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48 studies found for:    4-Phenylbutyrate
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Rank Status Study
1 Active, not recruiting Phenylbutyrate Therapy for Maple Syrup Urine Disease
Condition: Maple Syrup Urine Disease
Interventions: Drug: Phenylbutyrate;   Drug: Placebo powder
2 Completed
Has Results
Dose-Escalation Safety Study of HPN-100 to Treat Urea Cycle Disorders
Condition: Urea Cycle Disorders
Interventions: Drug: HPN-100;   Drug: BUPHENYL®
3 Completed
Has Results
Efficacy and Safety of HPN-100 for the Treatment of Adults With Urea Cycle Disorders
Condition: Urea Cycle Disorders
Interventions: Drug: HPN-100;   Drug: Buphenyl (NaPBA)
4 Completed
Has Results
Arginine and Buphenyl in Patients With Argininosuccinic Aciduria (ASA), a Urea Cycle Disorder
Conditions: Argininosuccinic Aciduria;   Amino Acid Metabolism, Inborn Errors;   Urea Cycle Disorders
Interventions: Drug: Sodium Phenylbutyrate;   Drug: Arginine
5 Completed A Study of Glyceryl Tri-(4-phenylbutyrate) (GT4P)
Condition: Healthy
Interventions: Drug: HPN-100;   Drug: Ammonul;   Drug: Buphenyl
6 Completed Comparative Efficacy of Phenylbutyrate (PBA) vs. Benzoate in Urea Cycle Disorders
Condition: UCDs (The Data May be Helpful in the Treatment of UCDs.)
Interventions: Drug: Sodium Benzoate;   Drug: Sodium Phenylbutyrate;   Drug: Phenylbutyrate and Benzoate
7 Withdrawn Pilot Study of Safety and Efficacy of Sodium Phenylbutyrate in Spinocerebellar Ataxia Type 3
Condition: Spinocerebellar Ataxia Type 3
Interventions: Drug: Placebo;   Drug: Sodium Phenylbutyrate
8 Completed Mechanism of Fatty Acid-induced Impairment of Glucose-simulated Insulin Secretion - Effect of Buphenyl
Conditions: Diabetes;   Insulin Resistance
Interventions: Drug: sodium phenylbutyrate;   Drug: Placebo
9 Active, not recruiting Phenylbutyrate Response as a Biomarker for Alpha-synuclein Clearance From the Brain
Condition: Parkinson's Disease
Intervention: Drug: Glycerol Phenylbutyrate
10 Completed Clinical Trial of Phenylbutyrate and Vitamin D in Tuberculosis (TB)
Condition: Pulmonary Tuberculosis
Interventions: Drug: Active Sodium Phenylbutyrate and active cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus active cholecalciferol;   Drug: Active Sodium Phenylbutyrate and placebo cholecalciferol;   Drug: Placebo Sodium Phenylbutyrate plus placebo cholecalciferol
11 Completed Safety and Tolerability Study of Phenylbutyrate in Huntington's Disease (PHEND-HD)
Condition: Huntington's Disease
Intervention: Drug: sodium phenylbutyrate
12 Completed
Has Results
Study to Evaluate Sodium Phenylbutyrate in Pre-symptomatic Infants With Spinal Muscular Atrophy
Condition: Spinal Muscular Atrophy
Intervention: Drug: Sodium phenylbutyrate (NaPB)
13 No longer available Buphenyl Therapy for Byler's Disease
Condition: Byler Disease
Intervention: Drug: Buphenyl
14 Completed Safety Study of Oral Sodium Phenylbutyrate in Subjects With ALS (Amyotrophic Lateral Sclerosis)
Condition: Amyotrophic Lateral Sclerosis
Intervention: Drug: sodium phenylbutyrate
15 Completed
Has Results
Study of the Safety and Tolerability of HPN-100 Compared to Sodium Phenylbutyrate in Children With Urea Cycle Disorders
Condition: Urea Cycle Disorders
Interventions: Drug: HPN-100;   Drug: NaPBA
16 Completed Phenylbutyrate to Treat Children With Progressive or Recurrent Brain Tumors
Condition: Brain Tumor
Intervention: Drug: Phenylbutyrate
17 Terminated Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced Colorectal Cancer
Conditions: Mucinous Adenocarcinoma of the Colon;   Mucinous Adenocarcinoma of the Rectum;   Recurrent Colon Cancer;   Recurrent Rectal Cancer;   Signet Ring Adenocarcinoma of the Colon;   Signet Ring Adenocarcinoma of the Rectum;   Stage IVA Colon Cancer;   Stage IVA Rectal Cancer;   Stage IVB Colon Cancer;   Stage IVB Rectal Cancer
Interventions: Drug: fluorouracil;   Drug: sodium phenylbutyrate;   Drug: indomethacin;   Biological: recombinant interferon gamma
18 Terminated
Has Results
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Type I
Condition: Spinal Muscular Atrophy Type I
Intervention: Drug: sodium phenylbutyrate
19 Terminated
Has Results
Clinical Trial of Sodium Phenylbutyrate in Children With Spinal Muscular Atrophy Types II or III
Conditions: Spinal Muscular Atrophy Type II;   Spinal Muscular Atrophy Type III
Intervention: Drug: sodium phenylbutyrate
20 Completed Phenylbutyrate in Treating Patients With Refractory Solid Tumors or Lymphoma
Conditions: Lymphoma;   Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: chemotherapy;   Drug: oral sodium phenylbutyrate

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Study has passed its completion date and status has not been verified in more than two years.