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52 studies found for:    DNMT1
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Rank Status Study
1 Completed
Has Results
Differentiation Therapy With Decitabine in Treating Patients With Myelodysplastic Syndrome
Conditions: Chronic Myelomonocytic Leukemia;   de Novo Myelodysplastic Syndromes;   Myelodysplastic Syndromes;   Refractory Anemia;   Refractory Anemia With Excess Blasts;   Refractory Anemia With Ringed Sideroblasts;   Refractory Cytopenia With Multilineage Dysplasia;   Thrombocytopenia
Interventions: Other: flow cytometry;   Other: DNA methylation analysis;   Other: cytogenetic analysis;   Drug: decitabine;   Genetic: microarray analysis;   Genetic: gene expression analysis;   Other: pharmacological study;   Genetic: polymorphism analysis
2 Not yet recruiting Decitabine and Talazoparib in Untreated AML and R/R AML
Condition: Acute Myeloid Leukemia
Interventions: Drug: Decitabine;   Drug: talazoparib
3 Completed
Has Results
Low-dose Temozolomide for 2 Weeks on Brain Tumor Enzyme in Patients With Gliomas (P04602 AM1) (Completed)
Condition: Glioma
Intervention: Drug: temozolomide
4 Completed Combination Chemotherapy Plus Gene Therapy in Treating Patients With CNS Tumors
Conditions: Bone Marrow Suppression;   Brain and Central Nervous System Tumors;   Drug/Agent Toxicity by Tissue/Organ
Interventions: Procedure: filgrastim;   Biological: gene therapy;   Drug: lomustine;   Drug: procarbazine hydrochloride;   Drug: vincristine sulfate;   Procedure: in vitro-treated peripheral blood stem cell transplantation
5 Not yet recruiting Safety Study of VAL-083 and Radiotherapy in Patients With Newly Diagnosed GBM Having Unmethylated MGMT Expression
Conditions: Glioma;   Glioblastoma;   Glioblastoma Multiforme;   GBM;   Brain Cancer
Intervention: Drug: VAL-083 (Dianhydrogalactitol)
6 Not yet recruiting p53/p16-Independent Epigenetic Therapy With Oral Decitabine/Tetrahydrouridine for Pancreatic Cancer
Condition: Metastatic Pancreatic Adenocarcinoma
Interventions: Drug: Tetrahydrouridine;   Drug: Decitabine
7 Unknown  Varenicline for Cognitive Deficits and Cigarette Smoking in Schizophrenia - Efficacy and Predictors
Conditions: Schizophrenia;   Cigarette Smoking
Interventions: Drug: Varenicline;   Drug: Placebo for varenicline
8 Completed KRAS Wild-type Metastatic Colorectal Cancer Trial
Condition: Colorectal Cancer
Interventions: Drug: Dacogen™ (decitabine);   Drug: Vectibix® (panitumumab)
9 Not yet recruiting Nivolumab Alone or in Combination With Decitabine/Tetrahydrouridine in Non-Small Cell Lung Cancer
Conditions: Lung Cancer;   Non-small Cell Lung Cancer
Interventions: Drug: Nivolumab;   Drug: oral decitabine;   Drug: Tetrahydrouridine
10 Active, not recruiting Chemoprevention of Head and Neck Squamous Cell Carcinoma (HNSCC) With Valproic Acid
Condition: Head and Neck Squamous Cell Carcinoma
Interventions: Drug: Valproic Acid;   Drug: Placebo
11 Completed Varenicline Effects In Schizophrenic Smokers
Conditions: Schizophrenia;   Tobocco Use Disorder;   Nicotine Dependance
Intervention: Drug: Varenicline
12 Terminated
Has Results
Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study P04273AM2)(TERMINATED)
Conditions: Colorectal Neoplasm;   Head and Neck Neoplasm;   Carcinoma, Non-Small-Cell Lung;   Esophageal Neoplasm
Intervention: Drug: Temozolomide
13 Not yet recruiting Entinostat and Pembrolizumab in Treating Patients With Myelodysplastic Syndrome After DNMTi Therapy Failure
Condition: Previously Treated Myelodysplastic Syndrome
Interventions: Drug: Entinostat;   Other: Laboratory Biomarker Analysis;   Biological: Pembrolizumab
14 Recruiting Guadecitabine and Atezolizumab in Treating Patients With Advanced Myelodysplastic Syndrome or Chronic Myelomonocytic Leukemia That Is Refractory or Relapsed
Conditions: Chronic Myelomonocytic Leukemia;   Myelodysplastic Syndrome;   Recurrent Acute Myeloid Leukemia With Myelodysplasia-Related Changes
Interventions: Drug: Atezolizumab;   Drug: Guadecitabine
15 Recruiting Study of Nivolumab Compared to Temozolomide, Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer)
Condition: Brain Cancer
Interventions: Drug: Nivolumab;   Drug: Temozolomide;   Radiation: Radiotherapy
16 Recruiting Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer).
Condition: Brain Neoplasms
Interventions: Drug: Nivolumab;   Drug: Temozolomide;   Radiation: Radiotherapy;   Other: Nivolumab Placebo
17 Not yet recruiting Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk Myelofibrosis or Myeloproliferative Neoplasm (MPN)/Myelodysplastic Syndrome (MDS)
Conditions: Chronic Myelomonocytic Leukemia;   Juvenile Myelomonocytic Leukemia;   Atypical Chronic Myeloid Leukemia;   Myeloproliferative Neoplasm;   Myelodysplastic Syndromes;   Myelofibrosis
Interventions: Drug: Pacritinib;   Drug: Decitabine
18 Recruiting Phase I Trial of 4'-Thio-2'-Deoxycytidine (TdCyd) in Patients With Advanced Solid Tumors
Conditions: Neoplasms;   Solid Tumors
Intervention: Drug: TdCyd
19 Completed
Has Results
Study of Recurrent Prostate Cancer With Rising Prostate Specific Antigen (PSA)
Condition: Prostate Cancer
Intervention: Drug: Disulfiram
20 Recruiting Study of VAL-083 in Patients With MGMT Unmethylated, Bevacizumab-naive Recurrent Glioblastoma
Conditions: Glioma;   Glioblastoma;   Glioblastoma Multiforme;   GBM;   Brain Cancer
Intervention: Drug: VAL-083, Dianhydrogalactitol

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Study has passed its completion date and status has not been verified in more than two years.