |
Active, not recruiting |
Functional Connectivity in Primary Focal Dystonia |
|
|
Observational
|
|
- University of Colorado, Denver
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Contrast between Primary Focal Dystonia (PFD) and Healthy Controls (HC)
- Correlation between basal ganglia motor network functional connectivity measures and total PFD clinical assessment scale scores
- Evaluation of Lateralization
- Statistical dependence between symptoms and measures of basal ganglia functional connectivity
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01761903 |
12-0289 |
|
May 2012 |
January 2019 |
September 2019 |
January 7, 2013 |
November 28, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States
|
|
| 9 |
NCT03017586 |
Recruiting |
Efficacy and Safety of DBS in Patients With Primary Dystonia |
|
- Device: Beijing Pins Medical Co., Ltd. Deep Brain Stimulator
|
Interventional
|
Not Applicable |
- Beijing Pins Medical Co., Ltd
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score
- Short-Form General Health Survey (SF-36)
- Visual analogue scale
- (and 4 more...)
|
70 |
All |
6 Years to 60 Years (Child, Adult) |
NCT03017586 |
PINS-023 |
|
December 27, 2017 |
September 2019 |
December 2019 |
January 11, 2017 |
March 15, 2018 |
|
- Beijing XieHe Hospital
Beijing, Beijing, China - Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
|
|
| 10 |
NCT01888926 |
Completed |
The Effects of Repetitive Paired Associative Stimulation in Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Change from baseline in the motor evoked potential (MEP) amplitude at S50 after 30 minutes from rPAS (T30).
|
19 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT01888926 |
130163
13-N-0163 |
|
June 18, 2013 |
August 2, 2016 |
August 2, 2016 |
June 28, 2013 |
February 14, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 11 |
NCT01671527 |
Completed |
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia |
|
- Procedure: Transcranial magnetic stimulation (TMS)
|
Observational
|
|
- University of Florida
- National Institutes of Health (NIH)
- Dystonia Coalition
|
Other / NIH |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- The body's response to transcranial magnetic stimulation (TMS)
- Clinical assessment of dystonia severity
|
29 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01671527 |
3142012
KL2TR000065 |
|
August 2012 |
March 2016 |
June 2016 |
August 23, 2012 |
June 13, 2016 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 12 |
NCT01738581 |
Completed
Has Results |
rTMS and Retraining in Focal Hand Dystonia |
|
- Device: Repetitive Transcranial Magnetic Stimulation
- Behavioral: Sensorimotor Retraining
- Behavioral: Non-specific Therapy
|
Interventional
|
Phase 1
Phase 2 |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change From Baseline in Global Rating of Change at Posttest (Day 5)
- Change From Baseline in Arm Dystonia Disability Scale at Posttest (Day 5)
- Change From Baseline in Sensation at Posttest (Day 5)
- (and 4 more...)
|
9 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT01738581 |
DSS0608M91226 |
DSS |
November 2011 |
June 2015 |
June 2015 |
November 30, 2012 |
February 20, 2017 |
June 28, 2016 |
- University of Minnesota, Program in Physical Therapy
Minneapolis, Minnesota, United States - Program in Physical Therapy, University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 13 |
NCT02686125 |
Recruiting |
Registry of Deep Brain Stimulation With the VERCISE™ System for Treatment of Dystonia: Vercise DBS Dystonia Registry |
|
- Device: Deep Brain Stimulation (DBS)
|
Observational
|
|
- Boston Scientific Corporation
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of subjects with reduction in dystonia symptoms as assessed by BFMDRS score
- Proportion of cervical dystonia subjects with reduction in symptoms as assessed by TWSTRS score
|
200 |
All |
7 Years and older (Child, Adult, Older Adult) |
NCT02686125 |
A4012 |
|
March 2016 |
December 2021 |
December 2024 |
February 19, 2016 |
January 16, 2019 |
|
- Boston Scientific Clinical Research Information
Valencia, California, United States
|
|
| 14 |
NCT01792336 |
Suspended |
Transcranial Magnetic Stimulation for Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Motor evoked potential following TMS conditioning versus the baseline MEP amplitude in dystonia patients and healthy subjects.
|
30 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT01792336 |
130076
13-N-0076 |
|
February 13, 2013 |
December 30, 2019 |
December 30, 2019 |
February 15, 2013 |
February 8, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 15 |
NCT00773604 |
Completed |
Deep Brain Stimulation in Patients With Dystonia |
|
- Device: Medtronic implantable deep brain stimulation (DBS) system
|
Interventional
|
Phase 1
Phase 2 |
- University of California, San Francisco
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary outcome measure is the change in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score from baseline to 12 months.
|
22 |
All |
7 Years to 80 Years (Child, Adult, Older Adult) |
NCT00773604 |
Private donor |
STN DBS |
June 2008 |
February 2015 |
February 2015 |
October 16, 2008 |
August 7, 2015 |
|
- San Francisco Veterans Administration Medical Center
San Francisco, California, United States - University of California, San Francisco
San Francisco, California, United States
|
|
| 16 |
NCT02583074 |
Recruiting |
Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia |
|
- Procedure: Stimulation
- Procedure: Sham-stimulation
|
Interventional
|
Not Applicable |
- Beijing Tiantan Hospital
- Peking Union Medical College Hospital
- The First Affiliated Hospital of Dalian Medical University
- China-Japan Friendship Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change of motor and disability scores
- Quality of life
- Depression
|
40 |
All |
Child, Adult, Older Adult |
NCT02583074 |
ZYLX201305 |
STN-CCD |
September 15, 2015 |
December 31, 2018 |
December 31, 2018 |
October 21, 2015 |
March 20, 2018 |
|
- Beijing Tiantan Hospital Affiliated to Capital Medical University
Beijing, Beijing, China - Beijing Tiantan Hospital Affiliated to Capital Medical University
Beijing, China
|
|
| 17 |
NCT01272154 |
Unknown † |
Cerebellum and Cortical Plasticity: the Case of Dystonia |
|
- Other: Transcranial magnetic stimulation
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
- Sree Chitra Tirunal Institute for Medical Sciences & Technology
- Policlinico G . Martino, Messina Italy
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Comparison of MEP0/MEP10 and MEP0/MEP30 values obtained after sham, cRTBS or iTBS of the cerebellum.
- Variation of the appropriate dystonic clinical score (depending on the type of dystonia) after each rTMS session (cTBS, iTBS, sham).
- Measurement of number of errors, mean time to reach the target after each rTMS session (cTBS, iTBS, sham).
- Measurement of the variation of the motor threshold, intracortical inhibition and intracortical facilitation after each rTMS session (cTBS, iTBS, sham).
|
120 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01272154 |
C10-01
2010-A00931-38 |
CERDYS |
January 2011 |
January 2013 |
January 2014 |
January 7, 2011 |
January 31, 2012 |
|
- Hpôpital Pitié Sapétrière - U 975 Plate forme " Pole Exploration de l'homme : Gait, Equilibrium, Posture, and Movement "
Paris, France
|
|
| 18 |
NCT02542839 |
Recruiting |
rTMS and Botulinum Toxin in Primary Cervical Dystonia |
- Primary Cervical Dystonia
- Dystonia
|
- Device: NeuroStar TMS therapy
- Device: Sham NeuroStar TMS therapy
- Other: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- (and 3 more...)
|
Interventional
|
Not Applicable |
- University of Florida
- American Brain Foundation
- Neuronetics
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Dystonia severity as assessed by the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- Physiological impact of TMS measured by Cerebellar Inhibition(CBI)
- Quality of life as assessed by Craniocervical Dystonia Questionnaire
|
35 |
All |
30 Years to 75 Years (Adult, Older Adult) |
NCT02542839 |
IRB201500341 |
|
November 2015 |
September 2019 |
September 2019 |
September 7, 2015 |
August 24, 2018 |
|
- UF Center for Movement Disorders & Neurorestoration
Gainesville, Florida, United States - UF Brain Institute
Gainesville, Florida, United States
|
|
| 19 |
NCT02046447 |
Completed |
Neuroimaging of Dystonia |
- Primary Cervical Dystonia
- DYT 1 Dystonia
|
- Drug: Primary Cervical Dystonia (Trihexyphenidyl)
- Other: Controls Primary Cervical Dystonia (Trihexyphenidyl)
- Other: DYT 1 Dystonia (Healthy Control)
- Other: DYT 1 Dystonia
|
Observational
|
|
- University of Florida
- Bachmann Strauss Dystonia & Parkinson Foundation, Inc.
|
Other / Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task
- Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task after administration of trihexyphenidyl compared to change in BOLD contrast during a precision gripping task
|
20 |
All |
7 Years to 70 Years (Child, Adult, Older Adult) |
NCT02046447 |
354-2013 |
NID |
May 2014 |
December 2015 |
December 2017 |
January 27, 2014 |
December 22, 2017 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 20 |
NCT03078816 |
Recruiting |
Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults |
|
- Device: Activa PC Primary Cell Neurostimulator - (Model 37601)
- Device: Activa RC Rechargeable Neurostimulator - (Model 37612)
- Device: Activa SC Single Cell Neurostimulator (Models 37602/37603)
- (and 6 more...)
|
Interventional
|
Phase 1 |
- University of California, San Francisco
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Adverse Events (AEs) and serious adverse events (SAEs)
- Burke-Fahn-Marsden Dystonia Rating Scale
- Pediatric Quality of Life Inventory (PedsQL)
- (and 8 more...)
|
15 |
All |
7 Years to 25 Years (Child, Adult) |
NCT03078816 |
123822A |
DBSVop |
March 3, 2017 |
May 2019 |
May 2019 |
March 13, 2017 |
May 2, 2017 |
|
- University of California San Francisco Hospital
San Francisco, California, United States
|
|
| 21 |
NCT00954408 |
Completed |
Fatigue in Dystonia (a Single Session, Questionnaire-based Study of Fatigue in Dystonia) |
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- To determine the prevalence of fatigue and sleepiness in patients with dystonia.
|
123 |
All |
21 Years and older (Adult, Older Adult) |
NCT00954408 |
108-2008 |
FID |
July 2009 |
July 2011 |
July 2011 |
August 7, 2009 |
September 19, 2011 |
|
- University of Florida Movement Disorders Center
Gainesville, Florida, United States
|
|
| 22 |
NCT03351218 |
Recruiting |
Agency in Dystonia |
|
- Behavioral: Behavioral testing - computerized tasks
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- agency tasks behavioral outcome measures
- MRI measures
|
100 |
All |
15 Years to 65 Years (Child, Adult, Older Adult) |
NCT03351218 |
C17-04
2017-A01231-52 |
AGENT10 |
October 23, 2017 |
October 23, 2019 |
December 23, 2019 |
November 22, 2017 |
November 22, 2017 |
|
- Centre d'investigation Clinique
Paris, Ile De France, France
|
|
| 23 |
NCT01460771 |
Unknown † |
Transcranial Direct-Current Stimulation in Childhood Dystonia |
- Childhood Onset Dystonias
|
- Device: TDCS (Transcranial Direct-current Stimulation)
- Device: sham TDCS (Transcranial Direct-current Stimulation)
|
Interventional
|
Phase 2 |
- University of Southern California
- National Institutes of Health (NIH)
- Crowley Carter Foundation
- Don and Linda Carter Foundation
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
100 |
All |
4 Years to 21 Years (Child, Adult) |
NCT01460771 |
TDCS2011 |
|
September 2011 |
September 2017 |
September 2017 |
October 27, 2011 |
May 22, 2014 |
|
- University of Southern California
Los Angeles, California, United States
|
|
| 24 |
NCT01433757 |
Completed |
Ampicillin for DYT-1 Dystonia Motor Symptoms |
|
- Drug: Ampicillin
- Drug: Sugar pill
|
Interventional
|
Phase 1 |
- University of Florida
- Tyler's Hope for a Dystonia Cure, Inc
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Safety and tolerability of Ampicillin in treating DYT-1 dystonia
- Burke-Fahn Marsden Dystonia Rating Scale (BFM-DRS)
|
2 |
All |
7 Years to 80 Years (Child, Adult, Older Adult) |
NCT01433757 |
301-2011 |
|
September 2011 |
June 2017 |
June 2017 |
September 14, 2011 |
July 5, 2017 |
|
- UF Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States
|
|
| 25 |
NCT00950664 |
Completed
Has Results |
A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia |
|
- Drug: Dysport® (abobotulinumtoxinA)
- Drug: Botox® (onabotulinumtoxinA)
|
Interventional
|
Phase 4 |
- Seoul National University Hospital
- Ipsen
- Medical Research Collaborating Center, Seoul, Korea
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction of Total Tsui Score at 4 Weeks From Baseline
- Reduction of Total TWSTRS Score at 4 Weeks From Baseline
- CGI-I (Clinical Global Impression of Illness)
- PGI-I (Patient's Global Impression of Improvement)
|
103 |
All |
20 Years to 80 Years (Adult, Older Adult) |
NCT00950664 |
H-0902-049-272 |
|
August 2009 |
January 2011 |
July 2011 |
August 3, 2009 |
July 5, 2017 |
October 11, 2013 |
- Bundang Seoul Natiuonal University Hospital
Seongnam, Gyeong-gi, Korea, Republic of - Dong-A University Hospital
Busan, Korea, Republic of - Hanyang University Hospital
Seoul, Korea, Republic of - (and 4 more...)
|
|
| 26 |
NCT00447772 |
Completed
Has Results |
Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia |
|
- Drug: Botulinum type A toxin (Dysport®)
|
Interventional
|
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change From Baseline in the Total Score of the Tsui Rating Scale (Patient in Sitting Position) at the First On-treatment Visit (Week 4 or Week 12)
- Change in the Total Score of the Tsui Rating Scale (Patient in Sitting Position) Between Visit 1 (Week 0) and Visit 3 (Week 12)
- Change in the Total Score of the Tsui Rating Scale (Patient Walking) Between Baseline (Week 0) and Visit 2 (Week 4) and Visit 3 (Week 12)
- (and 6 more...)
|
516 |
All |
18 Years and older (Adult, Older Adult) |
NCT00447772 |
A-94-52120-098 |
|
October 2004 |
February 2008 |
April 2008 |
March 15, 2007 |
January 14, 2019 |
July 30, 2018 |
- Krankenhaus der Barmherzigen Brüder
Graz, Austria - NÖ LKH Grimmenstein-Hochegg
Grimmenstein, Austria - Univ.-Klinik für Neurologie
Innsbruck, Austria - (and 103 more...)
|
|
| 27 |
NCT03481491 |
Not yet recruiting |
Interactions Between Striatum and Cerebellum in ADCY5 and PRRT2 Dystonias |
|
- Other: transcranial magnetic stimulation of the cerebellum
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Resting state functional connectivity between the cerebellum and the striatum
- Amplitude of Low Frequency Fluctuation (ALFF) of blood oxygen level-dependent signal in the cerebellum
- Fractional anisotropy (FA) of the cerebello-striatal tract
- (and 3 more...)
|
104 |
All |
183 Months and older (Child, Adult, Older Adult) |
NCT03481491 |
C16-128
2017-A01843-50 |
AMEDYST |
May 4, 2018 |
July 3, 2021 |
July 3, 2022 |
March 29, 2018 |
March 29, 2018 |
|
|
|
| 28 |
NCT03247868 |
Recruiting |
A Multimodal Approach to Cervical Dystonia Treatment With Association of Botulinum Toxin and Motor Learning Techniques |
- Cervical Dystonia,Primary
|
- Combination Product: Botulinum Toxin+SPRInt
|
Interventional
|
Not Applicable |
- Fondazione Don Carlo Gnocchi Onlus
|
Other |
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Dystonia phenomenology improvement
- quality of life
- brain plasticity
- (and 5 more...)
|
20 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03247868 |
SPRIntFdG |
SPRInt |
March 16, 2016 |
March 28, 2018 |
June 30, 2018 |
August 14, 2017 |
August 14, 2017 |
|
- IRCCS Fondazione Don Gnocchi
Milano, MI, Italy
|
|
| 29 |
NCT03587350 |
Completed |
Assessing Cervical Dystonia |
|
- Device: Shimmer monitoring
|
Interventional
|
Not Applicable |
- The Leeds Teaching Hospitals NHS Trust
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Successful monitoring of movement by the shimmer monitor
|
24 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03587350 |
NE16/88973 |
|
April 7, 2017 |
January 31, 2018 |
January 31, 2018 |
July 16, 2018 |
July 16, 2018 |
|
- Leeds Teaching Hospitals NHS Trust
Leeds, West Yorkshire, United Kingdom
|
|
| 30 |
NCT03805152 |
Not yet recruiting |
Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia |
|
- Drug: Neuronox(R)
- Drug: Dysport (R)
|
Interventional
|
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating scale ( TWSTRS)
- Cervical Dystonia Impact Profile 58 ( CDIP-58)
- Comparesion the quality of life 36 item ( SF 36)
- (and 3 more...)
|
50 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03805152 |
A-01-2019 |
DNCD |
January 13, 2019 |
July 31, 2020 |
August 31, 2020 |
January 15, 2019 |
January 15, 2019 |
|
|
|
| 31 |
NCT03409120 |
Enrolling by invitation |
Unlocking Dystonia From Parkinson's Disease With Directional DBS Technology |
- Dystonia-Parkinsonism, Adult-Onset
- Parkinson Disease
|
- Device: Boston Scientific Vercise PC IPG with directional DBS lead
|
Interventional
|
Not Applicable |
- University of Alabama at Birmingham
- Michael J. Fox Foundation for Parkinson's Research
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Burke-Fahn-Marsden Dystonia Rating Scale
|
30 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03409120 |
IRB-300001136 |
|
January 1, 2018 |
December 31, 2020 |
December 31, 2020 |
January 24, 2018 |
February 7, 2019 |
|
- University of Alabama at Birmingham
Birmingham, Alabama, United States
|
|
| 32 |
NCT03347240 |
Completed |
Neuroablation Versus Neuromodulation Techniques for Treatment of Secondary Dystonia |
|
- Procedure: Brain Lesioning
- Procedure: Combined anterior and posterior lumbosacral rhizotomy
- Device: Deep brain stimulation
- Device: Intra-thecal baclofen infusion
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Burke-Fahn-Marsden dystonia rating scale
- Modified Ashworth scale
- Barthel index
|
120 |
All |
3 Years to 50 Years (Child, Adult) |
NCT03347240 |
4996 |
|
December 1, 2013 |
December 31, 2016 |
December 31, 2016 |
November 20, 2017 |
November 20, 2017 |
|
|
|
| 33 |
NCT02180139 |
Withdrawn |
tDCS in Cervical Dystonia |
|
- Device: transcranial direct current stimulation
|
Interventional
|
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Cervical Dystonia Questionnaire (CDQ-24)
- Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- Visual Analog Scale (VAS)
- Cortical Excitability as measured by transcranial magnetic stimulation
|
0 |
All |
21 Years to 65 Years (Adult, Older Adult) |
NCT02180139 |
TDCS-2014 |
|
September 2017 |
September 2017 |
December 2017 |
July 2, 2014 |
October 3, 2017 |
|
- University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 34 |
NCT01373424 |
Recruiting |
The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias |
|
|
Observational
|
|
- Hyder A. Jinnah, MD, PhD
- National Institute of Neurological Disorders and Stroke (NINDS)
- Office of Rare Diseases (ORD)
- (and 3 more...)
|
Other / NIH / Industry |
- Observational Model: Other
- Time Perspective: Other
|
|
5000 |
All |
18 Years and older (Adult, Older Adult) |
NCT01373424 |
IRB00046266
U54TR001456
RDCRN#6301
U54NS065701 |
DCP |
January 2011 |
June 2020 |
August 2021 |
June 15, 2011 |
August 8, 2018 |
|
- University of Alabama, Birmingham
Birmingham, Alabama, United States - Mayo Clinic, Arizona
Scottsdale, Arizona, United States - Parkinson's and Movement Disorders Institute
Fountain Valley, California, United States - (and 39 more...)
|
|
| 35 |
NCT02959645 |
Recruiting |
Assessment of Brain Activities in Cervical Dystonia |
|
|
Observational
|
|
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Hand Joint Position Sense
- Brain Signals Recorded via Non-Invasive Surface Electromyography
|
40 |
All |
18 Years to 78 Years (Adult, Older Adult) |
NCT02959645 |
1607M91461 |
|
September 1, 2017 |
July 2020 |
July 2020 |
November 9, 2016 |
August 23, 2018 |
|
- Elliott Hall-MSP Lab
Minneapolis, Minnesota, United States
|
|
| 36 |
NCT00773253 |
Completed
Has Results |
Botox for Cervical Dystonia Following EMG Mapping |
|
|
Interventional
|
Phase 4 |
- University of California, San Francisco
- Allergan
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pre- and Post-injection Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS): Global Clinical Impression Scale (GCI); Visual Analog Scale(VAS)
- Mean Percentage Change in Total Toronto Western Spasmodic Torticollis Rating Scale
|
10 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00773253 |
Allergan cervical dystonia |
|
April 2008 |
October 2010 |
January 2011 |
October 16, 2008 |
October 13, 2011 |
October 13, 2011 |
- University of California, San Francisco
San Francisco, California, United States
|
|
| 37 |
NCT03363113 |
Completed |
Outcome of Botulinum Toxin Treatment for Oromandibular Dystonia |
|
|
Observational
|
|
- Fondation Ophtalmologique Adolphe de Rothschild
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Clinical improvement score
|
240 |
All |
18 Years and older (Adult, Older Adult) |
NCT03363113 |
CE_20150630_7_LSM |
rétroBODOM |
January 1, 2016 |
April 1, 2016 |
July 12, 2016 |
December 6, 2017 |
December 6, 2017 |
|
|
|
| 38 |
NCT03608397 |
Recruiting |
Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1) |
|
- Biological: DaxibotulinumtoxinA for injection
- Biological: Placebo
|
Interventional
|
Phase 3 |
- Revance Therapeutics, Inc.
- Syneos Health
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)-total score
- Change from Baseline TWSTRS-total score
- Duration of effect
- (and 2 more...)
|
301 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03608397 |
1720302 |
ASPEN-1 |
June 20, 2018 |
September 30, 2020 |
September 30, 2020 |
August 1, 2018 |
August 3, 2018 |
|
- HOPE Research Institute
Phoenix, Arizona, United States - Movement Disorders Center of Arizona
Scottsdale, Arizona, United States - The Parkinsons and Movement Disorder Institute
Fountain Valley, California, United States - (and 7 more...)
|
|
| 39 |
NCT03206112 |
Recruiting |
Loss of Depotentiation in Focal Dystonia |
- Focal Dystonia
- Healthy Volunteers
|
|
Interventional
|
Early Phase 1 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- MEP amplitude immediately after the PAS25-cTBS150 (depotentiation) protocol
- MEP amplitudes
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03206112 |
170123
17-N-0123 |
|
September 20, 2017 |
December 31, 2019 |
December 31, 2019 |
July 2, 2017 |
December 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 40 |
NCT02982304 |
Unknown † |
Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia |
- Dystonia
- Dystonia, Secondary
|
- Device: Deep Brain Stimulation
|
Interventional
|
Phase 1 |
- University of British Columbia
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Burke Fahn Marsden Disability Rating Scale (BFMDRS)
- SF-36 Quality of Life Scale
- Adverse effects of Vim or Vim + GPi Neuromodulation
|
4 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02982304 |
H14-03185 |
|
January 2015 |
December 2017 |
|
December 5, 2016 |
December 5, 2016 |
|
- Vancouver General Hospital
Vancouver, British Columbia, Canada
|
|
| 41 |
NCT02069548 |
Completed |
Analysis of Three-dimensional Movements of the Head in Cervical Dystonia |
|
|
Observational
|
|
- Fondation Ophtalmologique Adolphe de Rothschild
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Range of motion of the voluntary mobility of the cervical spine in the three spatial planes
- movements disorders in cervical dystonia
- head posture
- range of motion
|
63 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02069548 |
2013-A01400-45 |
STAC1 |
February 2014 |
April 2015 |
April 2015 |
February 24, 2014 |
October 24, 2016 |
|
- Fondation Ophtalmologique Adolphe de Rothschild
Paris, Ile de France, France
|
|
| 42 |
NCT01753349 |
Completed |
Phase IV-Cervical Dystonia-INTEREST IN CD2 |
|
- Drug: BoNT-A injections, 3-4 times yearly
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in subject's satisfaction using a 5-point Likert scale.
- Change from baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score and severity sub-scale.
- Change in tremor associated with CD using Tsui score
- (and 3 more...)
|
1050 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753349 |
Y-79-52120-166 |
INTEREST_INCD2 |
December 2012 |
September 2017 |
September 25, 2017 |
December 20, 2012 |
January 7, 2019 |
|
- Parkinson's and Movement Disorders Center of Maryland
Elkridge, Maryland, United States - Tufts Medical Center, Inc
Boston, Massachusetts, United States - The Parkinson's and Movement Disorders Center
Southfield, Michigan, United States - (and 110 more...)
|
|
| 43 |
NCT00004421 |
Completed |
Deep Brain Stimulation in Treating Patients With Dystonia |
|
- Device: implanted pulse generator
|
Interventional
|
Phase 2
Phase 3 |
- Icahn School of Medicine at Mount Sinai
- FDA Office of Orphan Products Development
|
Other |
- Primary Purpose: Treatment
|
|
15 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00004421 |
199/13315
MTS-FDR001452 |
|
September 1997 |
|
September 2000 |
October 19, 1999 |
March 25, 2015 |
|
- Mount Sinai Medical Center, NY
New York, New York, United States
|
|
| 44 |
NCT01180270 |
Completed |
Static Graviceptive Functions in Patients With Cervical Dystonia (CD) |
|
|
Observational
|
|
- Kirsten Elwischger
- Medical University of Vienna
|
Other |
- Time Perspective: Prospective
|
- Subjective visual vertical (SVV), measured in degree (°)
- SVV in degree (°)
- Degree of head deviation (°)
- degree of head deviation (°)
|
45 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01180270 |
SVV_CD1 |
|
June 2010 |
January 2012 |
January 2012 |
August 12, 2010 |
January 31, 2012 |
|
- Department of neurology, Medical University of Vienna
Vienna, Austria
|
|
| 45 |
NCT00580658 |
Approved for marketing |
Humanitarian Device Exemption |
|
- Device: Medtronic Activa Gpi
|
Expanded Access
|
|
|
Other |
|
|
|
All |
7 Years and older (Child, Adult, Older Adult) |
NCT00580658 |
060155 |
Dystonia IRB |
May 2006 |
|
May 2020 |
December 27, 2007 |
May 13, 2016 |
|
- Vanderbilt University
Nashville, Tennessee, United States
|
|
| 46 |
NCT02263417 |
Unknown † |
A Randomized Controlled Trail Comparing Subthalamic and Pallidal Deep Brain Stimulation for Dystonia |
|
- Device: Deep Brain Stimulation (DBS) of Gpi
- Device: Deep Brain Stimulation (DBS) of STN
|
Interventional
|
Early Phase 1 |
- Beijing Pins Medical Co., Ltd
- Peking Union Medical College Hospital
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Burke-Fahn-Marsden Scale (BFM)
- Quality of life (SF-36)
- Psychiatric assessment (HADS-D and PANSS)
|
40 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02263417 |
PINS-005 |
|
July 2015 |
December 2018 |
December 2018 |
October 13, 2014 |
October 11, 2016 |
|
- Peking union medical college hospital
Beijing, Beijing, China
|
|
| 47 |
NCT00015457 |
Completed
Has Results |
Amlodipine Plus Botulinum Toxin for Focal Dystonia |
|
- Drug: Amlodipine plus Botulinum toxin
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating Scale (TWSTR) Sum Score
- Duration of Response to Botulinum Toxin Injection With Amlodipine and With Placebo
|
16 |
All |
18 Years and older (Adult, Older Adult) |
NCT00015457 |
010147
01-N-0147 |
|
April 2001 |
April 2009 |
|
April 19, 2001 |
April 1, 2013 |
April 1, 2013 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 48 |
NCT00505323 |
Completed |
Motor and Premotor Cortex Stimulation for Treatment of Secondary Focal Dystonia With Striato Palliadal Lesion : Evaluation of Safety and Effectiveness |
|
- Device: Implantation of neurostimulators and their auxiliary components
|
Interventional
|
Phase 1 |
- University Hospital, Clermont-Ferrand
- Medtronic
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Evaluation of dystonia by using the validated "Burke Fahn and Marsden (1985)" dystonia rating scale
- Evaluation of spasticity (Ashworth), of akinesy (Tapping score), of pain (EVA test), of quality of life (SF 36 scale) and of undesirable events.
|
5 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00505323 |
2007-A00100-53
PHRC N 2007 DURIF |
CORDYS |
September 2007 |
June 2011 |
June 2011 |
July 23, 2007 |
July 8, 2014 |
|
|
|
| 49 |
NCT00760318 |
Terminated |
Keppra for Cervical Dystonia |
|
|
Interventional
|
Phase 2 |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Primary endpoint will be the difference in change in TWSTRS score from baseline to week 16.
- Secondary outcome measures will include difference in change in TWSTRS score from baseline to weeks 4, 8, 12, 16, 20, and 24 in patient-reported duration of benefit for their Botox injection, and length of time between injections.
|
17 |
All |
18 Years and older (Adult, Older Adult) |
NCT00760318 |
UCB Pharma- Keppra |
Keppra |
November 2005 |
October 2007 |
October 2007 |
September 26, 2008 |
November 22, 2018 |
|
|
|
| 50 |
NCT01806805 |
Completed |
Efficacy Trial of Zonisamide for Myoclonus Dystonia |
|
- Drug: zonegran
- Drug: placebo
|
Interventional
|
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Measure of the evolution of the severity of myoclonus by a specific scale (UMRS)
- Measure of the evolution of the severity of dystonia by a specific scale (BFM)
- measure of the evolution of the severity of myoclonus by electromyographic recording
|
24 |
All |
18 Years to 60 Years (Adult) |
NCT01806805 |
P091104 |
EpsilonZêta |
February 2012 |
July 2014 |
July 2014 |
March 7, 2013 |
April 24, 2015 |
|
- Pitié salpetriere hospital
Paris, France
|
|
| 51 |
NCT00105430 |
Completed |
Deep Brain Stimulation for Cervical Dystonia |
- Dystonia
- Generalized Primary Dystonia
|
- Procedure: Deep Brain Stimulation
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
- Clinical effectiveness of DBS of the Gpi or STN will be measured by the Burke-Fahn-Marsden Scale (BFM) and monitored over time to determine the effectiveness DBS and if there is an ideal anatomic stimulation site.@@@@@@@@@
- Determine the underlying pathophysiology of dystonia, and the mechanism of action of DBS.
|
40 |
All |
7 Years to 70 Years (Child, Adult, Older Adult) |
NCT00105430 |
050111
05-N-0111 |
|
March 2005 |
|
July 2006 |
March 14, 2005 |
July 6, 2006 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 52 |
NCT02420106 |
Recruiting |
Effect of Osteopathic Manipulative Medicine on Motor Function and Quality of Life in Cervical Dystonia |
|
- Procedure: Osteopathic Manipulative Medicine
|
Interventional
|
Not Applicable |
- New York Institute of Technology
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Motor Function
- Change in Quality of Life
|
50 |
All |
2 Years to 100 Years (Child, Adult, Older Adult) |
NCT02420106 |
BHS-983 |
|
February 2014 |
August 2018 |
August 2018 |
April 17, 2015 |
October 10, 2017 |
|
- New York Institute of Technology
Old Westbury, New York, United States
|
|
| 53 |
NCT00102999 |
Completed |
Brain Function in Focal Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
118 |
All |
18 Years and older (Adult, Older Adult) |
NCT00102999 |
050094
05-N-0094 |
|
January 31, 2005 |
|
January 22, 2009 |
February 7, 2005 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 54 |
NCT00132990 |
Unknown † |
A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia |
|
- Device: Deep brain stimulation
|
Interventional
|
Not Applicable |
- University of Calgary
- Canadian Institutes of Health Research (CIHR)
- Calgary Health Region
- Medtronic
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: Single
- Primary Purpose: Treatment
|
- Improvement in neck postures/movements
- Improvement in quality of life
- Document adverse effects of surgery
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00132990 |
16760 |
|
February 2003 |
|
September 2005 |
August 22, 2005 |
January 12, 2007 |
|
- Dr. Zelma Kiss
Calgary, Alberta, Canada - Dr. Matt Wheatley
Edmonton, Alberta, Canada - Dr. Chris Honey
Vancouver, British Columbia, Canada - (and 2 more...)
|
|
| 55 |
NCT00082615 |
Completed |
Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
210 |
All |
18 Years and older (Adult, Older Adult) |
NCT00082615 |
040188
04-N-0188 |
|
May 11, 2004 |
|
April 21, 2008 |
May 13, 2004 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 56 |
NCT03369613 |
Recruiting |
Transcranial Electrical Stimulation for Cervical Dystonia |
- Primary Cervical Dystonia
|
- Device: transcranial electrical stimulation
|
Interventional
|
Not Applicable |
- University of Colorado, Denver
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Phase I: A change in brain functional connectivity in primary cervical dystonia
- Phase II: Improvement in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score
|
55 |
All |
18 Years and older (Adult, Older Adult) |
NCT03369613 |
17-1322 |
|
October 27, 2017 |
December 2019 |
December 2019 |
December 12, 2017 |
December 27, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States
|
|
| 57 |
NCT00323765 |
Completed |
Plasticity in Cervical Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
44 |
All |
18 Years and older (Adult, Older Adult) |
NCT00323765 |
060157
06-N-0157 |
|
May 5, 2006 |
|
May 20, 2008 |
May 10, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 58 |
NCT02662530 |
Recruiting |
Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia |
|
- Drug: Botulinum Toxin Type A
|
Interventional
|
Phase 2 |
- Western University, Canada
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Number of participants with significant relief of severity and pain by TWSTRS part A and C, respectively, over treatment course
- Number of participants with significant relief of severity by objective kinematic reductions in angular deviation and amplitude measures over treatment course
- Number of participants with significant improvement in functional disability scores assessed by TWSTRS part B and patient-reported scores pre- and post-BoNT-A parameters determined visually or kinematically.
- Number of participants with significant relief of severity by global impression of change scores over treatment course
|
50 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02662530 |
105515 |
|
January 2012 |
June 2016 |
January 2020 |
January 25, 2016 |
February 20, 2018 |
|
- London Health Sciences Centre
London, Ontario, Canada
|
|
| 59 |
NCT03381456 |
Completed |
Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia |
|
|
Interventional
|
Not Applicable |
- University Hospital, Lille
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- long-interval intracortical inhibition (LICI) level
|
20 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03381456 |
2013_51
2014-A00244-43 |
LICIdystonie |
April 2015 |
April 2017 |
April 2017 |
December 22, 2017 |
December 22, 2017 |
|
- Hôpital Roger Salengro, CHRU de Lille
Lille, France
|
|
| 60 |
NCT02131467 |
Recruiting |
Safety and Tolerability of Perampanel in Cervical Dystonia |
|
|
Interventional
|
Phase 1
Phase 2 |
- University Health Network, Toronto
- Dystonia Study Group
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of subjects able to remain on study drug for minimum of 4 weeks.
- Safety will be evaluated as the cumulative number of new adverse events collected at each visit from Baseline to visit 4
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02131467 |
17-5864.4 |
SAFE-PER-CD |
September 1, 2017 |
January 2020 |
January 2020 |
May 6, 2014 |
February 4, 2019 |
|
- Emory University School of Medicine
Atlanta, Georgia, United States - Rush University Medical Center
Chicago, Illinois, United States - Beth Israel Medical Center
New York, New York, United States - (and 2 more...)
|
|
| 61 |
NCT00310414 |
Completed |
fMRI Studies of Task Specificity in Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
51 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00310414 |
060128
06-N-0128 |
|
March 30, 2006 |
|
March 13, 2012 |
April 3, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 62 |
NCT00309010 |
Completed |
Neurophysiology of Task-Specificity of Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
115 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00309010 |
060126
06-N-0126 |
|
March 28, 2006 |
|
February 24, 2009 |
March 30, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 63 |
NCT02911103 |
Recruiting |
Deep Brain Stimulation Surgery for Focal Hand Dystonia |
- Dystonia
- Focal Dystonia
- Musician's Dystonia
|
|
Interventional
|
Phase 1
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number and severity of adverse events
- Dystonia disability score
- FHD severity score
- (and 4 more...)
|
15 |
All |
22 Years to 100 Years (Adult, Older Adult) |
NCT02911103 |
160166
16-N-0166 |
|
September 21, 2016 |
September 1, 2020 |
September 30, 2020 |
September 22, 2016 |
November 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 64 |
NCT00021853 |
Completed |
Motor Training to Treat Hand Dystonia |
|
- Behavioral: constraint-induced movement therapy
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
15 |
All |
Child, Adult, Older Adult |
NCT00021853 |
010217
01-N-0217 |
|
August 2001 |
|
August 2002 |
August 9, 2001 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 65 |
NCT02618889 |
Completed |
OnabotulinumtoxinA in the Management of Psychogenic Dystonia |
|
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Rating Scale for Psychogenic Movement Disorders (RSPMD)
- Clinical Global Impression (CGI) of change
- Hamilton Depression Rating Scale (HAM-D)
- Hamilton Anxiety Rating Scale (HAM-A)
|
18 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02618889 |
2015-4496 |
|
January 15, 2016 |
May 30, 2017 |
June 30, 2017 |
December 2, 2015 |
November 30, 2018 |
|
- Alberto Espay
Cincinnati, Ohio, United States
|
|
| 66 |
NCT00306865 |
Completed |
Brain Changes in Patients With Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00306865 |
060031
06-N-0031 |
|
March 17, 2006 |
|
October 14, 2010 |
March 24, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 67 |
NCT00025701 |
Completed |
EEG and EMG Studies of Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
75 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00025701 |
020010
02-N-0010 |
|
October 9, 2001 |
|
October 4, 2010 |
October 12, 2001 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 68 |
NCT00054652 |
Completed |
Survey of Sensory and Motor Tricks in Focal Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
80 |
All |
Child, Adult, Older Adult |
NCT00054652 |
030089
03-N-0089 |
|
February 2003 |
|
February 2005 |
February 6, 2003 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 69 |
NCT01373840 |
Completed |
Role of Dopamine Receptors in Primary Focal Dystonias |
|
|
Observational
|
|
- Washington University School of Medicine
- National Institute of Neurological Disorders and Stroke (NINDS)
|
Other / NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
40 |
All |
21 Years and older (Adult, Older Adult) |
NCT01373840 |
201102481 |
|
September 2011 |
April 2016 |
April 2016 |
June 15, 2011 |
May 15, 2018 |
|
- Washington University
Saint Louis, Missouri, United States
|
|
| 70 |
NCT00702754 |
Completed
Has Results |
An Open Label Safety and Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) Injectable Solution in Patients With Cervical Dystonia |
|
- Biological: Botulinum Toxin Type B
|
Interventional
|
Phase 4 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Treatment Assessment Scale (TAS), 4 Wks Post-injection Compared to Baseline (Time 0), Rating of Cervical Dystonia Symptoms
- Treatment Assessment Scale (TAS), Approx Wk 12 + 4 Wks Post-Injection Compared to Baseline. Rating of Cervical Dystonia Symptoms
- Treatment Assessment Scale (TAS), Approx Wk 24 + 4 Wks Post-injection Compared to Baseline. Rating of Cervical Dystonia Symptoms
- (and 5 more...)
|
502 |
All |
18 Years and older (Adult, Older Adult) |
NCT00702754 |
401CDNA |
|
June 2001 |
May 2008 |
September 2008 |
June 20, 2008 |
October 2, 2009 |
September 23, 2009 |
|
|
| 71 |
NCT02877836 |
Recruiting |
Functional MRI and DTI in the Preoperative Assessment of Dystonia |
- Isolated Cervical Dystonia
- Complex Dystonia
- Spasticity
|
- Other: magnetic resonance imaging (fMRI)
|
Interventional
|
Not Applicable |
- University Hospital, Montpellier
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Integrity of Motor circuit reorganization in dystonia
- Integrity of corticospinal tract white matter in dystonia
- Movement-related fMRI activation pattern in dystonic patients
|
40 |
All |
18 Years to 84 Years (Adult, Older Adult) |
NCT02877836 |
9095 |
IRMF-DIFF |
September 2014 |
August 2018 |
September 2018 |
August 24, 2016 |
May 21, 2018 |
|
- CHU de Montpellier
Montpellier, France
|
|
| 72 |
NCT00325091 |
Completed |
Long-Term Motor Learning in Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
19 |
All |
18 Years and older (Adult, Older Adult) |
NCT00325091 |
060161
06-N-0161 |
|
May 9, 2006 |
|
January 6, 2014 |
May 12, 2006 |
February 15, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 73 |
NCT00376753 |
Completed |
Muscle Contraction in Patients With Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
84 |
All |
18 Years and older (Adult, Older Adult) |
NCT00376753 |
060242
06-N-0242 |
|
September 11, 2006 |
|
May 11, 2011 |
September 15, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 74 |
NCT01753310 |
Completed
Has Results |
Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia. |
|
- Drug: Dysport®
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Total Score at Week 4.
- Change From Baseline in TWSTRS Total Score at Week 2.
- Change From Baseline in Clinical Global Impression of Change (CGIC) in CD at Week 2.
- (and 5 more...)
|
134 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753310 |
A-TL-52120-169 |
|
January 2013 |
October 2014 |
January 2015 |
December 20, 2012 |
March 16, 2017 |
March 16, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Movement Disorders Center of Arizona, LLC
Scottsdale, Arizona, United States - University of Arizona
Tucson, Arizona, United States - (and 39 more...)
|
|
| 75 |
NCT03223623 |
Recruiting |
Pathophysiology of Dystonia and Complex Regional Pain Syndrome |
- Dystonia
- Complex Regional Pain Syndromes
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- The evaluation using fMRI will be performed under 3 conditions; 1. Rest 2. Voluntary activity 3. Motor imagery task.
- TMS outcomes (continuous): differential influences of PMv and IPL on motor cortical excitability, changes after cTBS of dIPL, changes in the SI measures post TBS in FHD.
|
60 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03223623 |
170126
17-N-0126 |
|
December 12, 2017 |
December 31, 2019 |
December 31, 2019 |
July 21, 2017 |
February 15, 2019 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 76 |
NCT01314365 |
Completed |
DYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical Dystonia |
|
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of treatment responders using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) severity scale score
- Patient Global Impression of Change using the 7-point Likert scale
- Clinical Global Impression of Change using the 7-point Likert scale
- (and 4 more...)
|
350 |
All |
18 Years and older (Adult, Older Adult) |
NCT01314365 |
A-TL-52120-156 |
ANCHOR-CD |
April 2011 |
November 2013 |
March 2014 |
March 14, 2011 |
April 30, 2014 |
|
- Arizona Dystonia Institute
Scottsdale, Arizona, United States - East Bay Physicians Medical Group
Berkeley, California, United States - Headache Center
Encinitas, California, United States - (and 42 more...)
|
|
| 77 |
NCT01287247 |
Completed |
Trial Evaluating Xeomin® (incobotulinumtoxinA) for Cervical Dystonia or Blepharospasm in the United States |
- Cervical Dystonia
- Blepharospasm
|
|
Observational
|
|
- Merz North America, Inc.
- Registrat-Mapi
|
Industry / Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Determination of injection patterns and techniques
- To collect and evaluate efficacy of Xeomin®(incobotulinumtoxinA) including onset and offset of effect as well as improvement of disease specific and global illness severity
|
688 |
All |
18 Years and older (Adult, Older Adult) |
NCT01287247 |
MRZ 60201-4066-5 |
XCiDaBLE |
February 2011 |
April 2013 |
April 2013 |
February 1, 2011 |
April 10, 2015 |
|
- Site #001052
Cullman, Alabama, United States - Scottsdale, Arizona, United States
- Site # 001974
Tucson, Arizona, United States - (and 67 more...)
|
|
| 78 |
NCT00132340 |
Completed |
Deep Brain Stimulation to Treat Cervical Dystonia |
|
|
Interventional
|
Phase 1 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT00132340 |
050222
05-N-0222 |
|
August 2005 |
|
July 2006 |
August 19, 2005 |
July 6, 2006 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 79 |
NCT00142259 |
Unknown † |
Efficacy and Safety of DBS of the GPi in Patients With Primary Generalized and Segmental Dystonia |
|
- Device: Deep brain stimulation of the internal globus pallidus
|
Interventional
|
Phase 4 |
- German Parkinson Study Group (GPS)
- Medtronic
- Competence Network on Parkinson's Disease
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- relative change of the individual Burk-Fahn-Marsden-Dystonia motor score 3 months after treatment compared to baseline
- relative change of the individual Burk-Fahn-Marsden-Dystonia ADL score 3 months after treatment compared to baseline
|
40 |
All |
14 Years to 75 Years (Child, Adult, Older Adult) |
NCT00142259 |
15
Grant: 01 GI 0201 / 01 GI 0401 |
|
October 2002 |
|
August 2009 |
September 2, 2005 |
December 6, 2006 |
|
- Medical University Innsbruck, Department of Neurology
Innsbruck, Tyrol, Austria - Klinikum der LMU, Neurologische Klinik
München, Bayern, Germany - Neurologische Klinik am Klinikum der BJM-Universität
Würzburg, Bayern, Germany - (and 5 more...)
|
|
| 80 |
NCT00418925 |
Unknown † |
Efficacy of Dronabinol for the Treatment of Cervical Dystonia |
|
|
Interventional
|
Phase 2 |
- University Health Network, Toronto
- Dystonia Medical Research Foundation
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)with 3 weeks of active treatment compared to placebo
- To determine the rate and severity of adverse events within and between participants
- To observe changes within and between participants in the Global Impression Scale (GIS)
- To observe changes within and between participants in the Visual Analog Pain Scale
|
38 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00418925 |
MDC DRO 2006 |
|
September 2006 |
November 2009 |
December 2009 |
January 5, 2007 |
September 9, 2008 |
|
- Toronto Western Hospital
Toronto, Ontario, Canada
|
|
| 81 |
NCT02509338 |
Terminated |
Validation of the Implantation of a New Electrode for the Treatment of Dystonia |
- Generalized Dystonia
- Segmental Dystonia
- Tardive Dystonia
|
- Device: Electrode deep brain stimulation (Monopolar DBS Lead Model 09064-40cm)
|
Interventional
|
Not Applicable |
- University Hospital, Montpellier
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Technical feasibility of new electrode implantation
- Safety of new electrode implantation (evaluated by the occurence of side effects)
- clinical effect of deep brain stimulation using one contact-electrodes (Burke Fahn Marsden's dystonia rating scale and the Toronto Western Spasmodic Torticollis Rating Scale)
|
7 |
All |
18 Years to 64 Years (Adult) |
NCT02509338 |
9053 |
MONOCONTACT |
October 2013 |
December 2016 |
December 2016 |
July 28, 2015 |
May 22, 2018 |
|
- Chru Montpellier
Montpellier, France
|
|
| 82 |
NCT03232320 |
Recruiting |
Meditoxin® Treatment in Patients With Cervical Dystonia |
- Dystonia
- Dystonic Disorder
|
- Drug: Meditoxin
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Toronto Western Spasmodic Torticollis Rating Scale Total Score From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Severity Subscale as a change From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Disability Subscale as a change From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Pain Subscale as a change From Baseline
|
66 |
All |
20 Years to 75 Years (Adult, Older Adult) |
NCT03232320 |
MT01-KR16CVD309 |
|
July 6, 2017 |
October 31, 2019 |
December 31, 2019 |
July 27, 2017 |
August 9, 2017 |
|
- Asan Medical Center
Seoul, Korea, Republic of
|
|
| 83 |
NCT02470325 |
Unknown † |
The Effects of Cannabis on Dystonia and Spasticity on Pediatric Patients |
|
- Drug: Avidekel oil
- Drug: Enriched Avidekel oil
|
Interventional
|
Phase 2 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Investigator)
- Primary Purpose: Treatment
|
- Changing in Spasticity and Dystonia grades using Modified Ashworth Scale, Barry Albright Dystonia Scale and Patient's subjective report
- Quality Of Life Scores on the Visual Analog Scale and CPCHILD questionnaire
- Number of Participants with Adverse Events as a Measure of Safety and Tolerability
- Comparing the scores receive from the different scales in both groups to determine the most effective cannabis oil - a ratio of 1 to 6 or 1 to 20 of Δ9 -THC to CBD.
|
40 |
All |
1 Year to 18 Years (Child, Adult) |
NCT02470325 |
0101-14-WOMC |
|
July 2015 |
December 2016 |
December 2017 |
June 12, 2015 |
August 18, 2015 |
|
- Dr. Lubov Blumkin
Holon, Israel
|
|
| 84 |
NCT00909883 |
Unknown † |
Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles) |
- Parkinson's Disease
- Foot Dystonia
|
- Drug: Botulinum Toxin: Xeomin
- Drug: Placebo
|
Interventional
|
Phase 3 |
- University Hospital, Clermont-Ferrand
- Merz Pharmaceuticals
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- In a controlled double blind and randomized study, we want to show that intramuscular injections of botulinum toxin are beneficial to reduced dystonia and associated pain in patient with foot dystonia (compared to placebo injections).
- Efficiency comparison of injections made in leg muscle (Flexor digitorum longus) between injections made directly in foot muscle (Flexor digitorum brevis or quadratus plantae) - Effects of injections on pain and quality of life.
|
45 |
All |
30 Years to 75 Years (Adult, Older Adult) |
NCT00909883 |
CHU-0051 |
RBHP 2008 |
September 2009 |
September 2011 |
September 2012 |
May 29, 2009 |
March 25, 2011 |
|
- CHU Gabriel-Montpied
Clermont-Ferrand, France - Hôpital La Pitié Salpétrière
Paris, France - Hôpital Haut-Levêque
Pessac, France - CHU Purpan
Toulouse, France
|
|
| 85 |
NCT00148889 |
Completed |
Double-blind, Multicenter Study to Assess the Efficacy of Bilateral Pallidal Stimulation in Patients With Medically Refractory Primary Cervical Dystonia |
|
- Device: Deep brain stimulation (DBS)
|
Interventional
|
Phase 3 |
- German Parkinson Study Group (GPS)
- Medtronic
- Competence Network on Parkinson's Disease
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Scale (TWSTRS) at 3 months following surgery (comparison between placebo and control group)
- side-effects, quality of life, depression, pain, long-term efficacy
|
63 |
All |
18 Years and older (Adult, Older Adult) |
NCT00148889 |
CD-DBS-2005-JM |
|
July 2005 |
April 2008 |
April 2008 |
September 8, 2005 |
February 16, 2018 |
|
- Medical University Innsbruck, Department of Neurology
Innsbruck, Tyrol, Austria - Department of Neurosurgery, Medical University Vienna
Vienna, Austria - Department of Neurology, Charité, Humboldt-University Berlin
Berlin, Germany - (and 7 more...)
|
|
| 86 |
NCT01753336 |
Completed
Has Results |
Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia |
|
|
Interventional
|
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- TWSTRS Total Score at Week 4 and Week 12 for Treatment Cycles 1, 2 and 3.
- TWSTRS Total Scores at Pretreatment Baseline, Week 4 and Week 12 for Treatment Cycles 1, 2 and 3.
- Treatment Response in Treatment Cycle 3 Week 4.
- (and 3 more...)
|
112 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753336 |
A-TL-52120-170 |
|
March 2013 |
October 2015 |
October 2015 |
December 20, 2012 |
May 4, 2017 |
May 4, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Movement Disorders Center of Arizona, LLC
Scottsdale, Arizona, United States - University of Arizona
Tucson, Arizona, United States - (and 38 more...)
|
|
| 87 |
NCT03042962 |
Enrolling by invitation |
Brain Networks in Dystonia |
- Spasmodic Dysphonia
- Singer's Dystonia
- Writer's Cramp
- Musician's Focal Hand Dystonia
|
- Other: MRI
- Procedure: Blood draw
|
Observational
|
|
- Kristina Simonyan
- National Institute of Neurological Disorders and Stroke (NINDS)
- Massachusetts Eye and Ear Infirmary
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Incidence of brain structural and functional changes
|
140 |
All |
21 Years to 80 Years (Adult, Older Adult) |
NCT03042962 |
17-064H
R01NS088160 |
|
August 1, 2015 |
May 31, 2020 |
May 31, 2020 |
February 3, 2017 |
January 8, 2019 |
|
- Massachusetts Eye and Ear Infirmary
Boston, Massachusetts, United States
|
|
| 88 |
NCT01884064 |
Completed
Has Results |
Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand Dystonia |
- Dystonia, Focal, Task-specific
|
- Device: rTMS
- Device: Sham rTMS
|
Interventional
|
Phase 1 |
- University of Minnesota - Clinical and Translational Science Institute
- Dystonia Medical Research Foundation
- National Institutes of Health (NIH)
- National Center for Research Resources (NCRR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
17 |
All |
21 Years to 75 Years (Adult, Older Adult) |
NCT01884064 |
0608M91226
M01RR000400 |
|
July 2008 |
July 2010 |
July 2010 |
June 21, 2013 |
June 17, 2016 |
November 2, 2015 |
- Program in Physical Therapy, University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 89 |
NCT01840462 |
Completed |
Longitudinal Study for Treatment With Botulinum Toxin A Injections in naïve and Pre-treated Patients Suffering From Cervical Dystonia [CD-NIS-Longterm] |
|
|
Observational
|
|
|
Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
372 |
All |
18 Years and older (Adult, Older Adult) |
NCT01840462 |
A-94-52120-165 |
CDNISLongterm |
July 2012 |
November 2015 |
March 2016 |
April 25, 2013 |
January 14, 2019 |
|
- Graz, Austria
- Wiesbaden, Germany
|
|
| 90 |
NCT00703287 |
Completed |
Specialized Physiotherapy Program for Cervical Dystonia |
|
|
Interventional
|
Not Applicable |
- Dr Donald Grosset
- University of Aberdeen
- South Glasgow University Hospitals NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To compare different types of physiotherapy for treating condition
|
110 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT00703287 |
SN07NE039 |
|
January 2008 |
May 2010 |
December 2010 |
June 23, 2008 |
February 4, 2013 |
|
- Southern General Hospital, 1345 Govan Road
Glasgow, Scotland, United Kingdom
|
|
| 91 |
NCT03617367 |
Recruiting |
Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS) |
|
- Biological: daxibotulinumtoxinA for injection
|
Interventional
|
Phase 3 |
- Revance Therapeutics, Inc.
- Syneos Health
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Long Term Safety of patients determined by the incidence of treatment-emergent adverse events
- The proportion of subjects with at least moderate improvement on the Clinician Global Impression of Change (CGIC) at Weeks 4 or 6 for Treatment Cycles 1, 2, 3, and 4
- The average of the change from Baseline in the TWSTRS Total Score at Weeks 4 and 6 for Treatment Cycles 1, 2, 3, and 4 [Time Frame: Weeks 4 and 6 of treatment cycles 1, 2, 3, and 4 (12 - 52 weeks duration each)]
|
350 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03617367 |
1720304 |
ASPEN-OLS |
September 5, 2018 |
November 30, 2021 |
November 30, 2021 |
August 6, 2018 |
September 20, 2018 |
|
- Kansas Institute of Reseach
Overland Park, Kansas, United States
|
|
| 92 |
NCT01859247 |
Completed
Has Results |
Identification of Optimal Stimulation Site for Cervical Dystonia Symptoms: An Exploratory Study |
- Cervical Dystonia
- Spasmodic Torticollis
|
|
Interventional
|
Not Applicable |
- University of New Mexico
- Dystonia Coalition
- National Institutes of Health (NIH)
- (and 2 more...)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- Dorsal Premotor-motor Inhibition (dPMI)
- Composite Measure of Patient Rating of Symptoms and Tolerability
|
8 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT01859247 |
UNM 657
U54NS065701 |
|
March 2013 |
June 2014 |
June 2014 |
May 21, 2013 |
July 28, 2016 |
July 28, 2016 |
- University of New Mexico
Albuquerque, New Mexico, United States
|
|
| 93 |
NCT02106936 |
Terminated |
Depotentiation in People With Focal Hand Dystonia |
- Focal Dystonia
- Healthy Volunteers
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- Prachaya Srivanitchapoom, MD
- National Institutes of Health Clinical Center (CC)
|
NIH / Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Motor evoked potential amplitude
|
6 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02106936 |
140070
14-N-0070 |
|
March 5, 2014 |
June 20, 2017 |
June 20, 2017 |
April 8, 2014 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 94 |
NCT01261611 |
Completed |
Study Comparing Short Term Efficacy of Dysport® and Dysport RU® to Placebo, and to Assess Efficacy and Safety of Dysport RU® of Subjects With Cervical Dystonia |
|
- Drug: Botulinum type A toxin (Dysport RU®)
- Drug: Botulinum type A toxin (Dysport®)
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score following first treatment
- Change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) severity score following first treatment
- Change in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) disability score following first treatment
- (and 10 more...)
|
333 |
All |
18 Years and older (Adult, Older Adult) |
NCT01261611 |
Y-52-52120-134
2010-019907-43 |
|
April 2011 |
May 2012 |
May 2013 |
December 16, 2010 |
February 28, 2014 |
|
- Monash Medical Centre
Clayton, Australia - Austin Hospital
Heidelberg, Australia - Department of Neurosciences Alfred Hospital
Prahran, Australia - (and 54 more...)
|
|
| 95 |
NCT00106782 |
Completed |
Transcranial Electrical Polarization to Treat Focal Hand Dystonia |
- Dystonia
- Focal Hand Dystonia
- FHD
|
- Procedure: Transcranial Electrical Polarization (TEP)
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- The Fahn Dystonia Scale before and after real and placebo TEP course.
|
12 |
All |
18 Years and older (Adult, Older Adult) |
NCT00106782 |
050122
05-N-0122 |
|
March 18, 2005 |
May 14, 2010 |
May 14, 2010 |
March 30, 2005 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 96 |
NCT01056861 |
Completed |
Effects of Botulinum Toxin in Cervical Dystonia |
- Torticollis
- Cervical Dystonia
|
|
Observational
|
|
- Henry Ford Health System
- Allergan
|
Other / Industry |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- Evidence of Cortical organizational changes with botulinum toxin treatment in patients with torticollis utilizing magnetoencephalography
- Tsui Torticollis Rating scale
|
7 |
All |
18 Years to 90 Years (Adult, Older Adult) |
NCT01056861 |
5307
08-0124 |
|
January 2010 |
July 2014 |
July 2014 |
January 26, 2010 |
April 17, 2015 |
|
- Henry Ford Hospital
Detroit, Michigan, United States
|
|
| 97 |
NCT02074293 |
Unknown † |
ASIS for Botox in Cervical Dystonia |
- Cervical Dystonia Adults ,
- Abnormal Head Position and Neck Pain for These 7 Muscle Groups: Splenius,Scalene,Sterno-cleido-mastoid,Levator Scapulae,Semispinalis,Trapezius,and Longissimus.
|
- Drug: Gadolinium
- Drug: Efficacy of Botox intramuscularly at Week 6
- Drug: Efficacy of Botox intramuscularly at Week 12
- (and 10 more...)
|
Interventional
|
Phase 1
Phase 2 |
- li nguyen
- ASIS Corporation
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Relative Prolongation Ability Score for Gadolinium subdermally injected.
- Efficacy of Botox intramuscularly vs. subdermally in Cervical Dystonia.
|
60 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02074293 |
NCTNS089268
R44NS089268 |
ASISinCD |
January 2016 |
June 2016 |
June 2017 |
February 28, 2014 |
June 24, 2015 |
|
- Automatic Subdermal Injector System, Inc
Westminster, California, United States
|
|
| 98 |
NCT01486264 |
Completed |
Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex |
|
|
Interventional
|
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Efficacy of the Short Flex dosing of Xeomin® compared to the Long Flex dosing regimen of Xeomin®,
|
286 |
All |
18 Years to 81 Years (Adult, Older Adult) |
NCT01486264 |
MUS 60201 4073 1 |
|
December 1, 2011 |
March 2016 |
February 28, 2017 |
December 6, 2011 |
April 27, 2017 |
|
- Merz Investigative Site #001234
Birmingham, Alabama, United States - Merz Investigative Site 001017
Fountain Valley, California, United States - Merz Investigative Site #001225
Loma Linda, California, United States - (and 40 more...)
|
|
| 99 |
NCT03779308 |
Recruiting |
Whole Body Vibration for Dystonia Cerebral Palsy |
|
- Device: whole body vibration therapy
|
Interventional
|
Not Applicable |
- The Hong Kong Polytechnic University
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Gross Motor Function Measure 66 Item Set (GMFM-66 IS)
- Two-minute walk test (2MWT)
- Barry-Albright Dystonia Scale (BADS)
- (and 3 more...)
|
10 |
All |
6 Years to 45 Years (Child, Adult) |
NCT03779308 |
G-YBPA |
WBVT |
January 1, 2019 |
October 30, 2019 |
December 31, 2019 |
December 18, 2018 |
January 3, 2019 |
|
- The Hong Kong Polytechnic University
Hung Hom, Hong Kong
|
|
| 100 |
NCT03428009 |
Recruiting |
Dystonia Genotype-Phenotype Correlation |
- Dystonia
- Dystonia; Idiopathic
- Dystonia, Primary
- (and 19 more...)
|
- Other: Magnetic Resonance Imaging
|
Observational
|
|
- University of Texas Southwestern Medical Center
- Massachusetts General Hospital
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Structural or functional imaging of dystonia and control groups
- Genetic Analysis of dystonia and control groups
|
200 |
All |
11 Years and older (Child, Adult, Older Adult) |
NCT03428009 |
STU122017-069 |
|
March 1, 2018 |
February 21, 2021 |
February 21, 2021 |
February 9, 2018 |
April 26, 2018 |
|
- University of Texas Southwestern Medical Center
Dallas, Texas, United States
|
|
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