87 studies found for:    Alpha-1 Antitrypsin Deficiency
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Rank Status Study
21 Completed
Has Results
Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Biological: Alpha1-Proteinase Inhibitor
22 Recruiting Safety and Pharmacokinetics of Alpha-1 MP in Patients With Alpha1-Antitrypsin Deficiency
Condition: Alpha1-Antitrypsin Deficiency
Intervention: Biological: Alpha-1 MP
23 Terminated Study of Genotype and Phenotype in Patients With Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention:
24 Completed Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: Aerosolized, Recombinant Alpha 1-Antitrypsin
25 Recruiting Alpha-1 Foundation Research Registry
Condition: Alpha 1-Antitrypsin Deficiency
Intervention:
26 Completed Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: Kamada-API
27 Completed Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation.
Condition: Alpha 1 Antitrypsin Deficiency
Intervention: Drug: Alpha-1 Antitrypsin (human)
28 Completed
Has Results
The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: alpha-1 proteinase inhibitor (human)
29 Active, not recruiting A Study of an Investigational Drug, ALN-AAT, in Healthy Adult Subjects and Patients With ZZ Type Alpha-1 Antitrypsin Deficiency Liver Disease
Condition: Antitrypsin Deficiency Liver Disease
Interventions: Drug: ALN-AAT;   Drug: Sterile Normal Saline (0.9% NaCl)
30 Completed
Has Results
Extension Study of Zemaira® i.v. Administration in Subjects With Emphysema Due to alpha1-proteinase Inhibitor Deficiency.
Conditions: Emphysema;   Alpha 1-proteinase Inhibitor Deficiency
Intervention: Biological: Alpha1- proteinase inhibitor [human]
31 Completed
Has Results
Zemaira in Subjects With Emphysema Due to Alpha1-Proteinase Inhibitor Deficiency
Conditions: Alpha1-proteinase Inhibitor Deficiency;   Emphysema
Interventions: Biological: Alpha1-proteinase inhibitor;   Other: Placebo
32 Completed A Study to Assess Safety and PK of Liquid Alpha1-Proteinase Inhibitor (Human) in Treating Alpha1-Antitrypsin Deficiency
Condition: Alpha1-antitrypsin Deficiency
Interventions: Biological: Liquid Alpha1-PI;   Biological: Prolastin-C
33 Unknown  Lung Volume Reduction Coils for Emphysema in Alpha-1 Antitrypsin Deficiency
Conditions: Alpha-1-Antitrypsin Deficiency;   Chronic Obstructive Lung Disease;   Emphysema
Intervention: Device: Lung Volume Reduction Coil (PneumrX Inc.)
34 Completed
Has Results
Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)
Condition: Alpha 1-Antitrypsin Deficiency
Interventions: Drug: Alpha1-Proteinase Inhibitor (Human);   Drug: Albumin (Human) 20%, United States Pharmacopeia (USP)
35 Unknown  Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema
Conditions: Alpha 1-Antitrypsin Deficiency;   Emphysema
Intervention:
36 Withdrawn Safety, Tolerability and Effect of ARC-AAT Injection on Circulating and Intrahepatic Alpha-1 Antitrypsin Levels
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Drug: ARC-AAT Injection
37 Completed Phase II, Safety and ELF Study of "Kamada-API for Inhalation"
Condition: Alpha-1 Antitrypsin Deficiency
Interventions: Biological: Kamada-API for Inhalation, 80mg;   Drug: Placebo;   Biological: Kamada-API for Inhalation, 160mg
38 Active, not recruiting Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Genetic: rAAV2-CB-hAAT Gene Vector
39 Recruiting Efficacy and Safety of Alpha1-Proteinase Inhibitor (Human), Modified Process (Alpha-1 MP) in Subjects With Pulmonary Emphysema Due to Alpha1 Antitrypsin Deficiency (AATD)
Condition: Pulmonary Emphysema in Alpha-1 PI Deficiency
Interventions: Biological: Alpha1-proteinase inhibitor (human), modified process (Alpha-1 MP);   Other: 0.9% Sodium Chloride for Injection, USP
40 Recruiting Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort
Condition: Children With a Deficiency of Alpha-1 Antitrypsin
Intervention: Other: blood sampling

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Study has passed its completion date and status has not been verified in more than two years.