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68 studies found for:    Open Studies | GVHD AND chronic
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Rank Status Study
1 Recruiting Multiple Donor Treg DLI for Severe Refractory Chronic GVHD
Condition: Chronic Graft Versus Host Disease
Intervention: Biological: T reg DLI
2 Recruiting Continuous Alloreactive T Cell Depletion and Regulatory T Cell Expansion for the Treatment of Steroid-refractory or Dependent Chronic GVHD
Condition: Chronic GVHD After HCT for Cancer or Immune Disease
Intervention: Other: Autologous peripheral blood mononuclear cells ex vivo depleted for reactive T cells, using TH9402 based photodynamic therapy, in a final formulation of 10% DMSO, 30% autologous plasma in PlasmaLyte.
3 Recruiting A Phase II Trial of Low-Dose Interleukin-2 (IL-2) Added to Extra-Corporeal Photopheresis for Steroid-Refractory Chronic Graft-versus-Host-Disease
Condition: Chronic Graft-versus-host-disease
Interventions: Procedure: Extracorporeal Photopheresis (ECP);   Drug: Interleukin-2
4 Recruiting Treatment of Chronic Graft-Versus-Host Disease With Mesenchymal Stromal Cells
Condition: Chronic Graft-Versus-Host Disease
Intervention: Biological: Mesenchymal Stromal Cells
5 Recruiting Trial of Regulatory T-cells Plus Low-Dose Interleukin-2 for Steroid-Refractory Chronic Graft-versus-Host-Disease
Conditions: Chronic Graft Versus Host Disease;   Chronic GVHD;   Complications of Organ Transplant Stem Cells
Interventions: Other: Treg-enriched infusion;   Drug: Interleukin-2
6 Recruiting Ofatumumab as Primary Therapy of Chronic Graft Versus Host Disease
Condition: Chronic Graft Versus Host Disease
Intervention: Drug: Ofatumumab
7 Recruiting A Phase I Study of Abatacept in the Treatment of Patients With Steroid Refractory Chronic Graft Versus Host Disease (cGVHD)
Condition: Chronic Graft Versus Host Disease
Intervention: Drug: Abatacept
8 Recruiting Ibrutinib in Combination With Corticosteroids Versus Placebo in Combination With Corticosteroids in Subjects With New Onset Chronic Graft Versus Host Disease (cGVHD)
Condition: Chronic Graft Versus Host Disease
Interventions: Drug: ibrutinib;   Drug: Placebo;   Drug: Prednisone
9 Recruiting An Open Label Phase II Trial of Topical Sirolimus for the Treatment of Refractory Oral Chronic Graft-versus-Host-Disease
Conditions: Chronic Graft-versus-Host-Disease;   Oral Mucosal Disease Due to Graft-versus-host Disease
Intervention: Drug: Sirolimus
10 Recruiting Efficacy and Tolerability of Entospletinib in Combination With Systemic Corticosteroids as First-Line Therapy in Adults With Chronic Graft Versus Host Disease (cGVHD)
Condition: Chronic Graft Versus Host Disease
Interventions: Drug: Entospletinib;   Drug: Placebo;   Drug: Systemic Corticosteroids
11 Recruiting Carfilzomib in Treating Patients With Chronic Graft-Versus-Host Disease
Condition: Chronic Graft Versus Host Disease
Interventions: Drug: Carfilzomib;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
12 Recruiting Predictive Biomarkers For Pediatric Chronic Graft-Versus-Host Disease
Condition: Chronic Graft vs Host Disease
Intervention:
13 Recruiting Study of Baricitinib, a JAK1/2 Inhibitor, in Chronic Graft-Versus-Host Disease After Allogeneic Hematopoietic Stem Cell Transplantation
Conditions: Chronic Graft vs Host Disease;   Chronic Graft-Versus-Host Disease
Intervention: Drug: Baricitinib
14 Recruiting Evaluation of the Diagnostic Value of PET (18F-FDG) in Chronic Graft Versus Host Disease (cGVH)
Condition: Chronic Graft Versus Host Disease
Intervention: Procedure: PET (18-FDG)
15 Recruiting Extracorporeal Photopheresis Using Theraflex ECP™ for Patients With Refractory Chronic Graft Versus Host Disease (cGVHD)
Condition: Refractory Chronic Graft Versus Host Disease (cGVHD)
Intervention: Device: Photopheresis Theraflex ECP™
16 Recruiting Extracorporeal Photopheresis and Low Dose Aldesleukin in Treating Patients With Steroid Refractory Chronic Graft-Versus-Host Disease
Condition: Chronic Graft Versus Host Disease
Interventions: Biological: Aldesleukin;   Procedure: Extracorporeal Photopheresis;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment
17 Recruiting Treatment of Chronic Graft Versus Host Disease With Arsenic Trioxide
Conditions: Chronic Graft-Versus-Host Disease;   Immune System Diseases
Intervention: Drug: Arsenic Trioxide Injectable Solution
18 Recruiting Ixazomib Citrate in Treating Patients With Chronic Graft-versus-Host Disease
Condition: Chronic Graft Versus Host Disease
Interventions: Drug: Ixazomib Citrate;   Other: Laboratory Biomarker Analysis;   Other: Quality-of-Life Assessment;   Other: Questionnaire Administration
19 Recruiting Factors Determining Outcomes in Patients With Graft-Versus-Host Disease
Condition: Chronic Graft vs Host Disease
Intervention:
20 Recruiting Dendritic Cells in Patients With Acute or Chronic Skin Graft Versus Host Disease
Conditions: Acute Graft-versus-host Disease;   Acute GVHD;   Chronic Graft-versus-host Disease;   Chronic GVHD
Interventions: Procedure: Skin punch biopsy;   Procedure: Peripheral blood draw

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Study has passed its completion date and status has not been verified in more than two years.