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28 studies found for:    AMG479
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Rank Status Study
21 Completed QUILT-2.018: Safety & Efficacy of FOLFIRI With AMG 479 or AMG 655 vs FOLFIRI Alone in KRAS-mutant Metastatic Colorectal Carcinoma
Condition: Metastatic Colorectal Cancer
Interventions: Other: FOLFIRI;   Biological: AMG 655;   Other: Placebo;   Biological: AMG 479
22 Completed Ganitumab and Gemcitabine Hydrochloride Followed by Radiation Therapy, Ganitumab, Capecitabine, and Maintenance Therapy in Treating Patients With Locally Advanced Cancer of the Pancreas
Condition: Pancreatic Cancer
Interventions: Biological: ganitumab;   Drug: capecitabine;   Drug: gemcitabine hydrochloride;   Radiation: 3-dimensional conformal radiation therapy
23 Completed QUILT-2.015: A Study of AMG 479 With Exemestane or Fulvestrant in Postmenopausal Women With Hormone Receptor Positive Locally Advanced or Metastatic Breast Cancer
Conditions: Breast Cancer;   Breast Tumors;   Metastatic Cancer
Intervention: Drug: AMG 479 or placebo administered with either exemestane or fulvestrant
24 Completed AMG-479 in Treating Patients With Advanced Solid Tumors or Non-Hodgkin Lymphoma
Conditions: Lymphoma;   Prostate Cancer;   Sarcoma;   Small Intestine Cancer;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Biological: ganitumab;   Other: laboratory biomarker analysis;   Other: pharmacological study;   Procedure: biopsy
25 Recruiting Combination Chemotherapy With or Without Ganitumab in Treating Patients With Newly Diagnosed Metastatic Ewing Sarcoma
Conditions: Metastatic Ewing Sarcoma;   Metastatic Malignant Neoplasm in the Bone;   Metastatic Malignant Neoplasm in the Bone Marrow;   Metastatic Malignant Neoplasm in the Lung;   Metastatic Peripheral Primitive Neuroectodermal Tumor of Bone;   Peripheral Primitive Neuroectodermal Tumor of Soft Tissues
Interventions: Drug: Cyclophosphamide;   Drug: Doxorubicin Hydrochloride;   Drug: Etoposide;   Radiation: External Beam Radiation Therapy;   Biological: Ganitumab;   Drug: Ifosfamide;   Other: Laboratory Biomarker Analysis;   Other: Pharmacological Study;   Radiation: Stereotactic Radiosurgery;   Procedure: Therapeutic Surgical Procedure;   Drug: Vincristine Sulfate
26 Completed
Has Results
Study to Evaluate Mechanisms of Acquired Resistance to Panitumumab
Condition: Metastatic Colorectal Cancer
Interventions: Biological: Panitumumab;   Biological: Ganitumab;   Drug: Irinotecan
27 Withdrawn Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously Untreated Metastatic Pancreatic Cancer
Condition: Pancreatic Cancer
Interventions: Biological: ganitumab;   Drug: fluorouracil;   Drug: irinotecan hydrochloride;   Drug: leucovorin calcium;   Drug: oxaliplatin;   Other: placebo;   Other: questionnaire administration
28 Recruiting I-SPY 2 TRIAL: Neoadjuvant and Personalized Adaptive Novel Agents to Treat Breast Cancer
Conditions: Breast Neoplasms;   Breast Cancer;   Breast Tumors
Interventions: Drug: Standard Therapy;   Drug: AMG 386 with or without Trastuzumab;   Drug: AMG 479 (Ganitumab) plus Metformin;   Drug: MK-2206 with or without Trastuzumab;   Drug: AMG 386 and Trastuzumab;   Drug: T-DM1 and Pertuzumab;   Drug: Pertuzumab and Trastuzumab;   Drug: Ganetespib;   Drug: ABT-888;   Drug: Neratinib;   Drug: PLX3397;   Drug: Pembrolizumab;   Drug: Talazoparib plus Irinotecan;   Drug: Patritumab and Trastuzumab

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Study has passed its completion date and status has not been verified in more than two years.