| 1 |
NCT00183092 |
Completed
Has Results |
CJD (Creutzfeldt-Jakob Disease) Quinacrine Study |
- Creutzfeldt-Jakob Disease
|
- Drug: Quinacrine
- Drug: Placebo
|
Interventional |
Phase 2 |
- University of California, San Francisco
- National Institute on Aging (NIA)
|
Other / NIH |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
- Primary Purpose: Treatment
|
- Primary Survival
- Change in Mini-Mental State Examination (MMSE) After 2 Months
- Barthel Score Change After 2 Months
- (and 5 more...)
|
69 |
All |
18 Years and older (Adult, Senior) |
NCT00183092 |
IA0083
P01AG021601 |
|
April 2005 |
June 2012 |
June 2012 |
September 16, 2005 |
June 9, 2014 |
May 29, 2014 |
- University of California, San Francisco
San Francisco, California, United States
|
| 2 |
NCT02480725 |
Not yet recruiting |
The Role of the Coagulation Pathway at the Synapse in Prion Diseases |
- Creutzfeldt-Jakob Syndrome
|
- Procedure: collect CSF (Cerebrospinal fluid) sample
|
Observational |
|
- Sheba Medical Center
- Prof. Zerr , Prion Referral Center , University of Gottingen, Germany
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
|
50 |
All |
35 Years to 90 Years (Adult, Senior) |
NCT02480725 |
1702-14 SMC |
|
June 2015 |
July 2024 |
July 2025 |
June 24, 2015 |
June 24, 2015 |
|
|
| 3 |
NCT01050881 |
Unknown † |
Notification of Donors With Positive Microbiology Markers |
- Human Immunodeficiency Virus
- Hepatitis B
- Hepatitis C
- (and 3 more...)
|
|
Observational |
|
- NHS Blood and Transplant
- Welsh Blood Service
- Scottish National Blood Transfusion Service
- Irish Blood Transfusion Service
|
Other |
- Observational Model: Case-Only
- Time Perspective: Retrospective
|
- The primary outcome measure for the study is the reported level of satisfaction with the notification process, including the information provided and the donor's emotional response.
|
600 |
All |
18 Years to 65 Years (Adult) |
NCT01050881 |
001/DNS |
|
February 2010 |
June 2010 |
October 2010 |
January 18, 2010 |
February 15, 2010 |
|
- NHS Blood and Transplant, Transfusion Microbiology
Colindale, London, United Kingdom
|
| 4 |
NCT02629640 |
Recruiting |
Enhanced CJD Surveillance in the Older Population |
|
- Other: Medical history questionnaire
- Other: Clinical assessment and review
- Other: Participant follow-up
- (and 2 more...)
|
Observational |
|
- University of Edinburgh
- NHS Lothian
- Department of Health, United Kingdom
|
Other |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Evidence of prion disease pathology in the Lothian population, a description of the associated clinical/pathological and epidemiological features and referral characteristics, and how this compares with other cases of prion disease.
- Description of clinical, pathological and epidemiological characteristics of patients with atypical features of dementia in the Lothian population.
- Assessment of the suitability of methods to support an extended system of enhanced CJD surveillance in the rest of the UK.
|
300 |
All |
65 Years and older (Adult, Senior) |
NCT02629640 |
15/SS/0196 |
|
January 2016 |
March 2020 |
March 2020 |
December 14, 2015 |
February 27, 2018 |
|
- CJD Research and Surveillance Unit, Western General Hospital
Edinburgh, United Kingdom
|
| 5 |
NCT00721864 |
Completed |
The Molecular Biology of Paroxysmal Nocturnal Hemoglobinuria (PNH) |
- Hemoglobinuria, Paroxysmal
|
|
Observational |
|
- University of Utah
- National Institutes of Health (NIH)
|
Other / NIH |
- Observational Model: Cohort
- Time Perspective: Prospective
|
- Identify the mutation causing the predominant clones through analysis of extracted DNA/RNA from erythroid colonies
- Reconfirmation of PrP expression in human granulocytes, hematopoietic progenitors and stem cells
- Analysis of PrP function in human long term hematopoietic stem cells
|
10 |
All |
7 Years and older (Child, Adult, Senior) |
NCT00721864 |
17790
R01HL5077-12 |
|
May 2006 |
December 2010 |
December 2010 |
July 25, 2008 |
August 9, 2011 |
|
- University of Utah
Salt Lake City, Utah, United States
|
| 6 |
NCT02951559 |
Recruiting |
SOLFAMU Study of Nasal Brushing Collected OLFActory MUcosa Samples in the Diagnosis of Human Encephalopathies |
- Encephalopathy
- HIV-encephalopathy
- Alzheimer Dementia
|
|
Interventional |
Phase 4 |
- University of Turin, Italy
|
Other |
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Diagnostic
|
- Diagnostic concordance with gold standard diagnostic procedures
- Side effects of the nasal brushing
- Cytological and immunohistochemistry examination of nasal brushing smear (neuronal abnormalities and expression of specific markers according to the different aetiologies)
- OM markers of neuronal damage and amyloid deposition
|
250 |
All |
18 Years and older (Adult, Senior) |
NCT02951559 |
SOLFAMU |
|
March 2016 |
February 2021 |
February 2021 |
November 1, 2016 |
November 1, 2016 |
|
- University of Torino
Torino, Italy
|
| 7 |
NCT02837705 |
Recruiting |
Therapeutic Antibodies Against Prion Diseases From PRNP Mutation Carriers |
|
|
Observational |
|
|
Other |
- Observational Model: Case-Control
- Time Perspective: Cross-Sectional
|
- Anti-Prion protein autoantibody levels
|
500 |
All |
1 Year to 99 Years (Child, Adult, Senior) |
NCT02837705 |
2015-0514 |
PRNP |
September 2015 |
June 2018 |
August 2018 |
July 20, 2016 |
November 13, 2017 |
|
- UCSF Memory and Aging Center
San Francisco, California, United States - Medical University Graz
Graz, Austria - University Medical Center Göttingen
Göttingen, Germany - (and 4 more...)
|
| 8 |
NCT00994045 |
Completed |
Fibrinogen as an Alternative to FFP in Aortic Surgery. |
- Coagulopathy in Patients Having Thoraco-Abdominal Aneurysm Repair
|
- Biological: Fibrinogen concentrate
- Biological: Fresh Frozen Plasma
|
Interventional |
Phase 4 |
- University of Edinburgh
- NHS Lothian
- CSL Behring
|
Other / Industry |
- Allocation: Randomized
- Intervention Model: Parallel Assignment
- Masking: Single (Participant)
- Primary Purpose: Treatment
|
- Pattern of coagulation disturbance in the conventional treatment (FFP) and fibrinogen concentrate groups.
- Proportion of patients in the fibrinogen group in whom FFP transfusion is required during surgery.
- Units of FFP transfused - during surgery and up to 24 hours after surgery.
- (and 2 more...)
|
20 |
All |
18 Years and older (Adult, Senior) |
NCT00994045 |
FIB692
EudraCT 2009-016709-41 |
|
June 2010 |
August 2013 |
|
October 14, 2009 |
January 31, 2017 |
|
- The Royal Infirmary of Edinburgh
Edinburgh, United Kingdom
|
| 9 |
NCT00104663 |
Completed |
PRION-1: Quinacrine for Human Prion Disease |
|
|
Interventional |
Not Applicable |
|
Other |
- Allocation: Non-Randomized
- Intervention Model: Single Group Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Time to death
- proportion of responders, with "responders" defined as patients showing either clinical improvement or lack of deterioration in 3 key neurological and neuropsychiatric measures
- Mini Mental State Examination (MMSE)
- (and 8 more...)
|
160 |
All |
12 Years and older (Child, Adult, Senior) |
NCT00104663 |
Version 1.1
Grant ID:71361 |
|
June 2004 |
|
March 2007 |
March 4, 2005 |
April 7, 2015 |
|
- National Prion Clinic
London, United Kingdom
|
| 10 |
NCT01063595 |
Completed
Has Results |
A Trial to Investigate the Relative Efficacy, Safety, and Tolerability of Octaplas LG Versus Octaplas SD |
- Comparison of Octaplas LG and Octaplas SD
|
- Biological: Octaplas LG
- Biological: Octaplas SD
|
Interventional |
Phase 1 |
|
Industry |
- Allocation: Randomized
- Intervention Model: Crossover Assignment
- Masking: None (Open Label)
- Primary Purpose: Treatment
|
- Recovery of the Coagulation Factors I, II, V, VII, VIII, IX, X, and XI
- Recovery of the Haemostatic Parameters Prothrombin Time, Activated Partial Thromboplastin Time, and Protein C
- Concentration of Plasmin Inhibitor
|
63 |
All |
18 Years and older (Adult, Senior) |
NCT01063595 |
LAS-203 |
|
December 2009 |
July 2010 |
July 2010 |
February 5, 2010 |
May 20, 2014 |
May 1, 2014 |
- Department of Clinical Pharmacology - Medical University Vienna
Vienna, Austria
|
| 11 |
NCT02014246 |
Recruiting |
Genetic Characterization of Movement Disorders and Dementias |
- Ataxia
- Dystonia
- Parkinson's Disease
- (and 12 more...)
|
|
Observational |
|
- National Institute on Aging (NIA)
- National Institutes of Health Clinical Center (CC)
|
NIH |
- Observational Model: Case-Control
- Time Perspective: Other
|
- Identify and characterize genetic contributions to etiology for movement disorders, such as dystonia, Parkinson's disease, and dementias, such as Alzheimer's disease, Lewy Body Dementia, frontotemporal dementia.
|
12000 |
All |
18 Years and older (Adult, Senior) |
NCT02014246 |
999903329
03-AG-N329 |
|
February 12, 2003 |
December 31, 2018 |
December 31, 2018 |
December 18, 2013 |
April 6, 2018 |
|
- National Institute of Aging, Clinical Research Unit
Baltimore, Maryland, United States
|
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