127 studies found for:    Brain and Spinal Tumors
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21 Recruiting Risk-Adapted Therapy for Young Children With Embryonal Brain Tumors, Choroid Plexus Carcinoma, High Grade Glioma or Ependymoma
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: Induction Chemotherapy;   Drug: Low-Risk Therapy;   Drug: High-Risk Therapy;   Drug: Intermediate-Risk Therapy
22 Recruiting Circulating Tumor DNA in Cerebrospinal Fluid as an Early Biomarker of Leptomeningeal Metastasis (LM)
Condition: Leptomeningeal Metastasis
Intervention:
23 Terminated Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or Refractory Solid Tumors, CNS Tumors, Lymphoma, or T-Cell Leukemia
Conditions: Childhood Atypical Teratoid/Rhabdoid Tumor;   Childhood Central Nervous System Choriocarcinoma;   Childhood Central Nervous System Germinoma;   Childhood Central Nervous System Mixed Germ Cell Tumor;   Childhood Central Nervous System Teratoma;   Childhood Central Nervous System Yolk Sac Tumor;   Childhood Choroid Plexus Tumor;   Childhood Craniopharyngioma;   Childhood Ependymoblastoma;   Childhood Grade I Meningioma;   Childhood Grade II Meningioma;   Childhood Grade III Meningioma;   Childhood Infratentorial Ependymoma;   Childhood Medulloepithelioma;   Childhood Mixed Glioma;   Childhood Oligodendroglioma;   Childhood Supratentorial Ependymoma;   Gonadotroph Adenoma;   Pituitary Basophilic Adenoma;   Pituitary Chromophobe Adenoma;   Pituitary Eosinophilic Adenoma;   Prolactin Secreting Adenoma;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Anaplastic Large Cell Lymphoma;   Recurrent Childhood Brain Stem Glioma;   Recurrent Childhood Central Nervous System Embryonal Tumor;   Recurrent Childhood Cerebellar Astrocytoma;   Recurrent Childhood Cerebral Astrocytoma;   Recurrent Childhood Ependymoma;   Recurrent Childhood Grade III Lymphomatoid Granulomatosis;   Recurrent Childhood Large Cell Lymphoma;   Recurrent Childhood Lymphoblastic Lymphoma;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Pineoblastoma;   Recurrent Childhood Small Noncleaved Cell Lymphoma;   Recurrent Childhood Spinal Cord Neoplasm;   Recurrent Childhood Subependymal Giant Cell Astrocytoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor;   Recurrent Childhood Visual Pathway and Hypothalamic Glioma;   Recurrent Childhood Visual Pathway Glioma;   Recurrent Pituitary Tumor;   Recurrent/Refractory Childhood Hodgkin Lymphoma;   T-cell Childhood Acute Lymphoblastic Leukemia;   T-cell Large Granular Lymphocyte Leukemia;   TSH Secreting Adenoma;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097;   Other: diagnostic laboratory biomarker analysis;   Other: pharmacological study;   Drug: dexamethasone
24 Completed FR901228 in Treating Children With Refractory or Recurrent Solid Tumors or Leukemia
Conditions: Blastic Phase Chronic Myelogenous Leukemia;   Childhood Central Nervous System Germ Cell Tumor;   Childhood Choroid Plexus Tumor;   Childhood Chronic Myelogenous Leukemia;   Childhood Craniopharyngioma;   Childhood Grade I Meningioma;   Childhood Grade II Meningioma;   Childhood Grade III Meningioma;   Childhood High-grade Cerebral Astrocytoma;   Childhood Infratentorial Ependymoma;   Childhood Low-grade Cerebral Astrocytoma;   Childhood Spinal Cord Neoplasm;   Childhood Supratentorial Ependymoma;   Recurrent Childhood Acute Lymphoblastic Leukemia;   Recurrent Childhood Acute Myeloid Leukemia;   Recurrent Childhood Brain Stem Glioma;   Recurrent Childhood Cerebellar Astrocytoma;   Recurrent Childhood Cerebral Astrocytoma;   Recurrent Childhood Ependymoma;   Recurrent Childhood Medulloblastoma;   Recurrent Childhood Supratentorial Primitive Neuroectodermal Tumor;   Recurrent Childhood Visual Pathway and Hypothalamic Glioma;   Refractory Chronic Lymphocytic Leukemia;   Relapsing Chronic Myelogenous Leukemia;   Unspecified Childhood Solid Tumor, Protocol Specific
Intervention: Drug: romidepsin
25 Active, not recruiting Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma
Conditions: Childhood Cerebellar Anaplastic Astrocytoma;   Childhood Cerebral Anaplastic Astrocytoma;   Childhood Spinal Cord Neoplasm;   Untreated Childhood Brain Stem Glioma;   Untreated Childhood Cerebral Astrocytoma
Interventions: Drug: Vorinostat;   Biological: Bevacizumab;   Drug: Temozolomide
26 Completed Cyberknife Precision Radiation Delivery System for Tumors of the Spine
Conditions: Spinal Cord Cancer;   Brain (Nervous System) Cancers
Intervention: Procedure: Stereotactic radiosurgery
27 Completed Alpha-Lipoic Acid in Preventing Peripheral Neuropathy in Patients Receiving Chemotherapy for Cancer
Conditions: Neurotoxicity;   Unspecified Adult Solid Tumor, Protocol Specific;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: alpha-lipoic acid;   Other: placebo
28 Terminated MK0752 in Treating Young Patients With Recurrent or Refractory CNS Cancer
Condition: Brain and Central Nervous System Tumors
Intervention: Drug: MK-0752
29 Suspended PTC299 in Treating Young Patients With Refractory or Recurrent Primary Central Nervous System Tumors
Condition: Brain and Central Nervous System Tumors
Intervention: Drug: VEGF inhibitor PTC299
30 Completed DepoCyt Therapy in Patients With Neoplastic Meningitis From Lymphoma or a Solid Tumor
Condition: Meningeal Neoplasms
Interventions: Drug: Intrathecal (injected into the spinal fluid) DepoCyt;   Drug: Intrathecal methotrexate;   Drug: Intrathecal cytarabine (also known as ara-C)
31 Completed Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment
Conditions: Brain Tumor;   Central Nervous System Tumors;   Cachexia;   Leukemia;   Lymphoma;   Myelodysplastic Syndromes;   Myelodysplastic/Myeloproliferative Diseases;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: cyproheptadine hydrochloride;   Drug: megestrol acetate
32 Terminated Study Bendamustine Concurrent Whole Brain Radiation Brain Metastases From Solid Tumors
Condition: Brain Metastases
Intervention: Drug: Bendamustine
33 Completed Valproic Acid in Treating Young Patients With Recurrent or Refractory Solid Tumors or CNS Tumors
Conditions: Brain and Central Nervous System Tumors;   Unspecified Childhood Solid Tumor, Protocol Specific
Intervention: Drug: valproic acid
34 Withdrawn Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is Recurrent or Does Not Respond to Treatment
Conditions: Brain and Central Nervous System Tumors;   Leukemia;   Lymphoma;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: talotrexin;   Procedure: chemotherapy
35 Active, not recruiting Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors
Conditions: Brain and Central Nervous System Tumors;   Childhood Germ Cell Tumor;   Extragonadal Germ Cell Tumor;   Kidney Cancer;   Liver Cancer;   Lymphoma;   Neuroblastoma;   Ovarian Cancer;   Sarcoma;   Testicular Germ Cell Tumor;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: carboplatin;   Drug: dasatinib;   Drug: etoposide phosphate;   Drug: ifosfamide;   Genetic: microarray analysis;   Genetic: western blotting;   Other: immunohistochemistry staining method;   Other: laboratory biomarker analysis;   Procedure: therapeutic conventional surgery;   Radiation: radiation therapy
36 Recruiting Crizotinib in Treating Young Patients With Relapsed or Refractory Solid Tumors or Anaplastic Large Cell Lymphoma
Conditions: Brain and Central Nervous System Tumors;   Lymphoma;   Neuroblastoma;   Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: crizotinib;   Other: pharmacogenomic studies;   Other: pharmacological study
37 Completed Direct Injection of Alcohol for the Treatment of Spinal Tumors
Conditions: Hemangioma;   Neoplasm Metastasis;   Spinal Neoplasm
Intervention:
38 Active, not recruiting Radiation Therapy or Combination Chemotherapy in Treating Patients With Clinically or Radiologically Progressive Low-Grade Gliomas
Condition: Primary Central Nervous System Neoplasms
Interventions: Drug: vincristine, carboplatin;   Drug: vincristine, carboplatin, etoposide;   Radiation: radiation therapy
39 Completed Chemotherapy and Radiation Therapy After Surgery in Treating Children With Newly Diagnosed Astrocytoma, Glioblastoma Multiforme, Gliosarcoma, or Diffuse Intrinsic Pontine Glioma
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide;   Procedure: adjuvant therapy;   Radiation: radiation therapy
40 Unknown  Polyvinylpyrrolidone-Sodium Hyaluronate Gel in Reducing Pain From Oral Mucositis in Young Patients With Cancer
Conditions: Brain and Central Nervous System Tumors;   Chordoma;   Kidney Cancer;   Leukemia;   Lymphoma;   Mucositis;   Neuroblastoma;   Pain;   Sarcoma;   Unspecified Childhood Solid Tumor, Protocol Specific
Intervention: Drug: polyvinylpyrrolidone-sodium hyaluronate gel

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