| 1 |
NCT02524886 |
Terminated |
Deep Brain Stimulation for Patients With Tardive Dyskinesia and or Dystonia |
- Tardive Dyskinesia
- Tardive Dystonia
|
- Device: GPi DBS with Medtronic electorde and Activa PC pulsegenerator
|
Interventional
|
Not Applicable |
- GGZ Centraal
- University Medical Center Groningen
- Maastricht University
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- DBS efficacy as measured as the change on the Burke Fahn Marsden Dystonia Rating Scale (BFMDRS)
- Psychiatric safety as measured on the Brief Psychiatric Rating Scale (BPRS) and the Montgomery-Åsberg Depression Rating Scale (MADRS)
- Cognitive side effects as measured using neuropsychological test battery
- Quality of life as measured on the Short Form 36 (SF-36) and the World Health Organiasation Brief Quality of Life Score (WHO-Bref)
|
1 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02524886 |
DBS for TD |
|
June 2015 |
May 2, 2017 |
June 25, 2017 |
August 17, 2015 |
May 23, 2017 |
|
- Zon en Schild
Amersfoort, Utrecht, Netherlands
|
|
| 2 |
NCT03582891 |
Not yet recruiting |
Closed Loop Deep Brain Stimulation in Parkinson's Disease |
- Parkinson Disease
- Dystonia
|
|
Interventional
|
Not Applicable |
- University of California, San Francisco
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Duration of 'on' stimulation time without dyskinesia from motor diaries in adaptive compared to standard open loop stimulation.
- The Unified Parkinsons Disease Rating Scale (UPDRS) III scores off of medication in adaptive compared to standard open-loop stimulation.
- Schwab England scale in adaptive compared to standard open loop stimulation
- (and 4 more...)
|
20 |
All |
25 Years to 75 Years (Adult, Older Adult) |
NCT03582891 |
Activa RC+S |
|
July 2018 |
July 1, 2025 |
March 2028 |
July 11, 2018 |
July 11, 2018 |
|
|
|
| 3 |
NCT03562403 |
Not yet recruiting |
DBS in the Treatment of Intractable Movement Disorders |
- Parkinson Disease, Essential Tremors and Dystonia
|
- Device: Deep Brain Stimulation
|
Interventional
|
Not Applicable |
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in the unified parkinson's disease rating scale score
- Change in antiparkinsonian medication use
|
16 |
All |
25 Years to 90 Years (Adult, Older Adult) |
NCT03562403 |
DBS in movement disorders |
|
July 2018 |
April 2019 |
July 2019 |
June 19, 2018 |
June 19, 2018 |
|
|
|
| 4 |
NCT01495897 |
Completed |
Abnormal Movements, Cerebellum and Sensorimotor : Oculomotor Study |
- Healthy
- Dystonia
- Parkinson Disease
|
- Device: Tracking eye movement
- Device: Tracking eye movement under deep brain stimulation
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Saccadic adaptation
- Characteristics of the saccade
|
14 |
All |
18 Years and older (Adult, Older Adult) |
NCT01495897 |
C10-18
2010-A00740-39 |
MOUVADOC |
March 2011 |
March 2014 |
March 2014 |
December 20, 2011 |
February 24, 2016 |
|
- : Fédération des Maladies du Système Nerveux
Paris, France
|
|
| 5 |
NCT01888926 |
Completed |
The Effects of Repetitive Paired Associative Stimulation in Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Change from baseline in the motor evoked potential (MEP) amplitude at S50 after 30 minutes from rPAS (T30).
|
19 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT01888926 |
130163
13-N-0163 |
|
June 18, 2013 |
August 2, 2016 |
August 2, 2016 |
June 28, 2013 |
February 14, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 6 |
NCT00054652 |
Completed |
Survey of Sensory and Motor Tricks in Focal Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
80 |
All |
Child, Adult, Older Adult |
NCT00054652 |
030089
03-N-0089 |
|
February 2003 |
|
February 2005 |
February 6, 2003 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 7 |
NCT02106936 |
Terminated |
Depotentiation in People With Focal Hand Dystonia |
- Focal Dystonia
- Healthy Volunteers
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- Prachaya Srivanitchapoom, MD
- National Institutes of Health Clinical Center (CC)
|
NIH / Other |
- Observational Model: Other
- Time Perspective: Prospective
|
- Motor evoked potential amplitude
|
6 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02106936 |
140070
14-N-0070 |
|
March 5, 2014 |
June 20, 2017 |
June 20, 2017 |
April 8, 2014 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 8 |
NCT02911103 |
Recruiting |
Deep Brain Stimulation Surgery for Focal Hand Dystonia |
- Dystonia
- Focal Dystonia
- Musician's Dystonia
|
|
Interventional
|
Phase 1
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number and severity of adverse events
- Dystonia disability score
- FHD severity score
- (and 4 more...)
|
15 |
All |
22 Years to 100 Years (Adult, Older Adult) |
NCT02911103 |
160166
16-N-0166 |
|
September 21, 2016 |
September 1, 2020 |
September 30, 2020 |
September 22, 2016 |
November 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 9 |
NCT00325091 |
Completed |
Long-Term Motor Learning in Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
19 |
All |
18 Years and older (Adult, Older Adult) |
NCT00325091 |
060161
06-N-0161 |
|
May 9, 2006 |
|
January 6, 2014 |
May 12, 2006 |
February 15, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 10 |
NCT00105430 |
Completed |
Deep Brain Stimulation for Cervical Dystonia |
- Dystonia
- Generalized Primary Dystonia
|
- Procedure: Deep Brain Stimulation
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
- Clinical effectiveness of DBS of the Gpi or STN will be measured by the Burke-Fahn-Marsden Scale (BFM) and monitored over time to determine the effectiveness DBS and if there is an ideal anatomic stimulation site.@@@@@@@@@
- Determine the underlying pathophysiology of dystonia, and the mechanism of action of DBS.
|
40 |
All |
7 Years to 70 Years (Child, Adult, Older Adult) |
NCT00105430 |
050111
05-N-0111 |
|
March 2005 |
|
July 2006 |
March 14, 2005 |
July 6, 2006 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 11 |
NCT00031369 |
Terminated |
Brain Anatomy in Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
189 |
All |
18 Years and older (Adult, Older Adult) |
NCT00031369 |
020132
02-N-0132 |
|
February 27, 2002 |
|
March 10, 2015 |
March 4, 2002 |
October 6, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 12 |
NCT00132340 |
Completed |
Deep Brain Stimulation to Treat Cervical Dystonia |
|
|
Interventional
|
Phase 1 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT00132340 |
050222
05-N-0222 |
|
August 2005 |
|
July 2006 |
August 19, 2005 |
July 6, 2006 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 13 |
NCT00001784 |
Completed |
Mexiletine for the Treatment of Focal Dystonia |
- Blepharospasm
- Dystonia
- Spasm
|
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
24 |
All |
Child, Adult, Older Adult |
NCT00001784 |
980130
98-N-0130 |
|
July 1998 |
|
July 2002 |
November 4, 1999 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 14 |
NCT02882334 |
Recruiting |
Finger Individuation Training With a Training Device Versus Conventional Rehabilitation for Writer's Cramp |
|
- Device: Finger Force Manipulandum
- Other: Conventional physiotherapy
|
Interventional
|
Not Applicable |
- Fondation Ophtalmologique Adolphe de Rothschild
- Foundation Jacques and Gloria Gossweiler
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Investigator, Outcomes Assessor)
- Primary Purpose: Other
|
- change in writing speed after rehabilitation
|
50 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02882334 |
SSA_2016_15 |
FIDEX |
November 8, 2016 |
December 2019 |
December 2019 |
August 29, 2016 |
December 14, 2018 |
|
- Fondation Ophtalmologique A. de Rothschild
Paris, France
|
|
| 15 |
NCT03797638 |
Recruiting |
Characterization of Manual Dexterity by Finger Force Manipuladum (FFM) in Patients With Writer's Cramp and in Control Subjects |
- Dystonic Disorder
- Focal Dystonia
- Writer's Cramp
|
- Device: Finger Force Manipuladum (FFM)
|
Interventional
|
Not Applicable |
- Fondation Ophtalmologique Adolphe de Rothschild
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Manual dexterity by the FFM
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03797638 |
SSA_2018_4 |
FFM_CT |
October 1, 2018 |
May 31, 2019 |
May 31, 2019 |
January 9, 2019 |
January 9, 2019 |
|
- Fondation A de Rothschild
Paris, France
|
|
| 16 |
NCT02509338 |
Terminated |
Validation of the Implantation of a New Electrode for the Treatment of Dystonia |
- Generalized Dystonia
- Segmental Dystonia
- Tardive Dystonia
|
- Device: Electrode deep brain stimulation (Monopolar DBS Lead Model 09064-40cm)
|
Interventional
|
Not Applicable |
- University Hospital, Montpellier
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Technical feasibility of new electrode implantation
- Safety of new electrode implantation (evaluated by the occurence of side effects)
- clinical effect of deep brain stimulation using one contact-electrodes (Burke Fahn Marsden's dystonia rating scale and the Toronto Western Spasmodic Torticollis Rating Scale)
|
7 |
All |
18 Years to 64 Years (Adult) |
NCT02509338 |
9053 |
MONOCONTACT |
October 2013 |
December 2016 |
December 2016 |
July 28, 2015 |
May 22, 2018 |
|
- Chru Montpellier
Montpellier, France
|
|
| 17 |
NCT01921270 |
Completed
Has Results |
Dysport for the Treatment of OMD |
- Oral Dystonia
- Tardive Dystonia
|
- Drug: Low Dose - AbobotulinumtoxinA
|
Interventional
|
Phase 1
Phase 2 |
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Mean Global Dystonia Rating Scale Score as Measured by Blinded Rater
- Change in Analogue Pain Scale Score
- Mean Sialorrhea Clinical Scale for Parkinson's Disease (SCS-PD) Score
- (and 10 more...)
|
18 |
All |
18 Years and older (Adult, Older Adult) |
NCT01921270 |
IRB00064292 |
|
August 2013 |
February 8, 2017 |
February 8, 2017 |
August 13, 2013 |
November 17, 2017 |
November 17, 2017 |
- Wesley Woods Health Center; Emory University Hospital
Atlanta, Georgia, United States
|
|
| 18 |
NCT00506012 |
Terminated |
Pilot Efficacy Study of T2000 in Myoclonus Dystonia |
|
|
Interventional
|
Phase 2 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Effect of treatment on the movement disorder will be measured by a myoclonus scale and a dystonia scale as well as by assessment of overall functional status. Response at various dosages will be compared to baseline for all patients.
- Safety parameters including neurological examination, blood tests and EKG will be monitored throughout the treatment period and during withdrawal of the medication.
|
5 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00506012 |
T2000-0633 |
|
August 2007 |
August 2011 |
October 2011 |
July 25, 2007 |
December 23, 2013 |
|
- Investigator Site
Toronto, Ontario, Canada
|
|
| 19 |
NCT00331669 |
Unknown † |
Efficacy and Safety of Deep Brain Stimulation (DBS) of the Pallidal (GPi) in Patients With Tardive Dystonia |
- Dystonia
- Movement Disorder
|
- Procedure: deep brain stimulation
|
Interventional
|
Phase 2 |
- Charite University, Berlin, Germany
- Humboldt-Universität zu Berlin
- Ruhr University of Bochum
- (and 13 more...)
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Improvement of the motor scale of Burke-Fahn-Marsden-Dystonia Rating Scale via blinded video assessment 3 months after starting DBS in comparison to sham-stimulated patients
- AIMS
- Non-motor subscores of BMFDRS
- (and 3 more...)
|
24 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00331669 |
DBS and tardive dystonia |
|
May 2006 |
|
December 2010 |
May 31, 2006 |
March 4, 2009 |
|
- Andreas Kupsch
Berlin, Germany
|
|
| 20 |
NCT01581580 |
Recruiting |
Deep Brain Stimulation Surgery for Movement Disorders |
- Parkinson's Disease
- Essential Tremor
- Dystonia
|
- Procedure: Deep Brain Stimulation
|
Interventional
|
Not Applicable |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Other
|
- Change in UPDRS III scale, Burke-Fahn-Marsden (BFM) scale, and Tremor Rating Scale before and after treatment.
- Levels of effective drug therapy before/after surgery.
- Radiographic correlation of DBS electrode position and clinical changes.
- Neurophysiological mechanisms of DBS and motor/cognitive function in basal ganglia.
|
200 |
All |
18 Years and older (Adult, Older Adult) |
NCT01581580 |
110211
11-N-0211 |
|
July 12, 2011 |
January 1, 2020 |
March 1, 2021 |
April 20, 2012 |
December 25, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 21 |
NCT03270189 |
Recruiting |
Effect of the Visual Information Change in Functional Dystonia |
- Dystonia
- Dystonic Disorders
- Torticollis
- (and 5 more...)
|
|
Interventional
|
Not Applicable |
- Fondation Ophtalmologique Adolphe de Rothschild
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- measure of head movement occurring when writing
|
48 |
All |
18 Years to 71 Years (Adult, Older Adult) |
NCT03270189 |
SSA_2016_23 |
PRISMADYS |
September 18, 2017 |
October 2019 |
January 2020 |
September 1, 2017 |
January 23, 2019 |
|
- Fondation Ophtalmique Adolphe de Rothschild
Paris, France
|
|
| 22 |
NCT03471923 |
Recruiting |
Non-Motor Features of Cervical Dystonia (CD) |
- Cervical Dystonia
- Movement Disorders
- Focal Dystonia
- (and 5 more...)
|
- Diagnostic Test: Neurological Examination
- Diagnostic Test: Assessment of Non-Motor Features
|
Observational
|
|
- Vanderbilt University Medical Center
- Vanderbilt Institute for Clinical and Translational Research
|
Other |
- Observational Model: Cohort
- Time Perspective: Cross-Sectional
|
- Prevalence of spatial discrimination threshold in cervical dystonia patients, unaffected family members, and healthy volunteers
- Prevalence of temporal discrimination threshold in cervical dystonia patients, unaffected family members, and healthy volunteers
- Prevalence of vibration-induced illusion of movement in cervical dystonia patients, unaffected family members, and healthy volunteers
- (and 2 more...)
|
45 |
All |
18 Years and older (Adult, Older Adult) |
NCT03471923 |
171717 |
|
March 26, 2018 |
March 1, 2019 |
March 1, 2019 |
March 21, 2018 |
October 11, 2018 |
|
- Vanderbilt University Medical Center Clinical Research Center
Nashville, Tennessee, United States
|
|
| 23 |
NCT02046447 |
Completed |
Neuroimaging of Dystonia |
- Primary Cervical Dystonia
- DYT 1 Dystonia
|
- Drug: Primary Cervical Dystonia (Trihexyphenidyl)
- Other: Controls Primary Cervical Dystonia (Trihexyphenidyl)
- Other: DYT 1 Dystonia (Healthy Control)
- Other: DYT 1 Dystonia
|
Observational
|
|
- University of Florida
- Bachmann Strauss Dystonia & Parkinson Foundation, Inc.
|
Other / Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task
- Change in cerebral blood flow based on blood-oxygen-level dependent (BOLD) contrast during a precision gripping task after administration of trihexyphenidyl compared to change in BOLD contrast during a precision gripping task
|
20 |
All |
7 Years to 70 Years (Child, Adult, Older Adult) |
NCT02046447 |
354-2013 |
NID |
May 2014 |
December 2015 |
December 2017 |
January 27, 2014 |
December 22, 2017 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 24 |
NCT00208091 |
Completed
Has Results |
Quantifying Musical Performance After Treatment With Myobloc in Musician's Dystonia |
|
- Drug: Botulinum toxin, type B
|
Interventional
|
Phase 4 |
- Columbia University
- Solstice Neurosciences
|
Other / Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Note Errors (Related to Errors in Duration)
- Note Errors (Related to Errors in Loudness)
- Subjective Assessment Ratings of Change
|
16 |
All |
25 Years to 69 Years (Adult, Older Adult) |
NCT00208091 |
AAAB2808 |
|
April 2003 |
May 2008 |
May 2008 |
September 21, 2005 |
May 9, 2014 |
May 9, 2014 |
- Neurological Institute, 710 W. 168th Street, NI-1112
New York, New York, United States
|
|
| 25 |
NCT00702754 |
Completed
Has Results |
An Open Label Safety and Immunogenicity Study of MYOBLOC (Neurobloc; Botulinum Toxin Type B) Injectable Solution in Patients With Cervical Dystonia |
|
- Biological: Botulinum Toxin Type B
|
Interventional
|
Phase 4 |
|
Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Treatment Assessment Scale (TAS), 4 Wks Post-injection Compared to Baseline (Time 0), Rating of Cervical Dystonia Symptoms
- Treatment Assessment Scale (TAS), Approx Wk 12 + 4 Wks Post-Injection Compared to Baseline. Rating of Cervical Dystonia Symptoms
- Treatment Assessment Scale (TAS), Approx Wk 24 + 4 Wks Post-injection Compared to Baseline. Rating of Cervical Dystonia Symptoms
- (and 5 more...)
|
502 |
All |
18 Years and older (Adult, Older Adult) |
NCT00702754 |
401CDNA |
|
June 2001 |
May 2008 |
September 2008 |
June 20, 2008 |
October 2, 2009 |
September 23, 2009 |
|
|
| 26 |
NCT02015039 |
Completed
Has Results |
Pilot Trial of Botulinum Toxin and Occupational Therapy for Writer's Cramp |
|
- Drug: BoNT Injections
- Procedure: Occupational Therapy
|
Interventional
|
Phase 1
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Using a Patient Rated Subjective Scale (Visual Analogue Scale), Change From Baseline With Botulinum Toxin Therapy Plus Occupational Therapy Compared to Botulinum Toxin Therapy Alone at 20 Weeks.
- Change in the Writers Cramp Rating Scale (WCRS) From Baseline to Week 20 in Participants Receiving Botulinum Toxin Therapy Alone Compared With Botulinum Toxin Therapy Plus Occupational Therapy.
- Change on the Writer's Cramp Impairment Scale (WCIS) Score From Baseline to 20 Weeks.
- (and 4 more...)
|
13 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT02015039 |
140030
14-N-0030 |
|
December 3, 2013 |
September 13, 2016 |
September 13, 2016 |
December 19, 2013 |
March 20, 2018 |
January 23, 2018 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 27 |
NCT00122044 |
Completed |
Childhood Hypertonia of Central Origin: A Trial of Anticholinergic Treatment Effects |
|
|
Interventional
|
Phase 2 |
- University of Southern California
- United Cerebral Palsy Foundation
- Don and Linda Carter Foundation
- Crowley Carter Foundation
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Melbourne assessment of upper extremity function
- Barry-Albright Dystonia Scale
- Burke-Fahn-Marsden Dystonia Scale
- (and 3 more...)
|
35 |
All |
5 Years to 17 Years (Child) |
NCT00122044 |
CHOCOLATE |
|
January 2003 |
December 2004 |
December 2004 |
July 21, 2005 |
May 23, 2014 |
|
- University of Alabama School of Medicine
Birmingham, Alabama, United States - Stanford University
Stanford, California, United States - Rehabilitation Institute of Chicago
Chicago, Illinois, United States - (and 4 more...)
|
|
| 28 |
NCT00137384 |
Completed |
Movement-Related Brain Networks Involved in Hand Dystonia |
- Movement Disorder
- Focal Dystonia
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
|
60 |
All |
18 Years and older (Adult, Older Adult) |
NCT00137384 |
050228
05-N-0228 |
|
August 25, 2005 |
|
April 27, 2018 |
August 29, 2005 |
May 1, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 29 |
NCT02689466 |
Recruiting |
Cholinergic Receptor Imaging in Dystonia |
- Cervical Dystonia
- Dystonia
- Movement Disorder
- Focal Dystonia
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Characterize the M2 muscarinic acetycholine receptor binding in cervical dystonia patients as measured with high-resolution positron emission tomography (PET) using [18F]FP-TZTP
|
54 |
All |
18 Years and older (Adult, Older Adult) |
NCT02689466 |
160064
16-N-0064 |
|
February 20, 2016 |
July 2, 2019 |
July 3, 2019 |
February 24, 2016 |
October 16, 2018 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 30 |
NCT02252380 |
Recruiting |
ExAblate Transcranial MRgFUS for the Management of Treatment-Refractory Movement Disorders |
- Movement Disorders
- Essential Tremor
- Holmes Tremor
- (and 6 more...)
|
- Device: Transcranial ExAblate System
|
Interventional
|
Not Applicable |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Severity of Device and Procedure Related Complications
|
10 |
All |
18 Years to 85 Years (Adult, Older Adult) |
NCT02252380 |
MD003 |
|
May 2015 |
December 2019 |
December 2020 |
September 30, 2014 |
February 11, 2019 |
|
- Sunnybrook Health Sciences Centre
Toronto, Ontario, Canada - Toronto Western Hospital
Toronto, Ontario, Canada
|
|
| 31 |
NCT00165776 |
Completed
Has Results |
Randomized, Double-Blind, Placebo-Controlled, Parallel, Group Dose-Response, Study of E2014 in Patients WIth Spasmodic Torticollis |
- Cervical Dystonia
- Spasmodic Torticollis
|
- Drug: BOTULINUM TOXIN TYPE B
|
Interventional
|
Phase 2 |
- Eisai Co., Ltd.
- Eisai Inc.
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double
- Primary Purpose: Treatment
|
- Mean Change From Baseline in the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) -Total Score at Week 4 After Treatment
- Mean Change From Baseline in Patient Global Assessment - Visual Analog Scale (PtGA-VAS) at Week 4 After Treatment
- Mean Change From Baseline in Physician Global Assessment Disease Assessment - Visual Analog Scale (PGA-VAS) at Week 4 After Treatment
- (and 4 more...)
|
133 |
All |
20 Years to 74 Years (Adult, Older Adult) |
NCT00165776 |
E2014-J081-131 |
|
June 2004 |
May 2006 |
November 2006 |
September 14, 2005 |
March 10, 2014 |
January 8, 2014 |
- Ichihara, Chiba -prefecture, Japan
- Kitakyushu, Fukuoka -prefecture, Japan
- Sapporo, Hokkaido, Japan
- (and 18 more...)
|
|
| 32 |
NCT02107261 |
Recruiting |
Incobotulinum Toxin A (Xeomin®) As A Treatment For Focal Task-Specific Dystonia Of The Musician's Hand |
|
- Drug: incobotulinumtoxin A
|
Interventional
|
Phase 2 |
- Icahn School of Medicine at Mount Sinai
- Merz North America, Inc.
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Patient and Physician Global Perception of change
- Quantitative MIDI Analysis comparison
- Blinded high speed video analysis comparison
- (and 2 more...)
|
20 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02107261 |
GCO 13-1679 |
|
March 2014 |
July 2019 |
July 2019 |
April 8, 2014 |
November 5, 2018 |
|
- NYU Langone Health
New York, New York, United States - Icahn School of Medicine at Mount Sinai
New York, New York, United States
|
|
| 33 |
NCT03664375 |
Completed |
Impact Of Physiotherapy And Botox In Improving Functional Outcomes Among Post Stroke Focal Dystonia Patients |
|
- Other: Botulinum toxin type A
- Other: Task Specific Training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Action Research Arm Test (ARAT):
- MOTOR ASSESSMENT SCALE (MAS)
- WOLF MOTOR FUNCTION TEST (WMFT)
- (and 3 more...)
|
39 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT03664375 |
IIRS-IUISB/PHD/008 |
|
November 2015 |
August 2016 |
December 2016 |
September 10, 2018 |
September 10, 2018 |
|
|
|
| 34 |
NCT03481491 |
Not yet recruiting |
Interactions Between Striatum and Cerebellum in ADCY5 and PRRT2 Dystonias |
|
- Other: transcranial magnetic stimulation of the cerebellum
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Resting state functional connectivity between the cerebellum and the striatum
- Amplitude of Low Frequency Fluctuation (ALFF) of blood oxygen level-dependent signal in the cerebellum
- Fractional anisotropy (FA) of the cerebello-striatal tract
- (and 3 more...)
|
104 |
All |
183 Months and older (Child, Adult, Older Adult) |
NCT03481491 |
C16-128
2017-A01843-50 |
AMEDYST |
May 4, 2018 |
July 3, 2021 |
July 3, 2022 |
March 29, 2018 |
March 29, 2018 |
|
|
|
| 35 |
NCT00971854 |
Unknown † |
Alteration of Deep Brain Stimulation Parameters for Dystonia |
|
- Procedure: Alteration of deep brain stimulator settings
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To assess if the stimulation frequency of 60 Hz is superior to 130 Hz for patients with primary dystonia who have responded poorly to standard 130 Hz pallidal stimulation
- Assess any potential changes in anxiety, mood, cognition
|
20 |
All |
18 Years and older (Adult, Older Adult) |
NCT00971854 |
09/H0603/11
R&D Study - 5898 |
|
September 2009 |
January 2010 |
February 2010 |
September 4, 2009 |
October 14, 2009 |
|
- University of Oxford, Nuffield Department of Surgery
Oxford, Oxfordshire, United Kingdom
|
|
| 36 |
NCT03318120 |
Recruiting |
Exercise Training in Dystonia |
|
- Behavioral: Progressive Resistance Training
- Behavioral: Standardized Exercise Training
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating Scale Score
- Burke-Fahn-Marsden Dystonia Rating Scale score
- Transcranial Magnetic Stimulation (TMS)
- (and 3 more...)
|
194 |
All |
30 Years to 80 Years (Adult, Older Adult) |
NCT03318120 |
IRB201702224
Pending |
|
November 6, 2017 |
December 1, 2020 |
December 1, 2020 |
October 23, 2017 |
October 15, 2018 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 37 |
NCT01823237 |
Recruiting |
Effect of Increasing Motor Cortex Inhibition on Task Specific Dystonia |
|
- Device: Transcranial Magnetic Stimulation
|
Interventional
|
Not Applicable |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Diagnostic
|
- Efficacy of TMS on task-specific focal hand dystonia
|
15 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01823237 |
IRB00062538
DYST |
|
February 2013 |
December 2019 |
April 2020 |
April 4, 2013 |
February 8, 2019 |
|
- Emory University School of Medicine
Atlanta, Georgia, United States
|
|
| 38 |
NCT02583074 |
Recruiting |
Clinical Trial of STN-DBS for Primary Cranial-Cervical Dystonia |
|
- Procedure: Stimulation
- Procedure: Sham-stimulation
|
Interventional
|
Not Applicable |
- Beijing Tiantan Hospital
- Peking Union Medical College Hospital
- The First Affiliated Hospital of Dalian Medical University
- China-Japan Friendship Hospital
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change of motor and disability scores
- Quality of life
- Depression
|
40 |
All |
Child, Adult, Older Adult |
NCT02583074 |
ZYLX201305 |
STN-CCD |
September 15, 2015 |
December 31, 2018 |
December 31, 2018 |
October 21, 2015 |
March 20, 2018 |
|
- Beijing Tiantan Hospital Affiliated to Capital Medical University
Beijing, Beijing, China - Beijing Tiantan Hospital Affiliated to Capital Medical University
Beijing, China
|
|
| 39 |
NCT03351218 |
Recruiting |
Agency in Dystonia |
|
- Behavioral: Behavioral testing - computerized tasks
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- agency tasks behavioral outcome measures
- MRI measures
|
100 |
All |
15 Years to 65 Years (Child, Adult, Older Adult) |
NCT03351218 |
C17-04
2017-A01231-52 |
AGENT10 |
October 23, 2017 |
October 23, 2019 |
December 23, 2019 |
November 22, 2017 |
November 22, 2017 |
|
- Centre d'investigation Clinique
Paris, Ile De France, France
|
|
| 40 |
NCT03078816 |
Recruiting |
Thalamic Deep Brain Stimulation for Secondary Dystonia in Children and Young Adults |
|
- Device: Activa PC Primary Cell Neurostimulator - (Model 37601)
- Device: Activa RC Rechargeable Neurostimulator - (Model 37612)
- Device: Activa SC Single Cell Neurostimulator (Models 37602/37603)
- (and 6 more...)
|
Interventional
|
Phase 1 |
- University of California, San Francisco
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Adverse Events (AEs) and serious adverse events (SAEs)
- Burke-Fahn-Marsden Dystonia Rating Scale
- Pediatric Quality of Life Inventory (PedsQL)
- (and 8 more...)
|
15 |
All |
7 Years to 25 Years (Child, Adult) |
NCT03078816 |
123822A |
DBSVop |
March 3, 2017 |
May 2019 |
May 2019 |
March 13, 2017 |
May 2, 2017 |
|
- University of California San Francisco Hospital
San Francisco, California, United States
|
|
| 41 |
NCT01792336 |
Suspended |
Transcranial Magnetic Stimulation for Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Time Perspective: Prospective
|
- Motor evoked potential following TMS conditioning versus the baseline MEP amplitude in dystonia patients and healthy subjects.
|
30 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT01792336 |
130076
13-N-0076 |
|
February 13, 2013 |
December 30, 2019 |
December 30, 2019 |
February 15, 2013 |
February 8, 2019 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 42 |
NCT03017586 |
Recruiting |
Efficacy and Safety of DBS in Patients With Primary Dystonia |
|
- Device: Beijing Pins Medical Co., Ltd. Deep Brain Stimulator
|
Interventional
|
Not Applicable |
- Beijing Pins Medical Co., Ltd
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- change in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score
- Short-Form General Health Survey (SF-36)
- Visual analogue scale
- (and 4 more...)
|
70 |
All |
6 Years to 60 Years (Child, Adult) |
NCT03017586 |
PINS-023 |
|
December 27, 2017 |
September 2019 |
December 2019 |
January 11, 2017 |
March 15, 2018 |
|
- Beijing XieHe Hospital
Beijing, Beijing, China - Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University
Hangzhou, Zhejiang, China
|
|
| 43 |
NCT01460771 |
Unknown † |
Transcranial Direct-Current Stimulation in Childhood Dystonia |
- Childhood Onset Dystonias
|
- Device: TDCS (Transcranial Direct-current Stimulation)
- Device: sham TDCS (Transcranial Direct-current Stimulation)
|
Interventional
|
Phase 2 |
- University of Southern California
- National Institutes of Health (NIH)
- Crowley Carter Foundation
- Don and Linda Carter Foundation
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
|
100 |
All |
4 Years to 21 Years (Child, Adult) |
NCT01460771 |
TDCS2011 |
|
September 2011 |
September 2017 |
September 2017 |
October 27, 2011 |
May 22, 2014 |
|
- University of Southern California
Los Angeles, California, United States
|
|
| 44 |
NCT01738581 |
Completed
Has Results |
rTMS and Retraining in Focal Hand Dystonia |
|
- Device: Repetitive Transcranial Magnetic Stimulation
- Behavioral: Sensorimotor Retraining
- Behavioral: Non-specific Therapy
|
Interventional
|
Phase 1
Phase 2 |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change From Baseline in Global Rating of Change at Posttest (Day 5)
- Change From Baseline in Arm Dystonia Disability Scale at Posttest (Day 5)
- Change From Baseline in Sensation at Posttest (Day 5)
- (and 4 more...)
|
9 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT01738581 |
DSS0608M91226 |
DSS |
November 2011 |
June 2015 |
June 2015 |
November 30, 2012 |
February 20, 2017 |
June 28, 2016 |
- University of Minnesota, Program in Physical Therapy
Minneapolis, Minnesota, United States - Program in Physical Therapy, University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 45 |
NCT02199509 |
Completed
Has Results |
Efficacy of Levetiracetam in Oromandibular and Cranial Dystonia |
- Oromandibular Dystonia
- Cranial Dystonia
|
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Other
|
- Percent Change of the Sum of the Eyes, Mouth, Speech and Swallowing Subscores of the Burke-Fahn-Marsden (BFM) Dystonia Scale.
- Percent Change of the Sum of the Eyes, Mouth, Speech and Swallowing Subscores of Burke-Fahn-Marsten Dystonia Rating Scale (BFM)
- Percent Change of the Sum of Eyes and Upper Face, Lower Face and Jaw and Tongue Subscores of the GDS Rating Scale
|
8 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02199509 |
140152
14-N-0152 |
|
July 2014 |
March 2016 |
March 2016 |
July 24, 2014 |
July 11, 2017 |
July 11, 2017 |
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 46 |
NCT03587350 |
Completed |
Assessing Cervical Dystonia |
|
- Device: Shimmer monitoring
|
Interventional
|
Not Applicable |
- The Leeds Teaching Hospitals NHS Trust
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- Successful monitoring of movement by the shimmer monitor
|
24 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03587350 |
NE16/88973 |
|
April 7, 2017 |
January 31, 2018 |
January 31, 2018 |
July 16, 2018 |
July 16, 2018 |
|
- Leeds Teaching Hospitals NHS Trust
Leeds, West Yorkshire, United Kingdom
|
|
| 47 |
NCT02686125 |
Recruiting |
Registry of Deep Brain Stimulation With the VERCISE™ System for Treatment of Dystonia: Vercise DBS Dystonia Registry |
|
- Device: Deep Brain Stimulation (DBS)
|
Observational
|
|
- Boston Scientific Corporation
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of subjects with reduction in dystonia symptoms as assessed by BFMDRS score
- Proportion of cervical dystonia subjects with reduction in symptoms as assessed by TWSTRS score
|
200 |
All |
7 Years and older (Child, Adult, Older Adult) |
NCT02686125 |
A4012 |
|
March 2016 |
December 2021 |
December 2024 |
February 19, 2016 |
January 16, 2019 |
|
- Boston Scientific Clinical Research Information
Valencia, California, United States
|
|
| 48 |
NCT02263417 |
Unknown † |
A Randomized Controlled Trail Comparing Subthalamic and Pallidal Deep Brain Stimulation for Dystonia |
|
- Device: Deep Brain Stimulation (DBS) of Gpi
- Device: Deep Brain Stimulation (DBS) of STN
|
Interventional
|
Early Phase 1 |
- Beijing Pins Medical Co., Ltd
- Peking Union Medical College Hospital
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Burke-Fahn-Marsden Scale (BFM)
- Quality of life (SF-36)
- Psychiatric assessment (HADS-D and PANSS)
|
40 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02263417 |
PINS-005 |
|
July 2015 |
December 2018 |
December 2018 |
October 13, 2014 |
October 11, 2016 |
|
- Peking union medical college hospital
Beijing, Beijing, China
|
|
| 49 |
NCT01761903 |
Active, not recruiting |
Functional Connectivity in Primary Focal Dystonia |
|
|
Observational
|
|
- University of Colorado, Denver
|
Other |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
- Contrast between Primary Focal Dystonia (PFD) and Healthy Controls (HC)
- Correlation between basal ganglia motor network functional connectivity measures and total PFD clinical assessment scale scores
- Evaluation of Lateralization
- Statistical dependence between symptoms and measures of basal ganglia functional connectivity
|
60 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01761903 |
12-0289 |
|
May 2012 |
January 2019 |
September 2019 |
January 7, 2013 |
November 28, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States
|
|
| 50 |
NCT01272154 |
Unknown † |
Cerebellum and Cortical Plasticity: the Case of Dystonia |
|
- Other: Transcranial magnetic stimulation
|
Interventional
|
Not Applicable |
- Institut National de la Santé Et de la Recherche Médicale, France
- Sree Chitra Tirunal Institute for Medical Sciences & Technology
- Policlinico G . Martino, Messina Italy
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Single (Participant)
- Primary Purpose: Basic Science
|
- Comparison of MEP0/MEP10 and MEP0/MEP30 values obtained after sham, cRTBS or iTBS of the cerebellum.
- Variation of the appropriate dystonic clinical score (depending on the type of dystonia) after each rTMS session (cTBS, iTBS, sham).
- Measurement of number of errors, mean time to reach the target after each rTMS session (cTBS, iTBS, sham).
- Measurement of the variation of the motor threshold, intracortical inhibition and intracortical facilitation after each rTMS session (cTBS, iTBS, sham).
|
120 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT01272154 |
C10-01
2010-A00931-38 |
CERDYS |
January 2011 |
January 2013 |
January 2014 |
January 7, 2011 |
January 31, 2012 |
|
- Hpôpital Pitié Sapétrière - U 975 Plate forme " Pole Exploration de l'homme : Gait, Equilibrium, Posture, and Movement "
Paris, France
|
|
| 51 |
NCT03363113 |
Completed |
Outcome of Botulinum Toxin Treatment for Oromandibular Dystonia |
|
|
Observational
|
|
- Fondation Ophtalmologique Adolphe de Rothschild
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- Clinical improvement score
|
240 |
All |
18 Years and older (Adult, Older Adult) |
NCT03363113 |
CE_20150630_7_LSM |
rétroBODOM |
January 1, 2016 |
April 1, 2016 |
July 12, 2016 |
December 6, 2017 |
December 6, 2017 |
|
|
|
| 52 |
NCT03381456 |
Completed |
Task-dependent Operation of a Mechanism Intracortical Inhibition in Dystonia |
|
|
Interventional
|
Not Applicable |
- University Hospital, Lille
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- long-interval intracortical inhibition (LICI) level
|
20 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT03381456 |
2013_51
2014-A00244-43 |
LICIdystonie |
April 2015 |
April 2017 |
April 2017 |
December 22, 2017 |
December 22, 2017 |
|
- Hôpital Roger Salengro, CHRU de Lille
Lille, France
|
|
| 53 |
NCT03608397 |
Recruiting |
Single Treatment of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-1) |
|
- Biological: DaxibotulinumtoxinA for injection
- Biological: Placebo
|
Interventional
|
Phase 3 |
- Revance Therapeutics, Inc.
- Syneos Health
|
Industry / Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Change from Baseline Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)-total score
- Change from Baseline TWSTRS-total score
- Duration of effect
- (and 2 more...)
|
301 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03608397 |
1720302 |
ASPEN-1 |
June 20, 2018 |
September 30, 2020 |
September 30, 2020 |
August 1, 2018 |
August 3, 2018 |
|
- HOPE Research Institute
Phoenix, Arizona, United States - Movement Disorders Center of Arizona
Scottsdale, Arizona, United States - The Parkinsons and Movement Disorder Institute
Fountain Valley, California, United States - (and 7 more...)
|
|
| 54 |
NCT02982304 |
Unknown † |
Multi-Target Pallidal and Thalamic Deep Brain Stimulation for Hemi-Dystonia |
- Dystonia
- Dystonia, Secondary
|
- Device: Deep Brain Stimulation
|
Interventional
|
Phase 1 |
- University of British Columbia
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Burke Fahn Marsden Disability Rating Scale (BFMDRS)
- SF-36 Quality of Life Scale
- Adverse effects of Vim or Vim + GPi Neuromodulation
|
4 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02982304 |
H14-03185 |
|
January 2015 |
December 2017 |
|
December 5, 2016 |
December 5, 2016 |
|
- Vancouver General Hospital
Vancouver, British Columbia, Canada
|
|
| 55 |
NCT00773604 |
Completed |
Deep Brain Stimulation in Patients With Dystonia |
|
- Device: Medtronic implantable deep brain stimulation (DBS) system
|
Interventional
|
Phase 1
Phase 2 |
- University of California, San Francisco
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- The primary outcome measure is the change in Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) movement score from baseline to 12 months.
|
22 |
All |
7 Years to 80 Years (Child, Adult, Older Adult) |
NCT00773604 |
Private donor |
STN DBS |
June 2008 |
February 2015 |
February 2015 |
October 16, 2008 |
August 7, 2015 |
|
- San Francisco Veterans Administration Medical Center
San Francisco, California, United States - University of California, San Francisco
San Francisco, California, United States
|
|
| 56 |
NCT00760318 |
Terminated |
Keppra for Cervical Dystonia |
|
|
Interventional
|
Phase 2 |
- University of South Florida
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Primary endpoint will be the difference in change in TWSTRS score from baseline to week 16.
- Secondary outcome measures will include difference in change in TWSTRS score from baseline to weeks 4, 8, 12, 16, 20, and 24 in patient-reported duration of benefit for their Botox injection, and length of time between injections.
|
17 |
All |
18 Years and older (Adult, Older Adult) |
NCT00760318 |
UCB Pharma- Keppra |
Keppra |
November 2005 |
October 2007 |
October 2007 |
September 26, 2008 |
November 22, 2018 |
|
|
|
| 57 |
NCT01373424 |
Recruiting |
The Dystonia Coalition Natural History and Biospecimen Repository for Isolated Dystonias |
|
|
Observational
|
|
- Hyder A. Jinnah, MD, PhD
- National Institute of Neurological Disorders and Stroke (NINDS)
- Office of Rare Diseases (ORD)
- (and 3 more...)
|
Other / NIH / Industry |
- Observational Model: Other
- Time Perspective: Other
|
|
5000 |
All |
18 Years and older (Adult, Older Adult) |
NCT01373424 |
IRB00046266
U54TR001456
RDCRN#6301
U54NS065701 |
DCP |
January 2011 |
June 2020 |
August 2021 |
June 15, 2011 |
August 8, 2018 |
|
- University of Alabama, Birmingham
Birmingham, Alabama, United States - Mayo Clinic, Arizona
Scottsdale, Arizona, United States - Parkinson's and Movement Disorders Institute
Fountain Valley, California, United States - (and 39 more...)
|
|
| 58 |
NCT02468843 |
Completed |
Novel Stimulation Patterns for the Treatment of Dystonia |
- Dystonia
- Cervical Dystonia
|
- Device: Biphasic DBS stimulation
- Other: Unified Dystonia Rating Scale
- Other: Burke-Fahn- Marsden scale
|
Observational
|
|
- University of Florida
- Medtronic
|
Other / Industry |
- Observational Model: Case-Only
- Time Perspective: Prospective
|
- Blinded Unified Dystonia Rating Scale (UDRS)
- Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS)
- Tremor accelerometer to measure motor dysfunction
- (and 3 more...)
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02468843 |
IRB201500366 |
|
July 2015 |
January 2016 |
August 2016 |
June 11, 2015 |
October 27, 2016 |
|
- Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States
|
|
| 59 |
NCT03617367 |
Recruiting |
Long-Term Safety and Efficacy of Repeat Treatments of DaxibotulinumtoxinA for Injection in Adults With Isolated Cervical Dystonia (ASPEN-OLS) |
|
- Biological: daxibotulinumtoxinA for injection
|
Interventional
|
Phase 3 |
- Revance Therapeutics, Inc.
- Syneos Health
|
Industry / Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Long Term Safety of patients determined by the incidence of treatment-emergent adverse events
- The proportion of subjects with at least moderate improvement on the Clinician Global Impression of Change (CGIC) at Weeks 4 or 6 for Treatment Cycles 1, 2, 3, and 4
- The average of the change from Baseline in the TWSTRS Total Score at Weeks 4 and 6 for Treatment Cycles 1, 2, 3, and 4 [Time Frame: Weeks 4 and 6 of treatment cycles 1, 2, 3, and 4 (12 - 52 weeks duration each)]
|
350 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03617367 |
1720304 |
ASPEN-OLS |
September 5, 2018 |
November 30, 2021 |
November 30, 2021 |
August 6, 2018 |
September 20, 2018 |
|
- Kansas Institute of Reseach
Overland Park, Kansas, United States
|
|
| 60 |
NCT02420106 |
Recruiting |
Effect of Osteopathic Manipulative Medicine on Motor Function and Quality of Life in Cervical Dystonia |
|
- Procedure: Osteopathic Manipulative Medicine
|
Interventional
|
Not Applicable |
- New York Institute of Technology
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change in Motor Function
- Change in Quality of Life
|
50 |
All |
2 Years to 100 Years (Child, Adult, Older Adult) |
NCT02420106 |
BHS-983 |
|
February 2014 |
August 2018 |
August 2018 |
April 17, 2015 |
October 10, 2017 |
|
- New York Institute of Technology
Old Westbury, New York, United States
|
|
| 61 |
NCT00950664 |
Completed
Has Results |
A Study to Compare Dysport® and Botox® in the Treatment of Cervical Dystonia |
|
- Drug: Dysport® (abobotulinumtoxinA)
- Drug: Botox® (onabotulinumtoxinA)
|
Interventional
|
Phase 4 |
- Seoul National University Hospital
- Ipsen
- Medical Research Collaborating Center, Seoul, Korea
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Triple (Participant, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Reduction of Total Tsui Score at 4 Weeks From Baseline
- Reduction of Total TWSTRS Score at 4 Weeks From Baseline
- CGI-I (Clinical Global Impression of Illness)
- PGI-I (Patient's Global Impression of Improvement)
|
103 |
All |
20 Years to 80 Years (Adult, Older Adult) |
NCT00950664 |
H-0902-049-272 |
|
August 2009 |
January 2011 |
July 2011 |
August 3, 2009 |
July 5, 2017 |
October 11, 2013 |
- Bundang Seoul Natiuonal University Hospital
Seongnam, Gyeong-gi, Korea, Republic of - Dong-A University Hospital
Busan, Korea, Republic of - Hanyang University Hospital
Seoul, Korea, Republic of - (and 4 more...)
|
|
| 62 |
NCT02180139 |
Withdrawn |
tDCS in Cervical Dystonia |
|
- Device: transcranial direct current stimulation
|
Interventional
|
Not Applicable |
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Cervical Dystonia Questionnaire (CDQ-24)
- Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- Visual Analog Scale (VAS)
- Cortical Excitability as measured by transcranial magnetic stimulation
|
0 |
All |
21 Years to 65 Years (Adult, Older Adult) |
NCT02180139 |
TDCS-2014 |
|
September 2017 |
September 2017 |
December 2017 |
July 2, 2014 |
October 3, 2017 |
|
- University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 63 |
NCT00102999 |
Completed |
Brain Function in Focal Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
118 |
All |
18 Years and older (Adult, Older Adult) |
NCT00102999 |
050094
05-N-0094 |
|
January 31, 2005 |
|
January 22, 2009 |
February 7, 2005 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 64 |
NCT00447772 |
Completed
Has Results |
Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia |
|
- Drug: Botulinum type A toxin (Dysport®)
|
Interventional
|
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Change From Baseline in the Total Score of the Tsui Rating Scale (Patient in Sitting Position) at the First On-treatment Visit (Week 4 or Week 12)
- Change in the Total Score of the Tsui Rating Scale (Patient in Sitting Position) Between Visit 1 (Week 0) and Visit 3 (Week 12)
- Change in the Total Score of the Tsui Rating Scale (Patient Walking) Between Baseline (Week 0) and Visit 2 (Week 4) and Visit 3 (Week 12)
- (and 6 more...)
|
516 |
All |
18 Years and older (Adult, Older Adult) |
NCT00447772 |
A-94-52120-098 |
|
October 2004 |
February 2008 |
April 2008 |
March 15, 2007 |
January 14, 2019 |
July 30, 2018 |
- Krankenhaus der Barmherzigen Brüder
Graz, Austria - NÖ LKH Grimmenstein-Hochegg
Grimmenstein, Austria - Univ.-Klinik für Neurologie
Innsbruck, Austria - (and 103 more...)
|
|
| 65 |
NCT03805152 |
Not yet recruiting |
Abobotulinum Toxin and Neubotulinum Toxin Injection in Cerivical Dystonia |
|
- Drug: Neuronox(R)
- Drug: Dysport (R)
|
Interventional
|
Phase 3 |
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Toronto Western Spasmodic Torticollis Rating scale ( TWSTRS)
- Cervical Dystonia Impact Profile 58 ( CDIP-58)
- Comparesion the quality of life 36 item ( SF 36)
- (and 3 more...)
|
50 |
All |
18 Years to 100 Years (Adult, Older Adult) |
NCT03805152 |
A-01-2019 |
DNCD |
April 23, 2019 |
July 31, 2020 |
August 31, 2020 |
January 15, 2019 |
February 18, 2019 |
|
|
|
| 66 |
NCT02959645 |
Recruiting |
Assessment of Brain Activities in Cervical Dystonia |
|
|
Observational
|
|
- University of Minnesota - Clinical and Translational Science Institute
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- Hand Joint Position Sense
- Brain Signals Recorded via Non-Invasive Surface Electromyography
|
40 |
All |
18 Years to 78 Years (Adult, Older Adult) |
NCT02959645 |
1607M91461 |
|
September 1, 2017 |
July 2020 |
July 2020 |
November 9, 2016 |
August 23, 2018 |
|
- Elliott Hall-MSP Lab
Minneapolis, Minnesota, United States
|
|
| 67 |
NCT00004421 |
Completed |
Deep Brain Stimulation in Treating Patients With Dystonia |
|
- Device: implanted pulse generator
|
Interventional
|
Phase 2
Phase 3 |
- Icahn School of Medicine at Mount Sinai
- FDA Office of Orphan Products Development
|
Other |
- Primary Purpose: Treatment
|
|
15 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00004421 |
199/13315
MTS-FDR001452 |
|
September 1997 |
|
September 2000 |
October 19, 1999 |
March 25, 2015 |
|
- Mount Sinai Medical Center, NY
New York, New York, United States
|
|
| 68 |
NCT03206112 |
Recruiting |
Loss of Depotentiation in Focal Dystonia |
- Focal Dystonia
- Healthy Volunteers
|
|
Interventional
|
Early Phase 1 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Allocation: Non-Randomized
- Intervention Model: Factorial Assignment
- Masking: None (Open Label)
- Primary Purpose: Basic Science
|
- MEP amplitude immediately after the PAS25-cTBS150 (depotentiation) protocol
- MEP amplitudes
|
40 |
All |
18 Years and older (Adult, Older Adult) |
NCT03206112 |
170123
17-N-0123 |
|
September 20, 2017 |
December 31, 2019 |
December 31, 2019 |
July 2, 2017 |
December 14, 2018 |
|
- National Institutes of Health Clinical Center
Bethesda, Maryland, United States
|
|
| 69 |
NCT00773253 |
Completed
Has Results |
Botox for Cervical Dystonia Following EMG Mapping |
|
|
Interventional
|
Phase 4 |
- University of California, San Francisco
- Allergan
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Pre- and Post-injection Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS): Global Clinical Impression Scale (GCI); Visual Analog Scale(VAS)
- Mean Percentage Change in Total Toronto Western Spasmodic Torticollis Rating Scale
|
10 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT00773253 |
Allergan cervical dystonia |
|
April 2008 |
October 2010 |
January 2011 |
October 16, 2008 |
October 13, 2011 |
October 13, 2011 |
- University of California, San Francisco
San Francisco, California, United States
|
|
| 70 |
NCT00082615 |
Completed |
Neurophysiological Markers in Patients With Craniofacial Dystonia and Their Relatives |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
210 |
All |
18 Years and older (Adult, Older Adult) |
NCT00082615 |
040188
04-N-0188 |
|
May 11, 2004 |
|
April 21, 2008 |
May 13, 2004 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 71 |
NCT01884064 |
Completed
Has Results |
Repetitive Transcranial Magnetic Stimulation for the Treatment of Focal Hand Dystonia |
- Dystonia, Focal, Task-specific
|
- Device: rTMS
- Device: Sham rTMS
|
Interventional
|
Phase 1 |
- University of Minnesota - Clinical and Translational Science Institute
- Dystonia Medical Research Foundation
- National Institutes of Health (NIH)
- National Center for Research Resources (NCRR)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
|
17 |
All |
21 Years to 75 Years (Adult, Older Adult) |
NCT01884064 |
0608M91226
M01RR000400 |
|
July 2008 |
July 2010 |
July 2010 |
June 21, 2013 |
June 17, 2016 |
November 2, 2015 |
- Program in Physical Therapy, University of Minnesota
Minneapolis, Minnesota, United States
|
|
| 72 |
NCT01671527 |
Completed |
Insights Into Deep Brain Stimulation (DBS) for Cervical Dystonia |
|
- Procedure: Transcranial magnetic stimulation (TMS)
|
Observational
|
|
- University of Florida
- National Institutes of Health (NIH)
- Dystonia Coalition
|
Other / NIH |
- Observational Model: Case Control
- Time Perspective: Prospective
|
- The body's response to transcranial magnetic stimulation (TMS)
- Clinical assessment of dystonia severity
|
29 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01671527 |
3142012
KL2TR000065 |
|
August 2012 |
March 2016 |
June 2016 |
August 23, 2012 |
June 13, 2016 |
|
- University of Florida
Gainesville, Florida, United States
|
|
| 73 |
NCT00132990 |
Unknown † |
A Multicenter Pilot Study of Pallidal Deep Brain Stimulation for Cervical Dystonia |
|
- Device: Deep brain stimulation
|
Interventional
|
Not Applicable |
- University of Calgary
- Canadian Institutes of Health Research (CIHR)
- Calgary Health Region
- Medtronic
|
Other / Industry |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: Single
- Primary Purpose: Treatment
|
- Improvement in neck postures/movements
- Improvement in quality of life
- Document adverse effects of surgery
|
10 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00132990 |
16760 |
|
February 2003 |
|
September 2005 |
August 22, 2005 |
January 12, 2007 |
|
- Dr. Zelma Kiss
Calgary, Alberta, Canada - Dr. Matt Wheatley
Edmonton, Alberta, Canada - Dr. Chris Honey
Vancouver, British Columbia, Canada - (and 2 more...)
|
|
| 74 |
NCT01806805 |
Completed |
Efficacy Trial of Zonisamide for Myoclonus Dystonia |
|
- Drug: zonegran
- Drug: placebo
|
Interventional
|
Phase 3 |
- Assistance Publique - Hôpitaux de Paris
|
Other |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Measure of the evolution of the severity of myoclonus by a specific scale (UMRS)
- Measure of the evolution of the severity of dystonia by a specific scale (BFM)
- measure of the evolution of the severity of myoclonus by electromyographic recording
|
24 |
All |
18 Years to 60 Years (Adult) |
NCT01806805 |
P091104 |
EpsilonZêta |
February 2012 |
July 2014 |
July 2014 |
March 7, 2013 |
April 24, 2015 |
|
- Pitié salpetriere hospital
Paris, France
|
|
| 75 |
NCT00310414 |
Completed |
fMRI Studies of Task Specificity in Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
51 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00310414 |
060128
06-N-0128 |
|
March 30, 2006 |
|
March 13, 2012 |
April 3, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 76 |
NCT00309010 |
Completed |
Neurophysiology of Task-Specificity of Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
115 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00309010 |
060126
06-N-0126 |
|
March 28, 2006 |
|
February 24, 2009 |
March 30, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 77 |
NCT02662530 |
Recruiting |
Clinical and Kinematic Assessment for Determination of Botox® Injection Parameters in Cervical Dystonia |
|
- Drug: Botulinum Toxin Type A
|
Interventional
|
Phase 2 |
- Western University, Canada
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Number of participants with significant relief of severity and pain by TWSTRS part A and C, respectively, over treatment course
- Number of participants with significant relief of severity by objective kinematic reductions in angular deviation and amplitude measures over treatment course
- Number of participants with significant improvement in functional disability scores assessed by TWSTRS part B and patient-reported scores pre- and post-BoNT-A parameters determined visually or kinematically.
- Number of participants with significant relief of severity by global impression of change scores over treatment course
|
50 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT02662530 |
105515 |
|
January 2012 |
June 2016 |
January 2020 |
January 25, 2016 |
February 20, 2018 |
|
- London Health Sciences Centre
London, Ontario, Canada
|
|
| 78 |
NCT02542839 |
Recruiting |
rTMS and Botulinum Toxin in Primary Cervical Dystonia |
- Primary Cervical Dystonia
- Dystonia
|
- Device: NeuroStar TMS therapy
- Device: Sham NeuroStar TMS therapy
- Other: Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- (and 3 more...)
|
Interventional
|
Not Applicable |
- University of Florida
- American Brain Foundation
- Neuronetics
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Triple (Participant, Care Provider, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Dystonia severity as assessed by the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS)
- Physiological impact of TMS measured by Cerebellar Inhibition(CBI)
- Quality of life as assessed by Craniocervical Dystonia Questionnaire
|
35 |
All |
30 Years to 75 Years (Adult, Older Adult) |
NCT02542839 |
IRB201500341 |
|
November 2015 |
September 2019 |
September 2019 |
September 7, 2015 |
August 24, 2018 |
|
- UF Center for Movement Disorders & Neurorestoration
Gainesville, Florida, United States - UF Brain Institute
Gainesville, Florida, United States
|
|
| 79 |
NCT03369613 |
Recruiting |
Transcranial Electrical Stimulation for Cervical Dystonia |
- Primary Cervical Dystonia
|
- Device: transcranial electrical stimulation
|
Interventional
|
Not Applicable |
- University of Colorado, Denver
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Basic Science
|
- Phase I: A change in brain functional connectivity in primary cervical dystonia
- Phase II: Improvement in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) score
|
55 |
All |
18 Years and older (Adult, Older Adult) |
NCT03369613 |
17-1322 |
|
October 27, 2017 |
December 2019 |
December 2019 |
December 12, 2017 |
December 27, 2018 |
|
- University of Colorado Denver
Aurora, Colorado, United States
|
|
| 80 |
NCT00306865 |
Completed |
Brain Changes in Patients With Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT00306865 |
060031
06-N-0031 |
|
March 17, 2006 |
|
October 14, 2010 |
March 24, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 81 |
NCT00323765 |
Completed |
Plasticity in Cervical Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
44 |
All |
18 Years and older (Adult, Older Adult) |
NCT00323765 |
060157
06-N-0157 |
|
May 5, 2006 |
|
May 20, 2008 |
May 10, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 82 |
NCT02131467 |
Recruiting |
Safety and Tolerability of Perampanel in Cervical Dystonia |
|
|
Interventional
|
Phase 1
Phase 2 |
- University Health Network, Toronto
- Dystonia Study Group
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Number of subjects able to remain on study drug for minimum of 4 weeks.
- Safety will be evaluated as the cumulative number of new adverse events collected at each visit from Baseline to visit 4
|
30 |
All |
18 Years to 65 Years (Adult, Older Adult) |
NCT02131467 |
17-5864.4 |
SAFE-PER-CD |
September 1, 2017 |
January 2020 |
January 2020 |
May 6, 2014 |
February 4, 2019 |
|
- Emory University School of Medicine
Atlanta, Georgia, United States - Rush University Medical Center
Chicago, Illinois, United States - Beth Israel Medical Center
New York, New York, United States - (and 2 more...)
|
|
| 83 |
NCT01180270 |
Completed |
Static Graviceptive Functions in Patients With Cervical Dystonia (CD) |
|
|
Observational
|
|
- Kirsten Elwischger
- Medical University of Vienna
|
Other |
- Time Perspective: Prospective
|
- Subjective visual vertical (SVV), measured in degree (°)
- SVV in degree (°)
- Degree of head deviation (°)
- degree of head deviation (°)
|
45 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT01180270 |
SVV_CD1 |
|
June 2010 |
January 2012 |
January 2012 |
August 12, 2010 |
January 31, 2012 |
|
- Department of neurology, Medical University of Vienna
Vienna, Austria
|
|
| 84 |
NCT03232320 |
Recruiting |
Meditoxin® Treatment in Patients With Cervical Dystonia |
- Dystonia
- Dystonic Disorder
|
- Drug: Meditoxin
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change in Toronto Western Spasmodic Torticollis Rating Scale Total Score From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Severity Subscale as a change From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Disability Subscale as a change From Baseline
- Toronto Western Spasmodic Torticollis Rating Scale Pain Subscale as a change From Baseline
|
66 |
All |
20 Years to 75 Years (Adult, Older Adult) |
NCT03232320 |
MT01-KR16CVD309 |
|
July 6, 2017 |
October 31, 2019 |
December 31, 2019 |
July 27, 2017 |
August 9, 2017 |
|
- Asan Medical Center
Seoul, Korea, Republic of
|
|
| 85 |
NCT02618889 |
Completed |
OnabotulinumtoxinA in the Management of Psychogenic Dystonia |
|
|
Interventional
|
Phase 4 |
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Rating Scale for Psychogenic Movement Disorders (RSPMD)
- Clinical Global Impression (CGI) of change
- Hamilton Depression Rating Scale (HAM-D)
- Hamilton Anxiety Rating Scale (HAM-A)
|
18 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02618889 |
2015-4496 |
|
January 15, 2016 |
May 30, 2017 |
June 30, 2017 |
December 2, 2015 |
November 30, 2018 |
|
- Alberto Espay
Cincinnati, Ohio, United States
|
|
| 86 |
NCT02069548 |
Completed |
Analysis of Three-dimensional Movements of the Head in Cervical Dystonia |
|
|
Observational
|
|
- Fondation Ophtalmologique Adolphe de Rothschild
|
Other |
- Observational Model: Case Control
- Time Perspective: Cross-Sectional
|
- Range of motion of the voluntary mobility of the cervical spine in the three spatial planes
- movements disorders in cervical dystonia
- head posture
- range of motion
|
63 |
All |
18 Years to 70 Years (Adult, Older Adult) |
NCT02069548 |
2013-A01400-45 |
STAC1 |
February 2014 |
April 2015 |
April 2015 |
February 24, 2014 |
October 24, 2016 |
|
- Fondation Ophtalmologique Adolphe de Rothschild
Paris, Ile de France, France
|
|
| 87 |
NCT01753349 |
Completed |
Phase IV-Cervical Dystonia-INTEREST IN CD2 |
|
- Drug: BoNT-A injections, 3-4 times yearly
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Change in subject's satisfaction using a 5-point Likert scale.
- Change from baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) total score and severity sub-scale.
- Change in tremor associated with CD using Tsui score
- (and 3 more...)
|
1050 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753349 |
Y-79-52120-166 |
INTEREST_INCD2 |
December 2012 |
September 2017 |
September 25, 2017 |
December 20, 2012 |
January 7, 2019 |
|
- Parkinson's and Movement Disorders Center of Maryland
Elkridge, Maryland, United States - Tufts Medical Center, Inc
Boston, Massachusetts, United States - The Parkinson's and Movement Disorders Center
Southfield, Michigan, United States - (and 110 more...)
|
|
| 88 |
NCT00021853 |
Completed |
Motor Training to Treat Hand Dystonia |
|
- Behavioral: constraint-induced movement therapy
|
Interventional
|
Phase 2 |
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Primary Purpose: Treatment
|
|
15 |
All |
Child, Adult, Older Adult |
NCT00021853 |
010217
01-N-0217 |
|
August 2001 |
|
August 2002 |
August 9, 2001 |
March 4, 2008 |
|
- National Institute of Neurological Disorders and Stroke (NINDS)
Bethesda, Maryland, United States
|
|
| 89 |
NCT01433757 |
Completed |
Ampicillin for DYT-1 Dystonia Motor Symptoms |
|
- Drug: Ampicillin
- Drug: Sugar pill
|
Interventional
|
Phase 1 |
- University of Florida
- Tyler's Hope for a Dystonia Cure, Inc
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Safety and tolerability of Ampicillin in treating DYT-1 dystonia
- Burke-Fahn Marsden Dystonia Rating Scale (BFM-DRS)
|
2 |
All |
7 Years to 80 Years (Child, Adult, Older Adult) |
NCT01433757 |
301-2011 |
|
September 2011 |
June 2017 |
June 2017 |
September 14, 2011 |
July 5, 2017 |
|
- UF Center for Movement Disorders and Neurorestoration
Gainesville, Florida, United States
|
|
| 90 |
NCT00025701 |
Completed |
EEG and EMG Studies of Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
75 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT00025701 |
020010
02-N-0010 |
|
October 9, 2001 |
|
October 4, 2010 |
October 12, 2001 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 91 |
NCT01753336 |
Completed
Has Results |
Long Term Safety And Effectiveness Of Dysport® In Adults With Cervical Dystonia |
|
|
Interventional
|
Phase 3 |
|
Industry |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- TWSTRS Total Score at Week 4 and Week 12 for Treatment Cycles 1, 2 and 3.
- TWSTRS Total Scores at Pretreatment Baseline, Week 4 and Week 12 for Treatment Cycles 1, 2 and 3.
- Treatment Response in Treatment Cycle 3 Week 4.
- (and 3 more...)
|
112 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753336 |
A-TL-52120-170 |
|
March 2013 |
October 2015 |
October 2015 |
December 20, 2012 |
May 4, 2017 |
May 4, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Movement Disorders Center of Arizona, LLC
Scottsdale, Arizona, United States - University of Arizona
Tucson, Arizona, United States - (and 38 more...)
|
|
| 92 |
NCT01753310 |
Completed
Has Results |
Efficacy and Safety of DYSPORT® Using 2mL Dilution in Adults With Cervical Dystonia. |
|
- Drug: Dysport®
- Drug: Placebo
|
Interventional
|
Phase 3 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Investigator)
- Primary Purpose: Treatment
|
- Change From Baseline in Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) Total Score at Week 4.
- Change From Baseline in TWSTRS Total Score at Week 2.
- Change From Baseline in Clinical Global Impression of Change (CGIC) in CD at Week 2.
- (and 5 more...)
|
134 |
All |
18 Years and older (Adult, Older Adult) |
NCT01753310 |
A-TL-52120-169 |
|
January 2013 |
October 2014 |
January 2015 |
December 20, 2012 |
March 16, 2017 |
March 16, 2017 |
- University of Alabama at Birmingham
Birmingham, Alabama, United States - Movement Disorders Center of Arizona, LLC
Scottsdale, Arizona, United States - University of Arizona
Tucson, Arizona, United States - (and 39 more...)
|
|
| 93 |
NCT00376753 |
Completed |
Muscle Contraction in Patients With Focal Hand Dystonia |
|
|
Observational
|
|
- National Institute of Neurological Disorders and Stroke (NINDS)
- National Institutes of Health Clinical Center (CC)
|
NIH |
|
|
84 |
All |
18 Years and older (Adult, Older Adult) |
NCT00376753 |
060242
06-N-0242 |
|
September 11, 2006 |
|
May 11, 2011 |
September 15, 2006 |
July 2, 2017 |
|
- National Institutes of Health Clinical Center, 9000 Rockville Pike
Bethesda, Maryland, United States
|
|
| 94 |
NCT02727361 |
Recruiting |
Role of the Striatal Cholinergic System in the Pathophysiology of Dystonia |
|
- Radiation: PET (Positron Emission Tomography) imaging
- Other: MRI : Magnetic Resonance Imaging
|
Interventional
|
Not Applicable |
- University Hospital, Bordeaux
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Health Services Research
|
|
40 |
All |
18 Years to 75 Years (Adult, Older Adult) |
NCT02727361 |
CHUBX2014/20 |
DYSCHOL |
January 2016 |
January 2018 |
January 2018 |
April 4, 2016 |
August 4, 2017 |
|
- CHU de Bordeaux
Bordeaux, France
|
|
| 95 |
NCT03247868 |
Recruiting |
A Multimodal Approach to Cervical Dystonia Treatment With Association of Botulinum Toxin and Motor Learning Techniques |
- Cervical Dystonia,Primary
|
- Combination Product: Botulinum Toxin+SPRInt
|
Interventional
|
Not Applicable |
- Fondazione Don Carlo Gnocchi Onlus
|
Other |
- Intervention Model: Sequential Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Dystonia phenomenology improvement
- quality of life
- brain plasticity
- (and 5 more...)
|
20 |
All |
18 Years to 80 Years (Adult, Older Adult) |
NCT03247868 |
SPRIntFdG |
SPRInt |
March 16, 2016 |
March 28, 2018 |
June 30, 2018 |
August 14, 2017 |
August 14, 2017 |
|
- IRCCS Fondazione Don Gnocchi
Milano, MI, Italy
|
|
| 96 |
NCT01840462 |
Completed |
Longitudinal Study for Treatment With Botulinum Toxin A Injections in naïve and Pre-treated Patients Suffering From Cervical Dystonia [CD-NIS-Longterm] |
|
|
Observational
|
|
|
Industry |
- Observational Model: Case-Control
- Time Perspective: Prospective
|
|
372 |
All |
18 Years and older (Adult, Older Adult) |
NCT01840462 |
A-94-52120-165 |
CDNISLongterm |
July 2012 |
November 2015 |
March 2016 |
April 25, 2013 |
January 14, 2019 |
|
- Graz, Austria
- Wiesbaden, Germany
|
|
| 97 |
NCT00954408 |
Completed |
Fatigue in Dystonia (a Single Session, Questionnaire-based Study of Fatigue in Dystonia) |
|
|
Observational
|
|
|
Other |
- Observational Model: Case-Only
- Time Perspective: Cross-Sectional
|
- To determine the prevalence of fatigue and sleepiness in patients with dystonia.
|
123 |
All |
21 Years and older (Adult, Older Adult) |
NCT00954408 |
108-2008 |
FID |
July 2009 |
July 2011 |
July 2011 |
August 7, 2009 |
September 19, 2011 |
|
- University of Florida Movement Disorders Center
Gainesville, Florida, United States
|
|
| 98 |
NCT01314365 |
Completed |
DYSPORT™ Clinical & Health Economics Outcomes Registry in Cervical Dystonia |
|
|
Observational
|
|
|
Industry |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Proportion of treatment responders using the Toronto Western Spasmodic Torticollis Rating Scale (TWSTRS) severity scale score
- Patient Global Impression of Change using the 7-point Likert scale
- Clinical Global Impression of Change using the 7-point Likert scale
- (and 4 more...)
|
350 |
All |
18 Years and older (Adult, Older Adult) |
NCT01314365 |
A-TL-52120-156 |
ANCHOR-CD |
April 2011 |
November 2013 |
March 2014 |
March 14, 2011 |
April 30, 2014 |
|
- Arizona Dystonia Institute
Scottsdale, Arizona, United States - East Bay Physicians Medical Group
Berkeley, California, United States - Headache Center
Encinitas, California, United States - (and 42 more...)
|
|
| 99 |
NCT01486264 |
Completed |
Open-Label Non-Inferiority Study Evaluating the Efficacy and Safety of Xeomin® in Subjects With Cervical Dystonia Flex |
|
|
Interventional
|
Phase 4 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Single Group Assignment
- Masking: Single (Outcomes Assessor)
- Primary Purpose: Treatment
|
- Efficacy of the Short Flex dosing of Xeomin® compared to the Long Flex dosing regimen of Xeomin®,
|
286 |
All |
18 Years to 81 Years (Adult, Older Adult) |
NCT01486264 |
MUS 60201 4073 1 |
|
December 1, 2011 |
March 2016 |
February 28, 2017 |
December 6, 2011 |
April 27, 2017 |
|
- Merz Investigative Site #001234
Birmingham, Alabama, United States - Merz Investigative Site 001017
Fountain Valley, California, United States - Merz Investigative Site #001225
Loma Linda, California, United States - (and 40 more...)
|
|
| 100 |
NCT00703287 |
Completed |
Specialized Physiotherapy Program for Cervical Dystonia |
|
|
Interventional
|
Not Applicable |
- Dr Donald Grosset
- University of Aberdeen
- South Glasgow University Hospitals NHS Trust
|
Other |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Double (Participant, Outcomes Assessor)
- Primary Purpose: Treatment
|
- To compare different types of physiotherapy for treating condition
|
110 |
All |
16 Years and older (Child, Adult, Older Adult) |
NCT00703287 |
SN07NE039 |
|
January 2008 |
May 2010 |
December 2010 |
June 23, 2008 |
February 4, 2013 |
|
- Southern General Hospital, 1345 Govan Road
Glasgow, Scotland, United Kingdom
|
|
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