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47 studies found for:    DNMT1
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Rank Status Study
1 Unknown  Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
Conditions: Schizophrenia;   Cigarette Smoking
Interventions: Drug: Varenicline;   Drug: Placebo for varenicline
2 Completed
Has Results
Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome
Conditions: Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndromes;   Myelodysplastic Syndromes;   Refractory Anemia;   Refractory Anemia With Excess Blasts;   Refractory Anemia With Ringed Sideroblasts;   Refractory Cytopenia With Multilineage Dysplasia;   Thrombocytopenia
Interventions: Other: flow cytometry;   Other: DNA methylation analysis;   Other: cytogenetic analysis;   Drug: decitabine;   Genetic: microarray analysis;   Genetic: gene expression analysis;   Other: pharmacological study;   Genetic: polymorphism analysis
3 Not yet recruiting Decitabine and Talazoparib in Untreated AML and R/R AML
Condition: Acute Myeloid Leukemia
Interventions: Drug: Decitabine;   Drug: talazoparib
4 Active, not recruiting Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid
Condition: Head and Neck Squamous Cell Carcinoma
Interventions: Drug: Valproic Acid;   Drug: Placebo
5 Completed
Has Results
Low-dose Temozolomide for 2 Weeks on Brain Tumor Enzyme in Patients With Gliomas (P04602 AM1) (Completed)
Condition: Glioma
Intervention: Drug: temozolomide
6 Completed Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
Conditions: Bone Marrow Suppression;   Brain and Central Nervous System Tumors;   Drug/Agent Toxicity by Tissue/Organ
Interventions: Procedure: filgrastim;   Biological: gene therapy;   Drug: lomustine;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Procedure: in vitro-treated peripheral blood stem cell transplantation
7 Completed Decitabine With or Without Valproic Acid in Treating Patients With Relapsed or Refractory Non-Hodgkin's Lymphoma
Conditions: Recurrent Adult Burkitt Lymphoma;   Recurrent Adult Diffuse Large Cell Lymphoma;   Recurrent Mantle Cell Lymphoma
Interventions: Drug: decitabine;   Drug: valproic acid;   Other: pharmacological study;   Other: laboratory biomarker analysis
8 Not yet recruiting p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Pancreatic Cancer
Condition: Metastatic Pancreatic Adenocarcinoma
Interventions: Drug: Tetrahydrouridine;   Drug: Decitabine
9 Not yet recruiting Nivolumab Alone or in Combination With Decitabine/Tetrahydrouridine in Non-small Cell Lung Cancer
Conditions: Lung Cancer;   Non-small Cell Lung Cancer
Interventions: Drug: Nivolumab;   Drug: oral decitabine;   Drug: Tetrahydrouridine
10 Completed KRAS Wild-type Metastatic Colorectal Cancer Trial
Condition: Colorectal Cancer
Interventions: Drug: Dacogen™ (decitabine);   Drug: Vectibix® (panitumumab)
11 Completed Varenicline Effects In Schizophrenic Smokers
Conditions: Schizophrenia;   Tobocco Use Disorder;   Nicotine Dependance
Intervention: Drug: Varenicline
12 Completed A Phase 1 Study of CC-486 as a Single Agent and in Combination With Carboplatin or ABI-007 in Subjects With Relapsed or Refractory Solid Tumors
Conditions: Urinary Bladder Neoplasms;   Carcinoma, Transitional Cell;   Ovarian Neoplasms;   Fallopian Tube Neoplasms;   Peritoneal Neoplasms;   Carcinoma, Non-Small-Cell Lung;   Carcinoma, Pancreatic Ductal;   Tumor Virus Infections
Interventions: Drug: CC-486;   Drug: Carboplatin;   Drug: ABI-007
13 Terminated
Has Results
Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic Syndromes
Conditions: Leukemia;   Myelodysplastic Syndromes
Interventions: Biological: lintuzumab;   Drug: 5-azacytidine
14 Not yet recruiting Oral THU-Decitabine + Nivolumab for Advanced Non-Small Cell Lung Cancer
Condition: Advanced Non-Small Cell Lung Cancer
Interventions: Drug: Nivolumab;   Drug: Oral THU;   Drug: Decitabine
15 Active, not recruiting Effect of Quercetin on Green Tea Polyphenol Uptake in Prostate Tissue From Patients With Prostate Cancer Undergoing Surgery
Conditions: Adenocarcinoma of the Prostate;   Recurrent Prostate Cancer;   Stage I Prostate Cancer;   Stage IIA Prostate Cancer;   Stage IIB Prostate Cancer;   Stage III Prostate Cancer;   Stage IV Prostate Cancer
Interventions: Dietary Supplement: green tea extract;   Drug: quercetin;   Other: placebo;   Procedure: therapeutic conventional surgery;   Other: laboratory biomarker analysis
16 Not yet recruiting Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)
Conditions: Chronic Myelomonocytic Leukemia;   Juvenile Myelomonocytic Leukemia;   Atypical Chronic Myeloid Leukemia;   Myeloproliferative Neoplasm;   Myelodysplastic Syndromes;   Myelofibrosis
Interventions: Drug: Pacritinib;   Drug: Decitabine
17 Terminated
Has Results
Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)
Conditions: Colorectal Neoplasm;   Head and Neck Neoplasm;   Carcinoma, Non-Small-Cell Lung;   Esophageal Neoplasm
Intervention: Drug: Temozolomide
18 Recruiting Study of Nivolumab Compared to Temozolomide, Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)
Condition: Brain Cancer
Interventions: Drug: Nivolumab;   Drug: Temozolomide;   Radiation: Radiotherapy
19 Recruiting Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer).
Condition: Brain Neoplasms
Interventions: Drug: Nivolumab;   Drug: Temozolomide;   Radiation: Radiotherapy;   Other: Nivolumab Placebo
20 Recruiting Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors
Conditions: Neoplasms;   Solid Tumors
Intervention: Drug: TdCyd

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