67 studies found for:    Alpha-1 Antitrypsin Deficiency
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Rank Status Study
21 Completed
Has Results
Efficacy and Safety Study of Augmentation Therapy With ARALAST Fraction IV-1 (Human Alpha 1 - Proteinase Inhibitor)
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Biological: Alpha1-Proteinase Inhibitor
22 Completed
Has Results
Alpha-1-Antitrypsin (AAT) To Treat Emphysema In AAT-Deficient Patients (EXACTLE)
Condition: Alpha 1-Antitrypsin Deficiency
Interventions: Drug: Alpha1-Proteinase Inhibitor (Human);   Drug: Albumin (Human) 20%, United States Pharmacopeia (USP)
23 Recruiting Effect of Double Dose of Alpha 1-antitrypsin Augmentation Therapy on Lung Inflammation.
Condition: Alpha 1 Antitrypsin Deficiency
Intervention: Drug: Alpha-1 Antitrypsin (human)
24 Completed
Has Results
The Safety and Tolerability of Alpha-1 Modified Process (MP) In Subjects With Alpha-1-antitrypsin (AAT) Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: alpha-1 proteinase inhibitor (human)
25 Unknown  Management of Patients With Alpha-1 Antitrypsin Deficiency Associated Emphysema
Conditions: Alpha 1-Antitrypsin Deficiency;   Emphysema
Intervention:
26 Completed Study of the Effect of Aerosolized, Recombinant Alpha 1-Antitrypsin on Epithelial Lining Fluid Analytes in Subjects With Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: Aerosolized, Recombinant Alpha 1-Antitrypsin
27 Completed Phase II/III Study of an Alpha-1 Proteinase Inhibitor (Kamada-API) in Individuals With Alpha-1 Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: Kamada-API
28 Recruiting Alpha-1 Foundation Research Registry
Condition: Alpha 1-Antitrypsin Deficiency
Intervention:
29 Completed Therapy to Elevate CD4 Counts in HIV-1 Disease
Condition: HIV Disease
Intervention: Biological: alpha-1-Proteinase Inhibitor
30 Recruiting Lung Disease and Its Affect on the Work of White Blood Cells in the Lungs
Conditions: Alpha-1 Antitrypsin Deficiency;   AAT Deficiency;   AATD;   Cystic Fibrosis (CF)
Interventions: Procedure: History and physical exam.;   Procedure: Blood draw.;   Procedure: Pulmonary function testing.;   Drug: Albuterol inhaler.
31 Completed Alpha1-antitrypsin Deficiency Registry
Conditions: Lung Diseases;   Emphysema;   Alpha-1 Antitrypsin Deficiency;   Chronic Obstructive Pulmonary Disease
Intervention:
32 Recruiting A Study to Assess Safety and PK of Liquid Alpha1-Proteinase Inhibitor (Human) in Treating Alpha1-Antitrypsin Deficiency
Condition: Alpha1-antitrypsin Deficiency
Interventions: Biological: Liquid Alpha1-PI;   Biological: Prolastin-C
33 Recruiting Study of Human Plasma-Derived Alpha1-Proteinase Inhibitor in Subjects With New-Onset Type 1 Diabetes Mellitus
Condition: Type 1 Diabetes Mellitus
Interventions: Biological: 180 mg/kg Alpha1-PI;   Biological: 90 mg/kg Alpha1-PI;   Biological: Placebo
34 Recruiting Phase II, Safety and ELF Study of "Kamada-API for Inhalation"
Condition: Alpha-1 Antitrypsin Deficiency
Interventions: Biological: Kamada-API for Inhalation, 80mg;   Drug: Placebo;   Biological: Kamada-API for Inhalation, 160mg
35 Active, not recruiting Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Genetic: rAAV2-CB-hAAT Gene Vector
36 Completed Experimental Gene Transfer Procedure to Treat Alpha 1-Antitrypsin Deficiency
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Biological: rAAV1-CB-hAAT
37 Recruiting Alpha-1 Coded Testing(ACT) Study
Condition: Alpha-1 Antitrypsin Deficiency
Intervention: Procedure: Alpha-1 Antitrypsin Genotype
38 Recruiting Polygen Defi-Alpha: Genetic Polymorphisms Study in Children With Alpha-1 Antitrypsin Deficiency, Included in the DEFI-ALPHA Cohort
Condition: Children With a Deficiency of Alpha-1 Antitrypsin
Intervention: Other: blood sampling
39 Completed 4-PBA: Will it Increase the Level of Alpha 1-Antitrypsin(AAT) in Persons With AAT Deficiency?
Condition: Alpha 1-Antitrypsin Deficiency
Intervention: Drug: 4-PBA
40 Terminated
Has Results
Aralast alpha1-proteinase Inhibitor Surveillance Study
Condition: Alpha 1-Antitrypsin (AAT) Deficiency
Intervention: Drug: ARALAST Alpha1-Proteinase Inhibitor

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Indicates status has not been verified in more than two years