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41 studies found for:    imetelstat
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Rank Status Study
1 Completed Imetelstat Sodium in Treating Younger Patients With Recurrent or Refractory Brain Tumors
Conditions: Anaplastic Astrocytoma;   Anaplastic Ependymoma;   Astrocytoma, Grade II;   Ependymoma;   Giant Cell Glioblastoma;   Glioblastoma;   Gliosarcoma;   Oligodendroglioma;   Brainstem Tumors
Intervention: Drug: imetelstat sodium
2 Active, not recruiting Imetelstat Sodium in Treating Patients With Primary or Secondary Myelofibrosis
Conditions: Primary Myelofibrosis;   Secondary Myelofibrosis;   Myeloid Malignancies
Intervention: Drug: Imetelstat
3 Suspended Study to Evaluate Activity of 2 Dose Levels of Imetelstat in Participants With Intermediate-2 or High-Risk Myelofibrosis (MF) Previously Treated With Janus Kinase (JAK) Inhibitor
Condition: Primary Myelofibrosis
Interventions: Drug: Imetelstat 9.4 milligram/kilogram (mg/kg);   Drug: Imetelstat 4.7 mg/kg
4 Completed Open Label Study With Imetelstat to Determine Effect of Imetelstat in Patients w/ Previously Treated Multiple Myeloma
Condition: Multiple Myeloma
Interventions: Drug: Imetelstat (7.5 mg/kg);   Drug: lenalidomide standard of care;   Drug: Imetelstat (9.4 mg/kg)
5 Withdrawn Imetelstat Sodium in Treating Younger Patients With Relapsed or Refractory Solid Tumors
Conditions: Childhood Hepatoblastoma;   Previously Treated Childhood Rhabdomyosarcoma;   Recurrent Childhood Liver Cancer;   Recurrent Childhood Rhabdomyosarcoma;   Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor;   Recurrent Neuroblastoma;   Recurrent Osteosarcoma
Interventions: Drug: imetelstat sodium;   Other: laboratory biomarker analysis
6 Recruiting Study to Evaluate Imetelstat (JNJ-63935937) in Subjects With International Prognostic Scoring System (IPSS) Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)
Condition: Myelodysplastic Syndromes
Interventions: Drug: Imetelstat;   Drug: Placebo
7 Completed Imetelstat as Maintenance Therapy After Initial Induction Chemotherapy in Non-small Cell Lung Cancer (NSCLC)
Condition: Non-small Cell Lung Cancer
Interventions: Drug: imetelstat;   Drug: Bevacizumab
8 Completed Open Label Study to Evaluate the Activity of Imetelstat in Patients With Essential Thrombocythemia or Polycythemia Vera
Conditions: Essential Thrombocythemia;   Polycythemia Vera
Intervention: Drug: Imetelstat
9 Withdrawn Imetelstat Given Intravenously Alone and With Standard 13-Cis-Retinoic Acid in Children With Neuroblastoma
Condition: Neuroblastoma
Intervention: Drug: Imetelstat
10 Completed
Has Results
AMG 706 and Octreotide in Treating Patients With Low-Grade Neuroendocrine Tumors
Conditions: Gastrointestinal Carcinoid Tumor;   Islet Cell Tumor;   Neoplastic Syndrome
Interventions: Drug: AMG 706;   Drug: octreotide
11 Completed Imetelstat in Combination With Paclitaxel (With or Without Bevacizumab) in Patients With Locally Recurrent or Metastatic Breast Cancer
Condition: Locally Recurrent or Metastatic Breast Cancer
Interventions: Drug: Imetelstat sodium;   Drug: Bevacizumab;   Drug: Paclitaxel
12 Terminated An Open Label Treatment Extension Study of AMG 706
Condition: Solid Tumors
Intervention: Drug: AMG 706
13 Completed Evaluate the Efficacy of AMG 706 to Treat Advanced Gastrointestinal Stromal Tumors
Condition: Advanced Gastrointestinal Stromal Tumor
Intervention: Drug: AMG 706
14 Withdrawn Imetelstat for Children With Refractory or Recurrent Solid Tumors and Lymphoma
Conditions: Solid Tumors;   Lymphoma
Intervention: Drug: Imetelstat
15 Terminated Study of Motesanib (AMG 706) in Combination With Paclitaxel and Carboplatin for Advanced Non-Squamous Non-Small Cell Lung Cancer
Condition: Carcinoma, Non-Small-Cell Lung
Interventions: Drug: Motesanib;   Drug: Placebo;   Drug: Paclitaxel;   Drug: Carboplatin
16 Completed AMG 706 in Treating Patients With Persistent or Recurrent Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer
Conditions: Fallopian Tube Cancer;   Ovarian Cancer;   Primary Peritoneal Cavity Cancer
Intervention: Drug: motesanib diphosphate
17 Completed Single Dose Study of [14C]-Labelled AMG 706 in Patients With Advanced Solid Tumors
Condition: Advanced Solid Tumors
Intervention: Drug: AMG 706
18 Completed
Has Results
Study to Evaluate Motesanib With or Without Carboplatin/Paclitaxel or Panitumumab in the Treatment of Patients With Advanced Non-Small Cell Lung Cancer (NSCLC)
Conditions: Lung Cancer;   Non-Small Cell Lung Cancer
Interventions: Biological: Panitumumab;   Drug: Motesanib diphosphate;   Drug: Paclitaxel;   Drug: Carboplatin
19 Completed Study of GRN163L With Paclitaxel and Carboplatin in Patients With Advanced or Metastatic Non Small Cell Lung Cancer
Condition: Lung Cancer
Intervention: Drug: Imetelstat Sodium (GRN163L)
20 Completed Study Evaluating AMG 706 in Subjects With Advanced Solid Tumors
Condition: Tumors
Interventions: Drug: Anti-angiogenesis;   Drug: AMG 706

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Study has passed its completion date and status has not been verified in more than two years.