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231 studies found for:    BRCA1
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Rank Status Study
1 Recruiting Written Genetic Counseling and Mutation Analysis of BRCA1 and BRCA2 to Patients With Breast Cancer
Condition: Hereditary Breast Cancer
Intervention: Genetic: Germline genetic testing of BRCA1 and BRCA2
2 Unknown  The Potential for Oral Diindolylmethane (DIM) Supplementation to Increase the Production of the BRCA1 Protein in BRCA1 Mutation Carriers
Condition: Breast Cancer
Intervention: Dietary Supplement: Diindolylmethane (DIM)
3 Recruiting The Registration Program of BRCA1/2 Gene
Condition: Breast Cancer
Intervention: Genetic: NGS test
4 Recruiting BRCA1 and BRCA2 Mutation in Romanian Population: a Study of Genotype - Phenotype Correlation at Diagnosis With Prospective Disease Outcome and Survival
Condition: To Determine the Prevalence, Penetrance of BRCA1 and BRCA2 Mutations in Romanian Womens With Breast or Ovarian Cancer
Interventions: Genetic: NGS BRCA 1 and BRCA 2 full sequencing;   Genetic: Multiplex ligation-dependent probe amplification (MPLA) BRCA1 BRCA2
5 Recruiting Circulating Tumor DNA and Follow-up of BRCA1 Mutation Carriers (CirCa 01)
Condition: Women With BRCA1 Germline Deleterious Mutation
Intervention: Procedure: Blood sampling
6 Completed BRCA1 Haploinsufficiency and Gene Expression
Condition: BRCA1 Mutations
7 Completed A Qualitative Exploration of the Impact of Positive BRCA1/2 Mutation Status on the Lives of Young Women
Conditions: Breast Cancer;   BRCA1 Gene;   BRCA2 Gene
8 Recruiting Early Salpingectomy (Tubectomy) With Delayed Oophorectomy in BRCA1/2 Gene Mutation Carriers
Conditions: BRCA1 Gene Mutation;   BRCA2 Gene Mutation;   Ovarian Cancer
Interventions: Procedure: Salpingectomy with delayed oophorectomy;   Procedure: Risk-reducing salpingo-oophorectomy
9 Completed Open-Label,Non-Randomized Trial of Cisplatin Chemotherapy in BRCA1-Positive Metastatic Breast Cancer Patients
Conditions: BRCA1 Mutation;   Metastatic Breast Cancer
Intervention: Drug: Cisplatin
10 Active, not recruiting Letrozole in Preventing Breast Cancer in Postmenopausal Women With a BRCA1 or BRCA2 Mutation
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Drug: letrozole;   Drug: Placebo
11 Unknown  Cisplatin-monotherapy in the Treatment of BRCA1 Positive Breast Cancer Patients in Poland
Conditions: BRCA1 Mutation;   Breast Cancer Invasive Nos
Intervention: Drug: Neoadjuvant Cisplatin Chemotherapy
12 Recruiting The IMPACT Study - Identification of Men With a Genetic Predisposition to ProstAte Cancer
Condition: Prostate Cancer in BRCA1 and BRCA2 Carriers
Interventions: Behavioral: PSA test;   Procedure: Prostate Biopsy
13 Recruiting COsegregation of VARiants in the BRCA1/2 Genes
Conditions: Genes, BRCA1;   Genes, BRCA2;   Ovarian Neoplasms;   Breast Neoplasms
Intervention: Genetic: salivary kit
14 Unknown  Study With Trabectedin in BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype Ovarian Cancer
Condition: BRCA1 and BRCA2 Mutation Carrier and BRCAness Phenotype
Intervention: Drug: Trabectedin
15 Recruiting Standard Genetic Counseling With or Without a Decision Guide in Improving Communication Between Mothers Undergoing BRCA1/2 Testing and Their Minor-Age Children
Conditions: Breast Cancer;   Hereditary Breast/Ovarian Cancer (brca1, brca2)
Interventions: Other: counseling intervention;   Other: educational intervention;   Other: survey administration;   Behavioral: psychosocial assessment and care;   Behavioral: supportive care
16 Unknown  Studying Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: brca1 Mutation Carrier;   brca2 Mutation Carrier;   Breast Cancer
Interventions: Genetic: DNA analysis;   Genetic: mutation analysis;   Genetic: polymorphism analysis;   Other: laboratory biomarker analysis;   Procedure: evaluation of cancer risk factors
17 Recruiting Capturing BRCA1/2 Mutational Status in Women With High Grade Serous Ovarian Cancer and Impact on Clinical Outcome.
Condition: Ovarian Cancer
Intervention: Genetic: BRCA genetic data
18 Unknown  Individualized Chemotherapy Based on BRCA1 and RRM1 mRNA for Advanced Non-small Cell Lung Cancer (NSCLC)
Condition: Non-small Cell Lung Cancer
Interventions: Drug: Gemcitabine, Docetaxel, CPT-11,Cisplatin;   Drug: gemcitabine/cisplatin
19 Recruiting Screening for PDAC in BRCA1/2 Patients
Condition: Pancreatic Cancer
Intervention: Device: prophylactic endoscopic ultrasound
20 Withdrawn Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers
Conditions: BRCA1 Mutation Carrier;   BRCA2 Mutation Carrier;   Breast Carcinoma
Intervention: Other: Laboratory Biomarker Analysis

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